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What is UniProt ?

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible ressource of protein sequence and functional information.

The UniProt Knowledgebase consists of two sections:

  • Swiss-Prot which contains high quality manually annotated and non-redundant protein sequences. This database brings together experimental results, computed features and scientific conclusions.
  • TrEMBL which contains protein sequences associated with computationally generated annotation and large-scale functional characterization that await full manual annotation.

More than 99% of the protein sequences provided by UniProtKB are derived from the translation of the coding sequences (CDS) which have been submitted to the public nucleic acid databases, the EMBL-Bank/GenBank/DDBJ databases. All these sequences, as well as the related data submitted by the authors, are automatically integrated into UniProtKB/TrEMBL.

More: http://www.uniprot.org/

Reference: UniProt Consortium. The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 2010 Jan;38(Database issue):D142-8