Label ID Type Frame Begin End Length Evidence Mutation Gene Synonyms Product Class ProductType Localization Roles ECnumber MicroCycRid MicroCycPid RheaRid AnnotatedRid CreationDate AmigeneStatus PubmedID Note BioProcess Matrix Annotator Atot Ctot Gtot Ttot GCtot ATtot A1 C1 G1 T1 GC1 AT1 A2 C2 G2 T2 GC2 AT2 A3 C3 G3 T3 GC3 AT3 CAI MW KD Tiny Small Aliphatic Aromatic Non_Polar Polar Charged Basic Acidic Pi OI NMV_0001 2190963 CDS -2 7 498 492 validated/Curated no putative acetyltransferase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-27 17:23:25 no 1 vladimir 0.20935 0.1789 0.308943 0.302846 0.487805 0.512195 0.182927 0.176829 0.384146 0.256098 0.560976 0.439024 0.292683 0.176829 0.207317 0.323171 0.384146 0.615854 0.152439 0.182927 0.335366 0.329268 0.518293 0.481707 0.52692 18750.79 -0.044785 0.251534 0.466258 0.239264 0.184049 0.607362 0.392638 0.282209 0.153374 0.128834 6.31945 9.668712 NMV_0002 2190964 CDS -2 502 897 396 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2015-11-15 18:58:59 no 1 vladimir 0.27193 0.2047 0.307018 0.216374 0.511696 0.488304 0.245614 0.210526 0.377193 0.166667 0.587719 0.412281 0.324561 0.219298 0.192982 0.263158 0.412281 0.587719 0.245614 0.184211 0.350877 0.219298 0.535088 0.464912 0.569871 12496.71 -0.304425 0.309735 0.460177 0.20354 0.079646 0.548673 0.451327 0.247788 0.132743 0.115044 8.248573 9.495575 NMV_0003 2190965 CDS -3 918 2312 1395 validated/Curated no gltX glutamate-tRNA ligase (glutamyl-tRNA synthetase; GluRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 2.3.1 : Amino acid-activation ; 6.1.1.17 GLURS-RXN PWY-5188$TRNA-CHARGING-PWY 2018-01-29 19:04:19 no Catalyses the attachment of glutamate to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.264516 0.3032 0.246595 0.185663 0.549821 0.450179 0.258065 0.2 0.384946 0.156989 0.584946 0.415054 0.341935 0.208602 0.167742 0.28172 0.376344 0.623656 0.193548 0.501075 0.187097 0.11828 0.688172 0.311828 0.789046 52441.095 -0.319828 0.25431 0.476293 0.219828 0.112069 0.553879 0.446121 0.31681 0.157328 0.159483 5.524879 9.728448 NMV_0004 2190966 CDS -1 2504 3160 657 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-27 17:27:37 no 1 vladimir 0.197869 0.2451 0.305936 0.251142 0.550989 0.449011 0.223744 0.219178 0.333333 0.223744 0.552511 0.447489 0.260274 0.205479 0.232877 0.30137 0.438356 0.561644 0.109589 0.310502 0.351598 0.22831 0.6621 0.3379 0.614449 24821.785 -0.111468 0.275229 0.490826 0.229358 0.146789 0.605505 0.394495 0.229358 0.155963 0.073394 10.07238 9.958716 NMV_0005 2190967 CDS -2 3157 3510 354 validated/Curated no putative arsenate reductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.6.2 : Detoxification (xenobiotic metabolism) ; 1.20.4.1 RXN-7002$RXN-982 PWY-4621 2017-12-20 12:14:58 no 7721697 Catalyses the following reaction: arsenate + glutaredoxin <=> arsenite + glutaredoxin disulfide. 1 vladimir 0.231638 0.2345 0.288136 0.245763 0.522599 0.477401 0.237288 0.186441 0.372881 0.20339 0.559322 0.440678 0.313559 0.228814 0.144068 0.313559 0.372881 0.627119 0.144068 0.288136 0.347458 0.220339 0.635593 0.364407 0.700365 12897.49 -0.131624 0.230769 0.470085 0.273504 0.051282 0.581197 0.418803 0.316239 0.153846 0.162393 5.395424 9.230769 NMV_0006 2190968 CDS +1 3634 4116 483 validated/Curated no putative periplasmic thioredoxin 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 2017-12-20 12:16:44 no Thioredoxins are small proteins, which participate in various redox reactions via the reversible oxidation of an active center disulfide bond. They exist in either a reduced form or an oxidised form where the two cysteine residues are linked by an intramolecular disulfide bond. 2 vladimir 0.279503 0.3085 0.233954 0.178054 0.542443 0.457557 0.31677 0.186335 0.329193 0.167702 0.515528 0.484472 0.291925 0.285714 0.186335 0.236025 0.47205 0.52795 0.229814 0.453416 0.186335 0.130435 0.639752 0.360248 0.646171 17521.495 -0.196875 0.3625 0.5625 0.18125 0.10625 0.56875 0.43125 0.20625 0.1375 0.06875 9.514503 9.4 NMV_0007 2190969 CDS +2 4310 4960 651 validated/Curated no ftsE cell division ATP-binding protein FtsE 2a : Function from experimental evidences in other organisms t : transporter 2 : Cytoplasmic 5.1 : Cell division ; 2020-02-19 11:47:50 no FtsE is an ABC transporter ATP-binding protein. This protein and its permease partner FtsX localise to the cell division site and are involved in cell division. 2 vladimir 0.265745 0.3287 0.219662 0.185868 0.548387 0.451613 0.271889 0.271889 0.331797 0.124424 0.603687 0.396313 0.308756 0.198157 0.179724 0.313364 0.37788 0.62212 0.21659 0.516129 0.147465 0.119816 0.663594 0.336406 0.68506 24012.825 -0.189815 0.268519 0.449074 0.25 0.101852 0.546296 0.453704 0.277778 0.171296 0.106481 9.457253 9.12963 NMV_0008 2190970 CDS +1 4957 5874 918 validated/Curated no ftsX cell division protein FtsX 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 5.1 : Cell division ; 2020-02-19 11:48:34 no FtsX is an ABC transporter permease protein. This protein and its ATP-binding protein partner FtsE localise to the cell division site and are involved in cell division. 2 vladimir 0.233115 0.3159 0.228758 0.222222 0.544662 0.455338 0.281046 0.271242 0.277778 0.169935 0.54902 0.45098 0.24183 0.222222 0.156863 0.379085 0.379085 0.620915 0.176471 0.454248 0.251634 0.117647 0.705882 0.294118 0.654744 34209.98 0.342951 0.268852 0.442623 0.291803 0.108197 0.609836 0.390164 0.180328 0.098361 0.081967 7.993828 8.62623 NMV_0010 2190972 CDS +1 5965 6213 249 validated/Curated no putative BolA-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2020-02-19 11:49:33 no In E. coli, over-expression of the morpho-protein BolA causes round morphology, and may be involved in switching the cell between elongation and septation systems during cell division. 2 vladimir 0.305221 0.2691 0.24498 0.180723 0.514056 0.485944 0.204819 0.240964 0.433735 0.120482 0.674699 0.325301 0.349398 0.240964 0.13253 0.277108 0.373494 0.626506 0.361446 0.325301 0.168675 0.144578 0.493976 0.506024 0.715169 8978.895 -0.120732 0.317073 0.439024 0.219512 0.109756 0.536585 0.463415 0.317073 0.170732 0.146341 5.921043 9.158537 NMV_0011 2190973 CDS -1 6278 7456 1179 validated/Curated no pgk phosphoglycerate kinase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 2.7.2.3 PHOSGLYPHOS-RXN ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-30 12:22:52 no Catalyses the following reaction: ATP + 3-phospho-D-glycerate <=> ADP + 3-phospho-D-glyceroyl phosphate. 2 vladimir 0.228159 0.2926 0.291773 0.187447 0.584394 0.415606 0.231552 0.142494 0.486005 0.139949 0.628499 0.371501 0.287532 0.272265 0.142494 0.29771 0.414758 0.585242 0.165394 0.463104 0.246819 0.124682 0.709924 0.290076 0.792041 40599.915 0.170153 0.354592 0.579082 0.239796 0.061224 0.617347 0.382653 0.244898 0.117347 0.127551 5.25486 8.872449 NMV_0012 2190974 CDS -2 7537 8790 1254 validated/Curated no murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 2.5.1.7 UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2017-12-20 12:26:04 no Catalyses the following reaction, which is the first committed step of bacterial cell wall biosynthesis: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. 1 vladimir 0.220893 0.2464 0.339713 0.192982 0.586124 0.413876 0.270335 0.172249 0.442584 0.114833 0.614833 0.385167 0.253589 0.236842 0.19378 0.315789 0.430622 0.569378 0.138756 0.330144 0.382775 0.148325 0.712919 0.287081 0.642193 43891.9 0.17458 0.345324 0.568345 0.261391 0.047962 0.59952 0.40048 0.227818 0.11271 0.115108 5.543999 9.817746 NMV_tRNA_59 2194874 tRNA -1 9009 9084 76 validated/Curated no Lys tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:45:54 no tRNA Lys anticodon TTT. vladimir NMV_0013 2190975 CDS -3 9153 10127 975 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms m : membrane component 5 : Inner membrane protein 2020-04-23 17:55:41 no 12107143, 15096624 Integral membrane protein belonging to a family named after TerC, which has been implicated in resistance to tellurium. This entry represents a subset of TerC proteins including the putative membrane-bound redox modulator Alx, which are mostly encoded by genes preceded by a structured RNA element possibly functioning as a riboswitch. 1 vladimir 0.205128 0.2236 0.28 0.291282 0.50359 0.49641 0.227692 0.147692 0.375385 0.249231 0.523077 0.476923 0.227692 0.193846 0.135385 0.443077 0.329231 0.670769 0.16 0.329231 0.329231 0.181538 0.658462 0.341538 0.724575 35754.115 0.835802 0.268519 0.472222 0.314815 0.166667 0.709877 0.290123 0.166667 0.092593 0.074074 7.183556 8.41358 NMV_0014 2190976 CDS -1 10160 10609 450 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2007-10-22 17:13:20 no 1 vladimir 0.173333 0.2556 0.288889 0.282222 0.544444 0.455556 0.24 0.173333 0.353333 0.233333 0.526667 0.473333 0.16 0.233333 0.153333 0.453333 0.386667 0.613333 0.12 0.36 0.36 0.16 0.72 0.28 0.654563 16511.31 1.106711 0.315436 0.47651 0.322148 0.174497 0.718121 0.281879 0.154362 0.120805 0.033557 9.79702 8.966443 NMV_0015 2190977 CDS -3 10650 11921 1272 validated/Curated no kdtA waaA 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.4.99.12, 2.4.99.13 KDOTRANS-RXN$KDOTRANS2-RXN KDO-NAGLIPASYN-PWY$KDOSYN-PWY 2020-02-19 15:18:55 no 11948150 Catalyses a step in lipooligosaccharide biosynthesis by transferring 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to lipid A. 1 vladimir 0.197327 0.2618 0.331761 0.209119 0.593553 0.406447 0.17217 0.266509 0.375 0.186321 0.641509 0.358491 0.259434 0.252358 0.231132 0.257075 0.483491 0.516509 0.160377 0.266509 0.389151 0.183962 0.65566 0.34434 0.57447 47170.37 -0.240189 0.316785 0.498818 0.193853 0.113475 0.591017 0.408983 0.250591 0.146572 0.104019 9.113213 10.219858 NMV_0016 2190978 CDS -1 11984 13432 1449 validated/Curated no gnd 6-phosphogluconate dehydrogenase, decarboxylating 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.2 : Pentose phosphate shunt, oxidative branch ; 1.1.1.44 6PGLUCONDEHYDROG-RXN$RXN-3341 OXIDATIVEPENT-PWY 2018-01-29 18:00:48 no Catalyses the following reaction: 6-phospho-D-gluconate + NADP(+) <=> D-ribulose 5-phosphate + CO(2) + NADPH. 1 vladimir 0.240856 0.2429 0.299517 0.216701 0.542443 0.457557 0.256729 0.165631 0.391304 0.186335 0.556936 0.443064 0.308489 0.207039 0.202899 0.281574 0.409938 0.590062 0.15735 0.356108 0.304348 0.182195 0.660455 0.339545 0.674541 53025.355 -0.150207 0.309129 0.504149 0.213693 0.109959 0.593361 0.406639 0.246888 0.114108 0.13278 5.036537 9.740664 NMV_0017 2190979 CDS -1 14960 15883 924 validated/Curated no lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 3.5.1.108 UDPACYLGLCNACDEACETYL-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2017-12-20 12:30:59 no Is involved in lipid A biosynthesis. 1 vladimir 0.237013 0.2771 0.258658 0.227273 0.535714 0.464286 0.269481 0.201299 0.366883 0.162338 0.568182 0.431818 0.311688 0.214286 0.155844 0.318182 0.37013 0.62987 0.12987 0.415584 0.253247 0.201299 0.668831 0.331169 0.716294 33966.34 -0.09316 0.270358 0.501629 0.247557 0.117264 0.560261 0.439739 0.273616 0.130293 0.143322 5.1269 9.247557 NMV_0019 2190981 CDS -3 16989 17495 507 validated/Curated no pilE major pilin PilE 1a : Function from experimental evidences in the studied strain s : structure 3 : Fimbrial 6.5 : Pilus ; 2020-04-25 13:45:10 no 8332064 Major pilus subunit. Highly-adhesive variant known as SB. 2 vladimir 0.278107 0.3136 0.220907 0.187377 0.534517 0.465483 0.325444 0.159763 0.366864 0.147929 0.526627 0.473373 0.307692 0.307692 0.147929 0.236686 0.455621 0.544379 0.201183 0.473373 0.147929 0.177515 0.621302 0.378698 0.739884 17822.375 -0.133333 0.392857 0.607143 0.208333 0.071429 0.52381 0.47619 0.190476 0.107143 0.083333 8.51432 8.946429 NMNmiscRNA0159 54919392 misc_RNA +1 16990 17776 787 validated/Curated no AS RNA 1a : Function from experimental evidences in the studied strain 2018-01-29 12:18:20 25755192, 28334889 PilE antisense RNA influencing pilin antigenic variation in Neisseria meningitidis. vladimir NMNmiscRNA0158 54919391 misc_RNA +1 17872 18035 164 validated/Curated no pilE G4-associated sRNA 1c : Function from experimental evidences in the studied genus 2018-01-29 12:06:41 23349628, 28334889 This ncRNA is required for pilin antigenic variation in Neisseria gonorrhoeae. vladimir NMV_0022 2190984 CDS -2 19549 19914 366 validated/Curated partial pilS1 pilS1 cassette 1c : Function from experimental evidences in the studied genus s : structure 1 : Unknown 6.5 : Pilus ; 2017-12-20 12:32:25 no 2866848, 2897186 Non-expressed (silent) variable pilin minicassette, which is flanked by strictly conserved sequences and can be transferred to the expression locus by gene conversion. 2 vladimir 0.309524 0.2976 0.22381 0.169048 0.521429 0.478571 0.321429 0.121429 0.392857 0.164286 0.514286 0.485714 0.357143 0.321429 0.135714 0.185714 0.457143 0.542857 0.25 0.45 0.142857 0.157143 0.592857 0.407143 0.723701 14830.95 -0.522302 0.381295 0.647482 0.165468 0.071942 0.47482 0.52518 0.266187 0.151079 0.115108 8.729439 8.964029 NMV_0023 2190985 CDS -3 20163 20519 357 validated/Curated partial pilS2 pilS2 cassette 1c : Function from experimental evidences in the studied genus s : structure 1 : Unknown 6.5 : Pilus ; 2017-12-20 12:33:33 no 2866848, 2897186 Non-expressed (silent) variable pilin minicassette, which is flanked by strictly conserved sequences and can be transferred to the expression locus by gene conversion. 2 vladimir 0.306173 0.2963 0.224691 0.17284 0.520988 0.479012 0.318519 0.133333 0.377778 0.17037 0.511111 0.488889 0.37037 0.281481 0.155556 0.192593 0.437037 0.562963 0.22963 0.474074 0.140741 0.155556 0.614815 0.385185 0.74726 14498.455 -0.602985 0.358209 0.634328 0.171642 0.08209 0.462687 0.537313 0.268657 0.134328 0.134328 5.646324 9.149254 NMV_0024 2190986 CDS -1 20813 21160 348 validated/Curated partial pilS3 pilS3 cassette 1c : Function from experimental evidences in the studied genus s : structure 1 : Unknown 6.5 : Pilus ; 2017-12-20 12:33:44 no 2866848, 2897186 Non-expressed (silent) variable pilin minicassette, which is flanked by strictly conserved sequences and can be transferred to the expression locus by gene conversion. 2 vladimir 0.305709 0.3112 0.198895 0.184162 0.510129 0.489871 0.342541 0.209945 0.276243 0.171271 0.486188 0.513812 0.325967 0.298343 0.171271 0.20442 0.469613 0.530387 0.248619 0.425414 0.149171 0.176796 0.574586 0.425414 0.685632 19821.575 -0.634444 0.361111 0.577778 0.166667 0.094444 0.433333 0.566667 0.25 0.183333 0.066667 10.05262 8.994444 NMV_0024.1 2198827 CDS -3 21210 21476 267 validated/Curated partial pilS4 pilS4 cassette 1c : Function from experimental evidences in the studied genus s : structure 1 : Unknown 6.5 : Pilus ; 2017-12-20 12:33:57 2866848, 2897186 Non-expressed (silent) variable pilin minicassette, which is flanked by strictly conserved sequences and can be transferred to the expression locus by gene conversion. vladimir NMV_0025 2190987 CDS -3 21723 21932 210 validated/Curated partial pilS5 pilS5 cassette 1c : Function from experimental evidences in the studied genus s : structure 1 : Unknown 6.5 : Pilus ; 2017-12-20 12:34:09 no 2866848, 2897186 Non-expressed (silent) variable pilin minicassette, which is flanked by strictly conserved sequences and can be transferred to the expression locus by gene conversion. 2 vladimir 0.308743 0.3005 0.226776 0.163934 0.527322 0.472678 0.303279 0.221311 0.303279 0.172131 0.52459 0.47541 0.344262 0.254098 0.204918 0.196721 0.459016 0.540984 0.278689 0.42623 0.172131 0.122951 0.598361 0.401639 0.658957 13417.67 -0.807438 0.338843 0.53719 0.157025 0.07438 0.429752 0.570248 0.330579 0.214876 0.115702 9.751091 8.801653 NMV_0026 2190988 CDS -2 21961 22290 330 validated/Curated no fkbP fbp FK506-binding protein (peptidyl-prolyl cis-trans isomerase; PPIase; rotamase) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2020-02-19 13:11:06 no 1371354 Accelerates protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. 2 vladimir 0.272727 0.2576 0.287879 0.181818 0.545455 0.454545 0.263636 0.190909 0.418182 0.127273 0.609091 0.390909 0.318182 0.163636 0.227273 0.290909 0.390909 0.609091 0.236364 0.418182 0.218182 0.127273 0.636364 0.363636 0.728193 11833.06 -0.209174 0.311927 0.458716 0.229358 0.110092 0.587156 0.412844 0.284404 0.137615 0.146789 5.328453 9.009174 NMV_0027 2190989 CDS -3 22368 22586 219 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-27 17:31:28 no 1 vladimir 0.287671 0.2785 0.200913 0.232877 0.479452 0.520548 0.328767 0.246575 0.246575 0.178082 0.493151 0.506849 0.273973 0.232877 0.150685 0.342466 0.383562 0.616438 0.260274 0.356164 0.205479 0.178082 0.561644 0.438356 0.515252 8122.135 0.306944 0.319444 0.472222 0.25 0.180556 0.569444 0.430556 0.152778 0.111111 0.041667 8.93206 8.527778 NMV_0028 2190990 CDS +1 22708 23661 954 validated/Curated no putative glycerate dehydrogenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.1.11 : Serine ; 1.1.1.29 GLYCERATE-DEHYDROGENASE-RXN 2018-01-27 17:34:51 no Belongs to the NAD-dependent D-isomer specific 2-hydroxyacid dehydrogenase family. Is likely to catalyse the following reaction: D-glycerate + NAD(+) <=> hydroxypyruvate + NADH. 1 vladimir 0.218029 0.2306 0.319706 0.231656 0.550314 0.449686 0.235849 0.204403 0.424528 0.13522 0.628931 0.371069 0.283019 0.248428 0.166667 0.301887 0.415094 0.584906 0.13522 0.238994 0.367925 0.257862 0.606918 0.393082 0.573595 33938.48 0.103155 0.312303 0.561514 0.239748 0.097792 0.624606 0.375394 0.214511 0.116719 0.097792 6.214668 9.984227 NMV_0029 2190991 CDS -1 23735 25792 2058 validated/Curated no metG methionine-tRNA ligase (methionyl-tRNA synthetase; MetRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.10 METHIONINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2017-12-20 12:38:40 no Catalyses the attachment of methionine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.275996 0.3129 0.227405 0.183673 0.54033 0.45967 0.262391 0.198251 0.360058 0.1793 0.558309 0.441691 0.358601 0.223032 0.154519 0.263848 0.377551 0.622449 0.206997 0.517493 0.167638 0.107872 0.685131 0.314869 0.78085 76885.35 -0.332847 0.284672 0.483212 0.183942 0.134307 0.551825 0.448175 0.274453 0.137226 0.137226 5.557564 9.524088 NMV_0030 2190992 CDS -3 25908 27746 1839 validated/Curated no glmS glutamine-fructose-6-phosphate aminotransferase [isomerizing] (hexosephosphate aminotransferase; D-fructose-6- phosphate amidotransferase; GFAT; L-glutamine-D-fructose-6-phosphate amidotransferase; glucosamine-6-phosphate synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.2 : Peptidoglycan (murein) ; 6.3 : Surface antigens (ECA, O antigen of LPS) ; 2.6.1.16 L-GLN-FRUCT-6-P-AMINOTRANS-RXN OANTIGEN-PWY$UDPNAGSYN-PWY 2020-04-21 13:50:37 no Catalyses the following reaction, which is the first and rate-limiting of the hexosamine biosynthetic pathway: L-glutamine + D-fructose 6-phosphate <=> L-glutamate + D-glucosamine 6-phosphate. The final product of the hexosamine pathway, UDP-N-acetyl glucosamine, is an active precursor of numerous macromolecules containing amino sugars. 2 vladimir 0.235454 0.3100 0.26808 0.186514 0.578032 0.421968 0.236542 0.223491 0.406199 0.133768 0.62969 0.37031 0.300163 0.231648 0.177814 0.290375 0.409462 0.590538 0.169657 0.474715 0.220228 0.1354 0.694943 0.305057 0.707643 66609.405 -0.071895 0.312092 0.511438 0.245098 0.102941 0.565359 0.434641 0.269608 0.145425 0.124183 6.217125 9.326797 NMV_0031 2190993 CDS +2 28028 28546 519 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2007-10-22 17:18:33 no 1 vladimir 0.321773 0.1985 0.283237 0.196532 0.481696 0.518304 0.294798 0.156069 0.369942 0.179191 0.526012 0.473988 0.433526 0.179191 0.138728 0.248555 0.317919 0.682081 0.236994 0.260116 0.34104 0.16185 0.601156 0.398844 0.573379 19267.295 -0.57907 0.267442 0.424419 0.19186 0.087209 0.511628 0.488372 0.313953 0.168605 0.145349 8.331459 9.273256 NMV_0032 2190994 CDS -1 28964 30433 1470 validated/Curated no mltA membrane-bound lytic murein transglycosylase A (murein hydrolase A; GNA33) 1b : Function from experimental evidences in the studied species e : enzyme 8 : Outer membrane-associated 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 2018-02-01 17:49:21 no 12153569, 15039310 Degrades murein glycan strands and insoluble high-molecular weight murein sacculi. Plays a role in recycling of muropeptides during cell elongation and/or cell division. 2 vladimir 0.232278 0.3273 0.259427 0.180995 0.586727 0.413273 0.253394 0.255656 0.341629 0.149321 0.597285 0.402715 0.282805 0.257919 0.219457 0.239819 0.477376 0.522624 0.160633 0.468326 0.217195 0.153846 0.68552 0.31448 0.635374 48045.84 -0.337188 0.335601 0.535147 0.176871 0.124717 0.594104 0.405896 0.208617 0.133787 0.07483 9.63221 9.585034 NMV_0033 2190995 CDS +2 30500 31339 840 validated/Curated no efeU ferrous iron permease EfeU 2a : Function from experimental evidences in other organisms t : transporter 11 : Membrane 2017-12-20 12:43:02 no 17627767, 16987175 1 vladimir 0.166667 0.2274 0.325 0.280952 0.552381 0.447619 0.203571 0.210714 0.375 0.210714 0.585714 0.414286 0.2 0.210714 0.203571 0.385714 0.414286 0.585714 0.096429 0.260714 0.396429 0.246429 0.657143 0.342857 0.608852 30231.62 0.63405 0.322581 0.462366 0.290323 0.121864 0.698925 0.301075 0.157706 0.096774 0.060932 9.250786 8.727599 NMV_0034 2190996 CDS +1 31336 32502 1167 validated/Curated no efeO ferrous iron uptake system component EfeO 2a : Function from experimental evidences in other organisms t : transporter 11 : Membrane 2017-10-25 23:05:48 no 17627767, 16987175 1 vladimir 0.278492 0.2639 0.275064 0.182519 0.538989 0.461011 0.272494 0.164524 0.429306 0.133676 0.59383 0.40617 0.357326 0.228792 0.141388 0.272494 0.37018 0.62982 0.205656 0.398458 0.254499 0.141388 0.652956 0.347044 0.723007 42249.235 -0.299742 0.296392 0.515464 0.219072 0.069588 0.528351 0.471649 0.304124 0.131443 0.17268 4.804756 9.139175 NMV_0035 2190997 CDS +3 32766 34043 1278 validated/Curated no efeB deferrochelatase/peroxidase EfeB 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.11.1.- RXN0-6258 2018-01-23 13:32:23 no 17627767, 16987175 Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. 2 vladimir 0.242567 0.3185 0.271518 0.167449 0.589984 0.410016 0.239437 0.248826 0.36385 0.147887 0.612676 0.387324 0.312207 0.220657 0.2277 0.239437 0.448357 0.551643 0.176056 0.485915 0.223005 0.115023 0.70892 0.29108 0.671601 46532.58 -0.449647 0.322353 0.524706 0.171765 0.112941 0.550588 0.449412 0.247059 0.129412 0.117647 6.446983 9.322353 NMV_0036 2190998 CDS -1 34115 34444 330 validated/Curated no putative PhnA-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2017-12-20 12:45:31 no This protein family includes an uncharacterised member designated PhnA in E. coli, part of a large operon associated with alkylphosphonate uptake and carbon-phosphorus bond cleavage. 2 vladimir 0.315152 0.2909 0.236364 0.157576 0.527273 0.472727 0.290909 0.172727 0.372727 0.163636 0.545455 0.454545 0.372727 0.218182 0.190909 0.218182 0.409091 0.590909 0.281818 0.481818 0.145455 0.090909 0.627273 0.372727 0.711635 11759.81 -0.415596 0.33945 0.541284 0.183486 0.06422 0.522936 0.477064 0.266055 0.12844 0.137615 5.308052 9.431193 NMV_0037 2190999 CDS -1 34520 35890 1371 validated/Curated no glmU bifunctional GlmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase) and glucosamine-1-phosphate N-acetyltransferase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.2 : Peptidoglycan (murein) ; 6.3 : Surface antigens (ECA, O antigen of LPS) ; 2.7.7.23, 2.3.1.157 2.3.1.157-RXN$NAG1P-URIDYLTRANS-RXN OANTIGEN-PWY$UDPNAGSYN-PWY 2018-01-30 10:50:27 no Catalyses the last two sequential reactions in the de novo biosynthetic pathway of UDP-GlcNAc: acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate and UTP + N-acetyl-alpha-D-glucosamine 1-phosphate <=> diphosphate + UDP-N-acetyl-D-glucosamine. 2 vladimir 0.272064 0.3282 0.238512 0.161196 0.56674 0.43326 0.286652 0.212254 0.415755 0.085339 0.628009 0.371991 0.323851 0.212254 0.177243 0.286652 0.389497 0.610503 0.205689 0.560175 0.122538 0.111597 0.682713 0.317287 0.757483 48810.625 -0.127632 0.302632 0.552632 0.265351 0.061404 0.552632 0.447368 0.258772 0.138158 0.120614 6.349251 9.399123 NMV_0038 2191000 CDS -1 35945 36922 978 validated/Curated no putative HAD-superfamily hydrolase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2020-02-19 12:14:50 no Belongs to the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. In some strains of N. meningitidis (Z2491 and MC58) and in N. gonorrhoeae, the C-terminus is a separate protein. 2 vladimir 0.258691 0.3221 0.230061 0.189162 0.552147 0.447853 0.242331 0.291411 0.303681 0.162577 0.595092 0.404908 0.349693 0.239264 0.165644 0.245399 0.404908 0.595092 0.184049 0.435583 0.220859 0.159509 0.656442 0.343558 0.678094 36987.47 -0.550769 0.267692 0.495385 0.178462 0.132308 0.526154 0.473846 0.258462 0.150769 0.107692 8.548927 9.993846 NMV_0039 2191001 CDS +3 36981 37982 1002 validated/Curated no thiB tbpA thiamine-binding periplasmic protein 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 9 : Periplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2020-02-19 13:13:31 no The thiamine ABC transporter is believed to be involved in the specific translocation of thiamine and its phosphoesters across the inner-membrane. The protein belongs to the larger ABC transport system, which consists of at least three components: the inner-membrane permease; the thiamine-binding protein and an ATP-binding subunit. 2 vladimir 0.219561 0.2794 0.316367 0.184631 0.595808 0.404192 0.230539 0.233533 0.365269 0.170659 0.598802 0.401198 0.290419 0.269461 0.173653 0.266467 0.443114 0.556886 0.137725 0.335329 0.41018 0.116766 0.745509 0.254491 0.65808 36457.56 -0.15976 0.303303 0.522523 0.213213 0.108108 0.60961 0.39039 0.204204 0.129129 0.075075 9.77993 9.183183 NMV_0040 2191002 CDS +3 38076 38924 849 validated/Curated no putative small-conductance mechanosensitive channel protein (MscS) 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2017-12-20 12:51:03 no Mechanosensitive channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. 1 vladimir 0.226148 0.2556 0.28033 0.237927 0.535925 0.464075 0.265018 0.166078 0.381625 0.187279 0.547703 0.452297 0.254417 0.219081 0.162544 0.363958 0.381625 0.618375 0.159011 0.381625 0.29682 0.162544 0.678445 0.321555 0.679777 30794.625 0.438652 0.29078 0.51773 0.304965 0.088652 0.620567 0.379433 0.195035 0.102837 0.092199 6.425941 9.131206 NMV_0041 2191003 CDS +1 38950 39435 486 validated/Curated no pncC nicotinamide-nucleotide amidohydrolase PncC 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.5.1.42 NMNAMIDOHYDRO-RXN PYRIDNUCSAL-PWY 2017-12-20 15:03:40 no 21953451 Catalyses the following reaction: beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinate D-ribonucleotide + NH3. 1 vladimir 0.209877 0.2901 0.320988 0.179012 0.611111 0.388889 0.216049 0.179012 0.450617 0.154321 0.62963 0.37037 0.234568 0.246914 0.271605 0.246914 0.518519 0.481481 0.179012 0.444444 0.240741 0.135802 0.685185 0.314815 0.703356 16863.29 -0.043478 0.42236 0.596273 0.180124 0.093168 0.590062 0.409938 0.21118 0.111801 0.099379 6.904137 9.621118 NMV_0042 2191004 CDS -3 39537 41105 1569 validated/Curated no msrAB pilB peptide methionine sulfoxide reductase MsrA/MsrB [includes: thioredoxin, peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase; peptide Met(O) reductase) and peptide methionine sulfoxide reductase MsrB] 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.8.4.11 RXN-8668$RXN-8669 2018-03-22 16:55:08 no 11812798, 12096194, 15668226 Peptide methionine sulfoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulfoxide, Met(O), to methionine. The Neisserial enzyme possesses three domains: MsrA and MsrB domains that reduce different epimeric forms of methionine sulfoxide, but also a specific thioredoxin domain. 2 vladimir 0.269598 0.3059 0.240918 0.183556 0.546845 0.453155 0.271511 0.195029 0.338432 0.195029 0.533461 0.466539 0.367113 0.231358 0.17782 0.223709 0.409178 0.590822 0.170172 0.491396 0.206501 0.131931 0.697897 0.302103 0.770454 58013.045 -0.511303 0.308429 0.532567 0.176245 0.136015 0.52682 0.47318 0.268199 0.14751 0.12069 7.294319 9.072797 NMV_0043 2191005 CDS +1 41251 42516 1266 validated/Curated no ftsY pilA signal recognition particle receptor FtsY 1c : Function from experimental evidences in the studied genus rc : receptor 6 : Inner membrane-associated 5.1 : Cell division ; 2020-02-19 12:19:37 no 12533455, 9922234 Belongs to the GTP-binding signal recognition particle (SRP) family. SRP is an oligomeric complex, consisting of a 7S RNA and six protein subunits, which mediates targeting and insertion of the signal sequence of exported proteins into the membrane of the endoplasmic reticulum. One of these subunits, the 54 kD protein (SRP54), is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. 1 vladimir 0.266193 0.2725 0.28594 0.175355 0.558452 0.441548 0.232227 0.189573 0.476303 0.101896 0.665877 0.334123 0.329384 0.248815 0.13981 0.281991 0.388626 0.611374 0.236967 0.379147 0.241706 0.14218 0.620853 0.379147 0.717158 45167.64 -0.153444 0.313539 0.515439 0.235154 0.049881 0.548694 0.451306 0.289786 0.125891 0.163895 4.842461 9.330166 NMV_0044 2191006 CDS +1 42766 43050 285 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2017-12-20 15:08:13 no Similar to the N-terminus of the excinuclease ABC C subunit. 3 vladimir 0.301754 0.1509 0.242105 0.305263 0.392982 0.607018 0.315789 0.2 0.242105 0.242105 0.442105 0.557895 0.368421 0.157895 0.168421 0.305263 0.326316 0.673684 0.221053 0.094737 0.315789 0.368421 0.410526 0.589474 0.578156 11353.615 -0.373404 0.191489 0.361702 0.255319 0.159574 0.510638 0.489362 0.244681 0.138298 0.106383 7.034447 9.734043 NMV_0045 2191007 CDS +3 44571 47705 3135 validated/Curated no pilC2 type IV pilus-associated protein PilC2 1a : Function from experimental evidences in the studied strain f : factor 8 : Outer membrane-associated 6.5 : Pilus ; 2020-04-25 13:57:23 no 15103324, 1671354, 7909606, 9844000 Outer membrane protein, required for pilus biogenesis. In N. meningitidis, there are two pilC alleles. PilC1, but not PilC2, has an additional function since it also promotes adhesion to host cells. 1 vladimir 0.286762 0.2507 0.254226 0.208293 0.504944 0.495056 0.34067 0.16555 0.333014 0.160766 0.498565 0.501435 0.35311 0.208612 0.204785 0.233493 0.413397 0.586603 0.166507 0.37799 0.22488 0.230622 0.602871 0.397129 0.644764 114226.155 -0.613793 0.318008 0.577586 0.18295 0.100575 0.487548 0.512452 0.25 0.145594 0.104406 9.31028 9.070881 NMV_0046 2191008 CDS -2 49966 52116 2151 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2007-10-22 17:45:06 no 2 vladimir 0.227801 0.4012 0.199442 0.171548 0.600651 0.399349 0.269177 0.295676 0.292887 0.142259 0.588563 0.411437 0.25802 0.25802 0.1841 0.299861 0.44212 0.55788 0.156206 0.64993 0.121339 0.072524 0.771269 0.228731 0.665212 79940.095 0.023184 0.326816 0.481844 0.234637 0.127095 0.565642 0.434358 0.205307 0.121508 0.083799 8.799934 9.25419 NMV_0047 2191009 CDS -2 52402 53628 1227 validated/Curated no pilU PilT-like protein PilU 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-25 14:02:09 no 12065533 Cytosolic ATPase that belongs to the PilT subfamily of proteins. Not required for pilus biogenesis, but modulates pilus-mediated functions. 2 vladimir 0.280359 0.3366 0.221679 0.161369 0.558272 0.441728 0.320293 0.278729 0.281174 0.119804 0.559902 0.440098 0.330073 0.224939 0.156479 0.288509 0.381418 0.618582 0.190709 0.506112 0.227384 0.075795 0.733496 0.266504 0.661685 45672.535 -0.308088 0.27451 0.458333 0.235294 0.080882 0.502451 0.497549 0.245098 0.134804 0.110294 6.503487 9.441176 NMV_0048 2191010 CDS -2 53791 54834 1044 validated/Curated no pilT type IV pilus retraction ATPase PilT 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-25 14:06:15 no 10993081, 17355871, 9701824 Cytosolic ATPase that powers pilus retraction. Not required for pilus biogenesis. 2 vladimir 0.255747 0.3238 0.241379 0.179119 0.565134 0.434866 0.298851 0.258621 0.321839 0.12069 0.58046 0.41954 0.281609 0.25 0.155172 0.313218 0.405172 0.594828 0.186782 0.462644 0.247126 0.103448 0.70977 0.29023 0.701225 38048.02 -0.154755 0.29683 0.504323 0.239193 0.072046 0.510086 0.489914 0.233429 0.129683 0.103746 6.646507 9.305476 NMV_0049 2191011 CDS +3 54954 55640 687 validated/Curated no pyridoxal phosphate homeostasis protein 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-03-22 16:59:51 no 24097949, 26872910 1 vladimir 0.222707 0.2402 0.323144 0.213974 0.563319 0.436681 0.244541 0.19214 0.419214 0.144105 0.611354 0.388646 0.28821 0.222707 0.19214 0.296943 0.414847 0.585153 0.135371 0.305677 0.358079 0.200873 0.663755 0.336245 0.621281 24854.655 -0.032456 0.307018 0.530702 0.245614 0.078947 0.570175 0.429825 0.263158 0.144737 0.118421 7.161125 9.72807 NMV_0050 2191012 CDS +2 55640 56047 408 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2007-10-22 17:46:17 no 1 vladimir 0.237745 0.2083 0.303922 0.25 0.512255 0.487745 0.213235 0.169118 0.323529 0.294118 0.492647 0.507353 0.308824 0.227941 0.25 0.213235 0.477941 0.522059 0.191176 0.227941 0.338235 0.242647 0.566176 0.433824 0.54811 15445.03 -0.515556 0.318519 0.459259 0.155556 0.125926 0.555556 0.444444 0.281481 0.148148 0.133333 8.24366 9.903704 NMV_0051 2191013 CDS +2 56096 56887 792 validated/Curated no proC pyrroline-5-carboxylate reductase (P5CR; P5C reductase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.4 : Proline ; 1.5.1.2 PYRROLINECARBREDUCT-RXN PROSYN-PWY 2017-12-20 15:11:21 no Catalyses the following reaction, which is the terminal step in the biosynthesis of proline from glutamate: L-proline + NAD(P)(+) <=> 1-pyrroline-5-carboxylate + NAD(P)H. 1 vladimir 0.252525 0.2311 0.29798 0.218434 0.52904 0.47096 0.238636 0.193182 0.431818 0.136364 0.625 0.375 0.287879 0.223485 0.212121 0.276515 0.435606 0.564394 0.231061 0.276515 0.25 0.242424 0.526515 0.473485 0.580162 28450.31 -0.187072 0.334601 0.51711 0.21673 0.072243 0.562738 0.437262 0.26616 0.140684 0.125475 6.60923 10.114068 NMV_0052 2191014 CDS +2 57035 57451 417 validated/Curated no dksA RNA polymerase-binding transcription factor DksA 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2017-12-20 15:11:57 no DksA is a critical component of the rRNA transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP. DksA suppresses the temperature-sensitive growth and filamentation of a dnaK deletion mutant of E. coli. In P. aeruginosa, DksA is also involved in the post-transcriptional control of extracellular virulence factor production. 1 vladimir 0.302158 0.2398 0.258993 0.199041 0.498801 0.501199 0.23741 0.258993 0.366906 0.136691 0.625899 0.374101 0.395683 0.223022 0.158273 0.223022 0.381295 0.618705 0.273381 0.23741 0.251799 0.23741 0.489209 0.510791 0.538961 15937.185 -0.915217 0.246377 0.42029 0.166667 0.07971 0.434783 0.565217 0.376812 0.15942 0.217391 4.742378 10.304348 NMNmiscRNA0077 52714412 misc_RNA -1 57431 57691 261 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-28 20:38:46 28334889 Function unknown but has three paralogs. vladimir NMV_16S_2 2194877 rRNA +1 57908 59452 1545 validated/Curated no ribosomal RNA 16S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:03:18 vladimir NMV_tRNA_1 2194816 tRNA +1 59550 59626 77 validated/Curated no Ile tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:46:13 no tRNA Ile anticodon GAT. vladimir NMV_tRNA_2 2194817 tRNA +1 59632 59707 76 validated/Curated no Ala tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:46:23 no tRNA Ala anticodon TGC. vladimir NMV_23S_2 2194881 rRNA +1 60103 63005 2903 validated/Curated no ribosomal RNA 23S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:03:27 vladimir NMV_5S_2 2194885 rRNA +1 63099 63215 117 validated/Curated no ribosomal RNA 5S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:03:35 vladimir NMV_0057 2191019 CDS +2 63416 63715 300 validated/Curated no comE1 DNA-binding competence protein ComE1 1c : Function from experimental evidences in the studied genus f : factor 11 : Membrane 2018-01-11 15:33:53 no 11325945 ComE is a DNA-binding protein involved in neisserial competence. The comE gene is present in four copies in the genome, located downstream of each of the rRNA operons. 1 vladimir 0.232258 0.2430 0.303226 0.221505 0.546237 0.453763 0.264516 0.206452 0.341935 0.187097 0.548387 0.451613 0.251613 0.277419 0.174194 0.296774 0.451613 0.548387 0.180645 0.245161 0.393548 0.180645 0.63871 0.36129 0.552379 16543.035 0.055844 0.331169 0.512987 0.207792 0.084416 0.636364 0.363636 0.233766 0.175325 0.058442 10.152702 8.857143 NMV_0058 2191020 CDS +3 63984 65105 1122 validated/Curated no dnaJ chaperone protein DnaJ 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2020-02-19 13:18:50 no Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating denatured proteins. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyses its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. 1 vladimir 0.258467 0.2148 0.302139 0.224599 0.516934 0.483066 0.264706 0.192513 0.390374 0.152406 0.582888 0.417112 0.339572 0.203209 0.23262 0.224599 0.435829 0.564171 0.171123 0.248663 0.283422 0.296791 0.532086 0.467914 0.622175 40550.24 -0.57748 0.329759 0.517426 0.163539 0.093834 0.530831 0.469169 0.297587 0.163539 0.134048 8.005257 9.731903 NMV_0059 2191021 CDS +3 65301 67319 2019 validated/Curated no putative oligopeptide transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-11 15:35:24 no Belongs to the oligopeptide transporter (OPT) superfamily. 1 vladimir 0.17583 0.2382 0.310054 0.275879 0.548291 0.451709 0.240713 0.153046 0.384844 0.221397 0.53789 0.46211 0.170877 0.257058 0.185736 0.38633 0.442793 0.557207 0.115899 0.304606 0.359584 0.219911 0.66419 0.33581 0.680772 70267.285 0.822917 0.369048 0.53125 0.294643 0.10119 0.717262 0.282738 0.125 0.06994 0.05506 8.527458 8.501488 NMV_0060 2191022 CDS -2 67363 67920 558 validated/Curated no rfbC1 dTDP-4-dehydrorhamnose 3,5-epimerase (dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-L-rhamnose synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 5.1.3.13 DTDPDEHYDRHAMEPIM-RXN DTDPRHAMSYN-PWY$OANTIGEN-PWY 2020-02-21 15:55:02 no Catalyses the following reaction: dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-L-rhamnose. It is the third of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.263441 0.2832 0.25448 0.198925 0.537634 0.462366 0.22043 0.22043 0.365591 0.193548 0.586022 0.413978 0.344086 0.215054 0.172043 0.268817 0.387097 0.612903 0.225806 0.413978 0.225806 0.134409 0.639785 0.360215 0.670642 20812.73 -0.374054 0.27027 0.508108 0.2 0.140541 0.556757 0.443243 0.254054 0.12973 0.124324 5.819252 9.362162 NMV_0061 2191023 CDS -3 67965 68831 867 validated/Curated no rfbA1 glucose-1-phosphate thymidylyltransferase (dTDP-glucose synthase; dTDP-glucose pyrophosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 2.7.7.24 DTDPGLUCOSEPP-RXN DTDPRHAMSYN-PWY$ECASYN-PWY$OANTIGEN-PWY 2020-02-21 15:55:29 no Catalyses the following reaction: dTTP + alpha-D-glucose 1-phosphate <=> diphosphate + dTDP-glucose. It is the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.253749 0.2791 0.254902 0.212226 0.534025 0.465975 0.242215 0.214533 0.349481 0.193772 0.564014 0.435986 0.321799 0.211073 0.16955 0.297578 0.380623 0.619377 0.197232 0.411765 0.245675 0.145329 0.657439 0.342561 0.733065 32046.295 -0.135417 0.28125 0.475694 0.236111 0.118056 0.572917 0.427083 0.229167 0.111111 0.118056 5.361992 9.163194 NMV_0062 2191024 CDS -1 68894 69961 1068 validated/Curated no rfbB1 dTDP-glucose 4,6-dehydratase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 4.2.1.46 DTDPGLUCDEHYDRAT-RXN DTDPRHAMSYN-PWY$ECASYN-PWY$OANTIGEN-PWY 2020-02-21 15:55:46 no Catalyses the following reaction: dTDP-glucose <=> dTDP-4-dehydro-6-deoxy-D-glucose + H(2)O. It is the second of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.237828 0.2959 0.245318 0.220974 0.541198 0.458802 0.22191 0.227528 0.370787 0.179775 0.598315 0.401685 0.325843 0.227528 0.176966 0.269663 0.404494 0.595506 0.16573 0.432584 0.188202 0.213483 0.620787 0.379213 0.743977 39839.35 -0.303662 0.278873 0.512676 0.222535 0.132394 0.552113 0.447887 0.261972 0.129577 0.132394 5.387413 9.842254 NMV_0063 2191025 CDS -3 70077 71096 1020 validated/Curated no galE UDP-glucose 4-epimerase (galactowaldenase; UDP-galactose 4-epimerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 5.1.3.2 UDPGLUCEPIM-RXN PWY-6317 2018-01-29 17:04:33 no Catalyses the following reaction: UDP-glucose <=> UDP-galactose. UDP-glucose and UDP-galactose are precursors of glucose- and galactose-containing exopolysaccharides. 1 vladimir 0.234314 0.2333 0.272549 0.259804 0.505882 0.494118 0.267647 0.191176 0.344118 0.197059 0.535294 0.464706 0.285294 0.229412 0.2 0.285294 0.429412 0.570588 0.15 0.279412 0.273529 0.297059 0.552941 0.447059 0.726838 37046.61 -0.149853 0.309735 0.539823 0.227139 0.103245 0.572271 0.427729 0.215339 0.109145 0.106195 5.680077 9.40118 NMV_0065 2191027 CDS +1 71479 72435 957 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms ph : phenotype 2 : Cytoplasmic 2018-01-11 15:43:16 no 12618369 Might be involved in the synthesis of the polysialic acid capsule. The mutant is sensitive to complement-mediated lysis. 3 vladimir 0.335423 0.1411 0.192268 0.331243 0.333333 0.666667 0.322884 0.15674 0.253918 0.266458 0.410658 0.589342 0.376176 0.178683 0.137931 0.30721 0.316614 0.683386 0.30721 0.087774 0.184953 0.420063 0.272727 0.727273 0.479741 36981.365 -0.281761 0.22956 0.40566 0.22327 0.163522 0.531447 0.468553 0.261006 0.163522 0.097484 9.326836 8.745283 NMV_0066 2191028 CDS -3 72486 73868 1383 validated/Curated no oatC capsular polysaccharide O-acetyltransferase OatC 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2020-02-19 13:21:07 no 14651624 Catalyses capsule O-acetylation at the sialic acid residues. Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. Also contains a Sigma-70 factors family signature 2. 3 vladimir 0.384671 0.1685 0.119306 0.327549 0.28778 0.71222 0.394794 0.138829 0.195228 0.27115 0.334056 0.665944 0.394794 0.206074 0.084599 0.314534 0.290672 0.709328 0.364425 0.160521 0.078091 0.396963 0.238612 0.761388 0.500089 53270.625 -0.184348 0.243478 0.404348 0.234783 0.143478 0.506522 0.493478 0.232609 0.130435 0.102174 8.63192 8.445652 NMV_0067 2191029 CDS -2 73897 75375 1479 validated/Curated no siaD synE alpha-2,9-polysialyltransferase 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 6.7 : Capsule (M and K antigens) ; 2018-01-11 15:46:02 no 12578835, 7830552 Catalyses the polycondensation of alpha-2,9-linked sialic acid during the synthesis of polysialic acid capsule in serogroup C strains. 3 vladimir 0.368492 0.1826 0.133198 0.315754 0.315754 0.684246 0.369168 0.192698 0.196755 0.241379 0.389452 0.610548 0.389452 0.194726 0.085193 0.330629 0.279919 0.720081 0.346856 0.160243 0.117647 0.375254 0.27789 0.72211 0.537582 57525.705 -0.229675 0.211382 0.388211 0.235772 0.162602 0.51626 0.48374 0.231707 0.148374 0.083333 9.396797 8.398374 NMV_0069 2191031 CDS -1 75455 76504 1050 validated/Curated no siaC synC sialic acid synthase (N-acetylneuraminate synthase; N-acetylneuraminic acid synthase) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2.5.1.56 N-ACETYLNEURAMINATE-SYNTHASE-RXN$RXN-9988 PWY-6139 2018-01-11 15:46:53 no 7830552, 8045888 Catalyses the following reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O <=> phosphate + N-acetylneuraminate. It is the second of the three steps in the formation of CMP-NeuAc, the nucleotide sugar donor used by sialyltransferases. 3 vladimir 0.317143 0.1962 0.211429 0.275238 0.407619 0.592381 0.302857 0.142857 0.368571 0.185714 0.511429 0.488571 0.354286 0.211429 0.154286 0.28 0.365714 0.634286 0.294286 0.234286 0.111429 0.36 0.345714 0.654286 0.661076 38346.19 -0.263324 0.283668 0.501433 0.217765 0.091691 0.547278 0.452722 0.283668 0.137536 0.146132 5.331764 9.412607 NMV_0070 2191032 CDS -1 76505 77191 687 validated/Curated no siaB synB N-acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthetase; CMP-sialic acid synthetase) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2.7.7.43 ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN$RXN-9990 PWY-6139 2018-01-11 15:49:38 no 7830552 Catalyses the following reaction: CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. It is the last of the three steps in the formation of CMP-NeuAc, the nucleotide sugar donor used by sialyltransferases. 3 vladimir 0.317322 0.2242 0.177584 0.280932 0.401747 0.598253 0.310044 0.231441 0.28821 0.170306 0.519651 0.480349 0.318777 0.253275 0.131004 0.296943 0.384279 0.615721 0.323144 0.187773 0.113537 0.375546 0.30131 0.69869 0.478612 24891.435 -0.134649 0.298246 0.495614 0.245614 0.078947 0.517544 0.482456 0.22807 0.122807 0.105263 6.050392 8.776316 NMV_0071 2191033 CDS -1 77195 78328 1134 validated/Curated no siaA synA, synX UDP-N-acetylglucosamine 2-epimerase (uridine diphosphate-N-acetylglucosamine-2-epimerase; UDP-GlcNAc-2-epimerase) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 5.1.3.14 RXN-9987$UDPGLCNACEPIM-RXN ECASYN-PWY$PWY-6139 2018-01-11 15:54:43 no 7830552 Catalyses the following reaction: UDP-N-acetyl-D-glucosamine <=> UDP-N-acetyl-D-mannosamine. It is the first of the three steps in the formation of CMP-NeuAc, the nucleotide sugar donor used by sialyltransferases. 3 vladimir 0.325397 0.2011 0.179012 0.294533 0.380071 0.619929 0.314815 0.179894 0.304233 0.201058 0.484127 0.515873 0.335979 0.21164 0.153439 0.298942 0.365079 0.634921 0.325397 0.21164 0.079365 0.383598 0.291005 0.708995 0.592331 42306.58 -0.234218 0.281167 0.461538 0.225464 0.127321 0.525199 0.474801 0.254642 0.135279 0.119363 5.890388 9.320955 NMV_0072 2191034 CDS +3 78471 79646 1176 validated/Curated no ctrA polysialic acid capsule export outer-membrane lipoprotein CtrA 1b : Function from experimental evidences in the studied species t : transporter 7 : Outer membrane protein 2018-01-11 15:55:06 no 1371768, 2493648 3 vladimir 0.232993 0.1794 0.287415 0.30017 0.466837 0.533163 0.244898 0.188776 0.372449 0.193878 0.561224 0.438776 0.255102 0.25 0.173469 0.321429 0.423469 0.576531 0.19898 0.09949 0.316327 0.385204 0.415816 0.584184 0.600896 41915.32 0.076471 0.317136 0.57289 0.258312 0.074169 0.578005 0.421995 0.176471 0.102302 0.074169 9.412071 9.299233 NMV_0073 2191035 CDS +2 79661 80824 1164 validated/Curated no ctrB polysialic acid capsule export inner-membrane protein CtrB 1b : Function from experimental evidences in the studied species t : transporter 5 : Inner membrane protein 2018-01-11 15:55:28 no 2493648 1 vladimir 0.253436 0.1985 0.271478 0.276632 0.469931 0.530069 0.25 0.203608 0.329897 0.216495 0.533505 0.466495 0.337629 0.229381 0.141753 0.291237 0.371134 0.628866 0.17268 0.162371 0.342784 0.322165 0.505155 0.494845 0.648523 43390.72 -0.295607 0.276486 0.459948 0.235142 0.090439 0.503876 0.496124 0.245478 0.126615 0.118863 7.067665 8.97416 NMV_0074 2191036 CDS +1 80824 81621 798 validated/Curated no ctrC polysialic acid capsule export inner-membrane protein CtrC 1b : Function from experimental evidences in the studied species t : transporter 5 : Inner membrane protein 2018-01-11 15:56:27 no 2493648 1 vladimir 0.220551 0.1667 0.263158 0.349624 0.429825 0.570175 0.304511 0.131579 0.281955 0.281955 0.413534 0.586466 0.184211 0.203008 0.169173 0.443609 0.37218 0.62782 0.172932 0.165414 0.338346 0.323308 0.503759 0.496241 0.67006 30195.24 0.769057 0.25283 0.418868 0.29434 0.154717 0.709434 0.290566 0.14717 0.09434 0.05283 9.544304 9.275472 NMV_0075 2191037 CDS +3 81618 82268 651 validated/Curated no ctrD polysialic acid capsule export ATP-binding protein CtrD 1b : Function from experimental evidences in the studied species t : transporter 9 : Periplasmic 7.6.2.12 2020-04-21 13:34:10 no 2493648 1 vladimir 0.25192 0.2043 0.265745 0.278034 0.470046 0.529954 0.276498 0.165899 0.308756 0.248848 0.474654 0.525346 0.341014 0.175115 0.184332 0.299539 0.359447 0.640553 0.138249 0.271889 0.304147 0.285714 0.576037 0.423963 0.666367 24843.635 -0.28287 0.268519 0.430556 0.208333 0.143519 0.537037 0.462963 0.287037 0.157407 0.12963 8.046272 9.425926 NMV_0076 2191038 CDS +3 82332 84605 2274 validated/Curated no putative RNA-binding protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-11 15:59:28 no Contains a S1 RNA-binding domain, originally identified in ribosomal protein S1, a RNase H-like fold and RuvA domain 2-like motif. Is likely to function as an alternative to RuvC in processing the DNA intermediate of homologous recombination, termed Holliday junction. 1 vladimir 0.236148 0.3047 0.287599 0.171504 0.592348 0.407652 0.222955 0.248021 0.408971 0.120053 0.656992 0.343008 0.324538 0.234829 0.162269 0.278364 0.397098 0.602902 0.16095 0.431398 0.291557 0.116095 0.722955 0.277045 0.699332 83082.34 -0.301585 0.282695 0.498018 0.239102 0.06605 0.531044 0.468956 0.297226 0.151915 0.14531 5.997734 9.457067 NMV_0078 2191040 fCDS +3 84636 85418 783 validated/Curated pseudo dcmH cytosine-specific methyltransferase (pseudogene part 1) 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 2.1.1.37 DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-11 16:00:05 no 9321671 Catalyses the following reaction: S-adenosyl-L-methionine + DNA <=> S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. Is the modification methylase of a restriction-modification system. 3 vladimir 0.318893 0.2022 0.196149 0.282792 0.398315 0.601685 0.296029 0.234657 0.270758 0.198556 0.505415 0.494585 0.32852 0.198556 0.184116 0.288809 0.382671 0.617329 0.33213 0.173285 0.133574 0.361011 0.306859 0.693141 0.502505 31189.445 -0.349275 0.268116 0.460145 0.202899 0.137681 0.532609 0.467391 0.235507 0.148551 0.086957 9.213722 9.42029 NMV_0080 2191042 fCDS +1 85411 85638 228 validated/Curated pseudo dcmH cytosine-specific methyltransferase (pseudogene part 2) 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 2.1.1.37 DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-11 16:00:23 no 9321671 Catalyses the following reaction: S-adenosyl-L-methionine + DNA <=> S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. Is the modification methylase of a restriction-modification system. 3 vladimir 0.326984 0.1968 0.196825 0.279365 0.393651 0.606349 0.32381 0.171429 0.304762 0.2 0.47619 0.52381 0.314286 0.238095 0.114286 0.333333 0.352381 0.647619 0.342857 0.180952 0.171429 0.304762 0.352381 0.647619 0.561226 11565.025 0.084615 0.278846 0.5 0.259615 0.086538 0.538462 0.461538 0.201923 0.125 0.076923 9.073586 9.230769 NMV_0081 2191043 CDS +2 85631 85975 345 validated/Curated partial damH truncated adenine-specific methyltransferase (N-terminal third of the protein) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-27 17:37:23 no 9321671 Catalyses the following reaction: S-adenosyl-L-methionine + DNA adenine <=> S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. Is the modification methylase of a restriction-modification system. 3 vladimir 0.333333 0.1738 0.193732 0.299145 0.367521 0.632479 0.299145 0.145299 0.324786 0.230769 0.470085 0.529915 0.42735 0.17094 0.128205 0.273504 0.299145 0.700855 0.273504 0.205128 0.128205 0.393162 0.333333 0.666667 0.664473 13280.415 -0.372414 0.241379 0.474138 0.198276 0.155172 0.534483 0.465517 0.258621 0.12069 0.137931 5.014641 9.456897 NMV_0082 2191044 CDS +2 86057 86674 618 validated/Curated partial galE truncated UDP-glucose 4-epimerase (missing the N-terminal third of the protein) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 5.1.3.2 UDPGLUCEPIM-RXN PWY-6317 2018-01-29 17:03:43 no Catalyses the following reaction: UDP-glucose <=> UDP-galactose. UDP-glucose and UDP-galactose are precursors of glucose- and galactose-containing exopolysaccharides. 1 vladimir 0.240487 0.2405 0.270928 0.248097 0.511416 0.488584 0.255708 0.205479 0.333333 0.205479 0.538813 0.461187 0.296804 0.255708 0.191781 0.255708 0.447489 0.552511 0.16895 0.260274 0.287671 0.283105 0.547945 0.452055 0.717239 24180.575 -0.329817 0.298165 0.522936 0.188073 0.105505 0.582569 0.417431 0.224771 0.114679 0.110092 5.8106 10.004587 NMV_0083 2191045 CDS +3 86790 87857 1068 validated/Curated no rfbB2 dTDP-glucose 4,6-dehydratase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 4.2.1.46 DTDPGLUCDEHYDRAT-RXN DTDPRHAMSYN-PWY$ECASYN-PWY$OANTIGEN-PWY 2020-02-21 15:56:24 no Catalyses the following reaction: dTDP-glucose <=> dTDP-4-dehydro-6-deoxy-D-glucose + H(2)O. Is the second of the four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.237828 0.2959 0.245318 0.220974 0.541198 0.458802 0.22191 0.227528 0.370787 0.179775 0.598315 0.401685 0.325843 0.227528 0.176966 0.269663 0.404494 0.595506 0.16573 0.432584 0.188202 0.213483 0.620787 0.379213 0.743977 39839.35 -0.303662 0.278873 0.512676 0.222535 0.132394 0.552113 0.447887 0.261972 0.129577 0.132394 5.387413 9.842254 NMV_0084 2191046 CDS +2 87920 88786 867 validated/Curated no rfbA2 glucose-1-phosphate thymidylyltransferase (dTDP-glucose synthase; dTDP-glucose pyrophosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 2.7.7.24 DTDPGLUCOSEPP-RXN DTDPRHAMSYN-PWY$ECASYN-PWY$OANTIGEN-PWY 2020-02-21 15:56:40 no Catalyses the following reaction: dTTP + alpha-D-glucose 1-phosphate <=> diphosphate + dTDP-glucose. Is the first of the four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.267062 0.2671 0.254204 0.211672 0.521266 0.478734 0.252226 0.219585 0.332344 0.195846 0.551929 0.448071 0.326409 0.210682 0.172107 0.290801 0.382789 0.617211 0.222552 0.37092 0.25816 0.148368 0.62908 0.37092 0.674428 37751.695 -0.248214 0.270833 0.464286 0.223214 0.119048 0.556548 0.443452 0.241071 0.127976 0.113095 7.134209 9.25 NMV_0085 2191047 CDS +1 88831 89370 540 validated/Curated no rfbC2 dTDP-4-dehydrorhamnose 3,5-epimerase (dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-L-rhamnose synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 5.1.3.13 DTDPDEHYDRHAMEPIM-RXN DTDPRHAMSYN-PWY$OANTIGEN-PWY 2020-02-21 15:56:56 no Catalyses the following reaction: dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-L-rhamnose. Is the third of the four enzymes involved in the biosynthesis of dTDP-L-rhamnose, which is a component of the bacterial cell wall. 2 vladimir 0.264815 0.2741 0.257407 0.203704 0.531481 0.468519 0.222222 0.188889 0.383333 0.205556 0.572222 0.427778 0.344444 0.211111 0.161111 0.283333 0.372222 0.627778 0.227778 0.422222 0.227778 0.122222 0.65 0.35 0.715327 20018.83 -0.275419 0.268156 0.52514 0.206704 0.145251 0.569832 0.430168 0.24581 0.117318 0.128492 5.184044 9.385475 NMV_0086 2191048 CDS +3 89394 91508 2115 validated/Curated no lipA polysialic acid capsule modification protein LipA 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-03-22 17:17:25 no 8326861 Involved in the phospholipid modification of the capsular polysaccharide, which is required for its anchoring to the cell surface. 2 vladimir 0.258156 0.3097 0.207092 0.225059 0.516785 0.483215 0.249645 0.278014 0.285106 0.187234 0.563121 0.436879 0.331915 0.229787 0.158865 0.279433 0.388652 0.611348 0.192908 0.421277 0.177305 0.208511 0.598582 0.401418 0.671625 79606.965 -0.329972 0.264205 0.46733 0.224432 0.127841 0.539773 0.460227 0.245739 0.144886 0.100852 8.819374 9.208807 NMV_0087 2191049 CDS +1 91645 92904 1260 validated/Curated no lipB polysialic acid capsule modification protein LipB 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-03-22 17:18:24 no 8326861 Involved in the phospholipid modification of the capsular polysaccharide, which is required for its anchoring to the cell surface 2 vladimir 0.265873 0.3048 0.184127 0.245238 0.488889 0.511111 0.266667 0.27381 0.269048 0.190476 0.542857 0.457143 0.361905 0.204762 0.138095 0.295238 0.342857 0.657143 0.169048 0.435714 0.145238 0.25 0.580952 0.419048 0.71565 48676.68 -0.361814 0.210024 0.458234 0.205251 0.195704 0.556086 0.443914 0.24821 0.152745 0.095465 8.543266 9.472554 NMV_0088 2191050 CDS +1 93274 94680 1407 validated/Curated no conserved hypothetical TPR-containing protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-01-11 16:08:57 no Contains tetratrico peptide repeat (TPR) structural motifs, which mediate protein-protein interactions and the assembly of multiprotein complexes. 2 vladimir 0.257996 0.3454 0.229566 0.167022 0.574982 0.425018 0.144989 0.319829 0.379531 0.15565 0.69936 0.30064 0.373134 0.309168 0.142857 0.17484 0.452026 0.547974 0.255864 0.407249 0.166311 0.170576 0.573561 0.426439 0.688591 51586.665 -0.43141 0.350427 0.457265 0.153846 0.151709 0.581197 0.418803 0.224359 0.132479 0.09188 6.434807 10.055556 NMV_0089 2191051 CDS +2 94898 96112 1215 validated/Curated no gltS sodium/glutamate symporter (glutamate permease) 2a : Function from experimental evidences in other organisms t : transporter 11 : Membrane 4.2.A.27 : The Glutamate:Na+ Symporter (GltS) Family ; 2020-02-19 13:24:46 no Catalyses the sodium-dependent uptake of extracellular glutamate. 1 vladimir 0.186831 0.2436 0.288889 0.280658 0.53251 0.46749 0.234568 0.165432 0.392593 0.207407 0.558025 0.441975 0.204938 0.237037 0.160494 0.397531 0.397531 0.602469 0.120988 0.328395 0.31358 0.237037 0.641975 0.358025 0.701048 43197.915 0.709158 0.331683 0.532178 0.277228 0.136139 0.693069 0.306931 0.15099 0.079208 0.071782 6.246819 8.690594 NMV_0090 2191052 CDS +1 96211 97227 1017 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2007-10-23 16:50:02 no 1 vladimir 0.251721 0.2734 0.301868 0.173058 0.575221 0.424779 0.218289 0.218289 0.430678 0.132743 0.648968 0.351032 0.333333 0.259587 0.171091 0.235988 0.430678 0.569322 0.20354 0.342183 0.303835 0.150442 0.646018 0.353982 0.603562 36858.055 -0.411834 0.316568 0.517751 0.201183 0.06213 0.529586 0.470414 0.289941 0.127219 0.162722 4.861153 9.893491 NMV_0091 2191053 CDS +2 97238 97435 198 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-22 17:19:48 no 2 vladimir 0.323232 0.2424 0.272727 0.161616 0.515152 0.484848 0.318182 0.166667 0.393939 0.121212 0.560606 0.439394 0.348485 0.212121 0.19697 0.242424 0.409091 0.590909 0.30303 0.348485 0.227273 0.121212 0.575758 0.424242 0.649814 7291.98 -0.681538 0.261538 0.476923 0.184615 0.076923 0.507692 0.492308 0.307692 0.153846 0.153846 5.793404 10.169231 NMV_0092 2191054 CDS -2 97861 99261 1401 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 7 : Outer membrane protein 2018-03-22 17:21:59 no Homologous to the OmpP1/FadL family of proteins. 2 vladimir 0.264811 0.3262 0.240542 0.168451 0.566738 0.433262 0.299786 0.171306 0.372591 0.156317 0.543897 0.456103 0.325482 0.282655 0.169165 0.222698 0.45182 0.54818 0.169165 0.524625 0.179872 0.126338 0.704497 0.295503 0.769661 50515.695 -0.351717 0.362661 0.575107 0.175966 0.130901 0.532189 0.467811 0.244635 0.152361 0.092275 9.368385 8.95279 NMV_0093 2191055 CDS -3 99576 101048 1473 validated/Curated no pykA pyruvate kinase II (PK-2) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 1.3.6 : Aerobic respiration ; 2.7.1.40 PEPDEPHOS-RXN ANAGLYCOLYSIS-PWY$ANARESP1-PWY$FERMENTATION-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-31 15:20:59 no Catalyses the following reaction, which is the final step of glycolysis: ATP + pyruvate <=> ADP + phosphoenolpyruvate. 2 vladimir 0.235574 0.3082 0.2926 0.163612 0.600815 0.399185 0.285132 0.193483 0.425662 0.095723 0.619145 0.380855 0.272912 0.236253 0.193483 0.297352 0.429735 0.570265 0.148676 0.494908 0.258656 0.09776 0.753564 0.246436 0.769743 52432.575 -0.025102 0.336735 0.546939 0.25102 0.055102 0.544898 0.455102 0.259184 0.12449 0.134694 5.271629 9.653061 NMV_0094 2191056 fCDS +2 101309 101761 453 validated/Curated pseudo IS1016 group transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:06:15 no 3 vladimir 0.313373 0.1896 0.207585 0.289421 0.397206 0.602794 0.287425 0.197605 0.299401 0.215569 0.497006 0.502994 0.329341 0.197605 0.209581 0.263473 0.407186 0.592814 0.323353 0.173653 0.113772 0.389222 0.287425 0.712575 0.563289 19091.065 -0.44759 0.295181 0.46988 0.180723 0.162651 0.512048 0.487952 0.26506 0.174699 0.090361 9.693733 9.73494 NMV_0095 2191057 fCDS +3 101760 101951 192 validated/Curated pseudo IS1016 group transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:06:30 no 3 vladimir 0.316239 0.2009 0.188034 0.294872 0.388889 0.611111 0.320513 0.25641 0.205128 0.217949 0.461538 0.538462 0.384615 0.141026 0.179487 0.294872 0.320513 0.679487 0.24359 0.205128 0.179487 0.371795 0.384615 0.615385 0.517997 9160.25 -0.522078 0.194805 0.363636 0.207792 0.168831 0.480519 0.519481 0.311688 0.233766 0.077922 10.136253 9.649351 NMNmiscRNA0175 54921367 misc_RNA -1 102019 102183 165 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:58:15 28334889 Function unknown. vladimir NMV_0097 2191059 CDS +1 102355 102552 198 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2007-10-23 16:51:12 no 3 vladimir 0.282828 0.1566 0.257576 0.30303 0.414141 0.585859 0.318182 0.166667 0.348485 0.166667 0.515152 0.484848 0.227273 0.19697 0.257576 0.318182 0.454545 0.545455 0.30303 0.106061 0.166667 0.424242 0.272727 0.727273 0.515411 7207.99 -0.129231 0.323077 0.523077 0.215385 0.107692 0.538462 0.461538 0.230769 0.138462 0.092308 9.546013 9.861538 NMNmiscRNA0153 54918980 misc_RNA -1 102551 102731 181 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 11:18:24 28334889 Function unknown. vladimir NMV_0099 2191061 CDS +3 102951 103187 237 validated/Curated no putative bacteriocin/pheromone 3 : Putative function from multiple computational evidences f : factor 10 : Secreted 2018-01-11 16:16:05 no Could be a pheromone or a bacteriocin toxic to closely related bacteria. Processing of the N-terminal region up to the GG cleavage motif occurs together with export by a neighbouring ABC transporter. 3 vladimir 0.295359 0.1477 0.236287 0.320675 0.383966 0.616034 0.265823 0.113924 0.367089 0.253165 0.481013 0.518987 0.329114 0.177215 0.21519 0.278481 0.392405 0.607595 0.291139 0.151899 0.126582 0.43038 0.278481 0.721519 0.655635 8318.025 -0.282051 0.358974 0.538462 0.166667 0.153846 0.551282 0.448718 0.205128 0.141026 0.064103 9.575813 7.935897 NMV_0102 2191064 CDS +1 103975 104127 153 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2007-10-23 16:51:34 no 3 vladimir 0.267974 0.1961 0.267974 0.267974 0.464052 0.535948 0.294118 0.117647 0.372549 0.215686 0.490196 0.509804 0.215686 0.235294 0.27451 0.27451 0.509804 0.490196 0.294118 0.235294 0.156863 0.313726 0.392157 0.607843 0.545545 5300.805 -0.004 0.38 0.6 0.14 0.16 0.68 0.32 0.12 0.1 0.02 10.284187 9.7 NMV_0104 2191066 CDS +2 104411 105676 1266 validated/Curated no putative bacteriocin/pheromone secretion membrane fusion protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2020-02-19 12:45:48 no Belongs to the bacterial RTX (repeats in toxin) secretion protein D family. Probably involved in the secretion of neighbouring bacteriocins/pheromones. 3 vladimir 0.349921 0.1967 0.177725 0.275671 0.374408 0.625592 0.329384 0.2109 0.267773 0.191943 0.478673 0.521327 0.369668 0.184834 0.132701 0.312796 0.317536 0.682464 0.350711 0.194313 0.132701 0.322275 0.327014 0.672986 0.588436 47845.44 -0.305226 0.23753 0.406176 0.258907 0.095012 0.491686 0.508314 0.256532 0.154394 0.102138 9.446571 8.67696 NMV_0105 2191067 fCDS +1 105679 106236 558 validated/Curated pseudo putative bacteriocin/pheromone secretion/processing ATP-binding protein (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 3.4.22.- 2020-02-19 12:44:57 no Belongs to the MEROPS cysteine peptidase family C39 and to the ATP-binding cassette ABC-type family. Probably involved in the secretion and the proteolytic maturation of neighbouring bacteriocins/pheromones. 3 vladimir 0.318996 0.1918 0.177419 0.311828 0.369176 0.630824 0.327957 0.172043 0.231183 0.268817 0.403226 0.596774 0.301075 0.182796 0.150538 0.365591 0.333333 0.666667 0.327957 0.22043 0.150538 0.301075 0.370968 0.629032 0.437244 21117.08 0.107568 0.254054 0.416216 0.275676 0.118919 0.556757 0.443243 0.237838 0.145946 0.091892 9.099113 8.648649 NMV_0106 2191068 fCDS +2 106193 107764 1572 validated/Curated pseudo putative bacteriocin/pheromone secretion/processing ATP-binding protein (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 3.4.22.- 2020-02-19 12:45:25 no Belongs to the MEROPS cysteine peptidase family C39 and to the ATP-binding cassette ABC-type family. Probably involved in the secretion and the proteolytic maturation of neighbouring bacteriocins/pheromones. 3 vladimir 0.332061 0.1559 0.176845 0.335242 0.332697 0.667303 0.337786 0.171756 0.269084 0.221374 0.44084 0.55916 0.311069 0.171756 0.131679 0.385496 0.303435 0.696565 0.347328 0.124046 0.129771 0.398855 0.253817 0.746183 0.487171 59257.63 0.195602 0.240918 0.422562 0.300191 0.120459 0.554493 0.445507 0.212237 0.110899 0.101338 5.895195 8.497132 NMV_0107 2191069 CDS -1 107846 107989 144 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2007-10-23 16:52:10 no 3 vladimir 0.479167 0.1528 0.229167 0.138889 0.381944 0.618056 0.333333 0.229167 0.3125 0.125 0.541667 0.458333 0.625 0.145833 0.125 0.104167 0.270833 0.729167 0.479167 0.083333 0.25 0.1875 0.333333 0.666667 0.723514 5857.3 -2.114894 0.148936 0.255319 0.06383 0.085106 0.255319 0.744681 0.489362 0.255319 0.234043 6.805122 9.787234 NMV_0109 2191071 fCDS +2 108215 108532 318 validated/Curated pseudo IS1016 group transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:07:04 no 3 vladimir 0.316092 0.1810 0.224138 0.278736 0.405172 0.594828 0.284483 0.189655 0.327586 0.198276 0.517241 0.482759 0.336207 0.172414 0.224138 0.267241 0.396552 0.603448 0.327586 0.181034 0.12069 0.37069 0.301724 0.698276 0.557556 13087.5 -0.457391 0.278261 0.469565 0.2 0.147826 0.547826 0.452174 0.252174 0.182609 0.069565 10.086906 9.965217 NMV_0110 2191072 fCDS +3 108531 108695 165 validated/Curated pseudo IS1016 group transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:07:20 no 3 vladimir 0.272727 0.1919 0.186869 0.348485 0.378788 0.621212 0.257576 0.212121 0.212121 0.318182 0.424242 0.575758 0.30303 0.181818 0.19697 0.318182 0.378788 0.621212 0.257576 0.181818 0.151515 0.409091 0.333333 0.666667 0.541273 7881.72 -0.201538 0.246154 0.415385 0.2 0.215385 0.492308 0.507692 0.246154 0.138462 0.107692 6.911186 9.661538 NMV_0111 2191073 CDS +3 108972 109490 519 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2007-10-23 17:05:54 no 1 vladimir 0.127168 0.1946 0.406551 0.271676 0.601156 0.398844 0.17341 0.17341 0.421965 0.231214 0.595376 0.404624 0.156069 0.225434 0.219653 0.398844 0.445087 0.554913 0.052023 0.184971 0.578035 0.184971 0.763006 0.236994 0.514382 18189.715 0.797093 0.325581 0.587209 0.319767 0.087209 0.715116 0.284884 0.133721 0.081395 0.052326 9.639793 9.186047 NMV_0112 2191074 CDS -3 109818 110144 327 validated/Curated no putative peptidase 3 : Putative function from multiple computational evidences e : enzyme 6 : Inner membrane-associated 2018-01-11 16:20:25 no Belongs to the MEROPS cysteine peptidase family C39, which are involved in the proteolytic maturation of bacteriocins. 1 vladimir 0.3125 0.1713 0.208333 0.30787 0.37963 0.62037 0.284722 0.166667 0.298611 0.25 0.465278 0.534722 0.340278 0.194444 0.131944 0.333333 0.326389 0.673611 0.3125 0.152778 0.194444 0.340278 0.347222 0.652778 0.635758 16260.08 -0.155944 0.244755 0.447552 0.216783 0.132867 0.552448 0.447552 0.237762 0.125874 0.111888 6.332695 9.146853 NMV_0113 2191075 CDS -3 110394 110630 237 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-09 13:01:56 no 3 vladimir 0.308017 0.1224 0.105485 0.464135 0.227848 0.772152 0.341772 0.101266 0.139241 0.417722 0.240506 0.759494 0.253165 0.177215 0.050633 0.518987 0.227848 0.772152 0.329114 0.088608 0.126582 0.455696 0.21519 0.78481 0.490174 9223.105 1.253846 0.192308 0.320513 0.346154 0.24359 0.769231 0.230769 0.115385 0.102564 0.012821 9.36219 7.935897 NMV_0114 2191076 CDS -3 110727 111428 702 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 5 : Inner membrane protein 2007-10-23 17:10:18 no 3 vladimir 0.316239 0.1738 0.223647 0.286325 0.397436 0.602564 0.34188 0.115385 0.358974 0.183761 0.474359 0.525641 0.282051 0.260684 0.162393 0.294872 0.423077 0.576923 0.324786 0.145299 0.149573 0.380342 0.294872 0.705128 0.587068 24739.41 0.201717 0.377682 0.527897 0.206009 0.111588 0.618026 0.381974 0.150215 0.090129 0.060086 8.913048 9.042918 NMV_0115 2191077 CDS -3 111555 111713 159 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2007-10-23 17:10:30 no 2 vladimir 0.157233 0.3774 0.213836 0.251572 0.591195 0.408805 0.207547 0.283019 0.283019 0.226415 0.566038 0.433962 0.113208 0.339623 0.264151 0.283019 0.603774 0.396226 0.150943 0.509434 0.09434 0.245283 0.603774 0.396226 0.551424 5368.245 0.671154 0.461538 0.596154 0.25 0.038462 0.692308 0.307692 0.134615 0.096154 0.038462 8.779213 9.192308 NMV_0116 2191078 CDS -1 111710 112552 843 validated/Curated no putative N-acetyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-22 17:24:14 no Belongs to the family of the Gcn5-related acetyltransferases (GNATs). 2 vladimir 0.252669 0.3381 0.236062 0.173191 0.57414 0.42586 0.238434 0.245552 0.359431 0.156584 0.604982 0.395018 0.33452 0.206406 0.192171 0.266904 0.398577 0.601423 0.185053 0.562278 0.156584 0.096085 0.718861 0.281139 0.759361 31648.795 -0.373929 0.278571 0.482143 0.210714 0.117857 0.514286 0.485714 0.314286 0.178571 0.135714 7.299553 9.957143 NMV_0117 2191079 CDS +3 112788 113708 921 validated/Curated no pyrB aspartate carbamoyltransferase (aspartate transcarbamylase; ATCase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; 2.1.3.2 ASPCARBTRANS-RXN PWY-5686 2018-01-11 16:22:35 no Catalyses the following reaction in the pyrimidine biosynthesis pathway: carbamoyl phosphate + L-aspartate <=> phosphate + N-carbamoyl-L-aspartate. 1 vladimir 0.219327 0.2899 0.284473 0.206298 0.574376 0.425624 0.228013 0.2443 0.34202 0.185668 0.586319 0.413681 0.302932 0.247557 0.175896 0.273616 0.423453 0.576547 0.127036 0.37785 0.335505 0.159609 0.713355 0.286645 0.65284 34178.825 -0.273203 0.294118 0.470588 0.215686 0.101307 0.545752 0.454248 0.27451 0.143791 0.130719 6.097816 9.627451 NMV_0118 2191080 CDS +3 113718 114176 459 validated/Curated no pyrI aspartate carbamoyltransferase regulatory chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; ASPCARBTRANS-RXN PWY-5686 2020-02-19 13:28:09 no Involved in allosteric regulation of aspartate carbamoyltransferase. 2 vladimir 0.276688 0.2985 0.259259 0.165577 0.557734 0.442266 0.313726 0.215686 0.339869 0.130719 0.555556 0.444444 0.352941 0.189542 0.189542 0.267974 0.379085 0.620915 0.163399 0.490196 0.248366 0.098039 0.738562 0.261438 0.675808 16903.795 -0.35 0.276316 0.513158 0.223684 0.105263 0.519737 0.480263 0.302632 0.190789 0.111842 9.115456 9.407895 NMV_0119 2191081 CDS +1 114247 114906 660 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-21 11:20:23 no 1 vladimir 0.238739 0.2417 0.288288 0.231231 0.53003 0.46997 0.22973 0.189189 0.355856 0.225225 0.545045 0.454955 0.301802 0.265766 0.117117 0.315315 0.382883 0.617117 0.184685 0.27027 0.391892 0.153153 0.662162 0.337838 0.610424 24722.77 0.039367 0.298643 0.429864 0.21267 0.131222 0.58371 0.41629 0.253394 0.140271 0.113122 7.195625 8.968326 NMV_0120 2191082 CDS -3 114969 116186 1218 validated/Curated no tsaP secretin-associated protein TsaP 1c : Function from experimental evidences in the studied genus f : factor 9 : Periplasmic 6.5 : Pilus ; 2020-04-25 14:08:06 no 24556993 Is a secretin-associated protein, which binds peptidoglycan. It is not required for pilus biogenesis in N. meningitidis, but it modulates pilus-mediated properties. 2 vladimir 0.251232 0.3071 0.255337 0.186371 0.562397 0.437603 0.275862 0.251232 0.317734 0.155172 0.568966 0.431034 0.317734 0.238916 0.17734 0.26601 0.416256 0.583744 0.160099 0.431034 0.270936 0.137931 0.70197 0.29803 0.698088 45565.06 -0.511852 0.266667 0.498765 0.214815 0.091358 0.508642 0.491358 0.271605 0.145679 0.125926 7.975883 9.595062 NMV_0121 2191083 CDS +3 116370 116873 504 validated/Curated no def peptide deformylase (PDF; polypeptide deformylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.3 : Posttranslational modification ; 3.5.1.88 3.5.1.88-RXN 2020-02-19 12:50:34 no Catalyses the following reaction: formyl-L-methionyl peptide + H(2)O <=> formate + methionyl peptide. Is an essential metalloenzyme required for the removal of the formyl groups at the N-terminus of nascent polypeptide chains. 1 vladimir 0.251984 0.2560 0.299603 0.19246 0.555556 0.444444 0.255952 0.232143 0.386905 0.125 0.619048 0.380952 0.357143 0.166667 0.14881 0.327381 0.315476 0.684524 0.142857 0.369048 0.363095 0.125 0.732143 0.267857 0.645975 19114.38 -0.295808 0.209581 0.42515 0.275449 0.077844 0.502994 0.497006 0.347305 0.173653 0.173653 5.609474 9.928144 NMV_0122 2191084 CDS +2 116960 117886 927 validated/Curated no fmt methionyl-tRNA formyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.2.9 METHIONYL-TRNA-FORMYLTRANSFERASE-RXN 2020-04-22 13:43:28 no Transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF-2 and by impairing its binding to EFTU-GTP. 1 vladimir 0.218986 0.2869 0.317152 0.176915 0.604099 0.395901 0.20712 0.239482 0.456311 0.097087 0.695793 0.304207 0.28479 0.265372 0.177994 0.271845 0.443366 0.556634 0.165049 0.355987 0.317152 0.161812 0.673139 0.326861 0.719091 32969.645 -0.063636 0.314935 0.529221 0.227273 0.055195 0.61039 0.38961 0.253247 0.12987 0.123377 6.047401 10.035714 NMV_0123 2191085 CDS +2 117965 119224 1260 validated/Curated no rmsB sun ribosomal RNA small subunit methyltransferase B (rRNA (cytosine-C(5)-)-methyltransferase; 16S rRNA m5C967 methyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1.176 RXN-11591 2018-01-22 12:52:32 no Catalyses the following reaction: S-adenosyl-L-methionine + cytosine(967) in 16S rRNA <=> S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA. 1 vladimir 0.222222 0.2833 0.3 0.194444 0.583333 0.416667 0.195238 0.269048 0.378571 0.157143 0.647619 0.352381 0.333333 0.247619 0.166667 0.252381 0.414286 0.585714 0.138095 0.333333 0.354762 0.17381 0.688095 0.311905 0.649184 46319.07 -0.274702 0.291169 0.498807 0.217184 0.102625 0.568019 0.431981 0.272076 0.157518 0.114558 8.374825 9.634845 NMV_0124 2191086 CDS +3 119190 119789 600 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2020-04-23 18:23:27 no Belongs to the DUF4390 family of proteins, which are not functionally characterised. 1 vladimir 0.233886 0.2873 0.270718 0.208103 0.558011 0.441989 0.265193 0.237569 0.314917 0.18232 0.552486 0.447514 0.287293 0.270718 0.176796 0.265193 0.447514 0.552486 0.149171 0.353591 0.320442 0.176796 0.674033 0.325967 0.601616 19684.525 -0.225 0.327778 0.527778 0.227778 0.088889 0.533333 0.466667 0.216667 0.116667 0.1 8.170067 8.572222 NMV_0125 2191087 CDS +2 119789 121909 2121 validated/Curated no putative two-component system sensor protein 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2.7.13.3 2.7.13.3-RXN 2018-01-11 16:30:19 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins, which, in turn, function as molecular switches that control diverse effector activities. 1 vladimir 0.220179 0.2645 0.308817 0.206506 0.573314 0.426686 0.230552 0.216407 0.39604 0.157001 0.612447 0.387553 0.27157 0.240453 0.181047 0.306931 0.421499 0.578501 0.158416 0.336634 0.349364 0.155587 0.685997 0.314003 0.61209 76552.155 0.083711 0.31728 0.509915 0.249292 0.096317 0.601983 0.398017 0.233711 0.126062 0.107649 7.018211 9.174221 NMV_0126 2191088 CDS +3 121902 123179 1278 validated/Curated no putative two-component system transcriptional regulator protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-11 16:31:34 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. Contains a sigma-54 factor interaction domain. 1 vladimir 0.230829 0.2480 0.324726 0.196401 0.57277 0.42723 0.232394 0.220657 0.415493 0.131455 0.63615 0.36385 0.307512 0.21831 0.183099 0.29108 0.401408 0.598592 0.152582 0.305164 0.375587 0.166667 0.680751 0.319249 0.627059 46422.14 -0.132 0.294118 0.487059 0.237647 0.075294 0.571765 0.428235 0.261176 0.12 0.141176 5.062386 9.642353 NMV_0127 2191089 CDS +3 123270 124457 1188 validated/Curated no dprA smf DNA processing chain A (DprA) 2b : Function from indirect experimental evidences (e.g. phenotypes) ph : phenotype 2 : Cytoplasmic 2020-02-21 16:00:16 no Belongs to a family of bacterial proteins including DNA processing protein A (DprA) from Streptococcus pneumoniae and Smf, the Bacillus subtilis orthologue. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation. 1 vladimir 0.207912 0.2811 0.319024 0.191919 0.600168 0.399832 0.217172 0.244949 0.39899 0.138889 0.643939 0.356061 0.244949 0.292929 0.19697 0.265152 0.489899 0.510101 0.161616 0.305556 0.361111 0.171717 0.666667 0.333333 0.628589 41972.47 -0.048608 0.35443 0.536709 0.207595 0.073418 0.61519 0.38481 0.222785 0.113924 0.108861 5.873512 9.602532 NMV_0128 2191090 CDS +1 124483 124944 462 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-22 17:30:21 no Members of this family of uncharacterized proteins are often named Smg. 2 vladimir 0.270563 0.2684 0.261905 0.199134 0.530303 0.469697 0.298701 0.220779 0.357143 0.123377 0.577922 0.422078 0.324675 0.188312 0.123377 0.363636 0.311688 0.688312 0.188312 0.396104 0.305195 0.11039 0.701299 0.298701 0.703302 17104.07 0.085621 0.235294 0.45098 0.267974 0.071895 0.568627 0.431373 0.254902 0.065359 0.189542 4.036461 9.633987 NMV_0129 2191091 CDS +3 125016 127322 2307 validated/Curated no topA DNA topoisomerase 1 (Omega protein; relaxing enzyme; untwisting enzyme; swivelase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.1.1.1 : DNA bending, supercoiling, inversion ; 5.6.2.1 5.99.1.2-RXN 2020-04-21 13:34:49 no Catalyses the ATP-independent breakage of single-stranded DNA, followed by passage and rejoining of another single-stranded DNA region. This reaction brings about the conversion of one topological isomer of DNA into another: e.g., relaxation of superhelical turns; interconversion of simple and knotted rings of single-stranded DNA; and intertwisting of single-stranded rings of complementary sequences. 2 vladimir 0.295189 0.3004 0.234504 0.169918 0.534894 0.465106 0.282185 0.219766 0.345904 0.152146 0.56567 0.43433 0.375813 0.215865 0.179454 0.228869 0.395319 0.604681 0.227568 0.46554 0.178153 0.128739 0.643693 0.356307 0.751679 87025.855 -0.624609 0.276042 0.470052 0.178385 0.106771 0.503906 0.496094 0.309896 0.166667 0.143229 8.112495 9.695313 NMV_0130 2191092 CDS -3 127395 128090 696 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 11:55:03 no 1 vladimir 0.310345 0.2270 0.222701 0.239943 0.449713 0.550287 0.297414 0.189655 0.293103 0.219828 0.482759 0.517241 0.396552 0.168103 0.168103 0.267241 0.336207 0.663793 0.237069 0.323276 0.206897 0.232759 0.530172 0.469828 0.63335 26806.25 -0.596537 0.233766 0.450216 0.164502 0.168831 0.515152 0.484848 0.272727 0.142857 0.12987 6.104225 9.38961 NMV_0131 2191093 CDS -2 128110 128661 552 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-02-13 11:55:18 no 3 vladimir 0.29529 0.1757 0.15942 0.369565 0.335145 0.664855 0.331522 0.163043 0.195652 0.309783 0.358696 0.641304 0.228261 0.190217 0.179348 0.402174 0.369565 0.630435 0.326087 0.173913 0.103261 0.396739 0.277174 0.722826 0.437151 21230.55 0.581421 0.262295 0.387978 0.327869 0.163934 0.612022 0.387978 0.196721 0.142077 0.054645 9.743721 8.125683 NMV_0132 2191094 CDS +2 128780 129157 378 validated/Curated no putative DNA-binding protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-11 16:38:27 no Contains a helix-turn-helix (HTH) motif found in DNA-binding proteins. 1 vladimir 0.312169 0.1614 0.296296 0.230159 0.457672 0.542328 0.309524 0.150794 0.349206 0.190476 0.5 0.5 0.396825 0.134921 0.15873 0.309524 0.293651 0.706349 0.230159 0.198413 0.380952 0.190476 0.579365 0.420635 0.672959 14308.01 -0.4712 0.232 0.344 0.216 0.072 0.504 0.496 0.344 0.16 0.184 5.140892 9.36 NMV_0133 2191095 CDS +3 129246 129815 570 validated/Curated no rsmD ribosomal RNA small subunit methyltransferase D 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1.171 RXN0-6515 2018-01-11 16:39:49 no 17189261 Catalyses the following reaction: S-adenosyl-L-methionine + guanine(966) in 16S rRNA <=> S-adenosyl-L-homocysteine + N2-methylguanine(966) in 16S rRNA. 1 vladimir 0.249123 0.2474 0.289474 0.214035 0.536842 0.463158 0.242105 0.236842 0.336842 0.184211 0.573684 0.426316 0.3 0.194737 0.226316 0.278947 0.421053 0.578947 0.205263 0.310526 0.305263 0.178947 0.615789 0.384211 0.577728 21024.08 -0.303704 0.291005 0.502646 0.222222 0.100529 0.539683 0.460317 0.238095 0.132275 0.10582 8.83828 9.137566 NMV_0134 2191096 CDS +2 129938 130189 252 validated/Curated no putative ferredoxin 3 : Putative function from multiple computational evidences c : carrier 1 : Unknown 1.4.3 : Electron carrier ; 2020-02-19 12:59:28 no Belongs to the family of Fe-4S ferredoxins, which are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. 1 vladimir 0.293651 0.2659 0.230159 0.210317 0.496032 0.503968 0.25 0.214286 0.321429 0.214286 0.535714 0.464286 0.464286 0.154762 0.130952 0.25 0.285714 0.714286 0.166667 0.428571 0.238095 0.166667 0.666667 0.333333 0.705473 9552.39 -0.395181 0.216867 0.46988 0.204819 0.096386 0.518072 0.481928 0.301205 0.072289 0.228916 3.978462 11.024096 NMV_tRNA_3 2194818 tRNA +1 130286 130369 84 validated/Curated no Tyr tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:46:42 no tRNA Tyr anticodon GTA. vladimir NMV_tRNA_4 2194819 tRNA +1 130400 130473 74 validated/Curated no Gly tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:46:52 no tRNA Gly anticodon TCC. vladimir NMV_tRNA_5 2194820 tRNA +1 130483 130557 75 validated/Curated no Thr tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:47:01 no tRNA Thr anticodon GGT. vladimir NMV_0135 2191097 CDS +1 130606 131790 1185 validated/Curated no tuf1 elongation factor Tu (EF-Tu) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-11 16:44:47 no Belongs to the GTP-binding elongation factor family. This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. 2 vladimir 0.265823 0.2675 0.254852 0.211814 0.522363 0.477637 0.255696 0.189873 0.43038 0.124051 0.620253 0.379747 0.306329 0.235443 0.167089 0.291139 0.402532 0.597468 0.235443 0.377215 0.167089 0.220253 0.544304 0.455696 0.868082 42907.275 -0.135533 0.307107 0.525381 0.228426 0.091371 0.563452 0.436548 0.284264 0.13198 0.152284 5.069221 9.913706 NMV_tRNA_6 2194821 tRNA +1 131797 131872 76 validated/Curated no Trp tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:47:11 no tRNA Trp anticodon CCA. vladimir NMV_0136 2191098 CDS +3 131988 132266 279 validated/Curated no secE protein translocase SecE subunit 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:00:19 no Part of the prokaryotic protein translocation apparatus essential for protein export. 3 vladimir 0.286738 0.1326 0.240143 0.340502 0.37276 0.62724 0.258065 0.096774 0.376344 0.268817 0.473118 0.526882 0.301075 0.225806 0.11828 0.354839 0.344086 0.655914 0.301075 0.075269 0.225806 0.397849 0.301075 0.698925 0.565165 10625.815 0.026087 0.23913 0.48913 0.23913 0.163043 0.543478 0.456522 0.271739 0.141304 0.130435 6.799034 8.728261 NMV_0137 2191099 CDS +1 132268 132804 537 validated/Curated no nusG transcription termination/antitermination protein NusG 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2020-04-22 13:00:59 no Is a component of the transcription complex, which interacts with the termination factor Rho and RNA polymerase. Is a transcriptional elongation factor involved in transcription termination and antitermination. 3 vladimir 0.292365 0.1508 0.290503 0.266294 0.441341 0.558659 0.284916 0.189944 0.379888 0.145251 0.569832 0.430168 0.363128 0.145251 0.189944 0.301676 0.335196 0.664804 0.22905 0.117318 0.301676 0.351955 0.418994 0.581006 0.484863 20549.605 -0.557303 0.191011 0.44382 0.235955 0.095506 0.5 0.5 0.303371 0.151685 0.151685 6.057762 10.140449 NMV_0138 2191100 CDS +2 132905 133339 435 validated/Curated no rplK 50S ribosomal protein L11 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:48:39 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.25977 0.2023 0.243678 0.294253 0.445977 0.554023 0.296552 0.158621 0.372414 0.172414 0.531034 0.468966 0.255172 0.324138 0.131034 0.289655 0.455172 0.544828 0.227586 0.124138 0.227586 0.42069 0.351724 0.648276 0.741745 14952.925 0.088889 0.347222 0.576389 0.229167 0.041667 0.618056 0.381944 0.201389 0.125 0.076389 9.717766 8.534722 NMV_0139 2191101 CDS +1 133339 134034 696 validated/Curated no rplA 50S ribosomal protein L1 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:50:11 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.271552 0.1983 0.247126 0.283046 0.445402 0.554598 0.271552 0.133621 0.456897 0.137931 0.590517 0.409483 0.293103 0.288793 0.133621 0.284483 0.422414 0.577586 0.25 0.172414 0.150862 0.426724 0.323276 0.676724 0.780366 24100.68 0.01039 0.34632 0.601732 0.238095 0.047619 0.575758 0.424242 0.246753 0.142857 0.103896 9.587242 8.874459 NMV_0141 2191103 CDS +2 134264 134764 501 validated/Curated no rplJ 50S ribosomal protein L10 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:51:04 no Is one of the proteins from the large ribosomal subunit. 1 vladimir 0.245509 0.2016 0.271457 0.281437 0.473054 0.526946 0.227545 0.143713 0.467066 0.161677 0.610778 0.389222 0.293413 0.281437 0.131737 0.293413 0.413174 0.586826 0.215569 0.179641 0.215569 0.389222 0.39521 0.60479 0.751297 17575.525 0.13494 0.349398 0.536145 0.246988 0.054217 0.584337 0.415663 0.240964 0.126506 0.114458 8.152229 9.23494 NMV_0142 2191104 CDS +2 134822 135193 372 validated/Curated no rplL 50S ribosomal protein L7/L12 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:51:43 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.298387 0.1801 0.260753 0.260753 0.44086 0.55914 0.241935 0.064516 0.580645 0.112903 0.645161 0.354839 0.33871 0.266129 0.104839 0.290323 0.370968 0.629032 0.314516 0.209677 0.096774 0.379032 0.306452 0.693548 0.893256 12621.88 0.104878 0.349593 0.560976 0.252033 0.02439 0.585366 0.414634 0.308943 0.121951 0.186992 4.604912 8.804878 NMV_0143 2191105 CDS +2 135383 139561 4179 validated/Curated no rpoB DNA-directed RNA polymerase beta chain (RNAP beta subunit; transcriptase beta chain; RNA polymerase beta subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.2 : Transcription related ; 2.7.7.6 DNA-DIRECTED-RNA-POLYMERASE-RXN 2020-02-20 13:02:56 no Subunit of the RNA polymerase, which catalyses the transcription of DNA into RNA. 1 vladimir 0.257717 0.2345 0.267528 0.240249 0.502034 0.497966 0.249821 0.188801 0.383345 0.178033 0.572146 0.427854 0.336683 0.203877 0.171572 0.287868 0.375449 0.624551 0.186648 0.31084 0.247667 0.254846 0.558507 0.441493 0.785368 155526.425 -0.391882 0.262931 0.485632 0.229885 0.085489 0.51796 0.48204 0.299569 0.145115 0.154454 5.363167 9.664511 NMV_0144 2191106 CDS +3 139713 143888 4176 validated/Curated no rpoC DNA-directed RNA polymerase beta' chain (RNAP beta' subunit; transcriptase beta' chain; RNA polymerase beta' subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.2 : Transcription related ; 2.7.7.6 DNA-DIRECTED-RNA-POLYMERASE-RXN 2020-02-20 13:03:43 no Subunit of the RNA polymerase, which catalyses the transcription of DNA into RNA. 1 vladimir 0.258621 0.2407 0.266044 0.234674 0.506705 0.493295 0.252874 0.200431 0.387931 0.158764 0.588362 0.411638 0.309626 0.213362 0.176724 0.300287 0.390086 0.609914 0.213362 0.30819 0.233477 0.244971 0.541667 0.458333 0.825057 153727.8 -0.226743 0.279655 0.488857 0.244428 0.074047 0.540618 0.459382 0.28972 0.153127 0.136592 6.893349 9.601725 NMV_0146 2191108 CDS +3 144180 144437 258 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-02-13 12:14:53 no 1 vladimir 0.205426 0.2519 0.310078 0.232558 0.562016 0.437984 0.244186 0.232558 0.418605 0.104651 0.651163 0.348837 0.197674 0.267442 0.209302 0.325581 0.476744 0.523256 0.174419 0.255814 0.302326 0.267442 0.55814 0.44186 0.597296 8925.96 0.137647 0.305882 0.6 0.223529 0.047059 0.658824 0.341176 0.211765 0.082353 0.129412 4.540718 9.894118 NMV_0147 2191109 CDS +2 144434 144583 150 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 12:15:07 no 1 vladimir 0.34 0.2067 0.213333 0.24 0.42 0.58 0.42 0.16 0.16 0.26 0.32 0.68 0.34 0.18 0.24 0.24 0.42 0.58 0.26 0.28 0.24 0.22 0.52 0.48 0.50487 5859.54 -0.710204 0.265306 0.408163 0.122449 0.204082 0.489796 0.510204 0.244898 0.204082 0.040816 10.288994 8.816327 NMV_0149 2191111 CDS +3 144762 145133 372 validated/Curated no rpsL 30S ribosomal protein S12 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:56:45 no Is one of the proteins from the small ribosomal subunit. 1 vladimir 0.287634 0.2688 0.233871 0.209677 0.502688 0.497312 0.266129 0.258065 0.322581 0.153226 0.580645 0.419355 0.322581 0.209677 0.233871 0.233871 0.443548 0.556452 0.274194 0.33871 0.145161 0.241935 0.483871 0.516129 0.810661 13707.45 -0.662602 0.276423 0.528455 0.219512 0.073171 0.512195 0.487805 0.300813 0.243902 0.056911 10.648201 9.97561 NMV_0150 2191112 CDS +3 145251 145721 471 validated/Curated no rpsG 30S ribosomal protein S7 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:57:05 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.278132 0.2272 0.269639 0.225053 0.496815 0.503185 0.248408 0.191083 0.414013 0.146497 0.605096 0.394904 0.305732 0.197452 0.210191 0.286624 0.407643 0.592357 0.280255 0.292994 0.184713 0.242038 0.477707 0.522293 0.820624 17655.895 -0.50641 0.237179 0.455128 0.211538 0.070513 0.532051 0.467949 0.365385 0.230769 0.134615 10.332253 10.147436 NMV_0151 2191113 CDS +3 145740 147845 2106 validated/Curated no fusA elongation factor G (EF-G) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2020-04-22 13:23:36 no Is a large five-domain GTPase that promotes the directional movement of mRNA and tRNAs on the ribosome in a GTP-dependent manner. 1 vladimir 0.261159 0.2403 0.259734 0.238841 0.5 0.5 0.249288 0.182336 0.421652 0.146724 0.603989 0.396011 0.31339 0.237892 0.168091 0.280627 0.405983 0.594017 0.220798 0.30057 0.189459 0.289174 0.490028 0.509971 0.833823 77202.79 -0.295435 0.293866 0.504993 0.2097 0.082739 0.546362 0.453638 0.28388 0.131241 0.152639 5.084175 10.029957 NMV_0152 2191114 CDS +3 147933 149117 1185 validated/Curated no tuf2 elongation factor Tu (EF-Tu) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-11 16:58:07 no Belongs to the GTP-binding elongation factor family. This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. 2 vladimir 0.26076 0.2751 0.26076 0.203376 0.535865 0.464135 0.255696 0.194937 0.43038 0.118987 0.625316 0.374684 0.306329 0.235443 0.167089 0.291139 0.402532 0.597468 0.220253 0.394937 0.18481 0.2 0.579747 0.420253 0.858733 42907.275 -0.135533 0.307107 0.525381 0.228426 0.091371 0.563452 0.436548 0.284264 0.13198 0.152284 5.069221 9.913706 NMV_0153 2191115 CDS +2 149135 149446 312 validated/Curated no rpsJ 30S ribosomal protein S10 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:58:29 no Is one of the proteins from the small ribosomal subunit. 1 vladimir 0.298077 0.2532 0.217949 0.230769 0.471154 0.528846 0.317308 0.25 0.317308 0.115385 0.567308 0.432692 0.336538 0.230769 0.125 0.307692 0.355769 0.644231 0.240385 0.278846 0.211538 0.269231 0.490385 0.509615 0.867496 11806.35 -0.356311 0.213592 0.446602 0.271845 0.058252 0.495146 0.504854 0.330097 0.194175 0.135922 9.569191 9.378641 NMV_0154 2191116 CDS +2 149567 150355 789 validated/Curated partial truncated ISNme1 transposase (N-terminal 80% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-11 16:58:44 no Belongs to the IS5 family. 2 vladimir 0.288973 0.3029 0.217997 0.190114 0.520913 0.479087 0.277567 0.292776 0.281369 0.148289 0.574144 0.425856 0.372624 0.197719 0.18251 0.247148 0.380228 0.619772 0.21673 0.418251 0.190114 0.174905 0.608365 0.391635 0.683471 30180.135 -0.619466 0.259542 0.416031 0.206107 0.118321 0.473282 0.526718 0.305344 0.167939 0.137405 6.539909 9.248092 NMV_0155 2191117 CDS +2 150869 151513 645 validated/Curated no rplC 50S ribosomal protein L3 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:59:03 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.246512 0.2357 0.268217 0.249612 0.503876 0.496124 0.24186 0.181395 0.446512 0.130233 0.627907 0.372093 0.283721 0.232558 0.2 0.283721 0.432558 0.567442 0.213953 0.293023 0.15814 0.334884 0.451163 0.548837 0.823623 22706.945 -0.258879 0.341121 0.588785 0.219626 0.065421 0.53271 0.46729 0.257009 0.163551 0.093458 10.032433 9.518692 NMV_0156 2191118 CDS +1 151513 152133 621 validated/Curated no rplD 50S ribosomal protein L4 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:59:23 no Is one of the proteins from the large ribosomal subunit. 1 vladimir 0.285024 0.2238 0.236715 0.254428 0.460548 0.539452 0.246377 0.217391 0.342995 0.193237 0.560386 0.439614 0.342995 0.241546 0.149758 0.2657 0.391304 0.608696 0.2657 0.21256 0.217391 0.304348 0.429952 0.570048 0.762613 23247.755 -0.493689 0.26699 0.480583 0.218447 0.082524 0.495146 0.504854 0.271845 0.169903 0.101942 9.918678 9.456311 NMV_0157 2191119 CDS +3 152130 152444 315 validated/Curated no rplW 50S ribosomal protein L23 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 16:59:58 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.301587 0.1968 0.238095 0.263492 0.434921 0.565079 0.304762 0.152381 0.4 0.142857 0.552381 0.447619 0.314286 0.27619 0.133333 0.27619 0.409524 0.590476 0.285714 0.161905 0.180952 0.371429 0.342857 0.657143 0.788017 11229.565 -0.173077 0.336538 0.528846 0.230769 0.038462 0.509615 0.490385 0.259615 0.163462 0.096154 9.992271 9.067308 NMV_0158 2191120 CDS +2 152450 153283 834 validated/Curated no rplB 50S ribosomal protein L2 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:00:21 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.256595 0.2626 0.256595 0.224221 0.519185 0.480815 0.28777 0.230216 0.381295 0.100719 0.611511 0.388489 0.291367 0.233813 0.258993 0.215827 0.492806 0.507194 0.190647 0.323741 0.129496 0.356115 0.453237 0.546763 0.8246 30096.32 -0.599278 0.32491 0.541516 0.187726 0.075812 0.545126 0.454874 0.292419 0.216606 0.075812 10.736427 10.465704 NMV_0159 2191121 CDS +2 153290 153568 279 validated/Curated no rpsS 30S ribosomal protein S19 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:00:39 no Is one of the proteins from the small ribosomal subunit. 1 vladimir 0.290323 0.2401 0.21147 0.258065 0.451613 0.548387 0.333333 0.215054 0.27957 0.172043 0.494624 0.505376 0.322581 0.225806 0.172043 0.27957 0.397849 0.602151 0.215054 0.27957 0.182796 0.322581 0.462366 0.537634 0.803908 10361.745 -0.475 0.271739 0.478261 0.217391 0.119565 0.48913 0.51087 0.347826 0.271739 0.076087 10.69915 8.217391 NMV_0161 2191123 CDS +1 153577 153906 330 validated/Curated no rplV 50S ribosomal protein L22 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:01:00 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.318182 0.1909 0.230303 0.260606 0.421212 0.578788 0.336364 0.172727 0.372727 0.118182 0.545455 0.454545 0.363636 0.2 0.163636 0.272727 0.363636 0.636364 0.254545 0.2 0.154545 0.390909 0.354545 0.645455 0.764262 11908.25 -0.359633 0.275229 0.504587 0.238532 0.055046 0.504587 0.495413 0.302752 0.211009 0.091743 10.284828 9.155963 NMV_0162 2191124 CDS +1 153916 154608 693 validated/Curated no rpsC 30S ribosomal protein S3 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:01:18 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.279942 0.1948 0.255411 0.269841 0.450216 0.549784 0.294372 0.203463 0.359307 0.142857 0.562771 0.437229 0.316017 0.220779 0.207792 0.255411 0.428571 0.571429 0.229437 0.160173 0.199134 0.411255 0.359307 0.640693 0.711301 25796.655 -0.519565 0.282609 0.482609 0.213043 0.078261 0.504348 0.495652 0.304348 0.204348 0.1 10.421867 9.717391 NMV_0163 2191125 CDS +2 154592 155008 417 validated/Curated no rplP 50S ribosomal protein L16 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:01:34 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.273381 0.1990 0.263789 0.263789 0.46283 0.53717 0.28777 0.23741 0.359712 0.115108 0.597122 0.402878 0.28777 0.201439 0.244604 0.266187 0.446043 0.553957 0.244604 0.158273 0.18705 0.410072 0.345324 0.654676 0.734922 15518.585 -0.507971 0.268116 0.434783 0.202899 0.07971 0.565217 0.434783 0.297101 0.210145 0.086957 10.837791 10.23913 NMV_0164 2191126 CDS +1 155008 155199 192 validated/Curated no rpmC 50S ribosomal protein L29 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:01:47 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.34375 0.1562 0.229167 0.270833 0.385417 0.614583 0.3125 0.15625 0.328125 0.203125 0.484375 0.515625 0.390625 0.171875 0.15625 0.28125 0.328125 0.671875 0.328125 0.140625 0.203125 0.328125 0.34375 0.65625 0.727094 7078 -0.634921 0.238095 0.412698 0.238095 0.015873 0.460317 0.539683 0.349206 0.222222 0.126984 10.085625 8.777778 NMV_0165 2191127 CDS +3 155199 155462 264 validated/Curated no rpsQ 30S ribosomal protein S17 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:02:06 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.344697 0.1477 0.219697 0.287879 0.367424 0.632576 0.352273 0.159091 0.329545 0.159091 0.488636 0.511364 0.363636 0.181818 0.147727 0.306818 0.329545 0.670455 0.318182 0.102273 0.181818 0.397727 0.284091 0.715909 0.668154 9830 -0.406897 0.241379 0.494253 0.287356 0.068966 0.436782 0.563218 0.333333 0.218391 0.114943 9.79232 8.609195 NMV_0166 2191128 CDS +2 155684 156052 369 validated/Curated no rplN 50S ribosomal protein L14 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:02:23 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.252033 0.1816 0.260163 0.306233 0.441734 0.558266 0.268293 0.178862 0.398374 0.154472 0.577236 0.422764 0.260163 0.211382 0.195122 0.333333 0.406504 0.593496 0.227642 0.154472 0.186992 0.430894 0.341463 0.658537 0.709001 13374.235 -0.032787 0.262295 0.540984 0.278689 0.040984 0.581967 0.418033 0.278689 0.188525 0.090164 10.588707 9.819672 NMV_0167 2191129 CDS +1 156064 156387 324 validated/Curated no rplX 50S ribosomal protein L24 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:02:59 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.327161 0.1358 0.25 0.287037 0.385802 0.614198 0.37963 0.148148 0.398148 0.074074 0.546296 0.453704 0.351852 0.12037 0.185185 0.342593 0.305556 0.694444 0.25 0.138889 0.166667 0.444444 0.305556 0.694444 0.73757 11666.2 -0.247664 0.205607 0.504673 0.299065 0.028037 0.542056 0.457944 0.308411 0.205607 0.102804 10.23954 9.140187 NMV_0169 2191131 CDS +1 156397 156936 540 validated/Curated no rplE 50S ribosomal protein L5 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:04:33 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.290741 0.1519 0.233333 0.324074 0.385185 0.614815 0.294444 0.138889 0.366667 0.2 0.505556 0.494444 0.316667 0.188889 0.161111 0.333333 0.35 0.65 0.261111 0.127778 0.172222 0.438889 0.3 0.7 0.754762 20321.97 -0.207263 0.234637 0.452514 0.240223 0.094972 0.547486 0.452514 0.312849 0.178771 0.134078 9.491859 9.519553 NMV_0170 2191132 CDS +3 156939 157244 306 validated/Curated no rpsN 30S ribosomal protein S14 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:05:17 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.25817 0.1993 0.25817 0.284314 0.457516 0.542484 0.294118 0.245098 0.323529 0.137255 0.568627 0.431373 0.264706 0.245098 0.254902 0.235294 0.5 0.5 0.215686 0.107843 0.196078 0.480392 0.303922 0.696078 0.74364 11516.16 -0.609901 0.287129 0.425743 0.178218 0.059406 0.524752 0.475248 0.336634 0.267327 0.069307 11.860939 10.29703 NMV_0171 2191133 CDS +3 157260 157652 393 validated/Curated no rpsH 30S ribosomal protein S8 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:06:15 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.282443 0.1603 0.234097 0.323155 0.394402 0.605598 0.305344 0.145038 0.343511 0.206107 0.48855 0.51145 0.274809 0.236641 0.183206 0.305344 0.419847 0.580153 0.267176 0.099237 0.175573 0.458015 0.274809 0.725191 0.674039 14123.005 -0.013077 0.315385 0.5 0.253846 0.046154 0.561538 0.438462 0.253846 0.161538 0.092308 9.733788 9.030769 NMV_0172 2191134 CDS +1 157666 158199 534 validated/Curated no rplF 50S ribosomal protein L6 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:06:46 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.294007 0.1629 0.245318 0.297753 0.40824 0.59176 0.269663 0.140449 0.41573 0.174157 0.55618 0.44382 0.308989 0.224719 0.162921 0.303371 0.38764 0.61236 0.303371 0.123596 0.157303 0.41573 0.280899 0.719101 0.711369 18933.01 -0.117514 0.305085 0.548023 0.237288 0.073446 0.564972 0.435028 0.231638 0.141243 0.090395 9.629753 9.152542 NMV_0173 2191135 CDS +2 158213 158566 354 validated/Curated no rplR 50S ribosomal protein L18 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:07:08 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.288136 0.1723 0.262712 0.276836 0.435028 0.564972 0.262712 0.169492 0.423729 0.144068 0.59322 0.40678 0.29661 0.228814 0.228814 0.245763 0.457627 0.542373 0.305085 0.118644 0.135593 0.440678 0.254237 0.745763 0.633191 12797.19 -0.34359 0.350427 0.504274 0.196581 0.076923 0.512821 0.487179 0.324786 0.222222 0.102564 10.421654 9.717949 NMV_0174 2191136 CDS +2 158585 159103 519 validated/Curated no rpsE 30S ribosomal protein S5 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:07:27 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.285164 0.1715 0.265896 0.277457 0.43738 0.56262 0.300578 0.16763 0.427746 0.104046 0.595376 0.404624 0.289017 0.208092 0.202312 0.300578 0.410405 0.589595 0.265896 0.138728 0.16763 0.427746 0.306358 0.693642 0.665048 18245.415 -0.171512 0.313953 0.540698 0.232558 0.069767 0.569767 0.430233 0.290698 0.197674 0.093023 10.040443 9.453488 NMV_0175 2191137 CDS +3 159096 159281 186 validated/Curated no rpmD 50S ribosomal protein L30 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:07:41 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.295699 0.1559 0.258065 0.290323 0.413978 0.586021 0.33871 0.177419 0.306452 0.177419 0.483871 0.516129 0.290323 0.16129 0.241935 0.306452 0.403226 0.596774 0.258065 0.129032 0.225806 0.387097 0.354839 0.645161 0.660415 6945.9 -0.345902 0.262295 0.409836 0.278689 0.04918 0.47541 0.52459 0.344262 0.229508 0.114754 10.005943 9.786885 NMV_0176 2191138 CDS +1 159283 159717 435 validated/Curated no rplO 50S ribosomal protein L15 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:07:59 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.252874 0.1586 0.275862 0.312644 0.434483 0.565517 0.289655 0.172414 0.4 0.137931 0.572414 0.427586 0.241379 0.227586 0.248276 0.282759 0.475862 0.524138 0.227586 0.075862 0.17931 0.517241 0.255172 0.744828 0.592415 14881.665 -0.057639 0.388889 0.520833 0.236111 0.048611 0.576389 0.423611 0.236111 0.180556 0.055556 11.290565 8.631944 NMV_0177 2191139 CDS +3 159729 161039 1311 validated/Curated no secY protein translocase SecY subunit 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:17:04 no Part of the prokaryotic protein translocation apparatus essential for protein export. 3 vladimir 0.26087 0.1518 0.218154 0.369184 0.369947 0.630053 0.304348 0.146453 0.283753 0.265446 0.430206 0.569794 0.210526 0.237986 0.160183 0.391304 0.398169 0.601831 0.267735 0.070938 0.210526 0.450801 0.281465 0.718535 0.474605 47505.265 0.56445 0.325688 0.472477 0.291284 0.123853 0.635321 0.364679 0.142202 0.09633 0.045872 9.763374 8.197248 NMV_0178 2191140 CDS +1 161044 161262 219 validated/Curated no infA translation initiation factor IF-1 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-11 17:10:01 no Contains a S1-like domain. No specific function has so far been attributed to this initiation factor. However, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3. 3 vladimir 0.3379 0.1644 0.214612 0.283105 0.378995 0.621005 0.369863 0.205479 0.30137 0.123288 0.506849 0.493151 0.328767 0.205479 0.136986 0.328767 0.342466 0.657534 0.315068 0.082192 0.205479 0.39726 0.287671 0.712329 0.473997 8294.395 -0.2875 0.222222 0.416667 0.25 0.097222 0.513889 0.486111 0.319444 0.194444 0.125 9.226967 9.833333 NMV_0178.1 2662677 CDS +3 161283 161396 114 validated/Curated no rpmJ2 50S ribosomal protein L36 type B 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:10:29 Is one of the proteins from the large ribosomal subunit. vladimir NMV_0179 2191141 CDS +2 161462 161824 363 validated/Curated no rpsM 30S ribosomal protein S13 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:11:00 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.267218 0.2039 0.261708 0.267218 0.465565 0.534435 0.297521 0.22314 0.355372 0.123967 0.578512 0.421488 0.297521 0.214876 0.256198 0.231405 0.471074 0.528926 0.206612 0.173554 0.173554 0.446281 0.347107 0.652893 0.692571 13359.025 -0.550833 0.308333 0.483333 0.191667 0.05 0.533333 0.466667 0.325 0.225 0.1 10.421013 10.666667 NMV_0180 2191142 CDS +3 161844 162239 396 validated/Curated no rpsK 30S ribosomal protein S11 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:11:23 no Is one of the proteins from the small ribosomal subunit. 3 vladimir 0.277778 0.2222 0.227273 0.272727 0.449495 0.550505 0.310606 0.189394 0.356061 0.143939 0.545455 0.454545 0.257576 0.30303 0.219697 0.219697 0.522727 0.477273 0.265152 0.174242 0.106061 0.454545 0.280303 0.719697 0.743576 13918.4 -0.407634 0.381679 0.587786 0.183206 0.068702 0.519084 0.480916 0.251908 0.198473 0.053435 11.257774 9.236641 NMV_0181 2191143 CDS +1 162259 162879 621 validated/Curated no rpsD 30S ribosomal protein S4 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:11:48 no Is one of the proteins from the small ribosomal subunit. 1 vladimir 0.254428 0.1820 0.26409 0.299517 0.446055 0.553945 0.202899 0.217391 0.357488 0.222222 0.574879 0.425121 0.328502 0.188406 0.202899 0.280193 0.391304 0.608696 0.231884 0.140097 0.231884 0.396135 0.371981 0.628019 0.731289 23248.905 -0.491262 0.257282 0.451456 0.23301 0.07767 0.509709 0.490291 0.315534 0.199029 0.116505 9.998466 9.378641 NMV_0182 2191144 CDS +2 162905 163891 987 validated/Curated no rpoA DNA-directed RNA polymerase alpha chain (RNAP alpha subunit; transcriptase alpha chain; RNA polymerase alpha subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.2 : Transcription related ; 2.7.7.6 DNA-DIRECTED-RNA-POLYMERASE-RXN 2020-02-20 13:43:21 no Subunit of the RNA polymerase, which catalyses the transcription of DNA into RNA. 3 vladimir 0.256332 0.1733 0.251266 0.319149 0.424519 0.575481 0.237082 0.209726 0.3769 0.176292 0.586626 0.413374 0.316109 0.209726 0.158055 0.316109 0.367781 0.632219 0.215805 0.100304 0.218845 0.465046 0.319149 0.680851 0.697001 36074.705 -0.186585 0.256098 0.496951 0.27439 0.060976 0.52439 0.47561 0.277439 0.125 0.152439 4.941261 9.125 NMV_0183 2191145 CDS +1 163915 164283 369 validated/Curated no rplQ 50S ribosomal protein L17 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-11 17:12:56 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.252033 0.2060 0.257453 0.284553 0.463415 0.536585 0.260163 0.252033 0.325203 0.162602 0.577236 0.422764 0.276423 0.219512 0.219512 0.284553 0.439024 0.560976 0.219512 0.146341 0.227642 0.406504 0.373984 0.626016 0.704745 13801.555 -0.519672 0.254098 0.5 0.229508 0.07377 0.508197 0.491803 0.327869 0.237705 0.090164 11.401222 10.07377 NMV_0185 2191147 CDS +3 164430 165143 714 validated/Curated no minC septum site-determining protein MinC 1c : Function from experimental evidences in the studied genus f : factor 2 : Cytoplasmic 5.1 : Cell division ; 2018-01-11 17:13:38 no 11160816, 15090526 Is part of the MinC, MinD and MinE system, which prevents assembly of Z rings in regions of the cell not covered by the nucleoid, such as the cell poles. MinC is an inhibitor of FtsZ polymerisation, resulting in the inhibition of Z ring assembly in the cell; MinD greatly enhances the inhibitory effects of MinC in vivo; and MinE antagonises the effects of MinC and MinD. 3 vladimir 0.240896 0.1709 0.280112 0.308123 0.45098 0.54902 0.235294 0.184874 0.361345 0.218487 0.546218 0.453782 0.331933 0.210084 0.121849 0.336134 0.331933 0.668067 0.155462 0.117647 0.357143 0.369748 0.47479 0.52521 0.589799 26205.95 -0.008861 0.265823 0.476793 0.265823 0.105485 0.548523 0.451477 0.248945 0.126582 0.122363 5.55735 8.898734 NMV_0186 2191148 CDS +1 165172 165987 816 validated/Curated no minD septum site-determining protein MinD 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 5.1 : Cell division ; 2018-03-22 17:38:26 no 11591668 Is part of the MinC, MinD and MinE system, which prevents assembly of Z rings in regions of the cell not covered by the nucleoid, such as the cell poles. MinC is an inhibitor of FtsZ polymerisation, resulting in the inhibition of Z ring assembly in the cell; MinD greatly enhances the inhibitory effects of MinC in vivo; and MinE antagonises the effects of MinC and MinD. 1 vladimir 0.256127 0.1949 0.273284 0.275735 0.468137 0.531863 0.272059 0.172794 0.378676 0.176471 0.551471 0.448529 0.3125 0.202206 0.172794 0.3125 0.375 0.625 0.183824 0.209559 0.268382 0.338235 0.477941 0.522059 0.658707 29525.73 -0.063469 0.298893 0.494465 0.261993 0.066421 0.542435 0.457565 0.265683 0.132841 0.132841 5.710945 9.04797 NMV_0187 2191149 CDS +1 165991 166254 264 validated/Curated no minE septum formation topological specificity factor MinE 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 5.1 : Cell division ; 2018-01-11 17:14:56 no Is part of the MinC, MinD and MinE system, which prevents assembly of Z rings in regions of the cell not covered by the nucleoid, such as the cell poles. MinC is an inhibitor of FtsZ polymerisation, resulting in the inhibition of Z ring assembly in the cell; MinD greatly enhances the inhibitory effects of MinC in vivo; and MinE antagonises the effects of MinC and MinD. 1 vladimir 0.306818 0.2121 0.231061 0.25 0.443182 0.556818 0.284091 0.227273 0.306818 0.181818 0.534091 0.465909 0.386364 0.181818 0.102273 0.329545 0.284091 0.715909 0.25 0.227273 0.284091 0.238636 0.511364 0.488636 0.609127 10044.28 -0.391954 0.183908 0.37931 0.275862 0.045977 0.482759 0.517241 0.298851 0.149425 0.149425 6.46151 9.241379 NMV_0188 2191150 CDS +1 166258 167178 921 validated/Curated no oxyR hydrogen peroxide-inducible genes transcriptional activator 1c : Function from experimental evidences in the studied genus r : regulator 2 : Cytoplasmic 2018-01-11 17:15:28 no 12496210 Belongs to the LysR family of bacterial transcription regulatory proteins that bind DNA via a helix-turn-helix (HTH) motif. Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione-reductase. 1 vladimir 0.225841 0.2345 0.29316 0.246471 0.527687 0.472313 0.260586 0.234528 0.332248 0.172638 0.566775 0.433225 0.270358 0.237785 0.159609 0.332248 0.397394 0.602606 0.14658 0.23127 0.387622 0.234528 0.618893 0.381107 0.590784 34122.295 0.003268 0.27451 0.457516 0.261438 0.081699 0.54902 0.45098 0.254902 0.130719 0.124183 5.887398 9.434641 NMV_0190 2191152 CDS -3 167508 170345 2838 validated/Curated no valS valine-tRNA ligase (valyl-tRNA synthetase; ValRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.9 VALINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-11 17:17:07 no Catalyses the attachment of valine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.263566 0.2970 0.258633 0.180761 0.555673 0.444327 0.258985 0.207188 0.368922 0.164905 0.57611 0.42389 0.332981 0.22833 0.163848 0.274841 0.392178 0.607822 0.198731 0.455603 0.243129 0.102537 0.698731 0.301268 0.784682 106532.21 -0.341164 0.270899 0.493122 0.205291 0.111111 0.542857 0.457143 0.269841 0.128042 0.141799 5.194832 9.790476 NMV_0191 2191153 CDS -3 170442 171251 810 validated/Curated no zupT zinc transporter ZupT 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 11 : Membrane 4.S.191 : Zn ; 2018-01-11 17:17:46 no Mediates zinc uptake. May also transport other divalent cations 1 vladimir 0.169136 0.2444 0.3 0.28642 0.544444 0.455556 0.214815 0.155556 0.385185 0.244444 0.540741 0.459259 0.181481 0.307407 0.140741 0.37037 0.448148 0.551852 0.111111 0.27037 0.374074 0.244444 0.644444 0.355556 0.691674 28454.2 0.67658 0.360595 0.546468 0.245353 0.133829 0.695167 0.304833 0.152416 0.081784 0.070632 5.956291 8.802974 NMV_0193 2191155 CDS -3 171432 172688 1257 validated/Curated no dadA D-amino acid dehydrogenase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.4.99.6 DALADEHYDROG-RXN$RXN-11193$RXN-12648$RXN0-5259$RXN0-6678$RXN0-6684 ALADEG-PWY 2018-01-11 17:20:26 no Is a FAD flavoenzyme that catalyses the following reaction: D-amino acid + H(2)O + acceptor <=> 2-oxo acid + NH(3) + reduced acceptor. 2 vladimir 0.240255 0.2745 0.272076 0.213206 0.546539 0.453461 0.245823 0.21241 0.350835 0.190931 0.563246 0.436754 0.279236 0.231504 0.21241 0.27685 0.443914 0.556086 0.195704 0.379475 0.252983 0.171838 0.632458 0.367542 0.694689 46666.565 -0.241866 0.311005 0.497608 0.210526 0.110048 0.552632 0.447368 0.255981 0.133971 0.12201 6.465889 9.681818 NMV_0194 2191156 CDS -3 172767 174158 1392 validated/Curated no putative amino-acid symporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.25 : The Alanine/Glycine:Cation symporter (AGCS) Family ; 2020-02-19 14:07:48 no Belongs to the the sodium/alanine symporter family. 1 vladimir 0.196839 0.2493 0.289512 0.264368 0.538793 0.461207 0.269397 0.122845 0.394397 0.213362 0.517241 0.482759 0.189655 0.260776 0.181034 0.368534 0.44181 0.55819 0.131466 0.364224 0.293103 0.211207 0.657328 0.342672 0.756675 48586.14 0.689633 0.37797 0.557235 0.265659 0.11879 0.701944 0.298056 0.12311 0.073434 0.049676 9.018471 8.768898 NMV_0195 2191157 CDS -1 174515 175291 777 validated/Curated no lpxA acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (UDP-N-acetylglucosamine acyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 2.3.1.129 UDPNACETYLGLUCOSAMACYLTRANS-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2018-01-11 17:22:27 no 11742971, 9548250 Catalyses the following reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine <=> [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. Is involved in the biosynthesis of lipid A, a component of lipooligosaccharide (LOS). 2 vladimir 0.238095 0.3488 0.239382 0.173745 0.58816 0.41184 0.285714 0.196911 0.378378 0.138996 0.57529 0.42471 0.293436 0.235521 0.189189 0.281853 0.42471 0.57529 0.135135 0.6139 0.150579 0.100386 0.764479 0.235521 0.761247 28154.785 -0.096124 0.325581 0.542636 0.209302 0.131783 0.581395 0.418605 0.224806 0.124031 0.100775 6.320625 9.953488 NMV_0196 2191158 CDS -2 175378 175827 450 validated/Curated no fabZ 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 4.2.1.59 3-HYDROXYDECANOYL-ACP-DEHYDR-RXN$4.2.1.58-RXN$4.2.1.59-RXN$4.2.1.61-RXN$FABAUNSATDEHYDR-RXN$RXN-10061$RXN-10656$RXN-10660$RXN-11477$RXN-11481$RXN-9520$RXN-9533$RXN-9537$RXN-9557$RXN-9634$RXN-9655$RXN0-2144$RXN1G-320$RXN1G-363$RXN1G-479$RXN1G-517 FASYN-ELONG-PWY$PWY-5971$PWY-5973$PWY-6282$PWY-6519$PWY0-862 2018-01-30 12:45:38 no Is the primary dehydratase involved in fatty-acid elongation during type II or dissociative fatty-acid biosynthesis. 2 vladimir 0.251111 0.3422 0.226667 0.18 0.568889 0.431111 0.266667 0.266667 0.366667 0.1 0.633333 0.366667 0.286667 0.193333 0.153333 0.366667 0.346667 0.653333 0.2 0.566667 0.16 0.073333 0.726667 0.273333 0.686374 16625.88 0.148993 0.228188 0.449664 0.261745 0.09396 0.610738 0.389262 0.248322 0.127517 0.120805 6.164467 9.409396 NMV_0197 2191159 CDS -3 175863 176906 1044 validated/Curated no lpxD UDP-3-O-acylglucosamine N-acyltransferase (UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 2.3.1.- UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2018-01-31 20:52:16 no Catalyses an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] <=> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]. 2 vladimir 0.243295 0.3429 0.260536 0.153257 0.603448 0.396552 0.29023 0.178161 0.416667 0.114943 0.594828 0.405172 0.272988 0.247126 0.218391 0.261494 0.465517 0.534483 0.166667 0.603448 0.146552 0.083333 0.75 0.25 0.747167 36304.46 0.006916 0.389049 0.599424 0.227666 0.095101 0.576369 0.423631 0.21902 0.121037 0.097983 6.229408 9.282421 NMV_0198 2191160 CDS -1 176939 177439 501 validated/Curated no skp ompH chaperone protein Skp (OmpH) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 9 : Periplasmic 2.3.4 : Chaperoning, folding ; 2018-01-11 17:26:45 no Is a homotrimeric periplasmic chaperone for newly synthesised outer-membrane proteins in E. coli. 2 vladimir 0.301397 0.2854 0.241517 0.171657 0.526946 0.473054 0.281437 0.227545 0.347305 0.143713 0.57485 0.42515 0.401198 0.185629 0.161677 0.251497 0.347305 0.652695 0.221557 0.443114 0.215569 0.11976 0.658683 0.341317 0.705984 19130.035 -0.633133 0.253012 0.403614 0.198795 0.084337 0.463855 0.536145 0.313253 0.174699 0.138554 9.226753 9.849398 NMV_0199 2191161 CDS -2 177505 179898 2394 validated/Curated no bamA omp85 outer membrane protein assembly factor BamA (Omp85) 1b : Function from experimental evidences in the studied species m : membrane component 7 : Outer membrane protein 2018-01-30 16:27:16 no 12522254 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. 2 vladimir 0.276525 0.3170 0.240602 0.165831 0.557644 0.442356 0.305764 0.200501 0.334586 0.159148 0.535088 0.464912 0.337093 0.224311 0.185464 0.253133 0.409774 0.590226 0.186717 0.526316 0.201754 0.085213 0.72807 0.27193 0.736013 88494.26 -0.465997 0.316186 0.515684 0.188206 0.116688 0.514429 0.485571 0.240903 0.12798 0.112923 8.52372 9.215809 NMV_0200 2191162 CDS -3 179955 181295 1341 validated/Curated no putative zinc metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 3.1.3.4 : Proteases, cleavage of compounds ; 3.4.24.- 2018-01-11 17:28:35 no Belongs to MEROPS peptidase family M50 (S2P protease family, clan MM). 2 vladimir 0.218494 0.3341 0.258016 0.189411 0.592095 0.407905 0.243848 0.232662 0.375839 0.147651 0.608501 0.391499 0.232662 0.250559 0.210291 0.306488 0.46085 0.53915 0.178971 0.519016 0.187919 0.114094 0.706935 0.293065 0.698372 48005.525 0.116592 0.338565 0.53139 0.246637 0.105381 0.61435 0.38565 0.206278 0.121076 0.085202 9.251854 8.975336 NMV_0201 2191163 CDS -2 181330 182565 1236 validated/Curated no dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 1.1.1.267 DXPREDISOM-RXN NONMEVIPP-PWY 2018-01-11 17:29:10 no Catalyses the following reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + NADPH. Is part of an alternative nonmevalonate pathway for terpenoid biosynthesis. 2 vladimir 0.214346 0.3105 0.276793 0.198312 0.587342 0.412658 0.210127 0.225316 0.410127 0.15443 0.635443 0.364557 0.263291 0.278481 0.167089 0.291139 0.44557 0.55443 0.16962 0.427848 0.253165 0.149367 0.681013 0.318987 0.657958 41898.185 0.108122 0.347716 0.568528 0.228426 0.088832 0.601523 0.398477 0.218274 0.109137 0.109137 5.477776 9.319797 NMV_0202 2191164 CDS -1 182570 183367 798 validated/Curated no cdsA phosphatidate cytidylyltransferase (CDP-diglyceride synthetase; CDP-diglyceride pyrophosphorylase; CDP-diacylglycerol synthase; CDS; CTP:phosphatidate cytidylyltransferase; CDP-DAG synthase; CDP-DG synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.6.1 : Phospholipid ; 2.7.7.41 CDPDIGLYSYN-RXN$RXN0-5515 PWY-5667$PWY-5981$PWY0-1319$PWY4FS-7$PWY4FS-8 2018-01-11 17:30:50 no Catalyses the following reaction: CTP + phosphatidate <=> diphosphate + CDP-diacylglycerol. CDP-diacylglycerol is an important branch point intermediate. 1 vladimir 0.169173 0.2481 0.317043 0.265664 0.565163 0.434837 0.221805 0.184211 0.368421 0.225564 0.552632 0.447368 0.161654 0.206767 0.24812 0.383459 0.454887 0.545113 0.12406 0.353383 0.334586 0.18797 0.68797 0.31203 0.703758 29191.73 0.821509 0.316981 0.509434 0.29434 0.158491 0.766038 0.233962 0.132075 0.086792 0.045283 9.224831 8.935849 NMV_0203 2191165 CDS -2 183370 184116 747 validated/Curated no uppS isoprenyl transferase (undecaprenyl pyrophosphate synthetase; UPP synthetase; di-trans,poly-cis-decaprenylcistransferase; undecaprenyl diphosphate synthase; UDS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 2.5.1.31 RXN-8999 PWY-5785 2018-01-11 17:31:55 no Catalyses the following reaction: CTP + phosphatidate <=> diphosphate + CDP-diacylglycerol. CDP-diacylglycerol is an important branch point intermediate. 2 vladimir 0.255689 0.2651 0.27577 0.203481 0.54083 0.45917 0.26506 0.248996 0.325301 0.160643 0.574297 0.425703 0.317269 0.192771 0.196787 0.293173 0.389558 0.610442 0.184739 0.353414 0.305221 0.156627 0.658635 0.341365 0.701833 28343.425 -0.372984 0.258065 0.419355 0.21371 0.108871 0.524194 0.475806 0.28629 0.157258 0.129032 8.03698 9.612903 NMV_0204 2191166 CDS -1 184172 184729 558 validated/Curated no frr ribosome-recycling factor (ribosome-releasing factor; RRF) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2020-04-22 13:25:53 no Dissociates ribosomes from mRNA after termination of translation, thus ribosomes are recycled and ready for another round of protein synthesis. 1 vladimir 0.301075 0.2742 0.268817 0.155914 0.543011 0.456989 0.290323 0.225806 0.424731 0.05914 0.650538 0.349462 0.365591 0.188172 0.155914 0.290323 0.344086 0.655914 0.247312 0.408602 0.225806 0.11828 0.634409 0.365591 0.771573 20730.01 -0.496216 0.232432 0.47027 0.248649 0.032432 0.486486 0.513514 0.362162 0.183784 0.178378 6.268394 9.918919 NMV_0205 2191167 CDS -2 184909 186036 1128 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-13 12:32:46 no 2 vladimir 0.220745 0.3644 0.254433 0.160461 0.618794 0.381206 0.279255 0.324468 0.292553 0.103723 0.617021 0.382979 0.25266 0.196809 0.228723 0.321809 0.425532 0.574468 0.130319 0.571809 0.242021 0.055851 0.81383 0.18617 0.649089 42444.89 -0.048267 0.296 0.421333 0.245333 0.109333 0.562667 0.437333 0.232 0.16 0.072 10.46064 9.770667 NMV_tRNA_58 2194873 tRNA -1 186110 186185 76 validated/Curated no Thr tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:47:30 no tRNA Thr anticodon CGT. vladimir NMV_0206 2191168 CDS +1 186292 186777 486 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-02-13 12:44:50 no 1 vladimir 0.127572 0.1996 0.401235 0.271605 0.600823 0.399177 0.135802 0.209877 0.425926 0.228395 0.635802 0.364198 0.160494 0.246914 0.203704 0.388889 0.450617 0.549383 0.08642 0.141975 0.574074 0.197531 0.716049 0.283951 0.538129 17473.02 0.756522 0.335404 0.52795 0.273292 0.167702 0.73913 0.26087 0.167702 0.118012 0.049689 10.075157 8.962733 NMV_0207 2191169 CDS +3 186873 187496 624 validated/Curated no rsmG gidB ribosomal RNA small subunit methyltransferase G (GidB) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.170 RXN-11578 2018-01-11 17:35:11 no Catalyses the following reaction: S-adenosyl-L-methionine + guanine(527) in 16S rRNA <=> S-adenosyl-L-homocysteine + N(7)-methylguanine(527) in 16S rRNA. 1 vladimir 0.209936 0.2308 0.336538 0.222756 0.567308 0.432692 0.206731 0.230769 0.418269 0.144231 0.649038 0.350962 0.293269 0.201923 0.182692 0.322115 0.384615 0.615385 0.129808 0.259615 0.408654 0.201923 0.668269 0.331731 0.652463 22785.4 -0.000966 0.2657 0.507246 0.289855 0.072464 0.574879 0.425121 0.280193 0.144928 0.135266 5.980217 9.391304 NMV_0208 2191170 CDS +2 187595 188368 774 validated/Curated no putative ATPase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic ADENOSINETRIPHOSPHATASE-RXN$ATP-PYROPHOSPHATASE-RXN$ATPSYN-RXN$RXN0-1061$RXN0-4261 PWY-6126 2018-01-11 17:35:45 no Contains a CobQ/CobB/MinD/ParA nucleotide-binding domain. Belongs to a family containing various cobyrinic acid a,c-diamide synthases, dethiobiotin synthetases, as well as the plasmid partitioning proteins of the MinD/ParA family. 1 vladimir 0.202842 0.2494 0.347545 0.200258 0.596899 0.403101 0.248062 0.193798 0.426357 0.131783 0.620155 0.379845 0.263566 0.244186 0.186047 0.306202 0.430233 0.569767 0.096899 0.310078 0.430233 0.162791 0.74031 0.25969 0.614028 27161.17 0.162646 0.338521 0.560311 0.272374 0.050584 0.607004 0.392996 0.217899 0.108949 0.108949 5.801949 9.400778 NMV_0209 2191171 CDS -3 189162 189746 585 validated/Curated no rnhB ribonuclease HII (RNase HII) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.26.4 3.1.26.4-RXN 2018-01-11 17:36:24 no Is involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules, carrying out endonucleolytic cleavage to 5'-phospho-monoester. 2 vladimir 0.264957 0.3333 0.239316 0.162393 0.57265 0.42735 0.251282 0.251282 0.389744 0.107692 0.641026 0.358974 0.323077 0.25641 0.133333 0.287179 0.389744 0.610256 0.220513 0.492308 0.194872 0.092308 0.687179 0.312821 0.678547 21187.595 -0.123711 0.28866 0.484536 0.231959 0.103093 0.572165 0.427835 0.283505 0.164948 0.118557 7.307777 9.103093 NMV_0210 2191172 CDS -2 189814 191709 1896 validated/Curated no mnmG gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-11 17:36:58 no Is involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in some tRNAs. 2 vladimir 0.264441 0.3169 0.257552 0.161102 0.574457 0.425543 0.251192 0.251192 0.36725 0.130366 0.618442 0.381558 0.324324 0.216216 0.192369 0.267091 0.408585 0.591415 0.217806 0.483307 0.213037 0.085851 0.696343 0.303657 0.715423 69502.265 -0.394427 0.291401 0.477707 0.214968 0.08758 0.536624 0.463376 0.272293 0.14172 0.130573 6.130394 9.785032 NMV_0211 2191173 CDS -2 192034 193461 1428 validated/Curated no putative amino-acid symporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.25 : The Alanine/Glycine:Cation symporter (AGCS) Family ; 2020-02-19 14:19:10 no Belongs to the the sodium/alanine symporter family 2 vladimir 0.184174 0.2689 0.285714 0.261204 0.554622 0.445378 0.252101 0.184874 0.361345 0.201681 0.546218 0.453782 0.203782 0.22479 0.182773 0.388655 0.407563 0.592437 0.096639 0.397059 0.313025 0.193277 0.710084 0.289916 0.72076 51823.95 0.655158 0.315789 0.498947 0.267368 0.151579 0.707368 0.292632 0.136842 0.08 0.056842 8.611092 8.903158 NMV_0212 2191174 CDS +1 193621 194610 990 validated/Curated no pdxA 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.6 : Pyridoxine (vitamin B6) ; 1.1.1.262 1.1.1.262-RXN PYRIDOXSYN-PWY 2018-01-11 17:37:57 no Catalyses the following reaction, which is important for vitamin B6 biosynthesis: 4-(phosphonooxy)-threonine + NAD(+) <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH. 1 vladimir 0.211111 0.3212 0.284848 0.182828 0.606061 0.393939 0.218182 0.248485 0.418182 0.115152 0.666667 0.333333 0.254545 0.257576 0.184848 0.30303 0.442424 0.557576 0.160606 0.457576 0.251515 0.130303 0.709091 0.290909 0.671919 34526.26 0.180243 0.346505 0.547112 0.25228 0.094225 0.629179 0.370821 0.231003 0.121581 0.109422 5.750893 9.142857 NMV_0213 2191175 CDS -2 194998 195963 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-11 17:38:18 no Belongs to the IS30 family. 2 vladimir 0.324017 0.3064 0.204969 0.164596 0.511387 0.488613 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.385093 0.170807 0.223602 0.220497 0.39441 0.60559 0.242236 0.453416 0.177019 0.127329 0.630435 0.369565 0.568418 38021.13 -0.898131 0.249221 0.389408 0.196262 0.130841 0.417445 0.582555 0.327103 0.23676 0.090343 10.12397 9.694704 NMV_0215 2191177 CDS -2 196477 199236 2760 validated/Curated no rne ribonuclease E (RNase E) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.26.12 3.1.26.12-RXN$RXN0-6478$RXN0-6485$RXN0-6521$RXN0-6522 PWY0-1479 2018-01-11 17:39:49 no Is responsible for maturing 5S rRNAs from their precursors. It is the major endoribonuclease participating in mRNA turnover in E. coli, which initiates decay of RNAs by cutting them internally near their 5'-end. 2 vladimir 0.266667 0.3304 0.263768 0.13913 0.594203 0.405797 0.25 0.243478 0.407609 0.098913 0.651087 0.348913 0.329348 0.251087 0.202174 0.217391 0.453261 0.546739 0.220652 0.496739 0.181522 0.101087 0.678261 0.321739 0.773105 101970.28 -0.717301 0.300326 0.508161 0.17519 0.063112 0.475517 0.524483 0.326442 0.165397 0.161045 5.972206 10.258977 NMV_0217 2191179 CDS +2 199730 200722 993 validated/Curated no rluC ribosomal large subunit pseudouridine synthase C (rRNA-uridine isomerase C; rRNA pseudouridylate synthase C) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.24 RXN-11838 2018-01-11 17:40:23 no Is responsible for the synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA. 1 vladimir 0.221551 0.2568 0.318228 0.203424 0.575025 0.424975 0.232628 0.277946 0.359517 0.129909 0.637462 0.362538 0.311178 0.18429 0.205438 0.299094 0.389728 0.610272 0.120846 0.308157 0.389728 0.181269 0.697885 0.302115 0.603163 36795.185 -0.329394 0.251515 0.463636 0.254545 0.09697 0.533333 0.466667 0.327273 0.212121 0.115152 9.805779 9.327273 NMV_0218 2191180 CDS +1 200788 201942 1155 validated/Curated no lpxB lipid-A-disaccharide synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 2.4.1.182 LIPIDADISACCHARIDESYNTH-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2020-02-19 14:20:27 no Catalyses the following reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. Is involved in the biosynthesis of the phosphorylated lipid A in the outer membrane. 1 vladimir 0.18961 0.2450 0.342857 0.222511 0.587879 0.412121 0.18961 0.262338 0.394805 0.153247 0.657143 0.342857 0.249351 0.236364 0.18961 0.324675 0.425974 0.574026 0.12987 0.236364 0.444156 0.18961 0.680519 0.319481 0.58985 42368.045 0.089323 0.270833 0.489583 0.273438 0.085938 0.617188 0.382812 0.270833 0.15625 0.114583 9.194496 9.492188 NMV_0219 2191181 CDS +2 201950 202195 246 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 12:47:54 no 3 vladimir 0.414634 0.1179 0.203252 0.264228 0.321138 0.678862 0.402439 0.134146 0.280488 0.182927 0.414634 0.585366 0.414634 0.134146 0.158537 0.292683 0.292683 0.707317 0.426829 0.085366 0.170732 0.317073 0.256098 0.743902 0.446497 9310.47 -0.607407 0.209877 0.395062 0.234568 0.098765 0.481481 0.518519 0.333333 0.222222 0.111111 9.937477 8.753086 NMV_0220 2191182 CDS +3 202197 202607 411 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-22 17:40:17 no 1 vladimir 0.352798 0.1460 0.201946 0.29927 0.347932 0.652068 0.321168 0.153285 0.291971 0.233577 0.445255 0.554745 0.459854 0.116788 0.109489 0.313869 0.226277 0.773723 0.277372 0.167883 0.20438 0.350365 0.372263 0.627737 0.5238 16080.655 -0.418382 0.161765 0.389706 0.235294 0.169118 0.544118 0.455882 0.272059 0.102941 0.169118 4.467445 9.345588 NMV_0221 2191183 CDS -2 202867 203676 810 validated/Curated no dapB 4-hydroxy-tetrahydrodipicolinate reductase (dihydrodipicolinate reductase, DHPR) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 1.17.1.8 DIHYDROPICRED-RXN DAPLYSINESYN-PWY 2018-01-11 17:43:18 no Catalyses the following reaction,which is the second step in the biosynthesis of diaminopimelic acid and lysine: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) <=> 2,3-dihydrodipicolinate + NAD(P)H. 2 vladimir 0.234568 0.3580 0.250617 0.15679 0.608642 0.391358 0.251852 0.2 0.455556 0.092593 0.655556 0.344444 0.274074 0.244444 0.196296 0.285185 0.440741 0.559259 0.177778 0.62963 0.1 0.092593 0.72963 0.27037 0.726021 28266.79 0.027509 0.360595 0.587361 0.237918 0.089219 0.583643 0.416357 0.249071 0.130112 0.118959 5.738075 9.576208 NMV_0222 2191184 CDS -2 203686 204063 378 validated/Curated no bamE outer-membrane protein assembly factor BamE (OmlA) 2a : Function from experimental evidences in other organisms m : membrane component 8 : Outer membrane-associated 2018-01-30 16:28:13 no 21212804 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. 2 vladimir 0.253968 0.3810 0.198413 0.166667 0.579365 0.420635 0.261905 0.301587 0.325397 0.111111 0.626984 0.373016 0.301587 0.230159 0.166667 0.301587 0.396825 0.603175 0.198413 0.611111 0.103175 0.087302 0.714286 0.285714 0.638156 13869.41 -0.1504 0.28 0.504 0.264 0.072 0.536 0.464 0.248 0.136 0.112 8.915398 9.152 NMV_0223 2191185 CDS +3 204282 204716 435 validated/Curated no fur ferric uptake HTH-type transcriptional regulator (ferric uptake regulation protein) 1b : Function from experimental evidences in the studied species r : regulator 2 : Cytoplasmic 3.1.2 : Transcriptional level ; 2020-02-20 14:08:13 no 12081969, 15130126 Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes. 1 vladimir 0.271264 0.2138 0.291954 0.222989 0.505747 0.494253 0.241379 0.2 0.393103 0.165517 0.593103 0.406897 0.427586 0.124138 0.165517 0.282759 0.289655 0.710345 0.144828 0.317241 0.317241 0.22069 0.634483 0.365517 0.716437 16425.945 -0.409722 0.236111 0.416667 0.236111 0.138889 0.506944 0.493056 0.354167 0.173611 0.180556 5.304527 9.875 NMV_0224 2191186 CDS +3 204786 205511 726 validated/Curated no aat leucyl/phenylalanyl-tRNA-protein transferase (L/F-transferase; leucyltransferase; phenylalanyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.6 : Turnover, degradation ; 2.3.2.6 LEUCYLTRANSFERASE-RXN 2018-01-11 17:50:01 no Transfers a Leu or Phe to the amino end of certain proteins to enable their degradation. The N-terminal residue controls the biological half-life of many proteins via the N-end rule pathway. 1 vladimir 0.162534 0.2410 0.348485 0.247934 0.589532 0.410468 0.140496 0.239669 0.400826 0.219008 0.640496 0.359504 0.252066 0.235537 0.231405 0.280992 0.466942 0.533058 0.095041 0.247934 0.413223 0.243802 0.661157 0.338843 0.601481 26832.65 -0.060166 0.302905 0.514523 0.195021 0.149378 0.639004 0.360996 0.248963 0.128631 0.120332 5.818077 10.344398 NMV_0226 2191188 CDS -2 205765 206796 1032 validated/Curated no gap glyceraldehyde 3-phosphate dehydrogenase (GAPDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 1.2.1.12 1.2.1.13-RXN$1.2.1.9-RXN$GAPDHSYNEC-RXN$GAPOXNPHOSPHN-RXN ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2020-04-21 14:06:32 no Catalyses the following reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) <=> 3-phospho-D-glyceroyl phosphate + NADH. 2 vladimir 0.256783 0.3256 0.247093 0.170543 0.572674 0.427326 0.305233 0.18314 0.389535 0.122093 0.572674 0.427326 0.290698 0.229651 0.174419 0.305233 0.40407 0.59593 0.174419 0.563953 0.177326 0.084302 0.741279 0.258721 0.782358 37050.85 -0.027114 0.323615 0.577259 0.244898 0.081633 0.54519 0.45481 0.239067 0.12828 0.110787 6.49099 9.3207 NMV_0227 2191189 CDS -2 206995 207834 840 validated/Curated no rsxB electron transport complex subunit B (RsxB) 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-11 17:54:01 no 12773378 Part of a membrane complex involved in electron transport. 2 vladimir 0.240476 0.3964 0.246429 0.116667 0.642857 0.357143 0.210714 0.278571 0.410714 0.1 0.689286 0.310714 0.303571 0.325 0.196429 0.175 0.521429 0.478571 0.207143 0.585714 0.132143 0.075 0.717857 0.282143 0.717483 30179.42 -0.444086 0.376344 0.548387 0.139785 0.050179 0.55914 0.44086 0.286738 0.164875 0.121864 8.928001 10.688172 NMV_0228 2191190 CDS +2 207983 209959 1977 validated/Curated no putative K(+) efflux antiporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.37 : The Monovalent Cation:Proton Antiporter-2 (CPA2) Family ; 2018-01-11 17:55:29 no Is a transport system that facilitate potassium-efflux, possibly by potassium-proton antiport. 1 vladimir 0.19474 0.2337 0.322205 0.249368 0.555893 0.444107 0.241275 0.194234 0.38695 0.177542 0.581184 0.418816 0.212443 0.210926 0.177542 0.39909 0.388467 0.611533 0.130501 0.295903 0.402124 0.171472 0.698027 0.301973 0.609768 71133.915 0.554255 0.306991 0.493921 0.291793 0.103343 0.664134 0.335866 0.18541 0.095745 0.089666 5.949669 8.990881 NMV_tRNA_7 2194822 tRNA +1 210029 210104 76 validated/Curated no Val tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:47:46 no tRNA Val anticodon TAC. vladimir NMV_tRNA_8 2194823 tRNA +1 210137 210213 77 validated/Curated no Asp tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:47:55 no tRNA Asp anticodon GTC. vladimir NMV_tRNA_9 2194824 tRNA +1 210253 210328 76 validated/Curated no Val tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:48:05 no tRNA Val anticodon TAC. vladimir NMV_tRNA_10 2194825 tRNA +1 210361 210437 77 validated/Curated no Asp tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:48:15 no tRNA Asp anticodon GTC. vladimir NMV_0229 2191191 CDS +2 210650 210811 162 validated/Curated partial truncated modification methylase NlaIII (C-terminal 16% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2020-02-19 14:25:16 no Recognises the double-stranded sequence CATG, causes specific methylation on A-2 on both strands and protects the DNA from cleavage by the NlaIII endonuclease. 1 vladimir 0.333333 0.1543 0.234568 0.277778 0.388889 0.611111 0.296296 0.166667 0.277778 0.259259 0.444444 0.555556 0.444444 0.148148 0.12963 0.277778 0.277778 0.722222 0.259259 0.148148 0.296296 0.296296 0.444444 0.555556 0.514573 6485.13 -0.881132 0.188679 0.339623 0.169811 0.188679 0.415094 0.584906 0.377358 0.226415 0.150943 9.16256 10.037736 NMV_0231 2191193 CDS -1 211025 212479 1455 validated/Curated no sda L-serine dehydratase (L-serine deaminase; SDH; L-SD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.2 : L-serine degradation ; 4.3.1.17 4.3.1.17-RXN$THREDEHYD-RXN ILEUSYN-PWY$SERDEG-PWY 2018-01-29 17:37:54 no Catalyses the following reaction: L-serine <=> pyruvate + NH(3). 2 vladimir 0.218615 0.3240 0.278499 0.178932 0.602453 0.397547 0.222944 0.231602 0.426407 0.119048 0.658009 0.341991 0.261905 0.251082 0.194805 0.292208 0.445887 0.554113 0.170996 0.489177 0.214286 0.125541 0.703463 0.296537 0.64211 49110.55 0.07679 0.338395 0.542299 0.245119 0.071584 0.613883 0.386117 0.232104 0.119306 0.112798 5.936104 9.934924 NMV_0232 2191194 CDS -2 212509 214899 2391 validated/Curated no gyrB DNA gyrase subunit B 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.1.1.1 : DNA bending, supercoiling, inversion ; 5.6.2.2 5.99.1.3-RXN 2020-04-22 16:08:12 no DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes it a better substrate for topoisomerase IV, which is the main enzyme that unlinks newly replicated chromosomes in E.coli. 2 vladimir 0.279799 0.2953 0.25345 0.171476 0.548724 0.451276 0.273526 0.199498 0.397742 0.129235 0.59724 0.40276 0.351317 0.193225 0.17064 0.284818 0.363864 0.636135 0.214555 0.493099 0.19197 0.100376 0.685069 0.314931 0.756935 88226.865 -0.329523 0.280151 0.477387 0.224874 0.090452 0.522613 0.477387 0.30402 0.149497 0.154523 5.449791 9.483668 NMV_0233 2191195 CDS +3 215169 216041 873 validated/Curated no putative Sm-like integral membrane protein 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2018-01-11 17:58:12 no Contains a Sm-like ribonucleoprotein-related core domain that is found as the core structure in Lsm (like-Sm) proteins and bacterial Lsm-related Hfq proteins, and as the middle domain of the mechanosensitive channel protein MscS. 1 vladimir 0.201621 0.2827 0.273556 0.242148 0.556231 0.443769 0.224924 0.255319 0.325228 0.194529 0.580547 0.419453 0.24924 0.231003 0.155015 0.364742 0.386018 0.613982 0.130699 0.361702 0.340426 0.167173 0.702128 0.297872 0.602511 36954.045 0.280183 0.246951 0.472561 0.29878 0.109756 0.615854 0.384146 0.216463 0.131098 0.085366 9.367531 9.387195 NMV_0234 2191196 CDS +3 216129 218165 2037 validated/Curated no prlC oligopeptidase A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.2.3 : Proteins/peptides/glycopeptides ; 3.4.24.70 3.4.24.70-RXN 2018-01-11 17:58:50 no Belongs to the MEROPS peptidase family M3 (clan MA(E)), subfamilies M3A and M3B. Is involved in hydrolysis of oligopeptides, with broad specificity. 2 vladimir 0.261659 0.3328 0.239568 0.16593 0.57241 0.42759 0.223859 0.234168 0.387334 0.154639 0.621502 0.378498 0.338733 0.223859 0.167894 0.269514 0.391753 0.608247 0.222386 0.540501 0.163476 0.073638 0.703976 0.296024 0.741604 76113.055 -0.338496 0.283186 0.471976 0.196165 0.129794 0.551622 0.448378 0.271386 0.128319 0.143068 5.176353 9.644543 NMV_0235 2191197 CDS -1 218840 219406 567 validated/Curated no putative manganese efflux pump MntP 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2017-10-25 23:15:17 no 21908668 1 vladimir 0.155203 0.2116 0.366843 0.266314 0.578483 0.421517 0.227513 0.121693 0.444444 0.206349 0.566138 0.433862 0.126984 0.26455 0.222222 0.386243 0.486772 0.513228 0.111111 0.248677 0.433862 0.206349 0.68254 0.31746 0.601074 19647.515 0.895745 0.393617 0.537234 0.281915 0.111702 0.744681 0.255319 0.143617 0.079787 0.06383 8.284248 8.87234 NMV_0236 2191198 CDS -3 220704 222218 1515 validated/Curated no katA catalase 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 5.6.2 : Detoxification (xenobiotic metabolism) ; 1.11.1.6 CATAL-RXN$RXN66-1 DETOX1-PWY 2018-01-11 17:59:55 no 15312845 Catalyses the following reaction: 2 H(2)O(2) <=> O(2) + 2 H(2)O. Acts to neutralise hydrogen peroxide toxicity. 2 vladimir 0.250825 0.3300 0.248185 0.170957 0.578218 0.421782 0.237624 0.253465 0.352475 0.156436 0.605941 0.394059 0.344554 0.231683 0.192079 0.231683 0.423762 0.576238 0.170297 0.504951 0.2 0.124752 0.704951 0.29505 0.826017 57190.935 -0.656349 0.265873 0.515873 0.146825 0.142857 0.53373 0.46627 0.275794 0.146825 0.128968 6.307381 10.18254 NMV_0237 2191199 fCDS +2 222566 223183 618 validated/Curated partial rpoN truncated RNA polymerase sigma-54 factor (pseudogene part 1) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-27 17:38:19 no 9479056 Contains the sigma-54 factor activator-interacting domain (AID) and core-binding region. 2 vladimir 0.265152 0.3117 0.227273 0.195887 0.538961 0.461039 0.24026 0.318182 0.272727 0.168831 0.590909 0.409091 0.334416 0.253247 0.146104 0.266234 0.399351 0.600649 0.220779 0.363636 0.262987 0.152597 0.626623 0.373377 0.56781 34828.38 -0.450814 0.247557 0.452769 0.218241 0.100977 0.504886 0.495114 0.276873 0.149837 0.127036 6.059364 9.42671 NMV_0237.1 2662678 fCDS +1 223183 223416 234 validated/Curated partial rpoN truncated RNA polymerase sigma-54 factor (pseudogene part 2) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-27 17:38:36 9479056 Contains the sigma-54 DNA-binding domain. vladimir NMV_0238 2191200 fCDS -2 224395 224775 381 validated/Curated pseudo pglA pgtA pilin glycosyl transferase A (pseudogene part 2) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-01-11 18:00:52 no Belongs to the group 1 of glycosyl transferases. Is involved in pilin glycosylation. 1 vladimir 0.270341 0.2231 0.257218 0.249344 0.480315 0.519685 0.299213 0.149606 0.377953 0.173228 0.527559 0.472441 0.314961 0.19685 0.15748 0.330709 0.354331 0.645669 0.19685 0.322835 0.23622 0.244094 0.559055 0.440945 0.586792 14350.155 -0.039683 0.222222 0.468254 0.261905 0.103175 0.579365 0.420635 0.301587 0.15873 0.142857 6.974739 9.936508 NMV_0239 2191201 fCDS -3 224781 225524 744 validated/Curated pseudo pglA pgtA pilin glycosyl transferase A (pseudogene part 1) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-01-11 18:01:04 no Belongs to the group 1 of glycosyl transferases. Is involved in pilin glycosylation. 1 vladimir 0.270548 0.2443 0.222603 0.262557 0.466895 0.533105 0.308219 0.181507 0.311644 0.19863 0.493151 0.506849 0.277397 0.229452 0.133562 0.359589 0.363014 0.636986 0.226027 0.321918 0.222603 0.229452 0.544521 0.455479 0.606293 32293.76 0.170447 0.237113 0.463918 0.281787 0.113402 0.618557 0.381443 0.243986 0.140893 0.103093 9.345634 8.285223 NMV_0240 2191202 CDS -2 225880 227097 1218 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-11 18:01:36 no Belongs to the Major Facilitator Superfamily (MFS) family of transporters, which are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2 vladimir 0.189655 0.3604 0.243021 0.206897 0.603448 0.396552 0.248768 0.236453 0.330049 0.184729 0.566502 0.433498 0.142857 0.293103 0.20197 0.362069 0.495074 0.504926 0.17734 0.551724 0.197044 0.073892 0.748768 0.251232 0.610245 42805.79 0.836296 0.402469 0.533333 0.274074 0.14321 0.718519 0.281481 0.088889 0.066667 0.022222 9.38868 8.501235 NMV_0241 2191203 CDS +2 227525 228478 954 validated/Curated no putative sodium-dependent transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-11 18:02:39 no Belongs to the bile acid:sodium symporter family of proteins. 1 vladimir 0.147335 0.2215 0.350052 0.281087 0.571578 0.428422 0.206897 0.166144 0.416928 0.210031 0.583072 0.416928 0.15047 0.266458 0.184953 0.398119 0.451411 0.548589 0.084639 0.231975 0.448276 0.23511 0.680251 0.319749 0.62234 33240.005 0.899371 0.36478 0.581761 0.301887 0.106918 0.726415 0.273585 0.125786 0.078616 0.04717 8.969017 8.984277 NMV_0242 2191204 CDS -3 228720 229967 1248 validated/Curated no fabF 3-oxoacyl-[acyl-carrier-protein] synthase II (beta-ketoacyl-ACP synthase II; KAS II) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 2.3.1.179 2.3.1.179-RXN$3-OXOACYL-ACP-SYNTH-BASE-RXN$3-OXOACYL-ACP-SYNTH-RXN FASYN-ELONG-PWY$PWY-5966$PWY-5973 2018-02-01 22:09:54 no Catalyses the following reaction with the growing fatty acid chain: (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] <=> (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. 2 vladimir 0.227564 0.3189 0.280449 0.173077 0.599359 0.400641 0.271635 0.141827 0.449519 0.137019 0.591346 0.408654 0.264423 0.247596 0.221154 0.266827 0.46875 0.53125 0.146635 0.567308 0.170673 0.115385 0.737981 0.262019 0.766943 43127.8 -0.001928 0.385542 0.590361 0.216867 0.086747 0.6 0.4 0.233735 0.115663 0.118072 5.448509 9.255422 NMV_0243 2191205 CDS -1 230123 230359 237 validated/Curated no acpP acyl carrier protein (ACP) 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.6.15.4 : Acyl carrier protein ; 2018-01-11 18:03:48 no Is the carrier of the growing fatty acid chain in fatty acid biosynthesis. 2 vladimir 0.324895 0.2447 0.227848 0.202532 0.472574 0.527426 0.253165 0.126582 0.468354 0.151899 0.594937 0.405063 0.443038 0.202532 0.063291 0.291139 0.265823 0.734177 0.278481 0.405063 0.151899 0.164557 0.556962 0.443038 0.89667 8511.015 -0.270513 0.25641 0.525641 0.24359 0.051282 0.487179 0.512821 0.294872 0.064103 0.230769 3.875816 9.512821 NMV_0244 2191206 CDS +2 230591 231598 1008 validated/Curated no pyrD dihydroorotate dehydrogenase [quinone] (dihydroorotate oxidase; DHOdehase; DHODase; DHOD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; 1.3.5.2 RXN0-5244$RXN0-5254$RXN0-6490$RXN0-6491$RXN0-6554 PWY-5686 2020-04-21 14:08:46 no Catalyses the fourth step in the de novo biosynthesis of pyrimidine: (S)-dihydroorotate + a quinone <=> orotate + a quinol. 2 vladimir 0.267857 0.2847 0.247024 0.200397 0.531746 0.468254 0.300595 0.205357 0.366071 0.127976 0.571429 0.428571 0.309524 0.21131 0.172619 0.306548 0.383929 0.616071 0.193452 0.4375 0.202381 0.166667 0.639881 0.360119 0.675364 35806.95 -0.006567 0.292537 0.516418 0.262687 0.077612 0.602985 0.397015 0.232836 0.131343 0.101493 7.890434 8.958209 NMV_0246 2191208 CDS +1 231931 232209 279 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-22 17:41:42 no 25569427 3 vladimir 0.304659 0.1398 0.225806 0.329749 0.365591 0.634409 0.204301 0.139785 0.311828 0.344086 0.451613 0.548387 0.387097 0.172043 0.11828 0.322581 0.290323 0.709677 0.322581 0.107527 0.247312 0.322581 0.354839 0.645161 0.523367 11048.145 -0.195652 0.184783 0.347826 0.23913 0.184783 0.565217 0.434783 0.304348 0.076087 0.228261 4.026421 9.434783 NMV_0247 2191209 CDS +1 232342 232623 282 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-22 17:42:39 no 25569427 1 vladimir 0.283688 0.1631 0.244681 0.308511 0.407801 0.592199 0.234043 0.191489 0.287234 0.287234 0.478723 0.521277 0.414894 0.159574 0.12766 0.297872 0.287234 0.712766 0.202128 0.138298 0.319149 0.340426 0.457447 0.542553 0.57375 11200.15 -0.630108 0.172043 0.397849 0.193548 0.172043 0.473118 0.526882 0.322581 0.139785 0.182796 4.792473 10.182796 NMV_0248 2191210 CDS +2 232676 233149 474 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-22 17:43:01 no 1 vladimir 0.303797 0.1730 0.227848 0.295359 0.400844 0.599156 0.234177 0.170886 0.335443 0.259494 0.506329 0.493671 0.424051 0.177215 0.132911 0.265823 0.310127 0.689873 0.253165 0.170886 0.21519 0.360759 0.386076 0.613924 0.569603 18544.19 -0.615924 0.191083 0.414013 0.210191 0.171975 0.528662 0.471338 0.324841 0.146497 0.178344 4.93058 9.643312 NMV_0249 2191211 CDS +3 233286 233468 183 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-22 17:43:15 no Alternative C-terminus compared to the ortholog in N. meningitidis MC58 and in N. gonorrhoeae. 3 vladimir 0.328042 0.1058 0.312169 0.253968 0.417989 0.582011 0.333333 0.126984 0.396825 0.142857 0.52381 0.47619 0.365079 0.111111 0.190476 0.333333 0.301587 0.698413 0.285714 0.079365 0.349206 0.285714 0.428571 0.571429 0.480649 6989.895 -0.204839 0.241935 0.370968 0.209677 0.129032 0.580645 0.419355 0.33871 0.193548 0.145161 7.036049 9.451613 NMV_0250 2191212 CDS +1 233686 236376 2691 validated/Curated no glnE bifunctional glutamine synthetase adenylyl-L-tyrosine phosphorylase / adenylyl transferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.7.42, 2.7.7.89 GSADENYLATION-RXN$GSDEADENYLATION-RXN 2020-04-21 14:12:08 no Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process of ammonia assimilation. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. 2 vladimir 0.235972 0.3207 0.261613 0.181717 0.582311 0.417689 0.216276 0.273133 0.354515 0.156076 0.627648 0.372352 0.331104 0.220736 0.182832 0.265329 0.403567 0.596433 0.160535 0.468227 0.247492 0.123746 0.715719 0.284281 0.673223 101726.165 -0.402455 0.27567 0.46317 0.206473 0.117188 0.527902 0.472098 0.277902 0.138393 0.139509 5.551262 9.762277 NMV_0252 2191214 CDS -1 236864 237829 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-11 18:12:57 no Belongs to the IS30 family. 2 vladimir 0.322981 0.3075 0.206004 0.163561 0.513458 0.486542 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.381988 0.173913 0.226708 0.217391 0.400621 0.599379 0.242236 0.453416 0.177019 0.127329 0.630435 0.369565 0.567349 38033.11 -0.916822 0.249221 0.392523 0.193146 0.130841 0.417445 0.582555 0.327103 0.23676 0.090343 10.146294 9.76947 NMV_0254 2191216 CDS -1 238094 238786 693 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-22 17:43:42 no 2 vladimir 0.252525 0.3304 0.23088 0.186147 0.561328 0.438672 0.290043 0.324675 0.238095 0.147186 0.562771 0.437229 0.30303 0.238095 0.190476 0.268398 0.428571 0.571429 0.164502 0.428571 0.264069 0.142857 0.692641 0.307359 0.606097 26551.735 -0.38087 0.256522 0.452174 0.234783 0.143478 0.513043 0.486957 0.286957 0.2 0.086957 9.753014 9.382609 NMV_0255 2191217 CDS -2 238894 240087 1194 validated/Curated no putative manganese/divalent cation transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-11 18:14:35 no Belongs to the NRAMP family of transporters. 1 vladimir 0.193467 0.2647 0.284757 0.257119 0.549414 0.450586 0.268844 0.173367 0.384422 0.173367 0.557789 0.442211 0.173367 0.263819 0.163317 0.399497 0.427136 0.572864 0.138191 0.356784 0.306533 0.198492 0.663317 0.336683 0.71687 41216.99 0.913854 0.360202 0.554156 0.319899 0.098237 0.712846 0.287154 0.103275 0.062972 0.040302 9.419655 8.18136 NMV_0256 2191218 CDS -3 240216 240953 738 validated/Curated no pxpA 5-oxoprolinase subunit A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.5.2.9 5-OXOPROLINASE-ATP-HYDROLYSING-RXN PWY-4041 2020-04-21 14:14:40 no 28830929 Catalyses the following reaction: ATP + 5-oxo-L-proline + 2 H2O <=> ADP + phosphate + L-glutamate. 1 vladimir 0.220867 0.2805 0.307588 0.191057 0.588076 0.411924 0.186992 0.223577 0.447154 0.142276 0.670732 0.329268 0.300813 0.235772 0.191057 0.272358 0.426829 0.573171 0.174797 0.382114 0.284553 0.158537 0.666667 0.333333 0.698293 25981.47 -0.022857 0.334694 0.55102 0.228571 0.061224 0.6 0.4 0.240816 0.114286 0.126531 5.122307 9.718367 NMV_0257 2191219 CDS -2 240940 241869 930 validated/Curated no pxpC 5-oxoprolinase subunit C 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.5.2.9 5-OXOPROLINASE-ATP-HYDROLYSING-RXN PWY-4041 2020-04-21 14:15:18 no 28830929 Catalyses the following reaction: ATP + 5-oxo-L-proline + 2 H2O <=> ADP + phosphate + L-glutamate. 1 vladimir 0.230108 0.2645 0.302151 0.203226 0.566667 0.433333 0.23871 0.229032 0.387097 0.145161 0.616129 0.383871 0.274194 0.241935 0.216129 0.267742 0.458065 0.541936 0.177419 0.322581 0.303226 0.196774 0.625806 0.374194 0.649896 33305.81 -0.145307 0.343042 0.517799 0.210356 0.10356 0.601942 0.398058 0.220065 0.132686 0.087379 9.208702 9.686084 NMV_0258 2191220 CDS -3 241866 242513 648 validated/Curated no pxpB 5-oxoprolinase subunit B 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.5.2.9 5-OXOPROLINASE-ATP-HYDROLYSING-RXN PWY-4041 2020-04-21 14:15:53 no 28830929 Catalyses the following reaction: ATP + 5-oxo-L-proline + 2 H2O <=> ADP + phosphate + L-glutamate. 1 vladimir 0.20216 0.2809 0.290123 0.226852 0.570988 0.429012 0.208333 0.231481 0.384259 0.175926 0.615741 0.384259 0.24537 0.273148 0.189815 0.291667 0.462963 0.537037 0.152778 0.337963 0.296296 0.212963 0.634259 0.365741 0.636981 23498.93 -0.019535 0.311628 0.530233 0.227907 0.116279 0.609302 0.390698 0.209302 0.102326 0.106977 5.339668 9.888372 NMV_0259 2191221 CDS +3 242697 244904 2208 validated/Curated no uvrD DNA helicase II 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.4.12 RXN0-2621 2018-01-22 16:47:36 no A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. 2 vladimir 0.260417 0.3456 0.227355 0.166667 0.572917 0.427083 0.255435 0.256793 0.353261 0.134511 0.610054 0.389946 0.327446 0.211957 0.17663 0.283967 0.388587 0.611413 0.19837 0.567935 0.152174 0.081522 0.720109 0.279891 0.756806 82097.19 -0.295918 0.280272 0.469388 0.216327 0.10068 0.537415 0.462585 0.258503 0.133333 0.12517 6.010124 9.610884 NMV_0260 2191222 CDS +2 245261 245800 540 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:12:23 no 1 vladimir 0.275926 0.1963 0.272222 0.255556 0.468519 0.531482 0.205556 0.15 0.4 0.244444 0.55 0.45 0.366667 0.183333 0.172222 0.277778 0.355556 0.644444 0.255556 0.255556 0.244444 0.244444 0.5 0.5 0.681003 20368.84 -0.349162 0.256983 0.469274 0.184358 0.150838 0.541899 0.458101 0.27933 0.078212 0.201117 4.133553 9.636872 NMV_0261 2191223 CDS -1 245990 246205 216 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-22 17:46:01 no 25569427 3 vladimir 0.375 0.1157 0.189815 0.319444 0.305556 0.694444 0.305556 0.125 0.347222 0.222222 0.472222 0.527778 0.375 0.138889 0.111111 0.375 0.25 0.75 0.444444 0.083333 0.111111 0.361111 0.194444 0.805556 0.497447 8089.97 0.132394 0.211268 0.380282 0.338028 0.056338 0.535211 0.464789 0.267606 0.070423 0.197183 4.073418 9.394366 NMV_0263 2191225 CDS -1 246329 246688 360 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:57:24 no 25569427 3 vladimir 0.363889 0.1250 0.15 0.361111 0.275 0.725 0.325 0.108333 0.216667 0.35 0.325 0.675 0.391667 0.15 0.141667 0.316667 0.291667 0.708333 0.375 0.116667 0.091667 0.416667 0.208333 0.791667 0.544219 14199.61 -0.294958 0.201681 0.378151 0.226891 0.184874 0.495798 0.504202 0.302521 0.12605 0.176471 4.664833 8.260504 NMV_0264 2191226 CDS +3 246741 247118 378 validated/Curated partial truncated IS1016 group transposase (missing an internal 40% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-02-13 13:10:06 no 3 vladimir 0.346561 0.1693 0.198413 0.285714 0.367725 0.632275 0.357143 0.198413 0.230159 0.214286 0.428571 0.571429 0.380952 0.126984 0.214286 0.277778 0.34127 0.65873 0.301587 0.18254 0.150794 0.365079 0.333333 0.666667 0.493659 14836.36 -0.5824 0.232 0.4 0.208 0.168 0.44 0.56 0.312 0.208 0.104 9.611916 9.088 NMV_0265 2191227 CDS +3 247317 247937 621 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-02-13 13:10:22 no 1 vladimir 0.186795 0.2367 0.231884 0.344605 0.468599 0.531401 0.256039 0.173913 0.289855 0.280193 0.463768 0.536232 0.15942 0.231884 0.188406 0.42029 0.42029 0.57971 0.144928 0.304348 0.217391 0.333333 0.521739 0.478261 0.5747 22297.525 0.948544 0.354369 0.485437 0.305825 0.15534 0.694175 0.305825 0.116505 0.072816 0.043689 8.43325 8.033981 NMV_0266 2191228 CDS +1 247927 249411 1485 validated/Curated no putative polyamine aminopropyltransferase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2.5.1.16 RXN-12514$SPERMIDINESYN-RXN BSUBPOLYAMSYN-PWY$PWY-6834 2018-01-27 17:58:08 no Might catalyse the following reaction: S-adenosyl 3-(methylthio)propylamine + putrescine <=> 5'-S-methyl-5'-thioadenosine + spermidine. 1 vladimir 0.212795 0.2377 0.251178 0.298317 0.488889 0.511111 0.254545 0.20404 0.323232 0.218182 0.527273 0.472727 0.234343 0.216162 0.181818 0.367677 0.39798 0.60202 0.149495 0.292929 0.248485 0.309091 0.541414 0.458586 0.632301 54759.575 0.371053 0.287449 0.508097 0.281377 0.137652 0.625506 0.374494 0.180162 0.107287 0.072874 8.830269 8.880567 NMV_0267 2191229 CDS +3 249873 250229 357 validated/Curated no nuoA NADH-quinone oxidoreductase chain A (NADH dehydrogenase I, chain A; NDH-1, chain A) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:35:01 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.179272 0.2409 0.277311 0.302521 0.518207 0.481793 0.168067 0.151261 0.394958 0.285714 0.546218 0.453782 0.235294 0.168067 0.142857 0.453782 0.310924 0.689076 0.134454 0.403361 0.294118 0.168067 0.697479 0.302521 0.694624 13583.705 0.9 0.220339 0.415254 0.305085 0.220339 0.771186 0.228814 0.186441 0.084746 0.101695 5.02372 9.042373 NMV_0268 2191230 CDS +2 250220 250702 483 validated/Curated no nuoB NADH-quinone oxidoreductase chain B (NADH dehydrogenase I, chain B; NDH-1, chain B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:34:39 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 2 vladimir 0.190476 0.2754 0.289855 0.244306 0.565217 0.434783 0.223602 0.229814 0.354037 0.192547 0.583851 0.416149 0.236025 0.254658 0.21118 0.298137 0.465838 0.534161 0.111801 0.341615 0.304348 0.242236 0.645963 0.354037 0.747428 17628.845 0.07125 0.325 0.5375 0.225 0.10625 0.6375 0.3625 0.2 0.11875 0.08125 8.952888 10.26875 NMV_0269 2191231 CDS +2 250715 251308 594 validated/Curated no nuoC NADH-quinone oxidoreductase chain C (NADH dehydrogenase I, chain C; NDH-1, chain C) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 RXN0-5244$RXN0-5248$RXN0-5330 2018-01-29 18:34:19 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.249158 0.2609 0.250842 0.239057 0.511784 0.488215 0.217172 0.227273 0.373737 0.181818 0.60101 0.39899 0.363636 0.141414 0.176768 0.318182 0.318182 0.681818 0.166667 0.414141 0.20202 0.217172 0.616162 0.383838 0.761078 22993.09 -0.323858 0.192893 0.472081 0.253807 0.142132 0.532995 0.467005 0.284264 0.121827 0.162437 4.758186 10.385787 NMV_0270 2191232 CDS +3 251298 252554 1257 validated/Curated no nuoD NADH-quinone oxidoreductase chain D (NADH dehydrogenase I, chain D; NDH-1, chain D) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 RXN0-5244$RXN0-5248$RXN0-5330 2018-01-29 18:33:59 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 2 vladimir 0.246619 0.2999 0.249006 0.204455 0.548926 0.451074 0.25537 0.229117 0.360382 0.155131 0.589499 0.410501 0.322196 0.193317 0.176611 0.307876 0.369928 0.630072 0.162291 0.477327 0.210024 0.150358 0.687351 0.312649 0.75829 47577.135 -0.27177 0.244019 0.454545 0.212919 0.126794 0.574163 0.425837 0.289474 0.157895 0.131579 6.574944 10.327751 NMV_0271 2191233 CDS +2 252554 253027 474 validated/Curated no nuoE NADH-quinone oxidoreductase chain E (NADH dehydrogenase I, chain E; NDH-1, chain E) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:33:00 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.259494 0.2975 0.244726 0.198312 0.542194 0.457806 0.278481 0.177215 0.379747 0.164557 0.556962 0.443038 0.316456 0.253165 0.164557 0.265823 0.417722 0.582278 0.183544 0.462025 0.189873 0.164557 0.651899 0.348101 0.729147 17134.1 -0.076433 0.343949 0.496815 0.191083 0.089172 0.605096 0.394904 0.229299 0.095541 0.133758 4.750816 10.11465 NMV_0272 2191234 CDS +1 253417 254712 1296 validated/Curated no nuoF NADH-quinone oxidoreductase chain F (NADH dehydrogenase I, chain F; NDH-1, chain F) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:32:39 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.233796 0.2708 0.260802 0.234568 0.531636 0.468364 0.243056 0.171296 0.375 0.210648 0.546296 0.453704 0.293981 0.222222 0.210648 0.273148 0.43287 0.56713 0.164352 0.418981 0.196759 0.219907 0.615741 0.384259 0.777685 47143.95 -0.1942 0.324826 0.512761 0.178654 0.12993 0.605568 0.394432 0.243619 0.12297 0.12065 5.692894 9.730858 NMV_0273 2191235 CDS +3 254877 255293 417 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2015-11-17 11:36:19 no 1 vladimir 0.269231 0.1763 0.278846 0.275641 0.455128 0.544872 0.173077 0.221154 0.336538 0.269231 0.557692 0.442308 0.413462 0.211538 0.115385 0.259615 0.326923 0.673077 0.221154 0.096154 0.384615 0.298077 0.480769 0.519231 0.518156 12050.11 -0.365049 0.242718 0.407767 0.203883 0.165049 0.553398 0.446602 0.23301 0.097087 0.135922 4.709908 10.194175 NMV_0274 2191236 CDS +2 255389 257650 2262 validated/Curated no nuoG NADH-quinone oxidoreductase chain G (NADH dehydrogenase I, chain G; NDH-1, chain G) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:32:12 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 2 vladimir 0.2458 0.2692 0.279841 0.205128 0.549072 0.450928 0.234748 0.214854 0.400531 0.149867 0.615385 0.384615 0.30504 0.241379 0.179045 0.274536 0.420424 0.579576 0.197613 0.351459 0.259947 0.190981 0.611406 0.388594 0.772025 81593.6 -0.156042 0.318725 0.539177 0.231076 0.075697 0.549801 0.450199 0.25498 0.128818 0.126162 5.659462 9.532537 NMV_0275 2191237 CDS +1 257653 258729 1077 validated/Curated no nuoH NADH-quinone oxidoreductase chain H (NADH dehydrogenase I, chain H; NDH-1, chain H) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:31:37 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 2 vladimir 0.184773 0.2748 0.265552 0.274838 0.54039 0.45961 0.247911 0.18663 0.311978 0.253482 0.498607 0.501393 0.181058 0.24234 0.155989 0.420613 0.398329 0.601671 0.125348 0.395543 0.328691 0.150418 0.724234 0.275766 0.781659 39925.955 0.863687 0.284916 0.46648 0.304469 0.167598 0.731844 0.268156 0.108939 0.061453 0.047486 8.828133 8.522346 NMV_0276 2191238 CDS +2 258779 259117 339 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2018-01-30 19:01:22 no 1 vladimir 0.280236 0.2094 0.265487 0.244838 0.474926 0.525074 0.265487 0.132743 0.389381 0.212389 0.522124 0.477876 0.345133 0.176991 0.20354 0.274336 0.380531 0.619469 0.230089 0.318584 0.20354 0.247788 0.522124 0.477876 0.62586 12529.665 -0.25 0.303571 0.508929 0.214286 0.107143 0.517857 0.482143 0.267857 0.142857 0.125 6.918022 9.651786 NMV_0277 2191239 CDS +1 259177 259656 480 validated/Curated no nuoI NADH-quinone oxidoreductase chain I (NADH dehydrogenase I, chain I; NDH-1, chain I) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:31:15 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.275 0.2688 0.25625 0.2 0.525 0.475 0.26875 0.18125 0.35 0.2 0.53125 0.46875 0.35 0.2125 0.1875 0.25 0.4 0.6 0.20625 0.4125 0.23125 0.15 0.64375 0.35625 0.751932 18137.33 -0.415723 0.283019 0.440252 0.18239 0.113208 0.540881 0.459119 0.345912 0.188679 0.157233 7.694969 10.352201 NMV_0278 2191240 CDS +3 259668 260339 672 validated/Curated no nuoJ NADH-quinone oxidoreductase chain J (NADH dehydrogenase I, chain J; NDH-1, chain J) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:30:49 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 2 vladimir 0.197917 0.2485 0.294643 0.258929 0.543155 0.456845 0.241071 0.205357 0.401786 0.151786 0.607143 0.392857 0.227679 0.21875 0.133929 0.419643 0.352679 0.647321 0.125 0.321429 0.348214 0.205357 0.669643 0.330357 0.768215 24519.3 0.657848 0.255605 0.497758 0.318386 0.098655 0.681614 0.318386 0.201794 0.107623 0.09417 6.477425 9.479821 NMV_0279 2191241 CDS +2 260336 260641 306 validated/Curated no nuoK NADH-quinone oxidoreductase chain K (NADH dehydrogenase I, chain K; NDH-1, chain K) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:30:28 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.20915 0.2386 0.25817 0.294118 0.496732 0.503268 0.284314 0.176471 0.333333 0.205882 0.509804 0.490196 0.215686 0.186275 0.107843 0.490196 0.294118 0.705882 0.127451 0.352941 0.333333 0.186275 0.686275 0.313726 0.726253 11077.82 1.073267 0.267327 0.455446 0.356436 0.118812 0.693069 0.306931 0.128713 0.069307 0.059406 6.043983 8.732673 NMV_0280 2191242 CDS +2 260705 261250 546 validated/Curated no putative protein adenylyltransferase Fic 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.1 : Cell division ; 2020-04-21 14:17:13 no 23738009 Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Fic (filamentation induced by cAMP). 1 vladimir 0.303819 0.2135 0.248264 0.234375 0.461806 0.538194 0.317708 0.192708 0.317708 0.171875 0.510417 0.489583 0.390625 0.130208 0.177083 0.302083 0.307292 0.692708 0.203125 0.317708 0.25 0.229167 0.567708 0.432292 0.683156 22189.45 -0.51623 0.204188 0.397906 0.225131 0.120419 0.507853 0.492147 0.303665 0.151832 0.151832 5.737648 9.612565 NMV_0281 2191243 CDS +2 261377 261715 339 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-17 11:40:26 no 3 vladimir 0.315789 0.1374 0.260234 0.28655 0.397661 0.602339 0.27193 0.175439 0.315789 0.236842 0.491228 0.508772 0.385965 0.157895 0.149123 0.307018 0.307018 0.692982 0.289474 0.078947 0.315789 0.315789 0.394737 0.605263 0.539537 12983.56 -0.361062 0.230088 0.380531 0.212389 0.123894 0.539823 0.460177 0.274336 0.150442 0.123894 8.022667 9.283186 NMV_0282 2191244 CDS +2 261764 263788 2025 validated/Curated no nuoL NADH-quinone oxidoreductase chain L (NADH dehydrogenase I, chain L; NDH-1, chain L) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:29:02 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.191605 0.2672 0.259259 0.281975 0.52642 0.47358 0.253333 0.179259 0.336296 0.231111 0.515556 0.484444 0.222222 0.22963 0.148148 0.4 0.377778 0.622222 0.099259 0.392593 0.293333 0.214815 0.685926 0.314074 0.749321 74189.355 0.647626 0.307122 0.491098 0.267062 0.176558 0.689911 0.310089 0.146884 0.090504 0.05638 7.497047 8.867953 NMV_0283 2191245 CDS +3 263877 265373 1497 validated/Curated no nuoM NADH-quinone oxidoreductase chain M (NADH dehydrogenase I, chain M; NDH-1, chain M) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:28:44 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.175685 0.2218 0.297261 0.305277 0.519038 0.480962 0.242485 0.188377 0.350701 0.218437 0.539078 0.460922 0.196393 0.218437 0.144289 0.440882 0.362725 0.637275 0.088176 0.258517 0.396794 0.256513 0.655311 0.344689 0.726525 54643.265 0.940361 0.283133 0.473896 0.305221 0.156627 0.748996 0.251004 0.12249 0.074297 0.048193 8.62455 8.909639 NMV_0284 2191246 CDS +3 265383 266828 1446 validated/Curated no nuoN NADH-quinone oxidoreductase chain N (NADH dehydrogenase I, chain N; NDH-1, chain N) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.6.5.11 NADH-DEHYDROG-A-RXN$RXN0-5244$RXN0-5248$RXN0-5254$RXN0-5267$RXN0-5388 PWY-3781 2018-01-29 18:28:23 no One of 14 subunits (A to N) of the NADH-quinone oxidoreductase complex I, which catalyses the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor. 1 vladimir 0.162517 0.2642 0.289765 0.283541 0.553942 0.446058 0.19917 0.178423 0.379668 0.242739 0.558091 0.441909 0.190871 0.251037 0.147303 0.410788 0.39834 0.60166 0.09751 0.363071 0.342324 0.197095 0.705394 0.294606 0.711035 52046.63 0.884823 0.328482 0.509356 0.299376 0.143451 0.72973 0.27027 0.126819 0.070686 0.056133 6.775856 8.858628 NMV_0285 2191247 CDS +3 266940 267239 300 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2020-04-23 18:24:02 no Belongs to the UCP019883 family of proteins, which are not functionally characterised. 1 vladimir 0.166667 0.3000 0.256667 0.276667 0.556667 0.443333 0.2 0.25 0.29 0.26 0.54 0.46 0.21 0.24 0.16 0.39 0.4 0.6 0.09 0.41 0.32 0.18 0.73 0.27 0.583742 11452.2 0.694949 0.282828 0.40404 0.272727 0.232323 0.707071 0.292929 0.181818 0.131313 0.050505 9.147285 9.333333 NMV_0286 2191248 CDS -3 267348 268244 897 validated/Curated no ispA farnesyl diphosphate synthase (geranyltranstransferase; FPP synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 2.5.1.10 FPPSYN-RXN$GPPSYN-RXN PWY-5122$PWY-5123 2018-01-17 14:41:02 no Catalyses the following reaction: geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate. 2 vladimir 0.239688 0.2542 0.313266 0.192865 0.567447 0.432553 0.19398 0.234114 0.424749 0.147157 0.658863 0.341137 0.311037 0.267559 0.137124 0.284281 0.404682 0.595318 0.214047 0.26087 0.377926 0.147157 0.638796 0.361204 0.681448 32098.505 -0.039262 0.318792 0.513423 0.228188 0.07047 0.587248 0.412752 0.258389 0.120805 0.137584 5.049995 9.536913 NMV_0287 2191249 CDS -2 268228 268452 225 validated/Curated no xseB exodeoxyribonuclease VII small subunit (exonuclease VII small subunit) 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 3.1.11.6 3.1.11.6-RXN 2018-01-17 14:43:18 no 15661009 Exonuclease VII is composed of two non-identical subunits: one large subunit and 4 small ones. It catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. 1 vladimir 0.288889 0.2356 0.288889 0.186667 0.524444 0.475556 0.2 0.226667 0.373333 0.2 0.6 0.4 0.44 0.213333 0.093333 0.253333 0.306667 0.693333 0.226667 0.266667 0.4 0.106667 0.666667 0.333333 0.579515 8345.065 -0.682432 0.243243 0.405405 0.202703 0.040541 0.459459 0.540541 0.310811 0.108108 0.202703 4.420555 9.527027 NMNmiscRNA0162 54919395 misc_RNA +1 268519 268643 125 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:34:02 28334889 Function unknown. vladimir NMV_0288 2191250 CDS -3 268716 269639 924 validated/Curated no rsgA small ribosomal subunit biogenesis GTPase RsgA (EngC) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; 3.6.1.- RXN0-5462 2018-01-30 15:15:40 no One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. 2 vladimir 0.229437 0.3885 0.22619 0.155844 0.614719 0.385281 0.243506 0.298701 0.331169 0.126623 0.62987 0.37013 0.275974 0.279221 0.198052 0.246753 0.477273 0.522727 0.168831 0.587662 0.149351 0.094156 0.737013 0.262987 0.71076 33529.85 -0.284691 0.34202 0.52443 0.201954 0.094463 0.540717 0.459283 0.237785 0.136808 0.100977 8.35453 9.488599 NMV_0289 2191251 CDS -2 269644 271500 1857 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-02-13 13:17:31 no 2 vladimir 0.206785 0.3199 0.278945 0.1944 0.598815 0.401185 0.23748 0.235864 0.369952 0.156704 0.605816 0.394184 0.243942 0.252019 0.182553 0.321486 0.434572 0.565428 0.138934 0.471729 0.28433 0.105008 0.756058 0.243942 0.680814 68000.015 0.129126 0.322006 0.487055 0.2411 0.108414 0.598706 0.401294 0.220065 0.121359 0.098706 7.94117 9.194175 NMV_0290 2191252 CDS -2 271663 272247 585 validated/Curated no ruvA Holliday junction ATP-dependent DNA helicase RuvA 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.4.12 3.1.22.4-RXN 2018-01-22 16:49:53 no Forms a complex with RuvB. This complex is a helicase that mediates the Holliday junction migration by localised denaturation and re-annealing. 1 vladimir 0.241026 0.2684 0.305983 0.184615 0.574359 0.425641 0.251282 0.210256 0.441026 0.097436 0.651282 0.348718 0.276923 0.246154 0.164103 0.312821 0.410256 0.589744 0.194872 0.348718 0.312821 0.14359 0.661538 0.338462 0.669866 20687.065 0.068041 0.324742 0.520619 0.262887 0.056701 0.582474 0.417526 0.262887 0.128866 0.134021 5.546028 9.164948 NMV_0291 2191253 CDS -2 272329 272655 327 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-02-13 15:24:57 no 2 vladimir 0.272171 0.3578 0.232416 0.137615 0.590214 0.409786 0.229358 0.266055 0.422018 0.082569 0.688073 0.311927 0.385321 0.220183 0.174312 0.220183 0.394495 0.605505 0.201835 0.587156 0.100917 0.110092 0.688073 0.311927 0.767991 11817.645 -0.637963 0.296296 0.527778 0.203704 0.111111 0.472222 0.527778 0.37037 0.222222 0.148148 6.818367 9.388889 NMV_0292 2191254 CDS -3 272709 273428 720 validated/Curated no rlpA endolytic peptidoglycan transglycosylase RlpA 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 4.2.2.- 2018-02-01 17:50:50 no Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. 2 vladimir 0.273611 0.3361 0.229167 0.161111 0.565278 0.434722 0.279167 0.2 0.366667 0.154167 0.566667 0.433333 0.3125 0.3 0.1625 0.225 0.4625 0.5375 0.229167 0.508333 0.158333 0.104167 0.666667 0.333333 0.71378 25930.27 -0.405021 0.364017 0.548117 0.167364 0.112971 0.514644 0.485356 0.238494 0.16318 0.075314 9.991203 9.372385 NMV_0293 2191255 CDS -3 273558 274022 465 validated/Curated no trmL tRNA (cytidine(34)-2'-O)-methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.207 RXN-11860$RXN-11865 2020-02-19 14:36:17 no Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyses methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. 2 vladimir 0.221505 0.3355 0.255914 0.187097 0.591398 0.408602 0.258065 0.270968 0.329032 0.141935 0.6 0.4 0.258065 0.251613 0.193548 0.296774 0.445161 0.554839 0.148387 0.483871 0.245161 0.122581 0.729032 0.270968 0.639317 16844.815 -0.05 0.305195 0.519481 0.220779 0.103896 0.603896 0.396104 0.220779 0.123377 0.097403 7.958687 9.324675 NMV_0294 2191256 CDS -2 274087 274647 561 validated/Curated no putative GntX-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-22 17:50:22 no Belongs to the ComF/GntX family. Could be involved in gluconate metabolism or in transformation (competence for DNA uptake). 2 vladimir 0.22314 0.3030 0.282369 0.19146 0.585399 0.414601 0.243802 0.297521 0.280992 0.177686 0.578512 0.421488 0.252066 0.231405 0.252066 0.264463 0.483471 0.516529 0.173554 0.380165 0.31405 0.132231 0.694215 0.305785 0.620874 26989.37 -0.261411 0.302905 0.522822 0.195021 0.095436 0.568465 0.431535 0.257261 0.165975 0.091286 9.209343 10.033195 NMV_0295 2191257 CDS +2 274718 275554 837 validated/Curated no bioH pimeloyl-[acyl-carrier protein] methyl ester esterase (biotin synthesis protein BioH) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 3.1.1.85 CARBOXYLESTERASE-RXN$RXN-11483 PWY-6519 2020-04-20 17:47:07 no Catalyses the following reaction: pimeloyl-[acyl-carrier protein] methyl ester + H2O <=> pimeloyl-[acyl-carrier protein] + methanol. Required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. 1 vladimir 0.182796 0.2876 0.318548 0.211022 0.606183 0.393817 0.16129 0.266129 0.427419 0.145161 0.693548 0.306452 0.258065 0.28629 0.16129 0.294355 0.447581 0.552419 0.129032 0.310484 0.366935 0.193548 0.677419 0.322581 0.598488 26690.76 0.121053 0.307692 0.530364 0.234818 0.121457 0.647773 0.352227 0.263158 0.1417 0.121457 5.978081 9.283401 NMV_0296 2191258 CDS +3 275556 276344 789 validated/Curated no putative methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 17:59:28 no Belongs to the S-adenosyl-L-methionine-dependent family of methyltransferases. 1 vladimir 0.21673 0.2471 0.319392 0.21673 0.56654 0.43346 0.212928 0.243346 0.368821 0.174905 0.612167 0.387833 0.30038 0.224335 0.197719 0.277567 0.422053 0.577947 0.136882 0.273764 0.391635 0.197719 0.665399 0.334601 0.618426 29444.565 -0.230153 0.290076 0.496183 0.194656 0.129771 0.572519 0.427481 0.270992 0.145038 0.125954 6.265083 9.755725 NMV_0298 2191260 CDS +3 276798 277094 297 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-07-21 16:14:01 no 3 vladimir 0.346801 0.0774 0.148148 0.427609 0.225589 0.774411 0.393939 0.040404 0.161616 0.40404 0.20202 0.79798 0.313131 0.151515 0.121212 0.414141 0.272727 0.727273 0.333333 0.040404 0.161616 0.464646 0.20202 0.79798 0.473977 11814.735 0.461224 0.214286 0.346939 0.27551 0.22449 0.632653 0.367347 0.183673 0.132653 0.05102 9.516747 8.346939 NMV_0299 2191261 CDS +1 277132 277557 426 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 15:28:49 no 1 vladimir 0.288732 0.2113 0.274648 0.225352 0.485915 0.514084 0.295775 0.190141 0.295775 0.21831 0.485915 0.514085 0.338028 0.211268 0.211268 0.239437 0.422535 0.577465 0.232394 0.232394 0.316901 0.21831 0.549296 0.450704 0.520019 16288.03 -0.564539 0.297872 0.460993 0.170213 0.148936 0.510638 0.489362 0.276596 0.177305 0.099291 9.681343 9.085106 NMV_0300 2191262 CDS -1 277700 280000 2301 validated/Curated no recQ ATP-dependent DNA helicase RecQ 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.4.12 RXN0-4261 2018-01-17 14:54:22 no Involved in the RecF recombination pathway; gene expression is under the regulation of the SOS system. It is a DNA helicase. 2 vladimir 0.244676 0.2977 0.27249 0.185137 0.570187 0.429813 0.217731 0.268579 0.376793 0.136897 0.645372 0.354628 0.319426 0.196871 0.209909 0.273794 0.40678 0.59322 0.196871 0.42764 0.230769 0.14472 0.658409 0.341591 0.679219 86180.245 -0.316057 0.275457 0.464752 0.223238 0.100522 0.545692 0.454308 0.293734 0.157963 0.13577 6.559669 10.009138 NMV_0301 2191263 CDS -3 280065 280847 783 validated/Curated no trpC indole-3-glycerol phosphate synthase (IGPS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 4.1.1.48 IGPSYN-RXN TRPSYN-PWY 2018-01-17 14:55:07 no Catalyses the fourth step in the biosynthesis of tryptophan: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate <=> C(1)-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O. 1 vladimir 0.241379 0.3078 0.273308 0.177522 0.581098 0.418902 0.226054 0.249042 0.40613 0.118774 0.655172 0.344828 0.302682 0.249042 0.153257 0.295019 0.402299 0.597701 0.195402 0.425287 0.260536 0.118774 0.685824 0.314176 0.685293 28778.925 -0.082308 0.292308 0.473077 0.242308 0.088462 0.557692 0.442308 0.288462 0.142308 0.146154 5.50576 9.584615 NMV_0302 2191264 CDS -3 280896 281852 957 validated/Curated no putative hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-17 14:55:40 no Member of a group of proteins predicted to be hydrolases with an alpha/beta hydrolase fold. 2 vladimir 0.195402 0.3511 0.266458 0.187043 0.617555 0.382445 0.191223 0.291536 0.354232 0.163009 0.645768 0.354232 0.244514 0.285266 0.203762 0.266458 0.489028 0.510972 0.15047 0.476489 0.241379 0.131661 0.717868 0.282132 0.666736 34756.285 -0.113522 0.339623 0.544025 0.198113 0.144654 0.597484 0.402516 0.232704 0.141509 0.091195 8.930565 9.424528 NMV_0303 2191265 CDS -3 281985 283523 1539 validated/Curated no putative lipid II flippase MurJ 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 1.6.7 : Peptidoglycan (murein) ; 2018-01-17 14:56:22 no Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. 1 vladimir 0.17024 0.2625 0.2859 0.281352 0.548408 0.451592 0.214425 0.226121 0.327485 0.231969 0.553606 0.446394 0.175439 0.261209 0.153996 0.409357 0.415205 0.584795 0.120858 0.300195 0.376218 0.202729 0.676413 0.323587 0.636949 55682.345 0.804297 0.316406 0.478516 0.289062 0.144531 0.716797 0.283203 0.134766 0.09375 0.041016 9.885353 8.361328 NMV_0304 2191266 CDS +3 283980 284678 699 validated/Curated no dsbA1 thiol:disulfide interchange lipoprotein DsbA1 1a : Function from experimental evidences in the studied strain e : enzyme 11 : Membrane 2008-02-13 15:30:22 no 15105427 2 vladimir 0.261803 0.3119 0.248927 0.177396 0.560801 0.439199 0.236051 0.223176 0.420601 0.120172 0.643777 0.356223 0.347639 0.266094 0.124464 0.261803 0.390558 0.609442 0.201717 0.446352 0.201717 0.150215 0.648069 0.351931 0.715174 25272.805 -0.178017 0.314655 0.521552 0.193966 0.103448 0.560345 0.439655 0.267241 0.133621 0.133621 5.518364 9.189655 NMV_0305 2191267 CDS -1 284735 285739 1005 validated/Curated no amgK N-acetylmuramate/N-acetylglucosamine kinase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 2.7.1.221 2020-02-19 19:41:01 no 23831760 Catalyses the following reactions: ATP + N-acetyl-D-glucosamine <=> ADP + N-acetyl-alpha-D-glucosamine 1-phosphate; ATP + N-acetylmuramate <= >ADP + N-acetyl-alpha-muramate 1-phosphate. Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. 1 vladimir 0.220896 0.2577 0.282587 0.238806 0.540298 0.459701 0.173134 0.256716 0.355224 0.214925 0.61194 0.38806 0.316418 0.185075 0.164179 0.334328 0.349254 0.650746 0.173134 0.331343 0.328358 0.167164 0.659701 0.340299 0.670283 39131.705 -0.18982 0.197605 0.419162 0.242515 0.146707 0.580838 0.419162 0.284431 0.134731 0.149701 5.20359 9.853293 NMV_0306 2191268 CDS +2 285809 288217 2409 validated/Curated no LOS assembly protein LptD (Imp) 2a : Function from experimental evidences in other organisms m : membrane component 11 : Membrane 1.6.3 : Lipopolysaccharide ; 2020-04-22 17:09:18 no Together with LptE, is involved in the assembly of lipooligosaccharide (LOS) at the surface of the outer membrane 2 vladimir 0.232762 0.3246 0.268336 0.174352 0.592885 0.407115 0.245059 0.234519 0.354414 0.166008 0.588933 0.411067 0.321476 0.210804 0.247694 0.220026 0.458498 0.541502 0.131752 0.528327 0.202899 0.137022 0.731225 0.268775 0.658035 84020.955 -0.574274 0.328496 0.550132 0.171504 0.127968 0.521108 0.478892 0.238786 0.133245 0.105541 8.984825 9.663588 NMV_0307 2191269 CDS +1 288322 289383 1062 validated/Curated no putative chaperone SurA 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-22 17:17:23 no Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognises specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. 2 vladimir 0.267606 0.3268 0.257277 0.148357 0.584038 0.415962 0.242254 0.239437 0.433803 0.084507 0.673239 0.326761 0.326761 0.28169 0.152113 0.239437 0.433803 0.566197 0.233803 0.459155 0.185915 0.121127 0.64507 0.35493 0.747466 37950.675 -0.267797 0.333333 0.522599 0.200565 0.056497 0.545198 0.454802 0.257062 0.152542 0.10452 9.733147 9.367232 NMV_0308 2191270 CDS -1 290405 292285 1881 validated/Curated no putative ribonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.-.- 3.1.13.1-RXN$3.1.26.12-RXN$3.1.26.3-RXN$3.1.26.5-RXN$3.1.27.5-RXN$RXN0-6478$RXN0-6479$RXN0-6480$RXN0-6485$RXN0-6521$RXN0-6522$RXN0-6523$RXN0-6524 PWY0-1479 2018-03-22 17:51:39 no 2 vladimir 0.266348 0.3062 0.248272 0.17916 0.554492 0.445508 0.261563 0.204147 0.379585 0.154705 0.583732 0.416268 0.349282 0.269537 0.121212 0.259968 0.39075 0.60925 0.188198 0.444976 0.244019 0.122807 0.688995 0.311005 0.754948 69377.935 -0.283067 0.298722 0.490415 0.186901 0.115016 0.552716 0.447284 0.261981 0.116613 0.145367 4.869484 9.269968 NMV_0309 2191271 CDS +1 292441 293073 633 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-01-27 18:03:22 no Similar to putative cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG. 1 vladimir 0.183254 0.2433 0.344392 0.229068 0.587678 0.412322 0.175355 0.21327 0.407583 0.203791 0.620853 0.379147 0.260664 0.270142 0.180095 0.2891 0.450237 0.549763 0.113744 0.246445 0.445498 0.194313 0.691943 0.308057 0.57574 22742.965 -0.004286 0.32381 0.528571 0.219048 0.109524 0.609524 0.390476 0.219048 0.109524 0.109524 5.673882 9.471429 NMV_0310 2191272 CDS +3 293145 294515 1371 validated/Curated no purB adenylosuccinate lyase (adenylosuccinase; ASL) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 4.3.2.2 AICARSYN-RXN$AMPSYN-RXN PWY-6123$PWY-6126 2018-01-17 15:23:43 no Is involved in purine ribonucleotide biosynthesis. Catalyses the following reactions: N(6)-(1,2-dicarboxyethyl)AMP <=> fumarate + AMP; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate <=> fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. 2 vladimir 0.247994 0.3020 0.245077 0.20496 0.547046 0.452954 0.262582 0.218818 0.367615 0.150985 0.586433 0.413567 0.308534 0.249453 0.135667 0.306346 0.38512 0.61488 0.172867 0.437637 0.231947 0.157549 0.669584 0.330416 0.735605 50463.185 -0.043202 0.276316 0.489035 0.241228 0.105263 0.583333 0.416667 0.243421 0.122807 0.120614 5.694496 9.407895 NMV_0311 2191273 CDS +1 294595 296463 1869 validated/Curated no putative inner-membrane acyltransferase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2.3.1.- 2018-01-17 15:26:46 no Belongs to the acyltransferase 3 family. 1 vladimir 0.23114 0.2643 0.235955 0.268593 0.500268 0.499732 0.23756 0.252006 0.272873 0.23756 0.52488 0.47512 0.279294 0.215088 0.158909 0.346709 0.373997 0.626003 0.176565 0.325843 0.276083 0.221509 0.601926 0.398074 0.527845 70667.835 0.161254 0.258842 0.434084 0.266881 0.157556 0.615756 0.384244 0.20418 0.128617 0.075563 9.338585 8.842444 NMV_0312 2191274 CDS -3 296754 297368 615 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2008-02-13 15:37:22 no 2 vladimir 0.255285 0.2927 0.274797 0.177236 0.56748 0.43252 0.268293 0.190244 0.385366 0.156098 0.57561 0.42439 0.278049 0.278049 0.195122 0.24878 0.473171 0.526829 0.219512 0.409756 0.243902 0.126829 0.653659 0.346341 0.61777 22018.035 -0.202941 0.377451 0.529412 0.196078 0.068627 0.539216 0.460784 0.22549 0.107843 0.117647 5.361885 9.490196 NMV_0313 2191275 CDS -3 297405 299555 2151 validated/Curated no putative ATP-dependent helicase DinG (DNA-damage-inducible protein G) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.6.4.12 RXN-11135 2018-01-22 16:52:29 no Probable helicase involved in DNA repair and perhaps also replication. 2 vladimir 0.237099 0.3310 0.25616 0.175732 0.587169 0.412831 0.244073 0.27894 0.345886 0.131102 0.624826 0.375174 0.294282 0.238494 0.18689 0.280335 0.425384 0.574616 0.172943 0.475593 0.235704 0.11576 0.711297 0.288703 0.65995 79204.705 -0.209358 0.284916 0.481844 0.23743 0.087989 0.560056 0.439944 0.25838 0.129888 0.128492 5.714684 9.120112 NMV_0315 2191277 CDS +3 299646 299882 237 validated/Curated no hypothetical inner-membrane protein 5 : Unknown function u : unknown 5 : Inner membrane protein 2008-02-13 15:37:52 no 1 vladimir 0.181435 0.1688 0.35865 0.291139 0.527426 0.472574 0.202532 0.189873 0.291139 0.316456 0.481013 0.518987 0.202532 0.189873 0.253165 0.35443 0.443038 0.556962 0.139241 0.126582 0.531646 0.202532 0.658228 0.341772 0.638455 9184.615 0.365385 0.230769 0.410256 0.282051 0.166667 0.717949 0.282051 0.179487 0.102564 0.076923 8.009743 10.025641 NMV_0316 2191278 CDS -2 299965 300135 171 validated/Curated partial truncated ISNme1 transposase (N-terminal 17% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-17 15:29:29 no Belongs to the IS5 family. 2 vladimir 0.258065 0.3280 0.193548 0.22043 0.521505 0.478495 0.241935 0.354839 0.225806 0.177419 0.580645 0.419355 0.354839 0.209677 0.16129 0.274194 0.370968 0.629032 0.177419 0.419355 0.193548 0.209677 0.612903 0.387097 0.708589 7304.22 -0.554098 0.180328 0.377049 0.196721 0.163934 0.557377 0.442623 0.262295 0.180328 0.081967 9.871468 9.934426 NMV_0318 2191280 CDS +1 300298 302886 2589 validated/Curated no putative modification methylase (cytosine-specific methyltransferase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.37 2.1.1.113-RXN$2.1.1.72-RXN$DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-17 15:29:55 no Belongs to the family of C-5 cytosine-specific DNA methylases that specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. These enzymes are components of restriction-modification systems. 3 vladimir 0.326381 0.2032 0.179606 0.290846 0.382773 0.617227 0.336037 0.202781 0.266512 0.19467 0.469293 0.530707 0.375435 0.198146 0.125145 0.301275 0.323291 0.676709 0.267671 0.208575 0.147161 0.376593 0.355736 0.644264 0.615321 99089.575 -0.356729 0.227378 0.448956 0.221578 0.13109 0.5058 0.4942 0.257541 0.146172 0.111369 8.859535 9.076566 NMV_0319 2191281 CDS +3 302898 304058 1161 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2008-02-13 15:38:53 no 3 vladimir 0.360896 0.1886 0.159345 0.291128 0.347976 0.652024 0.377261 0.167959 0.250646 0.204134 0.418605 0.581395 0.405685 0.191214 0.121447 0.281654 0.312661 0.687339 0.299742 0.206718 0.105943 0.387597 0.312661 0.687339 0.607566 44848.205 -0.479016 0.238342 0.450777 0.189119 0.15544 0.481865 0.518135 0.261658 0.147668 0.11399 8.129585 9.414508 NMV_0320 2191282 CDS -3 304122 304493 372 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 15:39:07 no 3 vladimir 0.333333 0.1317 0.201613 0.333333 0.333333 0.666667 0.314516 0.169355 0.298387 0.217742 0.467742 0.532258 0.370968 0.16129 0.16129 0.306452 0.322581 0.677419 0.314516 0.064516 0.145161 0.475806 0.209677 0.790323 0.488789 13692.92 -0.227642 0.268293 0.495935 0.195122 0.146341 0.552846 0.447154 0.195122 0.113821 0.081301 7.796013 9.121951 NMV_0321 2191283 CDS -1 304808 305341 534 validated/Curated partial truncated ISNme1 transposase (C-terminal half of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-17 15:30:41 no Belongs to the IS5 family. 2 vladimir 0.288889 0.2889 0.251282 0.17094 0.540171 0.459829 0.276923 0.271795 0.292308 0.158974 0.564103 0.435897 0.364103 0.25641 0.184615 0.194872 0.441026 0.558974 0.225641 0.338462 0.276923 0.158974 0.615385 0.384615 0.607883 21756.985 -0.752062 0.304124 0.469072 0.159794 0.113402 0.494845 0.505155 0.304124 0.201031 0.103093 9.590981 9.391753 NMV_0322 2191284 CDS -1 305498 306799 1302 validated/Curated no phr deoxyribodopyrimidine photo-lyase (DNA photolyase; photoreactivating enzyme) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 4.1.99.3 DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN 2018-01-17 15:31:29 no Is a DNA repair enzyme that binds to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), catalyses the following reaction: cyclobutadipyrimidine (in DNA) <=> 2 pyrimidine residues (in DNA). 2 vladimir 0.185868 0.3763 0.24808 0.189708 0.624424 0.375576 0.179724 0.304147 0.343318 0.172811 0.647465 0.352535 0.260369 0.301843 0.198157 0.239631 0.5 0.5 0.117512 0.523041 0.202765 0.156682 0.725806 0.274194 0.623965 48279.86 -0.293764 0.316397 0.528868 0.187067 0.13164 0.570439 0.429561 0.26097 0.145497 0.115473 6.640953 9.725173 NMV_0323 2191285 CDS -3 306789 307700 912 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-17 15:31:46 no Belongs to the LysR bacterial regulatory protein family. 2 vladimir 0.230263 0.3202 0.279605 0.169956 0.599781 0.400219 0.246711 0.273026 0.342105 0.138158 0.615132 0.384868 0.276316 0.236842 0.203947 0.282895 0.440789 0.559211 0.167763 0.450658 0.292763 0.088816 0.743421 0.256579 0.632635 33680.48 -0.162706 0.30363 0.49835 0.234323 0.089109 0.557756 0.442244 0.250825 0.138614 0.112211 8.545509 9.663366 NMV_0325 2191287 CDS +2 307808 308206 399 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-02-13 15:40:03 no 1 vladimir 0.135338 0.2632 0.293233 0.308271 0.556391 0.443609 0.172932 0.180451 0.360902 0.285714 0.541353 0.458647 0.135338 0.24812 0.203008 0.413534 0.451128 0.548872 0.097744 0.360902 0.315789 0.225564 0.676692 0.323308 0.697917 13900.035 1.028788 0.363636 0.507576 0.295455 0.136364 0.765152 0.234848 0.113636 0.075758 0.037879 8.996254 8.44697 NMV_0326 2191288 CDS +2 308255 308860 606 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-17 15:32:28 no Belongs to the NADH oxidase/flavin reductase family of proteins. 1 vladimir 0.239274 0.2541 0.267327 0.239274 0.521452 0.478548 0.19802 0.212871 0.410891 0.178218 0.623762 0.376238 0.321782 0.267327 0.123762 0.287129 0.391089 0.608911 0.19802 0.282178 0.267327 0.252475 0.549505 0.450495 0.728551 22123.19 -0.069652 0.283582 0.532338 0.223881 0.119403 0.587065 0.412935 0.20398 0.099502 0.104478 5.378014 9.522388 NMV_0327 2191289 CDS +1 309046 311157 2112 validated/Curated no putative TonB-dependent receptor 3 : Putative function from multiple computational evidences rc : receptor 7 : Outer membrane protein 2018-03-22 17:53:18 no TonB interacts with outer-membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space. In the absence of TonB these receptors bind their substrates but do not carry out active transport. 2 vladimir 0.263258 0.3106 0.230587 0.195549 0.541193 0.458807 0.302557 0.208807 0.308239 0.180398 0.517045 0.482955 0.335227 0.215909 0.214489 0.234375 0.430398 0.569602 0.151989 0.507102 0.169034 0.171875 0.676136 0.323864 0.701779 79028.99 -0.604267 0.301565 0.543385 0.180654 0.135135 0.503556 0.496444 0.229018 0.13798 0.091038 9.533409 9.755334 NMV_0328 2191290 CDS +1 311272 311967 696 validated/Curated no dsbA2 thiol:disulfide interchange lipoprotein DsbA2 1a : Function from experimental evidences in the studied strain e : enzyme 11 : Membrane 2008-02-13 15:41:03 no 15105427 2 vladimir 0.288793 0.2443 0.252874 0.21408 0.497126 0.502874 0.280172 0.185345 0.357759 0.176724 0.543103 0.456897 0.340517 0.271552 0.12931 0.258621 0.400862 0.599138 0.24569 0.275862 0.271552 0.206897 0.547414 0.452586 0.758135 25401.96 -0.301299 0.316017 0.510823 0.190476 0.090909 0.515152 0.484848 0.255411 0.125541 0.12987 5.443703 8.974026 NMV_0329 2191291 CDS -2 312298 313668 1371 validated/Curated no ffh signal recognition particle protein (fifty-four homolog) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:20:53 no This is the protein component of the signal recognition particle (SRP), a universally conserved RNA:protein (ribonucleoprotein) complex involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. SRP binds to the hydrophobic signal sequence of the ribosome-nascent chain as it emerges from the ribosomes. 1 vladimir 0.277899 0.2553 0.274252 0.19256 0.529541 0.47046 0.301969 0.203501 0.396061 0.098468 0.599562 0.400438 0.326039 0.205689 0.142232 0.326039 0.347921 0.652079 0.205689 0.356674 0.284464 0.153173 0.641138 0.358862 0.713291 49475.665 -0.140789 0.269737 0.489035 0.236842 0.048246 0.565789 0.434211 0.263158 0.144737 0.118421 9.253029 9.320175 NMV_0330 2191292 CDS +1 313888 314694 807 validated/Curated no putative cytochrome c biogenesis protein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-31 14:37:11 no Belongs to a family of integral membrane proteins comprising the membrane component of an ABC (ATP binding cassette) transporter complex important for cytochrome c assembly. This transporter may therefore be necessary for transport of some components needed for cytochrome c assembly. 1 vladimir 0.201983 0.2515 0.263941 0.282528 0.515489 0.484511 0.260223 0.223048 0.271375 0.245353 0.494424 0.505576 0.171004 0.208178 0.193309 0.427509 0.401487 0.598513 0.174721 0.32342 0.327138 0.174721 0.650558 0.349442 0.637935 29797.745 0.833582 0.309701 0.425373 0.294776 0.175373 0.723881 0.276119 0.126866 0.097015 0.029851 9.824898 8.231343 NMNmiscRNA0144 54894438 misc_RNA -1 314811 314935 125 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-28 20:43:45 28334889 Function unknown but has three paralogs. vladimir NMV_16S_3 2194878 rRNA +1 315151 316695 1545 validated/Curated no ribosomal RNA 16S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:03:50 vladimir NMV_tRNA_11 2194826 tRNA +1 316793 316869 77 validated/Curated no Ile tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:48:37 no tRNA Ile anticodon GAT. vladimir NMV_tRNA_12 2194827 tRNA +1 316875 316950 76 validated/Curated no Ala tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:48:46 no tRNA Ala anticodon TGC. vladimir NMV_23S_3 2194882 rRNA +1 317346 320248 2903 validated/Curated no ribosomal RNA 23S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:03:59 vladimir NMV_5S_3 2194886 rRNA +1 320342 320458 117 validated/Curated no ribosomal RNA 5S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:06 vladimir NMV_0333 2191295 CDS +1 320659 320958 300 validated/Curated no comE2 DNA-binding competence protein ComE2 1c : Function from experimental evidences in the studied genus f : factor 11 : Membrane 2018-01-17 15:35:05 no 11325945 ComE is a DNA-binding protein involved in neisserial competence. The comE gene is present in four copies in the genome, located downstream of each of the rRNA operons. 1 vladimir 0.230108 0.2430 0.305376 0.221505 0.548387 0.451613 0.264516 0.206452 0.341935 0.187097 0.548387 0.451613 0.245161 0.277419 0.174194 0.303226 0.451613 0.548387 0.180645 0.245161 0.4 0.174194 0.645161 0.354839 0.54012 16527.075 0.105844 0.331169 0.512987 0.214286 0.084416 0.642857 0.357143 0.227273 0.175325 0.051948 10.242104 8.857143 NMV_0335 2191297 CDS +2 321371 322378 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-17 15:35:18 no Belongs to the IS5 family. 2 vladimir 0.280754 0.2966 0.233135 0.189484 0.529762 0.470238 0.276786 0.285714 0.279762 0.157738 0.565476 0.434524 0.357143 0.205357 0.190476 0.247024 0.395833 0.604167 0.208333 0.39881 0.229167 0.16369 0.627976 0.372024 0.671125 38472.56 -0.577313 0.271642 0.426866 0.202985 0.116418 0.483582 0.516418 0.298507 0.185075 0.113433 9.396797 9.429851 NMV_0336 2191298 CDS +1 322924 323577 654 validated/Curated no IS1016 group transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-02-13 15:44:35 no 1 vladimir 0.272171 0.2263 0.247706 0.253823 0.474006 0.525994 0.293578 0.211009 0.311927 0.183486 0.522936 0.477064 0.334862 0.151376 0.206422 0.307339 0.357798 0.642202 0.188073 0.316514 0.224771 0.270642 0.541284 0.458716 0.633966 24845.84 -0.339171 0.235023 0.451613 0.235023 0.129032 0.520737 0.479263 0.317972 0.211982 0.105991 9.887489 9.105991 NMV_0337 2191299 CDS +3 323742 323951 210 validated/Curated partial truncated IS630 family transposase (C-terminal 20% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 12:30:59 no 1 vladimir 0.257778 0.1956 0.222222 0.324444 0.417778 0.582222 0.2 0.24 0.28 0.28 0.52 0.48 0.333333 0.186667 0.133333 0.346667 0.32 0.68 0.24 0.16 0.253333 0.346667 0.413333 0.586667 0.522263 8769.905 -0.128378 0.162162 0.391892 0.27027 0.162162 0.594595 0.405405 0.283784 0.162162 0.121622 8.256371 9.486486 NMV_0338 2191300 CDS -1 323957 324211 255 validated/Curated partial truncated Opc-like protein (C-terminal third of the protein) 5 : Unknown function m : membrane component 11 : Membrane 2018-01-17 15:35:44 no Opc (formerly called 5C) is one of the major outer-membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of both epithelial and endothelial cells. 2 vladimir 0.297491 0.2509 0.243728 0.207885 0.494624 0.505376 0.354839 0.150538 0.290323 0.204301 0.44086 0.55914 0.333333 0.182796 0.247312 0.236559 0.430108 0.569892 0.204301 0.419355 0.193548 0.182796 0.612903 0.387097 0.698836 10311.475 -0.630435 0.336957 0.51087 0.173913 0.097826 0.467391 0.532609 0.293478 0.206522 0.086957 9.910027 8.934783 NMV_0341 2191303 CDS +3 325044 326099 1056 validated/Curated no aroG phospho-2-dehydro-3-deoxyheptonate aldolase (phospho-2-keto-3-deoxyheptonate aldolase; DAHP synthetase; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 2.5.1.54 DAHPSYN-RXN PWY-6164 2018-01-29 22:56:15 no Catalyses the first step in aromatic amino acid biosynthesis from chorismate: phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O <=> 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. 1 vladimir 0.243371 0.2320 0.294508 0.230114 0.526515 0.473485 0.272727 0.193182 0.357955 0.176136 0.551136 0.448864 0.326705 0.213068 0.190341 0.269886 0.403409 0.596591 0.130682 0.289773 0.335227 0.244318 0.625 0.375 0.680643 38640.52 -0.290598 0.299145 0.490028 0.225071 0.102564 0.538462 0.461538 0.287749 0.159544 0.128205 6.274376 9.413105 NMV_0342 2191304 CDS +1 326167 326655 489 validated/Curated no folA dihydrofolate reductase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 1.5.1.3 DIHYDROFOLATEREDUCT-RXN 1CMET2-PWY$PWY-6614 2020-02-21 16:02:28 no Catalyses the following reaction: 5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH. This is a key step in the de novo synthesis of glycine, purines and deoxythymidine phosphate (the precursors of DNA synthesis). It is important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. 1 vladimir 0.251534 0.2413 0.304703 0.202454 0.546012 0.453988 0.257669 0.165644 0.392638 0.184049 0.558282 0.441718 0.257669 0.276074 0.202454 0.263804 0.478528 0.521472 0.239264 0.282209 0.319018 0.159509 0.601227 0.398773 0.540467 17799.835 0.017284 0.345679 0.506173 0.197531 0.117284 0.623457 0.376543 0.240741 0.123457 0.117284 5.942726 9.938272 NMNmiscRNA0078 52714413 misc_RNA +1 326715 327019 305 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:41:09 28334889 Function unknown. vladimir NMNmiscRNA0076 52714410 misc_RNA -1 326744 326884 141 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:44:22 28334889 Function unknown. vladimir NMV_0343 2191305 CDS -1 327005 327481 477 validated/Curated no putative adenylate cyclase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic ADENYLATECYC-RXN 2018-01-17 15:39:00 no Belongs to the adenylate cyclase family, which catalyse the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. 1 vladimir 0.243187 0.2222 0.291405 0.243187 0.513627 0.486373 0.251572 0.213836 0.345912 0.188679 0.559748 0.440252 0.308176 0.176101 0.226415 0.289308 0.402516 0.597484 0.169811 0.27673 0.301887 0.251572 0.578616 0.421384 0.636333 18569.515 -0.439873 0.21519 0.424051 0.202532 0.132911 0.556962 0.443038 0.303797 0.132911 0.170886 4.867027 10.246835 NMV_0344 2191306 CDS -2 327493 327921 429 validated/Curated no putative HemJ-like protoporphyrinogen oxidase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 1.5.3.12 : Heme, porphyrin ; 2020-02-26 11:17:13 no 20823222, 29925590 HemJ from Synechocystis sp. has protoporphyrinogen IX oxidase activity and is functionally coupled with coproporphyrinogen III oxidase. 1 vladimir 0.135198 0.2378 0.305361 0.321678 0.543124 0.456876 0.167832 0.230769 0.286713 0.314685 0.517483 0.482517 0.174825 0.174825 0.20979 0.440559 0.384615 0.615385 0.062937 0.307692 0.41958 0.20979 0.727273 0.272727 0.703632 16633.305 0.741549 0.225352 0.422535 0.267606 0.239437 0.760563 0.239437 0.140845 0.105634 0.035211 9.795097 9.422535 NMV_0345 2191307 CDS +1 328033 328278 246 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2008-02-13 15:46:14 no 1 vladimir 0.304878 0.2520 0.239837 0.203252 0.49187 0.50813 0.329268 0.243902 0.268293 0.158537 0.512195 0.487805 0.378049 0.146341 0.182927 0.292683 0.329268 0.670732 0.207317 0.365854 0.268293 0.158537 0.634146 0.365854 0.614601 9515.73 -0.591358 0.222222 0.333333 0.197531 0.111111 0.493827 0.506173 0.320988 0.209877 0.111111 9.912376 9.493827 NMV_0346 2191308 CDS +3 330027 331886 1860 validated/Curated no autA autotransporter A 1b : Function from experimental evidences in the studied species f : factor 7 : Outer membrane protein 2018-03-22 17:54:38 no 10972828 Belongs to the family of autotransporters where the signal that mediates secretion through the outer-membrane is contained within the C-terminus of the secreted protein itself. The N-terminal part of the protein contains a pectin lyase fold and might adopt a beta-helix topology found in many virulence factors. 1 vladimir 0.276344 0.2333 0.274731 0.215591 0.508065 0.491935 0.254839 0.203226 0.364516 0.177419 0.567742 0.432258 0.359677 0.196774 0.214516 0.229032 0.41129 0.58871 0.214516 0.3 0.245161 0.240323 0.545161 0.454839 0.596258 68719.26 -0.642326 0.306947 0.495961 0.177706 0.119548 0.510501 0.489499 0.274637 0.163166 0.11147 9.436317 9.455574 NMV_0347 2191309 CDS +1 332161 333594 1434 validated/Curated no conserved hypothetical TPR-containing periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-17 15:40:21 no Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.243354 0.2529 0.300613 0.203136 0.553511 0.446489 0.241309 0.235174 0.323108 0.200409 0.558282 0.441718 0.331288 0.212679 0.222904 0.233129 0.435583 0.564417 0.157464 0.310838 0.355828 0.175869 0.666667 0.333333 0.597275 56203.565 -0.716393 0.266393 0.456967 0.168033 0.133197 0.516393 0.483607 0.286885 0.180328 0.106557 9.986717 10.071721 NMV_0348 2191310 CDS -3 333795 334763 969 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 15:47:05 no 2 vladimir 0.216718 0.2982 0.28999 0.195046 0.588235 0.411765 0.201238 0.281734 0.328173 0.188854 0.609907 0.390093 0.28483 0.235294 0.22291 0.256966 0.458204 0.541796 0.164087 0.377709 0.318885 0.139319 0.696594 0.303406 0.619372 36865.635 -0.363975 0.279503 0.47205 0.201863 0.145963 0.565217 0.434783 0.270186 0.145963 0.124224 6.278221 9.63354 NMV_0349 2191311 CDS +2 334841 336133 1293 validated/Curated no putative metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 3.4.24.- 2018-01-17 15:41:27 no Belongs to MEROPS peptidase family M23 (clan M-), subfamily M23B. 1 vladimir 0.193349 0.2622 0.344161 0.200309 0.606342 0.393658 0.180974 0.232019 0.422274 0.164733 0.654292 0.345708 0.273782 0.25522 0.218097 0.2529 0.473318 0.526682 0.12529 0.299304 0.392111 0.183295 0.691415 0.308585 0.576823 46461.615 -0.275814 0.339535 0.537209 0.211628 0.104651 0.569767 0.430233 0.255814 0.148837 0.106977 9.248009 9.634884 NMV_0350 2191312 CDS -3 336669 337355 687 validated/Curated no queuosine precursor transporter 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 2018-01-17 15:42:11 no 28208705 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ0) and 7-aminomethyl-7-deazaguanine (preQ1), with a preference for preQ0. 2 vladimir 0.190684 0.3086 0.219796 0.280932 0.528384 0.471616 0.235808 0.235808 0.275109 0.253275 0.510917 0.489083 0.200873 0.257642 0.139738 0.401747 0.39738 0.60262 0.135371 0.432314 0.244541 0.187773 0.676856 0.323144 0.671724 25681.275 0.737719 0.302632 0.460526 0.267544 0.201754 0.684211 0.315789 0.114035 0.078947 0.035088 9.633492 8.162281 NMV_0351 2191313 CDS -1 337430 337903 474 validated/Curated no queF NADPH-dependent 7-cyano-7-deazaguanine reductase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 1.7.1.13 RXN0-4022 PWY-6700 2018-01-30 10:06:01 no Catalyses the following reaction: 7-aminomethyl-7-carbaguanine + 2 NADP+ <=> 7-cyano-7-carbaguanine + 2 NADPH. 2 vladimir 0.2827 0.3186 0.191983 0.206751 0.510549 0.489451 0.297468 0.227848 0.278481 0.196203 0.506329 0.493671 0.373418 0.183544 0.14557 0.297468 0.329114 0.670886 0.177215 0.544304 0.151899 0.126582 0.696203 0.303797 0.775077 18122.03 -0.365605 0.229299 0.433121 0.184713 0.171975 0.547771 0.452229 0.273885 0.140127 0.133758 5.652412 9.541401 NMV_misc_RNA_3 2194962 misc_RNA -1 337908 337948 41 validated/Curated no PreQ1 riboswitch 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:45:19 28334889 The PreQ1-I riboswitch is a cis-acting element identified in bacteria which regulates expression of genes involved in biosynthesis of the nucleoside queuosine from GTP. This RNA element binds preQ1 (pre-queuosine1), an intemediate in the queuosine pathway. vladimir NMV_0352 2191314 CDS +2 338192 339346 1155 validated/Curated no emrA multidrug export protein A 1c : Function from experimental evidences in the studied genus t : transporter 5 : Inner membrane protein 2018-01-17 15:43:53 no 10447892 EmrAB confers resistance to various toxic compounds such as antibacterial fatty acids in N. gonorrhoeae. EmrA encodes a peptide containing a single hydrophobic domain and a large C-terminal hydrophilic domain. 1 vladimir 0.203463 0.2502 0.354113 0.192208 0.604329 0.395671 0.171429 0.236364 0.451948 0.14026 0.688312 0.311688 0.285714 0.301299 0.166234 0.246753 0.467532 0.532468 0.153247 0.212987 0.444156 0.18961 0.657143 0.342857 0.598186 41300.955 -0.263802 0.335938 0.567708 0.221354 0.057292 0.536458 0.463542 0.257812 0.140625 0.117188 9.054573 9.625 NMV_0353 2191315 CDS +1 339370 340896 1527 validated/Curated no emrB multidrug export protein B 1c : Function from experimental evidences in the studied genus t : transporter 5 : Inner membrane protein 2018-01-18 18:48:26 no 10447892 EmrAB confers resistance to various toxic compounds such as antibacterial fatty acids in N. gonorrhoeae. EmrB encodes a highly hydrophobic protein. 1 vladimir 0.193189 0.2659 0.26981 0.27112 0.535691 0.464309 0.267191 0.18664 0.328094 0.218075 0.514735 0.485265 0.170923 0.263261 0.178782 0.387033 0.442043 0.557957 0.141454 0.347741 0.302554 0.208251 0.650295 0.349705 0.629826 55014.695 0.710039 0.332677 0.517717 0.295276 0.135827 0.690945 0.309055 0.122047 0.072835 0.049213 7.911156 8.629921 NMV_0355 2191317 CDS +1 341146 341379 234 validated/Curated no rpmB 50S ribosomal protein L28 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-17 15:44:47 no Is one of the proteins from the large ribosomal subunit. 3 vladimir 0.247863 0.2607 0.252137 0.239316 0.512821 0.487179 0.25641 0.230769 0.333333 0.179487 0.564103 0.435897 0.269231 0.205128 0.25641 0.269231 0.461538 0.538462 0.217949 0.346154 0.166667 0.269231 0.512821 0.48718 0.84033 8817.84 -0.575325 0.25974 0.532468 0.220779 0.064935 0.480519 0.519481 0.311688 0.233766 0.077922 11.714607 10.493506 NMV_0356 2191318 CDS +1 341407 341562 156 validated/Curated no rpmG 50S ribosomal protein L33 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-17 15:45:01 no Is one of the proteins from the large ribosomal subunit. 1 vladimir 0.397436 0.2564 0.173077 0.173077 0.429487 0.570513 0.442308 0.192308 0.25 0.115385 0.442308 0.557692 0.423077 0.211538 0.134615 0.230769 0.346154 0.653846 0.326923 0.365385 0.134615 0.173077 0.5 0.5 0.871416 5936.78 -0.992157 0.254902 0.411765 0.156863 0.117647 0.411765 0.588235 0.411765 0.313725 0.098039 10.197884 8.647059 NMV_0358 2191320 CDS -2 341833 343017 1185 validated/Curated no putative ubiquinone biosynthesis hydroxylase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 1.14.13.- 2020-02-25 20:10:29 no Represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF. UbiH and UbiF are similar to one another and form the basis of this subfamily. 1 vladimir 0.259916 0.2970 0.23038 0.212658 0.527426 0.472574 0.281013 0.270886 0.311392 0.136709 0.582278 0.417722 0.306329 0.21519 0.177215 0.301266 0.392405 0.607595 0.192405 0.405063 0.202532 0.2 0.607595 0.392405 0.719562 43590.435 -0.167259 0.28934 0.477157 0.246193 0.101523 0.538071 0.461929 0.253807 0.149746 0.104061 7.911369 9.152284 NMV_0359 2191321 CDS -1 343406 343678 273 validated/Curated no rpmA 50S ribosomal protein L27 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-17 15:46:05 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.300366 0.2674 0.245421 0.186813 0.512821 0.48718 0.318681 0.153846 0.395604 0.131868 0.549451 0.450549 0.32967 0.208791 0.252747 0.208791 0.461538 0.538462 0.252747 0.43956 0.087912 0.21978 0.527473 0.472527 0.883992 9684.555 -0.691111 0.366667 0.544444 0.155556 0.088889 0.5 0.5 0.311111 0.211111 0.1 10.056999 9.433333 NMV_0360 2191322 CDS -1 343703 344011 309 validated/Curated no rplU 50S ribosomal protein L21 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-17 15:46:26 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.339806 0.2524 0.229773 0.177994 0.482201 0.517799 0.281553 0.203883 0.407767 0.106796 0.61165 0.38835 0.368932 0.165049 0.165049 0.300971 0.330097 0.669903 0.368932 0.38835 0.116505 0.126214 0.504854 0.495146 0.827652 11447.915 -0.335294 0.245098 0.421569 0.245098 0.088235 0.529412 0.470588 0.323529 0.215686 0.107843 9.935661 9.539216 NMV_0362 2191324 CDS +3 344235 345209 975 validated/Curated no ispB octaprenyl diphosphate synthase (octaprenyl pyrophosphate synthetase; OPP synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 2.5.1.90 RXN-8992 PWY-5783 2018-01-22 19:47:41 no Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone. 1 vladimir 0.245128 0.2328 0.284103 0.237949 0.516923 0.483077 0.246154 0.175385 0.424615 0.153846 0.6 0.4 0.329231 0.227692 0.135385 0.307692 0.363077 0.636923 0.16 0.295385 0.292308 0.252308 0.587692 0.412308 0.692337 35519.975 -0.036728 0.290123 0.512346 0.25 0.083333 0.564815 0.435185 0.259259 0.108025 0.151235 4.656502 9.685185 NMV_0363 2191325 CDS +1 345214 345660 447 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-13 15:51:42 no 1 vladimir 0.176734 0.2036 0.293065 0.326622 0.496644 0.503356 0.275168 0.187919 0.33557 0.201342 0.52349 0.47651 0.134228 0.208054 0.154362 0.503356 0.362416 0.637584 0.120805 0.214765 0.389262 0.275168 0.604027 0.395973 0.540934 15374.055 1.328378 0.290541 0.527027 0.405405 0.081081 0.763514 0.236486 0.054054 0.040541 0.013514 9.997185 7.790541 NMV_tRNA_13 2194828 tRNA +1 345680 345751 72 validated/Curated no Arg tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:49:12 no tRNA Arg anticodon CCT. vladimir NMV_0364 2191326 CDS +1 346150 347826 1677 validated/Curated no pilF type IV pilus extension ATPase PilF 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-26 11:04:48 no 15612916, 7565116, 28588140 Cytosolic ATPase that powers pilus extension. Is required for pilus biogenesis. 1 vladimir 0.216458 0.2177 0.31127 0.254621 0.528921 0.471079 0.250447 0.21288 0.363148 0.173524 0.576029 0.423971 0.302326 0.21288 0.162791 0.322004 0.375671 0.624329 0.096601 0.227191 0.407871 0.268336 0.635063 0.364937 0.582596 61976.685 -0.127778 0.267025 0.491039 0.252688 0.080645 0.541219 0.458781 0.258065 0.12724 0.130824 5.483543 9.553763 NMV_0365 2191327 CDS -2 347911 348120 210 validated/Curated no yacG DNA gyrase inhibitor YacG 2a : Function from experimental evidences in other organisms f : factor 1 : Unknown 2020-04-21 14:22:36 no 18586829 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. 2 vladimir 0.285714 0.2762 0.252381 0.185714 0.528571 0.471429 0.214286 0.242857 0.3 0.242857 0.542857 0.457143 0.285714 0.271429 0.242857 0.2 0.514286 0.485714 0.357143 0.314286 0.214286 0.114286 0.528571 0.471429 0.621342 7841.61 -0.598551 0.333333 0.521739 0.144928 0.086957 0.507246 0.492754 0.246377 0.115942 0.130435 5.255821 10.536232 NMV_0366 2191328 CDS -1 348113 348745 633 validated/Curated no coaE dephospho-CoA kinase (dephosphocoenzyme A kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.5 : Coenzyme A ; 2.7.1.24 DEPHOSPHOCOAKIN-RXN COA-PWY 2018-01-17 15:50:10 no Catalyses the following reaction: ATP + dephospho-CoA <=> ADP + CoA. 1 vladimir 0.240126 0.2765 0.28278 0.200632 0.559242 0.440758 0.255924 0.246445 0.345972 0.151659 0.592417 0.407583 0.241706 0.241706 0.203791 0.312796 0.445498 0.554502 0.222749 0.341232 0.298578 0.137441 0.63981 0.36019 0.605227 22975.665 -0.02381 0.32381 0.480952 0.252381 0.07619 0.542857 0.457143 0.271429 0.152381 0.119048 9.098793 8.657143 NMV_0367 2191329 CDS -3 348747 349607 861 validated/Curated no pilD leader peptidase / N-methyltransferase PilD 1a : Function from experimental evidences in the studied strain e : enzyme 5 : Inner membrane protein 6.5 : Pilus ; 3.4.23.43 3.4.23.43-RXN 2020-04-26 11:03:49 no 7565116, 28588140 Proteolytically removes the leader peptide from major and minor prepilins, and subsequently methylates the newly exposed N-terminal residue. Is required for pilus biogenesis. 1 vladimir 0.181185 0.2578 0.283391 0.277584 0.541231 0.458769 0.219512 0.209059 0.317073 0.254355 0.526132 0.473868 0.170732 0.233449 0.195122 0.400697 0.428571 0.571429 0.15331 0.33101 0.337979 0.1777 0.66899 0.33101 0.659609 31344.065 0.804545 0.304196 0.506993 0.325175 0.129371 0.716783 0.283217 0.122378 0.06993 0.052448 8.533226 8.520979 NMV_0368 2191330 CDS -2 349681 350913 1233 validated/Curated no pilG type IV pilus biogenesis protein PilG 1a : Function from experimental evidences in the studied strain f : factor 5 : Inner membrane protein 6.5 : Pilus ; 2020-04-25 14:19:05 no 15612916, 7565106, 28588140 Platform protein playing a key role in filament assembly. Is required for pilus biogenesis. 1 vladimir 0.244931 0.2539 0.273317 0.227899 0.527169 0.47283 0.296837 0.177616 0.350365 0.175182 0.527981 0.472019 0.245742 0.23601 0.158151 0.360097 0.394161 0.605839 0.192214 0.347932 0.311436 0.148418 0.659367 0.340633 0.690174 45271.485 0.201463 0.297561 0.465854 0.253659 0.087805 0.597561 0.402439 0.229268 0.129268 0.1 9.415489 9.270732 NMV_0369 2191331 CDS +3 351423 353066 1644 validated/Curated no pgi2 glucose-6-phosphate isomerase 2 (GPI 2; phosphoglucose isomerase 2; PGI 2; phosphohexose isomerase 2; PHI 2) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 5.3.1.9 PGLUCISOM-RXN$RXN-6182 ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-22 17:30:20 no Is a dimeric enzyme that catalyses the following reaction: D-glucose 6-phosphate <=> D-fructose 6-phosphate. 1 vladimir 0.201946 0.2792 0.309002 0.209854 0.588199 0.4118 0.202555 0.248175 0.385036 0.164234 0.633212 0.366788 0.277372 0.231752 0.220803 0.270073 0.452555 0.547445 0.125912 0.357664 0.321168 0.195255 0.678832 0.321168 0.621847 60331.3 -0.184826 0.319927 0.522852 0.193784 0.126143 0.585009 0.414991 0.255941 0.140768 0.115174 6.388344 10.032907 NMV_0371 2191333 CDS +3 353277 354098 822 validated/Curated no dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (tetrahydrodipicolinate N-succinyltransferase; THP succinyltransferase; tetrahydropicolinate succinylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 2.3.1.117 TETHYDPICSUCC-RXN DAPLYSINESYN-PWY 2018-01-17 15:52:20 no Is part of the diaminopimelate pathway of lysine biosynthesis where it catalyses the following reaction: succinyl-CoA + (R)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O <=> CoA + (R)-2-(succinylamino)-6-oxoheptanedioate. 2 vladimir 0.237226 0.2847 0.278589 0.199513 0.56326 0.43674 0.270073 0.149635 0.427007 0.153285 0.576642 0.423358 0.273723 0.215328 0.20438 0.306569 0.419708 0.580292 0.167883 0.489051 0.20438 0.138686 0.693431 0.306569 0.81023 29438.32 -0.003663 0.318681 0.571429 0.252747 0.076923 0.564103 0.435897 0.234432 0.113553 0.120879 5.426506 9.454212 NMV_0372 2191334 CDS +1 354253 355038 786 validated/Curated no fabI enoyl-[acyl-carrier-protein] reductase [NADH] (NADH-dependent enoyl-ACP reductase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 1.3.1.9 ENOYL-ACP-REDUCT-NADH-RXN$ENOYL-ACP-REDUCT-NADPH-RXN$RXN-10657$RXN-10661$RXN-11478$RXN-11482$RXN-9657$RXN-9658$RXN-9659$RXN-9660$RXN-9661$RXN-9662$RXN-9663$RXN0-2145 FASYN-ELONG-PWY$PWY-5971$PWY-6282$PWY-6519$PWY0-862 2020-04-21 14:30:21 no Catalyses the following reaction: acyl-[acyl-carrier protein] + NAD(+) <=> trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH. 2 vladimir 0.225191 0.3053 0.270992 0.198473 0.576336 0.423664 0.263359 0.164122 0.408397 0.164122 0.572519 0.427481 0.259542 0.236641 0.209924 0.293893 0.446565 0.553435 0.152672 0.515267 0.194656 0.137405 0.709924 0.290076 0.807726 27717.59 0.124904 0.367816 0.536398 0.229885 0.088123 0.601533 0.398467 0.233716 0.118774 0.114943 5.789345 9.241379 NMV_0373 2191335 CDS -2 355282 356280 999 validated/Curated no putative branched-chain amino acid aminotransferase (BCAT) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 2.6.1.42 BRANCHED-CHAINAMINOTRANSFERILEU-RXN$BRANCHED-CHAINAMINOTRANSFERLEU-RXN$BRANCHED-CHAINAMINOTRANSFERVAL-RXN ALANINE-VALINESYN-PWY$ILEUSYN-PWY$LEUSYN-PWY$PWY-5057$VALSYN-PWY 2018-01-29 17:34:21 no Catalyses the following reaction: L-leucine + 2-oxoglutarate <=> 4-methyl-2-oxopentanoate + L-glutamate. 2 vladimir 0.227227 0.3113 0.259259 0.202202 0.570571 0.429429 0.228228 0.219219 0.393393 0.159159 0.612613 0.387387 0.285285 0.258258 0.177177 0.279279 0.435435 0.564565 0.168168 0.456456 0.207207 0.168168 0.663664 0.336336 0.757839 36072.845 -0.040361 0.319277 0.533133 0.231928 0.105422 0.593373 0.406627 0.237952 0.120482 0.11747 5.67527 9.403614 NMV_0375 2191337 CDS +1 356590 356904 315 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-13 16:12:59 no 1 vladimir 0.222222 0.2381 0.250794 0.288889 0.488889 0.511111 0.266667 0.209524 0.304762 0.219048 0.514286 0.485714 0.219048 0.228571 0.12381 0.428571 0.352381 0.647619 0.180952 0.27619 0.32381 0.219048 0.6 0.4 0.622135 11464.355 0.6375 0.25 0.451923 0.326923 0.105769 0.673077 0.326923 0.173077 0.115385 0.057692 10.088615 8.307692 NMV_0376 2191338 CDS +2 356915 358084 1170 validated/Curated no LOS assembly protein LapB 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2020-02-21 10:26:31 no 24266962, 24722986 Modulates cellular lipooligosaccharide (LOS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LOS synthesis at the plasma membrane. 2 vladimir 0.260684 0.2692 0.257265 0.212821 0.526496 0.473504 0.246154 0.248718 0.335897 0.169231 0.584615 0.415385 0.361538 0.187179 0.166667 0.284615 0.353846 0.646154 0.174359 0.371795 0.269231 0.184615 0.641026 0.358974 0.617667 44476.19 -0.3491 0.246787 0.439589 0.210797 0.115681 0.542416 0.457584 0.262211 0.138817 0.123393 6.739113 9.799486 NMV_0377 2191339 CDS +2 358109 358525 417 validated/Curated no gloA lactoylglutathione lyase (methylglyoxalase; aldoketomutase; glyoxalase I; Glx I; ketone-aldehyde mutase; S-D-lactoylglutathione methylglyoxal lyase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.7.23 : Methylglyoxal metabolism ; 4.4.1.5 GLYOXI-RXN PWY-5386 2018-01-17 15:55:00 no Catalyses the first step in the glyoxal pathway: (R)-S-lactoylglutathione <=> glutathione + methylglyoxal. 2 vladimir 0.273381 0.2710 0.261391 0.194245 0.532374 0.467626 0.23741 0.194245 0.410072 0.158273 0.604317 0.395683 0.374101 0.165468 0.194245 0.266187 0.359712 0.640288 0.208633 0.453237 0.179856 0.158273 0.633094 0.366906 0.621757 15667.985 -0.528986 0.26087 0.492754 0.202899 0.130435 0.521739 0.478261 0.318841 0.152174 0.166667 5.184258 10.268116 NMV_0378 2191340 CDS -3 358698 361292 2595 validated/Curated no tspA TspA protein 1b : Function from experimental evidences in the studied species ph : phenotype 11 : Membrane 2020-04-20 20:07:54 no 10377136 Contains a LysM domain, which may have a general peptidoglycan binding function, that is found in a variety of enzymes involved in bacterial cell wall degradation. 2 vladimir 0.277778 0.3105 0.240487 0.171233 0.550989 0.449011 0.227169 0.199772 0.445205 0.127854 0.644977 0.355023 0.335616 0.363014 0.091324 0.210046 0.454338 0.545662 0.270548 0.368721 0.184932 0.175799 0.553653 0.446347 0.701017 92523.51 -0.449371 0.346286 0.597714 0.184 0.046857 0.501714 0.498286 0.275429 0.093714 0.181714 4.331047 9.379429 NMV_0379 2191341 CDS +1 361531 362061 531 validated/Curated no putative intracellular septation protein A 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 5.1 : Cell division ; 2020-02-21 16:03:40 no Belongs to a family of proteins, which are important for both normal cell division and bacterial virulence, which are believed to play a role in the septation process. 1 vladimir 0.199623 0.2053 0.288136 0.306968 0.493409 0.506591 0.305085 0.146893 0.310734 0.237288 0.457627 0.542373 0.20339 0.175141 0.19209 0.429379 0.367232 0.632768 0.090395 0.293785 0.361582 0.254237 0.655367 0.344633 0.674879 19954.105 0.811932 0.284091 0.443182 0.295455 0.181818 0.704545 0.295455 0.136364 0.090909 0.045455 9.60807 8.25 NMV_0380 2191342 CDS +3 362064 362354 291 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2020-02-19 15:11:15 no Related to YciI of E. coli. A strongly conserved histidine and a aspartate suggest that it has an enzymatic function. 1 vladimir 0.223368 0.2199 0.33677 0.219931 0.556701 0.443299 0.175258 0.206186 0.42268 0.195876 0.628866 0.371134 0.329897 0.257732 0.134021 0.278351 0.391753 0.608247 0.164948 0.195876 0.453608 0.185567 0.649485 0.350515 0.619217 10680.705 -0.229167 0.270833 0.5 0.21875 0.114583 0.572917 0.427083 0.291667 0.125 0.166667 4.810844 9.65625 NMV_0381 2191343 CDS +2 362354 362632 279 validated/Curated no bolA BolA-like protein 2b : Function from indirect experimental evidences (e.g. phenotypes) ph : phenotype 2 : Cytoplasmic 2018-01-17 15:58:00 no Belongs to a family consisting of the morpho-protein BolA from E. coli and its various homologs. In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. 1 vladimir 0.21147 0.2832 0.301075 0.204301 0.584229 0.415771 0.215054 0.268817 0.387097 0.129032 0.655914 0.344086 0.290323 0.182796 0.225806 0.301075 0.408602 0.591398 0.129032 0.397849 0.290323 0.182796 0.688172 0.311828 0.652808 10002.985 -0.171739 0.304348 0.5 0.25 0.119565 0.554348 0.445652 0.293478 0.173913 0.119565 6.640526 9.173913 NMV_0382 2191344 CDS +2 362681 363547 867 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-02-13 16:19:34 no 1 vladimir 0.296424 0.2503 0.264129 0.189158 0.514418 0.485582 0.266436 0.197232 0.397924 0.138408 0.595156 0.404844 0.387543 0.238754 0.124567 0.249135 0.363322 0.636678 0.235294 0.314879 0.269896 0.179931 0.584775 0.415225 0.715787 31453.565 -0.436458 0.291667 0.513889 0.211806 0.072917 0.517361 0.482639 0.28125 0.15625 0.125 9.228889 8.833333 NMV_0383 2191345 CDS +3 363618 364376 759 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 16:19:50 no 1 vladimir 0.26614 0.2372 0.291173 0.205534 0.528327 0.471673 0.221344 0.252964 0.375494 0.150198 0.628458 0.371542 0.383399 0.213439 0.130435 0.272727 0.343874 0.656126 0.193676 0.245059 0.367589 0.193676 0.612648 0.387352 0.629266 28643.635 -0.556746 0.230159 0.412698 0.198413 0.075397 0.507937 0.492063 0.305556 0.154762 0.150794 7.210472 9.674603 NMV_0384 2191346 CDS +1 364450 364941 492 validated/Curated no dtd D-aminoacyl-tRNA deacylase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.1.96 2018-01-17 16:00:06 no An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. 1 vladimir 0.239837 0.2419 0.302846 0.215447 0.544715 0.455285 0.22561 0.22561 0.396341 0.152439 0.621951 0.378049 0.280488 0.231707 0.176829 0.310976 0.408537 0.591463 0.213415 0.268293 0.335366 0.182927 0.603659 0.396341 0.537747 17704.66 -0.054601 0.312883 0.539877 0.251534 0.092025 0.546012 0.453988 0.282209 0.165644 0.116564 8.591118 9.110429 NMV_0385 2191347 CDS +1 364972 365982 1011 validated/Curated no dusA tRNA-dihydrouridine(20/20a) synthase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.3.1.-, 1.3.1.91 RXN-12456 2018-01-17 16:01:02 no Catalyses the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. 2 vladimir 0.230465 0.3136 0.274975 0.181009 0.588526 0.411474 0.246291 0.249258 0.362018 0.142433 0.611276 0.388724 0.323442 0.195846 0.21365 0.267062 0.409496 0.590504 0.121662 0.495549 0.249258 0.133531 0.744807 0.255193 0.677321 37859.605 -0.371131 0.27381 0.502976 0.21131 0.113095 0.559524 0.440476 0.264881 0.142857 0.122024 6.399132 10.446429 NMV_0386 2191348 CDS -1 366050 366937 888 validated/Curated no gluQ glutamyl-Q tRNA(Asp) synthetase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 6.1.1.- RXN0-5422 2018-01-30 15:50:37 no Is a tRNA-modifying enzyme that ligates a glutamate on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine residue, a modified nucleoside at the wobble position of the tRNA(Asp) QUC anticodon. 2 vladimir 0.210586 0.3491 0.27027 0.170045 0.619369 0.380631 0.155405 0.341216 0.35473 0.148649 0.695946 0.304054 0.293919 0.25 0.222973 0.233108 0.472973 0.527027 0.182432 0.456081 0.233108 0.128378 0.689189 0.310811 0.661295 33021.27 -0.394237 0.294915 0.501695 0.19661 0.128814 0.589831 0.410169 0.247458 0.142373 0.105085 8.058876 10.044068 NMV_0387 2191349 CDS -3 366954 367244 291 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-22 17:58:16 no 3 vladimir 0.333333 0.1753 0.195876 0.295533 0.371134 0.628866 0.340206 0.164948 0.309278 0.185567 0.474227 0.525773 0.360825 0.226804 0.092784 0.319588 0.319588 0.680412 0.298969 0.134021 0.185567 0.381443 0.319588 0.680412 0.487159 10866.015 -0.184375 0.239583 0.427083 0.229167 0.104167 0.541667 0.458333 0.28125 0.104167 0.177083 4.454948 9.15625 NMV_0388 2191350 CDS -3 367386 368441 1056 validated/Curated no tal transaldolase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.3 : Pentose phosphate shunt, non-oxidative branch ; 2.2.1.2 TRANSALDOL-RXN NONOXIPENT-PWY 2018-01-29 17:57:57 no Catalyses the following reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. 2 vladimir 0.238636 0.3248 0.253788 0.182765 0.578598 0.421402 0.21875 0.215909 0.423295 0.142045 0.639205 0.360795 0.289773 0.289773 0.142045 0.278409 0.431818 0.568182 0.207386 0.46875 0.196023 0.127841 0.664773 0.335227 0.6958 37417.28 0.097151 0.358974 0.541311 0.236467 0.082621 0.586895 0.413105 0.22792 0.111111 0.116809 5.361778 9.022792 NMV_0389 2191351 CDS +3 368538 369512 975 validated/Curated no kpsF kdsD arabinose 5-phosphate isomerase 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 5.3.1.13 DARAB5PISOM-RXN KDO-NAGLIPASYN-PWY$PWY-1269 2018-01-17 16:03:45 no 11956197, 12618369 Catalyses the following reaction: D-arabinose 5-phosphate <=> D-ribulose 5-phosphate. 2 vladimir 0.21641 0.3056 0.289231 0.188718 0.594872 0.405128 0.252308 0.209231 0.424615 0.113846 0.633846 0.366154 0.243077 0.273846 0.175385 0.307692 0.449231 0.550769 0.153846 0.433846 0.267692 0.144615 0.701538 0.298462 0.677644 34130.965 0.167901 0.361111 0.564815 0.243827 0.070988 0.592593 0.407407 0.256173 0.135802 0.12037 5.893379 9.33642 NMV_0390 2191352 CDS +1 369577 370113 537 validated/Curated no kdsC 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 3.1.3.45 KDO-8PPHOSPHAT-RXN KDO-NAGLIPASYN-PWY$PWY-1269 2018-01-17 16:04:27 no Catalyses the following reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H(2)O <=> 3-deoxy-D-manno-octulosonate + phosphate. It is involved in lipooligosaccharide synthesis. 1 vladimir 0.217877 0.2737 0.303538 0.204842 0.577281 0.422719 0.206704 0.21229 0.435754 0.145251 0.648045 0.351955 0.290503 0.21229 0.189944 0.307263 0.402235 0.597765 0.156425 0.396648 0.284916 0.162011 0.681564 0.318436 0.69584 19217.375 0.086517 0.303371 0.511236 0.258427 0.08427 0.617978 0.382022 0.252809 0.129213 0.123596 5.80793 9.573034 NMV_0391 2191353 CDS +3 370110 370691 582 validated/Curated no putative lipooligosaccharide export system protein LptC 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 1.6.3 : Lipopolysaccharide ; 2020-02-19 15:26:19 no 1676556 LptC is involved in the translocation of lipooligosaccharide (LOS) from the inner membrane to the outer membrane. It facilitates the transfer of LOS from the inner membrane to a periplasmic chaperone, LptA. 2 vladimir 0.293814 0.2268 0.262887 0.216495 0.489691 0.510309 0.268041 0.170103 0.365979 0.195876 0.536082 0.463918 0.381443 0.190722 0.170103 0.257732 0.360825 0.639175 0.231959 0.319588 0.252577 0.195876 0.572165 0.427835 0.640786 21670.43 -0.532642 0.284974 0.476684 0.186528 0.139896 0.502591 0.497409 0.290155 0.145078 0.145078 5.486748 9.19171 NMV_0392 2191354 CDS +1 370672 371202 531 validated/Curated no putative lipooligosaccharide export system protein LptA 3 : Putative function from multiple computational evidences t : transporter 9 : Periplasmic 1.6.3 : Lipopolysaccharide ; 2020-04-22 17:13:14 no Involved in the assembly of lipooligosaccharide (LOS). Required for the translocation of LOS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LOS transfer across the periplasm. 2 vladimir 0.274953 0.2731 0.250471 0.201507 0.52354 0.47646 0.327684 0.152542 0.361582 0.158192 0.514124 0.485876 0.276836 0.271186 0.20904 0.242938 0.480226 0.519774 0.220339 0.39548 0.180791 0.20339 0.576271 0.423729 0.569027 18425.785 -0.269318 0.409091 0.619318 0.193182 0.056818 0.488636 0.511364 0.176136 0.107955 0.068182 9.807808 8.755682 NMV_0394 2191356 CDS +2 371276 372010 735 validated/Curated no putative lipooligosaccharide export system ATP-binding protein LptB 3 : Putative function from multiple computational evidences t : transporter 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2020-02-19 15:27:33 no Part of the ABC transporter complex LptBFG involved in the translocation of lipooligosaccharide (LOS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system. 1 vladimir 0.266667 0.2797 0.235294 0.218301 0.515033 0.484967 0.282353 0.223529 0.360784 0.133333 0.584314 0.415686 0.294118 0.168627 0.2 0.337255 0.368627 0.631373 0.223529 0.447059 0.145098 0.184314 0.592157 0.407843 0.669678 28034.255 -0.060236 0.255906 0.476378 0.287402 0.070866 0.547244 0.452756 0.275591 0.145669 0.129921 7.111458 8.988189 NMV_tRNA_14 2194829 tRNA +1 372201 372276 76 validated/Curated no Phe tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:49:39 no tRNA Phe anticodon GAA. vladimir NMV_0396 2191358 CDS -1 372479 373180 702 validated/Curated no mtgA biosynthetic peptidoglycan transglycosylase (monofunctional TGase) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.6.7 : Peptidoglycan (murein) ; 2.4.1.129 2.4.1.129-RXN$RXN-11291$RXN-11301$RXN-11348$RXN-11350$RXN0-5405 PEPTIDOGLYCANSYN-PWY$PWY-6385 2018-01-29 18:05:37 no Peptidoglycan polymerase that catalyses glycan chain elongation from lipid-linked precursors. 2 vladimir 0.250712 0.2877 0.264957 0.196581 0.552707 0.447293 0.294872 0.217949 0.324786 0.162393 0.542735 0.457265 0.311966 0.217949 0.196581 0.273504 0.41453 0.58547 0.145299 0.42735 0.273504 0.153846 0.700855 0.299145 0.657039 26534.48 -0.314592 0.27897 0.454936 0.193133 0.141631 0.562232 0.437768 0.257511 0.167382 0.090129 9.893791 9.669528 NMV_0398 2191360 CDS -3 373182 373991 810 validated/Curated no aroE shikimate dehydrogenase (NADP(+)) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 1.1.1.25 SHIKIMATE-5-DEHYDROGENASE-RXN PWY-6163 2018-01-30 13:37:00 no Catalyses the following reaction, which is part of the shikimate pathway involved in the biosynthesis of aromatic amino acids: shikimate + NADP(+) <=> 3-dehydroshikimate + NADPH. 2 vladimir 0.216049 0.2778 0.276543 0.22963 0.554321 0.445679 0.244444 0.203704 0.403704 0.148148 0.607407 0.392593 0.266667 0.251852 0.188889 0.292593 0.440741 0.559259 0.137037 0.377778 0.237037 0.248148 0.614815 0.385185 0.704504 28583.64 0.081413 0.33829 0.550186 0.223048 0.092937 0.628253 0.371747 0.211896 0.115242 0.096654 6.95829 9.483271 NMV_0400 2191362 CDS +2 374822 376240 1419 validated/Curated no glnA glutamine synthetase (glutamate-ammonia ligase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.2 : Glutamine ; 6.3.1.2 GLUTAMINESYN-RXN GLNSYN-PWY 2018-01-17 16:08:44 no Plays an essential role in the metabolism of nitrogen by catalysing the following reaction: ATP + L-glutamate + NH(3) <=> ADP + phosphate + L-glutamine. 2 vladimir 0.244538 0.3009 0.250881 0.203665 0.551797 0.448203 0.247357 0.200846 0.38055 0.171247 0.581395 0.418605 0.325581 0.249471 0.169133 0.255814 0.418605 0.581395 0.160677 0.452431 0.20296 0.183932 0.655391 0.344609 0.829207 52058.505 -0.365042 0.302966 0.523305 0.180085 0.127119 0.550847 0.449153 0.273305 0.131356 0.141949 5.196861 9.466102 NMV_0401 2191363 CDS +1 376396 377679 1284 validated/Curated no putative AmpG-like permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 16:09:06 no The E. coli AmpG protein probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling. Belongs to the major facilitator superfamily. 1 vladimir 0.17134 0.2360 0.314642 0.278037 0.550623 0.449377 0.226636 0.214953 0.338785 0.219626 0.553738 0.446262 0.161215 0.257009 0.179907 0.401869 0.436916 0.563084 0.126168 0.235981 0.425234 0.212617 0.661215 0.338785 0.587221 46346.33 0.748712 0.316159 0.501171 0.295082 0.126464 0.711944 0.288056 0.135831 0.079625 0.056206 9.336769 8.578454 NMV_0402 2191364 CDS +3 377676 377951 276 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-17 16:09:34 no Related to the GIY-YIG endonuclease family. 1 vladimir 0.297101 0.2609 0.275362 0.166667 0.536232 0.463768 0.315217 0.206522 0.326087 0.152174 0.532609 0.467391 0.315217 0.26087 0.195652 0.228261 0.456522 0.543478 0.26087 0.315217 0.304348 0.119565 0.619565 0.380435 0.672716 10029.24 -0.33956 0.340659 0.494505 0.164835 0.087912 0.56044 0.43956 0.21978 0.153846 0.065934 9.744576 9.626374 NMV_0403 2191365 CDS +3 378375 379190 816 validated/Curated no frpD FrpA/C-binding lipoprotein 1b : Function from experimental evidences in the studied species ph : phenotype 8 : Outer membrane-associated 2020-02-19 15:42:18 no 15525636 Is involved in the anchoring of the secreted FrpA/C RTX proteins to the outer membrane. 3 vladimir 0.343137 0.1924 0.197304 0.267157 0.389706 0.610294 0.334559 0.209559 0.268382 0.1875 0.477941 0.522059 0.415441 0.194853 0.143382 0.246324 0.338235 0.661765 0.279412 0.172794 0.180147 0.367647 0.352941 0.647059 0.554581 31436.21 -0.660148 0.239852 0.461255 0.177122 0.151292 0.490775 0.509225 0.239852 0.125461 0.114391 6.111488 9.797048 NMV_0404 2191366 CDS +1 379207 379440 234 validated/Curated partial truncated FrpA/C protein (N-terminal 4% of the protein) 5 : Unknown function f : factor 1 : Unknown 2018-01-17 16:10:11 no Is homologous to the N-terminus of the iron-regulated FrpA/C proteins, which are related to the RTX family of exoproteins. 3 vladimir 0.26087 0.1268 0.275362 0.336957 0.402174 0.597826 0.26087 0.086957 0.391304 0.26087 0.478261 0.521739 0.336957 0.141304 0.206522 0.315217 0.347826 0.652174 0.184783 0.152174 0.228261 0.434783 0.380435 0.619565 0.63526 10306.37 -0.038462 0.252747 0.505495 0.252747 0.131868 0.626374 0.373626 0.21978 0.098901 0.120879 4.887428 10 NMV_0405 2191367 CDS -3 379569 380702 1134 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-02-13 16:25:08 no 1 vladimir 0.251323 0.1905 0.305996 0.252205 0.496473 0.503527 0.21164 0.193122 0.383598 0.21164 0.57672 0.42328 0.359788 0.198413 0.190476 0.251323 0.388889 0.611111 0.18254 0.179894 0.343915 0.293651 0.52381 0.47619 0.545012 43075.61 -0.535544 0.267905 0.482759 0.185676 0.145889 0.527851 0.472149 0.286472 0.143236 0.143236 5.668755 9.941645 NMV_0407 2191369 CDS -3 381081 381362 282 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-17 12:23:54 no 25569427 3 vladimir 0.318627 0.1471 0.191176 0.343137 0.338235 0.661765 0.264706 0.132353 0.279412 0.323529 0.411765 0.588235 0.426471 0.176471 0.073529 0.323529 0.25 0.75 0.264706 0.132353 0.220588 0.382353 0.352941 0.647059 0.56299 8015.68 -0.355224 0.179104 0.41791 0.208955 0.179104 0.492537 0.507463 0.283582 0.089552 0.19403 4.213234 9.626866 NMV_0408 2191370 CDS -2 381340 382014 675 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-17 16:10:49 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 1 vladimir 0.357037 0.2267 0.214815 0.201481 0.441481 0.558519 0.342222 0.2 0.324444 0.133333 0.524444 0.475556 0.422222 0.222222 0.164444 0.191111 0.386667 0.613333 0.306667 0.257778 0.155556 0.28 0.413333 0.586667 0.601257 25009.985 -0.891964 0.290179 0.53125 0.174107 0.111607 0.450893 0.549107 0.28125 0.1875 0.09375 9.705803 9.1875 NMV_0409 2191371 CDS -1 382163 382393 231 validated/Curated no mafI1 MafB1 immunity protein 1a : Function from experimental evidences in the studied strain f : factor 2 : Cytoplasmic 2015-11-13 15:34:07 no 25569427 1 vladimir 0.393939 0.1385 0.164502 0.30303 0.30303 0.69697 0.337662 0.12987 0.311688 0.220779 0.441558 0.558442 0.415584 0.181818 0.090909 0.311688 0.272727 0.727273 0.428571 0.103896 0.090909 0.376623 0.194805 0.805195 0.416621 8825.585 -0.373684 0.236842 0.381579 0.236842 0.092105 0.434211 0.565789 0.342105 0.105263 0.236842 4.212379 8.802632 NMV_0410 2191372 CDS -2 382408 383904 1497 validated/Curated no mafB1 MafB1 toxin 1a : Function from experimental evidences in the studied strain f : factor 10 : Secreted 2015-11-13 15:33:48 no 25569427 2 vladimir 0.304609 0.2886 0.236473 0.170341 0.52505 0.47495 0.318637 0.200401 0.356713 0.124248 0.557114 0.442886 0.348697 0.250501 0.200401 0.200401 0.450902 0.549098 0.246493 0.41483 0.152305 0.186373 0.567134 0.432866 0.562895 54619.595 -0.661044 0.323293 0.552209 0.160643 0.12249 0.516064 0.483936 0.261044 0.156627 0.104418 9.166191 9.819277 NMV_0413 2191375 CDS -2 383908 384849 942 validated/Curated no mafA1 MafA1 lipoprotein 2b : Function from indirect experimental evidences (e.g. phenotypes) m : membrane component 8 : Outer membrane-associated 2008-02-13 16:26:52 no 2 vladimir 0.254777 0.3822 0.212314 0.150743 0.59448 0.40552 0.264331 0.232484 0.359873 0.143312 0.592357 0.407643 0.299363 0.280255 0.178344 0.242038 0.458599 0.541401 0.200637 0.633758 0.098726 0.066879 0.732484 0.267516 0.696941 33927.94 -0.34377 0.354633 0.571885 0.201278 0.089457 0.527157 0.472843 0.230032 0.127796 0.102236 9.056389 9.415335 NMV_0414 2191376 CDS -3 384969 386069 1101 validated/Curated no anmK anhydro-N-acetylmuramic acid kinase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.1.170 RXN0-4621 PWY0-1261 2018-01-17 16:11:49 no 15901686, 16452451 Catalyses the following reaction: ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O <=> ADP + N-acetylmuramate 6-phosphate. 2 vladimir 0.224638 0.3116 0.276268 0.1875 0.587862 0.412138 0.211957 0.277174 0.353261 0.157609 0.630435 0.369565 0.266304 0.255435 0.220109 0.258152 0.475543 0.524457 0.195652 0.402174 0.255435 0.146739 0.657609 0.342391 0.621608 39978.88 -0.124796 0.343324 0.520436 0.201635 0.117166 0.599455 0.400545 0.215259 0.111717 0.103542 5.723869 9.610354 NMV_0416 2191378 CDS +3 386394 387968 1575 validated/Curated no putative phosphate permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-31 12:29:54 no Potential transporter for phosphate. 2 vladimir 0.204444 0.2444 0.281905 0.269206 0.526349 0.473651 0.278095 0.135238 0.373333 0.213333 0.508571 0.491429 0.222857 0.241905 0.16381 0.371429 0.405714 0.594286 0.112381 0.35619 0.308571 0.222857 0.664762 0.335238 0.706552 56340.675 0.580344 0.337786 0.530534 0.259542 0.133588 0.673664 0.326336 0.146947 0.087786 0.05916 8.969978 8.784351 NMV_0417 2191379 CDS -2 388321 389742 1422 validated/Curated no hemN oxygen-independent coproporphyrinogen III oxidase (coproporphyrinogenase; coprogen oxidase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 1.3.98.3 HEMN-RXN HEMESYN2-PWY$PWY0-1415 2018-01-17 16:13:03 no Catalyses the following reaction during porphyrin biosynthesis: coproporphyrinogen-III + 2 S-adenosyl-L-methionine <=> protoporphyrinogen-IX + 2 CO(2) + 2 L-methionine + 2 5'-deoxyadenosine. 2 vladimir 0.256681 0.3228 0.220816 0.199719 0.543601 0.456399 0.272152 0.255274 0.303797 0.168776 0.559072 0.440928 0.348101 0.179325 0.179325 0.293249 0.35865 0.64135 0.149789 0.533755 0.179325 0.137131 0.71308 0.28692 0.711376 54282.03 -0.35518 0.243129 0.437632 0.221987 0.135307 0.53277 0.46723 0.291755 0.156448 0.135307 6.267326 9.617336 NMV_0418 2191380 CDS +2 389945 390679 735 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2008-02-13 16:28:11 no 1 vladimir 0.22449 0.2857 0.24898 0.240816 0.534694 0.465306 0.253061 0.265306 0.285714 0.195918 0.55102 0.44898 0.269388 0.17551 0.212245 0.342857 0.387755 0.612245 0.15102 0.416327 0.24898 0.183673 0.665306 0.334694 0.625287 27414.765 0.012295 0.29918 0.434426 0.245902 0.110656 0.528689 0.471311 0.258197 0.151639 0.106557 7.768669 9.192623 NMV_0419 2191381 CDS -3 390792 391742 951 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-17 16:13:33 no Contains one helix-turn-helix (HTH) LysR-type DNA-binding domain. 1 vladimir 0.240799 0.2534 0.270242 0.235542 0.523659 0.476341 0.25552 0.214511 0.347003 0.182965 0.561514 0.438486 0.305994 0.246057 0.14511 0.302839 0.391167 0.608833 0.160883 0.299685 0.318612 0.22082 0.618297 0.381703 0.6385 35140.975 -0.068671 0.275316 0.493671 0.253165 0.10443 0.563291 0.436709 0.25 0.126582 0.123418 5.69973 9.136076 NMV_0420 2191382 CDS +3 392106 392828 723 validated/Curated no rmpM outer membrane protein class 4 2b : Function from indirect experimental evidences (e.g. phenotypes) m : membrane component 7 : Outer membrane protein 2018-01-17 16:14:09 no Belongs to the OmpA family. 2 vladimir 0.261411 0.2739 0.251729 0.213001 0.525588 0.474412 0.211618 0.219917 0.419087 0.149378 0.639004 0.360996 0.3361 0.253112 0.157676 0.253112 0.410788 0.589212 0.236515 0.348548 0.178423 0.236515 0.526971 0.473029 0.787628 25971.235 -0.302083 0.3125 0.5625 0.220833 0.070833 0.525 0.475 0.25 0.133333 0.116667 6.59481 9.695833 NMNmiscRNA0174 54921366 misc_RNA +1 393237 393583 347 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:48:29 28334889 Function unknown. vladimir NMV_0421 2191383 CDS +1 393649 394605 957 validated/Curated no thiL thiamine-monophosphate kinase (thiamine-phosphate kinase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2.7.4.16 THI-P-KIN-RXN PWY-6894 2018-01-17 16:14:33 no Catalyses the following reaction where thiamine pyrophosphate (TPP; coenzyme B1) is an enzyme cofactor: ATP + thiamine phosphate <=> ADP + thiamine pyrophosphate. 1 vladimir 0.193312 0.2111 0.338558 0.257053 0.549634 0.450366 0.184953 0.178683 0.426332 0.210031 0.605016 0.394984 0.241379 0.213166 0.22884 0.316614 0.442006 0.557994 0.153605 0.241379 0.360502 0.244514 0.601881 0.398119 0.591842 34521.435 0.116667 0.311321 0.537736 0.248428 0.091195 0.622642 0.377358 0.27044 0.128931 0.141509 5.169731 9.261006 NMV_0422 2191384 CDS +2 394598 395083 486 validated/Curated no pgpA phosphatidylglycerophosphatase A 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.1 : Phospholipid ; 3.1.3.27 PGPPHOSPHA-RXN PWY-5269$PWY-5668$PWY4FS-7$PWY4FS-8 2018-01-17 16:14:55 no Catalyses the following reaction: phosphatidylglycerophosphate + H(2)O <=> phosphatidylglycerol + phosphate. 1 vladimir 0.135802 0.2016 0.327161 0.335391 0.528807 0.471193 0.185185 0.191358 0.364198 0.259259 0.555556 0.444444 0.12963 0.216049 0.203704 0.450617 0.419753 0.580247 0.092593 0.197531 0.41358 0.296296 0.611111 0.388889 0.642292 17773.72 1.104969 0.291925 0.47205 0.304348 0.173913 0.795031 0.204969 0.149068 0.074534 0.074534 5.526909 8.490683 NMV_0423 2191385 CDS -2 395143 396819 1677 validated/Curated no ettA energy-dependent translational throttle protein EttA 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2020-02-19 15:46:13 no 24389465 Translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation. 1 vladimir 0.255218 0.2439 0.29517 0.205725 0.539058 0.460942 0.22898 0.200358 0.404293 0.166369 0.604651 0.395349 0.347048 0.189624 0.186047 0.277281 0.375671 0.624329 0.189624 0.341682 0.29517 0.173524 0.636852 0.363148 0.751636 61951.915 -0.401792 0.267025 0.462366 0.222222 0.087814 0.537634 0.462366 0.304659 0.145161 0.159498 5.278572 9.311828 NMV_0424 2191386 CDS +3 397206 398561 1356 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 16:21:04 no Belongs to the major facilitator superfamily. 1 vladimir 0.185841 0.2485 0.292773 0.272861 0.541298 0.458702 0.243363 0.174779 0.336283 0.245575 0.511062 0.488938 0.210177 0.256637 0.163717 0.369469 0.420354 0.579646 0.103982 0.314159 0.378319 0.20354 0.692478 0.307522 0.690125 48990.49 0.643681 0.343681 0.514412 0.252772 0.16408 0.700665 0.299335 0.104213 0.064302 0.039911 8.685966 8.802661 NMV_0425 2191387 CDS +3 398565 399575 1011 validated/Curated no galM aldose 1-epimerase (mutarotase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.7.7 : Galactose metabolism ; 5.1.3.3 ALDOSE1EPIM-RXN PWY-6317 2018-01-17 16:21:51 no Catalyses the following reaction: alpha-D-glucose <=> beta-D-glucose. 1 vladimir 0.174085 0.3056 0.318497 0.20178 0.624135 0.375865 0.183976 0.249258 0.424332 0.142433 0.673591 0.32641 0.272997 0.249258 0.219585 0.25816 0.468843 0.531157 0.065282 0.418398 0.311573 0.204748 0.72997 0.27003 0.636447 36599.335 -0.292857 0.321429 0.583333 0.217262 0.098214 0.550595 0.449405 0.27381 0.133929 0.139881 5.31414 9.848214 NMV_0426 2191388 CDS +2 399809 402067 2259 validated/Curated no mdxK maltose phosphorylase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 4.S.113 : maltose ; 2.4.1.8 MALTOSE-PHOSPHORYLASE-RXN MALTOSECAT-PWY 2018-01-23 11:05:20 no Catalyses the following reaction: maltose + phosphate <=> D-glucose + beta-D-glucose 1-phosphate. 2 vladimir 0.255423 0.3015 0.255423 0.187694 0.556884 0.443116 0.247012 0.196547 0.366534 0.189907 0.563081 0.436919 0.347942 0.203187 0.180611 0.26826 0.383798 0.616202 0.171315 0.504648 0.219124 0.104914 0.723772 0.276228 0.784411 85312.765 -0.374335 0.275266 0.485372 0.200798 0.148936 0.542553 0.457447 0.263298 0.130319 0.132979 5.486107 9.634309 NMV_0427 2191389 CDS +2 402080 402745 666 validated/Curated no pgmB pgm beta-phosphoglucomutase (beta-PGM) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 4.S.113 : maltose ; 5.4.2.6 BETA-PHOSPHOGLUCOMUTASE-RXN MALTOSECAT-PWY$PWY-6317 2018-01-29 17:46:43 no Catalyses the following reaction: beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate. 2 vladimir 0.22973 0.3408 0.267267 0.162162 0.608108 0.391892 0.22973 0.193694 0.445946 0.130631 0.63964 0.36036 0.297297 0.261261 0.162162 0.279279 0.423423 0.576577 0.162162 0.567568 0.193694 0.076577 0.761261 0.238739 0.702132 23584.01 0.018552 0.339367 0.524887 0.230769 0.090498 0.606335 0.393665 0.266968 0.131222 0.135747 5.455025 9.067873 NMV_0428 2191390 CDS -1 402923 404431 1509 validated/Curated no nadB nicB L-aspartate oxidase (quinolinate synthase B protein; LASPO) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 1.4.3.16 L-ASPARTATE-OXID-RXN$RXN-9772 PYRIDNUCSYN-PWY 2018-01-17 17:20:42 no Catalyses the following reaction: L-aspartate + O(2) <=> iminosuccinate + H(2)O(2). L-aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD(+) in some bacteria. 2 vladimir 0.225977 0.3532 0.262425 0.158383 0.61564 0.384361 0.208748 0.292247 0.359841 0.139165 0.652087 0.347913 0.26839 0.266402 0.224652 0.240557 0.491054 0.508946 0.200795 0.500994 0.202783 0.095427 0.703777 0.296223 0.633741 54560.665 -0.204183 0.360558 0.523904 0.201195 0.087649 0.551793 0.448207 0.237052 0.133466 0.103586 6.678658 10.141434 NMV_0429 2191391 CDS -1 404480 404815 336 validated/Curated no putative small multidrug resistance protein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-27 18:11:11 no Belongs to the small multidrug resistance (Smr) protein family that confer resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. 1 vladimir 0.184524 0.1994 0.28869 0.327381 0.488095 0.511905 0.276786 0.151786 0.321429 0.25 0.473214 0.526786 0.116071 0.205357 0.214286 0.464286 0.419643 0.580357 0.160714 0.241071 0.330357 0.267857 0.571429 0.428571 0.604824 11852.8 1.237838 0.36036 0.522523 0.342342 0.135135 0.720721 0.279279 0.09009 0.063063 0.027027 8.038582 7.792793 NMV_0430 2191392 CDS -3 404967 406079 1113 validated/Curated no nicA quinolinate synthase A 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 2.5.1.72 QUINOLINATE-SYNTHA-RXN$QUINOLINATE-SYNTHE-MULTI-RXN PYRIDNUCSYN-PWY 2018-01-17 16:32:30 no Catalyses the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria: glycerone phosphate + iminosuccinate <=> pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate. 1 vladimir 0.22372 0.2642 0.315364 0.196765 0.579515 0.420485 0.218329 0.210243 0.398922 0.172507 0.609164 0.390836 0.293801 0.250674 0.177898 0.277628 0.428571 0.571429 0.15903 0.331536 0.369272 0.140162 0.700809 0.299191 0.686204 40190.665 -0.080811 0.321622 0.527027 0.218919 0.083784 0.581081 0.418919 0.264865 0.132432 0.132432 5.598793 9.410811 NMV_0431 2191393 CDS +3 406281 407219 939 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 6 : Inner membrane-associated 2018-01-17 16:33:24 no Might be implicated in nicotinic acid mononucleotide (NMN) biosynthesis based on the genomic context of the neighbouring genes (nicA and nadC). 2 vladimir 0.207668 0.3259 0.290735 0.175719 0.616613 0.383387 0.188498 0.329073 0.335463 0.146965 0.664537 0.335463 0.303514 0.204473 0.207668 0.284345 0.412141 0.587859 0.13099 0.444089 0.329073 0.095847 0.773163 0.226837 0.678312 35438.205 -0.360256 0.240385 0.464744 0.237179 0.102564 0.557692 0.442308 0.259615 0.137821 0.121795 6.437798 9.897436 NMV_0432 2191394 CDS +3 407295 408176 882 validated/Curated no nadC nicotinate-nucleotide pyrophosphorylase [carboxylating] (quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 2.4.2.19 QUINOPRIBOTRANS-RXN PYRIDNUCSYN-PWY 2018-01-17 16:35:24 no Is involved in the de novo biosynthesis of NAD(+) by catalysing the following reaction: beta-nicotinate D-ribonucleotide + diphosphate + CO(2) <=> pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. 2 vladimir 0.217687 0.3435 0.276644 0.162132 0.620181 0.379819 0.221088 0.221088 0.428571 0.129252 0.64966 0.35034 0.265306 0.261905 0.190476 0.282313 0.452381 0.547619 0.166667 0.547619 0.210884 0.07483 0.758503 0.241497 0.713221 31113.21 0.102048 0.365188 0.559727 0.245734 0.064846 0.580205 0.419795 0.238908 0.112628 0.12628 5.086632 9.658703 NMV_0433 2191395 CDS +3 408582 408863 282 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-17 16:35:39 no Belongs to the ArsR family of regulatory protein. 2 vladimir 0.255319 0.3050 0.237589 0.202128 0.542553 0.457447 0.297872 0.297872 0.276596 0.12766 0.574468 0.425532 0.265957 0.244681 0.148936 0.340426 0.393617 0.606383 0.202128 0.37234 0.287234 0.138298 0.659574 0.340426 0.60585 10541 0.024731 0.258065 0.408602 0.301075 0.075269 0.537634 0.462366 0.290323 0.182796 0.107527 9.802788 9.408602 NMV_0434 2191396 CDS +2 408923 409693 771 validated/Curated no xthA exodeoxyribonuclease III (exonuclease III; EXO III) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 3.1.11.2 3.1.11.2-RXN 2018-01-22 15:31:58 no Functions in DNA repair by catalysing exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. 1 vladimir 0.224384 0.2750 0.291829 0.20882 0.566796 0.433204 0.210117 0.264591 0.365759 0.159533 0.63035 0.36965 0.330739 0.198444 0.175097 0.29572 0.373541 0.626459 0.132296 0.361868 0.33463 0.171206 0.696498 0.303502 0.719925 29172.225 -0.250391 0.226562 0.5 0.234375 0.125 0.570312 0.429688 0.273438 0.136719 0.136719 5.517509 9.714844 NMV_0439 2191401 CDS +1 410701 410883 183 validated/Curated partial truncated IS110 family transposase (internal 4% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 12:36:48 no 1 vladimir 0.25969 0.2597 0.24031 0.24031 0.5 0.5 0.232558 0.325581 0.290698 0.151163 0.616279 0.383721 0.360465 0.162791 0.151163 0.325581 0.313953 0.686047 0.186047 0.290698 0.27907 0.244186 0.569767 0.430233 0.53861 9757.91 -0.111765 0.235294 0.4 0.282353 0.164706 0.541176 0.458824 0.294118 0.188235 0.105882 8.123711 8.847059 NMV_0440 2191402 CDS +2 411710 413068 1359 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 16:35:55 no 1 vladimir 0.219279 0.2421 0.290655 0.247976 0.532745 0.467255 0.247241 0.203091 0.362031 0.187638 0.565121 0.434879 0.275938 0.216336 0.1766 0.331126 0.392936 0.607064 0.134658 0.306843 0.333333 0.225166 0.640177 0.359823 0.536529 49140.365 0.04646 0.292035 0.524336 0.280973 0.075221 0.564159 0.435841 0.236726 0.117257 0.119469 5.50576 8.887168 NMV_0441 2191403 CDS +1 413065 413682 618 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-22 18:01:30 no 1 vladimir 0.247818 0.2112 0.273997 0.267016 0.485166 0.514834 0.267016 0.188482 0.324607 0.219895 0.513089 0.486911 0.298429 0.193717 0.193717 0.314136 0.387435 0.612565 0.17801 0.251309 0.303665 0.267016 0.554974 0.445026 0.520058 21075.445 -0.113684 0.284211 0.505263 0.273684 0.094737 0.526316 0.473684 0.289474 0.157895 0.131579 6.899437 8.484211 NMV_0442 2191404 CDS +1 413860 414213 354 validated/Curated partial truncated IS110 family transposase (C-terminal third of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-02-13 16:36:21 no 1 vladimir 0.231638 0.2542 0.30791 0.206215 0.562147 0.437853 0.279661 0.228814 0.338983 0.152542 0.567797 0.432203 0.254237 0.279661 0.220339 0.245763 0.5 0.5 0.161017 0.254237 0.364407 0.220339 0.618644 0.381356 0.550352 13064.64 -0.400855 0.333333 0.495726 0.162393 0.094017 0.547009 0.452991 0.290598 0.188034 0.102564 9.936836 10.384615 NMV_0443 2191405 CDS -2 415213 418818 3606 validated/Curated no putA bifunctional PutA protein [includes: proline dehydrogenase (proline oxidase) and delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase)] 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.1.3.6 : Proline utilization ; 1.5.5.2, 1.2.1.88 PYRROLINECARBDEHYDROG-RXN$RXN-821 PROUT-PWY 2018-01-29 18:13:28 no Oxidizes proline to glutamate in two steps for use as a carbon and nitrogen sources. Also functions as a transcriptional repressor of the put operon. 2 vladimir 0.237937 0.3367 0.251803 0.1736 0.588464 0.411536 0.230449 0.24376 0.398502 0.127288 0.642263 0.357737 0.299501 0.242928 0.178037 0.279534 0.420965 0.579035 0.18386 0.523295 0.178869 0.113977 0.702163 0.297837 0.774297 130106.74 -0.101998 0.319734 0.527893 0.232306 0.087427 0.568693 0.431307 0.240633 0.125729 0.114904 5.991753 9.557868 NMV_0444 2191406 CDS -3 419067 420593 1527 validated/Curated no putP sodium/proline symporter (proline permease) 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 2008-02-13 16:36:51 no 2 vladimir 0.176817 0.2646 0.290766 0.267845 0.555337 0.444663 0.235756 0.157171 0.367387 0.239686 0.524558 0.475442 0.172888 0.267191 0.192534 0.367387 0.459725 0.540275 0.121807 0.369352 0.312377 0.196464 0.681729 0.318271 0.751308 54254.585 0.780512 0.377953 0.521654 0.271654 0.135827 0.716535 0.283465 0.114173 0.064961 0.049213 8.475548 8.820866 NMV_0446 2191408 CDS +1 421078 421398 321 validated/Curated no putative ubiquinone biosynthesis accessory factor UbiK 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2020-02-19 15:55:37 no Is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. 2 vladimir 0.302181 0.2430 0.280374 0.174455 0.523364 0.476636 0.271028 0.168224 0.457944 0.102804 0.626168 0.373832 0.373832 0.252336 0.11215 0.261682 0.364486 0.635514 0.261682 0.308411 0.271028 0.158879 0.579439 0.420561 0.747404 11587.695 -0.337736 0.301887 0.443396 0.198113 0.037736 0.509434 0.490566 0.301887 0.122642 0.179245 4.739174 9.764151 NMV_0447 2191409 CDS +2 421412 422908 1497 validated/Curated no putative Mg chelatase-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2020-02-19 16:49:37 no Belongs to a family of bacterial proteins that are a subset of the magnesium chelatase ChlI subunit family and either belong, or show significant homology, to the non-peptidase homologs of the MEROPS peptidase family S16 (Lon protease family, clan SF). 2 vladimir 0.204409 0.3100 0.287241 0.198397 0.597194 0.402806 0.182365 0.274549 0.390782 0.152305 0.665331 0.334669 0.258517 0.256513 0.204409 0.280561 0.460922 0.539078 0.172345 0.398798 0.266533 0.162325 0.665331 0.334669 0.705731 53475.355 -0.096386 0.319277 0.508032 0.228916 0.074297 0.592369 0.407631 0.248996 0.136546 0.11245 6.499962 9.487952 NMV_0448 2191410 CDS +2 423014 423877 864 validated/Curated no putative FtsN-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2020-02-22 16:41:28 no 1 vladimir 0.341379 0.2276 0.272414 0.158621 0.5 0.5 0.303448 0.196552 0.393103 0.106897 0.589655 0.410345 0.434483 0.255172 0.110345 0.2 0.365517 0.634483 0.286207 0.231034 0.313793 0.168966 0.544828 0.455172 0.658426 31878.84 -0.881661 0.283737 0.456747 0.155709 0.051903 0.442907 0.557093 0.356401 0.190311 0.16609 8.840202 8.809689 NMV_0449 2191411 CDS +1 423880 424524 645 validated/Curated no dsbA3 thiol:disulfide interchange protein DsbA3 1a : Function from experimental evidences in the studied strain e : enzyme 9 : Periplasmic 2008-02-13 16:37:58 no 15105427 1 vladimir 0.260465 0.2264 0.263566 0.249612 0.489922 0.510078 0.227907 0.204651 0.35814 0.209302 0.562791 0.437209 0.344186 0.223256 0.134884 0.297674 0.35814 0.64186 0.209302 0.251163 0.297674 0.24186 0.548837 0.451163 0.661434 23963.015 -0.17243 0.252336 0.443925 0.238318 0.116822 0.588785 0.411215 0.271028 0.168224 0.102804 9.377357 9.154206 NMV_0450 2191412 CDS +3 424557 425378 822 validated/Curated no uppP undecaprenyl-diphosphatase (undecaprenyl pyrophosphate phosphatase; bacitracin resistance protein) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.6.7 : Peptidoglycan (murein) ; 3.6.1.27 UNDECAPRENYL-DIPHOSPHATASE-RXN 2018-01-17 17:30:13 no Catalyses the following reaction: undecaprenyl diphosphate + H(2)O <=> undecaprenyl phosphate + phosphate. 1 vladimir 0.20073 0.1934 0.274939 0.3309 0.46837 0.53163 0.255474 0.171533 0.350365 0.222628 0.521898 0.478102 0.20438 0.182482 0.171533 0.441606 0.354015 0.645985 0.142336 0.226277 0.30292 0.328467 0.529197 0.470803 0.653382 30374.03 0.769231 0.260073 0.450549 0.315018 0.157509 0.692308 0.307692 0.18315 0.117216 0.065934 9.659767 8.516484 NMV_tRNA_57 2194872 tRNA -1 425669 425744 76 validated/Curated no Ala tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:49:54 no tRNA Ala anticodon GGC. vladimir NMV_tRNA_56 2194871 tRNA -1 425752 425828 77 validated/Curated no Met tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:50:04 no tRNA Met anticodon CAT. vladimir NMV_0451 2191413 CDS -1 425960 427108 1149 validated/Curated no putative methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-22 18:05:42 no 2 vladimir 0.262726 0.2906 0.208539 0.238095 0.499179 0.500821 0.241379 0.26601 0.307882 0.184729 0.573892 0.426108 0.307882 0.248768 0.147783 0.295566 0.396552 0.603448 0.238916 0.357143 0.169951 0.23399 0.527094 0.472906 0.58261 44674.27 -0.052099 0.301235 0.471605 0.22963 0.138272 0.587654 0.412346 0.204938 0.111111 0.093827 5.955971 9.08642 NMV_0452 2191414 CDS +1 427456 427911 456 validated/Curated no putative transcriptional regulator MraZ 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-23 15:12:52 no 1 vladimir 0.20614 0.2171 0.317982 0.258772 0.535088 0.464912 0.171053 0.25 0.394737 0.184211 0.644737 0.355263 0.309211 0.171053 0.184211 0.335526 0.355263 0.644737 0.138158 0.230263 0.375 0.256579 0.605263 0.394737 0.560955 17197.17 -0.137086 0.205298 0.443709 0.284768 0.092715 0.569536 0.430464 0.298013 0.145695 0.152318 5.413155 9.450331 NMV_0453 2191415 CDS +3 427908 428894 987 validated/Curated no rsmH mraW ribosomal RNA small subunit methyltransferase H 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.199 RXN-11638 2018-01-17 17:35:48 no Catalyses the following reaction: S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA <=> S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. Is necessary for efficient translation initiation at the UUG and GUG codons. 1 vladimir 0.203647 0.2300 0.345491 0.220871 0.575481 0.424519 0.200608 0.224924 0.422492 0.151976 0.647416 0.352584 0.264438 0.234043 0.221885 0.279635 0.455927 0.544073 0.145897 0.231003 0.392097 0.231003 0.6231 0.3769 0.56746 36073.675 -0.252744 0.301829 0.503049 0.22561 0.079268 0.54878 0.45122 0.292683 0.158537 0.134146 8.682121 9.72561 NMV_0454 2191416 CDS +2 428891 429154 264 validated/Curated no ftsL cell division protein FtsL 2a : Function from experimental evidences in other organisms f : factor 9 : Periplasmic 5.1 : Cell division ; 2020-04-20 17:59:11 no Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. 1 vladimir 0.277778 0.2370 0.266667 0.218519 0.503704 0.496296 0.277778 0.255556 0.3 0.166667 0.555556 0.444444 0.377778 0.233333 0.077778 0.311111 0.311111 0.688889 0.177778 0.222222 0.422222 0.177778 0.644444 0.355556 0.571133 10127.35 -0.198876 0.235955 0.426966 0.213483 0.101124 0.539326 0.460674 0.213483 0.146067 0.067416 9.651863 9.910112 NMV_0455 2191417 CDS +2 429215 430960 1746 validated/Curated no penA ftsI peptidoglycan D,D-transpeptidase PenA (penicillin-binding protein 2; PBP-2) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.7 : Peptidoglycan (murein) ; 3.4.16.4 3.4.16.4-RXN$RXN-11065$RXN-11302$RXN-11351 PEPTIDOGLYCANSYN-PWY 2018-01-22 16:07:39 no Catalyses cross-linking of the peptidoglycan cell wall at the division septum. Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 1 vladimir 0.241695 0.2600 0.289233 0.209049 0.549255 0.450745 0.266323 0.21134 0.369416 0.152921 0.580756 0.419244 0.298969 0.243986 0.175258 0.281787 0.419244 0.580756 0.159794 0.324742 0.323024 0.19244 0.647766 0.352234 0.648337 63601.44 -0.28296 0.292599 0.516351 0.222031 0.086059 0.554217 0.445783 0.259897 0.148021 0.111876 9.342964 9.378657 NMV_0456 2191418 CDS +2 430985 432463 1479 validated/Curated no murE UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (UDP-N-acetylmuramyl-tripeptide synthetase; meso-diaminopimelate-adding enzyme; UDP-MurNAc-tripeptide synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 6.3.2.13 UDP-NACMURALGLDAPLIG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2018-02-09 15:27:45 no Catalyses the following reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino-heptanedioate. 1 vladimir 0.23597 0.2941 0.261663 0.208249 0.555781 0.444219 0.231237 0.204868 0.399594 0.1643 0.604462 0.395538 0.296146 0.243408 0.200811 0.259635 0.444219 0.555781 0.180527 0.434077 0.184584 0.200811 0.618661 0.381339 0.748303 53239.185 -0.135569 0.335366 0.560976 0.213415 0.105691 0.583333 0.416667 0.235772 0.123984 0.111789 6.027107 9.593496 NMV_0457 2191419 CDS +3 432486 434135 1650 validated/Curated no putative phosphoethanolamine transferase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2018-01-27 18:14:59 no 1 vladimir 0.242424 0.2133 0.267273 0.27697 0.480606 0.519394 0.249091 0.174545 0.32 0.256364 0.494545 0.505455 0.289091 0.227273 0.196364 0.287273 0.423636 0.576364 0.189091 0.238182 0.285455 0.287273 0.523636 0.476364 0.584593 61054.6 -0.104554 0.309654 0.506375 0.224044 0.140255 0.586521 0.413479 0.216758 0.129326 0.087432 9.146111 9.029144 NMV_0458 2191420 CDS +1 434260 435618 1359 validated/Curated no murF UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase; D-alanyl-D-alanine-adding enzyme) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 6.3.2.10 UDP-NACMURALGLDAPAALIG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2018-01-17 17:43:34 no Catalyses the final step in the synthesis of the cytoplasmic precursor of the bacterial cell wall peptidoglycan. 1 vladimir 0.220015 0.2509 0.309787 0.219279 0.560706 0.439294 0.229581 0.15894 0.456954 0.154525 0.615894 0.384106 0.282561 0.236203 0.172185 0.309051 0.408389 0.591611 0.147903 0.357616 0.300221 0.19426 0.657837 0.342163 0.737291 48158.035 0.085177 0.318584 0.570796 0.230088 0.081858 0.608407 0.391593 0.25 0.117257 0.132743 5.065697 9.685841 NMV_0459 2191421 CDS +3 435621 435797 177 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-02-13 16:42:15 no 1 vladimir 0.231638 0.1864 0.282486 0.299435 0.468927 0.531073 0.220339 0.169492 0.338983 0.271186 0.508475 0.491525 0.271186 0.186441 0.220339 0.322034 0.40678 0.59322 0.20339 0.20339 0.288136 0.305085 0.491525 0.508475 0.573841 6369.315 0.310345 0.310345 0.465517 0.241379 0.12069 0.706897 0.293103 0.189655 0.12069 0.068966 9.103813 9.465517 NMV_0460 2191422 CDS +3 436044 437126 1083 validated/Curated no mraY phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP-MurNAc-pentapeptide phosphotransferase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.7 : Peptidoglycan (murein) ; 2.7.8.13 PHOSNACMURPENTATRANS-RXN PEPTIDOGLYCANSYN-PWY 2018-01-17 17:44:23 no Is responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. 2 vladimir 0.192059 0.2973 0.250231 0.260388 0.547553 0.452447 0.246537 0.182825 0.34349 0.227147 0.526316 0.473684 0.193906 0.238227 0.171745 0.396122 0.409972 0.590028 0.135734 0.470914 0.235457 0.157895 0.706371 0.293629 0.710069 39296.035 0.791111 0.319444 0.513889 0.305556 0.147222 0.708333 0.291667 0.113889 0.080556 0.033333 9.553703 8.758333 NMV_0461 2191423 CDS +3 437241 437621 381 validated/Curated no conserved hypothetical TPR-containing periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-17 17:45:03 no Contains tetratrico peptide repeat (TPR) structural motifs, which mediate protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.270341 0.2310 0.309711 0.188976 0.540682 0.459318 0.15748 0.212598 0.440945 0.188976 0.653543 0.346457 0.377953 0.204724 0.212598 0.204724 0.417323 0.582677 0.275591 0.275591 0.275591 0.173228 0.551181 0.448819 0.643582 13903.965 -0.428571 0.325397 0.5 0.15873 0.119048 0.603175 0.396825 0.206349 0.111111 0.095238 7.945976 10.428571 NMV_0462 2191424 CDS +3 437706 439043 1338 validated/Curated no murD UDP-N-acetylmuramoylalanine-D-glutamate ligase (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; D-glutamic acid adding enzyme) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 6.3.2.9 UDP-NACMURALA-GLU-LIG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2020-04-21 14:33:48 no Is involved, together with the other Mur synthetases (MurC, MurD, MurE, and MurF), in the assembly of the peptide moiety of the monomer unit of bacterial peptidoglycan. 1 vladimir 0.230942 0.2571 0.30568 0.206278 0.56278 0.43722 0.248879 0.190583 0.412556 0.147982 0.603139 0.396861 0.304933 0.199552 0.197309 0.298206 0.396861 0.603139 0.139013 0.381166 0.307175 0.172646 0.688341 0.311659 0.699922 48231.16 -0.071685 0.310112 0.521348 0.238202 0.085393 0.575281 0.424719 0.262921 0.12809 0.134831 5.372566 9.280899 NMV_0463 2191425 CDS +2 439169 440494 1326 validated/Curated no ftsW peptidoglycan glycosyltransferase FtsW 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 5.1 : Cell division ; 2.4.1.129 2.4.1.129-RXN$RXN-11291$RXN-11301$RXN-11348$RXN-11350$RXN0-5405 PEPTIDOGLYCANSYN-PWY$PWY-6385 2018-01-17 17:46:49 no Peptidoglycan polymerase that is essential for cell division. 1 vladimir 0.172783 0.2194 0.313456 0.294343 0.532875 0.467125 0.238532 0.199541 0.321101 0.240826 0.520642 0.479358 0.167431 0.183486 0.224771 0.424312 0.408257 0.591743 0.112385 0.275229 0.394495 0.21789 0.669725 0.330275 0.632778 48710.23 0.669195 0.278161 0.445977 0.301149 0.142529 0.701149 0.298851 0.158621 0.098851 0.05977 9.865486 9.013793 NMV_0464 2191426 CDS +2 440498 441565 1068 validated/Curated no murG UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) 2a : Function from experimental evidences in other organisms e : enzyme 6 : Inner membrane-associated 1.6.7 : Peptidoglycan (murein) ; 2.4.1.227 NACGLCTRANS-RXN PEPTIDOGLYCANSYN-PWY 2018-01-17 17:50:15 no Is responsible for the final step in the formation of the lipid-linked disaccharide-pentapeptide subunit of peptidoglycan. The enzyme is peripherally associated with the inner-face of the cytoplasmic membrane. Therefore, the peptidoglycan subunit is completely assembled before it traverses the cytoplasmic membrane. 1 vladimir 0.194757 0.2715 0.326779 0.206929 0.598315 0.401685 0.202247 0.235955 0.401685 0.160112 0.63764 0.36236 0.252809 0.235955 0.210674 0.300562 0.446629 0.553371 0.129213 0.342697 0.367978 0.160112 0.710674 0.289326 0.700749 38097.63 0.092958 0.326761 0.515493 0.247887 0.090141 0.625352 0.374648 0.230986 0.140845 0.090141 9.190651 9.538028 NMV_0465 2191427 CDS +3 441720 443129 1410 validated/Curated no murC UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 6.3.2.8 UDP-NACMUR-ALA-LIG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2020-02-19 16:53:59 no Is involved in peptidoglycan biosynthetis by catalysing the following reaction: ATP + UDP-N-acetylmuramate + L-alanine <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. 2 vladimir 0.224823 0.2950 0.268794 0.211348 0.56383 0.43617 0.246809 0.197872 0.419149 0.13617 0.617021 0.382979 0.291489 0.238298 0.157447 0.312766 0.395745 0.604255 0.13617 0.448936 0.229787 0.185106 0.678723 0.321277 0.74803 50318.55 0.07548 0.313433 0.537313 0.249467 0.100213 0.597015 0.402985 0.238806 0.123667 0.115139 5.691826 9.530917 NMV_0466 2191428 CDS +1 443242 444156 915 validated/Curated no ddl D-alanine-D-alanine ligase (D-alanylalanine synthetase; D-Ala-D-Ala ligase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 6.3.2.4 DALADALALIG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2018-01-17 17:51:22 no Is involved in cell-wall biosynthesis by catalysing the following reaction: ATP + 2 D-alanine <=> ADP + phosphate + D-alanyl-D-alanine. 2 vladimir 0.255738 0.2536 0.273224 0.217486 0.526776 0.473224 0.242623 0.167213 0.416393 0.17377 0.583607 0.416393 0.308197 0.206557 0.193443 0.291803 0.4 0.6 0.216393 0.386885 0.209836 0.186885 0.596721 0.403279 0.728004 32552.875 -0.006908 0.328947 0.516447 0.233553 0.098684 0.601974 0.398026 0.25 0.111842 0.138158 4.914131 9.085526 NMV_0467 2191429 CDS +2 444146 444874 729 validated/Curated no ftsQ cell division protein FtsQ 2b : Function from indirect experimental evidences (e.g. phenotypes) m : membrane component 11 : Membrane 5.1 : Cell division ; 2018-01-17 17:52:04 no Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. 1 vladimir 0.230453 0.2277 0.305898 0.23594 0.533608 0.466392 0.238683 0.201646 0.36214 0.197531 0.563786 0.436214 0.304527 0.201646 0.201646 0.292181 0.403292 0.596708 0.148148 0.279835 0.353909 0.218107 0.633745 0.366255 0.558707 27922.045 -0.398347 0.247934 0.454545 0.219008 0.115702 0.545455 0.454545 0.297521 0.169421 0.128099 9.43856 10.260331 NMV_0468 2191430 CDS +3 444960 446204 1245 validated/Curated no ftsA cell division protein FtsA 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 5.1 : Cell division ; 2018-03-22 18:07:41 no Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. 1 vladimir 0.254618 0.2386 0.290763 0.216064 0.529317 0.470683 0.298795 0.187952 0.40241 0.110843 0.590361 0.409639 0.279518 0.212048 0.19759 0.310843 0.409639 0.590361 0.185542 0.315663 0.272289 0.226506 0.587952 0.412048 0.655717 44100.735 0.019565 0.318841 0.538647 0.272947 0.043478 0.562802 0.437198 0.2343 0.113527 0.120773 5.330162 9.294686 NMV_0469 2191431 CDS +1 446323 447501 1179 validated/Curated no ftsZ cell division protein FtsZ 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 5.1 : Cell division ; 2018-01-17 17:53:47 no Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. 1 vladimir 0.242578 0.2485 0.291773 0.217133 0.540288 0.459712 0.290076 0.160305 0.437659 0.111959 0.597964 0.402036 0.279898 0.251908 0.175573 0.292621 0.427481 0.572519 0.157761 0.333333 0.262087 0.246819 0.59542 0.40458 0.741771 41485.385 -0.023724 0.341837 0.576531 0.229592 0.048469 0.561224 0.438776 0.242347 0.109694 0.132653 4.939339 9.808673 NMV_0470 2191432 CDS +1 447640 448950 1311 validated/Curated no putative permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 17:54:11 no Belongs to the xanthine/uracil/vitamin C group of permeases from the major facilitator superfamily. 1 vladimir 0.177727 0.2479 0.28299 0.291381 0.530892 0.469108 0.2746 0.155606 0.370709 0.199085 0.526316 0.473684 0.139588 0.26087 0.173913 0.425629 0.434783 0.565217 0.118993 0.327231 0.304348 0.249428 0.631579 0.368421 0.696092 46065.215 1.00367 0.355505 0.548165 0.302752 0.112385 0.727064 0.272936 0.116972 0.06422 0.052752 7.781593 8.649083 NMV_0472 2191434 CDS +1 449575 450450 876 validated/Curated no prpB 2-methylisocitrate lyase (methylisocitrate lyase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.2.3 : Propionate degradation ; 4.1.3.30 METHYLISOCITRATE-LYASE-RXN 2018-01-17 17:55:16 no Acts in propionate metabolism by catalysing the following reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate. 1 vladimir 0.230944 0.2537 0.281001 0.234357 0.534699 0.465301 0.228669 0.197952 0.430034 0.143345 0.627986 0.372014 0.290102 0.255973 0.163823 0.290102 0.419795 0.580205 0.174061 0.307167 0.249147 0.269625 0.556314 0.443686 0.769473 31712.865 0.007192 0.325342 0.55137 0.215753 0.089041 0.582192 0.417808 0.243151 0.116438 0.126712 5.221001 9.976027 NMV_0473 2191435 CDS +2 450536 451690 1155 validated/Curated no prpC 2-methylcitrate synthase (methylcitrate synthase; citrate synthase 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.1.2.3 : Propionate degradation ; 2.3.3.5 2-METHYLCITRATE-SYNTHASE-RXN$CITSYN-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-17 17:55:50 no Is associated with propionate metabolism by catalysing the following reaction: propanoyl-CoA + H(2)O + oxaloacetate <=> (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA. 2 vladimir 0.260606 0.2771 0.245887 0.21645 0.522944 0.477056 0.275325 0.220779 0.350649 0.153247 0.571429 0.428571 0.311688 0.220779 0.192208 0.275325 0.412987 0.587013 0.194805 0.38961 0.194805 0.220779 0.584416 0.415584 0.808273 42851.325 -0.314844 0.296875 0.473958 0.213542 0.119792 0.53125 0.46875 0.294271 0.164062 0.130208 6.636467 9.434896 NMV_0474 2191436 CDS +3 452016 452960 945 validated/Curated no putative fatty acid desaturase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 1.14.19.1-RXN$RXN-11680$RXN-12776 2018-01-17 17:56:32 no Belongs to the family 2 of the desaturases, which catalyse the insertion of a double bond at the delta position of fatty acids. 3 vladimir 0.339623 0.1153 0.165618 0.379455 0.280922 0.719078 0.320755 0.128931 0.194969 0.355346 0.323899 0.676101 0.358491 0.163522 0.128931 0.349057 0.292453 0.707547 0.339623 0.053459 0.172956 0.433962 0.226415 0.773585 0.412733 38127.99 -0.030599 0.201893 0.340694 0.242902 0.242902 0.574132 0.425868 0.239748 0.157729 0.082019 9.173241 8.419558 NMV_0475 2191437 CDS +1 452947 453858 912 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 17:56:53 no Belongs to the EamA transporter family. 3 vladimir 0.226974 0.1645 0.25 0.358553 0.414474 0.585526 0.266447 0.121711 0.309211 0.302632 0.430921 0.569079 0.174342 0.220395 0.164474 0.440789 0.384868 0.615132 0.240132 0.151316 0.276316 0.332237 0.427632 0.572368 0.561973 32888.19 1.035974 0.316832 0.448845 0.346535 0.122112 0.712871 0.287129 0.132013 0.072607 0.059406 8.302513 7.993399 NMV_0476 2191438 CDS +1 453949 456555 2607 validated/Curated no acnA aconitate hydratase 1 (citrate hydro-lyase 1; aconitase 1) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 4.2.1.3 ACONITATEDEHYDR-RXN$ACONITATEHYDR-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:25:14 no Catalyses the second and third reactions in the TCA cycle: citrate <=> cis-aconitate + H(2)O <=> isocitrate. 1 vladimir 0.235136 0.2865 0.276563 0.201764 0.563099 0.436901 0.239356 0.212888 0.397008 0.150748 0.609896 0.390104 0.293441 0.254315 0.179517 0.272727 0.433832 0.566168 0.172612 0.392405 0.253165 0.181818 0.64557 0.35443 0.74814 95170.615 -0.219931 0.300691 0.540323 0.214286 0.092166 0.572581 0.427419 0.256912 0.125576 0.131336 5.409737 9.861751 NMV_0477 2191439 CDS +1 456907 458076 1170 validated/Curated no prpF 2-methyl-aconitate isomerase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.2.1 : Degradation of short-chain fatty acids ; 5.3.3.- RXN-8977 2018-03-22 18:10:13 no 14702315, 17567742 Catalyses the following reaction: 2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate. Involved in the catabolism of short chain fatty acids via the 2-methylcitrate cycle II. 1 vladimir 0.234188 0.2880 0.283761 0.194017 0.571795 0.428205 0.261538 0.166667 0.435897 0.135897 0.602564 0.397436 0.271795 0.264103 0.192308 0.271795 0.45641 0.54359 0.169231 0.433333 0.223077 0.174359 0.65641 0.34359 0.712109 40949.88 -0.021851 0.359897 0.59126 0.210797 0.079692 0.596401 0.403599 0.233933 0.115681 0.118252 5.492302 9.228792 NMV_0478 2191440 CDS +3 458490 459689 1200 validated/Curated no ackA2 acetate kinase 2 (acetokinase 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.3.5 : Fermentation ; 2.7.2.1 ACETATEKIN-RXN$RXN-7958 FERMENTATION-PWY$PWY-5482$PWY-5485$PWY0-1312 2018-01-29 22:31:14 no Catalyses the following reaction: ATP + acetate <=> ADP + acetyl phosphate. 2 vladimir 0.2325 0.3117 0.248333 0.2075 0.56 0.44 0.275 0.2125 0.37 0.1425 0.5825 0.4175 0.28 0.225 0.2025 0.2925 0.4275 0.5725 0.1425 0.4975 0.1725 0.1875 0.67 0.33 0.746244 42793.35 -0.034085 0.33584 0.536341 0.235589 0.082707 0.578947 0.421053 0.240602 0.130326 0.110276 6.246498 9.556391 NMV_0479 2191441 CDS +2 459797 460417 621 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-22 18:10:44 no 1 vladimir 0.222222 0.2802 0.286634 0.21095 0.566828 0.433172 0.241546 0.246377 0.362319 0.149758 0.608696 0.391304 0.294686 0.231884 0.178744 0.294686 0.410628 0.589372 0.130435 0.362319 0.318841 0.188406 0.681159 0.318841 0.662816 22611.275 -0.081068 0.291262 0.504854 0.247573 0.07767 0.582524 0.417476 0.262136 0.126214 0.135922 5.246422 9.728155 NMV_0480 2191442 CDS -2 460579 461022 444 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2008-02-13 16:48:14 no 2 vladimir 0.227477 0.3086 0.252252 0.211712 0.560811 0.439189 0.290541 0.27027 0.297297 0.141892 0.567568 0.432432 0.263514 0.209459 0.182432 0.344595 0.391892 0.608108 0.128378 0.445946 0.277027 0.148649 0.722973 0.277027 0.610968 16098.19 0.22517 0.29932 0.510204 0.285714 0.102041 0.612245 0.387755 0.190476 0.115646 0.07483 8.492424 9.251701 NMV_0481 2191443 CDS +3 461196 461564 369 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 16:48:25 no 2 vladimir 0.235772 0.3062 0.260163 0.197832 0.566396 0.433604 0.162602 0.349593 0.317073 0.170732 0.666667 0.333333 0.333333 0.268293 0.162602 0.235772 0.430894 0.569106 0.211382 0.300813 0.300813 0.186992 0.601626 0.398374 0.610473 14399.895 -0.788525 0.221311 0.377049 0.147541 0.163934 0.491803 0.508197 0.385246 0.221311 0.163934 6.539803 10.352459 NMV_0482 2191444 CDS +2 461609 462763 1155 validated/Curated no putative NnrS-like protein 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2018-01-17 18:00:43 no NnrS is a haem- and copper-containing membrane protein. 1 vladimir 0.135065 0.2623 0.318615 0.283983 0.580952 0.419048 0.2 0.223377 0.335065 0.241558 0.558442 0.441558 0.14026 0.277922 0.207792 0.374026 0.485714 0.514286 0.064935 0.285714 0.412987 0.236364 0.698701 0.301299 0.641131 41734.885 0.760677 0.348958 0.515625 0.270833 0.179688 0.75 0.25 0.098958 0.088542 0.010417 10.361839 8.833333 NMV_0483 2191445 CDS -2 462820 463692 873 validated/Curated no putative prephenate dehydrogenase (PDH) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.1.14 : Tyrosine ; 1.3.1.12 PREPHENATE-DEHYDROGENASE-NADP+-RXN$PREPHENATEDEHYDROG-RXN TYRSYN 2020-02-19 17:23:31 no Possibly involved in tyrosine biosynthesis by catalysing the following reaction: prephenate + NAD(+) <=> 4-hydroxyphenylpyruvate + CO(2) + NADH. 2 vladimir 0.201604 0.3414 0.261168 0.195876 0.60252 0.39748 0.213058 0.257732 0.388316 0.140893 0.646048 0.353952 0.264605 0.247423 0.189003 0.298969 0.436426 0.563574 0.127148 0.5189 0.206186 0.147766 0.725086 0.274914 0.699819 31659.845 0.042069 0.313793 0.52069 0.258621 0.117241 0.57931 0.42069 0.268966 0.144828 0.124138 5.88932 9.175862 NMV_0484 2191446 CDS +1 463777 464589 813 validated/Curated no putative hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.5.-.- 2018-01-23 13:50:02 no Contains a carbon-nitrogen hydrolase domain found in numerous enzymes involved in the reduction of organic nitrogen compounds and ammonia production. 1 vladimir 0.193112 0.2718 0.335793 0.199262 0.607626 0.392374 0.180812 0.225092 0.439114 0.154982 0.664207 0.335793 0.254613 0.225092 0.217712 0.302583 0.442804 0.557196 0.143911 0.365314 0.350554 0.140221 0.715867 0.284133 0.660745 29303.415 0.007778 0.311111 0.551852 0.237037 0.103704 0.618519 0.381481 0.244444 0.12963 0.114815 6.188927 10.007407 NMV_0485 2191447 fCDS -3 465615 466298 684 validated/Curated pseudo opaA opacity protein A (pseudogene part 2) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-17 18:02:16 no Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. 2 vladimir 0.299708 0.2734 0.223684 0.203216 0.497076 0.502924 0.324561 0.166667 0.311404 0.197368 0.47807 0.52193 0.364035 0.22807 0.184211 0.223684 0.412281 0.587719 0.210526 0.425439 0.175439 0.188596 0.600877 0.399123 0.627848 25670.77 -0.636123 0.303965 0.519824 0.176211 0.171806 0.484581 0.515419 0.281938 0.189427 0.092511 9.589912 9.330396 NMV_0485.1 2598877 fCDS -1 466301 466420 120 validated/Curated pseudo opaA opacity protein A (pseudogene part 1) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-17 18:02:29 Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. vladimir NMV_0486 2191448 CDS -3 467196 468161 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-17 18:02:40 no Belongs to the IS30 family. 2 vladimir 0.325052 0.3064 0.204969 0.163561 0.511387 0.488613 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.381988 0.173913 0.226708 0.217391 0.400621 0.599379 0.248447 0.450311 0.173913 0.127329 0.624224 0.375776 0.57221 38033.15 -0.918069 0.249221 0.392523 0.193146 0.130841 0.417445 0.582555 0.330218 0.239875 0.090343 10.162636 9.744548 NMV_0488 2191450 CDS +2 469721 470575 855 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 18:02:55 no Belongs to the EamA transporter family. 2 vladimir 0.139181 0.2678 0.318129 0.274854 0.585965 0.414035 0.168421 0.214035 0.378947 0.238596 0.592982 0.407018 0.150877 0.249123 0.203509 0.396491 0.452632 0.547368 0.098246 0.340351 0.37193 0.189474 0.712281 0.287719 0.675977 30246.905 0.984155 0.348592 0.521127 0.320423 0.130282 0.760563 0.239437 0.116197 0.077465 0.038732 9.068672 8.714789 NMV_0489 2191451 CDS +2 471095 472327 1233 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-17 18:03:13 no Belongs to the drug resistance transporter Bcr/CflA subfamily. 1 vladimir 0.161395 0.2758 0.305758 0.257096 0.581509 0.418491 0.206813 0.214112 0.36253 0.216545 0.576642 0.423358 0.187348 0.255474 0.167883 0.389294 0.423358 0.576642 0.090024 0.357664 0.386861 0.16545 0.744526 0.255474 0.661986 44232.505 0.742927 0.343902 0.509756 0.260976 0.141463 0.709756 0.290244 0.114634 0.073171 0.041463 9.044426 9.009756 NMV_0490 2191452 CDS +1 472405 473493 1089 validated/Curated no pheA bifunctional chorismate mutase/prephenate dehydratase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.1.13 : Phenylalanine ; 1.5.1.14 : Tyrosine ; 4.2.1.51, 5.4.99.5 CHORISMATEMUT-RXN$PREPHENATEDEHYDRAT-RXN PHESYN$TYRSYN 2020-04-21 14:38:00 no This bifunctional protein, which plays a central role in phenylalanine biosynthesis, contains two catalytic domains (chorismate mutase and prephenate dehydratase) and a regulatory domain (ACT). It is part of the shikimate pathway. 2 vladimir 0.213958 0.3177 0.28742 0.1809 0.605142 0.394858 0.22865 0.239669 0.38292 0.14876 0.62259 0.37741 0.283747 0.269972 0.176309 0.269972 0.446281 0.553719 0.129477 0.443526 0.30303 0.123967 0.746556 0.253444 0.679414 39390.145 -0.142265 0.334254 0.524862 0.226519 0.085635 0.538674 0.461326 0.256906 0.132597 0.124309 5.737434 9.732044 NMV_0491 2191453 CDS +1 473524 474270 747 validated/Curated no recO DNA repair protein RecO (recombination protein O) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic RXN0-2606 2018-01-17 18:07:46 no Involved in DNA repair and RecF pathway recombination. Involved in pilin antigenic variation. 1 vladimir 0.202957 0.2688 0.329301 0.198925 0.598118 0.401882 0.185484 0.254032 0.370968 0.189516 0.625 0.375 0.274194 0.209677 0.225806 0.290323 0.435484 0.564516 0.149194 0.342742 0.391129 0.116935 0.733871 0.266129 0.591513 27751.74 -0.234008 0.275304 0.45749 0.242915 0.093117 0.554656 0.445344 0.283401 0.145749 0.137652 5.935997 9.708502 NMV_0492 2191454 CDS +2 474323 475051 729 validated/Curated no pdxJ pyridoxine 5'-phosphate synthase (pyridoxal phosphate biosynthetic protein PdxJ; PNP synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.6 : Pyridoxine (vitamin B6) ; 2.6.99.2 PDXJ-RXN PYRIDOXSYN-PWY 2020-02-21 11:05:23 no Is required in the biosynthesis of pyridoxine (vitamin B6), a precursor to the enzyme cofactor pyridoxal phosphate. Catalyses the following reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> pyridoxine 5'-phosphate + phosphate + 2 H2O. 1 vladimir 0.240055 0.3073 0.274348 0.178326 0.581619 0.418381 0.251029 0.255144 0.399177 0.09465 0.654321 0.345679 0.308642 0.230453 0.139918 0.320988 0.37037 0.62963 0.160494 0.436214 0.283951 0.119342 0.720165 0.279835 0.659759 26631.575 -0.012397 0.272727 0.475207 0.264463 0.082645 0.561983 0.438017 0.27686 0.140496 0.136364 5.564827 9.760331 NMV_0493 2191455 CDS +3 475203 475982 780 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:23:30 no 3 vladimir 0.375641 0.1282 0.179487 0.316667 0.307692 0.692308 0.380769 0.123077 0.280769 0.215385 0.403846 0.596154 0.403846 0.15 0.15 0.296154 0.3 0.7 0.342308 0.111538 0.107692 0.438462 0.219231 0.780769 0.488588 29503.99 -0.479923 0.235521 0.498069 0.235521 0.11583 0.459459 0.540541 0.277992 0.146718 0.131274 6.18412 8.988417 NMV_0494 2191456 CDS +3 475992 476759 768 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-13 17:23:43 no 3 vladimir 0.283854 0.1484 0.204427 0.363281 0.352865 0.647135 0.347656 0.132812 0.246094 0.273438 0.378906 0.621094 0.222656 0.15625 0.144531 0.476562 0.300781 0.699219 0.28125 0.15625 0.222656 0.339844 0.378906 0.621094 0.500499 28101.17 1.010196 0.25098 0.427451 0.392157 0.101961 0.698039 0.301961 0.113725 0.090196 0.023529 9.859825 7.862745 NMV_0495 2191457 CDS +1 476959 477336 378 validated/Curated no acpS holo-[acyl-carrier protein] synthase (holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; 2.7.8.7 HOLO-ACP-SYNTH-RXN PWY-6012 2020-04-22 12:25:39 no Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein. 2 vladimir 0.240741 0.2884 0.261905 0.208995 0.550265 0.449735 0.238095 0.190476 0.404762 0.166667 0.595238 0.404762 0.285714 0.230159 0.174603 0.309524 0.404762 0.595238 0.198413 0.444444 0.206349 0.150794 0.650794 0.349206 0.680559 13652.27 0.0424 0.304 0.464 0.224 0.12 0.624 0.376 0.256 0.144 0.112 8.971901 9.12 NMV_0496 2191458 CDS +2 477410 478219 810 validated/Curated no putative NUDIX hydrolase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-27 18:19:24 no Shows some similarity to MutT 1 vladimir 0.220988 0.2827 0.319753 0.176543 0.602469 0.397531 0.17037 0.262963 0.411111 0.155556 0.674074 0.325926 0.292593 0.225926 0.237037 0.244444 0.462963 0.537037 0.2 0.359259 0.311111 0.12963 0.67037 0.32963 0.590867 29902.62 -0.37658 0.304833 0.505576 0.208178 0.107807 0.568773 0.431227 0.256506 0.133829 0.122677 6.12719 9.977695 NMV_0497 2191459 CDS +3 478212 478634 423 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:24:29 no 1 vladimir 0.229314 0.2719 0.283688 0.21513 0.555556 0.444444 0.269504 0.241135 0.326241 0.163121 0.567376 0.432624 0.255319 0.255319 0.198582 0.29078 0.453901 0.546099 0.163121 0.319149 0.326241 0.191489 0.64539 0.35461 0.634853 15655.495 -0.039286 0.321429 0.492857 0.2 0.1 0.571429 0.428571 0.207143 0.114286 0.092857 8.594963 9.721429 NMV_0498 2191460 CDS +3 478683 479825 1143 validated/Curated no rimK/L ribosomal RNA large subunit methyltransferase K/L 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2018-01-17 18:19:28 no 22210896 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. 2 vladimir 0.218723 0.2975 0.271216 0.212598 0.568679 0.431321 0.228346 0.24147 0.354331 0.175853 0.595801 0.404199 0.275591 0.223097 0.223097 0.278215 0.446194 0.553806 0.152231 0.427822 0.23622 0.183727 0.664042 0.335958 0.692547 42614.145 -0.27 0.294737 0.510526 0.207895 0.102632 0.560526 0.439474 0.255263 0.142105 0.113158 9.227821 9.886842 NMV_0499 2191461 CDS -3 480126 480947 822 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-17 18:20:12 no Belongs to the Fic (filamentation induced by cAMP) family of proteins; Fic being involved in the synthesis of PAB or folate. 1 vladimir 0.277167 0.2369 0.211233 0.274725 0.448107 0.551893 0.263736 0.18315 0.289377 0.263736 0.472527 0.527473 0.351648 0.208791 0.157509 0.282051 0.3663 0.6337 0.216117 0.318681 0.186813 0.278388 0.505495 0.494506 0.603889 30979.875 -0.348529 0.264706 0.488971 0.213235 0.139706 0.536765 0.463235 0.235294 0.110294 0.125 5.085884 9.279412 NMV_0500 2191462 CDS -2 481024 482274 1251 validated/Curated no amiC N-acetylmuramoyl-L-alanine amidase AmiC 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 9 : Periplasmic 1.6.7 : Peptidoglycan (murein) ; 3.5.1.28 3.5.1.28-RXN 2020-02-22 16:46:30 no Hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. 2 vladimir 0.239009 0.3493 0.244604 0.167066 0.593925 0.406075 0.278177 0.263789 0.335731 0.122302 0.59952 0.40048 0.268585 0.270983 0.18705 0.273381 0.458034 0.541966 0.170264 0.513189 0.211031 0.105516 0.724221 0.275779 0.656522 45306.965 -0.29351 0.317308 0.550481 0.216346 0.074519 0.526442 0.473558 0.235577 0.146635 0.088942 9.985435 9.442308 NMV_0501 2191463 CDS -3 482271 482732 462 validated/Curated no tsaE tRNA threonylcarbamoyladenosine biosynthesis protein TsaE 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-17 18:21:29 no Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. 2 vladimir 0.218615 0.3139 0.261905 0.205628 0.575758 0.424242 0.188312 0.25974 0.357143 0.194805 0.616883 0.383117 0.246753 0.285714 0.207792 0.25974 0.493507 0.506494 0.220779 0.396104 0.220779 0.162338 0.616883 0.383117 0.639972 16772.3 -0.175817 0.346405 0.522876 0.20915 0.124183 0.568627 0.431373 0.254902 0.111111 0.143791 4.795464 9.313725 NMV_0503 2191465 CDS +3 482919 483731 813 validated/Curated no murI glr glutamate racemase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 5.1.1.3 GLUTRACE-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2018-02-12 18:32:58 no Converts L-glutamate into D-glutamate and is required for the biosynthesis of peptidoglycan. 1 vladimir 0.247232 0.2583 0.273063 0.221402 0.531365 0.468635 0.321033 0.191882 0.350554 0.136531 0.542435 0.457565 0.280443 0.247232 0.154982 0.317343 0.402214 0.597786 0.140221 0.335793 0.313653 0.210332 0.649446 0.350554 0.611788 29614.005 0.009259 0.292593 0.525926 0.259259 0.074074 0.566667 0.433333 0.225926 0.118519 0.107407 6.257927 9.877778 NMV_0504 2191466 CDS -3 485082 486191 1110 validated/Curated no putative protein adenylyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-21 14:40:34 no 23738009 1 vladimir 0.295496 0.2694 0.235135 0.2 0.504505 0.495496 0.302703 0.256757 0.294595 0.145946 0.551351 0.448649 0.313514 0.227027 0.172973 0.286486 0.4 0.6 0.27027 0.324324 0.237838 0.167568 0.562162 0.437838 0.533178 41783.5 -0.249322 0.271003 0.439024 0.238482 0.100271 0.539295 0.460705 0.257453 0.135501 0.121951 6.29937 9.460705 NMV_0506 2191468 CDS +3 490077 492239 2163 validated/Curated no tbp2 tbpB transferrin-binding protein 2 (TbpB) 1b : Function from experimental evidences in the studied species rc : receptor 8 : Outer membrane-associated 2008-06-17 15:10:18 no 10085238, 7928990 1 vladimir 0.329172 0.2210 0.247804 0.202034 0.468793 0.531207 0.330097 0.145631 0.363384 0.160888 0.509015 0.490985 0.393897 0.241331 0.188627 0.176144 0.429958 0.570042 0.263523 0.276006 0.191401 0.269071 0.467406 0.532594 0.62768 77953.515 -0.892222 0.352778 0.572222 0.122222 0.097222 0.461111 0.538889 0.2625 0.138889 0.123611 8.412529 9.181944 NMV_0507 2191469 CDS +1 492325 495069 2745 validated/Curated no tbp1 tbpA transferrin-binding protein 1 (TbpA) 1b : Function from experimental evidences in the studied species rc : receptor 8 : Outer membrane-associated 2008-06-17 15:10:37 no 8349090 1 vladimir 0.268852 0.2696 0.264845 0.196721 0.534426 0.465574 0.281967 0.191257 0.344262 0.182514 0.535519 0.464481 0.35082 0.209836 0.22623 0.213115 0.436066 0.563934 0.17377 0.40765 0.224044 0.194536 0.631694 0.368306 0.654782 102281.025 -0.662363 0.319475 0.527352 0.171772 0.129103 0.502188 0.497812 0.258206 0.155361 0.102845 9.42617 9.857768 NMV_0508 2191470 CDS -1 498803 499945 1143 validated/Curated no putative spermidine/putrescine-binding lipoprotein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 1.7.14 : Polyamine biosynthesis ; 2018-01-17 18:23:20 no This usually periplasmic spermidine/putrescine-binding protein is involved in the polyamine transport system. It is required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. 2 vladimir 0.278215 0.2800 0.253718 0.188101 0.533683 0.466317 0.309711 0.170604 0.362205 0.15748 0.532808 0.467192 0.354331 0.257218 0.128609 0.259843 0.385827 0.614173 0.170604 0.412073 0.270341 0.146982 0.682415 0.317585 0.770393 41355.515 -0.286053 0.289474 0.539474 0.210526 0.081579 0.563158 0.436842 0.242105 0.118421 0.123684 5.545067 9.031579 NMV_0509 2191471 CDS +1 500248 500511 264 validated/Curated no rpsT 30S ribosomal protein S20 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-17 18:23:48 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.32197 0.2992 0.238636 0.140152 0.537879 0.462121 0.272727 0.215909 0.409091 0.102273 0.625 0.375 0.340909 0.284091 0.170455 0.204545 0.454545 0.545455 0.352273 0.397727 0.136364 0.113636 0.534091 0.465909 0.823394 9507.64 -0.564368 0.344828 0.517241 0.172414 0.068966 0.471264 0.528736 0.344828 0.287356 0.057471 11.555565 9.022989 NMV_0510 2191472 CDS +2 500681 501820 1140 validated/Curated no putative phospholipase A1 (detergent-resistant phospholipase A; DR-phospholipase A; phosphatidylcholine 1-acylhydrolase; outer-membrane phospholipase A; OM PLA) 3 : Putative function from multiple computational evidences e : enzyme 7 : Outer membrane protein 3.1.1.32 PHOSPHOLIPASE-A1-RXN$RXN-12430$RXN0-6952 LIPASYN-PWY 2020-04-20 19:28:32 no Catalyses the following reaction: phosphatidylcholine + H(2)O <=> 2-acylglycerophosphocholine + a carboxylate. 1 vladimir 0.244681 0.2527 0.29078 0.211879 0.54344 0.45656 0.273936 0.207447 0.329787 0.18883 0.537234 0.462766 0.329787 0.212766 0.204787 0.25266 0.417553 0.582447 0.130319 0.337766 0.337766 0.194149 0.675532 0.324468 0.637177 41992.86 -0.4872 0.288 0.509333 0.189333 0.117333 0.546667 0.453333 0.237333 0.130667 0.106667 8.915718 9.704 NMV_0511 2191473 CDS +3 501963 502664 702 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-13 17:28:41 no 1 vladimir 0.220798 0.2365 0.283476 0.259259 0.519943 0.480057 0.24359 0.192308 0.358974 0.205128 0.551282 0.448718 0.24359 0.269231 0.136752 0.350427 0.405983 0.594017 0.175214 0.247863 0.354701 0.222222 0.602564 0.397436 0.631203 25088.39 0.369099 0.287554 0.562232 0.304721 0.085837 0.643777 0.356223 0.167382 0.090129 0.077253 8.94648 8.266094 NMV_0512 2191474 CDS +3 502722 504530 1809 validated/Curated no aspS non-discriminating aspartate-tRNA(Asp/Asn) ligase (non-discriminating aspartyl-tRNA synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.23 ASPARTATE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-30 13:02:11 no 16352843 Catalyses the attachment of aspartate to both Asp tRNA and Asn tRNA. 1 vladimir 0.254284 0.2836 0.259812 0.202322 0.543394 0.456606 0.245439 0.220564 0.379768 0.154229 0.600332 0.399668 0.331675 0.192371 0.179104 0.296849 0.371476 0.628524 0.185738 0.437811 0.220564 0.155887 0.658375 0.341625 0.817894 67928.835 -0.360797 0.245847 0.478405 0.215947 0.104651 0.543189 0.456811 0.297342 0.144518 0.152824 5.38517 9.825581 NMV_0513 2191475 CDS +3 504681 504965 285 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-02-13 17:29:10 no 3 vladimir 0.273684 0.2491 0.245614 0.231579 0.494737 0.505263 0.189474 0.210526 0.421053 0.178947 0.631579 0.368421 0.421053 0.189474 0.126316 0.263158 0.315789 0.684211 0.210526 0.347368 0.189474 0.252632 0.536842 0.463158 0.774133 10763.725 -0.558511 0.212766 0.457447 0.223404 0.117021 0.510638 0.489362 0.361702 0.170213 0.191489 5.071892 9.425532 NMV_0514 2191476 CDS +1 505132 507024 1893 validated/Curated no speA biosynthetic arginine decarboxylase (ADC) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.18 : Arginine degradation III (agmatinase pathway) ; 1.7.14.1 : Putrescine biosynthesis I ; 4.1.1.19 ARGDECARBOX-RXN PWY-40$PWY-6834$PWY0-1299$PWY0-823 2018-01-30 10:26:24 no Catalyses the following reaction, which is the first step in putrescine synthesis from arginine: L-arginine <=> agmatine + CO(2). 1 vladimir 0.248283 0.2388 0.25832 0.254622 0.497095 0.502905 0.207607 0.244057 0.351822 0.196513 0.59588 0.40412 0.342314 0.18859 0.18225 0.286846 0.37084 0.62916 0.194929 0.283677 0.240887 0.280507 0.524564 0.475436 0.625538 70817.585 -0.274762 0.263492 0.466667 0.236508 0.122222 0.549206 0.450794 0.265079 0.131746 0.133333 5.410378 9.757143 NMV_0515 2191477 CDS +3 507123 508046 924 validated/Curated no speB agmatinase (agmatine ureohydrolase; AUH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.18 : Arginine degradation III (agmatinase pathway) ; 1.7.14.1 : Putrescine biosynthesis I ; 3.5.3.11 AGMATIN-RXN PWY-40$PWY0-823 2018-01-30 10:25:59 no Catalyses the following reaction: agmatine + H(2)O <=> putrescine + urea. 2 vladimir 0.225108 0.2868 0.246753 0.241342 0.53355 0.46645 0.246753 0.204545 0.353896 0.194805 0.558442 0.441558 0.279221 0.230519 0.198052 0.292208 0.428571 0.571429 0.149351 0.425325 0.188312 0.237013 0.613636 0.386364 0.660545 33918.18 -0.163192 0.309446 0.534202 0.214984 0.123779 0.557003 0.442997 0.257329 0.127036 0.130293 5.368294 9.315961 NMV_0516 2191478 CDS +2 508244 509710 1467 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-17 18:30:33 no Belongs to the family of sodium symporters that mediate the intake of a molecule with the concomitant uptake of sodium ion. 1 vladimir 0.198364 0.2372 0.269939 0.294479 0.507157 0.492843 0.302658 0.145194 0.349693 0.202454 0.494888 0.505112 0.155419 0.284254 0.171779 0.388548 0.456033 0.543967 0.137014 0.282209 0.288344 0.292434 0.570552 0.429448 0.659103 51656.555 0.890984 0.362705 0.530738 0.282787 0.120902 0.739754 0.260246 0.104508 0.065574 0.038934 9.301414 8.514344 NMV_0517 2191479 CDS -2 509917 510951 1035 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-17 18:31:17 no Belongs to the ErfK/YbiS/YcfS/Ynh family of proteins that present a conserved region containing a histidine and cysteine suggesting that they have an enzymatic activity. 1 vladimir 0.267409 0.2971 0.234912 0.200557 0.532033 0.467967 0.275766 0.228412 0.342618 0.153203 0.571031 0.428969 0.300836 0.29805 0.16156 0.239554 0.45961 0.54039 0.225627 0.364902 0.200557 0.208914 0.56546 0.43454 0.598415 38548.245 -0.326257 0.329609 0.575419 0.198324 0.081006 0.547486 0.452514 0.22067 0.122905 0.097765 8.203819 9.243017 NMV_0519 2191481 CDS +1 511216 512358 1143 validated/Curated no bioF 8-amino-7-oxonoanoate synthase (AONS; 8-amino-7-ketopelargonate synthase; 7-keto-8-amino-pelargonic acid synthetase; 7-KAP synthetase; L-alanine--pimelyl CoA ligase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 2.3.1.47 7KAPSYN-RXN$RXN-11484 PWY-6519$PWY-6578 2018-01-17 18:31:56 no Is involved in biotin biosynthesis by catalysing the following reaction: 6-carboxyhexanoyl-CoA + L-alanine <=> 8-amino-7-oxononanoate + CoA + CO(2). 1 vladimir 0.265967 0.2108 0.232721 0.290464 0.44357 0.55643 0.262467 0.215223 0.272966 0.249344 0.488189 0.511811 0.317585 0.207349 0.167979 0.307087 0.375328 0.624672 0.217848 0.209974 0.257218 0.314961 0.467192 0.532808 0.579421 43204.975 -0.180789 0.271053 0.452632 0.228947 0.126316 0.539474 0.460526 0.223684 0.128947 0.094737 8.72068 9.397368 NMV_0520 2191482 CDS +1 512368 513015 648 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2008-02-13 17:30:34 no 3 vladimir 0.277778 0.2037 0.229938 0.28858 0.433642 0.566358 0.236111 0.194444 0.305556 0.263889 0.5 0.5 0.319444 0.208333 0.199074 0.273148 0.407407 0.592593 0.277778 0.208333 0.185185 0.328704 0.393519 0.606481 0.589262 24809.16 -0.315349 0.269767 0.465116 0.186047 0.181395 0.562791 0.437209 0.251163 0.139535 0.111628 6.310051 9.809302 NMV_0521 2191483 CDS +3 513003 513785 783 validated/Curated no bioC malonyl-[acyl-carrier protein] O-methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 2.1.1.197 RXN-11475 PWY-6519 2018-01-17 18:33:46 no Catalyses the following reaction: S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] <=> S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester. 1 vladimir 0.298851 0.2095 0.214559 0.277139 0.42401 0.57599 0.252874 0.203065 0.272031 0.272031 0.475096 0.524904 0.35249 0.214559 0.1341 0.298851 0.348659 0.651341 0.291188 0.210728 0.237548 0.260536 0.448276 0.551724 0.576694 29664.835 -0.195385 0.257692 0.453846 0.211538 0.15 0.557692 0.442308 0.215385 0.119231 0.096154 6.710915 8.942308 NMV_0522 2191484 CDS +3 514005 515441 1437 validated/Curated no conserved hypothetical TPR-containing protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-17 18:34:15 no Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.280891 0.2119 0.284483 0.222701 0.496408 0.503592 0.241379 0.211207 0.377155 0.170259 0.588362 0.411638 0.387931 0.198276 0.165948 0.247845 0.364224 0.635776 0.213362 0.226293 0.310345 0.25 0.536638 0.463362 0.605827 51808.38 -0.585745 0.259179 0.457883 0.218143 0.082073 0.514039 0.485961 0.295896 0.140389 0.155508 5.207008 9.287257 NMV_0523 2191485 CDS +2 515444 516541 1098 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:31:13 no 1 vladimir 0.276867 0.2213 0.248634 0.253188 0.469945 0.530055 0.297814 0.202186 0.289617 0.210383 0.491803 0.508197 0.311475 0.254098 0.131148 0.303279 0.385246 0.614754 0.221311 0.20765 0.325137 0.245902 0.532787 0.467213 0.570513 40834.74 -0.227945 0.265753 0.49863 0.232877 0.079452 0.531507 0.468493 0.230137 0.131507 0.09863 9.299065 8.991781 NMV_0524 2191486 CDS +1 516553 517089 537 validated/Curated no putative ATP/GTP-binding protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-02-13 17:31:25 no 1 vladimir 0.277467 0.1937 0.249534 0.27933 0.443203 0.556797 0.301676 0.156425 0.363128 0.178771 0.519553 0.480447 0.318436 0.206704 0.139665 0.335196 0.346369 0.653631 0.21229 0.217877 0.24581 0.324022 0.463687 0.536313 0.565508 19769.915 -0.085393 0.258427 0.505618 0.252809 0.095506 0.544944 0.455056 0.269663 0.129213 0.140449 5.191734 9.067416 NMV_0525 2191487 CDS +2 517091 517735 645 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:31:35 no 1 vladimir 0.251163 0.2326 0.254264 0.262015 0.486822 0.513178 0.251163 0.181395 0.330233 0.237209 0.511628 0.488372 0.325581 0.209302 0.15814 0.306977 0.367442 0.632558 0.176744 0.306977 0.274419 0.24186 0.581395 0.418605 0.653615 23629.015 -0.046729 0.28972 0.481308 0.257009 0.107477 0.570093 0.429907 0.224299 0.102804 0.121495 4.993279 8.883178 NMV_0526 2191488 CDS +3 517758 518117 360 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-17 18:35:17 no Belongs to the Roadblock/LC7 family of proteins that may modulate specific dynein functions. 2 vladimir 0.263889 0.2000 0.266667 0.269444 0.466667 0.533333 0.283333 0.158333 0.358333 0.2 0.516667 0.483333 0.241667 0.266667 0.141667 0.35 0.408333 0.591667 0.266667 0.175 0.3 0.258333 0.475 0.525 0.497196 12493.09 0.441176 0.352941 0.504202 0.319328 0.02521 0.588235 0.411765 0.201681 0.10084 0.10084 5.585869 8.319328 NMV_tRNA_15 2194830 tRNA +1 518210 518285 76 validated/Curated no Asn tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:50:20 no tRNA Asn anticodon GTT. vladimir NMV_0527 2191489 CDS -2 518797 519294 498 validated/Curated partial truncated TspB protein (N-terminal third of the protein) 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-17 18:36:12 no 16769696 Is part of a truncated filamentous bacteriophage, together with the upstream 5 genes. 2 vladimir 0.303922 0.1706 0.239216 0.286275 0.409804 0.590196 0.264706 0.111765 0.382353 0.241176 0.494118 0.505882 0.276471 0.211765 0.211765 0.3 0.423529 0.576471 0.370588 0.188235 0.123529 0.317647 0.311765 0.688235 0.463434 18682.67 -0.153846 0.319527 0.532544 0.230769 0.118343 0.544379 0.455621 0.272189 0.171598 0.100592 9.827568 8.934911 NMV_0529 2191491 CDS -3 519627 519905 279 validated/Curated no hypothetical protein 3 : Putative function from multiple computational evidences u : unknown 1 : Unknown 2018-01-17 18:36:36 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 1 vladimir 0.301075 0.2043 0.250896 0.243728 0.455197 0.544803 0.290323 0.215054 0.27957 0.215054 0.494624 0.505376 0.344086 0.11828 0.204301 0.333333 0.322581 0.677419 0.268817 0.27957 0.268817 0.182796 0.548387 0.451613 0.522401 10504.855 -0.079348 0.217391 0.423913 0.282609 0.119565 0.586957 0.413043 0.217391 0.130435 0.086957 8.957588 8.858696 NMV_0530 2191492 CDS -3 519912 520196 285 validated/Curated no hypothetical integral membrane protein 3 : Putative function from multiple computational evidences u : unknown 1 : Unknown 2018-01-17 18:36:55 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 1 vladimir 0.273684 0.2281 0.242105 0.25614 0.470175 0.529825 0.315789 0.115789 0.4 0.168421 0.515789 0.484211 0.252632 0.305263 0.115789 0.326316 0.421053 0.578947 0.252632 0.263158 0.210526 0.273684 0.473684 0.526316 0.733066 10002.515 0.446809 0.351064 0.531915 0.223404 0.106383 0.670213 0.329787 0.212766 0.159574 0.053191 10.085945 8.925532 NMV_0531 2191493 CDS -2 520204 520401 198 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2018-01-18 15:52:23 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 3 vladimir 0.30303 0.2121 0.212121 0.272727 0.424242 0.575758 0.227273 0.106061 0.393939 0.272727 0.5 0.5 0.393939 0.166667 0.106061 0.333333 0.272727 0.727273 0.287879 0.363636 0.136364 0.212121 0.5 0.5 0.665281 7377.93 -0.058462 0.246154 0.476923 0.230769 0.184615 0.569231 0.430769 0.230769 0.061538 0.169231 4.05323 9.292308 NMV_0532 2191494 CDS -1 520406 520750 345 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-18 15:52:51 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 2 vladimir 0.324638 0.2667 0.208696 0.2 0.475362 0.524638 0.33913 0.191304 0.295652 0.173913 0.486957 0.513043 0.33913 0.165217 0.208696 0.286957 0.373913 0.626087 0.295652 0.443478 0.121739 0.13913 0.565217 0.434783 0.660135 12551.805 -0.363158 0.298246 0.482456 0.210526 0.087719 0.508772 0.491228 0.210526 0.131579 0.078947 9.469215 9.035088 NMV_0533 2191495 fCDS -2 520741 521064 324 validated/Curated pseudo putative phage replication initiation factor (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 14:59:52 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. Homologous to the replication initiation factor (REP) initiating phage replication. This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the phage DNA at the origin of replication. 2 vladimir 0.342424 0.2394 0.184848 0.233333 0.424242 0.575758 0.263636 0.236364 0.272727 0.227273 0.509091 0.490909 0.490909 0.190909 0.081818 0.236364 0.272727 0.727273 0.272727 0.290909 0.2 0.236364 0.490909 0.509091 0.696457 12951.31 -0.766972 0.174312 0.348624 0.146789 0.201835 0.541284 0.458716 0.311927 0.174312 0.137615 7.121925 9.293578 NMV_0534 2191496 fCDS -3 521067 521774 708 validated/Curated pseudo putative phage replication initiation factor (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 14:59:40 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. Homologous to the replication initiation factor (REP) initiating phage replication. This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the phage DNA at the origin of replication. 2 vladimir 0.291667 0.2325 0.252688 0.223118 0.485215 0.514785 0.25 0.157258 0.379032 0.21371 0.53629 0.46371 0.354839 0.177419 0.221774 0.245968 0.399194 0.600806 0.270161 0.362903 0.157258 0.209677 0.520161 0.479839 0.690288 28187.7 -0.6 0.287449 0.465587 0.165992 0.1417 0.510121 0.489879 0.323887 0.165992 0.157895 6.192665 9.797571 NMV_0536 2191498 CDS +2 522278 523243 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 15:53:39 no Belongs to the IS30 family. 2 vladimir 0.322981 0.3075 0.206004 0.163561 0.513458 0.486542 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.381988 0.173913 0.226708 0.217391 0.400621 0.599379 0.242236 0.453416 0.177019 0.127329 0.630435 0.369565 0.567349 38033.11 -0.916822 0.249221 0.392523 0.193146 0.130841 0.417445 0.582555 0.327103 0.23676 0.090343 10.146294 9.76947 NMV_0537 2191499 CDS -1 523232 524281 1050 validated/Curated partial tpsS1 putative TpsS1 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 15:53:58 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.305949 0.2285 0.259679 0.205855 0.488196 0.511804 0.291785 0.175637 0.396601 0.135977 0.572238 0.427762 0.348442 0.246459 0.1983 0.206799 0.444759 0.555241 0.27762 0.263456 0.184136 0.274788 0.447592 0.552408 0.54171 37860.465 -0.430398 0.360795 0.553977 0.184659 0.102273 0.545455 0.454545 0.221591 0.119318 0.102273 7.195091 9.696023 NMV_0538 2191500 fCDS -1 524294 524671 378 validated/Curated pseudo conserved hypothetical protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:08:19 no 1 vladimir 0.293144 0.2246 0.245863 0.236407 0.470449 0.529551 0.319149 0.177305 0.304965 0.198582 0.48227 0.51773 0.326241 0.184397 0.212766 0.276596 0.397163 0.602837 0.234043 0.312057 0.219858 0.234043 0.531915 0.468085 0.564523 15848.375 -0.372857 0.264286 0.507143 0.214286 0.114286 0.521429 0.478571 0.278571 0.142857 0.135714 5.77108 9.4 NMV_0539 2191501 fCDS -2 524635 524787 153 validated/Curated pseudo conserved hypothetical protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:08:33 no 3 vladimir 0.348718 0.1846 0.164103 0.302564 0.348718 0.651282 0.323077 0.230769 0.184615 0.261538 0.415385 0.584615 0.369231 0.2 0.123077 0.307692 0.323077 0.676923 0.353846 0.123077 0.184615 0.338462 0.307692 0.692308 0.413253 7371.235 -0.020313 0.234375 0.453125 0.25 0.15625 0.59375 0.40625 0.140625 0.078125 0.0625 6.005745 9.09375 NMV_0540 2191502 CDS -1 524906 527215 2310 validated/Curated partial tpsS2 putative TpsS2 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 15:54:28 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.301646 0.2560 0.268313 0.174074 0.52428 0.47572 0.323457 0.191358 0.366667 0.118519 0.558025 0.441975 0.324691 0.233333 0.234568 0.207407 0.467901 0.532099 0.25679 0.34321 0.203704 0.196296 0.546914 0.453086 0.560001 86609.9 -0.531891 0.388133 0.548826 0.174289 0.08529 0.493201 0.506799 0.239802 0.139679 0.100124 9.267769 9.196539 NMV_0541 2191503 CDS -2 527434 527910 477 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:04:40 no 3 vladimir 0.339623 0.1237 0.197065 0.339623 0.320755 0.679245 0.27673 0.113208 0.339623 0.27044 0.45283 0.54717 0.433962 0.144654 0.132075 0.289308 0.27673 0.72327 0.308176 0.113208 0.119497 0.459119 0.232704 0.767296 0.512527 18285.635 -0.364557 0.227848 0.474684 0.202532 0.177215 0.531646 0.468354 0.291139 0.101266 0.189873 4.261086 9.531646 NMV_0542 2191504 CDS -3 527913 530048 2136 validated/Curated partial tpsS3 putative TpsS3 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 15:54:51 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.333333 0.2346 0.254213 0.177903 0.488764 0.511236 0.349719 0.176966 0.366573 0.106742 0.543539 0.456461 0.365169 0.254213 0.191011 0.189607 0.445225 0.554775 0.285112 0.272472 0.205056 0.23736 0.477528 0.522472 0.546393 76455.94 -0.671027 0.35865 0.552743 0.164557 0.082982 0.483826 0.516174 0.253165 0.153305 0.099859 9.513435 9.302391 NMV_0545 2191507 CDS -1 530354 530704 351 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 17:42:13 no 3 vladimir 0.364672 0.1766 0.179487 0.279202 0.356125 0.643875 0.376068 0.162393 0.290598 0.17094 0.452991 0.547009 0.316239 0.25641 0.145299 0.282051 0.401709 0.598291 0.401709 0.111111 0.102564 0.384615 0.213675 0.786325 0.424503 12838.325 -0.306897 0.267241 0.525862 0.258621 0.077586 0.534483 0.465517 0.241379 0.155172 0.086207 9.790611 9.051724 NMV_0546 2191508 CDS -2 530860 531306 447 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 17:42:24 no 3 vladimir 0.357942 0.1208 0.17226 0.348993 0.293065 0.706935 0.275168 0.174497 0.315436 0.234899 0.489933 0.510067 0.42953 0.14094 0.09396 0.33557 0.234899 0.765101 0.369128 0.04698 0.107383 0.47651 0.154362 0.845638 0.581764 17107.925 -0.213514 0.182432 0.405405 0.25 0.114865 0.533784 0.466216 0.263514 0.101351 0.162162 4.519676 9.182432 NMV_0547 2191509 CDS -3 531321 538811 7491 validated/Curated partial tpsA truncated haemagglutinin/hemolysin-related protein TpsA (C-terminal 90% of the protein) 3 : Putative function from multiple computational evidences e : enzyme 7 : Outer membrane protein 2018-03-23 15:14:19 no 15546669, 16472308, 17873034 Is interrupted by a ISNmE1 transposase. 1 vladimir 0.322156 0.2426 0.234597 0.200665 0.477179 0.522821 0.340918 0.192814 0.355289 0.110978 0.548104 0.451896 0.348503 0.229541 0.209182 0.212774 0.438723 0.561277 0.277046 0.305389 0.139321 0.278244 0.444711 0.555289 0.581143 267328.515 -0.578075 0.367812 0.570687 0.186901 0.077875 0.467652 0.532348 0.225639 0.130192 0.095447 8.866051 9.224042 NMV_0548 2191510 CDS +1 538876 539883 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 15:56:22 no Belongs to the IS5 family. 2 vladimir 0.280754 0.2986 0.227183 0.193452 0.525794 0.474206 0.279762 0.291667 0.270833 0.157738 0.5625 0.4375 0.372024 0.199405 0.178571 0.25 0.377976 0.622024 0.190476 0.404762 0.232143 0.172619 0.636905 0.363095 0.656795 38416.52 -0.522985 0.268657 0.423881 0.20597 0.122388 0.492537 0.507463 0.286567 0.176119 0.110448 9.080742 9.244776 NMV_0549 2191511 CDS -3 540030 540944 915 validated/Curated partial tpsA truncated haemagglutinin/hemolysin-related protein TpsA (N-terminal 10% of the protein) 3 : Putative function from multiple computational evidences e : enzyme 7 : Outer membrane protein 2018-03-23 15:14:01 no 15546669, 16472308, 17873034 Is interrupted by a ISNme1 transposase. 1 vladimir 0.264706 0.2559 0.228431 0.25098 0.484314 0.515686 0.294118 0.211765 0.329412 0.164706 0.541176 0.458824 0.276471 0.288235 0.188235 0.247059 0.476471 0.523529 0.223529 0.267647 0.167647 0.341176 0.435294 0.564706 0.604337 35561.12 -0.238938 0.368732 0.622419 0.20649 0.070796 0.533923 0.466077 0.150442 0.091445 0.058997 9.485771 9.023599 NMV_0550 2191512 CDS -2 541054 541500 447 validated/Curated no IS605 family transposase protein A 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-02-13 17:43:08 no 3 vladimir 0.295302 0.1633 0.212528 0.328859 0.375839 0.624161 0.268456 0.194631 0.302013 0.234899 0.496644 0.503356 0.328859 0.14094 0.187919 0.342282 0.328859 0.671141 0.288591 0.154362 0.147651 0.409396 0.302013 0.697987 0.570933 17130.125 -0.155405 0.209459 0.432432 0.27027 0.141892 0.540541 0.459459 0.277027 0.162162 0.114865 8.574028 9.175676 NMV_0551 2191513 fCDS +2 541514 542185 672 validated/Curated pseudo IS605 family transposase protein B (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:09:11 no 1 vladimir 0.348214 0.2158 0.196429 0.239583 0.412202 0.587798 0.325893 0.21875 0.232143 0.223214 0.450893 0.549107 0.383929 0.138393 0.200893 0.276786 0.339286 0.660714 0.334821 0.290179 0.15625 0.21875 0.446429 0.553571 0.635098 26354.53 -0.674888 0.215247 0.372197 0.174888 0.143498 0.484305 0.515695 0.295964 0.201794 0.09417 10.03318 8.834081 NMV_0553 2191515 fCDS +2 542219 542653 435 validated/Curated pseudo IS605 family transposase protein B (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:09:26 no 1 vladimir 0.321839 0.2115 0.245977 0.22069 0.457471 0.542529 0.296552 0.213793 0.289655 0.2 0.503448 0.496552 0.406897 0.158621 0.2 0.234483 0.358621 0.641379 0.262069 0.262069 0.248276 0.227586 0.510345 0.489655 0.623878 16310.705 -0.5875 0.277778 0.472222 0.201389 0.118056 0.472222 0.527778 0.256944 0.159722 0.097222 8.324837 9.680556 NMNmiscRNA0165 54919398 misc_RNA -1 542865 543073 209 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:47:47 28334889 Function unknown. vladimir NMV_0554 2191516 CDS -2 543148 544050 903 validated/Curated no putative replication initiation protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-02-25 13:25:13 no Homologous to RepB, an initiator of plasmid replication that possesses nicking-closing (topoisomerase I-like) activity. 3 vladimir 0.332226 0.1750 0.24031 0.252492 0.415282 0.584718 0.342193 0.156146 0.332226 0.169435 0.488372 0.511628 0.355482 0.202658 0.146179 0.295681 0.348837 0.651163 0.299003 0.166113 0.242525 0.292359 0.408638 0.591362 0.519555 34387.225 -0.398 0.243333 0.44 0.223333 0.1 0.496667 0.503333 0.3 0.16 0.14 8.712349 9.27 NMV_0555 2191517 CDS +1 544078 545757 1680 validated/Curated no tpsB1 TpsA1 activation/secretion protein TpsB1 1b : Function from experimental evidences in the studied species t : transporter 7 : Outer membrane protein 2018-01-18 15:58:07 no 15546669, 16472308, 17873034 Belongs to a family of outer membrane proteins, encoded by genes generically designated tpsB, that transport the TpsA proteins across the outer membrane during a process known as two-partner secretion (TPS). 1 vladimir 0.286905 0.2274 0.244643 0.241071 0.472024 0.527976 0.282143 0.207143 0.305357 0.205357 0.5125 0.4875 0.348214 0.192857 0.216071 0.242857 0.408929 0.591071 0.230357 0.282143 0.2125 0.275 0.494643 0.505357 0.596599 63307.85 -0.610018 0.29517 0.466905 0.177102 0.134168 0.502683 0.497317 0.257603 0.153846 0.103757 9.393593 9.431127 NMV_0556 2191518 CDS +1 545866 551589 5724 validated/Curated no tpsA1 haemagglutinin/hemolysin-related protein TpsA1 1b : Function from experimental evidences in the studied species f : factor 10 : Secreted 2018-01-18 15:58:23 no 15546669, 16472308, 17873034 Belongs to a family of large secreted proteins that may have haemagglutinin or haemolysin activity. These proteins, encoded by genes generically designated tpsA, are secreted by the two-partner secretion system (TPS) in which the transport across the outer membrane requires a dedicated outer membrane protein, encoded by genes generically designated tpsB. 1 vladimir 0.302061 0.2416 0.249301 0.207023 0.490915 0.509085 0.345388 0.161426 0.381027 0.112159 0.542453 0.457547 0.303983 0.259434 0.196541 0.240042 0.455975 0.544025 0.256813 0.303983 0.170335 0.268868 0.474319 0.525681 0.611348 198091.56 -0.209544 0.39591 0.596749 0.216571 0.055585 0.520713 0.479287 0.198217 0.11484 0.083377 9.239571 8.8301 NMV_0557 2191519 CDS +3 551601 551996 396 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:44:39 no 3 vladimir 0.361111 0.1212 0.199495 0.318182 0.320707 0.679293 0.356061 0.083333 0.295455 0.265152 0.378788 0.621212 0.378788 0.166667 0.136364 0.318182 0.30303 0.69697 0.348485 0.113636 0.166667 0.371212 0.280303 0.719697 0.440314 15221.72 -0.141985 0.236641 0.435115 0.236641 0.129771 0.534351 0.465649 0.244275 0.083969 0.160305 4.373344 9.870229 NMV_0558 2191520 CDS +1 552367 553146 780 validated/Curated no putative haemagglutinin/hemolysin-related protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 15:58:45 no Unlike the TpsS minicassettes, this entry N-terminus shows no homology to TpsA. 3 vladimir 0.334615 0.1808 0.196154 0.288462 0.376923 0.623077 0.323077 0.176923 0.303846 0.196154 0.480769 0.519231 0.315385 0.257692 0.161538 0.265385 0.419231 0.580769 0.365385 0.107692 0.123077 0.403846 0.230769 0.769231 0.461212 28169.03 -0.232819 0.320463 0.521236 0.216216 0.088803 0.548263 0.451737 0.196911 0.123552 0.073359 9.575386 9.065637 NMV_0559 2191521 CDS +2 553151 553534 384 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:45:03 no 3 vladimir 0.424479 0.1120 0.143229 0.320312 0.255208 0.744792 0.414062 0.085938 0.234375 0.265625 0.320312 0.679688 0.460938 0.148438 0.070312 0.320312 0.21875 0.78125 0.398438 0.101562 0.125 0.375 0.226562 0.773438 0.49458 15254.94 -0.368504 0.181102 0.338583 0.220472 0.15748 0.480315 0.519685 0.291339 0.133858 0.15748 5.076805 8.992126 NMV_0560 2191522 CDS +2 553784 554191 408 validated/Curated partial tpsS4 putative TpsS4 cassette (N-terminal 15%) 5 : Unknown function f : factor 1 : Unknown 2018-01-27 18:22:02 no 16472308 Is interrupted by a ISNme1 transposase. 2 vladimir 0.313726 0.3039 0.220588 0.161765 0.52451 0.47549 0.345588 0.169118 0.345588 0.139706 0.514706 0.485294 0.345588 0.257353 0.198529 0.198529 0.455882 0.544118 0.25 0.485294 0.117647 0.147059 0.602941 0.397059 0.690272 14521.78 -0.474815 0.37037 0.525926 0.185185 0.088889 0.518519 0.481481 0.251852 0.148148 0.103704 9.223763 8.703704 NMV_0561 2191523 CDS -2 554338 555345 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 15:59:22 no Belongs to the IS5 family. 2 vladimir 0.287698 0.3006 0.223214 0.188492 0.52381 0.47619 0.285714 0.28869 0.267857 0.157738 0.556548 0.443452 0.372024 0.205357 0.178571 0.244048 0.383929 0.616071 0.205357 0.407738 0.223214 0.16369 0.630952 0.369048 0.675318 38481.62 -0.608955 0.268657 0.420896 0.2 0.119403 0.477612 0.522388 0.298507 0.191045 0.107463 9.514824 9.220896 NMV_0562 2191524 CDS +2 555386 557509 2124 validated/Curated partial tpsS4 putative TpsS4 cassette (C-terminal 85%) 5 : Unknown function f : factor 1 : Unknown 2018-01-27 18:22:14 no 16472308 Is interrupted by a ISNme1 transposase. 1 vladimir 0.310264 0.2538 0.25 0.18597 0.503766 0.496234 0.331921 0.169492 0.38983 0.108757 0.559322 0.440678 0.29096 0.286723 0.185028 0.237288 0.471751 0.528249 0.30791 0.305085 0.175141 0.211864 0.480226 0.519774 0.550166 74843.68 -0.164922 0.377652 0.572843 0.213579 0.074965 0.553041 0.446959 0.205092 0.12447 0.080622 9.55146 9.274399 NMV_0563 2191525 CDS +1 557506 557994 489 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:15:01 no 3 vladimir 0.345603 0.1166 0.188139 0.349693 0.304703 0.695296 0.263804 0.122699 0.288344 0.325153 0.411043 0.588957 0.466258 0.153374 0.104294 0.276074 0.257669 0.742331 0.306748 0.07362 0.171779 0.447853 0.245399 0.754601 0.529317 19581.305 -0.624074 0.191358 0.376543 0.179012 0.228395 0.5 0.5 0.314815 0.148148 0.166667 5.131386 9.469136 NMV_0564 2191526 CDS +1 558181 558453 273 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-13 17:45:56 no 3 vladimir 0.344322 0.1209 0.201465 0.333333 0.322344 0.677656 0.263736 0.153846 0.296703 0.285714 0.450549 0.549451 0.472527 0.120879 0.164835 0.241758 0.285714 0.714286 0.296703 0.087912 0.142857 0.472527 0.230769 0.769231 0.612665 10807.735 -0.7 0.2 0.411111 0.133333 0.2 0.544444 0.455556 0.311111 0.111111 0.2 4.358604 10.733333 NMV_0565 2191527 CDS +3 558633 559772 1140 validated/Curated partial tpsS5 putative TpsS5 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:00:01 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.366667 0.1772 0.203509 0.252632 0.380702 0.619298 0.376316 0.147368 0.313158 0.163158 0.460526 0.539474 0.365789 0.239474 0.171053 0.223684 0.410526 0.589474 0.357895 0.144737 0.126316 0.371053 0.271053 0.728947 0.513278 42106.76 -0.638786 0.316623 0.511873 0.17942 0.08971 0.459103 0.540897 0.274406 0.163588 0.110818 9.444756 9.094987 NMV_0566 2191528 CDS +3 559788 560219 432 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-13 17:46:25 no 3 vladimir 0.395833 0.1273 0.12963 0.347222 0.256944 0.743056 0.381944 0.118056 0.243056 0.256944 0.361111 0.638889 0.4375 0.180556 0.083333 0.298611 0.263889 0.736111 0.368056 0.083333 0.0625 0.486111 0.145833 0.854167 0.517859 16726.28 -0.313986 0.223776 0.41958 0.20979 0.188811 0.503497 0.496503 0.251748 0.118881 0.132867 5.12957 9.104895 NMV_0567 2191529 CDS +3 560364 562676 2313 validated/Curated partial tpsS6 putative TpsS6 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:00:31 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.319498 0.2404 0.244704 0.195417 0.485084 0.514916 0.342412 0.155642 0.383917 0.118029 0.539559 0.460441 0.351492 0.250324 0.158236 0.239948 0.40856 0.59144 0.264591 0.315175 0.191959 0.228275 0.507134 0.492866 0.610533 82112.375 -0.304675 0.349351 0.563636 0.212987 0.072727 0.522078 0.477922 0.228571 0.133766 0.094805 9.350868 8.898701 NMV_0568 2191530 CDS +2 562685 563062 378 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:12:21 no 3 vladimir 0.383598 0.1085 0.177249 0.330688 0.285714 0.714286 0.373016 0.079365 0.277778 0.269841 0.357143 0.642857 0.428571 0.174603 0.087302 0.309524 0.261905 0.738095 0.349206 0.071429 0.166667 0.412698 0.238095 0.761905 0.475969 14437.73 -0.3728 0.224 0.464 0.216 0.128 0.48 0.52 0.272 0.104 0.168 4.449928 8.536 NMV_0570 2191532 CDS +3 563340 563714 375 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:15:26 no 3 vladimir 0.370667 0.1120 0.189333 0.328 0.301333 0.698667 0.312 0.128 0.296 0.264 0.424 0.576 0.456 0.128 0.136 0.28 0.264 0.736 0.344 0.08 0.136 0.44 0.216 0.784 0.537655 14755.865 -0.717742 0.201613 0.403226 0.169355 0.153226 0.443548 0.556452 0.322581 0.112903 0.209677 4.344612 9.096774 NMV_0571 2191533 CDS +1 563842 565344 1503 validated/Curated partial tpsS7 putative TpsS7 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:00:52 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.283208 0.2155 0.27005 0.231203 0.485589 0.514411 0.31015 0.135338 0.424812 0.129699 0.56015 0.43985 0.304511 0.287594 0.152256 0.255639 0.43985 0.56015 0.234962 0.223684 0.233083 0.308271 0.456767 0.543233 0.594199 55576.18 0.016761 0.369115 0.600753 0.227872 0.071563 0.591337 0.408663 0.205273 0.124294 0.080979 9.338585 9.067797 NMV_0572 2191534 CDS +1 565363 565626 264 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:15:55 no 3 vladimir 0.367424 0.0985 0.219697 0.314394 0.318182 0.681818 0.261364 0.125 0.329545 0.284091 0.454545 0.545455 0.522727 0.068182 0.159091 0.25 0.227273 0.772727 0.318182 0.102273 0.170455 0.409091 0.272727 0.727273 0.545404 10684.78 -0.770115 0.16092 0.310345 0.126437 0.241379 0.574713 0.425287 0.37931 0.16092 0.218391 4.737785 10.54023 NMV_0573 2191535 CDS +2 565733 567835 2103 validated/Curated partial tpsS8 putative TpsS8 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:01:09 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.305754 0.2192 0.260105 0.214931 0.479315 0.520685 0.340942 0.146933 0.378031 0.134094 0.524964 0.475036 0.333809 0.252496 0.168331 0.245364 0.420827 0.579173 0.242511 0.258203 0.233951 0.265335 0.492154 0.507846 0.574997 74649.645 -0.212286 0.354286 0.552857 0.211429 0.075714 0.542857 0.457143 0.227143 0.131429 0.095714 9.223442 8.851429 NMV_0574 2191536 CDS +3 567894 568337 444 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-21 11:07:56 no 3 vladimir 0.273563 0.1080 0.177011 0.441379 0.285057 0.714943 0.289655 0.096552 0.227586 0.386207 0.324138 0.675862 0.193103 0.137931 0.17931 0.489655 0.317241 0.682759 0.337931 0.089655 0.124138 0.448276 0.213793 0.786207 0.430641 16614.025 0.926389 0.236111 0.416667 0.326389 0.229167 0.701389 0.298611 0.090278 0.055556 0.034722 9.01313 7.819444 NMV_0576 2191538 CDS +3 568848 569783 936 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:15:33 no 1 vladimir 0.287393 0.2286 0.225427 0.258547 0.45406 0.54594 0.278846 0.208333 0.304487 0.208333 0.51282 0.487179 0.403846 0.192308 0.105769 0.298077 0.298077 0.701923 0.179487 0.285256 0.266026 0.269231 0.551282 0.448718 0.647544 36514.37 -0.402251 0.202572 0.421222 0.186495 0.170418 0.549839 0.450161 0.282958 0.131833 0.151125 5.018593 9.649518 NMV_0578 2191540 CDS +1 570016 570951 936 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:19:08 no 1 vladimir 0.28312 0.2222 0.226496 0.268162 0.448718 0.551282 0.282051 0.211538 0.304487 0.201923 0.516026 0.483974 0.387821 0.185897 0.112179 0.314103 0.298077 0.701923 0.179487 0.269231 0.262821 0.288462 0.532051 0.467949 0.617123 36436.37 -0.303215 0.205788 0.421222 0.199357 0.167203 0.553055 0.446945 0.273312 0.131833 0.141479 5.228371 9.610932 NMV_0581 2191543 CDS +3 571527 572015 489 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 12:19:20 no 3 vladimir 0.341513 0.1227 0.188139 0.347648 0.310838 0.689162 0.263804 0.134969 0.282209 0.319018 0.417178 0.582822 0.460123 0.165644 0.104294 0.269939 0.269939 0.730061 0.300613 0.067485 0.177914 0.453988 0.245399 0.754601 0.504626 19579.325 -0.65679 0.191358 0.388889 0.179012 0.222222 0.5 0.5 0.308642 0.148148 0.160494 5.263405 9.574074 NMV_0582 2191544 CDS +1 572203 572475 273 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 12:19:31 no 3 vladimir 0.344322 0.1209 0.201465 0.333333 0.322344 0.677656 0.263736 0.153846 0.296703 0.285714 0.450549 0.549451 0.472527 0.120879 0.164835 0.241758 0.285714 0.714286 0.296703 0.087912 0.142857 0.472527 0.230769 0.769231 0.612665 10807.735 -0.7 0.2 0.411111 0.133333 0.2 0.544444 0.455556 0.311111 0.111111 0.2 4.358604 10.733333 NMV_0583 2191545 CDS +1 572788 573366 579 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:16:28 no 1 vladimir 0.302245 0.2003 0.231434 0.265976 0.431779 0.568221 0.284974 0.196891 0.295337 0.222798 0.492228 0.507772 0.404145 0.15544 0.145078 0.295337 0.300518 0.699482 0.217617 0.248705 0.253886 0.279793 0.502591 0.497409 0.518651 22640.735 -0.50625 0.1875 0.416667 0.244792 0.161458 0.494792 0.505208 0.3125 0.166667 0.145833 6.073677 9.369792 NMV_0584 2191546 CDS +3 573447 574169 723 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 12:19:55 no 1 vladimir 0.279391 0.2282 0.235131 0.257261 0.463347 0.536653 0.290456 0.178423 0.319502 0.211618 0.497925 0.502075 0.340249 0.207469 0.141079 0.311203 0.348548 0.651452 0.207469 0.298755 0.244813 0.248963 0.543568 0.456432 0.632577 26587.215 -0.137083 0.279167 0.504167 0.241667 0.095833 0.529167 0.470833 0.229167 0.1125 0.116667 5.41198 9.008333 NMV_0585 2191547 CDS +2 574604 575005 402 validated/Curated partial truncated putative replication initiation protein 5 : Unknown function f : factor 2 : Cytoplasmic 2008-06-12 12:54:16 no 3 vladimir 0.353583 0.1807 0.218069 0.247664 0.398754 0.601246 0.392523 0.126168 0.247664 0.233645 0.373832 0.626168 0.364486 0.17757 0.163551 0.294393 0.341121 0.658879 0.303738 0.238318 0.242991 0.214953 0.481308 0.518692 0.493867 24370.2 -0.318779 0.253521 0.431925 0.230047 0.117371 0.516432 0.483568 0.2723 0.150235 0.122066 8.266731 8.821596 NMV_0585.1 2662680 CDS -2 575113 575349 237 validated/Curated partial truncated ISNme1 transposase (N-terminal 25% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-18 16:02:14 Belongs to the IS5 family. vladimir NMV_0587 2191549 CDS +2 576107 583666 7560 validated/Curated no tpsA2 haemagglutinin/hemolysin-related protein TpsA2 1b : Function from experimental evidences in the studied species f : factor 10 : Secreted 2018-01-18 16:02:28 no 15546669, 16472308, 17873034 Belongs to a family of large secreted proteins that may have haemagglutinin or haemolysin activity. These proteins, encoded by genes generically designated tpsA, are secreted by the two-partner secretion system (TPS) in which the transport across the outer membrane requires a dedicated outer membrane protein, encoded by genes generically designated tpsB. 3 vladimir 0.339021 0.2269 0.223148 0.210979 0.45 0.55 0.358333 0.170635 0.342857 0.128175 0.513492 0.486508 0.361508 0.230556 0.200397 0.20754 0.430952 0.569048 0.297222 0.279365 0.12619 0.297222 0.405556 0.594444 0.615111 268492.05 -0.593132 0.370385 0.579992 0.181024 0.076221 0.456927 0.543073 0.209607 0.115125 0.094482 6.686455 9.079794 NMV_0588 2191550 CDS +3 583647 583955 309 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2018-01-30 19:03:33 no 3 vladimir 0.343042 0.1489 0.190939 0.317152 0.339806 0.660194 0.320388 0.174757 0.262136 0.242718 0.436893 0.563107 0.378641 0.145631 0.165049 0.31068 0.31068 0.68932 0.330097 0.126214 0.145631 0.398058 0.271845 0.728155 0.474472 11694.055 -0.135294 0.264706 0.441176 0.235294 0.156863 0.519608 0.480392 0.27451 0.166667 0.107843 7.147987 8.970588 NMV_0590 2191552 CDS +2 584303 586228 1926 validated/Curated partial tpsS9 putative TpsS9 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:02:56 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.359294 0.1791 0.216511 0.245067 0.395639 0.604361 0.350467 0.132399 0.344237 0.172897 0.476636 0.523364 0.419003 0.207165 0.174455 0.199377 0.38162 0.61838 0.308411 0.197819 0.130841 0.362928 0.32866 0.67134 0.581993 70958.03 -0.849766 0.304212 0.550702 0.165367 0.104524 0.450858 0.549142 0.277691 0.137285 0.140406 5.493904 9.418097 NMV_0591 2191553 CDS +1 586228 586659 432 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2018-01-30 19:05:35 no 3 vladimir 0.361111 0.1389 0.178241 0.321759 0.31713 0.68287 0.333333 0.125 0.243056 0.298611 0.368056 0.631944 0.402778 0.159722 0.173611 0.263889 0.333333 0.666667 0.347222 0.131944 0.118056 0.402778 0.25 0.75 0.509823 16817.62 -0.511888 0.258741 0.433566 0.174825 0.174825 0.503497 0.496503 0.286713 0.160839 0.125874 8.191109 9.34965 NMV_0592 2191554 CDS +3 586701 586952 252 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-02-14 12:22:45 no 3 vladimir 0.400794 0.1468 0.134921 0.31746 0.281746 0.718254 0.392857 0.130952 0.22619 0.25 0.357143 0.642857 0.464286 0.178571 0.095238 0.261905 0.27381 0.72619 0.345238 0.130952 0.083333 0.440476 0.214286 0.785714 0.644597 9889.97 -0.73253 0.168675 0.409639 0.156627 0.192771 0.518072 0.481928 0.301205 0.180723 0.120482 8.685646 9.554217 NMV_0594 2191556 CDS +3 587271 588236 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:03:15 no Belongs to the IS30 family. 2 vladimir 0.319876 0.3085 0.206004 0.165631 0.514493 0.485507 0.338509 0.298137 0.214286 0.149068 0.512422 0.487578 0.381988 0.177019 0.223602 0.217391 0.400621 0.599379 0.23913 0.450311 0.180124 0.130435 0.630435 0.369565 0.56321 38008.02 -0.911838 0.249221 0.395639 0.190031 0.133956 0.420561 0.579439 0.320872 0.23053 0.090343 10.089043 9.76947 NMV_0595 2191557 CDS +1 588334 591900 3567 validated/Curated partial tpsS10 putative TpsS10 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-18 16:03:29 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.35018 0.2439 0.229218 0.176747 0.473074 0.526926 0.37034 0.158244 0.371168 0.100249 0.529412 0.470588 0.344656 0.264292 0.207125 0.183927 0.471417 0.528583 0.335543 0.309031 0.109362 0.246065 0.418393 0.581607 0.605747 124643.115 -0.510365 0.430348 0.611111 0.167496 0.063018 0.466003 0.533997 0.192371 0.114428 0.077944 9.128807 8.718076 NMV_0596 2191558 CDS +1 591901 592338 438 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:25:07 no 3 vladimir 0.363014 0.1073 0.143836 0.385845 0.251142 0.748858 0.349315 0.09589 0.260274 0.294521 0.356164 0.643836 0.376712 0.136986 0.082192 0.40411 0.219178 0.780822 0.363014 0.089041 0.089041 0.458904 0.178082 0.821918 0.525043 17021.01 0.143448 0.151724 0.42069 0.310345 0.165517 0.565517 0.434483 0.227586 0.096552 0.131034 4.703926 8.406897 NMV_0597 2191559 CDS +3 592488 592946 459 validated/Curated no putative FrpA/C-activating lysine-acyltransferase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2.3.1.- 2018-01-18 16:03:54 no Belongs to the RTXC family of acyl-carrier-protein-dependent acyl-modification enzymes, required to convert the RTX proteins to their active form. 1 vladimir 0.263617 0.2309 0.224401 0.281046 0.455338 0.544662 0.281046 0.24183 0.222222 0.254902 0.464052 0.535948 0.300654 0.20915 0.202614 0.287582 0.411765 0.588235 0.20915 0.24183 0.248366 0.300654 0.490196 0.509804 0.519096 17733.715 -0.266447 0.25 0.440789 0.217105 0.177632 0.559211 0.440789 0.210526 0.131579 0.078947 8.563881 9.230263 NMV_0598 2191560 CDS +3 593001 594788 1788 validated/Curated no tpsB2 TpsA2 activation/secretion protein TpsB2 1b : Function from experimental evidences in the studied species t : transporter 7 : Outer membrane protein 2018-01-18 16:04:07 no 15546669, 16472308, 17873034 Belongs to a family of outer membrane proteins, encoded by genes generically designated tpsB, that transport the TpsA proteins across the outer membrane during a process known as two-partner secretion (TPS). 1 vladimir 0.278524 0.2332 0.247204 0.241051 0.480425 0.519575 0.256711 0.236577 0.312081 0.194631 0.548658 0.451342 0.328859 0.218121 0.216443 0.236577 0.434564 0.565436 0.25 0.244966 0.213087 0.291946 0.458054 0.541946 0.592901 66686.42 -0.542017 0.309244 0.489076 0.179832 0.127731 0.517647 0.482353 0.242017 0.142857 0.09916 9.154869 9.408403 NMV_0601 2191563 CDS -3 595113 596402 1290 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:17:05 no 3 vladimir 0.296651 0.1922 0.229665 0.281499 0.42185 0.57815 0.272727 0.184211 0.313397 0.229665 0.497608 0.502392 0.366029 0.19378 0.155502 0.284689 0.349282 0.650718 0.251196 0.198565 0.220096 0.330144 0.41866 0.58134 0.557303 47992.48 -0.394005 0.247002 0.448441 0.203837 0.148681 0.522782 0.477218 0.278177 0.136691 0.141487 5.355904 9.549161 NMV_0602 2191564 CDS -3 596529 596993 465 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 12:25:58 no 3 vladimir 0.303226 0.2129 0.212903 0.270968 0.425806 0.574194 0.264516 0.225806 0.309677 0.2 0.535484 0.464516 0.374194 0.187097 0.180645 0.258065 0.367742 0.632258 0.270968 0.225806 0.148387 0.354839 0.374194 0.625806 0.540543 17575.895 -0.475974 0.233766 0.525974 0.220779 0.149351 0.538961 0.461039 0.233766 0.103896 0.12987 4.756157 9.707792 NMV_0603 2191565 CDS -1 597395 598807 1413 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:17:31 no Belongs to the Fic (filamentation induced by cAMP) family of proteins, Fic being involved in the synthesis of PAB or folate. 1 vladimir 0.312821 0.2308 0.21978 0.23663 0.450549 0.549451 0.320879 0.204396 0.283516 0.191209 0.487912 0.512088 0.378022 0.193407 0.147253 0.281319 0.340659 0.659341 0.23956 0.294506 0.228571 0.237363 0.523077 0.476923 0.598314 52351.825 -0.442952 0.240088 0.420705 0.209251 0.136564 0.506608 0.493392 0.286344 0.15859 0.127753 7.350609 9.169604 NMV_0604 2191566 CDS -2 598942 599133 192 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:26:21 no 3 vladimir 0.322917 0.1771 0.140625 0.359375 0.317708 0.682292 0.4375 0.171875 0.09375 0.296875 0.265625 0.734375 0.265625 0.1875 0.140625 0.40625 0.328125 0.671875 0.265625 0.171875 0.1875 0.375 0.359375 0.640625 0.489701 7179.36 0.38254 0.206349 0.460317 0.31746 0.126984 0.603175 0.396825 0.142857 0.126984 0.015873 9.925194 7.777778 NMV_0605 2191567 CDS +2 599180 599542 363 validated/Curated partial truncated IS605 family transposase (internal fragment) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-09 19:24:04 no 3 vladimir 0.330579 0.2314 0.212121 0.225895 0.443526 0.556474 0.355372 0.214876 0.264463 0.165289 0.479339 0.520661 0.363636 0.198347 0.181818 0.256198 0.380165 0.619835 0.272727 0.280992 0.190083 0.256198 0.471074 0.528926 0.492601 13510.095 -0.3675 0.291667 0.458333 0.233333 0.083333 0.491667 0.508333 0.266667 0.191667 0.075 9.713493 9.691667 NMV_0608 2191570 CDS -2 599989 600183 195 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:26:40 no 1 vladimir 0.307692 0.1641 0.235897 0.292308 0.4 0.6 0.323077 0.153846 0.276923 0.246154 0.430769 0.569231 0.353846 0.153846 0.153846 0.338462 0.307692 0.692308 0.246154 0.184615 0.276923 0.292308 0.461538 0.538462 0.570199 7422.375 -0.334375 0.234375 0.40625 0.21875 0.125 0.5 0.5 0.3125 0.171875 0.140625 8.202217 8.265625 NMV_0610 2191572 CDS -3 600489 600833 345 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:26:51 no 3 vladimir 0.350725 0.2145 0.182609 0.252174 0.397101 0.602899 0.373913 0.226087 0.182609 0.217391 0.408696 0.591304 0.33913 0.217391 0.191304 0.252174 0.408696 0.591304 0.33913 0.2 0.173913 0.286957 0.373913 0.626087 0.427355 13091.885 -0.565789 0.280702 0.438596 0.210526 0.096491 0.473684 0.526316 0.280702 0.245614 0.035088 10.905403 9.236842 NMV_0611 2191573 CDS -3 601077 601514 438 validated/Curated no putative VapD-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-23 15:18:03 no Contains a domain found in bacterial proteins associated with virulence, such as the VapD protein. 3 vladimir 0.319635 0.2032 0.196347 0.280822 0.399543 0.600457 0.308219 0.205479 0.280822 0.205479 0.486301 0.513699 0.40411 0.157534 0.157534 0.280822 0.315068 0.684932 0.246575 0.246575 0.150685 0.356164 0.39726 0.60274 0.598554 16729.15 -0.416552 0.255172 0.42069 0.213793 0.137931 0.489655 0.510345 0.248276 0.117241 0.131034 5.159264 9.4 NMV_0614 2191576 CDS -1 602420 603385 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:06:08 no Belongs to the IS30 family. 2 vladimir 0.324017 0.3075 0.204969 0.163561 0.512422 0.487578 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.385093 0.173913 0.223602 0.217391 0.397516 0.602484 0.242236 0.453416 0.177019 0.127329 0.630435 0.369565 0.573852 38005.09 -0.914953 0.249221 0.392523 0.193146 0.130841 0.417445 0.582555 0.327103 0.23676 0.090343 10.12397 9.716511 NMV_0617 2191579 CDS +2 604037 604360 324 validated/Curated partial truncated IS150 group transposase (C-terminal third of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 13:00:31 no 1 vladimir 0.30787 0.2014 0.243056 0.247685 0.444444 0.555556 0.298611 0.1875 0.284722 0.229167 0.472222 0.527778 0.381944 0.152778 0.180556 0.284722 0.333333 0.666667 0.243056 0.263889 0.263889 0.229167 0.527778 0.472222 0.596212 16521.57 -0.447552 0.237762 0.426573 0.230769 0.118881 0.51049 0.48951 0.300699 0.202797 0.097902 9.59536 9.496503 NMV_0618 2191580 fCDS -1 604733 604816 84 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:06:26 no Belongs to the IS5 family. 2 vladimir 0.238095 0.2857 0.297619 0.178571 0.583333 0.416667 0.321429 0.214286 0.321429 0.142857 0.535714 0.464286 0.25 0.321429 0.178571 0.25 0.5 0.5 0.142857 0.321429 0.392857 0.142857 0.714286 0.285714 0.526338 2750.14 0.444444 0.444444 0.592593 0.222222 0.037037 0.62963 0.37037 0.148148 0.148148 0 10.062447 8.481481 NMV_0619 2191581 fCDS -2 604843 605619 777 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:06:39 no Belongs to the IS5 family. 2 vladimir 0.295739 0.2995 0.214286 0.190476 0.513784 0.486216 0.289474 0.285714 0.270677 0.154135 0.556391 0.443609 0.379699 0.191729 0.176692 0.25188 0.368421 0.631579 0.218045 0.421053 0.195489 0.165414 0.616541 0.383459 0.650417 30573.67 -0.614717 0.249057 0.407547 0.211321 0.116981 0.475472 0.524528 0.30566 0.173585 0.132075 7.877937 9.143396 NMV_0621 2191583 CDS -2 605698 605847 150 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:18:27 no 1 vladimir 0.3 0.1867 0.3 0.213333 0.486667 0.513333 0.38 0.08 0.38 0.16 0.46 0.54 0.3 0.2 0.22 0.28 0.42 0.58 0.22 0.28 0.3 0.2 0.58 0.42 0.54981 5481.2 -0.161224 0.306122 0.469388 0.22449 0.081633 0.571429 0.428571 0.306122 0.183673 0.122449 9.429802 9.673469 NMV_0622 2191584 CDS -2 605848 606144 297 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 12:28:39 no 1 vladimir 0.272727 0.2323 0.232323 0.262626 0.464646 0.535354 0.252525 0.242424 0.323232 0.181818 0.565657 0.434343 0.343434 0.20202 0.161616 0.292929 0.363636 0.636364 0.222222 0.252525 0.212121 0.313131 0.464646 0.535354 0.535094 11336.315 -0.455102 0.214286 0.5 0.214286 0.153061 0.510204 0.489796 0.285714 0.153061 0.132653 6.053169 9.867347 NMV_0623 2191585 CDS -3 606135 606488 354 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-02-14 12:28:51 no 2 vladimir 0.288136 0.2373 0.240113 0.234463 0.477401 0.522599 0.305085 0.20339 0.262712 0.228814 0.466102 0.533898 0.271186 0.186441 0.220339 0.322034 0.40678 0.59322 0.288136 0.322034 0.237288 0.152542 0.559322 0.440678 0.54232 13752.78 -0.070085 0.25641 0.358974 0.213675 0.153846 0.598291 0.401709 0.25641 0.162393 0.094017 9.583076 9.367521 NMV_0624 2191586 CDS +1 606724 608151 1428 validated/Curated no putative FrpA/C secretion adaptor protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-03-23 15:19:32 no Type I secretion is an ABC transporter that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium. This entry represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This entry selects a group of sequences closely related to HlyD. 1 vladimir 0.238095 0.2248 0.329832 0.207283 0.554622 0.445378 0.22479 0.237395 0.378151 0.159664 0.615546 0.384454 0.342437 0.243697 0.144958 0.268908 0.388655 0.611345 0.147059 0.193277 0.466387 0.193277 0.659664 0.340336 0.598927 52649.55 -0.322105 0.296842 0.494737 0.225263 0.084211 0.503158 0.496842 0.250526 0.134737 0.115789 6.891426 9.138947 NMV_0625 2191587 CDS +3 608238 609623 1386 validated/Curated no putative TolC outer membrane protein 3 : Putative function from multiple computational evidences t : transporter 7 : Outer membrane protein 2020-04-20 19:55:56 no Belongs to the OEP family (Outer membrane efflux Protein) that form trimeric channels allowing export of a variety of substrates in Gram negative bacteria. 1 vladimir 0.269231 0.2749 0.247863 0.207977 0.522792 0.477208 0.209402 0.271368 0.331197 0.188034 0.602564 0.397436 0.358974 0.260684 0.145299 0.235043 0.405983 0.594017 0.239316 0.292735 0.267094 0.200855 0.559829 0.440171 0.593028 52539.15 -0.442612 0.312634 0.45182 0.188437 0.117773 0.509636 0.490364 0.229122 0.12848 0.100642 8.362007 9.605996 NMV_0626 2191588 fCDS -2 609787 610323 537 validated/Curated pseudo IS630 family transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:10:52 no 1 vladimir 0.281145 0.2306 0.228956 0.259259 0.459596 0.540404 0.237374 0.262626 0.272727 0.227273 0.535354 0.464646 0.338384 0.217172 0.161616 0.282828 0.378788 0.621212 0.267677 0.212121 0.252525 0.267677 0.464646 0.535354 0.535743 22873.47 -0.396954 0.243655 0.441624 0.213198 0.147208 0.532995 0.467005 0.253807 0.162437 0.091371 9.559578 9.593909 NMV_0627 2191589 fCDS -3 610323 610547 225 validated/Curated pseudo IS630 family transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:11:07 no 3 vladimir 0.359848 0.2500 0.19697 0.193182 0.44697 0.55303 0.352273 0.295455 0.215909 0.136364 0.511364 0.488636 0.397727 0.238636 0.159091 0.204545 0.397727 0.602273 0.329545 0.215909 0.215909 0.238636 0.431818 0.568182 0.450454 10017.3 -0.814943 0.275862 0.436782 0.183908 0.114943 0.45977 0.54023 0.298851 0.252874 0.045977 10.337593 9.103448 NMV_0628 2191590 CDS -2 610867 613080 2214 validated/Curated no relA GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase; ppGpp synthetase I; (P)ppGpp synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.6.5 GDPPYPHOSKIN-RXN$GTPPYPHOSKIN-RXN PPGPPMET-PWY 2018-01-18 16:08:16 no Catalyses the formation of (p)ppGpp, a regulatory metabolite of the stringent response, in the following reaction: ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate. 2 vladimir 0.257453 0.3365 0.241644 0.164408 0.578139 0.421861 0.252033 0.265583 0.359079 0.123306 0.624661 0.375339 0.333333 0.219512 0.169377 0.277778 0.388889 0.611111 0.186992 0.52439 0.196477 0.092141 0.720867 0.279133 0.694279 82530.37 -0.328087 0.263229 0.483039 0.234735 0.093623 0.5346 0.4654 0.286296 0.151967 0.134328 6.552299 9.38806 NMV_0629 2191591 CDS +2 613328 613969 642 validated/Curated no grxB glutaredoxin 2 (Grx2) 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 2 : Cytoplasmic 1.6.15.2 : Thioredoxin, glutaredoxin ; 2018-01-18 16:08:43 no Highly abundant glutaredoxin, which unlike the other two E. coli glutaredoxins appears to be unable to reduce ribonucleotide reductase and may therefore have more to do with resistance to redox stress. 1 vladimir 0.26324 0.2150 0.297508 0.224299 0.512461 0.487539 0.271028 0.182243 0.38785 0.158879 0.570093 0.429907 0.327103 0.163551 0.182243 0.327103 0.345794 0.654206 0.191589 0.299065 0.32243 0.186916 0.621495 0.378505 0.635752 23765.44 -0.150704 0.239437 0.483568 0.239437 0.098592 0.586854 0.413146 0.276995 0.131455 0.14554 5.207436 9.633803 NMV_0630 2191592 CDS +2 614306 614809 504 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-02-14 12:38:00 no 3 vladimir 0.289683 0.1468 0.156746 0.406746 0.303571 0.696429 0.321429 0.125 0.196429 0.357143 0.321429 0.678571 0.279762 0.142857 0.14881 0.428571 0.291667 0.708333 0.267857 0.172619 0.125 0.434524 0.297619 0.702381 0.503496 19853.07 0.59521 0.209581 0.359281 0.269461 0.227545 0.688623 0.311377 0.167665 0.107784 0.05988 8.980766 8.766467 NMV_0632 2191594 CDS +2 614945 615745 801 validated/Curated no putative heavy metal transport protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-18 16:09:09 no Contains a conserved domain, termed Heavy-Metal-Associated (HMA), found in a number of heavy metal transport or detoxification proteins, which contains two conserved cysteines that are probably involved in metal binding. 3 vladimir 0.292135 0.1610 0.213483 0.333333 0.374532 0.625468 0.359551 0.146067 0.277154 0.217228 0.423221 0.576779 0.280899 0.168539 0.116105 0.434457 0.284644 0.715356 0.235955 0.168539 0.247191 0.348315 0.41573 0.58427 0.520491 29955.455 0.640602 0.233083 0.417293 0.338346 0.112782 0.62406 0.37594 0.195489 0.101504 0.093985 5.966759 8.451128 NMV_0633 2191595 CDS -2 615664 615993 330 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:20:03 no 3 vladimir 0.336364 0.1758 0.190909 0.29697 0.366667 0.633333 0.372727 0.154545 0.227273 0.245455 0.381818 0.618182 0.318182 0.218182 0.145455 0.318182 0.363636 0.636364 0.318182 0.154545 0.2 0.327273 0.354545 0.645455 0.526001 12414.91 -0.241284 0.256881 0.477064 0.211009 0.12844 0.522936 0.477064 0.229358 0.146789 0.082569 9.561821 8.807339 NMV_0634 2191596 CDS -3 616197 616835 639 validated/Curated no putative metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-18 16:09:30 no Belongs to the MEROPS peptidase family M50 (S2P protease family, clan MM). 1 vladimir 0.159624 0.2801 0.28169 0.27856 0.561815 0.438185 0.244131 0.267606 0.295775 0.192488 0.56338 0.43662 0.164319 0.244131 0.164319 0.42723 0.408451 0.591549 0.070423 0.328638 0.384977 0.215962 0.713615 0.286385 0.660907 23599.375 0.839151 0.254717 0.476415 0.330189 0.136792 0.745283 0.254717 0.108491 0.066038 0.042453 9.459389 9.070755 NMV_0636 2191598 CDS +2 617090 617932 843 validated/Curated no tonB protein TonB 2a : Function from experimental evidences in other organisms m : membrane component 6 : Inner membrane-associated 2018-01-18 16:10:21 no Transduces energy from the cytoplasmic membrane to specific energy-requiring processes in the outer-membrane, resulting in the release into the periplasm of ligands bound by these outer-membrane proteins. Required for heme utilization and virulence. The neighbouring accessory proteins ExbB and ExbD seem to form a complex with TonB. 1 vladimir 0.263345 0.2432 0.310795 0.182681 0.553974 0.446026 0.238434 0.220641 0.437722 0.103203 0.658363 0.341637 0.345196 0.284698 0.177936 0.192171 0.462633 0.537367 0.206406 0.224199 0.316726 0.252669 0.540925 0.459075 0.606754 29257.625 -0.751071 0.303571 0.592857 0.157143 0.057143 0.546429 0.453571 0.296429 0.15 0.146429 5.810921 9.060714 NMV_0637 2191599 CDS +1 617998 618660 663 validated/Curated no exbB biopolymer transport ExbB protein 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.2.C.1 : TonB Family of Auxiliary Proteins for Energization of OMR-mediated Transport ; 2018-01-18 16:11:11 no Is involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB. 2 vladimir 0.20362 0.2443 0.309201 0.242836 0.553545 0.446456 0.253394 0.21267 0.348416 0.18552 0.561086 0.438914 0.248869 0.221719 0.171946 0.357466 0.393665 0.606335 0.108597 0.298643 0.40724 0.18552 0.705882 0.294118 0.637856 24143.385 0.352273 0.290909 0.490909 0.286364 0.090909 0.631818 0.368182 0.190909 0.118182 0.072727 9.477226 9.390909 NMV_0638 2191600 CDS +3 618663 619097 435 validated/Curated no exbD biopolymer transport ExbD protein 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 2018-03-23 15:20:42 no Is involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. 1 vladimir 0.271264 0.2299 0.287356 0.211494 0.517241 0.482759 0.303448 0.165517 0.4 0.131034 0.565517 0.434483 0.337931 0.262069 0.096552 0.303448 0.358621 0.641379 0.172414 0.262069 0.365517 0.2 0.627586 0.372414 0.694504 15513.065 -0.085417 0.291667 0.555556 0.243056 0.055556 0.548611 0.451389 0.236111 0.097222 0.138889 4.639839 9.201389 NMV_0640 2191602 CDS -1 619784 620212 429 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:21:02 no 2 vladimir 0.263403 0.3287 0.237762 0.170163 0.566434 0.433566 0.202797 0.314685 0.356643 0.125874 0.671329 0.328671 0.335664 0.216783 0.188811 0.258741 0.405594 0.594406 0.251748 0.454545 0.167832 0.125874 0.622378 0.377622 0.707309 16227.855 -0.465493 0.253521 0.43662 0.211268 0.098592 0.521127 0.478873 0.295775 0.15493 0.140845 6.104225 10.28169 NMV_0641 2191603 CDS -3 620277 622025 1749 validated/Curated no putative metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 15:21:20 no Part of a group of metallopeptidases belonging to the MEROPS peptidase family M61 (glycyl aminopeptidase family, clan MA(E)). 2 vladimir 0.248714 0.2876 0.230417 0.233276 0.51801 0.48199 0.240137 0.233276 0.305317 0.221269 0.538593 0.461407 0.298456 0.250429 0.173242 0.277873 0.423671 0.576329 0.207547 0.379074 0.212693 0.200686 0.591767 0.408233 0.640321 65738.095 -0.1689 0.302405 0.477663 0.213058 0.158076 0.553265 0.446735 0.247423 0.127148 0.120275 5.604774 9.183849 NMV_0642 2191604 CDS +2 622352 623785 1434 validated/Curated no ccoN cytochrome c oxidase polypeptide I 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 1.9.3.1 CYTOCHROME-C-OXIDASE-RXN PWY-3781 2018-01-29 18:27:03 no Cytochrome cbb3 oxidases consist of four subunits: CcoN, CcoO, CcoP and CcoQ. The catalytic core is comprised of subunits CcoN, CcoO and CcoP, where CcoN acts as the catalytic subunit and CcoO and CcoP are membrane-bound mono- and di-haem cytochromes c, respectively. The CcoQ subunit protects the core complex from proteolytic degradation in the presence of oxygen. 1 vladimir 0.194329 0.2552 0.258645 0.29184 0.513831 0.486169 0.253112 0.176349 0.323651 0.246888 0.5 0.5 0.215768 0.232365 0.182573 0.369295 0.414938 0.585062 0.114108 0.356846 0.26971 0.259336 0.626556 0.373444 0.765895 53927.24 0.559252 0.307692 0.488565 0.259875 0.195426 0.702703 0.297297 0.130977 0.089397 0.04158 9.068886 9.272349 NMV_0643 2191605 CDS +1 623812 624423 612 validated/Curated no ccoO cytochrome c oxidase polypeptide II 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 11 : Membrane 1.3.6 : Aerobic respiration ; 1.9.3.1 CYTOCHROME-C-OXIDASE-RXN PWY-3781 2018-01-29 18:26:46 no Cytochrome cbb3 oxidases consist of four subunits: CcoN, CcoO, CcoP and CcoQ. The catalytic core is comprised of subunits CcoN, CcoO and CcoP, where CcoN acts as the catalytic subunit and CcoO and CcoP are membrane-bound mono- and di-haem cytochromes c, respectively. The CcoQ subunit protects the core complex from proteolytic degradation in the presence of oxygen. 1 vladimir 0.227124 0.2451 0.276144 0.251634 0.521242 0.478758 0.20098 0.235294 0.387255 0.176471 0.622549 0.377451 0.308824 0.240196 0.166667 0.284314 0.406863 0.593137 0.171569 0.259804 0.27451 0.294118 0.534314 0.465686 0.712548 22528.03 -0.164532 0.26601 0.517241 0.241379 0.108374 0.596059 0.403941 0.251232 0.142857 0.108374 8.50396 9.842365 NMV_0644 2191606 CDS +2 624428 624598 171 validated/Curated no ccoQ cytochrome c oxidase polypeptide IV 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 1 : Unknown 1.3.6 : Aerobic respiration ; 1.9.3.1 CYTOCHROME-C-OXIDASE-RXN PWY-3781 2018-01-29 18:26:25 no Cytochrome cbb3 oxidases consist of four subunits: CcoN, CcoO, CcoP and CcoQ. The catalytic core is comprised of subunits CcoN, CcoO and CcoP, where CcoN acts as the catalytic subunit and CcoO and CcoP are membrane-bound mono- and di-haem cytochromes c, respectively. The CcoQ subunit protects the core complex from proteolytic degradation in the presence of oxygen. 1 vladimir 0.333333 0.1871 0.19883 0.280702 0.385965 0.614035 0.403509 0.140351 0.263158 0.192982 0.403509 0.596491 0.421053 0.087719 0.157895 0.333333 0.245614 0.754386 0.175439 0.333333 0.175439 0.315789 0.508772 0.491228 0.661397 6686.355 -0.3375 0.160714 0.446429 0.232143 0.142857 0.5 0.5 0.267857 0.142857 0.125 8.119118 9.660714 NMV_0645 2191607 CDS +1 624622 625719 1098 validated/Curated no ccoP cytochrome c oxidase polypeptide III 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 11 : Membrane 1.3.6 : Aerobic respiration ; 1.9.3.1 CYTOCHROME-C-OXIDASE-RXN PWY-3781 2018-01-29 18:27:45 no Cytochrome cbb3 oxidases consist of four subunits: CcoN, CcoO, CcoP and CcoQ. The catalytic core is comprised of subunits CcoN, CcoO and CcoP, where CcoN acts as the catalytic subunit and CcoO and CcoP are membrane-bound mono- and di-haem cytochromes c, respectively. The CcoQ subunit protects the core complex from proteolytic degradation in the presence of oxygen. 1 vladimir 0.269581 0.2450 0.263206 0.222222 0.508197 0.491803 0.251366 0.193989 0.379781 0.174863 0.57377 0.426229 0.34153 0.26776 0.180328 0.210383 0.448087 0.551913 0.215847 0.273224 0.229508 0.281421 0.502732 0.497268 0.763403 40009.66 -0.433151 0.323288 0.528767 0.161644 0.126027 0.580822 0.419178 0.246575 0.126027 0.120548 5.819893 9.178082 NMV_0646 2191608 CDS +1 625828 625953 126 validated/Curated partial truncated cytochrome c (C-terminal 15% of the protein) 5 : Unknown function c : carrier 1 : Unknown 2008-02-14 13:28:42 no 1 vladimir 0.285714 0.2143 0.285714 0.214286 0.5 0.5 0.261905 0.119048 0.452381 0.166667 0.571429 0.428571 0.404762 0.166667 0.190476 0.238095 0.357143 0.642857 0.190476 0.357143 0.214286 0.238095 0.571429 0.428571 0.797862 4391.69 -0.592683 0.317073 0.560976 0.146341 0.121951 0.536585 0.463415 0.317073 0.170732 0.146341 6.033623 9.365854 NMV_0647 2191609 CDS +1 626155 627564 1410 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-14 13:28:53 no 1 vladimir 0.194326 0.2277 0.312766 0.265248 0.540426 0.459574 0.261702 0.214894 0.33617 0.187234 0.551064 0.448936 0.219149 0.229787 0.208511 0.342553 0.438298 0.561702 0.102128 0.238298 0.393617 0.265957 0.631915 0.368085 0.646993 52365.28 0.238166 0.28145 0.507463 0.26226 0.1258 0.648188 0.351812 0.183369 0.10661 0.076759 9.177834 9.249467 NMV_0648 2191610 CDS +2 627665 630874 3210 validated/Curated no recC exodeoxyribonuclease V gamma chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.11.5 RXN0-2605 2018-01-22 15:34:00 no Is a multisubunit enzyme comprised of the proteins RecB, RecC and RecD, which plays an important role in homologous genetic recombination, repair of double strand DNA breaks, resistance to UV irradiation and chemical DNA-damage. The enzyme catalyses hydrolysis of single-stranded (ss) DNA or double-stranded (ds) DNA and unwinding of the ends of dsDNA. Its nuclease activity is controlled by Chi sites (5' G-C-T-G-G-T-G-G 3') in such a way that the enzyme produces a potent single-stranded DNA substrate for homologous pairing by RecA and single-stranded DNA binding proteins. 2 vladimir 0.238006 0.2813 0.27134 0.209346 0.552648 0.447352 0.200935 0.27757 0.342991 0.178505 0.620561 0.379439 0.309346 0.217757 0.184112 0.288785 0.401869 0.598131 0.203738 0.348598 0.286916 0.160748 0.635514 0.364486 0.619755 120700.86 -0.258653 0.261927 0.450889 0.218896 0.117867 0.563143 0.436857 0.248831 0.115061 0.13377 5.046043 9.322732 NMV_0649 2191611 CDS -3 630942 632510 1569 validated/Curated no putative p-aminobenzoyl-glutamate transport protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.68 : The p-Aminobenzoyl-glutamate Transporter (AbgT) Family ; 2020-02-21 16:06:00 no 12493784 Key for aminobenzoyl-glutamate utilisation. It catalyses the concentration-dependent uptake of p-aminobenzoyl-glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyse cleavage into p-aminobenzoate and glutamate. 1 vladimir 0.196303 0.2314 0.251115 0.321224 0.482473 0.517527 0.240918 0.166348 0.342256 0.250478 0.508604 0.491396 0.181644 0.260038 0.152964 0.405354 0.413002 0.586998 0.166348 0.267686 0.258126 0.307839 0.525813 0.474187 0.641481 56180.245 0.792529 0.316092 0.51341 0.308429 0.130268 0.704981 0.295019 0.128352 0.070881 0.057471 6.837379 8.454023 NMV_0651 2191613 CDS +3 632799 633056 258 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:22:03 no 3 vladimir 0.414729 0.0891 0.193798 0.302326 0.282946 0.717054 0.348837 0.081395 0.337209 0.232558 0.418605 0.581395 0.523256 0.104651 0.046512 0.325581 0.151163 0.848837 0.372093 0.081395 0.197674 0.348837 0.27907 0.72093 0.607118 10311.23 -0.581176 0.105882 0.364706 0.235294 0.164706 0.470588 0.529412 0.364706 0.141176 0.223529 4.524269 9.964706 NMV_0652 2191614 CDS -1 633335 633967 633 validated/Curated no mtrR HTH-type transcriptional regulator MtrR 1c : Function from experimental evidences in the studied genus r : regulator 2 : Cytoplasmic 2018-01-18 16:19:12 no 8196548 Putative repressor of the mtrC gene. Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents. 2 vladimir 0.279621 0.2733 0.244866 0.202212 0.518167 0.481833 0.28436 0.194313 0.327014 0.194313 0.521327 0.478673 0.36019 0.203791 0.151659 0.28436 0.35545 0.64455 0.194313 0.421801 0.255924 0.127962 0.677725 0.322275 0.71241 24372.995 -0.338095 0.257143 0.409524 0.209524 0.138095 0.504762 0.495238 0.328571 0.17619 0.152381 6.268181 9.47619 NMV_0653 2191615 CDS +3 634371 635609 1239 validated/Curated no mtrC membrane fusion protein MtrC 1c : Function from experimental evidences in the studied genus m : membrane component 6 : Inner membrane-associated 2018-01-18 16:19:47 no 8196548 Belongs to the membrane fusion protein (MFP) family. MFP are lipoproteins, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents. 1 vladimir 0.225182 0.2663 0.309927 0.198547 0.576271 0.423729 0.227603 0.210654 0.450363 0.11138 0.661017 0.338983 0.271186 0.322034 0.152542 0.254237 0.474576 0.525424 0.176755 0.266344 0.326877 0.230024 0.59322 0.40678 0.696217 43009.085 -0.03932 0.376214 0.597087 0.218447 0.046117 0.580097 0.419903 0.199029 0.101942 0.097087 7.979408 9.548544 NMV_0654 2191616 CDS +2 635621 638824 3204 validated/Curated no mtrD drug efflux transport protein MtrD 1c : Function from experimental evidences in the studied genus t : transporter 5 : Inner membrane protein 2018-01-18 16:20:03 no 9245801 Belongs to a family of cytoplasmic membrane proteins, termed resistance/nodulation/division (RND) proteins, which function as energy-dependent transporters of antibacterial agents. 1 vladimir 0.213795 0.2556 0.283396 0.247191 0.539014 0.460986 0.279963 0.180712 0.367978 0.171348 0.548689 0.451311 0.231273 0.264045 0.162921 0.34176 0.426966 0.573034 0.13015 0.322097 0.319288 0.228464 0.641386 0.358614 0.707127 113988.19 0.310778 0.343955 0.546392 0.252109 0.089972 0.610122 0.389878 0.163074 0.084349 0.078725 6.305885 8.927835 NMV_0655 2191617 CDS +2 638879 640282 1404 validated/Curated no mtrE outer-membrane lipoprotein MtrE 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-18 16:20:36 no 9245802 Member of this group are outer-membrane lipoproteins from the NodT family of the RND (Resistance-Nodulation-cell Division) type efflux systems. These proteins work with an inner-membrane ABC transporter ATPase and an adapter called a membrane fusion protein. 2 vladimir 0.236467 0.3048 0.263533 0.195157 0.568376 0.431624 0.235043 0.217949 0.380342 0.166667 0.598291 0.401709 0.294872 0.286325 0.17735 0.241453 0.463675 0.536325 0.179487 0.410256 0.232906 0.17735 0.643162 0.356838 0.707288 50404.97 -0.21349 0.366167 0.531049 0.203426 0.083512 0.539615 0.460385 0.235546 0.126338 0.109208 8.650826 9.092077 NMV_0656 2191618 CDS -1 640394 640540 147 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 13:32:22 no 2 vladimir 0.272109 0.3401 0.190476 0.197279 0.530612 0.469388 0.346939 0.22449 0.22449 0.204082 0.44898 0.55102 0.326531 0.244898 0.163265 0.265306 0.408163 0.591837 0.142857 0.55102 0.183673 0.122449 0.734694 0.265306 0.873387 5578.245 -0.520833 0.270833 0.479167 0.1875 0.1875 0.5 0.5 0.291667 0.229167 0.0625 10.112648 9.520833 NMV_0657 2191619 CDS -2 640567 640794 228 validated/Curated no putative L-lactate permease-related protein 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-18 16:21:20 no Is homologous ot the N-terminal 20% of many L-lactate permeases. 2 vladimir 0.186667 0.2700 0.263333 0.28 0.533333 0.466667 0.2 0.26 0.29 0.25 0.55 0.45 0.2 0.26 0.19 0.35 0.45 0.55 0.16 0.29 0.31 0.24 0.6 0.4 0.584332 11115.79 0.548485 0.323232 0.464646 0.232323 0.181818 0.717172 0.282828 0.131313 0.10101 0.030303 9.410042 9.555556 NMV_0658 2191620 CDS +1 641401 642180 780 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-18 16:21:34 no Belongs to the helix-turn-helix (HTH) GntR family of transcription regulation. 1 vladimir 0.234615 0.2077 0.332051 0.225641 0.539744 0.460256 0.211538 0.226923 0.365385 0.196154 0.592308 0.407692 0.357692 0.173077 0.207692 0.261538 0.380769 0.619231 0.134615 0.223077 0.423077 0.219231 0.646154 0.353846 0.595781 29493.09 -0.525483 0.254826 0.447876 0.212355 0.111969 0.498069 0.501931 0.305019 0.158301 0.146718 5.887077 9.718147 NMV_0659 2191621 CDS -3 642366 642623 258 validated/Curated partial truncated putative acetyltransferase (N-terminal half of the protein) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 15:23:10 no 1 vladimir 0.282946 0.1550 0.282946 0.27907 0.437984 0.562016 0.209302 0.197674 0.395349 0.197674 0.593023 0.406977 0.348837 0.139535 0.162791 0.348837 0.302326 0.697674 0.290698 0.127907 0.290698 0.290698 0.418605 0.581395 0.521148 10067.15 -0.112941 0.164706 0.388235 0.270588 0.129412 0.564706 0.435294 0.317647 0.117647 0.2 4.437859 9.494118 NMV_0660 2191622 CDS -2 642667 643035 369 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-02-14 13:33:18 no 3 vladimir 0.338753 0.1409 0.176152 0.344173 0.317073 0.682927 0.300813 0.146341 0.260163 0.292683 0.406504 0.593496 0.422764 0.146341 0.105691 0.325203 0.252033 0.747967 0.292683 0.130081 0.162602 0.414634 0.292683 0.707317 0.453019 14306.725 -0.345082 0.196721 0.418033 0.229508 0.155738 0.516393 0.483607 0.262295 0.114754 0.147541 4.773247 8.92623 NMNmiscRNA0173 54921105 misc_RNA +1 643045 643163 119 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:44:56 28334889 Function unknown. vladimir NMV_0661 2191623 CDS -2 643183 644517 1335 validated/Curated no gdhA NADP-specific glutamate dehydrogenase (NADP-GDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.5.1.1 : Glutamate ; 1.4.1.4 GLUTDEHYD-RXN GLUTSYNIII-PWY$PWY-5913 2018-01-30 12:33:54 no Is involved in glutamate biosynthesis and catalyses the following reaction: L-glutamate + H(2)O + NADP(+) <=> 2-oxoglutarate + NH(3) + NADPH. 2 vladimir 0.24794 0.3026 0.257678 0.19176 0.5603 0.4397 0.233708 0.208989 0.393258 0.164045 0.602247 0.397753 0.314607 0.213483 0.188764 0.283146 0.402247 0.597753 0.195506 0.485393 0.191011 0.12809 0.676404 0.323596 0.805305 48474.185 -0.188964 0.313063 0.513514 0.202703 0.103604 0.578829 0.421171 0.220721 0.11036 0.11036 5.804939 9.648649 NMV_0663 2191625 CDS +3 644940 645734 795 validated/Curated no thyA thymidylate synthase (TS; TSase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.1.1.45 THYMIDYLATESYN-RXN 1CMET2-PWY$P1-PWY$PWY0-166 2018-01-18 16:22:40 no Catalyses the following reaction: 5,10-methylenetetrahydrofolate + dUMP <=> dihydrofolate + dTMP. Provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during one-carbon transfer. 1 vladimir 0.228931 0.2553 0.269182 0.246541 0.524528 0.475472 0.222642 0.226415 0.324528 0.226415 0.550943 0.449057 0.34717 0.196226 0.154717 0.301887 0.350943 0.649057 0.116981 0.343396 0.328302 0.211321 0.671698 0.328302 0.686729 30275.465 -0.287879 0.227273 0.458333 0.215909 0.155303 0.568182 0.431818 0.272727 0.143939 0.128788 5.925423 9.42803 NMV_0664 2191626 fCDS +2 645743 646024 282 validated/Curated partial truncated putative Tat-translocated NosX-like protein (pseudogene part 1) 5 : Unknown function e : enzyme 1 : Unknown 2018-01-18 16:23:02 no NosX is required for nitrous oxide reduction. This protein has a typical twin-arginine dependent signal sequence. 1 vladimir 0.202128 0.2128 0.336879 0.248227 0.549645 0.450355 0.180851 0.180851 0.468085 0.170213 0.648936 0.351064 0.276596 0.234043 0.191489 0.297872 0.425532 0.574468 0.148936 0.223404 0.351064 0.276596 0.574468 0.425532 0.668282 10221.3 -0.180645 0.268817 0.537634 0.215054 0.096774 0.591398 0.408602 0.301075 0.172043 0.129032 9.698753 9.784946 NMV_0665 2191627 fCDS +3 645999 646340 342 validated/Curated partial truncated putative Tat-translocated NosX-like protein (pseudogene part 2) 5 : Unknown function e : enzyme 1 : Unknown 2018-01-18 16:23:22 no NosX is required for nitrous oxide reduction. This protein has a typical twin-arginine dependent signal sequence. 1 vladimir 0.221154 0.2388 0.30609 0.233974 0.544872 0.455128 0.283654 0.230769 0.25 0.235577 0.480769 0.519231 0.230769 0.240385 0.259615 0.269231 0.5 0.5 0.149038 0.245192 0.408654 0.197115 0.653846 0.346154 0.532451 23819.95 -0.363285 0.299517 0.478261 0.198068 0.111111 0.531401 0.468599 0.280193 0.193237 0.086957 10.340157 9.256039 NMV_0666 2191628 CDS -3 646575 647912 1338 validated/Curated no putative sodium-dependent transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-02-14 13:33:55 no 1 vladimir 0.176383 0.2369 0.280269 0.306428 0.51719 0.48281 0.253363 0.168161 0.334081 0.244395 0.502242 0.497758 0.159193 0.257848 0.170404 0.412556 0.428251 0.571749 0.116592 0.284753 0.336323 0.262332 0.621076 0.378924 0.657836 48328.38 0.861348 0.334831 0.505618 0.292135 0.152809 0.710112 0.289888 0.119101 0.074157 0.044944 9.49688 8.251685 NMV_0667 2191629 CDS -1 648299 649363 1065 validated/Curated no rfaK lcsA alpha 1,2 N-acetylglucosamine transferase 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2020-02-19 15:29:49 no 8631701, 8830268 Is involved in the inner core biosynthesis of lipooligosaccharide (LOS). 1 vladimir 0.268545 0.2507 0.228169 0.252582 0.478873 0.521127 0.270423 0.216901 0.309859 0.202817 0.526761 0.473239 0.304225 0.216901 0.16338 0.315493 0.380282 0.619718 0.230986 0.31831 0.211268 0.239437 0.529577 0.470423 0.564961 39925.635 -0.109887 0.274011 0.471751 0.245763 0.121469 0.536723 0.463277 0.271186 0.166667 0.10452 9.106697 9.364407 NMV_0668 2191630 CDS -1 649364 650122 759 validated/Curated no lgtF beta-1,4-glucosyltransferase 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; CELLULOSE-SYNTHASE-UDP-FORMING-RXN PWY-1001 2018-01-18 16:25:34 no 12618369 Attaches the first glucose residue to HepI of LOS. 1 vladimir 0.309618 0.2292 0.218709 0.242424 0.447958 0.552042 0.312253 0.177866 0.304348 0.205534 0.482213 0.517787 0.383399 0.162055 0.177866 0.27668 0.339921 0.660079 0.233202 0.347826 0.173913 0.245059 0.521739 0.478261 0.65996 29441.625 -0.47381 0.234127 0.436508 0.190476 0.174603 0.531746 0.468254 0.297619 0.178571 0.119048 9.037697 9.634921 NMV_tRNA_55 2194870 tRNA -1 650197 650272 76 validated/Curated no Met tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:50:37 no tRNA Met anticodon CAT. vladimir NMV_0669 2191631 CDS -2 650326 651462 1137 validated/Curated no fabB 3-oxoacyl-(acyl-carrier-protein) synthase I (beta-ketoacyl-ACP synthase I; KAS I) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 2.3.1.179 2.3.1.179-RXN$RXN1G-1015$RXN1G-1212$RXN1G-172$RXN1G-202$RXN1G-32$RXN1G-334$RXN1G-374$RXN1G-424$RXN1G-557$RXN1G-580$RXN1G-582$RXN1G-660$RXN1G-79$RXN1G-818$RXN1G-883$RXN1G-89$RXN1G-94 PWY-5973 2018-02-01 22:14:29 no Catalyses the following reaction with the growing fatty acid chain:, (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] <=> (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. 2 vladimir 0.225154 0.2999 0.295515 0.17942 0.595427 0.404573 0.253298 0.205805 0.385224 0.155673 0.591029 0.408971 0.266491 0.261214 0.245383 0.226913 0.506596 0.493404 0.155673 0.432718 0.255937 0.155673 0.688654 0.311346 0.65896 40232.335 -0.260053 0.386243 0.563492 0.169312 0.108466 0.579365 0.420635 0.216931 0.103175 0.113757 5.159157 9.619048 NMV_0670 2191632 CDS -2 652036 653043 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:26:36 no Belongs to the IS5 family. 2 vladimir 0.287698 0.3006 0.223214 0.188492 0.52381 0.47619 0.285714 0.28869 0.267857 0.157738 0.556548 0.443452 0.372024 0.205357 0.178571 0.244048 0.383929 0.616071 0.205357 0.407738 0.223214 0.16369 0.630952 0.369048 0.675318 38481.62 -0.608955 0.268657 0.420896 0.2 0.119403 0.477612 0.522388 0.298507 0.191045 0.107463 9.514824 9.220896 NMV_0671 2191633 CDS -1 653150 653713 564 validated/Curated partial truncated IS1016 group transposase (N-terminal 85% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 13:13:21 no 1 vladimir 0.29368 0.2317 0.240397 0.234201 0.472119 0.527881 0.312268 0.226766 0.304833 0.156134 0.531599 0.468401 0.334572 0.174721 0.226766 0.263941 0.401487 0.598513 0.234201 0.29368 0.189591 0.282528 0.483271 0.516729 0.526758 30680.745 -0.620149 0.253731 0.473881 0.208955 0.115672 0.470149 0.529851 0.317164 0.208955 0.108209 10.065758 9.701493 NMV_0672 2191634 CDS +2 653900 654322 423 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 13:36:55 no 1 vladimir 0.186761 0.2270 0.352246 0.234043 0.579196 0.420804 0.177305 0.184397 0.375887 0.262411 0.560284 0.439716 0.205674 0.312057 0.241135 0.241135 0.553191 0.446809 0.177305 0.184397 0.439716 0.198582 0.624113 0.375887 0.58694 15423.045 -0.029286 0.385714 0.55 0.192857 0.1 0.607143 0.392857 0.207143 0.092857 0.114286 4.99157 10.192857 NMV_0674 2191636 CDS +2 654620 655054 435 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-14 13:37:08 no 1 vladimir 0.165517 0.2322 0.312644 0.289655 0.544828 0.455172 0.172414 0.248276 0.331034 0.248276 0.57931 0.42069 0.193103 0.206897 0.206897 0.393103 0.413793 0.586207 0.131034 0.241379 0.4 0.227586 0.641379 0.358621 0.584259 16516.195 0.622222 0.263889 0.4375 0.291667 0.166667 0.729167 0.270833 0.152778 0.111111 0.041667 9.948799 9.680556 NMV_0675 2191637 CDS +2 655061 655576 516 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-14 13:37:20 no 2 vladimir 0.257752 0.2771 0.232558 0.232558 0.50969 0.49031 0.203488 0.244186 0.337209 0.215116 0.581395 0.418605 0.366279 0.209302 0.19186 0.232558 0.401163 0.598837 0.203488 0.377907 0.168605 0.25 0.546512 0.453488 0.690185 19472.89 -0.504094 0.274854 0.502924 0.169591 0.152047 0.538012 0.461988 0.263158 0.099415 0.163743 4.473106 10.497076 NMV_0676 2191638 CDS +3 655596 657074 1479 validated/Curated no ubiD 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (polyprenyl p-hydroxybenzoate decarboxylase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 4.1.1.98 3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN PWY-6708 2018-01-18 16:27:58 no Catalyses the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol. Is involved in ubiquinone biosynthesis. 1 vladimir 0.240027 0.2786 0.284652 0.196755 0.563218 0.436782 0.243408 0.243408 0.352941 0.160243 0.596349 0.403651 0.318458 0.21501 0.174442 0.292089 0.389452 0.610548 0.158215 0.377282 0.326572 0.137931 0.703854 0.296146 0.704264 55562.015 -0.281301 0.23374 0.495935 0.231707 0.113821 0.587398 0.412602 0.26626 0.138211 0.128049 6.130287 9.780488 NMV_0677 2191639 CDS -2 657139 659253 2115 validated/Curated no putative AsmA-like protein 3 : Putative function from multiple computational evidences m : membrane component 8 : Outer membrane-associated 2018-01-18 16:28:22 no Homologous to the AsmA protein that is involved in the assembly of outer-membrane proteins in E. coli. 2 vladimir 0.262884 0.3239 0.230733 0.182506 0.55461 0.44539 0.300709 0.273759 0.29078 0.134752 0.564539 0.435461 0.312057 0.235461 0.177305 0.275177 0.412766 0.587234 0.175887 0.462411 0.224113 0.137589 0.686525 0.313475 0.64366 77651.725 -0.329545 0.301136 0.507102 0.235795 0.099432 0.50142 0.49858 0.234375 0.133523 0.100852 8.683403 8.545455 NMV_0678 2191640 CDS +1 659344 660237 894 validated/Curated no putative phospho-2-dehydro-3-deoxyheptonate aldolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 2.5.1.54 DAHPSYN-RXN PWY-6164 2018-01-29 22:55:21 no 12743122 Catalysese the following reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O <=> 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. 1 vladimir 0.221477 0.2528 0.319911 0.205817 0.572707 0.427293 0.234899 0.181208 0.432886 0.151007 0.614094 0.385906 0.261745 0.218121 0.238255 0.281879 0.456376 0.543624 0.167785 0.35906 0.288591 0.184564 0.647651 0.352349 0.598711 32186.31 -0.096633 0.326599 0.548822 0.249158 0.084175 0.56229 0.43771 0.282828 0.158249 0.124579 7.299553 9.814815 NMV_0679 2191641 CDS +2 660377 661228 852 validated/Curated no folP dhpS dihydropteroate synthase (DHPS; dihydropteroate pyrophosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 2.5.1.15 H2PTEROATESYNTH-RXN PWY-6614 2018-01-18 16:30:39 no Catalyses the second step in folic acid biosynthesis: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate <=> diphosphate + dihydropteroate. 1 vladimir 0.220657 0.2477 0.333333 0.198357 0.580986 0.419014 0.214789 0.207746 0.443662 0.133803 0.651408 0.348592 0.267606 0.253521 0.183099 0.295775 0.43662 0.56338 0.179577 0.28169 0.373239 0.165493 0.65493 0.34507 0.634367 30267.48 0.04841 0.325088 0.533569 0.24735 0.074205 0.607774 0.392226 0.24735 0.120141 0.127208 5.295341 9.749117 NMV_0680 2191642 CDS +2 661358 662692 1335 validated/Curated no glmM phosphoglucosamine mutase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.2 : Peptidoglycan (murein) ; 6.3 : Surface antigens (ECA, O antigen of LPS) ; 5.4.2.10 5.4.2.10-RXN OANTIGEN-PWY$UDPNAGSYN-PWY 2018-01-30 10:51:49 no Catalyses the following reaction: alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate. 2 vladimir 0.233708 0.2854 0.29588 0.185019 0.581273 0.418727 0.235955 0.195506 0.433708 0.134831 0.629213 0.370787 0.310112 0.220225 0.191011 0.278652 0.411236 0.588764 0.155056 0.440449 0.262921 0.141573 0.703371 0.296629 0.720404 47804.435 -0.133108 0.322072 0.542793 0.22973 0.078829 0.578829 0.421171 0.247748 0.123874 0.123874 5.651558 9.682432 NMV_0681 2191643 CDS +1 662881 663564 684 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms m : membrane component 11 : Membrane 2020-04-23 18:26:30 no Belongs to the DedA family of proteins, which are not functionally characterised. 1 vladimir 0.204678 0.2529 0.295322 0.247076 0.548246 0.451754 0.232456 0.20614 0.350877 0.210526 0.557018 0.442982 0.241228 0.201754 0.197368 0.359649 0.399123 0.600877 0.140351 0.350877 0.337719 0.171053 0.688596 0.311404 0.712539 25548.4 0.37533 0.281938 0.427313 0.251101 0.162996 0.69163 0.30837 0.198238 0.145374 0.052863 10.127815 9.110132 NMV_0682 2191644 CDS +1 663631 664623 993 validated/Curated no putative L-asparaginase I (L-asparagine amidohydrolase I; L-ASNase I) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.3 : Amino acids ; 3.5.1.1 ASPARAGHYD-RXN ASPARAGINE-DEG1-PWY 2020-02-19 13:03:24 no Catalyses the following reaction: L-asparagine + H(2)O <=> L-aspartate + NH(3). Glutaminase, a similar enzyme, catalyses the deaminination of glutamine to glutamic acid and an ammonium ion. 2 vladimir 0.221551 0.3192 0.27291 0.186304 0.592145 0.407855 0.232628 0.256798 0.377643 0.132931 0.634441 0.365559 0.277946 0.253776 0.190332 0.277946 0.444109 0.555891 0.154079 0.44713 0.250755 0.148036 0.697885 0.302115 0.637448 35316.645 0.011515 0.342424 0.551515 0.230303 0.1 0.60303 0.39697 0.178788 0.087879 0.090909 5.35067 9.069697 NMV_0683 2191645 CDS +2 664631 665401 771 validated/Curated no putative metal-dependent deoxyribonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.21.- 2018-01-23 10:59:27 no Belongs to the TatD family of proteins, a large superfamily of metalloenzymes. 2 vladimir 0.226978 0.2996 0.26978 0.203632 0.56939 0.43061 0.252918 0.252918 0.361868 0.132296 0.614786 0.385214 0.276265 0.249027 0.182879 0.291829 0.431907 0.568093 0.151751 0.396887 0.264591 0.18677 0.661479 0.338521 0.652961 28130.225 -0.067578 0.300781 0.492188 0.238281 0.09375 0.570312 0.429688 0.25 0.140625 0.109375 8.289268 9.257812 NMV_0684 2191646 CDS +1 665491 666567 1077 validated/Curated no prfA peptide chain release factor I (RF-1) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-18 16:32:48 no Helps terminate translation at UAA and UAG stop codons. 2 vladimir 0.269266 0.3166 0.261838 0.152275 0.578459 0.421541 0.233983 0.239554 0.417827 0.108635 0.657382 0.342618 0.356546 0.220056 0.172702 0.250696 0.392758 0.607242 0.21727 0.490251 0.194986 0.097493 0.685237 0.314763 0.731144 39678.035 -0.506425 0.290503 0.47486 0.203911 0.072626 0.497207 0.502793 0.329609 0.150838 0.178771 4.991997 9.896648 NMV_0685 2191647 CDS +2 666692 667690 999 validated/Curated no ldhA D-lactate dehydrogenase (D-LDH; fermentative lactate dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.1.28 DLACTDEHYDROGNAD-RXN ALACAT2-PWY$FERMENTATION-PWY 2018-01-19 19:00:05 no Catalyses the following reaction: (R)-lactate + NAD(+) <=> pyruvate + NADH. 1 vladimir 0.236236 0.2282 0.302302 0.233233 0.530531 0.469469 0.273273 0.168168 0.39039 0.168168 0.558559 0.441441 0.315315 0.201201 0.183183 0.3003 0.384384 0.615616 0.12012 0.315315 0.333333 0.231231 0.648649 0.351351 0.683456 36629.335 -0.15 0.301205 0.503012 0.213855 0.108434 0.557229 0.442771 0.28012 0.141566 0.138554 5.663521 9.85241 NMV_0686 2191648 CDS -2 667768 669063 1296 validated/Curated no serS serine-tRNA ligase (seryl-tRNA synthetase; SerRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.11 RXN0-2161$SERINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2020-02-19 13:03:46 no Catalyses the attachment of serine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.271605 0.2816 0.257716 0.189043 0.539352 0.460648 0.24537 0.233796 0.37963 0.141204 0.613426 0.386574 0.351852 0.231481 0.157407 0.259259 0.388889 0.611111 0.217593 0.37963 0.236111 0.166667 0.615741 0.384259 0.769374 47754.06 -0.425522 0.294664 0.489559 0.206497 0.095128 0.508121 0.491879 0.285383 0.141531 0.143852 5.45887 9.675174 NMV_0687 2191649 CDS +3 669144 669752 609 validated/Curated no rppH RNA pyrophosphohydrolase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.1.- RXN0-5510 2018-01-18 16:36:01 no 18202662 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. 2 vladimir 0.215238 0.2819 0.293333 0.209524 0.575238 0.424762 0.165714 0.291429 0.337143 0.205714 0.628571 0.371429 0.337143 0.137143 0.285714 0.24 0.422857 0.577143 0.142857 0.417143 0.257143 0.182857 0.674286 0.325714 0.675199 20918.795 -0.865517 0.201149 0.41954 0.195402 0.16092 0.511494 0.488506 0.333333 0.189655 0.143678 9.264458 10.712644 NMV_0688 2191650 CDS +3 669819 671804 1986 validated/Curated no parE DNA topoisomerase IV subunit B 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.1.1.1 : DNA bending, supercoiling, inversion ; 5.6.2.2 5.99.1.2-RXN 2020-04-21 13:37:05 no Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. 2 vladimir 0.248238 0.3132 0.259819 0.178751 0.573011 0.426989 0.23565 0.243202 0.400302 0.120846 0.643505 0.356495 0.329305 0.205438 0.187311 0.277946 0.392749 0.607251 0.179758 0.490937 0.191843 0.137462 0.682779 0.317221 0.758071 72176.71 -0.312405 0.28593 0.526475 0.231467 0.092284 0.537065 0.462935 0.284418 0.142209 0.142209 5.550941 9.198185 NMV_0689 2191651 CDS -2 671878 672303 426 validated/Curated no proQ RNA-binding protein ProQ 1a : Function from experimental evidences in the studied strain f : factor 2 : Cytoplasmic 2020-07-05 18:38:47 no 32499480 RNA-binding protein with regulatory function, which binds to highly structured regions and generally acts to stabilize its RNA targets. Loss of ProQ alters transcript levels of >250 genes. 2 vladimir 0.2723 0.3028 0.237089 0.187793 0.539906 0.460094 0.211268 0.246479 0.373239 0.169014 0.619718 0.380282 0.359155 0.295775 0.112676 0.232394 0.408451 0.591549 0.246479 0.366197 0.225352 0.161972 0.591549 0.408451 0.790054 15527.06 -0.423404 0.312057 0.475177 0.177305 0.085106 0.524823 0.475177 0.262411 0.148936 0.113475 8.74044 9.475177 NMV_0690 2191652 CDS -2 672394 673494 1101 validated/Curated no aroC chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 4.2.3.5 CHORISMATE-SYNTHASE-RXN PWY-6163 2018-01-30 13:36:16 no Catalyses the last of the seven steps in the shikimate pathway, which is used for the biosynthesis of aromatic amino acids: 5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate. 2 vladimir 0.241599 0.3479 0.252498 0.158038 0.600363 0.399637 0.258856 0.217984 0.40327 0.119891 0.621253 0.378747 0.291553 0.239782 0.226158 0.242507 0.46594 0.53406 0.174387 0.585831 0.128065 0.111717 0.713896 0.286104 0.728855 39209.425 -0.309563 0.355191 0.554645 0.196721 0.095628 0.543716 0.456284 0.262295 0.142077 0.120219 6.243935 9.571038 NMV_0691 2191653 CDS +2 673637 674725 1089 validated/Curated no trmA tRNA/tmRNA (uracil-C(5))-methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.-, 2.1.1.35 TRNA-URACIL-5--METHYLTRANSFERASE-RXN 2018-01-18 16:39:10 no Dual-specificity methyltransferase that catalyses the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). 1 vladimir 0.264463 0.2332 0.258035 0.244261 0.491276 0.508724 0.256198 0.198347 0.349862 0.195592 0.548209 0.451791 0.338843 0.209366 0.173554 0.278237 0.38292 0.61708 0.198347 0.292011 0.250689 0.258953 0.5427 0.4573 0.651043 41161.315 -0.328729 0.279006 0.439227 0.20442 0.118785 0.527624 0.472376 0.281768 0.138122 0.143646 5.462502 9.61326 NMV_0692 2191654 CDS +1 674746 675939 1194 validated/Curated no tyrB aromatic-amino-acid aminotransferase (AROAT; ARAT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.13 : Phenylalanine ; 1.5.1.14 : Tyrosine ; 2.6.1.57 BRANCHED-CHAINAMINOTRANSFERLEU-RXN$PHEAMINOTRANS-RXN$TYRAMINOTRANS-RXN LEUSYN-PWY$PHESYN$TYRSYN 2018-01-30 10:42:14 no Catalyses the following reaction: aromatic amino acid + 2-oxoglutarate <=> aromatic oxo acid + L-glutamate. 2 vladimir 0.226968 0.2948 0.263819 0.214405 0.558626 0.441374 0.218593 0.21608 0.366834 0.198492 0.582915 0.417085 0.30402 0.208543 0.188442 0.298995 0.396985 0.603015 0.158291 0.459799 0.236181 0.145729 0.69598 0.30402 0.725417 44725.41 -0.178086 0.261965 0.501259 0.214106 0.138539 0.596977 0.403023 0.246851 0.123426 0.123426 5.594414 9.97733 NMV_tRNA_54 2194869 tRNA -1 676004 676079 76 validated/Curated no Arg tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:51:10 no tRNA Arg anticodon CCG. vladimir NMV_0694 2191656 CDS +2 676364 677203 840 validated/Curated no putative cytochrome c 3 : Putative function from multiple computational evidences c : carrier 6 : Inner membrane-associated 2018-01-18 16:40:31 no Belongs to the class IE of cytochrome c. 2 vladimir 0.258333 0.2774 0.27619 0.188095 0.553571 0.446429 0.257143 0.185714 0.442857 0.114286 0.628571 0.371429 0.310714 0.289286 0.182143 0.217857 0.471429 0.528571 0.207143 0.357143 0.203571 0.232143 0.560714 0.439286 0.751752 28754.08 -0.24767 0.387097 0.605735 0.157706 0.078853 0.591398 0.408602 0.229391 0.11828 0.111111 5.885368 9.139785 NMV_0696 2191658 CDS -1 677669 680521 2853 validated/Curated no gcvP glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein; glycine decarboxylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.5 : Glycine cleavage ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 1.4.4.2 GCVMULTI-RXN$GCVP-RXN$GCVT-RXN$RXN-8629 1CMET2-PWY$GLYCINE-SYN2-PWY$GLYCLEAV-PWY$PWY-2201 2020-04-21 15:08:17 no Is part of the glycine cleavage multienzyme complex (GCV), which catalyses the catabolism of glycine. 2 vladimir 0.228882 0.3000 0.267788 0.203295 0.567823 0.432177 0.235542 0.206099 0.39327 0.165089 0.599369 0.400631 0.309148 0.250263 0.161935 0.278654 0.412198 0.587802 0.141956 0.443743 0.24816 0.166141 0.691903 0.308097 0.787268 104108.265 -0.165368 0.306316 0.523158 0.204211 0.113684 0.576842 0.423158 0.253684 0.126316 0.127368 5.466454 9.695789 NMV_0697 2191659 CDS -1 680552 680911 360 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-02-15 13:20:38 no 1 vladimir 0.166667 0.2722 0.255556 0.305556 0.527778 0.472222 0.183333 0.316667 0.258333 0.241667 0.575 0.425 0.166667 0.266667 0.166667 0.4 0.433333 0.566667 0.15 0.233333 0.341667 0.275 0.575 0.425 0.600639 13188.5 0.789076 0.252101 0.504202 0.327731 0.10084 0.747899 0.252101 0.12605 0.067227 0.058824 6.765709 9.436975 NMV_0698 2191660 CDS -2 681082 681705 624 validated/Curated no putative lipolytic enzyme 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-18 16:42:02 no Belongs to a family of lipolytic enzymes, named G-D-S-L, with serine as part of their active site. 2 vladimir 0.250779 0.2944 0.260125 0.194704 0.554517 0.445483 0.257009 0.228972 0.350467 0.163551 0.579439 0.420561 0.294393 0.233645 0.191589 0.280374 0.425234 0.574766 0.200935 0.420561 0.238318 0.140187 0.658879 0.341121 0.627294 22967.39 -0.176056 0.309859 0.502347 0.234742 0.093897 0.586854 0.413146 0.230047 0.13615 0.093897 9.187233 8.953052 NMV_0699 2191661 CDS -1 681713 682264 552 validated/Curated no tag DNA-3-methyladenine glycosylase I (3-methyladenine-DNA glycosylase I, constitutive; TAG I; DNA-3-methyladenine glycosidase I) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.2.2.20 RXN0-5189 2018-01-18 16:42:59 no Catalyses the hydrolysis of alkylated DNA, releasing 3-methyladenine. 2 vladimir 0.282609 0.2736 0.240942 0.202899 0.514493 0.485507 0.25 0.233696 0.336957 0.179348 0.570652 0.429348 0.402174 0.179348 0.152174 0.266304 0.331522 0.668478 0.195652 0.407609 0.233696 0.163043 0.641304 0.358696 0.687332 21215.09 -0.519126 0.229508 0.437158 0.185792 0.169399 0.519126 0.480874 0.300546 0.153005 0.147541 5.635323 9.502732 NMV_0700 2191662 CDS -1 682268 682786 519 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-02-15 13:21:27 no 2 vladimir 0.248555 0.3372 0.246628 0.16763 0.583815 0.416185 0.254335 0.248555 0.364162 0.132948 0.612717 0.387283 0.294798 0.271676 0.190751 0.242775 0.462428 0.537572 0.196532 0.491329 0.184971 0.127168 0.676301 0.323699 0.671738 18852.495 -0.258721 0.348837 0.540698 0.186047 0.104651 0.55814 0.44186 0.197674 0.093023 0.104651 5.134377 9.94186 NMV_0701 2191663 CDS -2 682786 684447 1662 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-18 16:43:34 no Homologous to E. coli paraquat-inducible protein B and to Mce (mammalian cell entry) proteins of M. tuberculosis. 2 vladimir 0.268953 0.2906 0.238267 0.202166 0.528881 0.471119 0.314079 0.229242 0.312274 0.144404 0.541516 0.458484 0.3213 0.220217 0.17148 0.287004 0.391697 0.608303 0.17148 0.422383 0.231047 0.17509 0.65343 0.34657 0.68782 60427.88 -0.305244 0.282098 0.553345 0.249548 0.074141 0.500904 0.499096 0.22604 0.117541 0.108499 6.462898 8.444846 NMV_0702 2191664 CDS -1 684440 685744 1305 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-18 16:44:12 no Homologous to paraquat-inducible protein A of E. coli. 1 vladimir 0.167816 0.2582 0.297318 0.276628 0.555556 0.444444 0.22069 0.22069 0.328736 0.229885 0.549425 0.450575 0.195402 0.273563 0.174713 0.356322 0.448276 0.551724 0.087356 0.28046 0.388506 0.243678 0.668966 0.331034 0.622898 47958.845 0.530184 0.320276 0.511521 0.25576 0.131336 0.675115 0.324885 0.175115 0.103687 0.071429 8.6912 9.541475 NMV_0703 2191665 CDS +2 686249 686878 630 validated/Curated no hemO heme oxygenase HemO 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.14.14.18 HEME-OXYGENASE-DECYCLIZING-RXN 2018-01-19 10:24:48 no 10629191 Is the enzyme that carries out the oxidation of heme. It cleaves the heme ring at the alpha-methene bridge to form biliverdin and carbon monoxide. 2 vladimir 0.277778 0.2873 0.242857 0.192063 0.530159 0.469841 0.219048 0.214286 0.4 0.166667 0.614286 0.385714 0.395238 0.233333 0.12381 0.247619 0.357143 0.642857 0.219048 0.414286 0.204762 0.161905 0.619048 0.380952 0.728937 23520.6 -0.476077 0.267943 0.464115 0.172249 0.157895 0.54067 0.45933 0.320574 0.167464 0.15311 5.720345 9.732057 NMV_0704 2191666 CDS +2 687053 689431 2379 validated/Curated no hpuB hmbR hemoglobin-haptoglobin utilization protein B 1b : Function from experimental evidences in the studied species rc : receptor 8 : Outer membrane-associated 2018-01-18 16:45:28 no 9157245 Belongs to the TonB-dependent receptor family. Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex and is required for heme uptake. 1 vladimir 0.261034 0.2657 0.256831 0.216478 0.522488 0.477512 0.27995 0.215637 0.31652 0.187894 0.532156 0.467844 0.350567 0.201765 0.223203 0.224464 0.424968 0.575032 0.152585 0.379571 0.230769 0.237074 0.61034 0.38966 0.713885 89388.255 -0.698106 0.29798 0.52904 0.175505 0.127525 0.491162 0.508838 0.253788 0.14899 0.104798 9.376396 9.710859 NMV_0705 2191667 CDS -2 689764 690771 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:45:41 no Belongs to the IS5 family. 2 vladimir 0.284722 0.2996 0.225198 0.190476 0.524802 0.475198 0.285714 0.285714 0.267857 0.160714 0.553571 0.446429 0.372024 0.205357 0.178571 0.244048 0.383929 0.616071 0.196429 0.407738 0.229167 0.166667 0.636905 0.363095 0.66346 38428.57 -0.58806 0.271642 0.423881 0.2 0.119403 0.480597 0.519403 0.295522 0.18806 0.107463 9.423927 9.223881 NMV_0706 2191668 CDS +1 691027 691272 246 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 12:49:26 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_0707) encodes the cognate toxin. 3 vladimir 0.349593 0.1626 0.239837 0.247967 0.402439 0.597561 0.353659 0.170732 0.341463 0.134146 0.512195 0.487805 0.341463 0.231707 0.158537 0.268293 0.390244 0.609756 0.353659 0.085366 0.219512 0.341463 0.304878 0.695122 0.523727 8862.78 -0.290123 0.308642 0.45679 0.209877 0.061728 0.506173 0.493827 0.271605 0.148148 0.123457 6.934044 9.17284 NMV_0707 2191669 CDS +3 691269 691655 387 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 12:49:35 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_0706) encodes the cognate antitoxin. 1 vladimir 0.30491 0.1705 0.25323 0.271318 0.423773 0.576227 0.302326 0.20155 0.317829 0.178295 0.51938 0.48062 0.333333 0.178295 0.147287 0.341085 0.325581 0.674419 0.27907 0.131783 0.294574 0.294574 0.426357 0.573643 0.545871 14651.395 -0.092187 0.210938 0.398438 0.265625 0.117188 0.554688 0.445312 0.28125 0.132812 0.148438 5.157127 8.546875 NMV_0709 2191671 CDS -2 692260 692736 477 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-02-15 13:24:45 no 2 vladimir 0.245283 0.3145 0.287212 0.15304 0.601677 0.398323 0.245283 0.194969 0.421384 0.138365 0.616352 0.383648 0.27044 0.257862 0.264151 0.207547 0.522013 0.477987 0.220126 0.490566 0.176101 0.113208 0.666667 0.333333 0.647033 16175.345 -0.24557 0.43038 0.651899 0.164557 0.075949 0.56962 0.43038 0.189873 0.126582 0.063291 9.300987 9.759494 NMV_0710 2191672 CDS -1 692870 694225 1356 validated/Curated no putative peptidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.4.-.- 2018-03-23 15:23:35 no Belongs to a group of peptidases from the MEROPS peptidase family U32 (clan U-). 2 vladimir 0.285398 0.3031 0.224926 0.186578 0.528024 0.471976 0.276549 0.223451 0.345133 0.154867 0.568584 0.431416 0.369469 0.196903 0.170354 0.263274 0.367257 0.632743 0.210177 0.488938 0.159292 0.141593 0.64823 0.35177 0.788314 50869.62 -0.493792 0.259424 0.470067 0.199557 0.115299 0.523282 0.476718 0.277162 0.144124 0.133038 5.922859 9.913525 NMV_0711 2191673 CDS +2 694550 695338 789 validated/Curated no putative phosphatase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.3.- 2020-02-21 11:24:51 no 1 vladimir 0.220532 0.1914 0.353612 0.234474 0.544994 0.455006 0.228137 0.129278 0.463878 0.178707 0.593156 0.406844 0.273764 0.212928 0.186312 0.326996 0.39924 0.60076 0.159696 0.231939 0.410646 0.197719 0.642586 0.357414 0.63952 28259.295 0.100763 0.30916 0.549618 0.236641 0.083969 0.614504 0.385496 0.259542 0.10687 0.152672 4.621468 9.877863 NMV_0712 2191674 CDS -1 695384 695950 567 validated/Curated no apt adenine phosphoribosyltransferase (APRT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.4.2.7 ADENPRIBOSYLTRAN-RXN P1-PWY 2018-01-18 16:49:46 no Catalyses the following reaction: AMP + diphosphate <=> adenine + 5-phospho-alpha-D-ribose 1-diphosphate. 1 vladimir 0.234568 0.2787 0.261023 0.22575 0.539683 0.460317 0.238095 0.222222 0.402116 0.137566 0.624339 0.375661 0.280423 0.190476 0.179894 0.349206 0.37037 0.62963 0.185185 0.42328 0.201058 0.190476 0.624339 0.375661 0.663324 20421.015 0.253723 0.281915 0.473404 0.287234 0.095745 0.638298 0.361702 0.239362 0.12234 0.117021 5.821388 9.042553 NMV_0713 2191675 CDS +3 696111 696728 618 validated/Curated no gmk guanylate kinase (GMP kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.7.4.8 GMKALT-RXN$GUANYL-KIN-RXN P1-PWY$PWY-6125 2018-01-18 16:50:14 no Is essential for recycling GMP and indirectly cGMP, by catalysing the following reaction: ATP + GMP <=> ADP + GDP. 1 vladimir 0.216828 0.2330 0.305825 0.244337 0.538835 0.461165 0.199029 0.194175 0.407767 0.199029 0.601942 0.398058 0.296117 0.237864 0.169903 0.296117 0.407767 0.592233 0.15534 0.26699 0.339806 0.237864 0.606796 0.393204 0.594107 22529.51 -0.113171 0.302439 0.517073 0.243902 0.107317 0.546341 0.453659 0.268293 0.136585 0.131707 5.696098 9.619512 NMV_0714 2191676 CDS +1 696787 696993 207 validated/Curated no rpoZ DNA-directed RNA polymerase omega chain (RNAP omega subunit; transcriptase omega chain; RNA polymerase omega subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.2 : Transcription related ; 2.7.7.6 DNA-DIRECTED-RNA-POLYMERASE-RXN 2020-02-20 13:44:18 no Subunit of the RNA polymerase, which catalyses the transcription of DNA into RNA. 1 vladimir 0.280193 0.2754 0.246377 0.198068 0.521739 0.478261 0.347826 0.217391 0.333333 0.101449 0.550725 0.449275 0.304348 0.275362 0.173913 0.246377 0.449275 0.550725 0.188406 0.333333 0.231884 0.246377 0.565217 0.434783 0.614651 7499.225 -0.482353 0.323529 0.558824 0.220588 0.044118 0.455882 0.544118 0.294118 0.176471 0.117647 9.190331 10.352941 NMV_0715 2191677 CDS +3 697086 699242 2157 validated/Curated no spoT guanosine-3',5'-bis(diphosphate) 3'-pyrophophohydrolase ((ppGpp)ase; penta-phosphate guanosine-3'-pyrophosphohydrolase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.7.2 GDPPYPHOSKIN-RXN$PPGPPSYN-RXN$RXN0-6427 PPGPPMET-PWY 2018-01-18 16:51:26 no Catalyses the degradation of ppGpp, guanosine 3',5'-bis(diphosphate) + H(2)O <=> guanosine 5'-diphosphate + diphosphate, but may also act as a secondary ppGpp synthetase. 1 vladimir 0.274919 0.2448 0.24942 0.230876 0.494205 0.505795 0.289291 0.230876 0.331015 0.148818 0.561892 0.438109 0.344923 0.205841 0.154381 0.294854 0.360223 0.639777 0.190542 0.297636 0.262865 0.248957 0.560501 0.439499 0.583382 80299.235 -0.266574 0.260446 0.465181 0.239554 0.108635 0.534819 0.465181 0.274373 0.162953 0.111421 8.844902 9.21727 NMV_0716 2191678 CDS -3 699309 700493 1185 validated/Curated no coaBC coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) [includes: phosphopantothenoylcysteine decarboxylase (PPCDC; CoaC) and phosphopantothenate-cysteine ligase (phosphopantothenoylcysteine synthase; PPC synthetase; PPCS; CoaB)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.5 : Coenzyme A ; 4.1.1.36, 6.3.2.5 P-PANTOCYSDECARB-RXN$P-PANTOCYSLIG-RXN COA-PWY 2020-04-21 21:49:53 no Is a bifunctional enzyme that catalyses two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine. 1 vladimir 0.272574 0.2287 0.26076 0.237975 0.489451 0.510549 0.321519 0.179747 0.356962 0.141772 0.536709 0.463291 0.281013 0.265823 0.159494 0.293671 0.425316 0.574684 0.21519 0.240506 0.265823 0.278481 0.506329 0.493671 0.615691 42140.025 0.002792 0.327411 0.550761 0.233503 0.060914 0.573604 0.426396 0.22335 0.124365 0.098985 8.394051 9.208122 NMNmiscRNA0146 54894440 misc_RNA -1 700684 700804 121 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-28 20:47:27 28334889 Function unknown but has three paralogs. vladimir NMV_16S_4 2194879 rRNA +1 701019 702563 1545 validated/Curated no ribosomal RNA 16S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:18 vladimir NMV_tRNA_16 2194831 tRNA +1 702661 702737 77 validated/Curated no Ile tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:51:25 no tRNA Ile anticodon GAT. vladimir NMV_tRNA_17 2194832 tRNA +1 702743 702818 76 validated/Curated no Ala tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:51:35 no tRNA Ala anticodon TGC. vladimir NMV_23S_4 2194883 rRNA +1 703214 706116 2903 validated/Curated no ribosomal RNA 23S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:27 vladimir NMV_5S_4 2194887 rRNA +1 706210 706326 117 validated/Curated no ribosomal RNA 5S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:34 vladimir NMV_0721 2191683 CDS +3 706527 706826 300 validated/Curated no comE3 DNA-binding competence protein ComE3 1c : Function from experimental evidences in the studied genus f : factor 11 : Membrane 2018-01-18 16:52:48 no 11325945 ComE is a DNA-binding protein involved in neisserial competence. The comE gene is present in four copies in the genome, located downstream of each of the rRNA operons. 1 vladimir 0.230108 0.2430 0.305376 0.221505 0.548387 0.451613 0.264516 0.206452 0.341935 0.187097 0.548387 0.451613 0.245161 0.277419 0.174194 0.303226 0.451613 0.548387 0.180645 0.245161 0.4 0.174194 0.645161 0.354839 0.54012 16527.075 0.105844 0.331169 0.512987 0.214286 0.084416 0.642857 0.357143 0.227273 0.175325 0.051948 10.242104 8.857143 NMV_0722 2191684 CDS -1 706928 707338 411 validated/Curated partial truncated hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-06-12 13:14:42 no 1 vladimir 0.242972 0.2631 0.277108 0.216867 0.540161 0.459839 0.301205 0.13253 0.39759 0.168675 0.53012 0.46988 0.289157 0.289157 0.186747 0.23494 0.475904 0.524096 0.138554 0.36747 0.246988 0.246988 0.614458 0.385542 0.628011 17542.96 -0.250909 0.387879 0.6 0.145455 0.133333 0.557576 0.442424 0.236364 0.127273 0.109091 6.22065 9.321212 NMV_0723 2191685 CDS -2 707488 708081 594 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 18:23:34 no 1 vladimir 0.287879 0.1936 0.281145 0.237374 0.474747 0.525253 0.272727 0.146465 0.39899 0.181818 0.545455 0.454545 0.383838 0.176768 0.186869 0.252525 0.363636 0.636364 0.207071 0.257576 0.257576 0.277778 0.515152 0.484848 0.561608 21790.77 -0.46599 0.284264 0.507614 0.208122 0.121827 0.532995 0.467005 0.309645 0.177665 0.13198 7.931023 9.446701 NMV_0724 2191686 CDS +1 708214 709125 912 validated/Curated no prmB 50S ribosomal protein L3 glutamine methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1.298 RXN0-1241 2018-01-18 16:56:30 no Catalyses the following reaction: S-adenosyl-L-methionine + [ribosomal protein L3]-L-glutamine <=> S-adenosyl-L-homocysteine + [ribosomal protein L3]-N(5)-methyl-L-glutamine. 1 vladimir 0.232456 0.1776 0.283991 0.305921 0.461623 0.538377 0.184211 0.197368 0.407895 0.210526 0.605263 0.394737 0.332237 0.190789 0.148026 0.328947 0.338816 0.661184 0.180921 0.144737 0.296053 0.378289 0.440789 0.559211 0.598893 33953.17 0.027393 0.240924 0.452145 0.273927 0.132013 0.59736 0.40264 0.273927 0.09571 0.178218 4.358711 9.693069 NMV_0726 2191688 CDS +2 709406 710143 738 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-08 18:23:06 no 1 vladimir 0.296748 0.1667 0.257453 0.279133 0.424119 0.575881 0.308943 0.142276 0.300813 0.247967 0.443089 0.556911 0.390244 0.195122 0.174797 0.239837 0.369919 0.630081 0.191057 0.162602 0.296748 0.349593 0.45935 0.54065 0.618524 28048.67 -0.6 0.273469 0.461224 0.17551 0.155102 0.522449 0.477551 0.244898 0.146939 0.097959 9.295647 9.065306 NMV_0727 2191689 CDS +1 710269 710541 273 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-18 16:57:17 no Contains an amino acid-binding ACT, found in a variety of contexts and proposed to be a conserved regulatory binding fold. 1 vladimir 0.296703 0.2198 0.21978 0.263736 0.43956 0.56044 0.362637 0.175824 0.296703 0.164835 0.472527 0.527473 0.351648 0.131868 0.120879 0.395604 0.252747 0.747253 0.175824 0.351648 0.241758 0.230769 0.593407 0.406593 0.705134 10367.665 0.031111 0.177778 0.422222 0.311111 0.066667 0.5 0.5 0.277778 0.133333 0.144444 5.282845 9 NMV_0728 2191690 CDS +3 710556 711911 1356 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:24:24 no 2 vladimir 0.233776 0.2692 0.286136 0.210914 0.55531 0.44469 0.307522 0.123894 0.435841 0.132743 0.559735 0.440265 0.230089 0.278761 0.172566 0.318584 0.451327 0.548673 0.163717 0.404867 0.25 0.181416 0.654867 0.345133 0.733426 46317.48 0.347672 0.383592 0.611973 0.257206 0.046563 0.609756 0.390244 0.199557 0.093126 0.10643 5.08503 8.977827 NMV_0729 2191691 CDS +1 712054 712173 120 validated/Curated partial truncated IS1016 group transposase (N-terminal 18% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-08 18:22:25 no 3 vladimir 0.383333 0.1750 0.225 0.216667 0.4 0.6 0.4 0.15 0.35 0.1 0.5 0.5 0.3 0.225 0.2 0.275 0.425 0.575 0.45 0.15 0.125 0.275 0.275 0.725 0.487573 4277.81 -0.189744 0.333333 0.512821 0.230769 0.051282 0.512821 0.487179 0.230769 0.179487 0.051282 10.548973 9.487179 NMV_0730 2191692 CDS +2 712235 713242 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 16:57:49 no Belongs to the IS5 family. 2 vladimir 0.280754 0.3036 0.22619 0.189484 0.529762 0.470238 0.279762 0.294643 0.270833 0.154762 0.565476 0.434524 0.357143 0.205357 0.1875 0.25 0.392857 0.607143 0.205357 0.410714 0.220238 0.16369 0.630952 0.369048 0.662383 38387.71 -0.524179 0.265672 0.426866 0.20597 0.116418 0.501493 0.498507 0.292537 0.185075 0.107463 9.406837 9.274627 NMV_0731 2191693 CDS +1 713362 713730 369 validated/Curated partial truncated IS1016 group transposase (internal fragment corresponding to 50% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 13:15:07 no 3 vladimir 0.268817 0.1763 0.245161 0.309677 0.421505 0.578495 0.251613 0.180645 0.316129 0.251613 0.496774 0.503226 0.309677 0.180645 0.245161 0.264516 0.425806 0.574194 0.245161 0.167742 0.174194 0.412903 0.341935 0.658065 0.541611 17696.465 -0.424026 0.292208 0.487013 0.188312 0.168831 0.525974 0.474026 0.266234 0.175325 0.090909 9.614265 9.746753 NMV_0732 2191694 CDS -3 714606 715664 1059 validated/Curated no alr alanine racemase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.17 : Alanine ; 1.6.7 : Peptidoglycan (murein) ; 5.1.1.1 ALARACECAT-RXN ALADEG-PWY$ALANINE-VALINESYN-PWY 2020-02-27 10:37:56 no Catalyses the pyridoxal-dependent conversion of L-alanine into D-alanine, a key component of bacterial peptidoglycan. 1 vladimir 0.23796 0.2427 0.29084 0.228517 0.533522 0.466478 0.240793 0.175637 0.390935 0.192635 0.566572 0.433428 0.288952 0.229462 0.201133 0.280453 0.430595 0.569405 0.184136 0.322946 0.280453 0.212465 0.603399 0.396601 0.613082 38790.695 -0.134943 0.315341 0.5 0.215909 0.119318 0.588068 0.411932 0.252841 0.127841 0.125 5.631905 9.778409 NMV_0733 2191695 CDS +3 715989 716453 465 validated/Curated no putative leucine-responsive regulatory protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-18 16:59:09 no Belongs to the AsnC/Lrp subfamily of bacterial transcription regulation proteins, which bind DNA through a helix-turn-helix (HTH) motif. 1 vladimir 0.268817 0.2172 0.249462 0.264516 0.466667 0.533333 0.264516 0.245161 0.303226 0.187097 0.548387 0.451613 0.36129 0.16129 0.122581 0.354839 0.283871 0.716129 0.180645 0.245161 0.322581 0.251613 0.567742 0.432258 0.578713 17831.185 -0.214935 0.168831 0.383117 0.292208 0.097403 0.532468 0.467532 0.318182 0.168831 0.149351 6.242653 9.207792 NMNmiscRNA0154 54918981 misc_RNA -1 716532 716622 91 validated/Curated no RcoF1 RNA 1a : Function from experimental evidences in the studied strain 2018-01-29 12:28:39 28334889 Together with the neighbouring paralog RcoF2, mediates Hfq-dependent mRNA repression of prpB gene that encodes a methylisocitrate lyase. vladimir NMNmiscRNA0155 54919064 misc_RNA -1 716736 716823 88 validated/Curated no RcoF2 RNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:27:38 28334889 Together with the neighbouring paralog RcoF1, mediates Hfq-dependent mRNA repression of prpB gene that encodes a methylisocitrate lyase. vladimir NMV_0735 2191697 CDS +1 717211 717699 489 validated/Curated no dsbB disulfide bond formation protein B (disulfide oxidoreductase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein DSBBPROT-RXN 2018-01-18 16:59:36 no Is a component of the pathway that leads to disulfide bond formation in periplasmic proteins. The DsbB protein oxidizes the periplasmic protein DsbA which in turn oxidizes cysteines in other periplasmic proteins in order to make disulfide bonds. DsbB acts as a redox potential transducer across the cytoplasmic membrane. 1 vladimir 0.134969 0.2065 0.335378 0.323108 0.541922 0.458078 0.165644 0.171779 0.361963 0.300613 0.533742 0.466258 0.110429 0.294479 0.251534 0.343558 0.546012 0.453988 0.128834 0.153374 0.392638 0.325153 0.546012 0.453988 0.60382 17559.285 0.857407 0.37037 0.567901 0.265432 0.141975 0.777778 0.222222 0.098765 0.067901 0.030864 9.063438 9.407407 NMV_0736 2191698 CDS -1 717758 718486 729 validated/Curated no putative transcriptional regulatory protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2020-04-21 15:13:37 no 18641136 1 vladimir 0.264746 0.2647 0.290809 0.179698 0.555556 0.444444 0.246914 0.139918 0.477366 0.135802 0.617284 0.382716 0.358025 0.218107 0.17284 0.251029 0.390947 0.609053 0.1893 0.436214 0.222222 0.152263 0.658436 0.341564 0.835175 26014.925 -0.379339 0.31405 0.57438 0.202479 0.070248 0.541322 0.458678 0.293388 0.123967 0.169421 4.665474 9.987603 NMV_0737 2191699 CDS +1 718813 720231 1419 validated/Curated no putative amino-acid symporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-18 17:00:08 no Belongs to the sodium/alanine symporter family, the members of which transport alanine in association with sodium ions. 1 vladimir 0.178295 0.2396 0.281889 0.300211 0.521494 0.478506 0.232558 0.160677 0.38055 0.226216 0.541226 0.458774 0.200846 0.247357 0.162791 0.389006 0.410148 0.589852 0.10148 0.310782 0.302326 0.285412 0.613108 0.386892 0.68797 50401.035 0.754661 0.34322 0.516949 0.28178 0.146186 0.70339 0.29661 0.137712 0.082627 0.055085 8.630745 8.633475 NMV_0738 2191700 CDS -2 720295 720921 627 validated/Curated no putative hemolysin III (Hly-III) 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2008-05-08 18:20:52 no 2 vladimir 0.22807 0.2408 0.277512 0.253589 0.518341 0.481659 0.272727 0.200957 0.311005 0.215311 0.511962 0.488038 0.196172 0.196172 0.23445 0.373206 0.430622 0.569378 0.215311 0.325359 0.287081 0.172249 0.61244 0.38756 0.638766 22609.845 0.690385 0.350962 0.471154 0.307692 0.158654 0.697115 0.302885 0.139423 0.105769 0.033654 9.59269 8.254808 NMV_0739 2191701 CDS +2 721064 722404 1341 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 18:20:40 no 1 vladimir 0.197614 0.2349 0.343773 0.223714 0.578673 0.421327 0.203579 0.250559 0.362416 0.183445 0.612975 0.387025 0.248322 0.214765 0.214765 0.322148 0.42953 0.57047 0.14094 0.239374 0.454139 0.165548 0.693512 0.306488 0.576128 50133.115 0.020628 0.280269 0.473094 0.264574 0.09417 0.587444 0.412556 0.233184 0.121076 0.112108 7.807655 9.392377 NMV_0740 2191702 CDS +3 722478 723872 1395 validated/Curated no putative GTP-binding protein 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-18 17:01:08 no Related to HSR1 subfamily of GTP-binding proteins. 2 vladimir 0.237993 0.3297 0.267384 0.164875 0.597133 0.402867 0.232258 0.288172 0.346237 0.133333 0.634409 0.365591 0.303226 0.230108 0.208602 0.258065 0.43871 0.56129 0.178495 0.470968 0.247312 0.103226 0.71828 0.28172 0.606609 52128.835 -0.474353 0.299569 0.474138 0.200431 0.105603 0.508621 0.491379 0.282328 0.146552 0.135776 5.912926 9.657328 NMV_0741 2191703 CDS -3 724083 726971 2889 validated/Curated no infB translation initiation factor IF-2 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-18 17:01:32 no Is one of the three factors required for the initiation of protein biosynthesis in bacteria and promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. 2 vladimir 0.286258 0.2987 0.274143 0.140879 0.572863 0.427137 0.262721 0.204569 0.460021 0.07269 0.66459 0.33541 0.349948 0.265836 0.148494 0.235722 0.41433 0.58567 0.246106 0.425753 0.213915 0.114226 0.639668 0.360332 0.777339 103047.965 -0.462266 0.31185 0.537422 0.199584 0.04158 0.52079 0.47921 0.314969 0.16736 0.147609 8.254875 9.626819 NMV_0742 2191704 CDS -3 726984 728486 1503 validated/Curated no nusA transcription termination/antitermination protein NusA (N utilization substance protein A; L factor) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-18 17:01:57 no Is a transcription termination factor, which binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. 2 vladimir 0.254824 0.3127 0.259481 0.172987 0.572189 0.427811 0.229541 0.231537 0.457086 0.081836 0.688623 0.311377 0.335329 0.207585 0.161677 0.295409 0.369261 0.630739 0.199601 0.499002 0.159681 0.141717 0.658683 0.341317 0.775295 55719.705 -0.2746 0.258 0.482 0.246 0.058 0.52 0.48 0.32 0.124 0.196 4.538155 10.148 NMV_0743 2191705 CDS -3 728514 728945 432 validated/Curated no rimP ribosome maturation factor RimP 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 6.6 : Ribosome ; 2020-02-20 16:32:28 no 19150615 Facilitates maturation of 30S ribosomal subunits. 2 vladimir 0.3 0.2911 0.222222 0.186667 0.513333 0.486667 0.326667 0.18 0.353333 0.14 0.533333 0.466667 0.34 0.16 0.18 0.32 0.34 0.66 0.233333 0.533333 0.133333 0.1 0.666667 0.333333 0.793167 16605.37 -0.213423 0.261745 0.483221 0.241611 0.087248 0.52349 0.47651 0.288591 0.134228 0.154362 5.084068 9 NMV_0744 2191706 CDS +1 729310 730416 1107 validated/Curated no serC phosphoserine aminotransferase (PSAT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.11 : Serine ; 1.5.3.6 : Pyridoxine (vitamin B6) ; 2.6.1.52 PSERTRANSAM-RXN$PSERTRANSAMPYR-RXN PYRIDOXSYN-PWY$SERSYN-PWY 2020-02-24 15:54:19 no Catalyses the conversion of O-phospho-L-serine and oxoglutarate to 3-phosphonooxypyruvate and L-glutamate. 1 vladimir 0.216802 0.2349 0.300813 0.247516 0.535682 0.464318 0.230352 0.224932 0.355014 0.189702 0.579946 0.420054 0.300813 0.208672 0.186992 0.303523 0.395664 0.604336 0.119241 0.271003 0.360434 0.249322 0.631436 0.368564 0.644486 41471.715 -0.199457 0.266304 0.491848 0.214674 0.122283 0.578804 0.421196 0.236413 0.116848 0.119565 5.483864 10.217391 NMV_0745 2191707 CDS +2 730697 732331 1635 validated/Curated no eptA phosphoethanolamine transferase EptA 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 2.7.-.- 2018-03-23 15:24:57 no Catalyses the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin. 1 vladimir 0.231804 0.2685 0.251988 0.247706 0.520489 0.479511 0.266055 0.205505 0.308257 0.220183 0.513761 0.486239 0.306422 0.220183 0.154128 0.319266 0.374312 0.625688 0.122936 0.379817 0.293578 0.20367 0.673394 0.326606 0.677572 61366.235 0.012132 0.273897 0.509191 0.246324 0.141544 0.571691 0.428309 0.216912 0.123162 0.09375 7.650215 9.443015 NMV_0746 2191708 CDS +2 732407 732964 558 validated/Curated no putative NAD(P)H nitroreductase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.-.-.- R303-RXN 2018-01-18 17:08:25 no Belongs to a family of proteins involved in the reduction of nitrogen containing compounds. Members of this family utilise FMN as a cofactor and are often found to be homodimers. 1 vladimir 0.252688 0.2258 0.308244 0.213262 0.53405 0.46595 0.268817 0.209677 0.370968 0.150538 0.580645 0.419355 0.317204 0.247312 0.150538 0.284946 0.397849 0.602151 0.172043 0.22043 0.403226 0.204301 0.623656 0.376344 0.615983 20548.89 -0.28 0.27027 0.513514 0.189189 0.097297 0.567568 0.432432 0.259459 0.140541 0.118919 7.090523 9.691892 NMV_0747 2191709 fCDS -2 733165 733860 696 validated/Curated pseudo opaB opacity protein B (pseudogene part 2) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-18 17:08:48 no Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. 2 vladimir 0.304598 0.2687 0.221264 0.20546 0.489943 0.510057 0.349138 0.159483 0.301724 0.189655 0.461207 0.538793 0.362069 0.215517 0.206897 0.215517 0.422414 0.577586 0.202586 0.431034 0.155172 0.211207 0.586207 0.413793 0.63912 26137.11 -0.691342 0.311688 0.536797 0.168831 0.17316 0.467532 0.532468 0.277056 0.186147 0.090909 9.589912 9.242424 NMV_0747.1 2609492 fCDS -3 733860 733976 117 validated/Curated pseudo opaB opacity protein B (pseudogene part 1) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-18 17:08:38 Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. vladimir NMV_0748 2191710 CDS -2 736555 737310 756 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-27 18:26:35 no Has a domain found in sulfatase-modifying factor enzyme. 2 vladimir 0.256614 0.2910 0.253968 0.198413 0.544974 0.455026 0.261905 0.206349 0.325397 0.206349 0.531746 0.468254 0.325397 0.230159 0.230159 0.214286 0.460317 0.539683 0.18254 0.436508 0.206349 0.174603 0.642857 0.357143 0.696941 27893.35 -0.474104 0.342629 0.513944 0.151394 0.151394 0.561753 0.438247 0.219124 0.139442 0.079681 9.43055 9.346614 NMV_0749 2191711 fCDS -1 737435 738340 906 validated/Curated pseudo aniA pan1 copper-containing nitrite reductase (major outer-membrane protein Pan1) (pseudogene part 2) 1c : Function from experimental evidences in the studied genus e : enzyme 11 : Membrane 1.7.2.1 NITRITE-REDUCTASE-CYTOCHROME-RXN DENITRIFICATION-PWY$PWY-6523 2018-01-18 17:09:49 no 1383156, 1398981, 9413436 Is involved in nitrate assimilation in the denitrification pathway, by catalysing the following reaction: nitric oxide + H(2)O + ferricytochrome c <=> nitrite + ferrocytochrome c + 2 H(+). 2 vladimir 0.245033 0.2914 0.256071 0.207506 0.547461 0.452539 0.238411 0.15894 0.440397 0.162252 0.599338 0.400662 0.307947 0.264901 0.165563 0.261589 0.430464 0.569536 0.188742 0.450331 0.162252 0.198675 0.612583 0.387417 0.852157 31824.45 -0.133223 0.348837 0.591362 0.186047 0.119601 0.604651 0.395349 0.212625 0.10299 0.109635 5.288292 9.531561 NMV_0750 2191712 fCDS -2 738337 738594 258 validated/Curated pseudo aniA pan1 copper-containing nitrite reductase (major outer membrane protein Pan1) (pseudogene part 1) 1c : Function from experimental evidences in the studied genus e : enzyme 11 : Membrane 1.7.2.1 NITRITE-REDUCTASE-CYTOCHROME-RXN DENITRIFICATION-PWY$PWY-6523 2020-02-19 13:04:11 no 1383156, 1398981, 9413436 Is involved in nitrate assimilation in the denitrification pathway, by catalysing the following reaction: nitric oxide + H(2)O + ferricytochrome c <=> nitrite + ferrocytochrome c + 2 H(+). 2 vladimir 0.251938 0.3566 0.224806 0.166667 0.581395 0.418605 0.197674 0.197674 0.488372 0.116279 0.686047 0.313953 0.22093 0.476744 0.104651 0.197674 0.581395 0.418605 0.337209 0.395349 0.081395 0.186047 0.476744 0.523256 0.750026 8598.5 0.049412 0.435294 0.647059 0.152941 0.035294 0.635294 0.364706 0.211765 0.094118 0.117647 4.942223 9.894118 NMV_0752 2191714 fCDS +2 738968 739249 282 validated/Curated pseudo norB nitric oxide reductase subunit B (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 6 : Inner membrane-associated 1.7.2.5 NITRIC-OXIDE-REDUCTASE-RXN DENITRIFICATION-PWY 2018-01-18 17:13:18 no Catalyses the following reaction: Nitrous oxide + 2 ferricytochrome c + H(2)O <=> 2 nitric oxide + 2 ferrocytochrome c + 2 H(+). 1 vladimir 0.24159 0.2202 0.284404 0.253823 0.504587 0.495413 0.211009 0.220183 0.357798 0.211009 0.577982 0.422018 0.302752 0.229358 0.174312 0.293578 0.40367 0.59633 0.211009 0.211009 0.321101 0.256881 0.53211 0.46789 0.596568 11876.355 0.069444 0.305556 0.490741 0.231481 0.138889 0.657407 0.342593 0.185185 0.111111 0.074074 8.711388 8.814815 NMV_0753 2191715 fCDS +2 739253 741223 1971 validated/Curated pseudo norB nitric oxide reductase subunit B (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 6 : Inner membrane-associated 1.7.2.5 NITRIC-OXIDE-REDUCTASE-RXN DENITRIFICATION-PWY 2018-01-18 17:13:23 no Catalyses the following reaction: Nitrous oxide + 2 ferricytochrome c + H(2)O <=> 2 nitric oxide + 2 ferrocytochrome c + 2 H(+). 2 vladimir 0.200406 0.2750 0.256722 0.267884 0.53171 0.46829 0.21309 0.199391 0.336377 0.251142 0.535769 0.464231 0.243531 0.226788 0.171994 0.357686 0.398782 0.601218 0.144597 0.398782 0.261796 0.194825 0.660578 0.339422 0.812104 73835.785 0.35747 0.292683 0.474085 0.25 0.184451 0.655488 0.344512 0.172256 0.091463 0.080793 5.990685 9.021341 NMV_0754 2191716 CDS +3 741402 741935 534 validated/Curated no putative glutathione peroxidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.11.1.12-RXN$GLUTATHIONE-PEROXIDASE-RXN PWY-4081 2018-01-27 18:28:58 no 7890429, 8746463 Catalyses the following reaction: 2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O. 1 vladimir 0.279026 0.2191 0.264045 0.237828 0.483146 0.516854 0.264045 0.179775 0.370787 0.185393 0.550562 0.449438 0.370787 0.185393 0.151685 0.292135 0.337079 0.662921 0.202247 0.292135 0.269663 0.235955 0.561798 0.438202 0.687919 19928.05 -0.283616 0.254237 0.463277 0.20904 0.112994 0.559322 0.440678 0.276836 0.129944 0.146893 5.179131 9.497175 NMV_0755 2191717 CDS -1 741998 743182 1185 validated/Curated no putative murein tetrapeptide carboxypeptidase(LD-carboxypeptidase A) 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 3.4.17.13 3.4.17.13-RXN$RXN0-5227 2018-01-18 17:15:46 no Catalyses the cleavage of the bond N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-lysyl-|-D-alanine. 2 vladimir 0.194937 0.3190 0.254008 0.232068 0.572996 0.427004 0.225316 0.24557 0.356962 0.172152 0.602532 0.397468 0.225316 0.293671 0.194937 0.286076 0.488608 0.511392 0.134177 0.417722 0.210127 0.237975 0.627848 0.372152 0.661797 42408.825 -0.037563 0.352792 0.568528 0.200508 0.104061 0.593909 0.406091 0.200508 0.114213 0.086294 9.081917 9.467005 NMV_0756 2191718 CDS -1 743222 743626 405 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:29:01 no Contains a Histidine Triad (HIT) motif His-phi-His-phi-His-phi-phi (phi being a hydrophobic amino-acid). 1 vladimir 0.249383 0.2963 0.241975 0.212346 0.538272 0.461728 0.274074 0.281481 0.303704 0.140741 0.585185 0.414815 0.311111 0.244444 0.148148 0.296296 0.392593 0.607407 0.162963 0.362963 0.274074 0.2 0.637037 0.362963 0.712062 15234.165 -0.18209 0.238806 0.470149 0.223881 0.11194 0.567164 0.432836 0.261194 0.156716 0.104478 7.952492 9.69403 NMV_0757 2191719 CDS -2 743623 743976 354 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2008-05-08 18:17:05 no 3 vladimir 0.319209 0.2345 0.206215 0.240113 0.440678 0.559322 0.262712 0.271186 0.288136 0.177966 0.559322 0.440678 0.347458 0.237288 0.144068 0.271186 0.381356 0.618644 0.347458 0.194915 0.186441 0.271186 0.381356 0.618644 0.545993 13388.83 -0.404274 0.247863 0.42735 0.222222 0.102564 0.504274 0.495726 0.264957 0.145299 0.119658 6.761223 9.401709 NMV_0758 2191720 CDS +2 744128 744541 414 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 18:16:52 no 1 vladimir 0.280193 0.1643 0.256039 0.299517 0.42029 0.57971 0.326087 0.152174 0.297101 0.224638 0.449275 0.550725 0.297101 0.217391 0.166667 0.318841 0.384058 0.615942 0.217391 0.123188 0.304348 0.355072 0.427536 0.572464 0.626178 14809.67 0.056204 0.291971 0.525547 0.255474 0.10219 0.620438 0.379562 0.153285 0.10219 0.051095 9.577736 8.321168 NMV_0759 2191721 CDS -3 744612 745049 438 validated/Curated no rnhA ribonuclease HI (RNase HI) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.26.4 3.1.26.4-RXN 2018-01-18 17:16:53 no Is responsible for the hydrolysis of the RNA portion of RNA-DNA hybrids, and this activity requires the presence of divalent cations (Mg2+ or Mn2+) that bind its active site. 2 vladimir 0.283105 0.2945 0.280822 0.141553 0.575342 0.424658 0.280822 0.184932 0.376712 0.157534 0.561644 0.438356 0.363014 0.184932 0.253425 0.19863 0.438356 0.561644 0.205479 0.513699 0.212329 0.068493 0.726027 0.273973 0.71128 16315.65 -0.717241 0.317241 0.510345 0.158621 0.131034 0.510345 0.489655 0.296552 0.17931 0.117241 8.775047 10.110345 NMV_0760 2191722 CDS +2 745178 746032 855 validated/Curated no putative tellurite resistance protein TehB 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-18 17:18:03 no When present in high copy number, tehB is responsible for potassium tellurite resistance, probably by increasing the reduction rate of tellurite to metallic tellurium within the bacterium. 1 vladimir 0.219883 0.2117 0.339181 0.22924 0.550877 0.449123 0.182456 0.17193 0.445614 0.2 0.617544 0.382456 0.326316 0.242105 0.150877 0.280702 0.392982 0.607018 0.150877 0.221053 0.421053 0.207018 0.642105 0.357895 0.627892 31024.915 -0.088732 0.302817 0.542254 0.193662 0.119718 0.612676 0.387324 0.242958 0.09507 0.147887 4.534203 9.957746 NMV_0761 2191723 CDS -3 746082 746888 807 validated/Curated no thiD hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2.7.1.49, 2.7.4.7 OHMETPYRKIN-RXN$PYRIMSYN3-RXN 2018-01-18 17:21:41 no Catalyses the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. This protein is involved in step 2 and 3 of the subpathway that synthesises 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole. 1 vladimir 0.239157 0.2875 0.277571 0.195787 0.565056 0.434944 0.27881 0.197026 0.3829 0.141264 0.579926 0.420074 0.263941 0.27881 0.182156 0.275093 0.460967 0.539033 0.174721 0.386617 0.267658 0.171004 0.654275 0.345725 0.676271 28456.425 0.064179 0.376866 0.570896 0.231343 0.08209 0.570896 0.429104 0.223881 0.119403 0.104478 6.068336 9.298507 NMV_tRNA_53 2194868 tRNA -1 748190 748265 76 validated/Curated no Glu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:51:53 no tRNA Glu anticodon TTC. vladimir NMV_0762 2191724 fCDS -2 748402 748602 201 validated/Curated pseudo IS1655 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 17:21:54 no Belongs to the IS30 family. 2 vladimir 0.345238 0.2500 0.142857 0.261905 0.392857 0.607143 0.285714 0.357143 0.107143 0.25 0.464286 0.535714 0.321429 0.142857 0.142857 0.392857 0.285714 0.714286 0.428571 0.25 0.178571 0.142857 0.428571 0.571429 0.270345 3220.7 0.018519 0.148148 0.333333 0.333333 0.185185 0.555556 0.444444 0.222222 0.185185 0.037037 9.98629 8.481481 NMV_0763 2191725 fCDS -2 748603 749367 765 validated/Curated pseudo IS1655 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 17:22:05 no Belongs to the IS30 family. 2 vladimir 0.320261 0.3216 0.207843 0.150327 0.529412 0.470588 0.352941 0.290196 0.219608 0.137255 0.509804 0.490196 0.376471 0.184314 0.235294 0.203922 0.419608 0.580392 0.231373 0.490196 0.168627 0.109804 0.658824 0.341176 0.613733 29910.235 -0.901181 0.275591 0.397638 0.188976 0.122047 0.413386 0.586614 0.330709 0.248031 0.082677 10.222771 9.73622 NMV_0765 2191727 CDS -2 749671 751083 1413 validated/Curated no trkA Trk system potassium uptake protein TrkA (K(+)-uptake protein TrkA) 2a : Function from experimental evidences in other organisms t : transporter 1 : Unknown 4.2.A.38 : The K+ Transporter (Trk) Family ; 2018-01-18 17:22:29 no This NAD+-binding protein is a component of a low-affinity K + uptake system in E. coli. 2 vladimir 0.248408 0.3482 0.237084 0.166313 0.58528 0.41472 0.282378 0.22293 0.388535 0.106157 0.611465 0.388535 0.282378 0.203822 0.195329 0.318471 0.399151 0.600849 0.180467 0.617834 0.127389 0.07431 0.745223 0.254777 0.661755 51035.415 0.058936 0.293617 0.514894 0.285106 0.061702 0.565957 0.434043 0.253191 0.121277 0.131915 5.239479 9.489362 NMV_0766 2191728 CDS -1 751181 752704 1524 validated/Curated no fumA fumarate hydratase class I (fumarase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 4.2.1.2 FUMHYDR-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:29:37 no Catalyses the reversible hydration of fumarate to (S)-malate. Functions in the generation of fumarate for use as an anaerobic electron acceptor. 2 vladimir 0.25853 0.3077 0.259186 0.174541 0.566929 0.433071 0.281496 0.177165 0.405512 0.135827 0.582677 0.417323 0.309055 0.25 0.161417 0.279528 0.411417 0.588583 0.185039 0.496063 0.21063 0.108268 0.706693 0.293307 0.791242 54889.65 -0.142406 0.30572 0.548323 0.22288 0.072978 0.575937 0.424063 0.252465 0.114398 0.138067 4.945107 9.512821 NMV_0767 2191729 CDS -1 753011 753817 807 validated/Curated no putative amino acid-binding lipoprotein (HBP) 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-18 17:23:31 no Component of the high-affinity amino acid permease, a binding-protein-dependent transport system. 2 vladimir 0.285006 0.2689 0.246592 0.199504 0.515489 0.484511 0.29368 0.122677 0.412639 0.171004 0.535316 0.464684 0.364312 0.237918 0.126394 0.271375 0.364312 0.635688 0.197026 0.446097 0.200743 0.156134 0.64684 0.35316 0.786895 29015.535 -0.297761 0.298507 0.58209 0.190299 0.093284 0.544776 0.455224 0.264925 0.123134 0.141791 5.031624 9.05597 NMV_0768 2191730 CDS -1 753869 754120 252 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:31:08 no 1 vladimir 0.246032 0.2659 0.257937 0.230159 0.52381 0.47619 0.202381 0.214286 0.392857 0.190476 0.607143 0.392857 0.369048 0.22619 0.107143 0.297619 0.333333 0.666667 0.166667 0.357143 0.27381 0.202381 0.630952 0.369048 0.716078 9545.38 -0.250602 0.253012 0.409639 0.216867 0.13253 0.506024 0.493976 0.325301 0.120482 0.204819 4.496712 9.807229 NMV_0769 2191731 CDS +2 754220 754981 762 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:31:29 no 1 vladimir 0.275591 0.2598 0.300525 0.164042 0.560367 0.439633 0.248031 0.248031 0.393701 0.110236 0.641732 0.358268 0.385827 0.220472 0.149606 0.244094 0.370079 0.629921 0.192913 0.311024 0.358268 0.137795 0.669291 0.330709 0.646134 28649.22 -0.684585 0.245059 0.462451 0.201581 0.067194 0.474308 0.525692 0.332016 0.158103 0.173913 5.264259 10.205534 NMV_0770 2191732 CDS +2 755279 756448 1170 validated/Curated no metZ O-succinylhomoserine sulfhydrylase (OSH sulfhydrylase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.1.9 : Methionine ; 2.5.1.- RXN-9384 2018-01-22 19:52:30 no Is a pyridoxal phosphate-dependent enzyme, which is involved in step 1 of the subpathway that synthesizes L-homocysteine from O-succinyl-L-homoserine.Catalyses the following reaction: O4-succinyl-L-homoserine + H2S <=> L-homocysteine + succinate. 2 vladimir 0.233333 0.2932 0.276923 0.196581 0.570085 0.429915 0.253846 0.207692 0.366667 0.171795 0.574359 0.425641 0.279487 0.271795 0.166667 0.282051 0.438462 0.561538 0.166667 0.4 0.297436 0.135897 0.697436 0.302564 0.717054 41978.13 -0.053728 0.344473 0.526992 0.22108 0.100257 0.560411 0.439589 0.213368 0.118252 0.095116 6.642342 8.987147 NMV_0771 2191733 CDS +3 756543 756749 207 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 18:14:12 no 1 vladimir 0.188406 0.1208 0.294686 0.396135 0.415459 0.584541 0.246377 0.028986 0.347826 0.376812 0.376812 0.623188 0.202899 0.115942 0.15942 0.521739 0.275362 0.724638 0.115942 0.217391 0.376812 0.289855 0.594203 0.405797 0.765797 7532.965 1.298529 0.235294 0.382353 0.382353 0.161765 0.779412 0.220588 0.176471 0.102941 0.073529 8.944771 7.029412 NMV_0772 2191734 CDS -3 758013 758765 753 validated/Curated no rsmJ ribosomal RNA small subunit methyltransferase J 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 2.1.1.242 RXN0-6731 2017-10-25 23:35:18 no 22079366 2 vladimir 0.245684 0.3772 0.225764 0.151394 0.602922 0.397078 0.231076 0.290837 0.38247 0.095618 0.673307 0.326693 0.294821 0.2749 0.171315 0.258964 0.446215 0.553785 0.211155 0.565737 0.123506 0.099602 0.689243 0.310757 0.588861 27352.185 -0.254 0.32 0.532 0.216 0.096 0.552 0.448 0.256 0.148 0.108 8.893288 9.624 NMV_0773 2191735 CDS -2 758869 759336 468 validated/Curated no putative two-component system transcriptional regulator protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-18 17:25:04 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. Contains a Fis-type helix-turn-helix (HTH) motif. 2 vladimir 0.254274 0.3312 0.241453 0.173077 0.57265 0.42735 0.275641 0.288462 0.346154 0.089744 0.634615 0.365385 0.326923 0.192308 0.166667 0.314103 0.358974 0.641026 0.160256 0.512821 0.211538 0.115385 0.724359 0.275641 0.689391 17511.34 -0.345161 0.251613 0.464516 0.232258 0.058065 0.496774 0.503226 0.283871 0.129032 0.154839 4.919151 10.083871 NMV_0774 2191736 CDS -1 759329 760507 1179 validated/Curated no putative two-component system sensor protein 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2.7.13.3 2.7.13.3-RXN 2018-01-22 20:08:29 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. 2 vladimir 0.221374 0.3265 0.235793 0.216285 0.562341 0.437659 0.256997 0.272265 0.287532 0.183206 0.559796 0.440204 0.259542 0.223919 0.201018 0.315522 0.424936 0.575064 0.147583 0.483461 0.21883 0.150127 0.70229 0.29771 0.653069 44306.675 0.060969 0.283163 0.461735 0.244898 0.147959 0.607143 0.392857 0.211735 0.135204 0.076531 9.387825 9.329082 NMV_0775 2191737 CDS -2 760528 762825 2298 validated/Curated no parC DNA topoisomerase IV subunit A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.1.1.1 : DNA bending, supercoiling, inversion ; 5.6.2.2 5.99.1.2-RXN 2020-04-21 13:36:38 no Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. 2 vladimir 0.25718 0.2833 0.272411 0.187119 0.555701 0.444299 0.267624 0.244125 0.355091 0.133159 0.599217 0.400783 0.304178 0.23107 0.171018 0.293734 0.402089 0.597911 0.199739 0.374674 0.291123 0.134465 0.665796 0.334204 0.667219 84272.82 -0.275163 0.278431 0.47451 0.24183 0.064052 0.539869 0.460131 0.278431 0.14902 0.129412 8.235863 9.328105 NMV_0776 2191738 CDS +3 763128 763811 684 validated/Curated no gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (phosphoglyceromutase; PGAM; BPG-dependent PGAM; dPGM) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 5.4.2.11 3PGAREARR-RXN ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-31 15:01:16 no Interconverts 2-phosphoglycerate and 3-phosphoglycerate. The enzyme is transiently phosphorylated on an active site histidine by 2,3-diphosphoglyerate, which is both substrate and product. 2 vladimir 0.276316 0.2836 0.261696 0.178363 0.545322 0.454678 0.236842 0.245614 0.355263 0.162281 0.600877 0.399123 0.377193 0.179825 0.162281 0.280702 0.342105 0.657895 0.214912 0.425439 0.267544 0.092105 0.692982 0.307018 0.765056 25956.59 -0.453744 0.22467 0.436123 0.237885 0.114537 0.519824 0.480176 0.317181 0.162996 0.154185 5.919762 9.154185 NMV_0777 2191739 CDS -2 763885 764829 945 validated/Curated no putative tellurite resistance protein TehA 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.16 : The Telurite-resistance/Dicarboxylate Transporter (TDT) Family ; 2018-01-18 17:28:18 no When present in high copy number, tehA is responsible for potassium tellurite resistance, probably by increasing the reduction rate of tellurite to metallic tellurium within the bacterium. 1 vladimir 0.122751 0.2646 0.334392 0.278307 0.598942 0.401058 0.149206 0.2 0.384127 0.266667 0.584127 0.415873 0.120635 0.295238 0.222222 0.361905 0.51746 0.48254 0.098413 0.298413 0.396825 0.206349 0.695238 0.304762 0.625901 32783.405 0.933439 0.423567 0.535032 0.270701 0.143312 0.757962 0.242038 0.105096 0.073248 0.031847 9.422966 8.515924 NMV_0782 2191744 CDS +3 766110 767261 1152 validated/Curated no putative modification methylase (cytosine-specific methyltransferase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.37 2.1.1.113-RXN$2.1.1.72-RXN$DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-18 17:28:43 no Specifically methylates the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. 3 vladimir 0.313675 0.1915 0.235897 0.258974 0.42735 0.57265 0.312821 0.174359 0.335897 0.176923 0.510256 0.489744 0.353846 0.174359 0.2 0.271795 0.374359 0.625641 0.274359 0.225641 0.171795 0.328205 0.397436 0.602564 0.561159 44172.57 -0.429306 0.264781 0.442159 0.208226 0.125964 0.51928 0.48072 0.300771 0.169666 0.131105 7.372505 9.609254 NMV_0783 2191745 fCDS +2 767315 767644 330 validated/Curated pseudo conserved hypothetical protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:32:00 no 3 vladimir 0.330601 0.1885 0.237705 0.243169 0.42623 0.57377 0.311475 0.172131 0.352459 0.163934 0.52459 0.47541 0.352459 0.188525 0.155738 0.303279 0.344262 0.655738 0.327869 0.204918 0.204918 0.262295 0.409836 0.590164 0.527031 13799.47 -0.282645 0.22314 0.471074 0.22314 0.107438 0.545455 0.454545 0.297521 0.165289 0.132231 8.47747 9.735537 NMV_0784 2191746 fCDS +3 767634 768338 705 validated/Curated pseudo conserved hypothetical protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:32:10 no 1 vladimir 0.282993 0.1946 0.262585 0.259864 0.457143 0.542857 0.220408 0.179592 0.371429 0.228571 0.55102 0.44898 0.367347 0.17551 0.187755 0.269388 0.363265 0.636735 0.261224 0.228571 0.228571 0.281633 0.457143 0.542857 0.58503 28491.235 -0.458197 0.229508 0.418033 0.22541 0.147541 0.532787 0.467213 0.340164 0.159836 0.180328 5.139397 9.70082 NMV_0785 2191747 CDS -2 768427 771084 2658 validated/Curated no alaS alanine-tRNA ligase (alanyl-tRNA synthetase; AlaRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.7 ALANINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:29:39 no Catalyses the attachment of alanine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.269333 0.3040 0.254476 0.17219 0.558476 0.441524 0.244571 0.184 0.420571 0.150857 0.604571 0.395429 0.337143 0.214857 0.182857 0.265143 0.397714 0.602286 0.226286 0.513143 0.16 0.100571 0.673143 0.326857 0.839215 95947.635 -0.350458 0.306636 0.505721 0.194508 0.101831 0.540046 0.459954 0.292906 0.144165 0.148741 5.457695 9.565217 NMV_0786 2191748 CDS +1 771256 772386 1131 validated/Curated no putative spermidine/putrescine-binding lipoprotein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 1.7.14 : Polyamine biosynthesis ; 2018-01-18 17:30:05 no This usually periplasmic spermidine/putrescine-binding protein is involved in the polyamine transport system. It is required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. 1 vladimir 0.282051 0.2414 0.270557 0.206012 0.511936 0.488064 0.323607 0.159151 0.352785 0.164456 0.511936 0.488064 0.374005 0.228117 0.137931 0.259947 0.366048 0.633952 0.148541 0.33687 0.320955 0.193634 0.657825 0.342175 0.67387 41895.875 -0.467553 0.260638 0.531915 0.194149 0.103723 0.531915 0.468085 0.273936 0.135638 0.138298 5.624428 9.327128 NMV_0787 2191749 CDS -1 772427 773290 864 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 18:11:39 no 2 vladimir 0.162037 0.2812 0.28588 0.270833 0.56713 0.43287 0.215278 0.215278 0.319444 0.25 0.534722 0.465278 0.149306 0.28125 0.184028 0.385417 0.465278 0.534722 0.121528 0.347222 0.354167 0.177083 0.701389 0.298611 0.632877 31212.72 0.749129 0.372822 0.501742 0.28223 0.135889 0.665505 0.334495 0.12892 0.090592 0.038328 9.914619 8.473868 NMV_0788 2191750 CDS +1 773476 773964 489 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-30 19:08:01 no 2 vladimir 0.278119 0.2495 0.241309 0.231084 0.490798 0.509202 0.337423 0.214724 0.276074 0.171779 0.490798 0.509202 0.331288 0.226994 0.153374 0.288344 0.380368 0.619632 0.165644 0.306748 0.294479 0.233129 0.601227 0.398773 0.644579 18382.595 -0.32284 0.253086 0.481481 0.222222 0.092593 0.537037 0.462963 0.216049 0.141975 0.074074 9.830559 9.481481 NMV_0789 2191751 CDS -1 774026 774931 906 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-18 17:30:46 no Belongs to the AraC-family of transcriptional regulators. 1 vladimir 0.246137 0.2439 0.283664 0.226269 0.527594 0.472406 0.218543 0.264901 0.331126 0.18543 0.596026 0.403974 0.31457 0.172185 0.198675 0.31457 0.370861 0.629139 0.205298 0.294702 0.321192 0.178808 0.615894 0.384106 0.623013 33437.1 -0.201993 0.272425 0.488372 0.245847 0.109635 0.538206 0.461794 0.255814 0.156146 0.099668 8.898201 8.963455 NMV_0791 2191753 CDS +1 775060 775395 336 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 18:11:00 no 1 vladimir 0.252976 0.2946 0.270833 0.181548 0.565476 0.434524 0.258929 0.142857 0.473214 0.125 0.616071 0.383929 0.285714 0.366071 0.133929 0.214286 0.5 0.5 0.214286 0.375 0.205357 0.205357 0.580357 0.419643 0.793481 11502.77 0.181982 0.459459 0.540541 0.18018 0.081081 0.612613 0.387387 0.243243 0.135135 0.108108 7.016716 9.27027 NMV_0792 2191754 CDS +3 775677 776099 423 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 18:10:48 no 1 vladimir 0.245863 0.2411 0.255319 0.257683 0.496454 0.503546 0.255319 0.184397 0.340426 0.219858 0.524823 0.475177 0.262411 0.184397 0.22695 0.326241 0.411348 0.588652 0.219858 0.35461 0.198582 0.22695 0.553191 0.446809 0.607715 15603.485 0.087143 0.3 0.478571 0.264286 0.114286 0.585714 0.414286 0.235714 0.135714 0.1 8.841911 9.442857 NMV_0794 2191756 CDS +3 776205 776768 564 validated/Curated no pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (phosphatidylglycerophosphate synthase; PGP synthase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.1 : Phospholipid ; 2.7.8.5 PHOSPHAGLYPSYN-RXN PWY-5269$PWY-5668$PWY4FS-7$PWY4FS-8 2018-01-18 17:39:21 no Catalyses the following reaction in the committed step to the synthesis of acidic phospholipids: CDP-diacylglycerol + sn-glycerol 3-phosphate <=> CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. 1 vladimir 0.205674 0.2553 0.234043 0.304965 0.489362 0.510638 0.287234 0.180851 0.297872 0.234043 0.478723 0.521277 0.180851 0.239362 0.12234 0.457447 0.361702 0.638298 0.148936 0.345745 0.281915 0.223404 0.62766 0.37234 0.601638 21328.95 0.937433 0.245989 0.433155 0.320856 0.15508 0.721925 0.278075 0.139037 0.074866 0.064171 8.938362 8.55615 NMV_tRNA_18 2194833 tRNA +1 776848 776923 76 validated/Curated no Gly tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:52:11 no tRNA Gly anticodon GCC. vladimir NMV_tRNA_19 2194834 tRNA +1 776949 777024 76 validated/Curated no Gly tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:52:23 no tRNA Gly anticodon GCC. vladimir NMV_tRNA_20 2194835 tRNA +1 777048 777123 76 validated/Curated no Gly tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:52:32 no tRNA Gly anticodon GCC. vladimir NMV_tRNA_21 2194836 tRNA +1 777145 777220 76 validated/Curated no Gly tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:52:46 no tRNA Gly anticodon GCC. vladimir NMV_tRNA_22 2194837 tRNA +1 777247 777320 74 validated/Curated no Cys tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:52:56 no tRNA Cys anticodon GCA. vladimir NMV_tRNA_23 2194838 tRNA +1 777421 777510 90 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:53:05 no tRNA Leu anticodon TAA. vladimir NMV_0795 2191757 CDS +2 777566 778666 1101 validated/Curated no putative protease SohB 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.4.21.- 3.4.21.83-RXN$3.4.21.87-RXN$3.4.21.92-RXN$3.4.24.55-RXN 2018-01-18 17:40:32 no Belongs to the MEROPS peptidase family S49 (protease IV family, clan S-). 1 vladimir 0.271605 0.1757 0.302944 0.249763 0.478632 0.521368 0.253561 0.182336 0.393162 0.17094 0.575499 0.424501 0.367521 0.173789 0.14245 0.316239 0.316239 0.683761 0.193732 0.17094 0.373219 0.262108 0.54416 0.45584 0.618052 39370.735 -0.250857 0.245714 0.42 0.251429 0.094286 0.511429 0.488571 0.32 0.165714 0.154286 6.14695 8.92 NMV_0796 2191758 CDS -2 778717 779583 867 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-18 17:40:53 no Belongs to the family of ABC-type multidrug transport systems. 1 vladimir 0.191465 0.2399 0.305652 0.262976 0.545559 0.454441 0.214533 0.231834 0.33218 0.221453 0.564014 0.435986 0.214533 0.190311 0.207612 0.387543 0.397924 0.602076 0.145329 0.297578 0.377163 0.179931 0.67474 0.32526 0.567906 32699.315 0.44375 0.270833 0.444444 0.295139 0.145833 0.645833 0.354167 0.197917 0.128472 0.069444 9.735817 9.527778 NMV_0798 2191760 fCDS -2 779848 780297 450 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 17:41:05 no Belongs to the IS5 family. 2 vladimir 0.274123 0.2675 0.252193 0.20614 0.519737 0.480263 0.256579 0.269737 0.296053 0.177632 0.565789 0.434211 0.381579 0.210526 0.177632 0.230263 0.388158 0.611842 0.184211 0.322368 0.282895 0.210526 0.605263 0.394737 0.635602 17262.1 -0.615232 0.284768 0.423841 0.198675 0.139073 0.490066 0.509934 0.317881 0.218543 0.099338 9.635521 9.668874 NMV_0799 2191761 fCDS -3 780300 780842 543 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-18 17:41:25 no Belongs to the IS5 family. 2 vladimir 0.282636 0.3105 0.219265 0.187579 0.529785 0.470215 0.330798 0.269962 0.235741 0.163498 0.505703 0.494297 0.288973 0.243346 0.205323 0.262357 0.448669 0.551331 0.228137 0.418251 0.21673 0.136882 0.634981 0.365019 0.602687 30052.735 -0.429008 0.278626 0.473282 0.206107 0.087786 0.5 0.5 0.259542 0.164122 0.09542 9.656349 9.51145 NMV_0800 2191762 CDS -2 781723 782592 870 validated/Curated no putative 2-hydroxy-3-oxopropionate reductase (tartronate semialdehyde reductase; TSAR) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.1.60 RXN0-5289$TSA-REDUCT-RXN GALACTARDEG-PWY$GLUCARDEG-PWY 2018-01-19 10:41:18 no Catalyses the following reaction: (R)-glycerate + NAD(P)(+) <=> 2-hydroxy-3-oxopropanoate + NAD(P)H. 2 vladimir 0.23908 0.3253 0.254023 0.181609 0.57931 0.42069 0.244828 0.182759 0.417241 0.155172 0.6 0.4 0.268966 0.258621 0.165517 0.306897 0.424138 0.575862 0.203448 0.534483 0.17931 0.082759 0.713793 0.286207 0.693128 30406.6 0.153979 0.349481 0.560554 0.238754 0.086505 0.622837 0.377163 0.193772 0.093426 0.100346 5.336037 9.013841 NMV_0801 2191763 CDS -1 782687 783604 918 validated/Curated no hisB imidazoleglycerol-phosphate dehydratase (IGPD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 4.2.1.19 IMIDPHOSDEHYD-RXN HISTSYN-PWY 2018-01-19 10:42:07 no Catalyses the following reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. 2 vladimir 0.279956 0.3497 0.217865 0.152505 0.567538 0.432462 0.294118 0.27451 0.336601 0.094771 0.611111 0.388889 0.316993 0.22549 0.199346 0.25817 0.424837 0.575163 0.228758 0.54902 0.117647 0.104575 0.666667 0.333333 0.680107 33738.11 -0.427541 0.318033 0.488525 0.203279 0.098361 0.495082 0.504918 0.301639 0.180328 0.121311 8.623482 9.47541 NMV_0802 2191764 CDS -2 783601 784698 1098 validated/Curated no hisC histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 2.6.1.9 HISTAMINOTRANS-RXN HISTSYN-PWY 2018-01-19 10:42:31 no Catalyses the following reaction: L-histidinol phosphate + 2-oxoglutarate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. 2 vladimir 0.234973 0.3315 0.229508 0.204007 0.56102 0.43898 0.254098 0.262295 0.330601 0.153005 0.592896 0.407104 0.273224 0.248634 0.163934 0.314208 0.412568 0.587432 0.177596 0.483607 0.193989 0.144809 0.677596 0.322404 0.662172 39939.59 0.087397 0.287671 0.509589 0.243836 0.10411 0.613699 0.386301 0.208219 0.109589 0.09863 6.005531 9.361644 NMV_0803 2191765 CDS -2 784744 786033 1290 validated/Curated no hisD histidinol dehydrogenase (HDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 1.1.1.23 HISTALDEHYD-RXN$HISTOLDEHYD-RXN HISTSYN-PWY 2018-01-19 10:42:53 no Catalyses the following reaction: L-histidinol + 2 NAD(+) <=> L-histidine + 2 NADH. 2 vladimir 0.253488 0.3209 0.25969 0.165891 0.58062 0.41938 0.25814 0.206977 0.409302 0.125581 0.616279 0.383721 0.302326 0.274419 0.15814 0.265116 0.432558 0.567442 0.2 0.481395 0.211628 0.106977 0.693023 0.306977 0.716828 46335.77 -0.142191 0.333333 0.536131 0.20979 0.081585 0.564103 0.435897 0.242424 0.114219 0.128205 5.132454 9.589744 NMV_0804 2191766 CDS -3 786030 786929 900 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:32:35 no 3 vladimir 0.323333 0.2278 0.21 0.238889 0.437778 0.562222 0.316667 0.183333 0.33 0.17 0.513333 0.486667 0.376667 0.183333 0.17 0.27 0.353333 0.646667 0.276667 0.316667 0.13 0.276667 0.446667 0.553333 0.623102 33631.15 -0.503344 0.267559 0.458194 0.227425 0.09699 0.481605 0.518395 0.32107 0.183946 0.137124 9.087257 8.80602 NMV_0805 2191767 CDS -2 787033 787686 654 validated/Curated no hisG ATP phosphoribosyltransferase (ATP-PRTase; ATP-PRT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 2.4.2.17 ATPPHOSPHORIBOSYLTRANS-RXN HISTSYN-PWY 2018-01-19 10:43:50 no Catalyses the following reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate <=> ATP + 5-phospho-alpha-D-ribose 1-diphosphate. 1 vladimir 0.221713 0.2523 0.299694 0.2263 0.551988 0.448012 0.266055 0.188073 0.40367 0.142202 0.591743 0.408257 0.284404 0.247706 0.151376 0.316514 0.399083 0.600917 0.114679 0.321101 0.344037 0.220183 0.665138 0.334862 0.63967 23262.2 0.178802 0.313364 0.511521 0.276498 0.078341 0.612903 0.387097 0.253456 0.142857 0.110599 8.468712 9.059908 NMV_0806 2191768 CDS -2 787765 788418 654 validated/Curated no putative SCO1-like lipoprotein 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2018-01-19 10:44:12 no Belongs to the SCO1/SenC family of proteins involved in biogenesis of respiratory and photosynthetic systems. 1 vladimir 0.233945 0.2737 0.276758 0.215596 0.550459 0.449541 0.256881 0.188073 0.380734 0.174312 0.568807 0.431193 0.307339 0.270642 0.16055 0.261468 0.431193 0.568807 0.137615 0.362385 0.288991 0.211009 0.651376 0.348624 0.658985 23154.14 -0.197696 0.341014 0.589862 0.202765 0.087558 0.543779 0.456221 0.230415 0.105991 0.124424 4.969887 8.672811 NMV_tRNA_24 2194839 tRNA +1 788694 788778 85 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:53:24 no tRNA Leu anticodon CAA. vladimir NMV_0808 2191770 CDS +1 789034 790041 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 10:44:25 no Belongs to the IS5 family. 2 vladimir 0.281746 0.3056 0.222222 0.190476 0.527778 0.472222 0.279762 0.294643 0.270833 0.154762 0.565476 0.434524 0.357143 0.205357 0.1875 0.25 0.392857 0.607143 0.208333 0.416667 0.208333 0.166667 0.625 0.375 0.661226 38387.71 -0.524179 0.265672 0.426866 0.20597 0.116418 0.501493 0.498507 0.292537 0.185075 0.107463 9.406837 9.274627 NMV_0809 2191771 CDS +1 790276 791367 1092 validated/Curated no putative prophage integrase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 10:44:53 no Is necessary for the integration of a phage into the host genome by site-specific recombination. 1 vladimir 0.292125 0.2271 0.270147 0.210623 0.497253 0.502747 0.277473 0.225275 0.337912 0.159341 0.563187 0.436813 0.32967 0.214286 0.192308 0.263736 0.406593 0.593407 0.269231 0.241758 0.28022 0.208791 0.521978 0.478022 0.48812 41276.79 -0.454545 0.267218 0.438017 0.206612 0.110193 0.523416 0.476584 0.292011 0.170799 0.121212 9.198235 9.719008 NMV_0810 2191772 CDS +2 791930 792205 276 validated/Curated no fitA antitoxin FitA 1c : Function from experimental evidences in the studied genus f : factor 2 : Cytoplasmic 2018-01-28 12:51:50 no 16156663, 16982615 Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_0811) encodes the cognate toxin. 3 vladimir 0.318841 0.2790 0.23913 0.163043 0.518116 0.481884 0.347826 0.23913 0.293478 0.119565 0.532609 0.467391 0.315217 0.282609 0.184783 0.217391 0.467391 0.532609 0.293478 0.315217 0.23913 0.152174 0.554348 0.445652 0.547878 10066.03 -0.587912 0.318681 0.516484 0.164835 0.087912 0.483516 0.516484 0.252747 0.142857 0.10989 9.056496 8.912088 NMV_0811 2191773 CDS +1 792208 792624 417 validated/Curated no fitB toxin FitB 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 2018-01-28 12:51:54 no 16156663, 16982615 Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_0810) encodes the cognate antitoxin. 2 vladimir 0.309353 0.2518 0.258993 0.179856 0.510791 0.489209 0.338129 0.18705 0.345324 0.129496 0.532374 0.467626 0.316547 0.208633 0.194245 0.280576 0.402878 0.597122 0.273381 0.359712 0.23741 0.129496 0.597122 0.402878 0.558919 15645.325 -0.385507 0.26087 0.478261 0.224638 0.07971 0.514493 0.485507 0.297101 0.152174 0.144928 5.946465 10.130435 NMV_0813 2191775 CDS +2 792854 793951 1098 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 18:05:41 no 1 vladimir 0.279599 0.2450 0.272313 0.203097 0.517304 0.482696 0.322404 0.215847 0.300546 0.161202 0.516393 0.483607 0.295082 0.199454 0.196721 0.308743 0.396175 0.603825 0.221311 0.319672 0.319672 0.139344 0.639344 0.360656 0.484008 41164.74 -0.225753 0.279452 0.430137 0.227397 0.09863 0.526027 0.473973 0.257534 0.139726 0.117808 8.074791 9.246575 NMV_0814 2191776 fCDS -3 794379 795080 702 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 10:48:35 no Belongs to the IS5 family. 2 vladimir 0.291492 0.2706 0.248257 0.189679 0.518828 0.481172 0.280335 0.246862 0.313808 0.158996 0.560669 0.439331 0.376569 0.213389 0.188285 0.221757 0.401674 0.598326 0.217573 0.351464 0.242678 0.188285 0.594142 0.405858 0.635792 26824.525 -0.571008 0.306723 0.44958 0.201681 0.105042 0.487395 0.512605 0.294118 0.184874 0.109244 9.272789 9.605042 NMV_0815 2191777 fCDS -3 795225 795539 315 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 10:48:46 no Belongs to the IS5 family. 2 vladimir 0.261006 0.3145 0.191824 0.232704 0.506289 0.493711 0.254717 0.349057 0.216981 0.179245 0.566038 0.433962 0.320755 0.160377 0.188679 0.330189 0.349057 0.650943 0.207547 0.433962 0.169811 0.188679 0.603774 0.396226 0.618008 12595.06 -0.317143 0.180952 0.371429 0.238095 0.161905 0.52381 0.47619 0.27619 0.152381 0.12381 6.451256 9.295238 NMV_0816 2191778 CDS +2 795653 796024 372 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 18:05:21 no 1 vladimir 0.322581 0.1909 0.268817 0.217742 0.459677 0.540323 0.314516 0.177419 0.346774 0.16129 0.524194 0.475806 0.33871 0.241935 0.153226 0.266129 0.395161 0.604839 0.314516 0.153226 0.306452 0.225806 0.459677 0.540323 0.526617 14158.77 -0.473984 0.235772 0.430894 0.203252 0.081301 0.504065 0.495935 0.300813 0.154472 0.146341 7.964027 9.918699 NMV_0817 2191779 CDS +2 796178 796393 216 validated/Curated no putative prophage regulator protein 3 : Putative function from multiple computational evidences r : regulator 1 : Unknown 2018-01-19 10:49:21 no Belongs to a family consisting of several short bacterial and phage proteins, which are related to the E. coli protein AlpA. AlpA suppresses two phenotypes of a lon mutant, overproduction of capsular polysaccharide and sensitivity to UV light. Several of the sequences in this family are thought to be DNA-binding proteins. 1 vladimir 0.24537 0.2454 0.287037 0.222222 0.532407 0.467593 0.222222 0.208333 0.375 0.194444 0.583333 0.416667 0.319444 0.194444 0.25 0.236111 0.444444 0.555556 0.194444 0.333333 0.236111 0.236111 0.569444 0.430556 0.732389 8078.73 -0.622535 0.28169 0.535211 0.197183 0.112676 0.492958 0.507042 0.28169 0.169014 0.112676 9.689995 9.774648 NMV_0818 2191780 CDS -1 796703 797356 654 validated/Curated no putative prophage repressor protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-03-23 15:33:20 no Similar to bacteriophage lambda C1 repressor that controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. 1 vladimir 0.278287 0.2446 0.250765 0.2263 0.495413 0.504587 0.261468 0.206422 0.330275 0.201835 0.536697 0.463303 0.302752 0.229358 0.201835 0.266055 0.431193 0.568807 0.270642 0.298165 0.220183 0.211009 0.518349 0.481651 0.59045 24693.56 -0.434562 0.276498 0.437788 0.193548 0.105991 0.534562 0.465438 0.285714 0.170507 0.115207 9.763908 9.589862 NMV_0819 2191781 CDS +1 797758 798120 363 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 18:04:37 no 2 vladimir 0.322314 0.3003 0.195592 0.181818 0.495868 0.504132 0.305785 0.247934 0.31405 0.132231 0.561983 0.438017 0.371901 0.305785 0.07438 0.247934 0.380165 0.619835 0.289256 0.347107 0.198347 0.165289 0.545455 0.454545 0.67687 13184.155 -0.289167 0.325 0.533333 0.191667 0.091667 0.466667 0.533333 0.208333 0.091667 0.116667 4.828575 9.308333 NMV_0821 2191783 CDS +3 798492 799544 1053 validated/Curated no putative prophage DNA primase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-19 10:50:29 no May act as a prophage DNA primase generating di- to penta-ribonucleotides; the predominant product being the dimer pppApG. It complexes specifically to the prophage origin of replication (ori) and its cis replication region (crr). 1 vladimir 0.248813 0.2896 0.292498 0.169041 0.582146 0.417854 0.230769 0.233618 0.378917 0.156695 0.612536 0.387464 0.296296 0.247863 0.239316 0.216524 0.487179 0.512821 0.219373 0.387464 0.259259 0.133903 0.646724 0.353276 0.570911 38196.925 -0.426571 0.34 0.517143 0.162857 0.114286 0.585714 0.414286 0.268571 0.154286 0.114286 8.401741 9.842857 NMV_0822 2191784 CDS +1 799585 801420 1836 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2015-11-21 10:57:49 no 1 vladimir 0.273038 0.2759 0.281001 0.17008 0.556883 0.443117 0.259386 0.199659 0.377133 0.163823 0.576792 0.423208 0.31058 0.249147 0.223549 0.216724 0.472696 0.527304 0.249147 0.37884 0.242321 0.129693 0.62116 0.37884 0.558451 63948.33 -0.462564 0.345299 0.511111 0.182906 0.099145 0.54359 0.45641 0.25641 0.136752 0.119658 6.925072 9.676923 NMV_0823 2191785 CDS +2 802484 804211 1728 validated/Curated no ilvI acetolactate synthase large subunit (AHAS; acetohydroxy-acid synthase large subunit; ALS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 2.2.1.6 ACETOLACTSYN-RXN$ACETOOHBUTSYN-RXN ILEUSYN-PWY$VALSYN-PWY 2018-01-19 10:51:18 no Catalyses the following reaction: 2 pyruvate <=> 2-acetolactate + CO(2). 1 vladimir 0.233218 0.2355 0.284722 0.246528 0.520255 0.479745 0.246528 0.197917 0.390625 0.164931 0.588542 0.411458 0.307292 0.21875 0.164931 0.309028 0.383681 0.616319 0.145833 0.289931 0.298611 0.265625 0.588542 0.411458 0.672914 62853.47 -0.032174 0.288696 0.525217 0.238261 0.104348 0.593043 0.406957 0.21913 0.111304 0.107826 5.781548 9.384348 NMV_0824 2191786 CDS +3 804222 804713 492 validated/Curated no ilvH acetolactate synthase small subunit (AHAS; acetohydroxy-acid synthase small subunit; ALS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 2.2.1.6 ACETOLACTSYN-RXN$ACETOOHBUTSYN-RXN ILEUSYN-PWY$VALSYN-PWY 2018-01-19 10:51:55 no Catalyses the following reaction: 2 pyruvate <=> 2-acetolactate + CO(2). 1 vladimir 0.268293 0.2439 0.254065 0.23374 0.497967 0.502033 0.304878 0.164634 0.371951 0.158537 0.536585 0.463415 0.292683 0.182927 0.182927 0.341463 0.365854 0.634146 0.207317 0.384146 0.207317 0.20122 0.591463 0.408537 0.755641 18292.35 -0.10184 0.269939 0.460123 0.294479 0.055215 0.490798 0.509202 0.312883 0.153374 0.159509 5.5252 9.392638 NMV_0825 2191787 CDS +3 804780 805073 294 validated/Curated no putative monooxygenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.-.-.- 2018-01-19 10:53:48 no 2 vladimir 0.319728 0.2449 0.227891 0.207483 0.472789 0.527211 0.285714 0.163265 0.408163 0.142857 0.571429 0.428571 0.387755 0.22449 0.091837 0.295918 0.316327 0.683673 0.285714 0.346939 0.183673 0.183673 0.530612 0.469388 0.787184 10805.78 -0.163918 0.268041 0.484536 0.226804 0.113402 0.515464 0.484536 0.268041 0.123711 0.14433 5.086739 9.28866 NMV_0826 2191788 CDS +1 805153 806166 1014 validated/Curated no ilvC ketol-acid reductoisomerase (NADP(+)) (acetohydroxy-acid isomeroreductase; alpha-keto-beta-hydroxylacil reductoisomerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 1.1.1.86 ACETOLACTREDUCTOISOM-RXN$ACETOOHBUTREDUCTOISOM-RXN ILEUSYN-PWY$VALSYN-PWY 2020-02-21 16:07:57 no Catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the branched side chain amino acids valine and isoleucine. 2 vladimir 0.269231 0.2623 0.250493 0.217949 0.512821 0.48718 0.263314 0.171598 0.431953 0.133136 0.60355 0.39645 0.343195 0.239645 0.147929 0.269231 0.387574 0.612426 0.201183 0.37574 0.171598 0.251479 0.547337 0.452663 0.860403 36436.81 -0.182493 0.320475 0.537092 0.210682 0.10089 0.5727 0.4273 0.246291 0.124629 0.121662 5.653908 9.884273 NMV_0827 2191789 CDS -1 806390 807385 996 validated/Curated no argF ornithine carbamoyltransferase (OTCase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 2.1.3.3 ORNCARBAMTRANSFER-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$CITRULLINE-DEG-PWY 2018-01-19 10:55:13 no Catalyses the following reaction: carbamoyl phosphate + L-ornithine <=> phosphate + L-citrulline. This reaction is part of the arginine biosynthetic pathway. 2 vladimir 0.272088 0.2681 0.271084 0.188755 0.539157 0.460843 0.277108 0.189759 0.391566 0.141566 0.581325 0.418675 0.325301 0.23494 0.162651 0.277108 0.39759 0.60241 0.213855 0.379518 0.259036 0.14759 0.638554 0.361446 0.702515 36686.42 -0.254381 0.299094 0.489426 0.202417 0.111782 0.549849 0.450151 0.274924 0.141994 0.132931 5.860268 9.782477 NMV_0828 2191790 CDS -1 807527 810112 2586 validated/Curated no acnB aconitate hydratase 2 (citrate hydro-lyase 2; aconitase 2) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.2.3 : Propionate degradation ; 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 4.2.1.3 4.2.1.99-RXN$ACONITATEDEHYDR-RXN$ACONITATEHYDR-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:25:30 no Catalyses the reversible isomerization of citrate to isocitrate via cis-aconitate. Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). 2 vladimir 0.239366 0.3009 0.256767 0.203016 0.557618 0.442382 0.2471 0.205336 0.390951 0.156613 0.596288 0.403712 0.290023 0.267981 0.160093 0.281903 0.428074 0.571926 0.180974 0.429234 0.219258 0.170534 0.648492 0.351508 0.791221 92708.71 -0.121487 0.31475 0.54007 0.220674 0.076655 0.583043 0.416957 0.24971 0.121951 0.127758 5.424583 9.328688 NMV_0829 2191791 CDS -2 810322 811392 1071 validated/Curated no putative lipooligosaccharide export system permease protein LptG 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 1.6.3 : Lipopolysaccharide ; 2020-04-22 17:15:43 no 18375759 Part of the ABC transporter complex involved in the translocation of lipopooligosaccharide (LOS) from the inner membrane to the outer membrane. 2 vladimir 0.239963 0.3128 0.236228 0.211018 0.54902 0.45098 0.305322 0.22409 0.316527 0.154062 0.540616 0.459384 0.246499 0.215686 0.190476 0.347339 0.406162 0.593838 0.168067 0.498599 0.201681 0.131653 0.70028 0.29972 0.688993 39359.695 0.31573 0.303371 0.457865 0.272472 0.11236 0.632022 0.367978 0.179775 0.109551 0.070225 9.554024 8.808989 NMV_0830 2191792 CDS -3 811389 812504 1116 validated/Curated no putative lipooligosaccharide export system permease protein LptF 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 1.6.3 : Lipopolysaccharide ; 2020-02-19 15:31:06 no 18375759 2 vladimir 0.222222 0.2903 0.25 0.237455 0.540323 0.459677 0.27957 0.241935 0.284946 0.193548 0.526882 0.473118 0.239247 0.185484 0.19086 0.384409 0.376344 0.623656 0.147849 0.443548 0.274194 0.134409 0.717742 0.282258 0.652231 41809.61 0.34097 0.256065 0.444744 0.307278 0.118598 0.614555 0.385445 0.183288 0.113208 0.070081 9.616402 8.773585 NMV_0831 2191793 CDS +1 812674 814080 1407 validated/Curated no pepA cytosol aminopeptidase (leucine aminopeptidase; LAP; leucyl aminopeptidase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 3.4.11.1 3.4.11.1-RXN PWY-5988$PWY-6018 2018-01-19 10:58:25 no Catalyses the release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. 2 vladimir 0.250178 0.2942 0.259417 0.196162 0.55366 0.44634 0.249467 0.170576 0.426439 0.153518 0.597015 0.402985 0.307036 0.289979 0.138593 0.264392 0.428571 0.571429 0.19403 0.422175 0.21322 0.170576 0.635394 0.364606 0.740116 49742.625 0.035256 0.361111 0.568376 0.207265 0.09188 0.594017 0.405983 0.217949 0.100427 0.117521 5.044868 9.264957 NMV_0832 2191794 CDS +3 814143 814583 441 validated/Curated no holC DNA polymerase III chi subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:11:39 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 2 vladimir 0.210884 0.2857 0.278912 0.22449 0.564626 0.435374 0.22449 0.231293 0.360544 0.183673 0.591837 0.408163 0.258503 0.238095 0.210884 0.292517 0.44898 0.55102 0.14966 0.387755 0.265306 0.197279 0.653061 0.346939 0.683962 16449.235 -0.146575 0.287671 0.472603 0.205479 0.123288 0.589041 0.410959 0.260274 0.123288 0.136986 5.193336 10.109589 NMV_0833 2191795 CDS +3 814842 815648 807 validated/Curated no putative membrane-associated peptidyl-prolyl isomerase (peptidyl-prolyl cis-trans isomerase; PPIase; rotamase; cyclophilin; FKBP65) 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-19 10:59:29 no Is a lipoprotein that accelerates protein folding by catalysing the following reaction: peptidylproline (omega=180) <=> peptidylproline (omega=0). 2 vladimir 0.302354 0.2726 0.261462 0.163569 0.534077 0.465923 0.301115 0.167286 0.416357 0.115242 0.583643 0.416357 0.371747 0.263941 0.130112 0.234201 0.394052 0.605948 0.234201 0.386617 0.237918 0.141264 0.624535 0.375465 0.763616 28536.175 -0.403731 0.343284 0.522388 0.175373 0.059701 0.526119 0.473881 0.257463 0.126866 0.130597 5.727394 8.86194 NMV_0834 2191796 CDS +1 815659 816381 723 validated/Curated no purN phosphoribosylglycinamide formyltransferase (GART; GAR transformylase; 5'-phosphoribosylglycinamide transformylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 1.5.3.2 : Folic acid ; 2.1.2.2 GART-RXN PWY-6121$PWY-6613 2018-01-30 10:01:10 no Uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. 2 vladimir 0.22488 0.2743 0.266348 0.23445 0.54067 0.45933 0.267943 0.200957 0.38756 0.143541 0.588517 0.411483 0.258373 0.263158 0.172249 0.30622 0.435407 0.564593 0.148325 0.358852 0.239234 0.253589 0.598086 0.401914 0.669757 22379.825 0.191346 0.331731 0.548077 0.240385 0.091346 0.605769 0.394231 0.225962 0.115385 0.110577 5.605522 9.759615 NMV_0835 2191797 CDS +1 816400 817068 669 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2015-11-21 12:07:11 no 1 vladimir 0.266369 0.2768 0.255952 0.200893 0.532738 0.467262 0.316964 0.169643 0.334821 0.178571 0.504464 0.495536 0.308036 0.267857 0.174107 0.25 0.441964 0.558036 0.174107 0.392857 0.258929 0.174107 0.651786 0.348214 0.635798 24092.68 -0.196861 0.358744 0.542601 0.192825 0.116592 0.58296 0.41704 0.201794 0.134529 0.067265 9.671837 9 NMV_0836 2191798 CDS +1 817186 817608 423 validated/Curated no putative OsmC-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-03-23 15:33:59 no Osmotically inducible protein C (OsmC) is a stress-induced protein found in E. coli. 1 vladimir 0.248227 0.2151 0.321513 0.21513 0.536643 0.463357 0.276596 0.141844 0.41844 0.163121 0.560284 0.439716 0.276596 0.255319 0.191489 0.276596 0.446809 0.553191 0.191489 0.248227 0.35461 0.205674 0.602837 0.397163 0.617383 14984.675 -0.015714 0.378571 0.535714 0.192857 0.085714 0.557143 0.442857 0.278571 0.157143 0.121429 7.122246 9.35 NMNmiscRNA0064 52714373 misc_RNA -1 817684 817771 88 validated/Curated no Bns1 RNA 1b : Function from experimental evidences in the studied species 2018-01-28 19:18:49 22984255, 28334889 Small RNA found to be blood-induced. vladimir NMV_0837 2191799 CDS +2 818177 818893 717 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-19 11:00:59 no Belongs to the helix-turn-helix (HTH) GntR family of transcriptional regulators. 1 vladimir 0.217573 0.2762 0.287308 0.218968 0.563459 0.436541 0.242678 0.267782 0.338912 0.150628 0.606695 0.393305 0.313808 0.1841 0.167364 0.334728 0.351464 0.648536 0.096234 0.376569 0.355649 0.171548 0.732218 0.267782 0.650134 27197.295 -0.226891 0.222689 0.441176 0.277311 0.084034 0.504202 0.495798 0.331933 0.176471 0.155462 6.011726 9.978992 NMV_0838 2191800 CDS +3 819042 819944 903 validated/Curated no putative lysine exporter LysO 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 18:30:35 no Might mediate export of lysine. 1 vladimir 0.142857 0.2115 0.345515 0.300111 0.557032 0.442968 0.189369 0.182724 0.378738 0.249169 0.561462 0.438538 0.129568 0.209302 0.212625 0.448505 0.421927 0.578073 0.109635 0.242525 0.445183 0.202658 0.687708 0.312292 0.569643 31871.875 0.995333 0.323333 0.54 0.336667 0.103333 0.736667 0.263333 0.12 0.07 0.05 9.375221 8.33 NMV_0839 2191801 CDS +3 819987 820760 774 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-19 11:03:26 no Belongs to the DeoR family of HTH-type transcriptional regulators, involved in sugar catabolism. 1 vladimir 0.22093 0.2842 0.301034 0.193798 0.585271 0.414729 0.27907 0.217054 0.387597 0.116279 0.604651 0.395349 0.271318 0.217054 0.20155 0.310078 0.418605 0.581395 0.112403 0.418605 0.313953 0.155039 0.732558 0.267442 0.603086 28076.95 -0.105447 0.307393 0.533074 0.249027 0.07393 0.525292 0.474708 0.280156 0.151751 0.128405 6.483513 9.478599 NMV_0840 2191802 CDS +3 820839 822560 1722 validated/Curated no glnS glutamine-tRNA ligase (glutaminyl-tRNA synthetase; GlnRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.18 GLUTAMINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:45:22 no Catalyses the attachment of glutamine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.262285 0.2984 0.241563 0.19775 0.539964 0.460036 0.250444 0.230906 0.348135 0.170515 0.579041 0.420959 0.369449 0.198934 0.181172 0.250444 0.380107 0.619893 0.166963 0.465364 0.195382 0.172291 0.660746 0.339254 0.790256 64803.645 -0.673132 0.234875 0.47153 0.188612 0.137011 0.501779 0.498221 0.338078 0.174377 0.163701 5.827583 10.104982 NMV_0841 2191803 CDS +2 822653 823609 957 validated/Curated no gshB glutathione synthetase (glutathione synthase; GSH synthetase; GSH-S; GSHase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.10 : Glutathione ; 6.3.2.3 GLUTATHIONE-SYN-RXN GLUTATHIONESYN-PWY$PWY-4041 2018-01-19 11:05:53 no Catalyses the second step in the glutathione biosynthesis pathway: ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + phosphate + glutathione. 2 vladimir 0.248694 0.2832 0.270637 0.197492 0.553814 0.446186 0.278997 0.216301 0.373041 0.131661 0.589342 0.410658 0.275862 0.23511 0.178683 0.310345 0.413793 0.586207 0.191223 0.398119 0.260188 0.15047 0.658307 0.341693 0.723933 34997.985 -0.071384 0.308176 0.490566 0.213836 0.09434 0.575472 0.424528 0.245283 0.128931 0.116352 7.119148 9.41195 NMV_0842 2191804 CDS +1 823921 824304 384 validated/Curated no dgk diacylglycerol kinase (DAGK; diglyceride kinase; DGK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.1.107 DIACYLGLYKIN-RXN 2018-01-19 11:06:13 no Catalyses the formation of phosphatidic acid from diacylglycerol and ATP, an important step in phospholipid biosynthesis. 2 vladimir 0.197917 0.2734 0.278646 0.25 0.552083 0.447917 0.1875 0.15625 0.421875 0.234375 0.578125 0.421875 0.226562 0.304688 0.132812 0.335938 0.4375 0.5625 0.179688 0.359375 0.28125 0.179688 0.640625 0.359375 0.775912 13800.54 0.538583 0.354331 0.511811 0.251969 0.133858 0.661417 0.338583 0.19685 0.110236 0.086614 8.079277 9.031496 NMV_0843 2191805 CDS +2 824597 825070 474 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-08 17:54:03 no 2 vladimir 0.28903 0.2637 0.274262 0.172996 0.537975 0.462025 0.28481 0.189873 0.424051 0.101266 0.613924 0.386076 0.348101 0.202532 0.158228 0.291139 0.360759 0.639241 0.234177 0.398734 0.240506 0.126582 0.639241 0.360759 0.769382 16963.87 -0.280255 0.292994 0.503185 0.197452 0.10828 0.56051 0.43949 0.299363 0.191083 0.10828 8.848961 9.592357 NMV_0844 2191806 CDS +1 825196 826299 1104 validated/Curated no mnmA trmU tRNA-specific 2-thiouridylase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.8.1.13 RXN0-2023 2018-01-19 11:09:26 no Catalyses the formation of the 2-thiouridine modification in the wobble position of tRNA(Gln), tRNA(Lys) and tRNA(Glu). 2 vladimir 0.246377 0.2763 0.262681 0.214674 0.538949 0.461051 0.244565 0.217391 0.36413 0.173913 0.581522 0.418478 0.334239 0.203804 0.184783 0.277174 0.388587 0.611413 0.160326 0.407609 0.23913 0.192935 0.646739 0.353261 0.695825 40883.99 -0.273569 0.280654 0.506812 0.212534 0.117166 0.569482 0.430518 0.258856 0.128065 0.13079 5.546028 9.577657 NMV_0845 2191807 CDS +2 826370 828040 1671 validated/Curated no fadD1 long-chain-fatty-acid-CoA-ligase (long-chain acyl-CoA synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.1.2 : Fatty acids (fatty acid oxidation) ; 6.2.1.3 ACYLCOASYN-RXN$R223-RXN$RXN-12702$RXN-12746$RXN-7904$RXN-9623$RXN-9644$RXN-9673 FAO-PWY$PWY-5143$PWY-6944$PWY-6945$PWY-6946 2020-02-19 18:17:53 no Catalyses the following reaction: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA. 2 vladimir 0.272292 0.2621 0.256134 0.209455 0.518253 0.481747 0.298025 0.186715 0.362657 0.152603 0.549372 0.450628 0.319569 0.206463 0.156194 0.317774 0.362657 0.637343 0.199282 0.393178 0.249551 0.157989 0.642729 0.357271 0.712639 61527.815 -0.089568 0.266187 0.489209 0.253597 0.088129 0.564748 0.435252 0.248201 0.133094 0.115108 8.343956 9.296763 NMV_0846 2191808 CDS +2 828152 829786 1635 validated/Curated no pyrG CTP synthase (UTP-ammonia ligase; CTP synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 6.3.4.2 CTPSYN-RXN PWY-5687 2020-04-21 15:18:06 no Catalyses the following reaction: ATP + UTP + NH(3) <=> ADP + phosphate + CTP synthase. Is involved in pyrimidine ribonucleotide/ribonucleoside metabolism. 2 vladimir 0.255657 0.2979 0.252599 0.193884 0.550459 0.449541 0.278899 0.188991 0.381651 0.150459 0.570642 0.429358 0.321101 0.207339 0.179817 0.291743 0.387156 0.612844 0.166972 0.497248 0.19633 0.13945 0.693578 0.306422 0.784281 59954.925 -0.184191 0.290441 0.501838 0.233456 0.101103 0.549632 0.450368 0.268382 0.136029 0.132353 5.635109 9.630515 NMV_0847 2191809 CDS +1 830014 830331 318 validated/Curated partial truncated ISNme1 transposase (N-terminal 30% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-19 11:11:10 no Belongs to the IS5 family. 2 vladimir 0.251572 0.3270 0.201258 0.220126 0.528302 0.471698 0.245283 0.358491 0.216981 0.179245 0.575472 0.424528 0.320755 0.160377 0.188679 0.330189 0.349057 0.650943 0.188679 0.462264 0.198113 0.150943 0.660377 0.339623 0.602653 12577.07 -0.29619 0.180952 0.371429 0.247619 0.161905 0.52381 0.47619 0.285714 0.161905 0.12381 7.094154 9.085714 NMV_0848 2191810 CDS +1 831373 833589 2217 validated/Curated no lbpB lactoferrin-binding protein B (LbpB) 2b : Function from indirect experimental evidences (e.g. phenotypes) rc : receptor 8 : Outer membrane-associated 2008-05-08 17:52:55 no 1 vladimir 0.304014 0.2147 0.262066 0.219215 0.47677 0.52323 0.273342 0.162382 0.424899 0.139378 0.58728 0.41272 0.388363 0.2341 0.169147 0.20839 0.403248 0.596752 0.250338 0.247632 0.192152 0.309878 0.439783 0.560216 0.611444 80300.355 -0.749187 0.304878 0.539295 0.162602 0.084011 0.493225 0.506775 0.311653 0.130081 0.181572 4.710335 9.638211 NMV_0849 2191811 CDS +3 833586 836423 2838 validated/Curated no lbpA lactoferrin-binding protein A (LbpA) 1b : Function from experimental evidences in the studied species rc : receptor 8 : Outer membrane-associated 2008-05-12 12:53:55 no 9596785 1 vladimir 0.264623 0.2512 0.284355 0.199789 0.535588 0.464412 0.267442 0.183932 0.350951 0.197674 0.534884 0.465116 0.353066 0.212474 0.226216 0.208245 0.438689 0.561311 0.173362 0.357294 0.275899 0.193446 0.633192 0.366808 0.614328 105609.64 -0.724339 0.318519 0.511111 0.162963 0.125926 0.501587 0.498413 0.280423 0.164021 0.116402 9.393272 9.633862 NMV_0850 2191812 CDS -2 837742 838746 1005 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 11:11:59 no Belongs to the IS5 family. 2 vladimir 0.283582 0.2985 0.228856 0.189055 0.527363 0.472637 0.283582 0.298507 0.268657 0.149254 0.567164 0.432836 0.358209 0.208955 0.191045 0.241791 0.4 0.6 0.208955 0.38806 0.226866 0.176119 0.614925 0.385075 0.653044 38340.475 -0.594311 0.272455 0.42515 0.197605 0.11976 0.488024 0.511976 0.293413 0.185629 0.107784 9.487587 9.314371 NMV_0851 2191813 CDS -3 838893 840821 1929 validated/Curated no rpoD RNA polymerase sigma factor RpoD (Sigma-70) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-19 11:12:36 no Is known as the major or primary sigma factor. 2 vladimir 0.314152 0.2836 0.232245 0.170036 0.515811 0.484189 0.317263 0.209953 0.359253 0.11353 0.569207 0.430793 0.390358 0.186625 0.147745 0.275272 0.33437 0.66563 0.234837 0.454121 0.189736 0.121306 0.643857 0.356143 0.735813 73829.685 -0.628505 0.224299 0.417445 0.219626 0.070093 0.448598 0.551402 0.367601 0.163551 0.20405 4.892021 9.780374 NMV_0852 2191814 CDS -3 841008 842780 1773 validated/Curated no dnaG DNA primase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.- RXN0-5021 2018-01-19 11:15:08 no Synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. 1 vladimir 0.259447 0.2510 0.274112 0.215454 0.525099 0.474901 0.238579 0.241963 0.338409 0.181049 0.580372 0.419628 0.358714 0.219966 0.150592 0.270728 0.370558 0.629442 0.181049 0.291032 0.333333 0.194585 0.624365 0.375635 0.616237 65967.635 -0.354746 0.264407 0.471186 0.208475 0.116949 0.549153 0.450847 0.262712 0.135593 0.127119 5.901283 9.20678 NMV_0853 2191815 CDS -2 842926 845676 2751 validated/Curated no secA protein translocase SecA subunit 2a : Function from experimental evidences in other organisms t : transporter 2 : Cytoplasmic 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:20:18 no Part of the prokaryotic protein translocation apparatus essential for protein export. 2 vladimir 0.270447 0.3097 0.240276 0.179571 0.549982 0.450018 0.251908 0.25518 0.370774 0.122137 0.625954 0.374046 0.370774 0.19193 0.158124 0.279171 0.350055 0.649945 0.188659 0.482007 0.19193 0.137405 0.673937 0.326063 0.743069 103339.365 -0.451638 0.253275 0.45524 0.220524 0.097162 0.498908 0.501092 0.295852 0.138646 0.157205 5.091652 9.804585 NMV_0854 2191816 CDS +2 845807 846229 423 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2020-04-23 18:20:39 no Belongs to the DUF721/UPF0232 family of proteins, which are not functionally characterised. 1 vladimir 0.224586 0.2388 0.323877 0.212766 0.562648 0.437352 0.219858 0.276596 0.340426 0.163121 0.617021 0.382979 0.269504 0.283688 0.148936 0.297872 0.432624 0.567376 0.184397 0.156028 0.482269 0.177305 0.638298 0.361702 0.511298 15141.225 -0.049286 0.292857 0.485714 0.264286 0.057143 0.578571 0.421429 0.264286 0.185714 0.078571 10.387474 8.707143 NMV_0855 2191817 CDS +1 846511 847062 552 validated/Curated no H.8 outer-membrane lipoprotein 1b : Function from experimental evidences in the studied species m : membrane component 8 : Outer membrane-associated 2008-05-12 12:55:04 no 2452958 2 vladimir 0.23913 0.2953 0.25 0.21558 0.54529 0.45471 0.23913 0.141304 0.48913 0.130435 0.630435 0.369565 0.304348 0.375 0.11413 0.206522 0.48913 0.51087 0.173913 0.369565 0.146739 0.309783 0.516304 0.483696 0.827456 18545.04 -0.065027 0.42623 0.655738 0.153005 0.065574 0.601093 0.398907 0.234973 0.098361 0.136612 4.646568 9.409836 NMV_0856 2191818 CDS +2 847157 847666 510 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:35:33 no Contains a emerythrin HHE cation-binding region. 2 vladimir 0.266667 0.2627 0.25098 0.219608 0.513726 0.486275 0.217647 0.247059 0.376471 0.158824 0.623529 0.376471 0.376471 0.205882 0.123529 0.294118 0.329412 0.670588 0.205882 0.335294 0.252941 0.205882 0.588235 0.411765 0.770615 19335.25 -0.257396 0.230769 0.431953 0.201183 0.142012 0.56213 0.43787 0.284024 0.12426 0.159763 4.861259 10.195266 NMV_0857 2191819 CDS +2 847700 848320 621 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:45:00 no 2 vladimir 0.267311 0.2609 0.244767 0.227053 0.505636 0.494364 0.222222 0.231884 0.294686 0.251208 0.52657 0.47343 0.410628 0.178744 0.169082 0.241546 0.347826 0.652174 0.169082 0.371981 0.270531 0.188406 0.642512 0.357488 0.739821 24469.625 -0.63301 0.208738 0.417476 0.174757 0.179612 0.519417 0.480583 0.291262 0.140777 0.150485 5.249413 9.553398 NMV_0858 2191820 CDS +1 848434 849579 1146 validated/Curated no dapE succinyl-diaminopimelate desuccinylase (SDAP) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 3.5.1.18 SUCCDIAMINOPIMDESUCC-RXN DAPLYSINESYN-PWY 2018-01-19 11:17:20 no Catalyses the hydrolysis of N-succinyl-L,L-diaminopimelic acid, which is required for the synthesis of lysine and meso-diaminopimelic acid. 2 vladimir 0.240838 0.2906 0.271379 0.197208 0.561955 0.438045 0.248691 0.209424 0.376963 0.164921 0.586387 0.413613 0.301047 0.253927 0.17801 0.267016 0.431937 0.568063 0.172775 0.408377 0.259162 0.159686 0.667539 0.332461 0.664979 41275.06 -0.214436 0.325459 0.538058 0.223097 0.094488 0.543307 0.456693 0.254593 0.125984 0.128609 5.422874 9.372703 NMV_0859 2191821 fCDS +3 850311 850418 108 validated/Curated partial truncated putative HTH-type transcriptional regulator (pseudogene part 1) 5 : Unknown function r : regulator 2 : Cytoplasmic 2018-01-19 11:17:34 no Belongs to one of the major subfamilies of transcription regulation proteins, which is related to the arabinose operon regulatory protein AraC, where almost all of these proteins seem to be positive transcriptional factors. 1 vladimir 0.181287 0.2281 0.350877 0.239766 0.578947 0.421053 0.210526 0.280702 0.298246 0.210526 0.578947 0.421053 0.192982 0.175439 0.298246 0.333333 0.473684 0.526316 0.140351 0.22807 0.45614 0.175439 0.684211 0.315789 0.411742 6464.475 0.001786 0.25 0.410714 0.321429 0.107143 0.589286 0.410714 0.285714 0.25 0.035714 12.006737 9.678571 NMV_0860 2191822 fCDS +2 850436 850849 414 validated/Curated partial truncated putative HTH-type transcriptional regulator (pseudogene part 2) 5 : Unknown function r : regulator 2 : Cytoplasmic 2018-01-19 11:18:31 no Belongs to one of the major subfamilies of transcription regulation proteins, which is related to the arabinose operon regulatory protein AraC, where almost all of these proteins seem to be positive transcriptional factors. 1 vladimir 0.188139 0.2597 0.357873 0.194274 0.617587 0.382413 0.177914 0.214724 0.447853 0.159509 0.662577 0.337423 0.263804 0.300613 0.184049 0.251534 0.484663 0.515337 0.122699 0.263804 0.441718 0.171779 0.705521 0.294479 0.563082 17212.775 0.088889 0.382716 0.574074 0.191358 0.092593 0.62963 0.37037 0.191358 0.080247 0.111111 4.654793 10.123457 NMV_0860.1 2662682 CDS -1 850901 851281 381 validated/Curated partial truncated conserved hypothetical periplasmic protein (N-terminal 70% of the protein) 5 : Unknown function u : unknown 9 : Periplasmic 2008-06-12 13:31:33 vladimir NMV_0861 2191823 CDS +3 851439 852308 870 validated/Curated no ogt methylated-DNA-protein-cysteine methyltransferase (6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1.63 2.1.1.63-RXN 2018-01-19 11:19:07 no Carries out the repair of DNA containing O6-alkylated guanine, the major mutagenic and carcinogenic effect of methylating agents in DNA. 1 vladimir 0.224691 0.2469 0.301235 0.22716 0.548148 0.451852 0.218519 0.237037 0.348148 0.196296 0.585185 0.414815 0.307407 0.192593 0.211111 0.288889 0.403704 0.596296 0.148148 0.311111 0.344444 0.196296 0.655556 0.344444 0.591665 30432.05 -0.237918 0.267658 0.438662 0.226766 0.096654 0.568773 0.431227 0.271375 0.148699 0.122677 8.643349 9.944238 NMV_tRNA_25 2194840 tRNA +1 852499 852574 76 validated/Curated no Asn tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:53:49 no tRNA Asn anticodon GTT. vladimir NMV_0862 2191824 CDS +3 852705 853715 1011 validated/Curated no rfaF ADP-heptose:LPS heptosyltransferase II 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.-.-.- RXN0-5061 LIPA-CORESYN-PWY 2018-01-19 11:19:40 no 12618369, 7746148 Is involved in the lipooligosaccharide core biosynthesis. 1 vladimir 0.203759 0.2166 0.326409 0.253215 0.543027 0.456973 0.225519 0.204748 0.347181 0.222552 0.551929 0.448071 0.267062 0.21365 0.225519 0.293769 0.439169 0.560831 0.118694 0.231454 0.406528 0.243323 0.637982 0.362018 0.558757 37479.785 -0.132738 0.28869 0.497024 0.229167 0.110119 0.580357 0.419643 0.27381 0.145833 0.127976 6.345085 9.565476 NMV_0863 2191825 CDS +3 853770 854216 447 validated/Curated no smpB SsrA-binding protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2020-02-21 16:09:05 no SmpB, a unique RNA-binding protein, is a key component of the SsrA quality-control system. SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the addition of a short peptide tag to the C-terminus of the partially synthesised nascent polypeptide chain. The SsrA-tagged protein is then degraded by C-terminal-specific proteases. 1 vladimir 0.308725 0.2192 0.252796 0.219239 0.472036 0.527964 0.322148 0.201342 0.302013 0.174497 0.503356 0.496644 0.375839 0.181208 0.174497 0.268456 0.355705 0.644295 0.228188 0.275168 0.281879 0.214765 0.557047 0.442953 0.664362 17178.445 -0.560135 0.22973 0.371622 0.216216 0.121622 0.5 0.5 0.364865 0.25 0.114865 9.999001 8.932432 NMNmiscRNA0148 54905461 misc_RNA -1 854268 854414 147 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 10:42:04 28334889 Function unknown. vladimir NMV_0865 2191827 fCDS +2 854588 854737 150 validated/Curated pseudo autB putative autotransporter B (pseudogene part 1) 1b : Function from experimental evidences in the studied species f : factor 7 : Outer membrane protein 2018-03-23 15:36:19 no 10972828 Belongs to the family of autotransporters where the signal that mediates secretion through the outer-membrane is contained within the C-terminus of the secreted protein itself. The N-terminal part of the protein contains a pectin lyase fold and might adopt a beta-helix topology found in many virulence factors. 3 vladimir 0.32197 0.1667 0.159091 0.352273 0.325758 0.674242 0.318182 0.170455 0.204545 0.306818 0.375 0.625 0.363636 0.147727 0.125 0.363636 0.272727 0.727273 0.284091 0.181818 0.147727 0.386364 0.329545 0.670455 0.46604 10340.86 -0.124138 0.195402 0.356322 0.264368 0.149425 0.517241 0.482759 0.310345 0.183908 0.126437 9.353966 7.183908 NMV_0866 2191828 fCDS +3 854736 856760 2025 validated/Curated pseudo autB putative autotransporter B (pseudogene part 2) 1b : Function from experimental evidences in the studied species f : factor 7 : Outer membrane protein 2018-03-23 15:36:24 no 10972828 Belongs to the family of autotransporters where the signal that mediates secretion through the outer-membrane is contained within the C-terminus of the secreted protein itself. The N-terminal part of the protein contains a pectin lyase fold and might adopt a beta-helix topology found in many virulence factors. 3 vladimir 0.324365 0.2018 0.203288 0.270553 0.405082 0.594918 0.303438 0.189836 0.301943 0.204783 0.491779 0.508221 0.366218 0.195815 0.180867 0.2571 0.376682 0.623318 0.303438 0.219731 0.127055 0.349776 0.346786 0.653214 0.556021 75867.585 -0.515269 0.270958 0.482036 0.203593 0.140719 0.504491 0.495509 0.251497 0.148204 0.103293 9.227821 9.208084 NMV_0868 2191830 CDS -3 856941 858308 1368 validated/Curated no putative FAD-linked oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-23 18:31:59 no Oxygen-dependent oxidoreductase containing a covalently bound FAD group. Similar to an E. coli enzyme that catalyses the oxidation of glycolate to glyoxylate. 2 vladimir 0.259503 0.2982 0.221491 0.22076 0.519737 0.480263 0.27193 0.263158 0.307018 0.157895 0.570175 0.429825 0.296053 0.214912 0.188596 0.300439 0.403509 0.596491 0.210526 0.416667 0.16886 0.203947 0.585526 0.414474 0.637028 50397.64 -0.129451 0.292308 0.494505 0.250549 0.101099 0.534066 0.465934 0.246154 0.131868 0.114286 6.074959 9.118681 NMV_0869 2191831 CDS -2 858418 858654 237 validated/Curated no H.8-like outer-membrane lipoprotein 1b : Function from experimental evidences in the studied species m : membrane component 8 : Outer membrane-associated 2008-05-12 12:57:41 no 2497298 2 vladimir 0.202532 0.3376 0.261603 0.198312 0.599156 0.400844 0.101266 0.126582 0.670886 0.101266 0.797468 0.202532 0.21519 0.64557 0.037975 0.101266 0.683544 0.316456 0.291139 0.240506 0.075949 0.392405 0.316456 0.683544 0.826037 7195.775 0.30641 0.589744 0.705128 0.076923 0.012821 0.730769 0.269231 0.205128 0.051282 0.153846 4.179482 10 NMV_0870 2191832 CDS +2 859127 859609 483 validated/Curated no putative FKBP-type peptidyl-prolyl cis-trans isomerase SlyD 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-22 17:21:29 no SlyD is a folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins. 2 vladimir 0.221532 0.2402 0.308489 0.229814 0.548654 0.451346 0.167702 0.186335 0.521739 0.124224 0.708075 0.291925 0.385093 0.198758 0.130435 0.285714 0.329193 0.670807 0.111801 0.335404 0.273292 0.279503 0.608696 0.391304 0.752982 17404.495 -0.3075 0.25 0.56875 0.225 0.1375 0.55625 0.44375 0.34375 0.1375 0.20625 4.528328 10.025 NMV_0871 2191833 CDS +1 859696 860508 813 validated/Curated no putative phytoene synthase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.5.1.- 2.5.1.32-RXN$RXN-12245$RXNARA-8002 PWY-5942$PWY-6287 2018-01-19 11:23:04 no Catalyses the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. 1 vladimir 0.183575 0.1944 0.35628 0.2657 0.550725 0.449275 0.166667 0.206522 0.394928 0.231884 0.601449 0.398551 0.271739 0.213768 0.206522 0.307971 0.42029 0.57971 0.112319 0.163043 0.467391 0.257246 0.630435 0.369565 0.569961 30691.42 -0.047636 0.276364 0.476364 0.236364 0.101818 0.614545 0.385455 0.272727 0.149091 0.123636 8.555443 9.716364 NMV_0872 2191834 CDS -3 860580 861050 471 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:36:53 no 2 vladimir 0.2569 0.3163 0.254777 0.171975 0.571125 0.428875 0.210191 0.33758 0.318471 0.133758 0.656051 0.343949 0.363057 0.184713 0.184713 0.267516 0.369427 0.630573 0.197452 0.426752 0.261146 0.11465 0.687898 0.312102 0.682844 18276.015 -0.566026 0.217949 0.384615 0.211538 0.147436 0.512821 0.487179 0.314103 0.166667 0.147436 5.7714 10.378205 NMV_0873 2191835 CDS +3 861177 862982 1806 validated/Curated no dsbD thiol:disulfide interchange protein DsbD (protein-disulfide reductase; disulfide reductase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.8.1.8 1.6.4.4-RXN 2018-01-19 11:23:50 no Catalyses the following reaction: protein dithiol + NAD(P)(+) <=> protein disulfide + NAD(P). Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. 1 vladimir 0.191584 0.2641 0.294574 0.249723 0.558693 0.441307 0.202658 0.214286 0.378738 0.204319 0.593023 0.406977 0.255814 0.249169 0.166113 0.328904 0.415282 0.584718 0.116279 0.328904 0.33887 0.215947 0.667774 0.332226 0.660233 64905.82 0.303494 0.314476 0.530782 0.246256 0.131448 0.670549 0.329451 0.176373 0.094842 0.081531 6.448906 9.044925 NMV_0875 2191837 CDS -1 863618 864814 1197 validated/Curated no ackA1 acetate kinase 1 (acetokinase 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.3.5 : Fermentation ; 2.7.2.1 ACETATEKIN-RXN$RXN-7958 FERMENTATION-PWY$PWY-5482$PWY-5485$PWY0-1312 2018-01-29 22:28:01 no Catalyses the following reaction: ATP + acetate <=> ADP + acetyl phosphate. 2 vladimir 0.236424 0.3283 0.252297 0.182957 0.580618 0.419382 0.26817 0.200501 0.398496 0.132832 0.598997 0.401002 0.293233 0.210526 0.18797 0.308271 0.398496 0.601504 0.14787 0.573935 0.170426 0.107769 0.744361 0.255639 0.797492 42388.795 0.067085 0.334171 0.525126 0.251256 0.090452 0.58794 0.41206 0.243719 0.125628 0.11809 5.733055 9.060302 NMV_0876 2191838 CDS +1 865165 865464 300 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 17:35:34 no 1 vladimir 0.24 0.2267 0.27 0.263333 0.496667 0.503333 0.21 0.25 0.34 0.2 0.59 0.41 0.32 0.17 0.19 0.32 0.36 0.64 0.19 0.26 0.28 0.27 0.54 0.46 0.557425 11319.3 -0.30101 0.242424 0.454545 0.212121 0.161616 0.535354 0.464646 0.262626 0.121212 0.141414 5.001823 9.636364 NMV_0877 2191839 CDS +3 865464 865649 186 validated/Curated no putative cytochrome cbb3 oxidase maturation protein 3 : Putative function from multiple computational evidences f : factor 5 : Inner membrane protein 2018-01-19 11:25:20 no Cytochrome cbb3 oxidases are found almost exclusively in proteobacteria and represent a distinctive class of proton-pumping respiratory haem-copper oxidases (HCO). Expression of cytochrome cbb3 oxidase allows human pathogens to colonise anoxic tissues. 1 vladimir 0.268817 0.1667 0.295699 0.268817 0.462366 0.537634 0.322581 0.129032 0.322581 0.225806 0.451613 0.548387 0.306452 0.112903 0.209677 0.370968 0.322581 0.677419 0.177419 0.258065 0.354839 0.209677 0.612903 0.387097 0.646159 7144.92 -0.052459 0.196721 0.409836 0.245902 0.147541 0.557377 0.442623 0.295082 0.114754 0.180328 4.499168 8.688525 NMV_0878 2191840 CDS +1 865639 866949 1311 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 11:25:49 no Belongs to the major facilitator superfamily. 1 vladimir 0.172387 0.2342 0.292143 0.301297 0.526316 0.473684 0.240275 0.187643 0.329519 0.242563 0.517162 0.482838 0.171625 0.224256 0.187643 0.416476 0.411899 0.588101 0.105263 0.290618 0.359268 0.244851 0.649886 0.350114 0.651553 47447.605 0.812615 0.316514 0.493119 0.298165 0.144495 0.715596 0.284404 0.12156 0.082569 0.038991 9.778969 8.529817 NMV_0879 2191841 CDS +3 867105 867839 735 validated/Curated no dnaQ DNA polymerase III epsilon subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 RXN0-4961 2018-01-22 15:12:57 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 2 vladimir 0.234014 0.2776 0.306122 0.182313 0.583673 0.416327 0.244898 0.216327 0.408163 0.130612 0.62449 0.37551 0.310204 0.204082 0.195918 0.289796 0.4 0.6 0.146939 0.412245 0.314286 0.126531 0.726531 0.273469 0.667017 27132.975 -0.295082 0.286885 0.479508 0.209016 0.086066 0.545082 0.454918 0.307377 0.147541 0.159836 5.258385 10.360656 NMV_0880 2191842 CDS +2 867836 868525 690 validated/Curated no ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 9 : Periplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 2.7.7.60 2.7.7.60-RXN NONMEVIPP-PWY 2018-01-19 11:26:49 no Catalyses the third step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis, the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. 1 vladimir 0.230435 0.2696 0.304348 0.195652 0.573913 0.426087 0.234783 0.226087 0.413043 0.126087 0.63913 0.36087 0.278261 0.252174 0.178261 0.291304 0.430435 0.569565 0.178261 0.330435 0.321739 0.169565 0.652174 0.347826 0.609234 24616.28 -0.003493 0.318777 0.519651 0.262009 0.056769 0.572052 0.427948 0.248908 0.131004 0.117904 6.495796 9.353712 NMV_0881 2191843 CDS +3 868557 869039 483 validated/Curated no ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS; MECDP-synthase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 4.6.1.12 RXN0-302 NONMEVIPP-PWY 2018-01-19 11:27:12 no Is involved in the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis. 1 vladimir 0.244306 0.2692 0.293996 0.192547 0.563147 0.436853 0.254658 0.236025 0.416149 0.093168 0.652174 0.347826 0.298137 0.217391 0.186335 0.298137 0.403727 0.596273 0.180124 0.354037 0.279503 0.186335 0.63354 0.36646 0.59672 17018.795 0.051875 0.31875 0.51875 0.2625 0.075 0.6 0.4 0.2375 0.125 0.1125 5.926704 9.10625 NMV_0882 2191844 CDS +1 869116 869787 672 validated/Curated no rpiA ribose-5-phosphate isomerase A (phosphoriboisomerase A; PRI) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.3 : Pentose phosphate shunt, non-oxidative branch ; 5.3.1.6 RIB5PISOM-RXN NONOXIPENT-PWY 2018-01-19 11:27:35 no Catalyses the conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. 2 vladimir 0.275298 0.2619 0.254464 0.208333 0.516369 0.483631 0.28125 0.160714 0.410714 0.147321 0.571429 0.428571 0.325893 0.205357 0.160714 0.308036 0.366071 0.633929 0.21875 0.419643 0.191964 0.169643 0.611607 0.388393 0.720394 23919.34 -0.001794 0.309417 0.515695 0.26009 0.076233 0.569507 0.430493 0.246637 0.112108 0.134529 5.014427 8.991031 NMV_0883 2191845 CDS +3 869856 870527 672 validated/Curated no putative periplasmic nuclease 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 3.1.-.- 2020-04-20 20:02:08 no Is homologous to the S. aureus thermonuclease (TNase), which is a calcium-dependent enzyme that catalyses the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides. 1 vladimir 0.236467 0.2493 0.340456 0.173789 0.589744 0.410256 0.226496 0.196581 0.423077 0.153846 0.619658 0.380342 0.337607 0.226496 0.235043 0.200855 0.461538 0.538462 0.145299 0.324786 0.363248 0.166667 0.688034 0.311966 0.61363 25957.25 -0.659227 0.321888 0.515021 0.158798 0.11588 0.540773 0.459227 0.309013 0.193133 0.11588 9.778542 9.987124 NMV_0884 2191846 CDS +1 870706 871452 747 validated/Curated no putative amino acid ABC transporter permease protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 11:28:23 no Binding protein-dependent transport systems are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system. 1 vladimir 0.161981 0.2396 0.31593 0.282463 0.555556 0.444444 0.200803 0.24498 0.309237 0.24498 0.554217 0.445783 0.192771 0.24498 0.180723 0.381526 0.425703 0.574297 0.092369 0.228916 0.457831 0.220884 0.686747 0.313253 0.647306 27819.015 0.586694 0.290323 0.435484 0.306452 0.141129 0.693548 0.306452 0.16129 0.100806 0.060484 9.542702 9.145161 NMV_0885 2191847 CDS -3 872463 873881 1419 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 17:33:24 no 2 vladimir 0.211416 0.3164 0.246653 0.225511 0.563073 0.436927 0.241015 0.262156 0.306554 0.190275 0.56871 0.43129 0.264271 0.232558 0.162791 0.340381 0.395349 0.604651 0.128964 0.454545 0.270613 0.145877 0.725159 0.274841 0.693013 52947.915 0.217161 0.277542 0.463983 0.235169 0.154661 0.646186 0.353814 0.192797 0.114407 0.07839 8.796837 9.108051 NMV_0886 2191848 CDS -1 874424 876142 1719 validated/Curated no argS arginine-tRNA ligase (arginyl-tRNA synthetase; ArgRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.19 ARGININE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:46:19 no Catalyses the attachment of arginine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.2484 0.2938 0.265271 0.192554 0.559046 0.440954 0.21815 0.211169 0.417103 0.153578 0.628272 0.371728 0.338569 0.230366 0.148342 0.282723 0.378709 0.621291 0.188482 0.439791 0.230366 0.141361 0.670157 0.329843 0.776074 62651.485 -0.176573 0.297203 0.520979 0.22028 0.11014 0.562937 0.437063 0.258741 0.125874 0.132867 5.329201 9.288462 NMV_0887 2191849 CDS -3 876234 877442 1209 validated/Curated no pncB nicotinate phosphoribosyltransferase (NAPRTase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 6.3.4.21 NICOTINATEPRIBOSYLTRANS-RXN PYRIDNUCSAL-PWY 2018-01-19 10:31:31 no Catalyses the following reaction: nicotinate D-ribonucleotide + diphosphate <=> nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. It is the first enzyme in the salvage pathway of NAD biosynthesis from nicotinate (niacin). 1 vladimir 0.234905 0.3408 0.225806 0.198511 0.566584 0.433416 0.233251 0.287841 0.320099 0.158809 0.60794 0.39206 0.317618 0.191067 0.166253 0.325062 0.35732 0.64268 0.153846 0.543424 0.191067 0.111663 0.734491 0.265509 0.685713 46280.465 -0.198507 0.238806 0.437811 0.233831 0.141791 0.544776 0.455224 0.283582 0.149254 0.134328 6.166924 9.343284 NMV_0888 2191850 CDS -2 877483 878337 855 validated/Curated no putative segregation and condensation protein A (ScpA) 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-19 11:29:17 no ScpA, which along with ScpB interacts with SMC in vivo, is part of a complex that is required for chromosome condensation and segregation. 1 vladimir 0.226901 0.2749 0.276023 0.222222 0.550877 0.449123 0.210526 0.277193 0.354386 0.157895 0.631579 0.368421 0.291228 0.22807 0.14386 0.336842 0.37193 0.62807 0.178947 0.319298 0.329825 0.17193 0.649123 0.350877 0.631972 31896.825 0.057746 0.239437 0.440141 0.28169 0.105634 0.598592 0.401408 0.257042 0.126761 0.130282 5.422234 9.341549 NMV_0889 2191851 CDS -3 878508 879035 528 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-08 17:32:38 no 3 vladimir 0.363636 0.1155 0.149621 0.371212 0.265152 0.734848 0.357955 0.119318 0.232955 0.289773 0.352273 0.647727 0.346591 0.113636 0.142045 0.397727 0.255682 0.744318 0.386364 0.113636 0.073864 0.426136 0.1875 0.8125 0.410159 20811.89 0.347429 0.182857 0.365714 0.32 0.188571 0.634286 0.365714 0.217143 0.137143 0.08 9.13308 9.28 NMV_0890 2191852 CDS -1 879173 879949 777 validated/Curated no tcdA tRNA threonylcarbamoyladenosine dehydratase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 6.1.-.- 2018-01-19 11:30:27 no 23242255 Catalyses the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t6A37) to form cyclic t6A37 (ct6A37) in tRNAs that read codons beginning with adenine. 2 vladimir 0.223938 0.2909 0.279279 0.20592 0.570142 0.429858 0.208494 0.189189 0.401544 0.200772 0.590734 0.409266 0.266409 0.266409 0.196911 0.27027 0.46332 0.53668 0.196911 0.416988 0.239382 0.146718 0.656371 0.343629 0.701727 27622.295 -0.028295 0.364341 0.573643 0.205426 0.100775 0.585271 0.414729 0.22093 0.124031 0.096899 8.234795 9.534884 NMV_0891 2191853 CDS +2 880166 880630 465 validated/Curated no putative universal stress protein (Usp) 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-19 11:30:59 no Member of the Usp family, which are stress proteins, are predicted to be related to the MADS-box proteins and bind to DNA. The product of uspA has been shown to be a cytoplasmic serine and threonine phosphoprotein. Transcriptional induction of the uspA gene of E. coli occurs when conditions cause growth arrest; cells deficient in UspA survive poorly in stationary phase. 1 vladimir 0.232258 0.2688 0.292473 0.206452 0.56129 0.43871 0.219355 0.225806 0.451613 0.103226 0.677419 0.322581 0.322581 0.232258 0.148387 0.296774 0.380645 0.619355 0.154839 0.348387 0.277419 0.219355 0.625806 0.374194 0.687801 16581.175 0.006494 0.318182 0.512987 0.246753 0.090909 0.571429 0.428571 0.266234 0.12987 0.136364 5.272911 9.909091 NMV_0892 2191854 CDS +2 880712 881440 729 validated/Curated no rph ribonuclease PH (RNase PH; tRNA nucleotidyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.7.56 RXN0-6481$RXN0-6482$TRNA-NUCLEOTIDYLTRANSFERASE-RXN PWY0-1479 2018-01-19 11:31:33 no Is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates. 2 vladimir 0.23594 0.2757 0.277092 0.211248 0.552812 0.447188 0.234568 0.222222 0.399177 0.144033 0.621399 0.378601 0.26749 0.251029 0.193416 0.288066 0.444444 0.555556 0.205761 0.353909 0.238683 0.201646 0.592593 0.407407 0.695575 25709.255 -0.002893 0.338843 0.553719 0.252066 0.045455 0.566116 0.433884 0.235537 0.107438 0.128099 4.954185 9.264463 NMV_0893 2191855 CDS +2 881642 882859 1218 validated/Curated no lysC aspartokinase (aspartate kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 2.7.2.4 ASPARTATEKIN-RXN DAPLYSINESYN-PWY$HOMOSERSYN-PWY 2018-01-19 11:32:03 no Catalyses the phosphorylation of aspartate. The product of this reaction can be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine. 2 vladimir 0.260263 0.2808 0.262726 0.196223 0.543514 0.456486 0.273399 0.152709 0.44335 0.130542 0.596059 0.403941 0.293103 0.229064 0.17734 0.300493 0.406404 0.593596 0.214286 0.460591 0.167488 0.157635 0.628079 0.371921 0.760588 43440.57 -0.055802 0.328395 0.555556 0.249383 0.061728 0.540741 0.459259 0.271605 0.125926 0.145679 5.035042 9.375309 NMV_0894 2191856 CDS -2 884011 886779 2769 validated/Curated no putative TonB-dependent receptor 3 : Putative function from multiple computational evidences rc : receptor 7 : Outer membrane protein 2008-05-08 17:31:34 no 1 vladimir 0.287107 0.2521 0.244854 0.215962 0.49693 0.50307 0.304442 0.185265 0.295775 0.214518 0.48104 0.51896 0.370531 0.187432 0.214518 0.227519 0.40195 0.59805 0.186349 0.383532 0.224269 0.20585 0.607801 0.392199 0.627517 104236.395 -0.69718 0.303688 0.502169 0.157267 0.149675 0.495662 0.504338 0.248373 0.150759 0.097614 9.478935 9.316703 NMV_0895 2191857 CDS -3 888771 888965 195 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:31:24 no 2 vladimir 0.276923 0.2769 0.261538 0.184615 0.538462 0.461538 0.276923 0.261538 0.261538 0.2 0.523077 0.476923 0.384615 0.2 0.230769 0.184615 0.430769 0.569231 0.169231 0.369231 0.292308 0.169231 0.661538 0.338462 0.680307 7395.285 -0.770312 0.28125 0.5 0.140625 0.125 0.53125 0.46875 0.265625 0.21875 0.046875 9.897743 10.765625 NMV_0896 2191858 CDS -2 888955 891036 2082 validated/Curated no putative carbon starvation protein A 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-19 11:32:59 no Is one of the at least 30 E. coli proteins produced at the onset of carbon starvation. It has been suggested that CstA is involved in peptide utilisation. 2 vladimir 0.192123 0.2978 0.261287 0.248799 0.559078 0.440922 0.263689 0.18732 0.367435 0.181556 0.554755 0.445245 0.188761 0.257925 0.162824 0.39049 0.420749 0.579251 0.123919 0.448127 0.253602 0.174352 0.701729 0.298271 0.75243 74530.38 0.74531 0.326118 0.520924 0.291486 0.125541 0.707071 0.292929 0.147186 0.08658 0.060606 8.63459 8.883117 NMV_0898 2191860 CDS +3 891513 891893 381 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-08 17:30:58 no 1 vladimir 0.181102 0.2861 0.309711 0.223097 0.595801 0.404199 0.149606 0.181102 0.440945 0.228346 0.622047 0.377953 0.244094 0.275591 0.244094 0.23622 0.519685 0.480315 0.149606 0.401575 0.244094 0.204724 0.645669 0.354331 0.675614 13432.415 -0.233333 0.396825 0.603175 0.15873 0.119048 0.571429 0.428571 0.246032 0.134921 0.111111 6.458946 10.15873 NMV_0899 2191861 CDS -3 892026 892520 495 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:30:48 no 1 vladimir 0.30303 0.2040 0.236364 0.256566 0.440404 0.559596 0.29697 0.181818 0.309091 0.212121 0.490909 0.509091 0.345455 0.181818 0.187879 0.284848 0.369697 0.630303 0.266667 0.248485 0.212121 0.272727 0.460606 0.539394 0.571969 18697.525 -0.260366 0.262195 0.487805 0.231707 0.121951 0.530488 0.469512 0.262195 0.121951 0.140244 5.005775 9.402439 NMV_0900 2191862 CDS +3 892854 894287 1434 validated/Curated no gabD succinate-semialdehyde dehydrogenase [NADP+] (SSDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.31 : Aminobutyrate catabolism ; 1.2.1.24 SUCCSEMIALDDEHYDROG-RXN P105-PWY$PWY-6537 2018-01-27 18:39:41 no Catalyses the NAD+-dependent oxidation of succinate semialdehyde to succinate. 1 vladimir 0.238494 0.2462 0.30265 0.212692 0.548815 0.451185 0.246862 0.154812 0.422594 0.175732 0.577406 0.422594 0.282427 0.253138 0.192469 0.271967 0.445607 0.554393 0.186192 0.330544 0.292887 0.190377 0.623431 0.376569 0.69099 51259.64 -0.013208 0.348008 0.536688 0.218029 0.085954 0.597484 0.402516 0.236897 0.115304 0.121593 5.523064 9.366876 NMV_0901 2191863 CDS +1 894397 895185 789 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2018-01-19 11:34:58 no 11443078 Is homologous to a gene from D. nodosus named fimB (for fimbrial assembly), which was shown not to be involved in pilus biogenesis. 1 vladimir 0.250951 0.2269 0.299113 0.223067 0.525982 0.474018 0.281369 0.21673 0.34981 0.152091 0.56654 0.43346 0.292776 0.228137 0.163498 0.315589 0.391635 0.608365 0.178707 0.235741 0.38403 0.201521 0.619772 0.380228 0.602856 29185.055 0.015267 0.267176 0.461832 0.270992 0.099237 0.59542 0.40458 0.267176 0.148855 0.118321 8.966454 8.660305 NMV_0902 2191864 CDS +2 895553 897109 1557 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2018-01-19 11:35:18 no Contains a CBS (cystathionine-beta-synthase) module. 1 vladimir 0.228645 0.2717 0.280668 0.219011 0.552344 0.447656 0.244701 0.229287 0.391137 0.134875 0.620424 0.379576 0.27553 0.192678 0.163776 0.368015 0.356455 0.643545 0.165703 0.393064 0.287091 0.154143 0.680154 0.319846 0.656358 57330.135 0.223938 0.262548 0.46139 0.283784 0.096525 0.596525 0.403475 0.247104 0.106178 0.140927 4.782433 9.274131 NMV_0903 2191865 CDS +3 897126 897872 747 validated/Curated no surE 5'-nucleotidase SurE (nucleoside 5'-monophosphate phosphohydrolase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 5.6 : Protection ; 3.1.3.5 3-NUCLEOTID-RXN$5-NUCLEOTID-RXN$AMP-DEPHOSPHORYLATION-RXN$RXN-7607$RXN-7609 2018-01-19 11:36:51 no Is an acid phosphatase that catalyses the following reaction: 5'-ribonucleotide + H2O <=> ribonucleoside + phosphate. 1 vladimir 0.211513 0.2718 0.298527 0.218206 0.570281 0.429719 0.228916 0.188755 0.389558 0.192771 0.578313 0.421687 0.277108 0.269076 0.184739 0.269076 0.453815 0.546185 0.128514 0.35743 0.321285 0.192771 0.678715 0.321285 0.611108 27091.285 -0.135887 0.318548 0.564516 0.205645 0.120968 0.58871 0.41129 0.205645 0.08871 0.116935 4.745903 9.887097 NMV_0904 2191866 CDS +3 898128 899375 1248 validated/Curated no putative metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-19 11:37:25 no Is a lipoprotein. Belongs to MEROPS peptidase family M23 (clan M-), subfamily M23B. Contains a LysM domain found in a variety of enzymes involved in bacterial cell wall degradation. 1 vladimir 0.219551 0.3117 0.270032 0.198718 0.581731 0.418269 0.233173 0.225962 0.389423 0.151442 0.615385 0.384615 0.269231 0.370192 0.149038 0.211538 0.519231 0.480769 0.15625 0.338942 0.271635 0.233173 0.610577 0.389423 0.696225 42970.62 -0.191566 0.371084 0.66747 0.180723 0.084337 0.614458 0.385542 0.142169 0.091566 0.050602 9.436638 9.537349 NMV_0905 2191867 CDS -3 899736 900218 483 validated/Curated no putative acyl-CoA thioester hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.2.- PALMITOYL-COA-HYDROLASE-RXN 2018-01-19 11:37:55 no Belongs to the thioesterase superfamily. 2 vladimir 0.256729 0.3354 0.219462 0.188406 0.554865 0.445135 0.279503 0.254658 0.304348 0.161491 0.559006 0.440994 0.304348 0.204969 0.204969 0.285714 0.409938 0.590062 0.186335 0.546584 0.149068 0.118012 0.695652 0.304348 0.787317 17980.995 -0.245 0.29375 0.5 0.21875 0.09375 0.53125 0.46875 0.25 0.1375 0.1125 7.052071 10.1125 NMV_0906 2191868 CDS -1 900371 900532 162 validated/Curated no hypothetical membrane protein 5 : Unknown function u : unknown 5 : Inner membrane protein 2008-05-08 17:29:21 no 2 vladimir 0.203704 0.2963 0.234568 0.265432 0.530864 0.469136 0.148148 0.259259 0.351852 0.240741 0.611111 0.388889 0.222222 0.203704 0.166667 0.407407 0.37037 0.62963 0.240741 0.425926 0.185185 0.148148 0.611111 0.388889 0.647516 6164.06 0.350943 0.207547 0.45283 0.264151 0.188679 0.660377 0.339623 0.226415 0.150943 0.075472 9.687645 9.641509 NMV_0907 2191869 CDS -3 900606 901067 462 validated/Curated no recX regulatory protein RecX 2b : Function from indirect experimental evidences (e.g. phenotypes) r : regulator 2 : Cytoplasmic 2018-01-19 11:38:39 no It is suggested that the RecX protein might be regulator of RecA activity by interaction with the RecA protein or filament. 2 vladimir 0.309524 0.2836 0.246753 0.160173 0.530303 0.469697 0.246753 0.266234 0.331169 0.155844 0.597403 0.402597 0.402597 0.194805 0.201299 0.201299 0.396104 0.603896 0.279221 0.38961 0.207792 0.123377 0.597403 0.402597 0.690867 17790.41 -1.027451 0.248366 0.398693 0.163399 0.091503 0.418301 0.581699 0.385621 0.222222 0.163399 9.3498 9.45098 NMV_0908 2191870 CDS -1 901142 901852 711 validated/Curated no gph phosphoglycolate phosphatase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.1.1 : Carbohydrates/Carbon compounds ; 3.1.3.18 GPH-RXN 2018-01-22 15:51:52 no Catalyses the following reaction: 2-phosphoglycolate + H(2)O <=> glycolate + phosphate. 1 vladimir 0.243319 0.3122 0.254571 0.189873 0.566807 0.433193 0.227848 0.232068 0.405063 0.135021 0.637131 0.362869 0.320675 0.219409 0.151899 0.308017 0.371308 0.628692 0.181435 0.485232 0.206751 0.126582 0.691983 0.308017 0.742957 25669.345 -0.033051 0.275424 0.521186 0.258475 0.080508 0.59322 0.40678 0.258475 0.105932 0.152542 4.60833 9.199153 NMV_0909 2191871 CDS +3 902259 903524 1266 validated/Curated no gdhB NAD-specific glutamate dehydrogenase (NAD-GDH) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.1.3.4 : Glutamate degradation ; 1.4.1.2 GLUTAMATE-DEHYDROGENASE-RXN ALACAT2-PWY$GLUTAMATE-DEG1-PWY 2018-01-29 17:13:52 no Is involved in glutamate catabolism and catalyses the following reaction: L-glutamate + H(2)O + NAD(+) <=> 2-oxoglutarate + NH(3) + NADH. 2 vladimir 0.246445 0.2622 0.268562 0.222749 0.530806 0.469194 0.241706 0.170616 0.421801 0.165877 0.592417 0.407583 0.331754 0.225118 0.165877 0.277251 0.390995 0.609005 0.165877 0.390995 0.218009 0.225118 0.609005 0.390995 0.779893 46180.62 -0.174822 0.294537 0.539192 0.228029 0.106888 0.581948 0.418052 0.247031 0.118765 0.128266 5.313927 9.862233 NMV_0910 2191872 CDS -3 903582 904388 807 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-08 17:28:24 no 2 vladimir 0.296159 0.3259 0.215613 0.16233 0.541512 0.458488 0.297398 0.223048 0.330855 0.148699 0.553903 0.446097 0.371747 0.226766 0.163569 0.237918 0.390335 0.609665 0.219331 0.527881 0.152416 0.100372 0.680297 0.319703 0.744763 30165.795 -0.587313 0.287313 0.5 0.171642 0.141791 0.492537 0.507463 0.283582 0.164179 0.119403 7.347191 9.350746 NMV_0911 2191873 CDS +2 904733 904942 210 validated/Curated no putative tautomerase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.3.2.- 2018-01-19 11:40:37 no Catalyses the isomerisation of beta,gamma-unsaturated enones to their alpha,beta-isomers. 1 vladimir 0.309524 0.2190 0.314286 0.157143 0.533333 0.466667 0.328571 0.142857 0.471429 0.057143 0.614286 0.385714 0.314286 0.2 0.228571 0.257143 0.428571 0.571429 0.285714 0.314286 0.242857 0.157143 0.557143 0.442857 0.660731 7350.05 -0.36087 0.318841 0.57971 0.246377 0.028986 0.536232 0.463768 0.289855 0.144928 0.144928 6.446342 9.855072 NMV_0912 2191874 CDS +3 905031 906245 1215 validated/Curated no alaA glutamate-pyruvate aminotransferase AlaA 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.17 : Alanine ; 2.6.1.2 ALANINE-AMINOTRANSFERASE-RXN ALACAT2-PWY$ALANINE-SYN2-PWY 2018-01-19 11:42:07 no Catalyses the following reaction: L-alanine + 2-oxoglutarate <=> pyruvate + L-glutamate. 1 vladimir 0.246914 0.2691 0.255967 0.227984 0.525103 0.474897 0.271605 0.224691 0.330864 0.17284 0.555556 0.444444 0.330864 0.204938 0.155556 0.308642 0.360494 0.639506 0.138272 0.377778 0.281481 0.202469 0.659259 0.340741 0.675453 45442.745 -0.130941 0.247525 0.465347 0.242574 0.126238 0.591584 0.408416 0.252475 0.138614 0.113861 6.415154 9.574257 NMV_0913 2191875 CDS -1 906332 908848 2517 validated/Curated no clpB chaperone ClpB 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2020-04-21 10:35:30 no Is an ATP-binding protein that protects cells from stress by controlling the aggregation and denaturation of vital cellular structures. 1 vladimir 0.282878 0.2465 0.270885 0.199752 0.51737 0.48263 0.263027 0.21464 0.41067 0.111663 0.62531 0.37469 0.366005 0.183623 0.166253 0.284119 0.349876 0.650124 0.219603 0.341191 0.235732 0.203474 0.576923 0.423077 0.756292 89501.6 -0.417391 0.24472 0.46087 0.24472 0.059627 0.51677 0.48323 0.334161 0.163975 0.170186 5.484612 9.521739 NMV_0914 2191876 CDS +1 909172 910182 1011 validated/Curated no trpS tryptophan-tRNA ligase (tryptophanyl-tRNA synthetase; TrpRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.2 TRYPTOPHAN--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:47:00 no Catalyses the attachment of tryptophan to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.276954 0.3017 0.242334 0.179031 0.544016 0.455984 0.287834 0.210682 0.356083 0.145401 0.566766 0.433234 0.344214 0.243323 0.142433 0.27003 0.385757 0.614243 0.198813 0.451039 0.228487 0.121662 0.679525 0.320475 0.768988 37581.575 -0.38244 0.267857 0.47619 0.202381 0.092262 0.535714 0.464286 0.282738 0.142857 0.139881 5.770332 9.699405 NMV_0915 2191877 CDS +3 910188 910529 342 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 17:27:08 no 1 vladimir 0.239766 0.2807 0.295322 0.184211 0.576023 0.423977 0.210526 0.22807 0.394737 0.166667 0.622807 0.377193 0.350877 0.192982 0.22807 0.22807 0.421053 0.578947 0.157895 0.421053 0.263158 0.157895 0.684211 0.315789 0.724139 12338.34 -0.49646 0.309735 0.530973 0.185841 0.123894 0.566372 0.433628 0.265487 0.141593 0.123894 6.070366 9.849558 NMV_0916 2191878 CDS +3 910848 911171 324 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 17:26:56 no 2 vladimir 0.317901 0.2222 0.280864 0.179012 0.503086 0.496914 0.240741 0.046296 0.611111 0.101852 0.657407 0.342593 0.398148 0.425926 0.018519 0.157407 0.444444 0.555556 0.314815 0.194444 0.212963 0.277778 0.407407 0.592593 0.746524 10854.63 -0.305607 0.448598 0.616822 0.121495 0 0.504673 0.495327 0.336449 0.130841 0.205607 4.550652 9.299065 NMV_0917 2191879 CDS -2 911380 912888 1509 validated/Curated no putative exopolyphosphatase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.8.1 : Phosphorous metabolism ; 3.6.1.11 EXOPOLYPHOSPHATASE-RXN 2018-01-27 18:41:51 no Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has a strong preference for long-chain polyphosphates and has only weak affinity for smaller size polyP of about 15 residues. 2 vladimir 0.247846 0.3042 0.25381 0.194168 0.557985 0.442015 0.26839 0.228628 0.355865 0.147117 0.584493 0.415507 0.300199 0.220676 0.182903 0.296223 0.403579 0.596421 0.17495 0.463221 0.222664 0.139165 0.685885 0.314115 0.714863 55939.085 -0.176295 0.296813 0.464143 0.213147 0.099602 0.549801 0.450199 0.260956 0.141434 0.119522 7.281395 9.62749 NMV_0919 2191881 CDS -3 913005 913754 750 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-21 10:50:08 no 1 vladimir 0.230874 0.2719 0.290984 0.206284 0.562842 0.437158 0.25 0.233607 0.29918 0.217213 0.532787 0.467213 0.327869 0.172131 0.25 0.25 0.422131 0.577869 0.114754 0.409836 0.32377 0.151639 0.733607 0.266393 0.647028 27946.51 -0.595062 0.288066 0.465021 0.164609 0.176955 0.530864 0.469136 0.26749 0.176955 0.090535 9.811653 9.555556 NMV_0919.1 2609506 fCDS +1 915178 915273 96 validated/Curated pseudo opaC opacity protein C (pseudogene part 1) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-19 11:44:34 Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. vladimir NMV_0920 2191882 fCDS +2 915299 915991 693 validated/Curated pseudo opaC opacity protein C (pseudogene part 2) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-19 11:44:45 no Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. 2 vladimir 0.304473 0.2727 0.223665 0.199134 0.496393 0.503608 0.320346 0.190476 0.30303 0.186147 0.493507 0.506494 0.376623 0.212121 0.199134 0.212121 0.411255 0.588745 0.21645 0.415584 0.168831 0.199134 0.584416 0.415584 0.592788 26075.175 -0.776522 0.291304 0.504348 0.169565 0.165217 0.473913 0.526087 0.3 0.2 0.1 9.616829 9.186957 NMV_0921 2191883 CDS +1 917395 917811 417 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:26:17 no 1 vladimir 0.223022 0.2086 0.275779 0.292566 0.484412 0.515588 0.179856 0.251799 0.302158 0.266187 0.553957 0.446043 0.345324 0.165468 0.230216 0.258993 0.395683 0.604317 0.143885 0.208633 0.294964 0.352518 0.503597 0.496403 0.604279 16617.085 -0.569565 0.210145 0.413043 0.188406 0.23913 0.557971 0.442029 0.289855 0.173913 0.115942 7.276482 9.934783 NMV_0922 2191884 CDS +3 918111 918269 159 validated/Curated partial truncated ISNme1 transposase (C-terminal 15% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-08 17:26:07 no 2 vladimir 0.245283 0.2579 0.283019 0.213836 0.540881 0.459119 0.301887 0.245283 0.283019 0.169811 0.528302 0.471698 0.264151 0.207547 0.226415 0.301887 0.433962 0.566038 0.169811 0.320755 0.339623 0.169811 0.660377 0.339623 0.585053 5764.565 0.098077 0.346154 0.480769 0.230769 0.134615 0.576923 0.423077 0.211538 0.192308 0.019231 10.629509 8.961538 NMV_0924 2191886 CDS +3 918957 919580 624 validated/Curated no putative murein lytic transglycosylase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-19 11:47:16 no Might be involved in the degradation of murein via cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine, with the concomitant formation of a 1,6-anhydrobond in the muramic acid residue. 1 vladimir 0.200321 0.2772 0.314103 0.208333 0.591346 0.408654 0.25 0.269231 0.322115 0.158654 0.591346 0.408654 0.259615 0.192308 0.269231 0.278846 0.461538 0.538462 0.091346 0.370192 0.350962 0.1875 0.721154 0.278846 0.657516 23459.13 -0.336715 0.270531 0.478261 0.227053 0.096618 0.560386 0.439614 0.251208 0.164251 0.086957 10.425392 10.140097 NMV_0925 2191887 CDS +2 919688 921073 1386 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-18 18:52:19 no Belongs to the major facilitator superfamily of transporters. 1 vladimir 0.178211 0.2597 0.306638 0.255411 0.566378 0.433622 0.235931 0.21645 0.376623 0.170996 0.593074 0.406926 0.188312 0.248918 0.175325 0.387446 0.424242 0.575758 0.11039 0.313853 0.367965 0.207792 0.681818 0.318182 0.640971 48712.75 0.713232 0.342733 0.527115 0.301518 0.091106 0.694143 0.305857 0.13449 0.08026 0.05423 9.314873 8.642082 NMV_0926 2191888 CDS +1 921076 921600 525 validated/Curated no ssb single-stranded DNA-binding protein (SSB; helix-destabilizing protein) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.1 : DNA replication ; 2018-01-31 20:34:29 no Single-stranded DNA-binding proteins function in many processes including transcription, repair, replication and recombination. 2 vladimir 0.259048 0.3086 0.278095 0.154286 0.586667 0.413333 0.24 0.268571 0.377143 0.114286 0.645714 0.354286 0.36 0.217143 0.228571 0.194286 0.445714 0.554286 0.177143 0.44 0.228571 0.154286 0.668571 0.331429 0.695287 19408.875 -0.832759 0.275862 0.505747 0.155172 0.086207 0.528736 0.471264 0.270115 0.132184 0.137931 5.509285 10.632184 NMV_0927 2191889 CDS +3 922125 923048 924 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2008-05-08 17:25:20 no 1 vladimir 0.155844 0.2175 0.338745 0.287879 0.556277 0.443723 0.191558 0.194805 0.366883 0.246753 0.561688 0.438312 0.168831 0.256494 0.181818 0.392857 0.438312 0.561688 0.107143 0.201299 0.467532 0.224026 0.668831 0.331169 0.584453 32962.95 0.850814 0.34202 0.527687 0.299674 0.13355 0.726384 0.273616 0.127036 0.087948 0.039088 9.486092 8.700326 NMV_0928 2191890 CDS -2 923113 924501 1389 validated/Curated no fumC fumarate hydratase class II (fumarase C) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 4.2.1.2 FUMHYDR-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:29:33 no Involved in the TCA cycle. Catalyses the stereospecific interconversion of fumarate to L-malate. 1 vladimir 0.24406 0.3024 0.261339 0.192225 0.563715 0.436285 0.261339 0.198704 0.382289 0.157667 0.580994 0.419006 0.311015 0.267819 0.153348 0.267819 0.421166 0.578834 0.159827 0.440605 0.24838 0.151188 0.688985 0.311015 0.746839 49362.075 -0.127273 0.329004 0.556277 0.218615 0.084416 0.575758 0.424242 0.21645 0.112554 0.103896 5.835701 9.541126 NMV_0929 2191891 CDS -3 924642 926621 1980 validated/Curated no tkt transketolase (TK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.3 : Pentose phosphate shunt, non-oxidative branch ; 2.2.1.1 1TRANSKETO-RXN$2TRANSKETO-RXN$RXN-9583 NONOXIPENT-PWY$P21-PWY 2020-02-26 17:12:57 no Catalyses the following reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate. Wide specificity for both reactants, catalyses the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. 2 vladimir 0.255556 0.3091 0.250505 0.184848 0.559596 0.440404 0.254545 0.2 0.387879 0.157576 0.587879 0.412121 0.322727 0.24697 0.166667 0.263636 0.413636 0.586364 0.189394 0.480303 0.19697 0.133333 0.677273 0.322727 0.816316 71717.18 -0.195751 0.3217 0.534143 0.200303 0.115326 0.570561 0.429439 0.233687 0.116844 0.116844 5.500099 9.515933 NMV_0930 2191892 CDS +2 927149 928645 1497 validated/Curated no putative ferredoxin 3 : Putative function from multiple computational evidences c : carrier 11 : Membrane 1.4.3 : Electron carrier ; 2018-01-19 11:49:45 no Belongs to the 4Fe-4S family of ferredoxins, which are iron-sulphur proteins that mediate electron transfer in a range of metabolic reactions. 1 vladimir 0.244489 0.2639 0.271877 0.219773 0.535738 0.464262 0.270541 0.192385 0.350701 0.186373 0.543086 0.456914 0.270541 0.214429 0.208417 0.306613 0.422846 0.577154 0.192385 0.38477 0.256513 0.166333 0.641283 0.358717 0.702973 55651.635 0.041767 0.301205 0.475904 0.222892 0.126506 0.61245 0.38755 0.240964 0.13253 0.108434 8.427376 9.560241 NMV_0931 2191893 CDS +1 928648 929196 549 validated/Curated no conserved hypothetical membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2020-04-23 18:39:29 no Belongs to a family of proteins named after FixH, which has been implicated in nitrogen fixation in Rhizobium. 1 vladimir 0.251366 0.2587 0.28051 0.209472 0.539162 0.460838 0.278689 0.218579 0.36612 0.136612 0.584699 0.415301 0.349727 0.213115 0.147541 0.289617 0.360656 0.639344 0.125683 0.344262 0.327869 0.202186 0.672131 0.327869 0.650042 20595.625 -0.295055 0.236264 0.521978 0.225275 0.137363 0.549451 0.450549 0.258242 0.142857 0.115385 6.399559 9.445055 NMV_0932 2191894 CDS -3 929256 930431 1176 validated/Curated no putative dioxygenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 11:50:15 no Homologous to 2-nitropropane dioxygenase that catalyses the oxidation of nitroalkanes into their corresponding carbonyl compounds and nitrite, using either FAD or FMN as a cofactor. 1 vladimir 0.267857 0.2474 0.266156 0.218537 0.513605 0.486395 0.262755 0.193878 0.403061 0.140306 0.596939 0.403061 0.283163 0.232143 0.193878 0.290816 0.42602 0.57398 0.257653 0.316327 0.201531 0.22449 0.517857 0.482143 0.612101 41872.41 -0.05422 0.335038 0.529412 0.232737 0.076726 0.567775 0.432225 0.258312 0.140665 0.117647 7.753075 9.104859 NMV_tRNA_52 2194867 tRNA -1 930988 931062 75 validated/Curated no Glu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:54:05 no tRNA Glu anticodon TTC. vladimir NMV_tRNA_51 2194866 tRNA -1 931080 931156 77 validated/Curated no Arg tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:54:14 no tRNA Arg anticodon ACG. vladimir NMV_0933 2191895 CDS +2 931274 932659 1386 validated/Curated no putative DnaQ-like exonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 11:50:54 no Homologous to a variety of exonuclease proteins, including the epsilon subunit of DNA polymerase III. 1 vladimir 0.234253 0.1812 0.30644 0.278132 0.487615 0.512385 0.220807 0.157113 0.377919 0.244161 0.535032 0.464968 0.29724 0.216561 0.193206 0.292994 0.409766 0.590234 0.184713 0.169851 0.348195 0.29724 0.518047 0.481953 0.571961 52141.885 -0.113617 0.293617 0.504255 0.217021 0.129787 0.593617 0.406383 0.268085 0.140426 0.12766 6.110313 9.461702 NMV_0934 2191896 CDS -2 932869 933648 780 validated/Curated no putative ferredoxin-NADP reductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.18.1.2 1.18.1.2-RXN$FLAVONADPREDUCT-RXN PWY-101 2018-01-22 11:24:14 no Catalyses the following reaction: reduced ferredoxin + NADP(+) <=> oxidized ferredoxin + NADPH. 2 vladimir 0.247436 0.3205 0.207692 0.224359 0.528205 0.471795 0.253846 0.25 0.296154 0.2 0.546154 0.453846 0.288462 0.246154 0.153846 0.311538 0.4 0.6 0.2 0.465385 0.173077 0.161538 0.638462 0.361538 0.667649 29260.56 -0.172201 0.277992 0.447876 0.196911 0.142857 0.559846 0.440154 0.247104 0.131274 0.11583 6.089165 9.254826 NMV_0935 2191897 fCDS -1 933866 934780 915 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 11:51:37 no Belongs to the IS5 family. 2 vladimir 0.292712 0.2927 0.227001 0.187575 0.519713 0.480287 0.297491 0.268817 0.283154 0.150538 0.551971 0.448029 0.365591 0.21147 0.182796 0.240143 0.394265 0.605735 0.215054 0.397849 0.215054 0.172043 0.612903 0.387097 0.626551 31908.105 -0.598201 0.280576 0.435252 0.205036 0.115108 0.467626 0.532374 0.302158 0.179856 0.122302 9.024559 9.478417 NMV_0936 2191898 fCDS -1 934781 934873 93 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 11:51:28 no Belongs to the IS5 family. 2 vladimir 0.27957 0.2796 0.193548 0.247312 0.473118 0.526882 0.322581 0.258065 0.225806 0.193548 0.483871 0.516129 0.322581 0.193548 0.096774 0.387097 0.290323 0.709677 0.193548 0.387097 0.258065 0.16129 0.645161 0.354839 0.713612 3506.995 0.096667 0.2 0.366667 0.233333 0.133333 0.533333 0.466667 0.233333 0.133333 0.1 6.749474 8.2 NMV_0937 2191899 CDS +3 934932 935342 411 validated/Curated partial truncated TonB-dependent siderophore receptor (C-terminal 15% of the protein) 5 : Unknown function u : unknown 7 : Outer membrane protein 2018-03-23 15:37:36 no 1 vladimir 0.27972 0.2634 0.251748 0.205128 0.515152 0.484848 0.342657 0.167832 0.286713 0.202797 0.454545 0.545455 0.328671 0.181818 0.258741 0.230769 0.440559 0.559441 0.167832 0.440559 0.20979 0.181818 0.65035 0.34965 0.573281 15826.925 -0.564789 0.338028 0.549296 0.15493 0.169014 0.521127 0.478873 0.190141 0.133803 0.056338 9.883003 9.802817 NMV_0938 2191900 CDS +2 935486 936544 1059 validated/Curated no dinB DNA polymerase IV (Pol IV) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:23:28 no Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Exhibits no 3'-5' exonuclease (proofreading) activity. 1 vladimir 0.221907 0.2899 0.280453 0.207743 0.570349 0.429651 0.209632 0.27762 0.334278 0.17847 0.611898 0.388102 0.288952 0.260623 0.15864 0.291785 0.419263 0.580737 0.167139 0.331445 0.348442 0.152975 0.679887 0.320113 0.633772 39640.435 -0.188352 0.269886 0.463068 0.232955 0.110795 0.568182 0.431818 0.264205 0.159091 0.105114 9.382591 9.551136 NMV_0939 2191901 CDS -3 936612 938627 2016 validated/Curated no rep ATP-dependent DNA helicase Rep 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.6.4.12 RXN0-4261 2018-01-22 16:53:29 no Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. 1 vladimir 0.291667 0.2773 0.247024 0.184028 0.524306 0.475694 0.285714 0.235119 0.345238 0.133929 0.580357 0.419643 0.369048 0.18006 0.177083 0.27381 0.357143 0.642857 0.220238 0.416667 0.21875 0.144345 0.635417 0.364583 0.689554 75637.39 -0.450522 0.260805 0.445604 0.219076 0.09538 0.515648 0.484352 0.281669 0.150522 0.131148 7.009026 9.5693 NMV_0940 2191902 CDS -2 938647 939411 765 validated/Curated no aroD 3-dehydroquinate dehydratase (3-dehydroquinase; type I DHQase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 4.2.1.10 3-DEHYDROQUINATE-DEHYDRATASE-RXN PWY-6163 2018-01-19 11:53:15 no Catalyses the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate: 3-dehydroquinate <=> 3-dehydroshikimate + H(2)O. 1 vladimir 0.202614 0.3098 0.291503 0.196078 0.601307 0.398693 0.215686 0.247059 0.4 0.137255 0.647059 0.352941 0.239216 0.25098 0.203922 0.305882 0.454902 0.545098 0.152941 0.431373 0.270588 0.145098 0.701961 0.298039 0.634171 27077.105 0.18189 0.350394 0.555118 0.244094 0.066929 0.594488 0.405512 0.232283 0.110236 0.122047 5.171227 9.385827 NMV_0941 2191903 CDS +2 939665 940711 1047 validated/Curated no recA RecA protein (recombinase A) 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2018-01-19 11:53:38 no 3100504 Multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response. 2 vladimir 0.280802 0.2999 0.25788 0.161414 0.557784 0.442216 0.280802 0.183381 0.418338 0.117479 0.601719 0.398281 0.329513 0.186246 0.197708 0.286533 0.383954 0.616046 0.232092 0.530086 0.157593 0.080229 0.687679 0.312321 0.692709 37625.255 -0.23592 0.304598 0.511494 0.235632 0.063218 0.543103 0.456897 0.278736 0.12931 0.149425 5.096565 9.295977 NMV_0942 2191904 CDS -3 942663 942998 336 validated/Curated no putative DNA-binding protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-19 11:56:18 no Belongs to the nucleoid-associated protein YbaB-like domain superfamily 2 vladimir 0.327381 0.2887 0.247024 0.136905 0.535714 0.464286 0.294643 0.1875 0.428571 0.089286 0.616071 0.383929 0.348214 0.223214 0.160714 0.267857 0.383929 0.616071 0.339286 0.455357 0.151786 0.053571 0.607143 0.392857 0.691773 11894.2 -0.318919 0.324324 0.459459 0.171171 0.045045 0.558559 0.441441 0.288288 0.135135 0.153153 5.184792 9.477477 NMV_0943 2191905 CDS -1 943079 945208 2130 validated/Curated no dnaZX DNA polymerase III tau/gamma subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:22:14 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 2 vladimir 0.269014 0.3408 0.242723 0.147418 0.583568 0.416432 0.225352 0.257746 0.401408 0.115493 0.659155 0.340845 0.342254 0.321127 0.119718 0.216901 0.440845 0.559155 0.239437 0.443662 0.207042 0.109859 0.650704 0.349296 0.699574 76315.42 -0.387165 0.331453 0.54866 0.177715 0.076164 0.541608 0.458392 0.244006 0.104372 0.139633 4.742912 9.71086 NMV_0944 2191906 CDS -3 945303 947279 1977 validated/Curated no mutL DNA mismatch repair protein MutL 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2625 2018-01-19 11:57:32 no Mismatch repair contributes to the overall fidelity of DNA replication. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. 2 vladimir 0.250379 0.3480 0.234699 0.16692 0.582701 0.417299 0.253414 0.274659 0.359636 0.112291 0.634294 0.365706 0.305008 0.264036 0.168437 0.262519 0.432473 0.567527 0.192716 0.505311 0.176024 0.125948 0.681335 0.318665 0.702861 71740.475 -0.303343 0.317629 0.525836 0.206687 0.088146 0.522796 0.477204 0.265957 0.142857 0.1231 6.13488 9.389058 NMV_0945 2191907 CDS +1 947422 947607 186 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:19:29 no 2 vladimir 0.349462 0.2366 0.22043 0.193548 0.456989 0.543011 0.193548 0.274194 0.322581 0.209677 0.596774 0.403226 0.532258 0.16129 0.096774 0.209677 0.258065 0.741936 0.322581 0.274194 0.241935 0.16129 0.516129 0.483871 0.643858 7465.01 -1.203279 0.131148 0.311475 0.163934 0.147541 0.442623 0.557377 0.344262 0.131148 0.213115 4.605553 10.819672 NMV_0946 2191908 CDS +2 947618 948286 669 validated/Curated no putative O-methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.- 2018-01-19 11:58:12 no Belongs to a family of O-methyltransferases that includes some enzymes that may be involved in antibiotic production. 1 vladimir 0.243647 0.2795 0.270553 0.206278 0.550075 0.449925 0.273543 0.26009 0.340807 0.125561 0.600897 0.399103 0.29148 0.242152 0.161435 0.304933 0.403587 0.596413 0.165919 0.336323 0.309417 0.188341 0.64574 0.35426 0.64004 24266.145 -0.013063 0.283784 0.509009 0.27027 0.081081 0.581081 0.418919 0.238739 0.135135 0.103604 7.222115 9.220721 NMV_0947 2191909 CDS +1 948286 949002 717 validated/Curated no conserved hypothetical TPR-containing lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-30 19:09:22 no Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 2 vladimir 0.269177 0.2985 0.252441 0.179916 0.550907 0.449093 0.271967 0.238494 0.32636 0.16318 0.564854 0.435146 0.313808 0.267782 0.205021 0.213389 0.472803 0.527197 0.221757 0.389121 0.225941 0.16318 0.615063 0.384937 0.612459 26164.715 -0.503782 0.340336 0.508403 0.180672 0.088235 0.516807 0.483193 0.260504 0.163866 0.096639 9.6101 9.315126 NMV_0948 2191910 CDS +3 949050 949535 486 validated/Curated no purE N5-carboxyaminoimidazole ribonucleotide mutase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 5.4.99.18 RXN0-743 PWY-6123 2018-01-19 12:02:10 no Catalyses the following reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. 2 vladimir 0.23251 0.2984 0.273663 0.195473 0.572016 0.427984 0.228395 0.203704 0.432099 0.135802 0.635802 0.364198 0.246914 0.283951 0.154321 0.314815 0.438272 0.561728 0.222222 0.407407 0.234568 0.135802 0.641975 0.358025 0.676715 17096.15 0.245342 0.335404 0.521739 0.229814 0.074534 0.645963 0.354037 0.192547 0.093168 0.099379 5.39222 9.590062 NMV_0949 2191911 CDS -1 949718 951172 1455 validated/Curated no putative lactate utilization protein B 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.7.35 : Lactate oxidation ; 2018-01-27 18:48:27 no Might be involved in L-lactate degradation and allowing cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate. 2 vladimir 0.268729 0.2914 0.254296 0.185567 0.545704 0.454296 0.303093 0.259794 0.309278 0.127835 0.569072 0.430928 0.305155 0.237113 0.185567 0.272165 0.42268 0.57732 0.197938 0.37732 0.268041 0.156701 0.645361 0.354639 0.765045 53921.255 -0.334091 0.299587 0.477273 0.208678 0.082645 0.522727 0.477273 0.262397 0.152893 0.109504 8.65403 9.770661 NMV_0950 2191912 CDS -2 951169 951870 702 validated/Curated no putative lactate utilization protein C 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 1.7.35 : Lactate oxidation ; 2018-01-27 18:48:45 no Might be involved in L-lactate degradation and allowing cells to grow with lactate as the sole carbon source. 2 vladimir 0.245014 0.2692 0.266382 0.219373 0.535613 0.464387 0.273504 0.200855 0.363248 0.162393 0.564103 0.435897 0.294872 0.252137 0.166667 0.286325 0.418803 0.581197 0.166667 0.354701 0.269231 0.209402 0.623932 0.376068 0.764617 25896.63 -0.138627 0.296137 0.48927 0.206009 0.11588 0.570815 0.429185 0.257511 0.120172 0.137339 5.115685 9.506438 NMV_0951 2191913 CDS -3 951867 952670 804 validated/Curated no putative lactate utilization protein A 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 1.7.35 : Lactate oxidation ; 2020-02-19 11:26:22 no Might be involved in L-lactate degradation and allowing cells to grow with lactate as the sole carbon source. 1 vladimir 0.242308 0.2974 0.255128 0.205128 0.552564 0.447436 0.269231 0.203846 0.365385 0.161538 0.569231 0.430769 0.284615 0.234615 0.203846 0.276923 0.438462 0.561538 0.173077 0.453846 0.196154 0.176923 0.65 0.35 0.721059 28251.29 -0.1139 0.328185 0.525097 0.181467 0.11583 0.586873 0.413127 0.254826 0.127413 0.127413 5.448509 9.733591 NMV_0953 2191915 CDS +1 952828 954336 1509 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 12:05:44 no Belongs to the major facilitator superfamily of transport proteins. 1 vladimir 0.175551 0.2950 0.250888 0.278607 0.545842 0.454158 0.238806 0.275053 0.270789 0.215352 0.545842 0.454158 0.162047 0.277185 0.159915 0.400853 0.4371 0.5629 0.1258 0.332623 0.321962 0.219616 0.654584 0.345416 0.632218 50473.255 0.750855 0.326923 0.49359 0.305556 0.108974 0.692308 0.307692 0.117521 0.07906 0.038462 9.784309 8.113248 NMV_0954 2191916 CDS +1 954397 955974 1578 validated/Curated no putative cardiolipin synthase 3 : Putative function from multiple computational evidences e : enzyme 7 : Outer membrane protein 1.6.1 : Phospholipid ; 2.7.8.- CARDIOLIPSYN-RXN$RXN-8141 PWY-5269$PWY-5668 2018-01-29 22:16:35 no Catalyses the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE). 2 vladimir 0.252783 0.3608 0.212836 0.173543 0.573674 0.426326 0.251473 0.304519 0.302554 0.141454 0.607073 0.392927 0.312377 0.229862 0.180747 0.277014 0.410609 0.589391 0.194499 0.548134 0.155206 0.102161 0.70334 0.29666 0.612688 57533.495 -0.37874 0.265748 0.484252 0.242126 0.108268 0.509843 0.490157 0.285433 0.165354 0.120079 9.04731 9.204724 NMV_0955 2191917 CDS +1 956182 956715 534 validated/Curated no putative endopeptidase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 3.4.24.11-RXN 2018-01-30 19:11:11 no Contains a E. coli NLPC/Listeria P60 domain. 1 vladimir 0.2603 0.3783 0.202247 0.159176 0.580524 0.419476 0.314607 0.275281 0.264045 0.146067 0.539326 0.460674 0.269663 0.241573 0.230337 0.258427 0.47191 0.52809 0.196629 0.617977 0.11236 0.073034 0.730337 0.269663 0.639874 19393.57 -0.250847 0.361582 0.508475 0.180791 0.135593 0.542373 0.457627 0.220339 0.163842 0.056497 9.888023 8.711864 NMV_0956 2191918 CDS -2 956758 958059 1302 validated/Curated no aroA 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 2.5.1.19 2.5.1.19-RXN PWY-6163 2018-01-19 12:10:31 no Catalyses the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate, the last common precursor of all three aromatic amino acids: phosphoenolpyruvate + 3-phosphoshikimate <=> phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. 2 vladimir 0.22043 0.3226 0.248848 0.208141 0.571429 0.428571 0.232719 0.237327 0.384793 0.145161 0.62212 0.37788 0.274194 0.276498 0.152074 0.297235 0.428571 0.571429 0.154378 0.453917 0.209677 0.182028 0.663594 0.336406 0.696324 46994.03 -0.008314 0.314088 0.533487 0.240185 0.094688 0.577367 0.422633 0.256351 0.12933 0.127021 5.557564 9.371824 NMV_0957 2191919 CDS +3 958455 958931 477 validated/Curated no greA transcription elongation factor GreA (transcript cleavage factor GreA) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2020-04-22 13:04:52 no Is necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. Arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked DNA/RNA/polymerase ternary complexes. Cleavage of the nascent transcript by cleavage factors, such as GreA, allows the resumption of elongation from the new 3' terminus. 1 vladimir 0.287212 0.2746 0.268344 0.169811 0.542977 0.457023 0.238994 0.201258 0.446541 0.113208 0.647799 0.352201 0.377358 0.207547 0.144654 0.27044 0.352201 0.647799 0.245283 0.415094 0.213836 0.125786 0.628931 0.371069 0.745468 17502.055 -0.363924 0.265823 0.424051 0.253165 0.075949 0.512658 0.487342 0.335443 0.139241 0.196203 4.75808 9.746835 NMV_0958 2191920 CDS +1 960676 961854 1179 validated/Curated no porA major outer-membrane protein P.IA (protein IA; PIA; porin) 1c : Function from experimental evidences in the studied genus t : transporter 7 : Outer membrane protein 2018-01-19 12:11:23 no Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity. 1 vladimir 0.246819 0.2604 0.263783 0.229008 0.524173 0.475827 0.267176 0.165394 0.391858 0.175573 0.557252 0.442748 0.330789 0.231552 0.203562 0.234097 0.435115 0.564885 0.142494 0.384224 0.195929 0.277354 0.580153 0.419847 0.72074 42208.155 -0.415051 0.34949 0.568878 0.178571 0.114796 0.533163 0.466837 0.229592 0.125 0.104592 8.458138 9.096939 NMV_0959 2191921 CDS -1 962663 964459 1797 validated/Curated no putative Xaa-Pro aminopeptidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.4.11.9 3.4.11.9-RXN 2018-01-23 11:18:42 no Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. 2 vladimir 0.220367 0.3600 0.254869 0.164719 0.614914 0.385086 0.238731 0.250417 0.375626 0.135225 0.626043 0.373957 0.265442 0.282137 0.183639 0.268781 0.465776 0.534224 0.156928 0.547579 0.205342 0.09015 0.752922 0.247078 0.741238 64817.165 -0.085284 0.33612 0.545151 0.220736 0.09699 0.576923 0.423077 0.227425 0.11204 0.115385 5.422234 9.473244 NMV_0960 2191922 CDS +3 964917 966170 1254 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 12:12:37 no Belongs to the NRAMP family of Mn2+ and Fe2+ transporters. 1 vladimir 0.195375 0.2536 0.277512 0.273525 0.5311 0.4689 0.282297 0.15311 0.349282 0.215311 0.502392 0.497608 0.188995 0.258373 0.177033 0.375598 0.435407 0.564593 0.114833 0.349282 0.30622 0.229665 0.655502 0.344498 0.716991 45027.49 0.735252 0.347722 0.501199 0.275779 0.129496 0.707434 0.292566 0.129496 0.079137 0.05036 9.285713 8.800959 NMV_0961 2191923 CDS +1 966325 967836 1512 validated/Curated no lysS lysine-tRNA ligase (lysyl-tRNA synthetase; LysRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.6 LYSINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:48:17 no Catalyses the attachment of lysine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.261243 0.3029 0.25 0.185847 0.55291 0.44709 0.255952 0.253968 0.339286 0.150794 0.593254 0.406746 0.363095 0.188492 0.166667 0.281746 0.355159 0.644841 0.164683 0.46627 0.244048 0.125 0.710317 0.289683 0.818775 57197.61 -0.524652 0.228628 0.451292 0.208748 0.107356 0.516899 0.483101 0.292247 0.141153 0.151093 5.295555 9.819085 NMV_0962 2191924 CDS -2 968113 969120 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 12:12:55 no Belongs to the IS5 family. 2 vladimir 0.282738 0.2976 0.225198 0.194444 0.522817 0.477183 0.279762 0.28869 0.270833 0.160714 0.559524 0.440476 0.372024 0.199405 0.178571 0.25 0.377976 0.622024 0.196429 0.404762 0.22619 0.172619 0.630952 0.369048 0.667949 38416.52 -0.522985 0.268657 0.423881 0.20597 0.122388 0.492537 0.507463 0.286567 0.176119 0.110448 9.080742 9.244776 NMV_0964 2191926 CDS -2 969403 970764 1362 validated/Curated partial tpsS11 putative TpsS11 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-19 12:13:09 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.362087 0.2535 0.232162 0.15229 0.485623 0.514377 0.361022 0.15655 0.386581 0.095847 0.543131 0.456869 0.373802 0.252396 0.204473 0.169329 0.456869 0.543131 0.351438 0.351438 0.105431 0.191693 0.456869 0.543131 0.619704 32574.975 -0.648718 0.423077 0.599359 0.144231 0.073718 0.442308 0.557692 0.233974 0.121795 0.112179 5.915382 8.570513 NMV_0965 2191927 CDS -2 970801 971187 387 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:38:28 no 3 vladimir 0.369509 0.1214 0.178295 0.330749 0.299742 0.700258 0.271318 0.170543 0.263566 0.294574 0.434109 0.565891 0.395349 0.147287 0.131783 0.325581 0.27907 0.72093 0.44186 0.046512 0.139535 0.372093 0.186047 0.813953 0.481092 15450.265 -0.371875 0.140625 0.351562 0.234375 0.15625 0.5625 0.4375 0.296875 0.109375 0.1875 4.444588 9.648438 NMV_0967 2191929 CDS -1 971360 972325 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 12:13:28 no Belongs to the IS30 family. 2 vladimir 0.321946 0.3075 0.207039 0.163561 0.514493 0.485507 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.378882 0.170807 0.229814 0.220497 0.400621 0.599379 0.242236 0.456522 0.177019 0.124224 0.63354 0.36646 0.55966 38077.21 -0.903115 0.249221 0.389408 0.196262 0.130841 0.417445 0.582555 0.330218 0.239875 0.090343 10.186134 9.775701 NMV_0969 2191931 CDS +3 972663 973775 1113 validated/Curated frameshift ISNme1 transposase (contains a 35 aa insertion) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-19 12:13:40 no Belongs to the IS5 family. 2 vladimir 0.289308 0.2947 0.230907 0.185085 0.525606 0.474394 0.283019 0.285714 0.272237 0.15903 0.557952 0.442049 0.363881 0.210243 0.183288 0.242588 0.393531 0.606469 0.221024 0.38814 0.237197 0.153639 0.625337 0.374663 0.620677 42492.965 -0.590541 0.27027 0.432432 0.197297 0.118919 0.486486 0.513514 0.283784 0.175676 0.108108 9.357597 9.378378 NMV_0970 2191932 CDS -2 973984 974214 231 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:15:07 no 1 vladimir 0.233766 0.2511 0.264069 0.251082 0.515152 0.484848 0.181818 0.181818 0.324675 0.311688 0.506494 0.493506 0.324675 0.207792 0.220779 0.246753 0.428571 0.571429 0.194805 0.363636 0.246753 0.194805 0.61039 0.38961 0.629213 8767.425 -0.406579 0.276316 0.526316 0.210526 0.131579 0.526316 0.473684 0.223684 0.078947 0.144737 4.40966 10.013158 NMV_0971 2191933 CDS -1 974315 975325 1011 validated/Curated no putative doxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 12:15:27 no 2 vladimir 0.237389 0.2948 0.263106 0.204748 0.557864 0.442137 0.228487 0.225519 0.35905 0.186944 0.58457 0.41543 0.317507 0.222552 0.175074 0.284866 0.397626 0.602374 0.166172 0.436202 0.255193 0.142433 0.691395 0.308605 0.729595 37652.235 -0.286607 0.279762 0.497024 0.202381 0.142857 0.547619 0.452381 0.276786 0.145833 0.130952 6.020805 9.229167 NMV_0972 2191934 CDS -2 975631 977004 1374 validated/Curated no putative ATP-dependent RNA helicase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-19 12:15:50 no Belongs to the DEAD/DEAH box family of helicases that are involved in unwinding nucleic acids. 2 vladimir 0.261281 0.3326 0.243814 0.1623 0.576419 0.423581 0.277293 0.281659 0.336245 0.104803 0.617904 0.382096 0.312227 0.242358 0.172489 0.272926 0.414847 0.585153 0.194323 0.473799 0.222707 0.10917 0.696507 0.303493 0.670015 51049.56 -0.412035 0.282276 0.483589 0.214442 0.067834 0.503282 0.496718 0.277899 0.159737 0.118162 9.309959 9.862144 NMV_0973 2191935 CDS +1 977359 978369 1011 validated/Curated no dusB tRNA-dihydrouridine synthase B 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.3.1.- RXN0-1281 2018-01-19 12:16:54 no Catalyses the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. 2 vladimir 0.232443 0.3017 0.274975 0.1909 0.576657 0.423343 0.252226 0.231454 0.388724 0.127596 0.620178 0.379822 0.278932 0.237389 0.225519 0.25816 0.462908 0.537092 0.166172 0.436202 0.210682 0.186944 0.646884 0.353116 0.692502 36832.835 -0.149107 0.321429 0.52381 0.202381 0.10119 0.604167 0.395833 0.247024 0.142857 0.104167 8.394798 10.220238 NMV_0974 2191936 CDS +3 978399 978638 240 validated/Curated no fis DNA-binding protein Fis 2a : Function from experimental evidences in other organisms r : regulator 2 : Cytoplasmic 3.1.2 : Transcriptional level ; 2020-02-20 14:13:27 no 16963779 Activates transcription of ribosomal RNA, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT-rich sites, approximately half its binding sites are in non-coding DNA. 2 vladimir 0.2875 0.2417 0.229167 0.241667 0.470833 0.529167 0.2625 0.275 0.25 0.2125 0.525 0.475 0.3625 0.1375 0.175 0.325 0.3125 0.6875 0.2375 0.3125 0.2625 0.1875 0.575 0.425 0.746487 8937.09 -0.234177 0.21519 0.443038 0.265823 0.075949 0.544304 0.455696 0.227848 0.139241 0.088608 7.878899 9.848101 NMV_0975 2191937 CDS +2 978641 979177 537 validated/Curated no ruvC crossover junction endodeoxyribonuclease RuvC (Holliday junction nuclease RuvC; Holliday junction resolvase RuvC) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2.1.4 : DNA repair ; 3.1.22.4 3.1.22.4-RXN 2020-02-21 17:03:06 no Nuclease that resolves Holliday junction intermediates in genetic recombination. 1 vladimir 0.191806 0.2775 0.337058 0.193669 0.614525 0.385475 0.206704 0.240223 0.446927 0.106145 0.687151 0.312849 0.256983 0.26257 0.173184 0.307263 0.435754 0.564246 0.111732 0.329609 0.391061 0.167598 0.72067 0.27933 0.559787 18617.805 0.196629 0.337079 0.578652 0.258427 0.073034 0.629213 0.370787 0.202247 0.140449 0.061798 9.999428 9.404494 NMV_0976 2191938 CDS +1 979216 980097 882 validated/Curated no lpxL lipid A biosynthesis lauroyltransferase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 6 : Inner membrane-associated 1.6.3 : Lipopolysaccharide ; 2.3.1.241 LAUROYLACYLTRAN-RXN KDO-LIPASYN-PWY$KDO-NAGLIPASYN-PWY 2020-04-20 19:57:56 no Catalyses the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo2-lipid IV(A) to form Kdo2-(lauroyl)-lipid IV(A). Has 10 fold selectivity for lauroyl-ACP over myristoyl-ACP. 1 vladimir 0.242529 0.2517 0.250575 0.255172 0.502299 0.497701 0.234483 0.272414 0.293103 0.2 0.565517 0.434483 0.337931 0.186207 0.155172 0.32069 0.341379 0.658621 0.155172 0.296552 0.303448 0.244828 0.6 0.4 0.630038 33938.23 -0.250865 0.200692 0.391003 0.224913 0.176471 0.574394 0.425606 0.287197 0.179931 0.107266 9.533516 9.366782 NMV_0979 2191941 CDS +1 980848 981642 795 validated/Curated no putative ribonuclease H-like protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 12:20:59 no Contains a ribonuclease H fold found in various prokaryotic 3'-5' exonucleases. 1 vladimir 0.241509 0.2352 0.289308 0.233962 0.524528 0.475472 0.233962 0.226415 0.34717 0.192453 0.573585 0.426415 0.358491 0.154717 0.203774 0.283019 0.358491 0.641509 0.132075 0.324528 0.316981 0.226415 0.641509 0.358491 0.674215 30545.455 -0.401894 0.238636 0.458333 0.19697 0.159091 0.55303 0.44697 0.291667 0.143939 0.147727 5.342766 10.015152 NMV_0980 2191942 CDS +2 981854 984457 2604 validated/Curated no pepN aminopeptidase N (alpha-aminoacylpeptide hydrolase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.2.3 : Proteins/peptides/glycopeptides ; 3.4.11.2 3.4.11.2-RXN$RXN0-5195 2018-01-19 12:22:07 no Catalyses the release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. 2 vladimir 0.235791 0.2984 0.275346 0.190476 0.573733 0.426267 0.236175 0.226959 0.373272 0.163594 0.60023 0.39977 0.334101 0.220046 0.163594 0.282258 0.383641 0.616359 0.137097 0.448157 0.289171 0.125576 0.737327 0.262673 0.71693 97421.65 -0.326182 0.269896 0.49827 0.209919 0.117647 0.536332 0.463668 0.276817 0.133795 0.143022 5.293633 9.673587 NMV_0981 2191943 CDS -2 984799 987837 3039 validated/Curated no FrpA/C protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 10 : Secreted 2018-01-19 12:22:21 no Is homologous to the iron-regulated FrpA/C proteins, which are related to the RTX family of exoproteins. 1 vladimir 0.285949 0.2251 0.248437 0.24054 0.473511 0.526489 0.269497 0.146101 0.41461 0.169793 0.560711 0.439289 0.386969 0.202369 0.179664 0.230997 0.382034 0.617966 0.201382 0.326752 0.151037 0.320829 0.477789 0.522211 0.659103 108586.265 -0.511265 0.341897 0.588933 0.182806 0.107708 0.51087 0.48913 0.238142 0.089921 0.148221 4.352623 9.392292 NMV_0982 2191944 CDS -2 987925 989154 1230 validated/Curated partial putative FrpA/FrpC cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-19 12:22:34 no Is likely to be a non-expressed (silent) variable FrpC/A minicassette. C-terminus shows homology to FrpC/A whereas N-terminus is divergent. Is expected to allow antigenic variation of FrpC/A upon recombination at the frpC/A gene. 3 vladimir 0.296748 0.2163 0.231707 0.255285 0.447967 0.552033 0.3 0.136585 0.353659 0.209756 0.490244 0.509756 0.336585 0.217073 0.192683 0.253659 0.409756 0.590244 0.253659 0.295122 0.14878 0.302439 0.443902 0.556098 0.577831 44308.1 -0.307579 0.342298 0.557457 0.200489 0.110024 0.525672 0.474328 0.212714 0.09291 0.119804 4.741737 8.91687 NMV_0983 2191945 CDS -1 989141 989869 729 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-08 17:12:16 no 3 vladimir 0.363512 0.0878 0.139918 0.408779 0.227709 0.772291 0.378601 0.090535 0.218107 0.312757 0.308642 0.691358 0.366255 0.106996 0.090535 0.436214 0.197531 0.802469 0.345679 0.065844 0.111111 0.477366 0.176955 0.823045 0.459293 28655.845 0.390909 0.144628 0.376033 0.322314 0.202479 0.615702 0.384298 0.214876 0.140496 0.07438 9.277702 8.38843 NMV_0984 2191946 CDS -3 989904 990095 192 validated/Curated no FrpA/C-like protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 1 : Unknown 2018-01-19 12:22:55 no Is homologous to a internal part of the iron-regulated FrpA/C proteins, which are related to the RTX family of exoproteins. 3 vladimir 0.317708 0.2188 0.234375 0.229167 0.453125 0.546875 0.359375 0.140625 0.328125 0.171875 0.46875 0.53125 0.328125 0.203125 0.21875 0.25 0.421875 0.578125 0.265625 0.3125 0.15625 0.265625 0.46875 0.53125 0.498126 6780.4 -0.363492 0.365079 0.571429 0.174603 0.095238 0.507937 0.492063 0.269841 0.142857 0.126984 6.045799 8.793651 NMV_0985 2191947 CDS -2 990136 990570 435 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-08 17:11:53 no 3 vladimir 0.314943 0.0920 0.188506 0.404598 0.28046 0.71954 0.344828 0.089655 0.2 0.365517 0.289655 0.710345 0.268966 0.117241 0.172414 0.441379 0.289655 0.710345 0.331034 0.068966 0.193103 0.406897 0.262069 0.737931 0.491195 17053.715 0.572917 0.201389 0.361111 0.305556 0.180556 0.638889 0.361111 0.173611 0.104167 0.069444 8.933556 8.395833 NMV_0987 2191949 CDS +1 990907 991446 540 validated/Curated partial truncated IS1016 group transposase (N-terminal 82% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-08 17:11:43 no 1 vladimir 0.274074 0.2259 0.248148 0.251852 0.474074 0.525926 0.311111 0.188889 0.327778 0.172222 0.516667 0.483333 0.338889 0.15 0.2 0.311111 0.35 0.65 0.172222 0.338889 0.216667 0.272222 0.555556 0.444444 0.622018 20374.86 -0.273184 0.24581 0.458101 0.251397 0.122905 0.519553 0.480447 0.312849 0.217877 0.094972 10.071419 9.139665 NMNmiscRNA0157 54919374 misc_RNA -1 991625 991965 341 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 11:52:55 25951061, 28334889 Originally found in strain MC58. vladimir NMV_0990 2191952 CDS +3 992259 994487 2229 validated/Curated no putative FrpA/C translocation ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 12:23:20 no Type I protein secretion is a system to export proteins, often proteases, across both inner and outer-membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus, the system's ATPase. Targeted proteins are not cleaved at the N terminus, but rather carry signals located toward the extreme C terminus to direct type I secretion. 1 vladimir 0.195603 0.2212 0.306415 0.276806 0.527591 0.472409 0.216689 0.223419 0.341857 0.218035 0.565276 0.434724 0.243607 0.234186 0.154778 0.367429 0.388964 0.611036 0.126514 0.205922 0.422611 0.244953 0.628533 0.371467 0.558453 82234.655 0.358356 0.284367 0.475741 0.297844 0.11186 0.610512 0.389488 0.19407 0.11186 0.08221 9.03492 8.966307 NMV_0992 2191954 fCDS +3 994710 995027 318 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 12:23:33 no Belongs to the IS5 family. 2 vladimir 0.254717 0.3208 0.194969 0.22956 0.515723 0.484277 0.245283 0.339623 0.226415 0.188679 0.566038 0.433962 0.330189 0.150943 0.179245 0.339623 0.330189 0.669811 0.188679 0.471698 0.179245 0.160377 0.650943 0.349057 0.672338 12565.06 -0.258095 0.171429 0.371429 0.247619 0.161905 0.533333 0.466667 0.27619 0.152381 0.12381 6.451042 9.142857 NMV_0993 2191955 fCDS +3 995154 995549 396 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-19 12:23:43 no Belongs to the IS5 family. 2 vladimir 0.260101 0.2677 0.267677 0.204545 0.535354 0.464646 0.25 0.25 0.295455 0.204545 0.545455 0.454545 0.348485 0.227273 0.189394 0.234848 0.416667 0.583333 0.181818 0.325758 0.318182 0.174242 0.643939 0.356061 0.602292 14812.45 -0.441221 0.312977 0.442748 0.198473 0.129771 0.51145 0.48855 0.290076 0.206107 0.083969 9.711998 9.70229 NMV_0995 2191957 CDS -3 996135 996695 561 validated/Curated no sodC superoxide dismutase [Cu-Zn] 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 5.6.2 : Detoxification (xenobiotic metabolism) ; 1.15.1.1 SUPEROX-DISMUT-RXN DETOX1-PWY 2018-01-19 12:24:12 no Prevents damage by oxygen-mediated free radicals, by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide. 3 vladimir 0.304813 0.2032 0.229947 0.262032 0.433155 0.566845 0.240642 0.219251 0.390374 0.149733 0.609626 0.390374 0.331551 0.235294 0.192513 0.240642 0.427807 0.572193 0.342246 0.15508 0.106952 0.395722 0.262032 0.737968 0.599692 19549.135 -0.341398 0.333333 0.586022 0.209677 0.107527 0.55914 0.44086 0.258065 0.150538 0.107527 6.13253 9.16129 NMV_0996 2191958 CDS -3 996930 997097 168 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 17:10:45 no 3 vladimir 0.380952 0.1310 0.25 0.238095 0.380952 0.619048 0.339286 0.214286 0.214286 0.232143 0.428571 0.571429 0.428571 0.035714 0.285714 0.25 0.321429 0.678571 0.375 0.142857 0.25 0.232143 0.392857 0.607143 0.561139 6468.24 -0.970909 0.2 0.327273 0.181818 0.109091 0.454545 0.545455 0.327273 0.236364 0.090909 9.833122 8.818182 NMV_0997 2191959 CDS -1 997112 998152 1041 validated/Curated no mutY adenine DNA glycosylase (A/G-specific adenine glycosylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.2.2.- RXN0-2661 2018-01-23 11:13:58 no Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP). 2 vladimir 0.241114 0.3045 0.253602 0.200768 0.558117 0.441883 0.236311 0.268012 0.293948 0.201729 0.56196 0.43804 0.299712 0.244957 0.190202 0.26513 0.435159 0.564842 0.18732 0.400576 0.276657 0.135447 0.677233 0.322767 0.698354 39194.825 -0.330347 0.277457 0.473988 0.202312 0.109827 0.560694 0.439306 0.248555 0.144509 0.104046 8.843193 9.728324 NMV_0998 2191960 fCDS +2 998315 998461 147 validated/Curated pseudo putative alcohol dehydrogenase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.1.- ALCOHOL-DEHYDROG-GENERIC-RXN$ALCOHOL-DEHYDROG-RXN$ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN$RXN-10781$RXN-11039$RXN-11332$RXN-11333$RXN-11335$RXN-12448 FERMENTATION-PWY 2018-01-27 18:54:05 no 1 vladimir 0.295082 0.2295 0.256831 0.218579 0.486339 0.513661 0.360656 0.196721 0.278689 0.163934 0.47541 0.52459 0.295082 0.229508 0.245902 0.229508 0.47541 0.52459 0.229508 0.262295 0.245902 0.262295 0.508197 0.491803 0.64518 6906.785 -0.741667 0.283333 0.483333 0.183333 0.083333 0.466667 0.533333 0.35 0.25 0.1 10.283333 9.666667 NMV_0999 2191961 fCDS +3 998460 999260 801 validated/Curated pseudo putative alcohol dehydrogenase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.1.- ALCOHOL-DEHYDROG-GENERIC-RXN$ALCOHOL-DEHYDROG-RXN$ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN$RXN-10781$RXN-11039$RXN-11332$RXN-11333$RXN-11335$RXN-12448 FERMENTATION-PWY 2018-01-27 18:54:01 no 2 vladimir 0.268293 0.2764 0.247154 0.20813 0.523577 0.476423 0.297561 0.156098 0.404878 0.141463 0.560976 0.439024 0.331707 0.234146 0.126829 0.307317 0.360976 0.639024 0.17561 0.439024 0.209756 0.17561 0.64878 0.35122 0.829481 22076.365 0.073039 0.29902 0.558824 0.254902 0.083333 0.573529 0.426471 0.235294 0.102941 0.132353 4.788414 9.289216 NMV_1000 2191962 CDS -3 999516 1000154 639 validated/Curated no eda KHG/KDPG aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase (2-keto-4-hydroxyglutarate aldolase; KHG-aldolase) and 2-dehydro-3-deoxy-phosphogluconate aldolase (phospho-2- dehydro-3-deoxygluconate aldolase; phospho-2-keto-3-deoxygluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG- aldolase)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.9 : Entner-Doudoroff pathway ; 4.1.2.14, 4.1.3.16 4OH2OXOGLUTARALDOL-RXN$KDPGALDOL-RXN$OXALODECARB-RXN ENTNER-DOUDOROFF-PWY$GLYCOLYSIS-E-D 2018-01-29 17:09:24 no Catalyses the following reactions: 2-dehydro-3-deoxy-D-gluconate 6-phosphate <=> pyruvate + D-glyceraldehyde 3-phosphate and 4-hydroxy-2-oxoglutarate <=> pyruvate + glyoxylate. 2 vladimir 0.215962 0.3646 0.248826 0.170579 0.613459 0.386541 0.253521 0.225352 0.422535 0.098592 0.647887 0.352113 0.230047 0.305164 0.164319 0.300469 0.469484 0.530516 0.164319 0.56338 0.159624 0.112676 0.723005 0.276995 0.755744 21893.565 0.303774 0.353774 0.59434 0.273585 0.056604 0.646226 0.353774 0.207547 0.103774 0.103774 5.574013 8.764151 NMV_1001 2191963 CDS -3 1000335 1002170 1836 validated/Curated no edd phosphogluconate dehydratase (6-phosphogluconate dehydratase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.9 : Entner-Doudoroff pathway ; 4.2.1.12 PGLUCONDEHYDRAT-RXN ENTNER-DOUDOROFF-PWY$GLYCOLYSIS-E-D 2018-01-29 17:09:29 no Catalyses the first step in the Entner-Doudoroff pathway: 6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. 2 vladimir 0.23366 0.3175 0.259804 0.188998 0.577342 0.422658 0.281046 0.220588 0.362745 0.135621 0.583333 0.416667 0.271242 0.227124 0.207516 0.294118 0.434641 0.56536 0.148693 0.504902 0.20915 0.137255 0.714052 0.285948 0.77554 66226.33 -0.137643 0.322422 0.515548 0.206219 0.09329 0.577741 0.422259 0.240589 0.13257 0.10802 6.698204 9.695581 NMV_1002 2191964 CDS +1 1002736 1004181 1446 validated/Curated no zwf glucose-6-phosphate 1-dehydrogenase (G6PD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.2 : Pentose phosphate shunt, oxidative branch ; 1.1.1.49 GLU6PDEHYDROG-RXN GLYCOLYSIS-E-D$OXIDATIVEPENT-PWY 2018-01-31 15:08:47 no Catalyses the first step in the pentose pathway: D-glucose 6-phosphate + NADP(+) <=> D-glucono-1,5-lactone 6-phosphate + NADPH. 1 vladimir 0.263485 0.2490 0.268326 0.219225 0.517289 0.482711 0.257261 0.192946 0.373444 0.176349 0.56639 0.43361 0.344398 0.211618 0.155602 0.288382 0.36722 0.63278 0.188797 0.342324 0.275934 0.192946 0.618257 0.381743 0.732997 54043.53 -0.26736 0.264033 0.476091 0.22869 0.106029 0.544699 0.455301 0.27027 0.133056 0.137214 5.486641 9.75052 NMV_1003 2191965 CDS +1 1004461 1005156 696 validated/Curated no pgl 6-phosphogluconolactonase (6PGL) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.2 : Pentose phosphate shunt, oxidative branch ; 3.1.1.31 6PGLUCONOLACT-RXN GLYCOLYSIS-E-D$OXIDATIVEPENT-PWY 2018-01-31 15:09:06 no Catalyses the second step in the pentose phosphate pathway: 6-phospho-D-glucono-1,5-lactone + H(2)O <=> 6-phospho-D-gluconate. 1 vladimir 0.247126 0.2428 0.293103 0.216954 0.53592 0.46408 0.211207 0.181034 0.443966 0.163793 0.625 0.375 0.340517 0.262931 0.125 0.271552 0.387931 0.612069 0.189655 0.284483 0.310345 0.215517 0.594828 0.405172 0.700923 24979.08 -0.12684 0.307359 0.554113 0.21645 0.121212 0.575758 0.424242 0.255411 0.121212 0.134199 5.090584 9.588745 NMV_1004 2191966 CDS +2 1005137 1006123 987 validated/Curated no glk glucokinase (glucose kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 2.7.1.2 GLUCOKIN-RXN ANAGLYCOLYSIS-PWY$GLUCOSE1PMETAB-PWY$GLYCOCAT-PWY 2018-01-31 15:04:37 no Catalyses the following reaction: ATP + D-glucose <=> ADP + D-glucose 6-phosphate. 1 vladimir 0.206687 0.2817 0.288754 0.222898 0.570415 0.429585 0.240122 0.200608 0.379939 0.179331 0.580547 0.419453 0.24924 0.279635 0.18845 0.282675 0.468085 0.531915 0.130699 0.364742 0.297872 0.206687 0.662614 0.337386 0.677543 35009.805 0.111585 0.362805 0.557927 0.219512 0.112805 0.618902 0.381098 0.192073 0.112805 0.079268 8.596031 9.192073 NMV_1005 2191967 CDS +3 1006173 1007021 849 validated/Curated no hexR HTH-type transcriptional repressor HexR (hex regulon repressor) 2b : Function from indirect experimental evidences (e.g. phenotypes) r : regulator 2 : Cytoplasmic 3.1.2 : Transcriptional level ; 2018-01-19 12:29:52 no Represses the expression of the hex regulon (zwf, eda, glp and gap). 1 vladimir 0.224971 0.2898 0.265018 0.220259 0.55477 0.44523 0.236749 0.201413 0.39576 0.166078 0.597173 0.402827 0.293286 0.243816 0.155477 0.30742 0.399293 0.600707 0.144876 0.424028 0.243816 0.187279 0.667845 0.332155 0.692416 30380.485 0.098582 0.329787 0.521277 0.255319 0.08156 0.556738 0.443262 0.244681 0.120567 0.124113 5.399696 8.875887 NMV_1006 2191968 CDS +3 1007142 1008788 1647 validated/Curated no pgi1 glucose-6-phosphate isomerase 1 (GPI 1; phosphoglucose isomerase 1; PGI 1; phosphohexose isomerase 1; PHI 1) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 5.3.1.9 PGLUCISOM-RXN$RXN-6182 ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-22 17:30:16 no Is a dimeric enzyme that catalyses the following reaction: D-glucose 6-phosphate <=> D-fructose 6-phosphate. 2 vladimir 0.257438 0.3090 0.244687 0.188828 0.553734 0.446266 0.282332 0.256831 0.31694 0.143898 0.57377 0.42623 0.331512 0.193078 0.17122 0.304189 0.364299 0.635701 0.15847 0.477231 0.245902 0.118397 0.723133 0.276867 0.737351 62034.265 -0.294891 0.255474 0.456204 0.220803 0.135036 0.534672 0.465328 0.255474 0.138686 0.116788 6.000832 9.55292 NMV_1007 2191969 CDS +1 1008931 1009353 423 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:38:54 no 1 vladimir 0.336957 0.2210 0.278986 0.163043 0.5 0.5 0.271739 0.217391 0.358696 0.152174 0.576087 0.423913 0.402174 0.233696 0.168478 0.195652 0.402174 0.597826 0.336957 0.211957 0.309783 0.141304 0.521739 0.478261 0.586195 20989.06 -0.959016 0.273224 0.398907 0.142077 0.076503 0.437158 0.562842 0.377049 0.20765 0.169399 8.902046 9.797814 NMV_1009 2191971 CDS -2 1009684 1009923 240 validated/Curated partial truncated IS630 family transposase (internal fragment corresponding to 25% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 13:53:16 no 1 vladimir 0.353535 0.2357 0.225589 0.185185 0.461279 0.538721 0.323232 0.242424 0.232323 0.20202 0.474747 0.525253 0.40404 0.191919 0.232323 0.171717 0.424242 0.575758 0.333333 0.272727 0.212121 0.181818 0.484848 0.515152 0.459994 11595.695 -1.137755 0.285714 0.418367 0.142857 0.153061 0.418367 0.581633 0.326531 0.234694 0.091837 9.99868 9.795918 NMV_1010 2191972 CDS -3 1009923 1010147 225 validated/Curated partial truncated IS630 family transposase (internal fragment corresponding to 25% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-06-12 13:53:30 no 3 vladimir 0.359848 0.2538 0.193182 0.193182 0.44697 0.55303 0.363636 0.295455 0.204545 0.136364 0.5 0.5 0.386364 0.25 0.159091 0.204545 0.409091 0.590909 0.329545 0.215909 0.215909 0.238636 0.431818 0.568182 0.454563 10000.32 -0.789655 0.275862 0.436782 0.183908 0.114943 0.471264 0.528736 0.298851 0.252874 0.045977 10.337593 9.034483 NMV_1011 2191973 CDS -3 1010397 1010801 405 validated/Curated partial truncated IS1016 group transposase (N-terminal third of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-08 17:07:28 no 3 vladimir 0.353086 0.1630 0.202469 0.281481 0.365432 0.634568 0.318519 0.2 0.266667 0.214815 0.466667 0.533333 0.392593 0.133333 0.185185 0.288889 0.318519 0.681481 0.348148 0.155556 0.155556 0.340741 0.311111 0.688889 0.485315 15795.495 -0.56194 0.216418 0.373134 0.216418 0.156716 0.477612 0.522388 0.30597 0.201493 0.104478 9.796913 9.335821 NMV_1012 2191974 CDS -3 1010958 1013708 2751 validated/Curated no gyrA DNA gyrase subunit A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.1.1.1 : DNA bending, supercoiling, inversion ; 5.6.2.2 5.99.1.3-RXN 2020-04-22 16:08:47 no DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV, which is the main enzyme that unlinks newly replicated chromosomes in E.coli. 2 vladimir 0.269357 0.2941 0.256997 0.179571 0.551072 0.448928 0.280262 0.219193 0.390403 0.110142 0.609597 0.390403 0.331516 0.195202 0.188659 0.284624 0.38386 0.61614 0.196292 0.46783 0.19193 0.143948 0.65976 0.34024 0.737923 101460.195 -0.364301 0.272926 0.489083 0.235808 0.075328 0.522926 0.477074 0.300218 0.144105 0.156114 5.283485 9.766376 NMV_1013 2191975 CDS -2 1013806 1014306 501 validated/Curated no hscB co-chaperone protein HscB homolog 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2018-01-19 12:32:18 no Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA. 2 vladimir 0.275449 0.3174 0.209581 0.197605 0.526946 0.473054 0.227545 0.245509 0.323353 0.203593 0.568862 0.431138 0.371257 0.269461 0.107784 0.251497 0.377245 0.622754 0.227545 0.437126 0.197605 0.137725 0.634731 0.365269 0.691543 19130.795 -0.606627 0.271084 0.433735 0.150602 0.114458 0.475904 0.524096 0.295181 0.13253 0.162651 4.916481 9.740964 NMV_1014 2191976 CDS +1 1014388 1014609 222 validated/Curated no putative alternative ribosome-rescue factor A 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-27 18:56:09 no Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system. 1 vladimir 0.324324 0.2027 0.279279 0.193694 0.481982 0.518018 0.337838 0.216216 0.27027 0.175676 0.486486 0.513514 0.364865 0.094595 0.324324 0.216216 0.418919 0.581081 0.27027 0.297297 0.243243 0.189189 0.540541 0.459459 0.483105 8550.59 -1.20137 0.232877 0.410959 0.150685 0.123288 0.424658 0.575342 0.424658 0.342466 0.082192 11.29174 9.082192 NMV_1015 2191977 CDS -1 1014569 1014889 321 validated/Curated no iscA iron-binding protein IscA 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-01-19 12:35:39 no Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. 1 vladimir 0.286604 0.2461 0.252336 0.214953 0.498442 0.501558 0.261682 0.149533 0.411215 0.17757 0.560748 0.439252 0.383178 0.140187 0.214953 0.261682 0.35514 0.64486 0.214953 0.448598 0.130841 0.205607 0.579439 0.420561 0.752145 11580.485 -0.366981 0.311321 0.528302 0.198113 0.122642 0.54717 0.45283 0.292453 0.132075 0.160377 4.902809 9.566038 NMV_1016 2191978 CDS -2 1014976 1015362 387 validated/Curated no iscU iron-sulfur cluster assembly scaffold protein IscU 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-01-19 12:37:48 no A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. 2 vladimir 0.299742 0.2713 0.263566 0.165375 0.534884 0.465116 0.302326 0.131783 0.426357 0.139535 0.55814 0.44186 0.372093 0.209302 0.170543 0.248062 0.379845 0.620155 0.224806 0.472868 0.193798 0.108527 0.666667 0.333333 0.821139 13946.155 -0.353906 0.304688 0.546875 0.210938 0.070312 0.523438 0.476562 0.3125 0.140625 0.171875 4.916054 9.492188 NMV_1017 2191979 CDS -3 1015428 1015556 129 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:39:24 no 2 vladimir 0.294574 0.2171 0.294574 0.193798 0.511628 0.488372 0.186047 0.093023 0.55814 0.162791 0.651163 0.348837 0.488372 0.069767 0.186047 0.255814 0.255814 0.744186 0.209302 0.488372 0.139535 0.162791 0.627907 0.372093 0.726151 4460.455 -0.635714 0.261905 0.666667 0.214286 0.02381 0.47619 0.52381 0.357143 0.02381 0.333333 3.266029 10.214286 NMV_1018 2191980 CDS -3 1015623 1016837 1215 validated/Curated no iscS cysteine desulfurase IscS 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.25 : Alanine biosynthesis III ; 2.8.1.7 RXN-12587$RXN-12588$RXN-9787$RXN0-308 PWY0-1021 2018-01-30 10:08:33 no Catalyses the following reaction: L-cysteine + acceptor <=> L-alanine + S-sulfanyl-acceptor. Is one of at least 6 enzymes characteristic of the IscSUA-HscAB-Fsx system of iron-sulphur cluster assembly. 2 vladimir 0.276543 0.3095 0.234568 0.179424 0.544033 0.455967 0.266667 0.192593 0.402469 0.138272 0.595062 0.404938 0.328395 0.214815 0.165432 0.291358 0.380247 0.619753 0.234568 0.520988 0.135802 0.108642 0.65679 0.34321 0.8196 44758.315 -0.209653 0.287129 0.485149 0.232673 0.09901 0.539604 0.460396 0.29703 0.148515 0.148515 5.573158 9.574257 NMV_1019 2191981 CDS -2 1016866 1017312 447 validated/Curated no iscR iron-sulphur cluster-assembly HTH-type transcriptional repressor IscR 2b : Function from indirect experimental evidences (e.g. phenotypes) r : regulator 2 : Cytoplasmic 2018-01-19 12:40:07 no Is an iron-sulphur binding transcription factor of the ISC iron-sulphur cluster assembly system. 2 vladimir 0.259508 0.3468 0.237136 0.1566 0.583893 0.416107 0.308725 0.255034 0.328859 0.107383 0.583893 0.416107 0.295302 0.214765 0.221477 0.268456 0.436242 0.563758 0.174497 0.57047 0.161074 0.09396 0.731544 0.268456 0.674206 15984.605 -0.110811 0.351351 0.513514 0.22973 0.081081 0.547297 0.452703 0.216216 0.135135 0.081081 8.914436 9.378378 NMV_1020 2191982 CDS +3 1017603 1018775 1173 validated/Curated no lldD L-lactate dehydrogenase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.-.- L-LACTDEHYDROGFMN-RXN PWY0-1317 2018-03-23 15:39:51 no Catalyses the conversion of L-lactate to pyruvate: (S)-lactate + an oxidized electron acceptor <=> pyruvate + a reduced electron acceptor. 1 vladimir 0.253197 0.2344 0.293265 0.219096 0.527707 0.472293 0.30179 0.163683 0.358056 0.176471 0.521739 0.478261 0.294118 0.225064 0.196931 0.283887 0.421995 0.578005 0.163683 0.314578 0.324808 0.196931 0.639386 0.360614 0.682529 43499.275 -0.277179 0.302564 0.492308 0.205128 0.087179 0.535897 0.464103 0.289744 0.151282 0.138462 7.114662 9.348718 NMV_1021 2191983 CDS -1 1018919 1021699 2781 validated/Curated no putative type III restriction-modification system enzyme Res 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.21.5 3.1.21.5-RXN 2018-01-19 12:43:18 no Belongs to the type III restriction-modification system Res protein family. Catalyses the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. 3 vladimir 0.350593 0.1755 0.20676 0.26717 0.382237 0.617763 0.323625 0.167206 0.295577 0.213592 0.462783 0.537217 0.430421 0.173679 0.111111 0.28479 0.28479 0.71521 0.297735 0.185545 0.213592 0.303128 0.399137 0.600863 0.662351 107218.085 -0.636069 0.211663 0.419006 0.194384 0.137149 0.464363 0.535637 0.302376 0.155508 0.146868 5.886223 8.975162 NMV_1022 2191984 fCDS -3 1021689 1023143 1455 validated/Curated pseudo putative type III restriction-modification system enzyme Mod (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-19 12:43:42 no Belongs to the N4/N6-methyltransferase family. Specifically methylates the amino group at the C-6 position of adenines in DNA. 3 vladimir 0.35147 0.1870 0.200125 0.261413 0.387117 0.612883 0.32833 0.159475 0.30394 0.208255 0.463415 0.536585 0.410882 0.183865 0.138837 0.266417 0.322702 0.677298 0.315197 0.217636 0.157598 0.309568 0.375235 0.624765 0.611379 60968.475 -0.540226 0.244361 0.445489 0.195489 0.12594 0.484962 0.515038 0.281955 0.140977 0.140977 5.681145 9.086466 NMV_1023 2191985 fCDS -2 1023142 1023645 504 validated/Curated pseudo putative type III restriction-modification system enzyme Mod (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-19 12:43:51 no Belongs to the N4/N6-methyltransferase family. Specifically methylates the amino group at the C-6 position of adenines in DNA. 1 vladimir 0.321705 0.2326 0.215116 0.23062 0.447674 0.552326 0.319767 0.197674 0.284884 0.197674 0.482558 0.517442 0.383721 0.19186 0.145349 0.27907 0.337209 0.662791 0.261628 0.30814 0.215116 0.215116 0.523256 0.476744 0.662278 19167.83 -0.466667 0.245614 0.491228 0.222222 0.099415 0.473684 0.526316 0.251462 0.122807 0.128655 5.35067 8.538012 NMV_1024 2191986 CDS -2 1023862 1024806 945 validated/Curated no truB tRNA pseudouridine synthase B (tRNA pseudouridine 55 synthase; Psi55 synthase; tRNA-uridine isomerase; tRNA pseudouridylate synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.25 RXN-11839 2018-01-19 12:44:36 no Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. 2 vladimir 0.248918 0.3203 0.238095 0.192641 0.558442 0.441558 0.246753 0.220779 0.366883 0.165584 0.587662 0.412338 0.285714 0.272727 0.175325 0.266234 0.448052 0.551948 0.214286 0.467532 0.172078 0.146104 0.63961 0.36039 0.702411 33576.28 -0.137785 0.34202 0.508143 0.218241 0.091205 0.550489 0.449511 0.267101 0.14658 0.120521 7.782448 9.478827 NMV_1025 2191987 CDS -3 1024818 1025189 372 validated/Curated no rbfA ribosome-binding factor A 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 6.6 : Ribosome ; 2018-01-30 15:21:13 no One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits, required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. 2 vladimir 0.287634 0.3038 0.239247 0.169355 0.543011 0.456989 0.241935 0.274194 0.370968 0.112903 0.645161 0.354839 0.370968 0.177419 0.169355 0.282258 0.346774 0.653226 0.25 0.459677 0.177419 0.112903 0.637097 0.362903 0.737174 14363.9 -0.639837 0.203252 0.390244 0.227642 0.097561 0.471545 0.528455 0.382114 0.203252 0.178862 6.496117 10.227642 NMV_1026 2191988 CDS +3 1025379 1026623 1245 validated/Curated no clpX ATP-dependent Clp protease ATP-binding subunit ClpX 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 3.4.21.92-RXN 2018-01-19 12:46:17 no Functions as an ATP-depedent molecular chaperone and is the regulatory subunit of the ClpXP protease, which is involved in DNA damage repair, stationary-phase gene expression and SsrA-mediated protein quality control. 1 vladimir 0.270683 0.2458 0.26747 0.216064 0.513253 0.486747 0.26988 0.180723 0.383133 0.166265 0.563855 0.436145 0.33494 0.20241 0.168675 0.293976 0.371084 0.628916 0.207229 0.354217 0.250602 0.187952 0.604819 0.395181 0.693998 45243.805 -0.235749 0.282609 0.492754 0.251208 0.065217 0.524155 0.475845 0.289855 0.137681 0.152174 5.234138 9.268116 NMV_1027 2191989 CDS -3 1026726 1027922 1197 validated/Curated no argD dapC acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT; succinyldiaminopimelate transferase; DapATase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 1.5.1.7 : Lysine, diaminopimelate ; 2.6.1.11, 2.6.1.17 ACETYLORNTRANSAM-RXN$SUCCINYLDIAMINOPIMTRANS-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$DAPLYSINESYN-PWY$GLUTORN-PWY 2018-01-27 19:00:29 no Catalyses the following reactions: N(2)-acetyl-L-ornithine + 2-oxoglutarate <=> N-acetyl-L-glutamate 5-semialdehyde + L-glutamat and N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate <=> N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate. 1 vladimir 0.218045 0.2723 0.294069 0.215539 0.566416 0.433584 0.22807 0.213033 0.383459 0.175439 0.596491 0.403509 0.270677 0.263158 0.192982 0.273183 0.45614 0.54386 0.155388 0.340852 0.305764 0.197995 0.646617 0.353383 0.648377 42694.995 -0.012312 0.354271 0.535176 0.20603 0.10804 0.600503 0.399497 0.21608 0.11809 0.09799 6.247139 9.660804 NMV_1028 2191990 CDS +1 1028326 1028826 501 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:03:42 no 2 vladimir 0.255489 0.3373 0.215569 0.191617 0.552894 0.447106 0.269461 0.299401 0.317365 0.113772 0.616766 0.383234 0.287425 0.251497 0.155689 0.305389 0.407186 0.592814 0.209581 0.461078 0.173653 0.155689 0.634731 0.365269 0.686683 18630.635 -0.186747 0.283133 0.487952 0.222892 0.10241 0.5 0.5 0.283133 0.162651 0.120482 7.243584 9.295181 NMV_1029 2191991 fCDS +1 1028911 1029150 240 validated/Curated pseudo hypothetical lipoprotein (pseudogene part 1) 5 : Unknown function u : unknown 11 : Membrane 2008-06-18 16:20:27 no 2 vladimir 0.323529 0.3170 0.222222 0.137255 0.539216 0.460784 0.303922 0.303922 0.333333 0.058824 0.637255 0.362745 0.411765 0.294118 0.078431 0.215686 0.372549 0.627451 0.254902 0.352941 0.254902 0.137255 0.607843 0.392157 0.550514 10994.92 -0.583168 0.29703 0.50495 0.178218 0.049505 0.485149 0.514851 0.227723 0.108911 0.118812 5.155205 9.237624 NMV_1029.1 2662684 fCDS +1 1029154 1029465 312 validated/Curated pseudo hypothetical lipoprotein (pseudogene part 2) 5 : Unknown function u : unknown 11 : Membrane 2008-06-18 16:20:40 vladimir NMV_1030 2191992 CDS -3 1029954 1031342 1389 validated/Curated no putative ATP-dependent RNA helicase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 12:49:20 no Belongs to the DEAD/DEAH box family of helicases that are involved in unwinding nucleic acids. 2 vladimir 0.268539 0.2829 0.272138 0.176386 0.555076 0.444924 0.285097 0.205184 0.37365 0.136069 0.578834 0.421166 0.323974 0.205184 0.218143 0.2527 0.423326 0.576674 0.196544 0.438445 0.224622 0.140389 0.663067 0.336933 0.830843 51333.855 -0.545887 0.296537 0.480519 0.190476 0.084416 0.519481 0.480519 0.32684 0.188312 0.138528 9.453728 9.448052 NMV_1031 2191993 CDS +3 1031670 1032617 948 validated/Curated no rlmK/L ribosomal RNA large subunit methyltransferase K/L 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-19 12:52:35 no Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. 2 vladimir 0.2723 0.2723 0.237559 0.21784 0.509859 0.490141 0.276056 0.202817 0.315493 0.205634 0.51831 0.48169 0.352113 0.185915 0.185915 0.276056 0.371831 0.628169 0.188732 0.428169 0.211268 0.171831 0.639437 0.360563 0.654756 40916.045 -0.493503 0.245763 0.451977 0.20339 0.144068 0.514124 0.485876 0.29661 0.172316 0.124294 9.274712 9.316384 NMV_1032 2191994 CDS -2 1032670 1033002 333 validated/Curated no trxA thioredoxin (TRX) 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.6.15.2 : Thioredoxin, glutaredoxin ; 2018-01-19 12:53:30 no Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyses dithiol-disulfide exchange reactions. 2 vladimir 0.237237 0.2853 0.258258 0.219219 0.543544 0.456456 0.279279 0.144144 0.423423 0.153153 0.567568 0.432432 0.252252 0.243243 0.162162 0.342342 0.405405 0.594595 0.18018 0.468468 0.189189 0.162162 0.657658 0.342342 0.85434 11830.255 0.344545 0.3 0.563636 0.263636 0.081818 0.627273 0.372727 0.236364 0.1 0.136364 4.699654 8.954545 NMV_1033 2191995 CDS +1 1033300 1033773 474 validated/Curated no drnN iron-sulfur cluster repair protein DnrN 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-01-19 12:54:02 no 18203837 Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. Required to repair damage caused by nitric oxide to FNR and NsrR transcription factors. 1 vladimir 0.244726 0.2574 0.278481 0.219409 0.535865 0.464135 0.221519 0.278481 0.373418 0.126582 0.651899 0.348101 0.348101 0.202532 0.126582 0.322785 0.329114 0.670886 0.164557 0.291139 0.335443 0.208861 0.626582 0.373418 0.670066 17949.88 -0.203185 0.22293 0.426752 0.210191 0.140127 0.566879 0.433121 0.292994 0.140127 0.152866 5.136192 10.401274 NMV_1034 2191996 CDS -2 1033843 1034634 792 validated/Curated no nadE NH(3)-dependent NAD(+) synthetase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 6.3.1.5 NAD-SYNTH-GLN-RXN$NAD-SYNTH-NH3-RXN PYRIDNUCSAL-PWY$PYRIDNUCSYN-PWY 2018-01-19 12:54:31 no Catalyses the last step in the biosynthesis of nicotinamide adenine dinucleotide (NAD): ATP + deamido-NAD(+) + NH(3) <=> AMP + diphosphate + NAD(+). 2 vladimir 0.238443 0.2981 0.282238 0.181265 0.580292 0.419708 0.240876 0.281022 0.361314 0.116788 0.642336 0.357664 0.284672 0.237226 0.208029 0.270073 0.445255 0.554745 0.189781 0.375912 0.277372 0.156934 0.653285 0.346715 0.57237 30392.43 -0.315751 0.304029 0.494505 0.208791 0.106227 0.553114 0.446886 0.252747 0.135531 0.117216 6.42498 10.014652 NMV_1035 2191997 CDS +2 1034807 1036216 1410 validated/Curated no xseA exodeoxyribonuclease VII large subunit (exonuclease VII large subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.11.6 3.1.11.6-RXN 2018-01-19 12:54:55 no Exonuclease VII is composed of two non-identical subunits: one large subunit and 4 small. It catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. 2 vladimir 0.236726 0.2950 0.264749 0.20354 0.559735 0.440265 0.205752 0.269911 0.362832 0.161504 0.632743 0.367257 0.307522 0.236726 0.185841 0.269911 0.422566 0.577434 0.196903 0.378319 0.245575 0.179204 0.623894 0.376106 0.701987 49968.11 -0.256541 0.305987 0.48337 0.228381 0.090909 0.521064 0.478936 0.268293 0.157428 0.110865 8.929176 9.432373 NMV_1036 2191998 CDS +3 1037145 1038686 1542 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 12:55:11 no Belongs to the major facilitator superfamily of transport proteins. 2 vladimir 0.196498 0.2964 0.27821 0.228923 0.574578 0.425422 0.243191 0.178988 0.371595 0.206226 0.550584 0.449416 0.184825 0.252918 0.202335 0.359922 0.455253 0.544747 0.161479 0.457198 0.2607 0.120623 0.717899 0.282101 0.680412 54370.5 0.65653 0.368421 0.54386 0.265107 0.134503 0.703704 0.296296 0.126706 0.079922 0.046784 9.189369 8.584795 NMV_1037 2191999 CDS -1 1038755 1039804 1050 validated/Curated no rluB ribosomal large subunit pseudouridine synthase B (rRNA-uridine isomerase B; rRNA pseudouridylate synthase B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.22 RXN-11836 2018-01-19 12:55:59 no Is responsible for the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA. 2 vladimir 0.274454 0.3333 0.255461 0.136752 0.588794 0.411206 0.273504 0.276353 0.353276 0.096866 0.62963 0.37037 0.321937 0.190883 0.239316 0.247863 0.430199 0.569801 0.22792 0.532764 0.173789 0.065527 0.706553 0.293447 0.755897 39511.835 -0.703143 0.26 0.462857 0.205714 0.065714 0.494286 0.505714 0.32 0.2 0.12 10.235374 9.685714 NMV_1038 2192000 CDS +3 1040028 1040660 633 validated/Curated no pdxH pyridoxine/pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase; PNPOx) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.6 : Pyridoxine (vitamin B6) ; 1.4.3.5 PMPOXI-RXN$PNPOXI-RXN PLPSAL-PWY$PYRIDOXSYN-PWY 2018-01-19 12:57:43 no Is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate by catalysing the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). 1 vladimir 0.202212 0.2243 0.350711 0.222749 0.575039 0.424961 0.189573 0.260664 0.369668 0.180095 0.630332 0.369668 0.308057 0.189573 0.241706 0.260664 0.43128 0.56872 0.109005 0.222749 0.440758 0.227488 0.663507 0.336493 0.590978 24200.475 -0.564762 0.228571 0.466667 0.204762 0.133333 0.538095 0.461905 0.314286 0.171429 0.142857 6.792412 10.166667 NMV_1039 2192001 CDS -1 1040789 1041799 1011 validated/Curated no putative iron/sulphur-binding oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-19 12:58:23 no Contains a 2Fe/2S-binding domain found in ferredoxins and various oxidoreductases. 2 vladimir 0.252226 0.3323 0.231454 0.183976 0.563798 0.436202 0.240356 0.264095 0.329377 0.166172 0.593472 0.406528 0.308605 0.243323 0.186944 0.261128 0.430267 0.569733 0.207715 0.489614 0.178042 0.124629 0.667656 0.332344 0.710594 36652.285 -0.267262 0.3125 0.520833 0.205357 0.098214 0.553571 0.446429 0.232143 0.127976 0.104167 6.548027 9.267857 NMV_1040 2192002 CDS -3 1041891 1043321 1431 validated/Curated no gatB aspartyl-tRNA(Asn) amidotransferase subunit B (Asp-ADT subunit B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.3.5.6 6.3.5.6-RXN PWY490-4 2018-01-18 18:10:56 no In N. meningitidis, the asparagine-tRNA ligase is missing. The GatABC system operates to convert misacylated Asp-tRNA(Asn), catalysed by the non-discriminating aspartate-tRNA(Asp/Asn) ligase, into Asn-tRNA(Asn). 2 vladimir 0.287212 0.2760 0.265549 0.171209 0.541579 0.458421 0.262055 0.174004 0.429769 0.134172 0.603774 0.396226 0.343816 0.245283 0.140461 0.27044 0.385744 0.614256 0.255765 0.408805 0.226415 0.109015 0.63522 0.36478 0.777982 51733.845 -0.25063 0.296218 0.508403 0.210084 0.073529 0.556723 0.443277 0.27521 0.128151 0.147059 5.127541 9.556723 NMV_1041 2192003 CDS -3 1043364 1044296 933 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 17:00:58 no 2 vladimir 0.27224 0.2840 0.235798 0.207931 0.519829 0.480171 0.244373 0.276527 0.292605 0.186495 0.569132 0.430868 0.340836 0.192926 0.186495 0.279743 0.379421 0.620579 0.231511 0.382637 0.228296 0.157556 0.610932 0.389068 0.661326 36249.535 -0.509355 0.241935 0.406452 0.187097 0.145161 0.525806 0.474194 0.3 0.190323 0.109677 9.700996 9.774194 NMV_1042 2192004 CDS -1 1044293 1045738 1446 validated/Curated no gatA aspartyl-tRNA(Asn) amidotransferase subunit A (Asp-ADT subunit A) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.3.5.6 6.3.5.6-RXN PWY490-4 2018-01-18 18:11:15 no In N. meningitidis, the asparagine-tRNA ligase is missing. The GatABC system operates to convert misacylated Asp-tRNA(Asn), catalysed by the non-discriminating aspartate-tRNA(Asp/Asn) ligase, into Asn-tRNA(Asn). 1 vladimir 0.236515 0.3368 0.240664 0.18603 0.577455 0.422545 0.240664 0.215768 0.379668 0.1639 0.595436 0.404564 0.286307 0.296681 0.176349 0.240664 0.473029 0.526971 0.182573 0.497925 0.165975 0.153527 0.6639 0.3361 0.723183 51231.85 -0.135759 0.376299 0.557173 0.191268 0.095634 0.588358 0.411642 0.199584 0.097713 0.101871 5.425865 9.372141 NMV_1043 2192005 CDS -2 1045801 1046091 291 validated/Curated no gatC aspartyl-tRNA(Asn) amidotransferase subunit C (Asp-ADT subunit C) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.3.5.6 6.3.5.6-RXN PWY490-4 2018-01-18 18:11:30 no In N. meningitidis, the asparagine-tRNA ligase is missing. The GatABC system operates to convert misacylated Asp-tRNA(Asn), catalysed by the non-discriminating aspartate-tRNA(Asp/Asn) ligase, into Asn-tRNA(Asn). 2 vladimir 0.312715 0.3093 0.230241 0.147766 0.539519 0.460481 0.237113 0.28866 0.402062 0.072165 0.690722 0.309278 0.381443 0.247423 0.082474 0.28866 0.329897 0.670103 0.319588 0.391753 0.206186 0.082474 0.597938 0.402062 0.73086 11000.075 -0.438542 0.21875 0.427083 0.239583 0.0625 0.479167 0.520833 0.34375 0.135417 0.208333 4.607796 10.572917 NMV_1044 2192006 CDS +1 1046242 1046895 654 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-19 12:58:59 no Belongs to a family of integral membrane proteins that includes the antibiotic resistance protein MarC. 1 vladimir 0.183486 0.2477 0.327217 0.24159 0.574924 0.425076 0.316514 0.174312 0.385321 0.123853 0.559633 0.440367 0.151376 0.256881 0.183486 0.408257 0.440367 0.559633 0.082569 0.311927 0.412844 0.192661 0.724771 0.275229 0.583047 22116.59 1.02212 0.368664 0.557604 0.35023 0.050691 0.723502 0.276498 0.105991 0.073733 0.032258 10.00338 8.43318 NMV_1045 2192007 CDS +2 1046900 1048243 1344 validated/Curated no putative aldehyde dehydrogenase-like protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.2.1.- 2018-01-19 12:59:45 no Aldehyde dehydrogenases are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes, using NADP as a cofactor. 1 vladimir 0.21131 0.2760 0.299107 0.213542 0.575149 0.424851 0.194196 0.212054 0.415179 0.178571 0.627232 0.372768 0.267857 0.256696 0.209821 0.265625 0.466518 0.533482 0.171875 0.359375 0.272321 0.196429 0.631696 0.368304 0.633295 49205.36 -0.112975 0.331096 0.521253 0.196868 0.114094 0.592841 0.407159 0.266219 0.14094 0.12528 6.420921 10.073826 NMV_1046 2192008 CDS -1 1048292 1048726 435 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 16:59:52 no 1 vladimir 0.331034 0.2851 0.229885 0.154023 0.514943 0.485057 0.337931 0.22069 0.317241 0.124138 0.537931 0.462069 0.42069 0.255172 0.137931 0.186207 0.393103 0.606897 0.234483 0.37931 0.234483 0.151724 0.613793 0.386207 0.598004 16131.445 -0.984028 0.270833 0.527778 0.145833 0.0625 0.4375 0.5625 0.298611 0.173611 0.125 9.392952 9.798611 NMV_1047 2192009 CDS -2 1049668 1050924 1257 validated/Curated no putative ribosomal RNA small subunit methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.- 2020-02-18 16:10:03 no 2 vladimir 0.265712 0.3158 0.237072 0.181384 0.552904 0.447096 0.24105 0.279236 0.350835 0.128878 0.630072 0.369928 0.336516 0.22673 0.169451 0.267303 0.396181 0.603819 0.21957 0.441527 0.190931 0.147971 0.632458 0.367542 0.719991 46571.575 -0.376794 0.277512 0.454545 0.227273 0.083732 0.519139 0.480861 0.299043 0.169856 0.129187 8.850136 9.239234 NMV_1048 2192010 CDS -2 1050961 1051812 852 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-21 12:19:40 no 2 vladimir 0.225659 0.3150 0.25315 0.206186 0.568156 0.431844 0.178694 0.312715 0.33677 0.171821 0.649485 0.350515 0.298969 0.243986 0.185567 0.271478 0.429553 0.570447 0.199313 0.388316 0.237113 0.175258 0.62543 0.37457 0.627335 32690.125 -0.243103 0.272414 0.455172 0.217241 0.131034 0.593103 0.406897 0.244828 0.124138 0.12069 5.609688 9.741379 NMV_1049 2192011 CDS -2 1051873 1052688 816 validated/Curated no putative tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.200 RXN-11866$RXN-11867 2018-01-19 13:02:55 no In E. coli TrmJ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine(32) in tRNA. 2 vladimir 0.251226 0.3346 0.227941 0.186275 0.5625 0.4375 0.308824 0.264706 0.308824 0.117647 0.573529 0.426471 0.286765 0.264706 0.154412 0.294118 0.419118 0.580882 0.158088 0.474265 0.220588 0.147059 0.694853 0.305147 0.731799 30017.18 -0.202583 0.302583 0.505535 0.206642 0.088561 0.520295 0.479705 0.236162 0.125461 0.110701 5.998802 9.797048 NMV_1050 2192012 CDS +1 1052932 1053717 786 validated/Curated no suhB inositol-1-monophosphatase (IMPase; inositol-1-phosphatase; I-1-Pase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.3.25 GLYCEROL-2-PHOSPHATASE-RXN$RXN0-5408 2018-01-19 13:03:19 no Catalyses the following reaction in the inositol phosphate second messenger signalling pathway: myo-inositol phosphate + H(2)O <=> myo-inositol + phosphate. 1 vladimir 0.239186 0.2684 0.25827 0.234097 0.526718 0.473282 0.248092 0.179389 0.400763 0.171756 0.580153 0.419847 0.301527 0.229008 0.175573 0.293893 0.40458 0.59542 0.167939 0.396947 0.198473 0.236641 0.59542 0.40458 0.79878 28467.4 -0.060536 0.310345 0.517241 0.218391 0.103448 0.586207 0.413793 0.260536 0.1341 0.126437 5.82502 9.48659 NMV_1051 2192013 fCDS +3 1053987 1054796 810 validated/Curated pseudo putative TonB-dependent receptor protein (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) rc : receptor 7 : Outer membrane protein 2018-03-23 15:40:13 no TonB interacts with outer-membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space in E. coli. In the absence of TonB these receptors bind their substrates but do not carry out active transport. 2 vladimir 0.290058 0.2632 0.250292 0.196491 0.51345 0.48655 0.322807 0.178947 0.333333 0.164912 0.512281 0.487719 0.336842 0.245614 0.182456 0.235088 0.42807 0.57193 0.210526 0.364912 0.235088 0.189474 0.6 0.4 0.692551 31576.185 -0.559155 0.316901 0.549296 0.169014 0.102113 0.496479 0.503521 0.228873 0.130282 0.098592 9.499123 9.588028 NMV_1052 2192014 fCDS +2 1054793 1055392 600 validated/Curated pseudo putative TonB-dependent receptor protein (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) rc : receptor 7 : Outer membrane protein 2018-03-23 15:40:27 no TonB interacts with outer-membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space in E. coli. In the absence of TonB these receptors bind their substrates but do not carry out active transport. 2 vladimir 0.271762 0.2505 0.239915 0.237792 0.490446 0.509554 0.280255 0.197452 0.286624 0.235669 0.484076 0.515924 0.350318 0.210191 0.171975 0.267516 0.382166 0.617834 0.184713 0.343949 0.261146 0.210191 0.605096 0.394904 0.718799 17816.565 -0.427564 0.269231 0.512821 0.205128 0.134615 0.532051 0.467949 0.198718 0.121795 0.076923 9.493782 9.615385 NMV_1053 2192015 CDS +2 1055516 1057066 1551 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 6 : Inner membrane-associated 2008-05-08 16:58:40 no 1 vladimir 0.29078 0.2186 0.253385 0.237266 0.471954 0.528046 0.307544 0.166344 0.348162 0.17795 0.514507 0.485493 0.357834 0.210832 0.141199 0.290135 0.352031 0.647969 0.206963 0.27853 0.270793 0.243714 0.549323 0.450677 0.671318 57040.555 -0.323643 0.281008 0.48062 0.218992 0.098837 0.517442 0.482558 0.263566 0.125969 0.137597 5.267143 8.792636 NMV_1054 2192016 CDS -2 1057426 1059210 1785 validated/Curated no putative pyruvate dehydrogenase E3 component (dihydrolipoyl dehydrogenase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.3.3 : Pyruvate dehydrogenase ; 1.8.1.4 1.8.1.4-RXN$DIHYDLIPOXN-RXN$RXN-7716$RXN-7719$RXN-8629$RXN0-1132 GLYCLEAV-PWY$PWY-5084$PYRUVDEHYD-PWY 2018-01-27 19:04:25 no Component of the pyruvate dehydrogenase (PDH) complex, that catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. E3 catalyses the following reaction: enzyme N(6)-(dihydrolipoyl)lysine + NAD(+) <=> enzyme N(6)-(lipoyl)lysine + NADH. 1 vladimir 0.241457 0.2840 0.281233 0.193277 0.565266 0.434734 0.247059 0.156303 0.482353 0.114286 0.638655 0.361345 0.292437 0.255462 0.173109 0.278992 0.428571 0.571429 0.184874 0.440336 0.188235 0.186555 0.628571 0.371429 0.835648 61897.145 0.043603 0.341751 0.587542 0.23569 0.06734 0.622896 0.377104 0.247475 0.116162 0.131313 5.106499 9.558923 NMV_1055 2192017 CDS -1 1059287 1060858 1572 validated/Curated no aceF pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide acetyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.3 : Pyruvate dehydrogenase ; 1.3.5 : Fermentation ; 1.3.6 : Aerobic respiration ; 2.3.1.12 PYRUVDEH-RXN$RXN-12508$RXN-12583$RXN0-1132$RXN0-1133$RXN0-1134 ANARESP1-PWY$PWY-5482$PYRUVDEHYD-PWY 2018-01-31 15:22:04 no Component of the pyruvate dehydrogenase (PDH) complex, that catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. E2 catalyses the following reaction: acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. 2 vladimir 0.246183 0.2837 0.263359 0.206743 0.547074 0.452926 0.244275 0.156489 0.473282 0.125954 0.629771 0.370229 0.270992 0.295802 0.139313 0.293893 0.435115 0.564885 0.223282 0.398855 0.177481 0.200382 0.576336 0.423664 0.848884 54208.11 0.142447 0.34608 0.596558 0.244742 0.055449 0.609943 0.390057 0.244742 0.118547 0.126195 5.360069 8.787763 NMV_1056 2192018 CDS -3 1061004 1063667 2664 validated/Curated no aceE pyruvate dehydrogenase E1 component 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.3 : Pyruvate dehydrogenase ; 1.3.5 : Fermentation ; 1.3.6 : Aerobic respiration ; 1.2.4.1 PYRUVDEH-RXN$RXN-12508$RXN-12583$RXN0-1132$RXN0-1133$RXN0-1134 ANARESP1-PWY$PWY-5482$PYRUVDEHYD-PWY 2018-01-31 15:22:28 no Component of the pyruvate dehydrogenase (PDH) complex, that catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. E1 catalyses the following reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). 2 vladimir 0.257508 0.2812 0.253378 0.207958 0.534535 0.465465 0.227477 0.219595 0.375 0.177928 0.594595 0.405405 0.349099 0.202703 0.188063 0.260135 0.390766 0.609234 0.195946 0.421171 0.197072 0.185811 0.618243 0.381757 0.84722 99456.35 -0.440361 0.276212 0.483653 0.19053 0.128523 0.553551 0.446449 0.271702 0.135287 0.136415 5.521461 9.777903 NMNmiscRNA0149 54905473 misc_RNA +1 1064029 1064150 122 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 10:45:31 28334889 Function unknown. vladimir NMV_1058 2192020 CDS +3 1064361 1066073 1713 validated/Curated no proS proline-tRNA ligase (prolyl-tRNA synthetase; ProRS; global RNA synthesis factor) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.15 PROLINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:49:16 no Catalyses the attachment of proline to its cognate transfer RNA molecule in a highly specific two-step reaction. 1 vladimir 0.248103 0.2744 0.276124 0.201401 0.550496 0.449504 0.236427 0.189142 0.423818 0.150613 0.61296 0.38704 0.322242 0.21366 0.175131 0.288967 0.388792 0.611208 0.185639 0.420315 0.229422 0.164623 0.649737 0.350263 0.776401 62932.055 -0.197895 0.285965 0.505263 0.221053 0.1 0.566667 0.433333 0.277193 0.129825 0.147368 5.135338 9.875439 NMV_1059 2192021 CDS +2 1066136 1066792 657 validated/Curated no putative hydrolase/isomerase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 14:25:38 no 1 vladimir 0.22831 0.1933 0.333333 0.245053 0.526636 0.473364 0.219178 0.136986 0.424658 0.219178 0.561644 0.438356 0.269406 0.187215 0.223744 0.319635 0.410959 0.589041 0.196347 0.255708 0.351598 0.196347 0.607306 0.392694 0.552015 23009.425 0.184862 0.334862 0.541284 0.261468 0.087156 0.62844 0.37156 0.229358 0.105505 0.123853 5.017311 9.055046 NMV_1060 2192022 CDS -1 1066802 1067257 456 validated/Curated no putative pre-16S rRNA nuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.-.- 2018-01-22 20:21:55 no 25545592 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. 1 vladimir 0.234649 0.2675 0.296053 0.201754 0.563596 0.436404 0.190789 0.243421 0.394737 0.171053 0.638158 0.361842 0.302632 0.210526 0.210526 0.276316 0.421053 0.578947 0.210526 0.348684 0.282895 0.157895 0.631579 0.368421 0.600989 16655.22 -0.286755 0.311258 0.483444 0.192053 0.145695 0.562914 0.437086 0.278146 0.15894 0.119205 6.720741 9.377483 NMV_1061 2192023 CDS -3 1067250 1067798 549 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-08 16:57:03 no 2 vladimir 0.24408 0.3024 0.242259 0.211293 0.544627 0.455373 0.26776 0.20765 0.36612 0.15847 0.57377 0.42623 0.295082 0.234973 0.163934 0.306011 0.398907 0.601093 0.169399 0.464481 0.196721 0.169399 0.661202 0.338798 0.664243 19849.725 -0.008791 0.302198 0.532967 0.21978 0.120879 0.587912 0.412088 0.225275 0.104396 0.120879 4.956749 9.21978 NMV_1062 2192024 CDS -2 1067800 1068360 561 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 14:26:52 no Similar to CreA of E. coli, a protein of unknown function. 1 vladimir 0.26025 0.2620 0.258467 0.219251 0.520499 0.479501 0.272727 0.15508 0.368984 0.203209 0.524064 0.475936 0.304813 0.240642 0.192513 0.262032 0.433155 0.566845 0.203209 0.390374 0.213904 0.192513 0.604278 0.395722 0.67255 20019.895 -0.206989 0.349462 0.569892 0.198925 0.086022 0.537634 0.462366 0.247312 0.129032 0.11828 7.749763 8.876344 NMV_1063 2192025 CDS +1 1068688 1070493 1806 validated/Curated no putative metallopeptidase 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 2018-01-23 14:27:36 no Belongs to MEROPS peptidase family M23 (clan M-), subfamily M23B. 1 vladimir 0.333333 0.2414 0.277962 0.147287 0.51938 0.48062 0.313953 0.204319 0.378738 0.10299 0.583056 0.416944 0.42691 0.219269 0.172757 0.181063 0.392027 0.607973 0.259136 0.300664 0.282392 0.157807 0.583056 0.416944 0.627641 66406.33 -1.037105 0.294509 0.47421 0.156406 0.051581 0.429285 0.570715 0.347754 0.222962 0.124792 10.010429 9.204659 NMV_1064 2192026 CDS +3 1070613 1072097 1485 validated/Curated no prc ctpA carboxy-terminal processing protease (C-terminal processing protease) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 3.4.21.102 3.4.21.102-RXN 2018-01-23 14:28:39 no Shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. 1 vladimir 0.2633 0.2209 0.307744 0.208081 0.52862 0.47138 0.288889 0.161616 0.412121 0.137374 0.573737 0.426263 0.347475 0.226263 0.157576 0.268687 0.383838 0.616162 0.153535 0.274747 0.353535 0.218182 0.628283 0.371717 0.604167 53164.635 -0.395951 0.291498 0.544534 0.226721 0.05668 0.524291 0.475709 0.301619 0.163968 0.137652 9.053505 8.720648 NMV_1065 2192027 CDS +1 1072354 1074453 2100 validated/Curated no uvrB UvrABC system protein B (UvrB protein; excinuclease ABC subunit B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2621 2020-04-20 20:13:07 no During the process of E. coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products. 2 vladimir 0.264793 0.3171 0.237179 0.180966 0.554241 0.445759 0.255917 0.241124 0.369822 0.133136 0.610947 0.389053 0.35503 0.184911 0.162722 0.297337 0.347633 0.652367 0.183432 0.525148 0.178994 0.112426 0.704142 0.295858 0.727547 76760.44 -0.420296 0.231111 0.448889 0.231111 0.099259 0.515556 0.484444 0.314074 0.14963 0.164444 5.218758 9.77037 NMV_1066 2192028 CDS -1 1074494 1074694 201 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 16:55:46 no 3 vladimir 0.368159 0.1493 0.248756 0.233831 0.39801 0.60199 0.313433 0.208955 0.343284 0.134328 0.552239 0.447761 0.402985 0.134328 0.223881 0.238806 0.358209 0.641791 0.38806 0.104478 0.179104 0.328358 0.283582 0.716418 0.493014 7531.385 -0.759091 0.242424 0.409091 0.181818 0.075758 0.515152 0.484848 0.318182 0.212121 0.106061 9.915474 10.272727 NMV_1067 2192029 CDS -2 1074691 1074975 285 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 15:40:58 no 3 vladimir 0.417544 0.1298 0.217544 0.235088 0.347368 0.652632 0.368421 0.168421 0.336842 0.126316 0.505263 0.494737 0.442105 0.147368 0.168421 0.242105 0.315789 0.684211 0.442105 0.073684 0.147368 0.336842 0.221053 0.778947 0.46309 10835.965 -0.93617 0.212766 0.37234 0.212766 0.031915 0.414894 0.585106 0.393617 0.223404 0.170213 9.474129 9.574468 NMV_1068 2192030 CDS -1 1075727 1076443 717 validated/Curated no trmB tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.33 TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN 2018-01-23 14:31:16 no Catalyses the following reaction: S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing N(7)-methylguanine. 2 vladimir 0.281729 0.3361 0.230126 0.152022 0.566248 0.433752 0.267782 0.292887 0.330544 0.108787 0.623431 0.376569 0.334728 0.200837 0.196653 0.267782 0.39749 0.60251 0.242678 0.514644 0.16318 0.079498 0.677824 0.322176 0.658847 27122.705 -0.495378 0.256303 0.453782 0.197479 0.134454 0.516807 0.483193 0.298319 0.163866 0.134454 6.269676 9.533613 NMV_1069 2192031 CDS -3 1076565 1077968 1404 validated/Curated no conserved hypothetical TPR-containing protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-01-23 14:31:53 no Contains tetratrico peptide repeat (TPR) structural motifs, which mediate protein-protein interactions and the assembly of multiprotein complexes. 2 vladimir 0.2894 0.3110 0.233612 0.165969 0.54463 0.45537 0.194561 0.309623 0.345188 0.150628 0.654812 0.345188 0.393305 0.257322 0.156904 0.192469 0.414226 0.585774 0.280335 0.366109 0.198745 0.154812 0.564854 0.435146 0.600369 53841.48 -0.637736 0.293501 0.433962 0.15304 0.140461 0.557652 0.442348 0.253669 0.138365 0.115304 6.241264 10.331237 NMV_1070 2192032 CDS -2 1078087 1079973 1887 validated/Curated no uvrC UvrABC system protein C (UvrC protein; excinuclease ABC subunit C) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2621 2018-01-23 14:32:51 no During the process of E. coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products. 2 vladimir 0.274002 0.3177 0.235167 0.173139 0.552859 0.447141 0.26699 0.275081 0.325243 0.132686 0.600324 0.399676 0.355987 0.190939 0.187702 0.265372 0.378641 0.621359 0.199029 0.487055 0.192557 0.121359 0.679612 0.320388 0.738827 69801.8 -0.518152 0.252836 0.463533 0.205835 0.110211 0.515397 0.484603 0.285251 0.163695 0.121556 8.776329 9.658023 NMV_1071 2192033 CDS -2 1080028 1082205 2178 validated/Curated no putative cation-transporting ATPase 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 3.6.3.- 2018-01-23 12:30:22 no Is a P-type, or E1-E2-type, ATPase and belongs to a superfamily of cation transport enzymes whose members mediate membrane flux of all common biologically relevant cations. 1 vladimir 0.233701 0.2736 0.286961 0.205693 0.560606 0.439394 0.260331 0.177686 0.424242 0.137741 0.601928 0.398072 0.264463 0.257576 0.163912 0.31405 0.421488 0.578512 0.176309 0.385675 0.272727 0.165289 0.658402 0.341598 0.701652 76774.64 0.28731 0.346207 0.547586 0.248276 0.092414 0.630345 0.369655 0.201379 0.110345 0.091034 6.814629 8.911724 NMV_1072 2192034 CDS +1 1082344 1083294 951 validated/Curated no trxB thioredoxin reductase (TRXR) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 6 : Inner membrane-associated 1.6.15.2 : Thioredoxin, glutaredoxin ; 1.8.1.9 THIOREDOXIN-REDUCT-NADPH-RXN THIOREDOX-PWY 2018-01-23 14:33:50 no Reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase, which consequently reduces H2O2 to H2O. 2 vladimir 0.262881 0.2734 0.274448 0.189274 0.547844 0.452156 0.277603 0.170347 0.422713 0.129338 0.59306 0.40694 0.312303 0.233438 0.192429 0.26183 0.425868 0.574132 0.198738 0.416404 0.208202 0.176656 0.624606 0.375394 0.70828 33666.655 -0.122152 0.35443 0.544304 0.212025 0.082278 0.572785 0.427215 0.234177 0.110759 0.123418 5.15937 9.468354 NMV_1073 2192035 CDS +3 1083450 1083818 369 validated/Curated no rpsF 30S ribosomal protein S6 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-23 14:34:12 no Is one of the proteins from the small ribosomal subunit. 1 vladimir 0.289973 0.2466 0.233062 0.230352 0.479675 0.520325 0.284553 0.219512 0.365854 0.130081 0.585366 0.414634 0.373984 0.219512 0.121951 0.284553 0.341463 0.658537 0.211382 0.300813 0.211382 0.276423 0.512195 0.487805 0.80367 13934.465 -0.383607 0.237705 0.42623 0.221311 0.122951 0.516393 0.483607 0.319672 0.180328 0.139344 6.405754 10.114754 NMV_1074 2192036 CDS +3 1083819 1084121 303 validated/Curated no priB primosomal replication protein n 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.1 : DNA replication ; 2018-01-23 14:38:44 no Binds single-stranded DNA at the primosome assembly site. 1 vladimir 0.287129 0.1848 0.244224 0.283828 0.429043 0.570957 0.237624 0.257426 0.29703 0.207921 0.554455 0.445545 0.346535 0.148515 0.178218 0.326733 0.326733 0.673267 0.277228 0.148515 0.257426 0.316832 0.405941 0.594059 0.471116 11576.005 -0.182 0.19 0.36 0.28 0.11 0.58 0.42 0.23 0.13 0.1 8.106728 9.7 NMV_1075 2192037 CDS +3 1084128 1084358 231 validated/Curated no rpsR 30S ribosomal protein S18 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-23 14:39:06 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.324675 0.2597 0.181818 0.233766 0.441558 0.558442 0.272727 0.25974 0.272727 0.194805 0.532468 0.467532 0.363636 0.207792 0.142857 0.285714 0.350649 0.649351 0.337662 0.311688 0.12987 0.220779 0.441558 0.558442 0.778827 8992.235 -0.498684 0.223684 0.368421 0.197368 0.131579 0.5 0.5 0.328947 0.236842 0.092105 10.284828 9.236842 NMV_1076 2192038 CDS +1 1084375 1084827 453 validated/Curated no rplI 50S ribosomal protein L9 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2020-02-20 14:34:57 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.262693 0.2406 0.269316 0.227373 0.509934 0.490066 0.251656 0.139073 0.509934 0.099338 0.649007 0.350993 0.304636 0.264901 0.139073 0.291391 0.403974 0.596026 0.231788 0.317881 0.15894 0.291391 0.476821 0.523179 0.830164 15746.465 0.1 0.333333 0.553333 0.26 0.04 0.6 0.4 0.26 0.133333 0.126667 6.92347 9.726667 NMV_1078 2192040 CDS -1 1085615 1086421 807 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 16:51:53 no 2 vladimir 0.189591 0.3110 0.237918 0.261462 0.548947 0.451053 0.226766 0.226766 0.330855 0.215613 0.557621 0.442379 0.152416 0.289963 0.163569 0.394052 0.453532 0.546468 0.189591 0.416357 0.219331 0.174721 0.635688 0.364312 0.609266 27999.225 0.917164 0.376866 0.526119 0.291045 0.141791 0.735075 0.264925 0.097015 0.078358 0.018657 9.753548 7.690299 NMV_1079 2192041 CDS -1 1086422 1087168 747 validated/Curated no pss CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.1 : Phospholipid ; 2.7.8.8 PHOSPHASERSYN-RXN PWY-5669 2020-04-21 20:18:45 no Catalyses the following reaction: CDP-diacylglycerol + L-serine <=> CMP + 3-O-sn-phosphatidyl-L-serine. Is involved in phospholipid biosynthesis. 2 vladimir 0.196787 0.3146 0.24498 0.243641 0.559572 0.440428 0.261044 0.240964 0.285141 0.212851 0.526104 0.473896 0.200803 0.232932 0.188755 0.37751 0.421687 0.578313 0.128514 0.46988 0.261044 0.140562 0.730924 0.269076 0.658839 27908.965 0.551613 0.298387 0.459677 0.270161 0.16129 0.673387 0.326613 0.145161 0.100806 0.044355 9.87574 8.592742 NMV_1080 2192042 CDS -3 1087242 1087427 186 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-08 16:46:38 no 2 vladimir 0.295699 0.3763 0.198925 0.129032 0.575269 0.424731 0.354839 0.387097 0.16129 0.096774 0.548387 0.451613 0.306452 0.370968 0.193548 0.129032 0.564516 0.435484 0.225806 0.370968 0.241935 0.16129 0.612903 0.387097 0.604216 6596.21 -1.209836 0.278689 0.590164 0.098361 0.065574 0.508197 0.491803 0.196721 0.180328 0.016393 11.844276 9.803279 NMV_1081 2192043 CDS +2 1087751 1088233 483 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-08 16:46:25 no 1 vladimir 0.252588 0.2484 0.273292 0.225673 0.521739 0.478261 0.254658 0.173913 0.36646 0.204969 0.540373 0.459627 0.304348 0.285714 0.15528 0.254658 0.440994 0.559006 0.198758 0.285714 0.298137 0.217391 0.583851 0.416149 0.622044 17199.005 0.00125 0.38125 0.58125 0.2125 0.075 0.5625 0.4375 0.1875 0.1 0.0875 7.694969 9.73125 NMV_1082 2192044 CDS -1 1088285 1089496 1212 validated/Curated no putative uracil permease (uracil transporter) 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-23 14:42:31 no Belongs ot the family of xanthine/uracil permeases. 1 vladimir 0.179868 0.2723 0.284653 0.263201 0.556931 0.443069 0.272277 0.185644 0.373762 0.168317 0.559406 0.440594 0.143564 0.267327 0.165842 0.423267 0.433168 0.566832 0.123762 0.363861 0.314356 0.19802 0.678218 0.321782 0.721421 41826.44 1.01861 0.352357 0.563275 0.310174 0.099256 0.746898 0.253102 0.099256 0.059553 0.039702 8.912514 8.364764 NMV_1083 2192045 CDS +2 1089719 1092157 2439 validated/Curated no ftsK DNA translocase FtsK 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 5.1 : Cell division ; 2018-01-23 14:44:16 no Essential cell division protein that coordinates cell division and chromosome segregation. 2 vladimir 0.239852 0.2788 0.271013 0.210332 0.549816 0.450185 0.263223 0.214022 0.372694 0.150062 0.586716 0.413284 0.282903 0.244772 0.164822 0.307503 0.409594 0.590406 0.173432 0.377614 0.275523 0.173432 0.653137 0.346863 0.685016 87947.915 -0.024015 0.302956 0.527094 0.25 0.075123 0.57266 0.42734 0.232759 0.126847 0.105911 8.538994 8.965517 NMV_1084 2192046 CDS +2 1092365 1093675 1311 validated/Curated no tig trigger factor (TF) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-23 14:46:49 no Involved in protein export. Acts as a chaperone by maintaining the newly synthesised protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. 2 vladimir 0.295957 0.2395 0.250953 0.213577 0.490465 0.509535 0.235698 0.169336 0.462243 0.132723 0.631579 0.368421 0.366133 0.212815 0.125858 0.295195 0.338673 0.661327 0.286041 0.336384 0.16476 0.212815 0.501144 0.498856 0.840046 48219.575 -0.32133 0.25 0.511468 0.224771 0.071101 0.522936 0.477064 0.302752 0.126147 0.176606 4.725182 9.745413 NMV_1085 2192047 CDS +1 1093771 1094385 615 validated/Curated no clpP ATP-dependent Clp protease proteolytic subunit (endopeptidase Clp) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.2.3 : Proteins/peptides/glycopeptides ; 3.4.21.92 3.4.21.92-RXN 2020-02-19 14:10:24 no Catalyses the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. In the absence of ATP, only oligopeptides shorter than five residues are hydrolysed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). 1 vladimir 0.242276 0.2293 0.258537 0.269919 0.487805 0.512195 0.253659 0.185366 0.341463 0.219512 0.526829 0.473171 0.312195 0.195122 0.170732 0.321951 0.365854 0.634146 0.160976 0.307317 0.263415 0.268293 0.570732 0.429268 0.69936 22651.025 -0.131373 0.27451 0.465686 0.235294 0.093137 0.54902 0.45098 0.264706 0.122549 0.142157 5.049461 9.102941 NMV_1086 2192048 CDS -3 1094442 1095707 1266 validated/Curated no ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 1.17.7.3 RXN0-882 NONMEVIPP-PWY 2018-01-23 14:49:51 no Catalyses the sixth step of nonmevalonate terpenoid biosynthesis: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin <=> 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin. 1 vladimir 0.263033 0.2733 0.251185 0.21248 0.524487 0.475513 0.281991 0.201422 0.372038 0.14455 0.57346 0.42654 0.28673 0.248815 0.180095 0.28436 0.42891 0.57109 0.220379 0.369668 0.201422 0.208531 0.57109 0.42891 0.679794 45385.21 -0.142043 0.32304 0.539192 0.23753 0.054632 0.548694 0.451306 0.235154 0.118765 0.11639 5.993034 9.448931 NMV_1087 2192049 CDS -3 1095723 1096484 762 validated/Curated no pilW type IV pilus biogenesis lipoprotein PilW 1a : Function from experimental evidences in the studied strain f : factor 8 : Outer membrane-associated 6.5 : Pilus ; 2020-04-25 14:15:57 no 15612916, 18433773 Is important for the stability of secretin multimers. Is required for pilus biogenesis. 2 vladimir 0.279528 0.2927 0.227034 0.200787 0.519685 0.480315 0.240157 0.23622 0.314961 0.208661 0.551181 0.448819 0.366142 0.259843 0.141732 0.232283 0.401575 0.598425 0.232283 0.38189 0.224409 0.161417 0.606299 0.393701 0.646666 28423.33 -0.433992 0.29249 0.462451 0.177866 0.110672 0.557312 0.442688 0.225296 0.12253 0.102767 8.917 9.375494 NMV_1088 2192050 CDS -1 1096487 1097581 1095 validated/Curated no rlmN dual-specificity RNA methyltransferase RlmN 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.192 RXN-11586 2018-01-30 15:51:14 no 22891362 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimise ribosomal fidelity. 2 vladimir 0.26484 0.2603 0.254795 0.220091 0.515068 0.484932 0.276712 0.221918 0.320548 0.180822 0.542466 0.457534 0.317808 0.2 0.183562 0.29863 0.383562 0.616438 0.2 0.358904 0.260274 0.180822 0.619178 0.380822 0.675896 40932.355 -0.338736 0.263736 0.497253 0.211538 0.085165 0.527473 0.472527 0.241758 0.137363 0.104396 8.910912 9.931319 NMV_1089 2192051 CDS -2 1097725 1098150 426 validated/Curated no ndk nucleoside diphosphate kinase (NDK; NDP kinase; nucleoside-2-P kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.7.4.6 CDPKIN-RXN$DADPKIN-RXN$DCDPKIN-RXN$DGDPKIN-RXN$DTDPKIN-RXN$DUDPKIN-RXN$GDPKIN-RXN$NUCLEOSIDE-DIP-KIN-RXN$UDPKIN-RXN PPGPPMET-PWY$PWY-5687$PWY-6125$PWY-6126$PWY0-163$PWY0-166 2020-02-25 12:11:22 no Catalyses the following reaction: ATP + nucleoside diphosphate <=> ADP + nucleoside triphosphate. It is required for the synthesis of nucleoside triphosphates (NTP) other than ATP. 2 vladimir 0.2723 0.2629 0.246479 0.21831 0.50939 0.49061 0.309859 0.15493 0.401408 0.133803 0.556338 0.443662 0.309859 0.232394 0.15493 0.302817 0.387324 0.612676 0.197183 0.401408 0.183099 0.21831 0.584507 0.415493 0.715774 15410.09 -0.021986 0.304965 0.496454 0.219858 0.092199 0.574468 0.425532 0.248227 0.120567 0.12766 5.443062 9.666667 NMV_1090 2192052 CDS -1 1098209 1099360 1152 validated/Curated no putative ATPase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic ADENOSINETRIPHOSPHATASE-RXN$ATP-PYROPHOSPHATASE-RXN$ATPSYN-RXN$RXN0-1061$RXN0-4261 PWY-6126 2018-01-23 14:54:34 no Belongs to the AFG1-like family of ATPases. 2 vladimir 0.244792 0.2830 0.242188 0.230035 0.525174 0.474826 0.239583 0.257812 0.315104 0.1875 0.572917 0.427083 0.304688 0.21875 0.184896 0.291667 0.403646 0.596354 0.190104 0.372396 0.226562 0.210938 0.598958 0.401042 0.64015 43682.36 -0.304178 0.26893 0.446475 0.203655 0.13577 0.54047 0.45953 0.274151 0.148825 0.125326 6.654411 9.569191 NMV_1091 2192053 CDS -2 1099750 1100577 828 validated/Curated no frmB S-formylglutathione hydrolase FrmB 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 3.1.2.12 S-FORMYLGLUTATHIONE-HYDROLASE-RXN PWY-1801 2018-01-22 20:29:11 no Catalyses the following reaction: S-formylglutathione + H(2)O <=> glutathione + formateS-(hydroxymethyl)glutathione + NAD(P)(+) <=> S-formylglutathione + NAD(P)H. 1 vladimir 0.263285 0.2198 0.242754 0.274155 0.46256 0.53744 0.210145 0.23913 0.315217 0.235507 0.554348 0.445652 0.365942 0.202899 0.173913 0.257246 0.376812 0.623188 0.213768 0.217391 0.23913 0.32971 0.456522 0.543478 0.661406 31363.12 -0.394909 0.269091 0.443636 0.185455 0.167273 0.56 0.44 0.225455 0.12 0.105455 5.869133 9.84 NMV_1092 2192054 CDS -3 1100586 1101722 1137 validated/Curated no frmA S-(hydroxymethyl)glutathione dehydrogenase (putative alcohol dehydrogenase class III; glutathione-dependent formaldehyde dehydrogenase; FDH;FALDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.1.284 RXN-2962 PWY-1801 2018-01-22 20:27:24 no Catalyses the following reaction: S-(hydroxymethyl)glutathione + NAD(P)(+) <=> S-formylglutathione + NAD(P)H. 1 vladimir 0.26825 0.2172 0.265611 0.248901 0.48285 0.51715 0.248021 0.168865 0.403694 0.17942 0.572559 0.427441 0.295515 0.226913 0.192612 0.28496 0.419525 0.580475 0.261214 0.255937 0.200528 0.282322 0.456464 0.543536 0.719154 40519.445 -0.059788 0.335979 0.560847 0.222222 0.095238 0.574074 0.425926 0.230159 0.116402 0.113757 5.562691 9.65873 NMV_1093 2192055 CDS +3 1101843 1102250 408 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-23 14:57:24 no Belongs to the MerR family of bacterial regulatory proteins. 1 vladimir 0.32598 0.1985 0.208333 0.267157 0.406863 0.593137 0.294118 0.139706 0.308824 0.257353 0.448529 0.551471 0.382353 0.191176 0.147059 0.279412 0.338235 0.661765 0.301471 0.264706 0.169118 0.264706 0.433824 0.566176 0.664176 15354.1 -0.31037 0.266667 0.42963 0.22963 0.096296 0.525926 0.474074 0.281481 0.140741 0.140741 5.908226 9.377778 NMV_1094 2192056 CDS -1 1102601 1102915 315 validated/Curated no ihfB hip integration host factor beta subunit (IHF-beta) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2020-04-22 16:10:19 no This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. 2 vladimir 0.28254 0.2476 0.250794 0.219048 0.498413 0.501587 0.266667 0.219048 0.371429 0.142857 0.590476 0.409524 0.333333 0.190476 0.190476 0.285714 0.380952 0.619048 0.247619 0.333333 0.190476 0.228571 0.52381 0.47619 0.663836 11803.175 -0.590385 0.230769 0.461538 0.221154 0.086538 0.490385 0.509615 0.365385 0.230769 0.134615 9.982445 9.990385 NMV_1095 2192057 CDS -3 1102926 1104611 1686 validated/Curated no rpsA 30S ribosomal protein S1 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-23 15:00:40 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.289442 0.2580 0.250297 0.202254 0.508304 0.491696 0.261566 0.160142 0.441281 0.137011 0.601423 0.398577 0.346975 0.183274 0.163701 0.30605 0.346975 0.653025 0.259786 0.430605 0.145907 0.163701 0.576512 0.423488 0.898736 61173.81 -0.240107 0.276292 0.508021 0.256684 0.065954 0.515152 0.484848 0.30303 0.137255 0.165775 5.000221 9.035651 NMV_1096 2192058 CDS -1 1104767 1105423 657 validated/Curated no cmk cytidylate kinase (CK; cytidine monophosphate kinase; CMP kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.33.4 : Salvage pathways of pyrimidine ribonucleotides ; 2.7.4.25 RXN-11831$RXN-11832 P1-PWY$PWY0-163 2018-01-23 15:02:16 no Catalyses the following reaction: ATP + (d)CMP <=> ADP + (d)CDP. UMP and dCMP can also act as acceptors. 1 vladimir 0.26484 0.3044 0.258752 0.171994 0.563166 0.436834 0.205479 0.246575 0.429224 0.118721 0.675799 0.324201 0.296804 0.242009 0.191781 0.269406 0.43379 0.56621 0.292237 0.424658 0.155251 0.127854 0.579909 0.420091 0.672906 23761.245 -0.237615 0.311927 0.5 0.238532 0.059633 0.555046 0.444954 0.293578 0.151376 0.142202 7.952385 9.389908 NMV_1097 2192059 fCDS -1 1105667 1106476 810 validated/Curated pseudo putative sodium-dependent transporter (pseudogene part 3) 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 2008-06-18 16:21:58 no 1 vladimir 0.204938 0.2432 0.233333 0.318519 0.476543 0.523457 0.314815 0.159259 0.292593 0.233333 0.451852 0.548148 0.188889 0.22963 0.111111 0.47037 0.340741 0.659259 0.111111 0.340741 0.296296 0.251852 0.637037 0.362963 0.688899 29684.33 1.050558 0.282528 0.475836 0.334572 0.156134 0.695167 0.304833 0.115242 0.05948 0.055762 6.135628 7.858736 NMV_1097.1 2662685 fCDS -1 1106483 1106578 96 validated/Curated pseudo putative sodium-dependent transporter (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 2008-06-18 16:22:09 vladimir NMV_1098 2192060 fCDS -2 1106578 1106925 348 validated/Curated pseudo putative sodium-dependent transporter (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 2015-11-21 19:08:59 no 1 vladimir 0.212821 0.2026 0.294872 0.289744 0.497436 0.502564 0.3 0.130769 0.369231 0.2 0.5 0.5 0.184615 0.146154 0.253846 0.415385 0.4 0.6 0.153846 0.330769 0.261538 0.253846 0.592308 0.407692 0.673321 13792.92 0.817054 0.302326 0.496124 0.310078 0.124031 0.767442 0.232558 0.131783 0.085271 0.046512 9.322243 9.069767 NMNmiscRNA0156 54919237 misc_RNA -1 1107242 1107416 175 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 11:39:15 28334889 Function unknown. vladimir NMV_1100 2192062 CDS -1 1107527 1108219 693 validated/Curated no rsuA ribosomal small subunit pseudouridine synthase A (16S pseudouridylate 516 synthase; 16S pseudouridine 516 synthase; rRNA-uridine isomerase A; rRNA pseudouridylate synthase A) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.19 RXN-11833 2018-01-23 12:36:06 no The enzyme is specific for uridine(516) in 16S rRNA. The preferred substrate is a 5'-terminal fragment of 16S rRNA complexed with 30S ribosomal proteins. 2 vladimir 0.300144 0.2857 0.222222 0.191919 0.507937 0.492064 0.311688 0.233766 0.307359 0.147186 0.541126 0.458874 0.363636 0.199134 0.155844 0.281385 0.354978 0.645022 0.225108 0.424242 0.203463 0.147186 0.627706 0.372294 0.650284 26109.815 -0.401739 0.252174 0.486957 0.226087 0.117391 0.508696 0.491304 0.286957 0.152174 0.134783 5.9925 9.613043 NMV_1101 2192063 CDS -3 1108287 1110263 1977 validated/Curated no mltD membrane-bound lytic murein transglycosylase D (murein hydrolase D) 2a : Function from experimental evidences in other organisms e : enzyme 6 : Inner membrane-associated 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.2.1.- 2018-02-01 18:09:36 no Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. 2 vladimir 0.264036 0.3515 0.215984 0.168437 0.567527 0.432473 0.300455 0.261002 0.3217 0.116844 0.582701 0.417299 0.294385 0.289833 0.156297 0.259484 0.44613 0.553869 0.197269 0.503794 0.169954 0.128983 0.673748 0.326252 0.662543 72066.205 -0.272492 0.31155 0.539514 0.211246 0.085106 0.537994 0.462006 0.214286 0.12766 0.086626 9.560646 9.471125 NMV_1102 2192064 CDS +1 1110442 1111107 666 validated/Curated no putative methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-23 18:42:34 no Belongs to the family of SAM-dependent methyltransferases. Shows similarity to several ubiquinone/menaquinone biosynthesis C-methyltransferases. 1 vladimir 0.174174 0.2072 0.345345 0.273273 0.552553 0.447447 0.153153 0.22973 0.369369 0.247748 0.599099 0.400901 0.22973 0.22973 0.22973 0.310811 0.459459 0.540541 0.13964 0.162162 0.436937 0.261261 0.599099 0.400901 0.565546 24763.74 0.033032 0.294118 0.497738 0.20362 0.140271 0.656109 0.343891 0.226244 0.113122 0.113122 5.764885 9.660633 NMV_1103 2192065 CDS +1 1111159 1111986 828 validated/Curated no mutM fpg formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase MutM; AP lyase MutM) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.2.2.23, 4.2.99.18 RXN0-2602 2018-01-23 15:10:00 no Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. 1 vladimir 0.216184 0.2343 0.32971 0.219807 0.56401 0.43599 0.231884 0.246377 0.34058 0.181159 0.586957 0.413043 0.297101 0.184783 0.231884 0.286232 0.416667 0.583333 0.119565 0.271739 0.416667 0.192029 0.688406 0.311594 0.560532 30854.49 -0.281455 0.269091 0.469091 0.24 0.105455 0.567273 0.432727 0.28 0.170909 0.109091 9.225258 9.843636 NMV_1104 2192066 CDS +1 1112074 1112841 768 validated/Curated no plsC nlaA 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase; 1-AGPAT; lysophosphatidic acid acyltransferase; LPAAT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.1 : Phospholipid ; 2.3.1.51 1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN$RXN-1623$RXN0-5514$RXN0-6705 PWY-5667$PWY-5981$PWY0-1319$PWY4FS-7$PWY4FS-8 2020-02-23 20:07:09 no Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. 1 vladimir 0.214844 0.2539 0.302083 0.229167 0.55599 0.44401 0.246094 0.175781 0.378906 0.199219 0.554688 0.445312 0.242188 0.246094 0.222656 0.289062 0.46875 0.53125 0.15625 0.339844 0.304688 0.199219 0.644531 0.355469 0.635873 27856.05 -0.020392 0.32549 0.545098 0.231373 0.082353 0.580392 0.419608 0.25098 0.145098 0.105882 9.297997 9.439216 NMV_1105 2192067 CDS -1 1113152 1113463 312 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-08 16:40:47 no 1 vladimir 0.272436 0.2821 0.259615 0.185897 0.541667 0.458333 0.240385 0.259615 0.298077 0.201923 0.557692 0.442308 0.346154 0.259615 0.201923 0.192308 0.461538 0.538462 0.230769 0.326923 0.278846 0.163462 0.605769 0.394231 0.594537 11955.27 -0.866019 0.300971 0.417476 0.135922 0.116505 0.466019 0.533981 0.349515 0.242718 0.106796 10.193291 10.106796 NMV_1106 2192068 CDS +2 1113992 1116271 2280 validated/Curated no nrdA ribonucleoside-diphosphate reductase alpha subunit (ribonucleotide reductase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 1.17.4.1 ADPREDUCT-RXN$CDPREDUCT-RXN$GDPREDUCT-RXN$RIBONUCLEOSIDE-DIP-REDUCTI-RXN$RXN0-1$UDPREDUCT-RXN PWY-6125$PWY-6126$PWY0-166 2018-01-22 11:06:55 no Catalyses the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. 2 vladimir 0.258333 0.2807 0.242982 0.217982 0.523684 0.476316 0.259211 0.218421 0.336842 0.185526 0.555263 0.444737 0.348684 0.223684 0.159211 0.268421 0.382895 0.617105 0.167105 0.4 0.232895 0.2 0.632895 0.367105 0.696117 85220.49 -0.321739 0.283267 0.495389 0.220026 0.11726 0.537549 0.462451 0.262187 0.13307 0.129117 5.763069 9.575758 NMV_1107 2192069 CDS +3 1116237 1117217 981 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 15:59:41 no Similar to Abi proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species. 1 vladimir 0.296537 0.1667 0.246753 0.290043 0.41342 0.58658 0.272727 0.185065 0.292208 0.25 0.477273 0.522727 0.366883 0.149351 0.198052 0.285714 0.347403 0.652597 0.25 0.165584 0.25 0.334416 0.415584 0.584416 0.549028 36323.33 -0.536156 0.214984 0.400651 0.211726 0.162866 0.508143 0.491857 0.335505 0.198697 0.136808 9.173988 9.214984 NMNmiscRNA0166 54919399 misc_RNA -1 1117214 1117277 64 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:51:14 28334889 Function unknown. vladimir NMV_1108 2192070 CDS +3 1117410 1118564 1155 validated/Curated no nrdB ribonucleoside-diphosphate reductase beta subunit (ribonucleotide reductase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 1.17.4.1 ADPREDUCT-RXN$CDPREDUCT-RXN$GDPREDUCT-RXN$RIBONUCLEOSIDE-DIP-REDUCTI-RXN$RXN0-1$UDPREDUCT-RXN PWY-6125$PWY-6126$PWY0-166 2018-01-22 11:07:17 no Catalyses the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. 1 vladimir 0.269841 0.2319 0.244268 0.253968 0.47619 0.52381 0.259259 0.187831 0.328042 0.224868 0.515873 0.484127 0.37037 0.193122 0.126984 0.309524 0.320106 0.679894 0.179894 0.314815 0.277778 0.227513 0.592593 0.407407 0.716066 43256.45 -0.213263 0.230769 0.442971 0.238727 0.129973 0.538462 0.461538 0.257294 0.103448 0.153846 4.619011 9.461538 NMV_1109 2192071 CDS +2 1118762 1119052 291 validated/Curated no putative ferredoxin-like protein 3 : Putative function from multiple computational evidences c : carrier 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-23 15:13:28 no Is a member of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2). 1 vladimir 0.189003 0.1581 0.388316 0.264605 0.546392 0.453608 0.175258 0.164948 0.381443 0.278351 0.546392 0.453608 0.278351 0.123711 0.319588 0.278351 0.443299 0.556701 0.113402 0.185567 0.463918 0.237113 0.649485 0.350515 0.447976 10539.675 -0.113542 0.34375 0.489583 0.229167 0.072917 0.583333 0.416667 0.291667 0.114583 0.177083 4.612709 10.5 NMV_1110 2192072 CDS -3 1119093 1119371 279 validated/Curated no ftsB cell division protein FtsB 2a : Function from experimental evidences in other organisms f : factor 1 : Unknown 5.1 : Cell division ; 2018-01-23 15:15:15 no Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. 2 vladimir 0.297491 0.2509 0.225806 0.225806 0.476703 0.523297 0.268817 0.225806 0.322581 0.182796 0.548387 0.451613 0.376344 0.139785 0.193548 0.290323 0.333333 0.666667 0.247312 0.387097 0.16129 0.204301 0.548387 0.451613 0.574354 10573.585 -0.284783 0.25 0.434783 0.25 0.119565 0.521739 0.478261 0.23913 0.130435 0.108696 6.925072 10 NMV_1111 2192073 CDS -1 1119386 1120672 1287 validated/Curated no eno enolase (2-phosphoglycerate dehydratase; 2-phospho-D-glycerate hydro-lyase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 1.3.6 : Aerobic respiration ; 4.2.1.11 2PGADEHYDRAT-RXN ANAGLYCOLYSIS-PWY$ANARESP1-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2020-02-21 16:11:08 no Is a key glycolytic enzyme that catalyses the following reaction: 2-phospho-D-glycerate <=> phosphoenolpyruvate + H(2)O. 2 vladimir 0.266511 0.2898 0.260295 0.183372 0.550117 0.449883 0.258741 0.167832 0.414918 0.158508 0.582751 0.417249 0.333333 0.221445 0.172494 0.272727 0.393939 0.606061 0.207459 0.480186 0.193473 0.118881 0.67366 0.32634 0.809228 46152.295 -0.193224 0.324766 0.521028 0.212617 0.079439 0.560748 0.439252 0.254673 0.109813 0.14486 4.807213 9.551402 NMV_1112 2192074 CDS -2 1120720 1121160 441 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-08 16:38:58 no 1 vladimir 0.179138 0.2653 0.274376 0.281179 0.539683 0.460317 0.231293 0.210884 0.326531 0.231293 0.537415 0.462585 0.14966 0.258503 0.190476 0.401361 0.44898 0.55102 0.156463 0.326531 0.306122 0.210884 0.632653 0.367347 0.56458 15930.455 0.905479 0.349315 0.452055 0.287671 0.143836 0.732877 0.267123 0.116438 0.082192 0.034247 9.896141 8.308219 NMV_1113 2192075 CDS -3 1121175 1122017 843 validated/Curated no kdsA 2-dehydro-3-deoxyphosphooctonate aldolase (phospho-2-dehydro-3-deoxyoctonate aldolase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; KDO-8-phosphate synthetase; KDO 8-P synthase; KDOPS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.5.1.55 KDO-8PSYNTH-RXN KDO-NAGLIPASYN-PWY$PWY-1269 2018-01-23 15:17:39 no Catalyses the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, a part of the oligosaccharide core of lipooligosaccharide: phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O <=> 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. 2 vladimir 0.257414 0.2942 0.215896 0.232503 0.510083 0.489917 0.259786 0.220641 0.341637 0.177936 0.562278 0.437722 0.30605 0.217082 0.145907 0.330961 0.362989 0.637011 0.206406 0.44484 0.160142 0.188612 0.604982 0.395018 0.678092 30567.065 0.062143 0.278571 0.503571 0.264286 0.092857 0.571429 0.428571 0.246429 0.125 0.121429 5.621971 8.753571 NMV_1114 2192076 CDS -3 1122039 1122422 384 validated/Curated no panD aspartate 1-decarboxylase precursor (aspartate alpha-decarboxylase) [contains: aspartate 1-decarboxylase beta and alpha chains] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.23 : Pantothenate biosynthesis I ; 4.1.1.11 ASPDECARBOX-RXN PWY-5155 2018-01-23 15:19:09 no Catalyses the following reaction: L-aspartate <=> beta-alanine + CO(2). 2 vladimir 0.276042 0.2917 0.231771 0.200521 0.523437 0.476562 0.320312 0.171875 0.382812 0.125 0.554688 0.445312 0.328125 0.203125 0.15625 0.3125 0.359375 0.640625 0.179688 0.5 0.15625 0.164062 0.65625 0.34375 0.731567 13824.22 -0.031496 0.275591 0.543307 0.275591 0.07874 0.566929 0.433071 0.23622 0.11811 0.11811 5.546455 9.708661 NMV_1115 2192077 CDS -2 1122571 1126710 4140 validated/Curated no mfd transcription-repair coupling factor (TRCF) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.6.4.- 2018-01-30 14:58:52 no Couples transcription and DNA repair by recognising RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. 2 vladimir 0.242754 0.3072 0.261836 0.188164 0.569082 0.430918 0.230435 0.268116 0.366667 0.134783 0.634783 0.365217 0.310145 0.247826 0.168841 0.273188 0.416667 0.583333 0.187681 0.405797 0.25 0.156522 0.655797 0.344203 0.651231 151640.32 -0.282016 0.295141 0.498912 0.218274 0.094996 0.542422 0.457578 0.256708 0.129804 0.126904 5.67057 9.306019 NMV_1116 2192078 CDS +2 1126895 1128322 1428 validated/Curated no putative acyl-CoA dehydrogenase/oxidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-22 18:19:55 no Acyl-CoA dehydrogenase are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. 2 vladimir 0.243887 0.3031 0.25547 0.197555 0.558559 0.441441 0.243243 0.247104 0.34749 0.162162 0.594595 0.405405 0.316602 0.216216 0.179537 0.287645 0.395753 0.604247 0.171815 0.445946 0.239382 0.142857 0.685328 0.314672 0.658637 58326.95 -0.244874 0.276596 0.450677 0.216634 0.110251 0.55706 0.44294 0.276596 0.154739 0.121857 8.566978 9.866538 NMV_1118 2192080 CDS +2 1128524 1129633 1110 validated/Curated no mltB membrane-bound lytic murein transglycosylase B (murein hydrolase B) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.2.1.- RXN0-5190 2018-02-01 18:02:10 no Murein-degrading enzyme. Catalyses the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division. 1 vladimir 0.234642 0.2296 0.315206 0.220544 0.544814 0.455186 0.223565 0.151057 0.435045 0.190332 0.586103 0.413897 0.305136 0.238671 0.196375 0.259819 0.435045 0.564955 0.175227 0.299094 0.314199 0.21148 0.613293 0.386707 0.605932 36233.495 -0.228485 0.324242 0.545455 0.178788 0.139394 0.59697 0.40303 0.257576 0.136364 0.121212 7.937538 9.621212 NMV_1119 2192081 CDS -2 1129666 1130469 804 validated/Curated no IS1016 group transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2015-11-21 19:12:50 no 1 vladimir 0.276532 0.2242 0.243647 0.255605 0.467862 0.532138 0.29148 0.192825 0.32287 0.192825 0.515695 0.484305 0.336323 0.174888 0.201794 0.286996 0.376682 0.623318 0.201794 0.304933 0.206278 0.286996 0.511211 0.488789 0.644698 25144.835 -0.34955 0.261261 0.481982 0.220721 0.126126 0.518018 0.481982 0.301802 0.184685 0.117117 9.267021 9.238739 NMV_1120 2192082 CDS -2 1130476 1132482 2007 validated/Curated no putative site-specific recombinase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2018-01-23 15:23:21 no 9079926 2 vladimir 0.214748 0.3438 0.227703 0.213752 0.5715 0.4285 0.266069 0.273543 0.279522 0.180867 0.553064 0.446936 0.255605 0.209268 0.200299 0.334828 0.409567 0.590433 0.122571 0.54858 0.203288 0.125561 0.751868 0.248132 0.656899 74908.535 0.126647 0.293413 0.447605 0.255988 0.136228 0.594311 0.405689 0.22006 0.146707 0.073353 9.729729 8.91018 NMV_1121 2192083 CDS +1 1132771 1134798 2028 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-23 15:23:43 no Belongs to a family of transport proteins known as BCCT (for Betaine/Carnitine/Choline Transporters), which are specific for compounds containing a quaternary nitrogen atom. 1 vladimir 0.193787 0.2204 0.292406 0.293393 0.512821 0.487179 0.235207 0.196746 0.315089 0.252959 0.511834 0.488166 0.238166 0.193787 0.173077 0.39497 0.366864 0.633136 0.107988 0.27071 0.389053 0.232249 0.659763 0.340237 0.585843 76285.38 0.435852 0.271111 0.444444 0.281481 0.158519 0.638519 0.361481 0.183704 0.094815 0.088889 5.907799 8.684444 NMV_1122 2192084 CDS -2 1134889 1136442 1554 validated/Curated no fadD2 long-chain-fatty-acid-CoA ligase (long-chain acyl-CoA synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.1.2 : Fatty acids (fatty acid oxidation) ; 6.2.1.3 ACYLCOASYN-RXN$R223-RXN$RXN-12702$RXN-12746$RXN-7904$RXN-9623$RXN-9644$RXN-9673 FAO-PWY$PWY-5143$PWY-6944$PWY-6945$PWY-6946 2018-01-29 18:59:02 no Catalyses the following reaction: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA. 1 vladimir 0.246461 0.2844 0.261905 0.207207 0.546332 0.453668 0.285714 0.179537 0.364865 0.169884 0.544402 0.455598 0.297297 0.223938 0.160232 0.318533 0.38417 0.61583 0.156371 0.449807 0.260618 0.133205 0.710425 0.289575 0.709161 57603.58 -0.037911 0.272727 0.481625 0.235977 0.11412 0.586074 0.413926 0.259188 0.145068 0.11412 9.168541 9.29207 NMV_1123 2192085 CDS -1 1136729 1137922 1194 validated/Curated no putative TonB-dependent receptor 3 : Putative function from multiple computational evidences rc : receptor 8 : Outer membrane-associated 2018-01-23 15:26:20 no Contains a short conserved region at the N terminus, called the TonB-box, which is involved in the interaction of the protein with the TonB protein. In E. coli the TonB protein interacts with outer-membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space. 2 vladimir 0.227806 0.3543 0.261307 0.156616 0.615578 0.384422 0.281407 0.231156 0.354271 0.133166 0.585427 0.414573 0.261307 0.263819 0.223618 0.251256 0.487437 0.512563 0.140704 0.567839 0.20603 0.085427 0.773869 0.226131 0.722292 42734.49 -0.215617 0.370277 0.561713 0.193955 0.088161 0.554156 0.445844 0.188917 0.105793 0.083123 8.821617 9.292191 NMV_1124 2192086 CDS -2 1137919 1138905 987 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-08 16:36:25 no 2 vladimir 0.265451 0.3343 0.232016 0.168186 0.566363 0.433637 0.258359 0.264438 0.316109 0.161094 0.580547 0.419453 0.325228 0.25228 0.167173 0.255319 0.419453 0.580547 0.212766 0.486322 0.212766 0.088146 0.699088 0.300912 0.677342 36653.245 -0.390854 0.289634 0.490854 0.192073 0.128049 0.542683 0.457317 0.234756 0.128049 0.106707 7.492348 8.743902 NMV_1125 2192087 CDS -1 1138916 1140352 1437 validated/Curated no putative alginate O-acetylase AlgI ( poly(beta-D-mannuronate) O-acetylase; alginate biosynthesis protein AlgI) 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2.3.1.- 2018-01-22 19:16:59 no Belongs to the MBOAT (membrane bound O-acyl transferase) family of membrane proteins, which contains a variety of acyltransferase enzymes. 2 vladimir 0.168406 0.3118 0.255393 0.26444 0.567154 0.432846 0.185804 0.265136 0.298539 0.250522 0.563674 0.436326 0.196242 0.240084 0.192067 0.371608 0.43215 0.56785 0.123173 0.430063 0.275574 0.17119 0.705637 0.294363 0.673833 53376.785 0.57887 0.299163 0.472803 0.26569 0.1841 0.717573 0.282427 0.129707 0.087866 0.041841 9.542702 8.698745 NMV_1128 2192090 CDS +3 1140981 1141193 213 validated/Curated no putative heavy-metal scavenger protein 3 : Putative function from multiple computational evidences rc : receptor 2 : Cytoplasmic 2018-01-23 15:28:04 no Contains a Heavy-Metal-Associated (HMA) domain. 2 vladimir 0.267606 0.2441 0.314554 0.173709 0.558685 0.441315 0.28169 0.084507 0.521127 0.112676 0.605634 0.394366 0.28169 0.183099 0.253521 0.28169 0.43662 0.56338 0.239437 0.464789 0.169014 0.126761 0.633803 0.366197 0.67536 7074.695 0.242857 0.414286 0.628571 0.257143 0.028571 0.614286 0.385714 0.228571 0.071429 0.157143 4.21505 9.385714 NMV_1129 2192091 fCDS +3 1141341 1142732 1392 validated/Curated pseudo putative methyltransferase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 15:28:37 no Belongs to the family of S-adenosyl-L-methionine-dependent methyltransferases. 1 vladimir 0.265278 0.2306 0.263889 0.240278 0.494444 0.505556 0.260417 0.170833 0.366667 0.202083 0.5375 0.4625 0.347917 0.214583 0.15625 0.28125 0.370833 0.629167 0.1875 0.30625 0.26875 0.2375 0.575 0.425 0.632372 54194.39 -0.356994 0.26096 0.473904 0.204593 0.123173 0.54071 0.45929 0.2881 0.14405 0.14405 5.659248 9.682672 NMV_1130 2192092 fCDS +3 1142733 1142924 192 validated/Curated pseudo putative methyltransferase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 15:29:17 no Belongs to the family of S-adenosyl-L-methionine-dependent methyltransferases. 1 vladimir 0.252688 0.2366 0.268817 0.241935 0.505376 0.494624 0.258065 0.177419 0.33871 0.225806 0.516129 0.483871 0.290323 0.274194 0.112903 0.322581 0.387097 0.612903 0.209677 0.258065 0.354839 0.177419 0.612903 0.387097 0.586451 6810.51 0.037705 0.262295 0.508197 0.278689 0.098361 0.540984 0.459016 0.245902 0.098361 0.147541 4.589958 9.262295 NMV_1131 2192093 CDS +3 1143006 1144103 1098 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-07 17:32:28 no 1 vladimir 0.209472 0.2860 0.283242 0.221311 0.569217 0.430783 0.191257 0.29235 0.330601 0.185792 0.622951 0.377049 0.300546 0.256831 0.153005 0.289617 0.409836 0.590164 0.136612 0.308743 0.36612 0.188525 0.674863 0.325137 0.606418 40327.37 -0.125753 0.290411 0.50411 0.224658 0.112329 0.569863 0.430137 0.191781 0.10411 0.087671 6.135521 9.430137 NMV_1132 2192094 CDS +2 1144217 1145332 1116 validated/Curated no glxK glycerate kinase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.1.31 GLY3KIN-RXN 2018-01-23 15:30:36 no Catalyses the phosphorylation of (R)-glycerate to 3-phospho-(R)-glycerate in the presence of ATP. 3 vladimir 0.289427 0.1810 0.239247 0.290323 0.420251 0.579749 0.244624 0.182796 0.400538 0.172043 0.583333 0.416667 0.306452 0.201613 0.185484 0.306452 0.387097 0.612903 0.317204 0.158602 0.13172 0.392473 0.290323 0.709677 0.521792 39521.58 0.056065 0.315364 0.51752 0.261456 0.072776 0.590296 0.409704 0.234501 0.102426 0.132075 4.808815 8.859838 NMV_1133 2192095 CDS +3 1145457 1145912 456 validated/Curated no putative low molecular weight protein-tyrosine-phosphatase (PTPase; small, acidic phosphotyrosine protein phosphatase; PY protein phosphatase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.3.3 : Posttranslational modification ; 3.1.3.48 PROTEIN-TYROSINE-PHOSPHATASE-RXN 2018-01-23 15:31:27 no Acts on tyrosine phosphorylated proteins by catalysing the following reaction: protein tyrosine phosphate + H(2)O <=> protein tyrosine + phosphate. 2 vladimir 0.274123 0.2500 0.278509 0.197368 0.528509 0.471491 0.289474 0.177632 0.348684 0.184211 0.526316 0.473684 0.328947 0.217105 0.210526 0.243421 0.427632 0.572368 0.203947 0.355263 0.276316 0.164474 0.631579 0.368421 0.632033 16918.73 -0.462252 0.304636 0.463576 0.178808 0.10596 0.529801 0.470199 0.337748 0.178808 0.15894 6.485863 9.344371 NMV_1134 2192096 CDS +1 1145983 1146459 477 validated/Curated no putative cation uptake HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-23 15:32:07 no Belongs to the ferric uptake regulator or FUR family, which includes metal ion uptake regulator proteins binding to the operator DNA and control the transcription of metal ion-responsive genes. 1 vladimir 0.259958 0.2495 0.295597 0.194969 0.545073 0.454927 0.226415 0.220126 0.389937 0.163522 0.610063 0.389937 0.377358 0.188679 0.188679 0.245283 0.377358 0.622642 0.176101 0.339623 0.308176 0.176101 0.647799 0.352201 0.711837 17450.015 -0.239873 0.322785 0.474684 0.208861 0.120253 0.518987 0.481013 0.272152 0.14557 0.126582 5.762749 9.721519 NMV_1135 2192097 CDS +3 1146447 1147373 927 validated/Curated no putative GTPase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic RXN0-5462 2008-05-07 17:31:38 no 1 vladimir 0.275081 0.2794 0.254585 0.190939 0.533981 0.466019 0.265372 0.20712 0.372168 0.15534 0.579288 0.420712 0.320388 0.203883 0.168285 0.307443 0.372168 0.627832 0.239482 0.427184 0.223301 0.110032 0.650485 0.349515 0.706214 34069.865 -0.111688 0.272727 0.503247 0.237013 0.090909 0.564935 0.435065 0.256494 0.126623 0.12987 5.575829 8.915584 NMV_1136 2192098 CDS +1 1147438 1147995 558 validated/Curated no ppiA rotA peptidyl-prolyl cis-trans isomerase A (PPIase A; rotamase A; cyclophilin A) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-22 17:22:52 no PPIases accelerate the folding of proteins. It catalyses the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 2 vladimir 0.258065 0.2885 0.231183 0.222222 0.519713 0.480287 0.290323 0.155914 0.387097 0.166667 0.543011 0.456989 0.295699 0.258065 0.145161 0.301075 0.403226 0.596774 0.188172 0.451613 0.16129 0.198925 0.612903 0.387097 0.727572 20130.23 -0.110811 0.318919 0.578378 0.216216 0.097297 0.551351 0.448649 0.227027 0.135135 0.091892 9.549751 9.427027 NMV_1136.1 2609700 fCDS +2 1148111 1148278 168 validated/Curated pseudo putative type III restriction-modification system enzyme Mod (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 15:33:31 Belongs to the N4/N6-methyltransferase family. Specifically methylates the amino group at the C-6 position of adenines in DNA. vladimir NMV_1137 2192099 fCDS +3 1148298 1150160 1863 validated/Curated pseudo putative type III restriction-modification system enzyme Mod (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 15:33:22 no Belongs to the N4/N6-methyltransferase family. Specifically methylates the amino group at the C-6 position of adenines in DNA. 1 vladimir 0.31723 0.2222 0.220075 0.240472 0.442297 0.557703 0.310789 0.177134 0.334944 0.177134 0.512077 0.487923 0.383253 0.201288 0.138486 0.276973 0.339775 0.660225 0.257649 0.288245 0.186795 0.267311 0.47504 0.52496 0.591212 70014.485 -0.430484 0.25 0.474194 0.217742 0.112903 0.51129 0.48871 0.290323 0.137097 0.153226 5.144417 9.217742 NMV_1138 2192100 CDS +3 1150173 1153112 2940 validated/Curated no putative type III restriction-modification system enzyme Res 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.21.5 3.1.21.5-RXN 2018-01-23 15:34:00 no Belongs to the type III restriction-modification system Res protein family. Catalyses the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. 1 vladimir 0.304422 0.2313 0.24898 0.215306 0.480272 0.519728 0.304082 0.187755 0.338776 0.169388 0.526531 0.473469 0.395918 0.184694 0.140816 0.278571 0.32551 0.67449 0.213265 0.321429 0.267347 0.197959 0.588776 0.411224 0.668066 111498.24 -0.552809 0.236977 0.452503 0.202247 0.121553 0.490296 0.509704 0.314607 0.167518 0.147089 6.967583 9.093973 NMV_1139 2192101 CDS -1 1153148 1154164 1017 validated/Curated no ttcA tRNA-cytidine(32) 2-sulfurtransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2020-04-21 15:34:37 no Might catalyse the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s2C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. 1 vladimir 0.285152 0.2970 0.226155 0.19174 0.523107 0.476893 0.289086 0.244838 0.294985 0.171091 0.539823 0.460177 0.333333 0.215339 0.168142 0.283186 0.383481 0.616519 0.233038 0.430678 0.215339 0.120944 0.646018 0.353982 0.686685 38048.595 -0.418935 0.257396 0.470414 0.207101 0.091716 0.52071 0.47929 0.289941 0.171598 0.118343 9.32032 9 NMV_1140 2192102 CDS -3 1154262 1155128 867 validated/Curated no putative tRNA-modifying protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-23 15:37:08 no Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication. 2 vladimir 0.235294 0.2953 0.259516 0.209919 0.554787 0.445213 0.231834 0.217993 0.394464 0.155709 0.612457 0.387543 0.283737 0.256055 0.16263 0.297578 0.418685 0.581315 0.190311 0.411765 0.221453 0.176471 0.633218 0.366782 0.677057 31072.485 0.108681 0.329861 0.524306 0.236111 0.097222 0.604167 0.395833 0.21875 0.111111 0.107639 5.683174 9.524306 NMV_1141 2192103 CDS -2 1155160 1155522 363 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 15:37:59 no Belongs to the RutC-like superfamily. 2 vladimir 0.220386 0.2948 0.305785 0.179063 0.600551 0.399449 0.206612 0.165289 0.479339 0.14876 0.644628 0.355372 0.280992 0.280992 0.198347 0.239669 0.479339 0.520661 0.173554 0.438017 0.239669 0.14876 0.677686 0.322314 0.670676 13176.395 -0.163333 0.341667 0.558333 0.191667 0.091667 0.6 0.4 0.275 0.116667 0.158333 4.730522 10.683333 NMV_1142 2192104 CDS +1 1155598 1156077 480 validated/Curated no putative Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 16:00:33 no Might function in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. 2 vladimir 0.279167 0.2500 0.254167 0.216667 0.504167 0.495833 0.3125 0.20625 0.325 0.15625 0.53125 0.46875 0.325 0.20625 0.16875 0.3 0.375 0.625 0.2 0.3375 0.26875 0.19375 0.60625 0.39375 0.659306 17635.66 -0.200629 0.264151 0.465409 0.245283 0.119497 0.572327 0.427673 0.245283 0.150943 0.09434 9.1287 9.283019 NMV_1143 2192105 CDS +2 1156100 1156822 723 validated/Curated no putative DnaJ-like protein 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2018-01-23 15:40:42 no Contains a DnaJ domain (J-domain), which is associated with Hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. 1 vladimir 0.230982 0.2614 0.284924 0.222683 0.546335 0.453665 0.236515 0.228216 0.3361 0.19917 0.564315 0.435685 0.298755 0.20332 0.211618 0.286307 0.414938 0.585062 0.157676 0.352697 0.307054 0.182573 0.659751 0.340249 0.589602 27769.075 -0.265417 0.2625 0.4 0.204167 0.154167 0.595833 0.404167 0.266667 0.166667 0.1 9.8265 10.120833 NMV_1144 2192106 CDS +3 1156824 1157699 876 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-23 15:41:35 no Belongs to the drug/metabolite transporter (DMT) superfamily of permeases. 1 vladimir 0.206621 0.2283 0.294521 0.270548 0.522831 0.477169 0.270548 0.164384 0.359589 0.205479 0.523973 0.476027 0.178082 0.212329 0.174658 0.434932 0.386986 0.613014 0.171233 0.308219 0.349315 0.171233 0.657534 0.342466 0.641899 31000.17 1.075945 0.329897 0.498282 0.347079 0.109966 0.731959 0.268041 0.127148 0.089347 0.037801 9.685722 7.965636 NMV_1145 2192107 CDS -2 1157896 1159293 1398 validated/Curated no aspA aspartate ammonia-lyase (aspartase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.4 : Glutamate degradation ; 4.3.1.1 ASPARTASE-RXN GLUTDEG-PWY 2018-01-23 15:43:03 no Catalyses the following reaction: L-aspartate <=> fumarate + NH(3). 2 vladimir 0.261803 0.2883 0.242489 0.207439 0.530758 0.469242 0.272532 0.197425 0.371245 0.158798 0.56867 0.43133 0.321888 0.212446 0.145923 0.319743 0.358369 0.641631 0.190987 0.454936 0.2103 0.143777 0.665236 0.334764 0.746481 50757.42 0.007742 0.27957 0.516129 0.268817 0.068817 0.567742 0.432258 0.227957 0.109677 0.11828 5.329948 9.632258 NMV_1146 2192108 CDS -2 1159753 1160316 564 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-23 15:44:00 no Is one of the antigens in the Bexsero vaccine (GNA1030) that induces cross-reactive bactericidal antibodies against a number of N. meningitidis strains. 2 vladimir 0.287234 0.3351 0.203901 0.173759 0.539007 0.460993 0.335106 0.154255 0.367021 0.143617 0.521277 0.478723 0.345745 0.244681 0.143617 0.265957 0.388298 0.611702 0.180851 0.606383 0.101064 0.111702 0.707447 0.292553 0.865165 20406.29 -0.224064 0.336898 0.55615 0.187166 0.122995 0.524064 0.475936 0.251337 0.144385 0.106952 8.469032 8.909091 NMV_1147 2192109 CDS -2 1160479 1161549 1071 validated/Curated no leuB 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase; IMDH; 3-IPM-DH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.19 : Leucine ; 1.1.1.85 3-ISOPROPYLMALDEHYDROG-RXN LEUSYN-PWY 2018-01-23 15:44:49 no Catalyses the third step in the biosynthesis of leucine: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD(+) <=> 3-carboxy-4-methyl-2-oxopentanoate + NADH. 2 vladimir 0.242764 0.3231 0.237162 0.197012 0.560224 0.439776 0.22409 0.235294 0.383754 0.156863 0.619048 0.380952 0.32493 0.226891 0.165266 0.282913 0.392157 0.607843 0.179272 0.507003 0.162465 0.151261 0.669468 0.330532 0.787022 38994.865 -0.2 0.286517 0.491573 0.241573 0.078652 0.570225 0.429775 0.255618 0.115169 0.140449 4.952904 9.603933 NMV_1148 2192110 CDS -2 1161643 1162104 462 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:01:09 no 3 vladimir 0.292208 0.2446 0.238095 0.225108 0.482684 0.517316 0.311688 0.207792 0.318182 0.162338 0.525974 0.474026 0.344156 0.220779 0.168831 0.266234 0.38961 0.61039 0.220779 0.305195 0.227273 0.246753 0.532468 0.467532 0.571915 17394.18 -0.460784 0.248366 0.457516 0.189542 0.130719 0.535948 0.464052 0.30719 0.156863 0.150327 5.739037 9.542484 NMV_1149 2192111 CDS -1 1162169 1162861 693 validated/Curated no leuD 3-isopropylmalate dehydratase small subunit (isopropylmalate isomerase; alpha-IPM isomerase; IPMI) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.1.19 : Leucine ; 4.2.1.33 3-ISOPROPYLMALISOM-RXN$RXN-8991 LEUSYN-PWY 2018-01-23 15:46:28 no Catalyses the following reaction: (2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate. 2 vladimir 0.26324 0.3302 0.211838 0.194704 0.542056 0.457944 0.257009 0.247664 0.308411 0.186916 0.556075 0.443925 0.336449 0.205607 0.191589 0.266355 0.397196 0.602804 0.196262 0.537383 0.135514 0.130841 0.672897 0.327103 0.745958 24161.34 -0.483568 0.262911 0.474178 0.187793 0.13615 0.521127 0.478873 0.276995 0.140845 0.13615 5.699623 9.361502 NMV_1150 2192112 CDS -3 1162872 1163126 255 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-07 17:28:02 no 1 vladimir 0.298039 0.3373 0.247059 0.117647 0.584314 0.415686 0.294118 0.141176 0.458824 0.105882 0.6 0.4 0.341176 0.305882 0.188235 0.164706 0.494118 0.505882 0.258824 0.564706 0.094118 0.082353 0.658824 0.341176 0.744689 8727.385 -0.511905 0.440476 0.571429 0.142857 0.047619 0.511905 0.488095 0.27381 0.154762 0.119048 8.877693 9.380952 NMV_1151 2192113 CDS -3 1163223 1164632 1410 validated/Curated no leuC 3-isopropylmalate dehydratase large subunit (isopropylmalate isomerase; alpha-IPM isomerase; IPMI) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.19 : Leucine ; 4.2.1.33 3-ISOPROPYLMALISOM-RXN$RXN-8991 LEUSYN-PWY 2008-05-07 17:27:51 no 2 vladimir 0.253192 0.3057 0.261702 0.179433 0.567376 0.432624 0.270213 0.176596 0.410638 0.142553 0.587234 0.412766 0.293617 0.248936 0.195745 0.261702 0.444681 0.555319 0.195745 0.491489 0.178723 0.134043 0.670213 0.329787 0.780835 50811.62 -0.242644 0.341151 0.54371 0.191898 0.085288 0.552239 0.447761 0.264392 0.1258 0.138593 5.196861 9.759062 NMV_1152 2192114 CDS +1 1164892 1166241 1350 validated/Curated no putative glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.10 : Glutathione ; 6.3.2.2 GLUTCYSLIG-RXN GLUTATHIONESYN-PWY$PWY-4041 2018-01-23 15:48:42 no Belongs to a rare family of glutamate-cysteine ligases. It is the first of two enzymes for glutathione biosynthesis and catalyses the following reaction: ATP + L-glutamate + L-cysteine <=> ADP + phosphate + gamma-L-glutamyl-L-cysteine. 1 vladimir 0.248148 0.2578 0.271111 0.222963 0.528889 0.471111 0.24 0.195556 0.382222 0.182222 0.577778 0.422222 0.322222 0.217778 0.171111 0.288889 0.388889 0.611111 0.182222 0.36 0.26 0.197778 0.62 0.38 0.744037 49670.38 -0.227617 0.276169 0.514477 0.222717 0.104677 0.563474 0.436526 0.249443 0.11804 0.131403 5.186607 9.830735 NMV_1153 2192115 CDS +3 1166364 1167041 678 validated/Curated no putative DNA repair protein RadC 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-07 17:27:21 no 1 vladimir 0.221239 0.2419 0.328909 0.207965 0.570796 0.429204 0.243363 0.238938 0.367257 0.150442 0.606195 0.393805 0.261062 0.20354 0.199115 0.336283 0.402655 0.597345 0.159292 0.283186 0.420354 0.137168 0.70354 0.29646 0.529604 24989.9 0.016889 0.28 0.448889 0.275556 0.075556 0.56 0.44 0.257778 0.128889 0.128889 5.670784 9.368889 NMV_1154 2192116 CDS +3 1167114 1167839 726 validated/Curated no queH epoxyqueuosine reductase QueH 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 1.17.99.6 RXN-12104 PWY-6700 2018-01-23 15:52:28 no This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. 2 vladimir 0.275482 0.2755 0.246556 0.202479 0.522039 0.477961 0.264463 0.210744 0.326446 0.198347 0.53719 0.46281 0.380165 0.190083 0.202479 0.227273 0.392562 0.607438 0.181818 0.42562 0.210744 0.181818 0.636364 0.363636 0.71081 27923.6 -0.690456 0.253112 0.460581 0.141079 0.157676 0.53527 0.46473 0.315353 0.170124 0.145228 6.489067 10.419087 NMV_1155 2192117 CDS +2 1167992 1169272 1281 validated/Curated no conserved hypothetical membrane-associated protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-07 17:26:56 no 2 vladimir 0.249024 0.3021 0.266198 0.18267 0.568306 0.431694 0.222482 0.274005 0.346604 0.156909 0.620609 0.379391 0.332553 0.227166 0.220141 0.220141 0.447307 0.552693 0.192037 0.405152 0.23185 0.17096 0.637002 0.362998 0.568867 48005.105 -0.620657 0.295775 0.485915 0.173709 0.143192 0.539906 0.460094 0.2723 0.161972 0.110329 8.816917 10.420188 NMV_1156 2192118 CDS +3 1169277 1170455 1179 validated/Curated no hflX GTPase HflX 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; RXN0-5462 2018-01-30 15:16:11 no GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. 2 vladimir 0.245946 0.2964 0.283784 0.173874 0.58018 0.41982 0.262162 0.235135 0.383784 0.118919 0.618919 0.381081 0.289189 0.251351 0.191892 0.267568 0.443243 0.556757 0.186486 0.402703 0.275676 0.135135 0.678378 0.321622 0.639006 40008.04 -0.217615 0.336043 0.514905 0.235772 0.062331 0.520325 0.479675 0.276423 0.151762 0.124661 8.424706 9.355014 NMV_1157 2192119 CDS +2 1170452 1172923 2472 validated/Curated no putative copper-exporting P-type ATPase 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 7.2.2.8 2020-02-21 13:46:20 no Involved in copper export 2 vladimir 0.223301 0.3155 0.273463 0.187702 0.588997 0.411003 0.23665 0.246359 0.381068 0.135922 0.627427 0.372573 0.260922 0.246359 0.191748 0.300971 0.438107 0.561893 0.17233 0.453883 0.247573 0.126214 0.701456 0.298544 0.663563 89261.62 0.103038 0.329283 0.510328 0.251519 0.085055 0.603888 0.396112 0.218712 0.115431 0.103281 6.292641 9.512758 NMV_1159 2192121 CDS -2 1173580 1174356 777 validated/Curated no fpr ferredoxin-NADP reductase (FNR; flavodoxin reductase; FLXR; FLDR) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.18.1.2 FLAVONADPREDUCT-RXN$NRDACTMULTI-RXN 2018-01-22 11:22:40 no Catalyses the following reaction: 2 reduced ferredoxin + NADP(+) + H(+) <=> 2 oxidized ferredoxin + NADPH. 2 vladimir 0.275418 0.2819 0.232947 0.209781 0.514801 0.485199 0.258687 0.223938 0.335907 0.181467 0.559846 0.440154 0.343629 0.173745 0.166023 0.316602 0.339768 0.660232 0.223938 0.447876 0.196911 0.131274 0.644788 0.355212 0.763583 29312.565 -0.228682 0.244186 0.46124 0.236434 0.139535 0.546512 0.453488 0.294574 0.151163 0.143411 5.730598 9.100775 NMV_1160 2192122 CDS -3 1174545 1175339 795 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:01:42 no 2 vladimir 0.238994 0.2855 0.279245 0.196226 0.56478 0.43522 0.233962 0.267925 0.358491 0.139623 0.626415 0.373585 0.260377 0.264151 0.177358 0.298113 0.441509 0.558491 0.222642 0.324528 0.301887 0.150943 0.626415 0.373585 0.551771 29151.945 0.00303 0.291667 0.454545 0.25 0.079545 0.606061 0.393939 0.253788 0.147727 0.106061 9.398933 9.265152 NMV_1161 2192123 CDS -2 1175386 1176852 1467 validated/Curated no thrC threonine synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.8 : Threonine ; 4.2.3.1 THRESYN-RXN HOMOSER-THRESYN-PWY 2018-01-23 15:56:08 no Is involved in threonine biosynthesis by catalysing the following reaction: O-phospho-L-homoserine + H(2)O <=> L-threonine + phosphate. 2 vladimir 0.251064 0.2652 0.275177 0.208511 0.540426 0.459574 0.270213 0.178723 0.385106 0.165957 0.56383 0.43617 0.321277 0.229787 0.168085 0.280851 0.397872 0.602128 0.161702 0.387234 0.27234 0.178723 0.659574 0.340426 0.721005 51504.35 -0.21855 0.304904 0.530917 0.202559 0.10661 0.554371 0.445629 0.249467 0.119403 0.130064 5.229866 9.558635 NMV_1162 2192124 CDS -2 1176868 1177239 372 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-07 17:25:29 no 1 vladimir 0.239247 0.2742 0.306452 0.180108 0.580645 0.419355 0.290323 0.169355 0.379032 0.16129 0.548387 0.451613 0.25 0.241935 0.25 0.258065 0.491935 0.508065 0.177419 0.41129 0.290323 0.120968 0.701613 0.298387 0.710499 12992.49 -0.000813 0.406504 0.552846 0.186992 0.04878 0.593496 0.406504 0.203252 0.113821 0.089431 8.365852 9.853659 NMV_1163 2192125 CDS -3 1177491 1178960 1470 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-23 15:56:53 no Belongs to the major facilitator superfamily of transport proteins. 1 vladimir 0.192517 0.2218 0.297959 0.287755 0.519728 0.480272 0.222449 0.173469 0.355102 0.24898 0.528571 0.471429 0.179592 0.25102 0.195918 0.373469 0.446939 0.553061 0.17551 0.240816 0.342857 0.240816 0.583673 0.416327 0.632158 52617.16 0.623313 0.319018 0.521472 0.276074 0.130879 0.719836 0.280164 0.143149 0.083845 0.059305 8.190254 8.91002 NMV_1164 2192126 CDS +3 1179216 1180130 915 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-23 15:57:24 no Belongs to the LysR-family of transcriptional regulators. 2 vladimir 0.256831 0.2940 0.255738 0.193443 0.549727 0.450273 0.245902 0.278689 0.32459 0.15082 0.603279 0.396721 0.304918 0.229508 0.17377 0.291803 0.403279 0.596721 0.219672 0.373771 0.268852 0.137705 0.642623 0.357377 0.613216 33411.165 -0.082895 0.299342 0.470395 0.246711 0.105263 0.565789 0.434211 0.226974 0.134868 0.092105 7.835106 9.055921 NMV_1165 2192127 CDS -2 1180402 1181094 693 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:04:30 no 1 vladimir 0.333333 0.2294 0.206349 0.23088 0.435786 0.564214 0.393939 0.138528 0.324675 0.142857 0.463203 0.536797 0.359307 0.238095 0.134199 0.268398 0.372294 0.627706 0.246753 0.311688 0.160173 0.281385 0.471861 0.528139 0.54386 24410.225 -0.328696 0.330435 0.595652 0.23913 0.069565 0.469565 0.530435 0.217391 0.121739 0.095652 6.472191 8.7 NMV_1166 2192128 CDS -1 1181180 1181665 486 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:04:51 no 3 vladimir 0.360082 0.1543 0.195473 0.290123 0.349794 0.650206 0.327161 0.160494 0.308642 0.203704 0.469136 0.530864 0.419753 0.17284 0.123457 0.283951 0.296296 0.703704 0.333333 0.12963 0.154321 0.382716 0.283951 0.716049 0.538604 18189.73 -0.501242 0.21118 0.503106 0.242236 0.10559 0.490683 0.509317 0.26087 0.124224 0.136646 5.165886 8.726708 NMV_1167 2192129 CDS +1 1181914 1183224 1311 validated/Curated no rarA replication-associated recombination protein A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2018-01-23 15:59:40 no DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. 1 vladimir 0.230359 0.2830 0.279939 0.206712 0.562929 0.437071 0.194508 0.23341 0.382151 0.189931 0.615561 0.384439 0.315789 0.244851 0.167048 0.272311 0.411899 0.588101 0.180778 0.370709 0.290618 0.157895 0.661327 0.338673 0.657696 48334.245 -0.288991 0.279817 0.481651 0.21789 0.103211 0.566514 0.433486 0.277523 0.142202 0.135321 5.94326 9.419725 NMV_1168 2192130 CDS +3 1183338 1186343 3006 validated/Curated no putative type I restriction-modification system R protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.21.3 3.1.21.3-RXN 2018-01-23 16:00:35 no Is part of a type I restriction and modification system, which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 2 vladimir 0.307053 0.2818 0.202595 0.208583 0.484365 0.515635 0.287425 0.244511 0.307385 0.160679 0.551896 0.448104 0.404192 0.162675 0.139721 0.293413 0.302395 0.697605 0.229541 0.438124 0.160679 0.171657 0.598802 0.401198 0.662901 115782.21 -0.506194 0.20979 0.420579 0.228771 0.126873 0.493506 0.506494 0.302697 0.160839 0.141858 6.381187 9.357642 NMV_1169 2192131 CDS +1 1186450 1187625 1176 validated/Curated no putative type I restriction-modification system S protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 16:01:09 no Is part of a type I restriction and modification system, which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 3 vladimir 0.346287 0.1727 0.188256 0.292746 0.360967 0.639033 0.334197 0.168394 0.274611 0.222798 0.443005 0.556995 0.38601 0.181347 0.124352 0.30829 0.305699 0.694301 0.318653 0.168394 0.165803 0.34715 0.334197 0.665803 0.534407 44109.04 -0.282597 0.225974 0.444156 0.220779 0.137662 0.535065 0.464935 0.254545 0.145455 0.109091 8.888695 8.784416 NMV_1170 2192132 CDS +1 1187674 1189275 1602 validated/Curated no putative type I restriction-modification system M protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 16:01:34 no Is part of a type I restriction and modification system, which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 1 vladimir 0.303371 0.1998 0.23221 0.264669 0.43196 0.56804 0.322097 0.138577 0.331461 0.207865 0.470037 0.529963 0.382022 0.189139 0.116105 0.312734 0.305243 0.694757 0.205993 0.271536 0.249064 0.273408 0.520599 0.479401 0.678319 60012.09 -0.231332 0.253283 0.469043 0.225141 0.120075 0.510319 0.489681 0.287054 0.140713 0.146341 5.428856 8.669794 NMV_1171 2192133 CDS -1 1189583 1190920 1338 validated/Curated no ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 4.1.99.12 DIOHBUTANONEPSYN-RXN RIBOSYN2-PWY 2018-01-22 16:21:55 no Catalyses the following reaction: D-ribulose 5-phosphate <=> formate + L-3,4-dihydroxybutan-2-one 4-phosphate. 2 vladimir 0.253663 0.3489 0.235348 0.162088 0.584249 0.415751 0.269231 0.252747 0.379121 0.098901 0.631868 0.368132 0.296703 0.247253 0.156593 0.299451 0.403846 0.596154 0.195055 0.546703 0.17033 0.087912 0.717033 0.282967 0.736367 39352.59 -0.090909 0.305785 0.501377 0.231405 0.082645 0.567493 0.432507 0.247934 0.121212 0.126722 5.342552 9.305785 NMV_1172 2192134 fCDS -2 1191136 1191843 708 validated/Curated pseudo putative glycosyl transferase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.4.-.- 2018-01-22 18:37:45 no Belongs to family 2 of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates. 1 vladimir 0.278539 0.2317 0.219178 0.270548 0.450913 0.549087 0.284247 0.229452 0.232877 0.253425 0.462329 0.537671 0.321918 0.157534 0.191781 0.328767 0.349315 0.650685 0.229452 0.308219 0.232877 0.229452 0.541096 0.458904 0.49078 34210.77 -0.257045 0.202749 0.391753 0.237113 0.175258 0.56701 0.43299 0.274914 0.202749 0.072165 10.256203 8.876289 NMV_1173 2192135 fCDS -3 1191834 1192151 318 validated/Curated pseudo putative glycosyl transferase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.4.-.- 2018-01-22 18:37:26 no Belongs to family 2 of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates. 1 vladimir 0.266129 0.2151 0.258065 0.260753 0.473118 0.526882 0.274194 0.129032 0.346774 0.25 0.475806 0.524194 0.354839 0.16129 0.193548 0.290323 0.354839 0.645161 0.169355 0.354839 0.233871 0.241935 0.58871 0.41129 0.611839 13792.11 -0.138211 0.268293 0.504065 0.235772 0.130081 0.585366 0.414634 0.260163 0.121951 0.138211 5.03109 9.544715 NMV_1174 2192136 CDS -1 1192307 1192900 594 validated/Curated no ribA GTP cyclohydrolase II 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 3.5.4.25 GTP-CYCLOHYDRO-II-RXN RIBOSYN2-PWY 2018-01-22 16:18:41 no Catalyses the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. 2 vladimir 0.257576 0.2744 0.267677 0.200337 0.542088 0.457912 0.232323 0.262626 0.358586 0.146465 0.621212 0.378788 0.333333 0.191919 0.181818 0.292929 0.373737 0.626263 0.207071 0.368687 0.262626 0.161616 0.631313 0.368687 0.64546 21938.16 -0.260406 0.274112 0.472081 0.243655 0.091371 0.543147 0.456853 0.269036 0.137056 0.13198 5.70005 9.949239 NMV_1175 2192137 CDS -3 1192893 1193567 675 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-07 17:22:36 no 1 vladimir 0.2 0.2000 0.33037 0.26963 0.53037 0.46963 0.16 0.2 0.435556 0.204444 0.635556 0.364444 0.28 0.24 0.191111 0.288889 0.431111 0.568889 0.16 0.16 0.364444 0.315556 0.524444 0.475556 0.574924 24356.655 0.067857 0.330357 0.526786 0.241071 0.075893 0.589286 0.410714 0.236607 0.084821 0.151786 4.420235 9.861607 NMV_tRNA_26 2194841 tRNA +1 1193717 1193801 85 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:54:30 no tRNA Leu anticodon TAG. vladimir NMV_1177 2192139 CDS +1 1194322 1195356 1035 validated/Curated no purM phosphoribosylformylglycinamidine cyclo-ligase (AIRS; phosphoribosyl-aminoimidazole synthetase; AIR synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.3.1 AIRS-RXN PWY-6121 2018-01-23 16:03:38 no Catalyses the following reaction in the purine biosynthetic pathway: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine <=> ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. 1 vladimir 0.241546 0.2251 0.287923 0.245411 0.513043 0.486957 0.243478 0.15942 0.443478 0.153623 0.602899 0.397101 0.304348 0.194203 0.197101 0.304348 0.391304 0.608696 0.176812 0.321739 0.223188 0.278261 0.544928 0.455072 0.725057 36972.615 -0.037791 0.302326 0.540698 0.25 0.078488 0.59593 0.40407 0.25 0.107558 0.142442 4.758293 9.55814 NMV_1178 2192140 CDS -3 1195830 1196486 657 validated/Curated no putative two-component system transcriptional regulator protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-23 16:04:01 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. Belongs to the LuxR/FixJ family of response regulators. 2 vladimir 0.25723 0.3349 0.21309 0.194825 0.547945 0.452055 0.287671 0.296804 0.315068 0.100457 0.611872 0.388128 0.305936 0.205479 0.146119 0.342466 0.351598 0.648402 0.178082 0.502283 0.178082 0.141553 0.680365 0.319635 0.637353 23978.795 0.014679 0.256881 0.472477 0.293578 0.059633 0.541284 0.458716 0.243119 0.12844 0.114679 6.086388 8.802752 NMV_1179 2192141 CDS -1 1196483 1198255 1773 validated/Curated no putative two-component system sensor protein 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2.7.13.3 2.7.13.3-RXN 2018-01-22 20:07:40 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. 1 vladimir 0.266779 0.2662 0.245911 0.221094 0.512126 0.487874 0.240271 0.275804 0.314721 0.169205 0.590525 0.409475 0.311337 0.209814 0.170897 0.307953 0.380711 0.619289 0.248731 0.313029 0.252115 0.186125 0.565144 0.434856 0.578473 66514.415 -0.196949 0.267797 0.432203 0.247458 0.1 0.528814 0.471186 0.242373 0.120339 0.122034 5.498177 9.308475 NMV_1181 2192143 CDS +3 1198497 1199075 579 validated/Curated no mobA molybdenum cofactor guanylyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.4 : Molybdenum (molybdopterin) ; 2.7.7.77 RXN0-262 PWY-5964 2018-01-23 16:06:52 no Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Is specific for GTP since other nucleotides such as ATP and GMP cannot be utilised. 1 vladimir 0.233161 0.2314 0.29361 0.241796 0.525043 0.474957 0.26943 0.238342 0.295337 0.196891 0.533679 0.466321 0.295337 0.222798 0.186529 0.295337 0.409326 0.590674 0.134715 0.233161 0.398964 0.233161 0.632124 0.367876 0.519946 21804.235 -0.177083 0.265625 0.46875 0.223958 0.125 0.567708 0.432292 0.234375 0.130208 0.104167 6.646614 9.630208 NMV_1182 2192144 CDS +3 1199151 1199855 705 validated/Curated no ribC ribE riboflavin synthase alpha chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 2.5.1.9 RIBOFLAVIN-SYN-RXN RIBOSYN2-PWY 2018-01-23 16:07:42 no This enzyme synthesises riboflavin from two molecules of 6,7-dimethyl-8-(1'-D-ribityl)lumazine (Lum), a pteridine-derivative. 2 vladimir 0.262136 0.2524 0.283172 0.202265 0.535599 0.464401 0.296117 0.199029 0.373786 0.131068 0.572816 0.427184 0.286408 0.18932 0.208738 0.315534 0.398058 0.601942 0.203883 0.368932 0.26699 0.160194 0.635922 0.364078 0.585811 22580.98 -0.071707 0.292683 0.502439 0.24878 0.092683 0.556098 0.443902 0.263415 0.131707 0.131707 5.538445 9.84878 NMV_1183 2192145 CDS +1 1199863 1200726 864 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-07 17:20:30 no 1 vladimir 0.234954 0.2373 0.300926 0.226852 0.538194 0.461806 0.204861 0.225694 0.354167 0.215278 0.579861 0.420139 0.309028 0.215278 0.204861 0.270833 0.420139 0.579861 0.190972 0.270833 0.34375 0.194444 0.614583 0.385417 0.598732 32411.6 -0.35993 0.278746 0.473868 0.205575 0.125436 0.554007 0.445993 0.271777 0.139373 0.132404 5.933861 9.526132 NMV_1184 2192146 CDS -2 1200739 1201173 435 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-06 19:06:10 no 2 vladimir 0.216092 0.3034 0.227586 0.252874 0.531034 0.468966 0.213793 0.310345 0.255172 0.22069 0.565517 0.434483 0.296552 0.241379 0.17931 0.282759 0.42069 0.57931 0.137931 0.358621 0.248276 0.255172 0.606897 0.393103 0.61022 16588.465 -0.36875 0.263889 0.451389 0.194444 0.125 0.506944 0.493056 0.270833 0.173611 0.097222 9.299065 9.638889 NMV_1185 2192147 CDS +2 1201319 1202047 729 validated/Curated no rpe ribulose-phosphate 3-epimerase (pentose-5-phosphate 3-epimerase; PPE; R5P3E) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.3 : Pentose phosphate shunt, non-oxidative branch ; 5.1.3.1 RIBULP3EPIM-RXN NONOXIPENT-PWY$P21-PWY 2018-01-23 16:09:46 no Catalyses the following reaction in Calvin's reductive pentose phosphate cycle: D-ribulose 5-phosphate <=> D-xylulose 5-phosphate. 1 vladimir 0.230453 0.2497 0.292181 0.227709 0.541838 0.458162 0.26749 0.205761 0.395062 0.131687 0.600823 0.399177 0.263374 0.234568 0.168724 0.333333 0.403292 0.596708 0.160494 0.308642 0.312757 0.218107 0.621399 0.378601 0.640704 26258.275 0.172727 0.289256 0.528926 0.252066 0.090909 0.615702 0.384298 0.243802 0.115702 0.128099 5.116966 9.545455 NMV_1186 2192148 CDS -3 1202070 1203101 1032 validated/Curated no ruvB Holliday junction ATP-dependent DNA helicase RuvB 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.4.12 3.1.22.4-RXN 2018-01-22 16:50:03 no Forms a complex with RuvA. This complex is a helicase that mediates the Holliday junction migration by localised denaturation and re-annealing. 2 vladimir 0.229651 0.3459 0.25 0.174419 0.59593 0.40407 0.223837 0.287791 0.389535 0.098837 0.677326 0.322674 0.290698 0.229651 0.171512 0.30814 0.401163 0.598837 0.174419 0.520349 0.188953 0.116279 0.709302 0.290698 0.697047 37664.76 -0.143149 0.274052 0.483965 0.25656 0.069971 0.562682 0.437318 0.279883 0.137026 0.142857 5.403755 9.489796 NMV_1187 2192149 CDS -3 1203183 1203491 309 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:05:16 no 2 vladimir 0.275081 0.3074 0.226537 0.190939 0.533981 0.466019 0.271845 0.281553 0.300971 0.145631 0.582524 0.417476 0.378641 0.174757 0.15534 0.291262 0.330097 0.669903 0.174757 0.466019 0.223301 0.135922 0.68932 0.31068 0.690707 11769.935 -0.457843 0.196078 0.460784 0.22549 0.107843 0.519608 0.480392 0.284314 0.127451 0.156863 4.860085 9.931373 NMV_1188 2192150 CDS -3 1203714 1204967 1254 validated/Curated no cca multifunctional CCA protein [includes: CCA-adding enzyme (tRNA nucleotidyltransferase; tRNA adenylyl/cytidylyl-transferase; tRNA CCA-pyrophosphorylase; tRNA-NT) and 2'-nucleotidase and 2',3'-cyclic phosphodiesterase and phosphatase] 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.7.7.72, 3.1.3.-, 3.1.4.- TRNA-CYTIDYLYLTRANSFERASE-RXN 2018-01-31 00:03:54 no Catalyses the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. 2 vladimir 0.238437 0.3198 0.266348 0.175439 0.586124 0.413876 0.203349 0.296651 0.37799 0.12201 0.674641 0.325359 0.327751 0.229665 0.172249 0.270335 0.401914 0.598086 0.184211 0.433014 0.248804 0.133971 0.681818 0.318182 0.696026 46901.09 -0.371703 0.261391 0.455635 0.211031 0.105516 0.549161 0.450839 0.309353 0.177458 0.131894 8.232979 9.920863 NMV_1189 2192151 CDS -3 1205052 1206680 1629 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 2 : Cytoplasmic 2008-05-06 19:05:09 no 2 vladimir 0.279926 0.2603 0.257827 0.201964 0.518109 0.481891 0.263352 0.174954 0.377532 0.184162 0.552486 0.447514 0.377532 0.191529 0.149171 0.281768 0.3407 0.6593 0.198895 0.414365 0.246777 0.139963 0.661142 0.338858 0.795402 60834.545 -0.423801 0.261993 0.45941 0.208487 0.103321 0.52583 0.47417 0.291513 0.134686 0.156827 5.0532 9.560886 NMV_1190 2192152 CDS +2 1206830 1207204 375 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2020-02-19 13:04:42 no Is related to ArsC that is believed to catalyse the reduction of arsenate to arsenite. 2 vladimir 0.288 0.2587 0.266667 0.186667 0.525333 0.474667 0.28 0.216 0.328 0.176 0.544 0.456 0.336 0.208 0.192 0.264 0.4 0.6 0.248 0.352 0.28 0.12 0.632 0.368 0.613236 14013.635 -0.419355 0.282258 0.459677 0.193548 0.08871 0.524194 0.475806 0.282258 0.153226 0.129032 8.387535 9.645161 NMV_1191 2192153 CDS +1 1207264 1208802 1539 validated/Curated no putative peptidyl-prolyl cis-trans isomerase D (PPIase D; rotamase D) 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-22 17:23:58 no PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins. Its preference at the P1 position of the peptide substrate is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. 2 vladimir 0.288499 0.2762 0.248863 0.186485 0.525016 0.474984 0.259259 0.214425 0.382066 0.14425 0.596491 0.403509 0.387914 0.235867 0.107212 0.269006 0.34308 0.65692 0.218324 0.378168 0.25731 0.146199 0.635478 0.364522 0.713118 56578.665 -0.428125 0.261719 0.501953 0.214844 0.083984 0.503906 0.496094 0.269531 0.138672 0.130859 6.088951 9.066406 NMV_1193 2192155 CDS +1 1208869 1209486 618 validated/Curated no recR recombination protein RecR 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2606 2018-01-23 16:11:42 no Seems to play a role in a recombinational process of DNA repair. 1 vladimir 0.252427 0.2330 0.31068 0.203883 0.543689 0.456311 0.228155 0.203883 0.398058 0.169903 0.601942 0.398058 0.325243 0.208738 0.174757 0.291262 0.383495 0.616505 0.203883 0.286408 0.359223 0.150485 0.645631 0.354369 0.594812 22357.82 -0.040488 0.312195 0.492683 0.229268 0.092683 0.590244 0.409756 0.253659 0.131707 0.121951 5.877037 9.863415 NMV_1194 2192156 CDS -1 1209542 1209820 279 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2020-02-19 13:37:39 no Contains a TonB box, which is involved in the interaction with the TonB protein. TonB protein interacts with outer membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasm. 1 vladimir 0.258065 0.2796 0.275986 0.18638 0.555556 0.444444 0.333333 0.107527 0.408602 0.150538 0.516129 0.483871 0.268817 0.301075 0.193548 0.236559 0.494624 0.505376 0.172043 0.430108 0.225806 0.172043 0.655914 0.344086 0.659771 9221.085 0.232609 0.467391 0.641304 0.195652 0.043478 0.608696 0.391304 0.141304 0.076087 0.065217 7.902184 8.945652 NMV_1195 2192157 CDS +2 1210025 1211272 1248 validated/Curated no lolC lipoprotein-releasing system transmembrane protein LolC 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 1.6.10 : Lipoprotein ; 2018-01-30 16:58:58 no Part of an ATP-dependent transport system responsible for the translocation of lipoproteins targeted to the outer membrane from the inner membrane. 1 vladimir 0.198718 0.2428 0.309295 0.249199 0.552083 0.447917 0.25 0.1875 0.389423 0.173077 0.576923 0.423077 0.237981 0.223558 0.170673 0.367788 0.394231 0.605769 0.108173 0.317308 0.367788 0.206731 0.685096 0.314904 0.610009 45291.05 0.36241 0.289157 0.513253 0.289157 0.093976 0.636145 0.363855 0.19759 0.101205 0.096386 6.444954 9.344578 NMV_1196 2192158 CDS +3 1211265 1211960 696 validated/Curated no lolD lipoprotein-releasing system ATP-binding protein LolD 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 5 : Inner membrane protein 1.6.10 : Lipoprotein ; 3.6.3.- 2018-03-23 16:06:15 no Part of an ATP-dependent transport system responsible for the translocation of lipoproteins targeted to the outer membrane from the inner membrane. 1 vladimir 0.224138 0.2514 0.321839 0.202586 0.573276 0.426724 0.224138 0.262931 0.387931 0.125 0.650862 0.349138 0.288793 0.172414 0.228448 0.310345 0.400862 0.599138 0.159483 0.318966 0.349138 0.172414 0.668103 0.331897 0.636877 25215.06 -0.230303 0.294372 0.463203 0.246753 0.069264 0.549784 0.450216 0.307359 0.17316 0.134199 6.886513 9.705628 NMV_1197 2192159 CDS +1 1212028 1213773 1746 validated/Curated no recD exodeoxyribonuclease V alpha chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.11.5 RXN0-2605 2018-01-22 15:34:09 no Is a multisubunit enzyme comprised of the proteins RecB, RecC and RecD, which plays an important role in homologous genetic recombination, repair of double strand DNA breaks, resistance to UV irradiation and chemical DNA-damage. The enzyme catalyses hydrolysis of single-stranded (ss) DNA or double-stranded (ds) DNA and unwinding of the ends of dsDNA. Its nuclease activity is controlled by Chi sites (5' G-C-T-G-G-T-G-G 3') in such a way that the enzyme produces a potent single-stranded DNA substrate for homologous pairing by RecA and single-stranded DNA binding proteins. 1 vladimir 0.224513 0.2749 0.30126 0.199313 0.576174 0.423826 0.201031 0.226804 0.40378 0.168385 0.630584 0.369416 0.274914 0.266323 0.185567 0.273196 0.45189 0.54811 0.197595 0.331615 0.314433 0.156357 0.646048 0.353952 0.618951 62939.06 -0.086747 0.337349 0.518072 0.204819 0.10327 0.586919 0.413081 0.240964 0.120482 0.120482 5.551903 9.480207 NMV_1198 2192160 CDS -2 1213801 1214904 1104 validated/Curated no putative methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 16:13:58 no Belongs to the family of S-adenosyl-L-methionine-dependent methyltransferases. 1 vladimir 0.20304 0.2921 0.277959 0.226927 0.570033 0.429967 0.218241 0.270358 0.364821 0.14658 0.635179 0.364821 0.270358 0.28013 0.153094 0.296417 0.433225 0.566775 0.120521 0.325733 0.315961 0.237785 0.641694 0.358306 0.608773 33381.575 -0.060784 0.29085 0.503268 0.218954 0.104575 0.607843 0.392157 0.267974 0.163399 0.104575 9.515678 8.98366 NMV_1199 2192161 CDS +2 1215155 1217605 2451 validated/Curated no lon ATP-dependent protease Lon 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.4.21.53 3.4.21.53-RXN 2018-01-23 16:15:28 no ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. 1 vladimir 0.276214 0.2595 0.276622 0.187679 0.536108 0.463892 0.268054 0.214198 0.392901 0.124847 0.607099 0.392901 0.334149 0.215422 0.160343 0.290086 0.375765 0.624235 0.226438 0.348837 0.276622 0.148103 0.625459 0.374541 0.705041 90167.505 -0.291912 0.265931 0.468137 0.247549 0.064951 0.539216 0.460784 0.307598 0.158088 0.14951 6.190636 9.371324 NMV_1200 2192162 CDS +3 1217787 1218056 270 validated/Curated no hup DNA-binding protein HU 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.3.7 : Nucleoproteins, basic proteins ; 2018-01-23 16:16:24 no Histone-like DNA-binding protein which is capable of wrapping DNA to stabilise it, and thus to prevent its denaturation under extreme environmental conditions. 1 vladimir 0.288889 0.2926 0.237037 0.181481 0.52963 0.47037 0.288889 0.155556 0.433333 0.122222 0.588889 0.411111 0.311111 0.355556 0.122222 0.211111 0.477778 0.522222 0.266667 0.366667 0.155556 0.211111 0.522222 0.477778 0.84286 9315.22 -0.286517 0.404494 0.573034 0.179775 0.044944 0.52809 0.47191 0.258427 0.146067 0.11236 9.398613 9.05618 NMV_1201 2192163 CDS -2 1218115 1218549 435 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-06 19:02:15 no 2 vladimir 0.285057 0.2552 0.257471 0.202299 0.512644 0.487356 0.268966 0.213793 0.324138 0.193103 0.537931 0.462069 0.351724 0.234483 0.165517 0.248276 0.4 0.6 0.234483 0.317241 0.282759 0.165517 0.6 0.4 0.66184 16313.325 -0.439583 0.277778 0.4375 0.201389 0.0625 0.513889 0.486111 0.298611 0.173611 0.125 9.166512 9.368056 NMV_1202 2192164 CDS -1 1218542 1219849 1308 validated/Curated no hom homoserine dehydrogenase (HDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.21 : Homoserine ; 1.1.1.3 HOMOSERDEHYDROG-RXN HOMOSERSYN-PWY 2018-01-29 17:31:45 no Catalyses the following reaction: L-homoserine + NAD(P)(+) <=> L-aspartate 4-semialdehyde + NAD(P)H. This is the the third step in a pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine. 1 vladimir 0.261468 0.2913 0.261468 0.18578 0.552752 0.447248 0.288991 0.18578 0.415138 0.110092 0.600917 0.399083 0.288991 0.238532 0.162844 0.309633 0.401376 0.598624 0.206422 0.449541 0.206422 0.137615 0.655963 0.344037 0.786222 46543.74 0.118621 0.31954 0.514943 0.264368 0.064368 0.586207 0.413793 0.248276 0.11954 0.128736 5.305595 9.278161 NMV_1203 2192165 CDS +3 1220022 1220417 396 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:06:33 no 1 vladimir 0.25 0.2273 0.270202 0.252525 0.497475 0.502525 0.257576 0.234848 0.280303 0.227273 0.515152 0.484848 0.287879 0.212121 0.19697 0.30303 0.409091 0.590909 0.204545 0.234848 0.333333 0.227273 0.568182 0.431818 0.527022 14986.76 -0.241221 0.267176 0.442748 0.21374 0.129771 0.534351 0.465649 0.290076 0.167939 0.122137 7.416191 9.51145 NMV_1204 2192166 CDS +1 1220494 1222416 1923 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 2 : Cytoplasmic 2008-05-06 19:01:37 no 2 vladimir 0.274571 0.2850 0.234529 0.205928 0.519501 0.480499 0.24025 0.266771 0.327613 0.165367 0.594384 0.405616 0.366615 0.221529 0.145086 0.266771 0.366615 0.633385 0.216849 0.366615 0.230889 0.185647 0.597504 0.402496 0.678657 71719.675 -0.419531 0.275 0.428125 0.220312 0.089063 0.501563 0.498437 0.271875 0.140625 0.13125 6.001793 8.9875 NMNmiscRNA0167 54919400 misc_RNA +1 1222299 1222510 212 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:54:10 28334889 Function unknown. vladimir NMV_1205 2192167 CDS +1 1222882 1223397 516 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms ph : phenotype 9 : Periplasmic 6.5 : Pilus ; 2020-04-26 10:36:14 no Modulates pilus-mediated properties in N. meningitidis, but it is not required for pilus biogenesis. 2 vladimir 0.346899 0.2965 0.187984 0.168605 0.484496 0.515504 0.354651 0.244186 0.226744 0.174419 0.47093 0.52907 0.337209 0.296512 0.145349 0.22093 0.44186 0.55814 0.348837 0.348837 0.19186 0.110465 0.540698 0.459302 0.624673 18648.5 -0.618129 0.304094 0.538012 0.19883 0.046784 0.473684 0.526316 0.19883 0.134503 0.064327 9.824791 8.918129 NMV_1206 2192168 CDS +3 1223442 1223843 402 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-06 19:01:05 no 1 vladimir 0.271144 0.1965 0.243781 0.288557 0.440298 0.559701 0.365672 0.141791 0.19403 0.298507 0.335821 0.664179 0.238806 0.216418 0.246269 0.298507 0.462687 0.537313 0.208955 0.231343 0.291045 0.268657 0.522388 0.477612 0.4426 15087.22 0.140602 0.368421 0.488722 0.218045 0.150376 0.571429 0.428571 0.172932 0.150376 0.022556 9.830238 9.045113 NMV_1208 2192170 fCDS -1 1223963 1224958 996 validated/Curated pseudo putative type I restriction-modification system M protein (pseudogene part 4) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 16:20:50 no Is part of a type I restriction and modification system which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 2 vladimir 0.319577 0.2709 0.249735 0.159788 0.520635 0.479365 0.279365 0.228571 0.380952 0.111111 0.609524 0.390476 0.4 0.184127 0.168254 0.247619 0.352381 0.647619 0.279365 0.4 0.2 0.120635 0.6 0.4 0.67478 35562.745 -0.584395 0.267516 0.414013 0.210191 0.092357 0.474522 0.525478 0.33121 0.156051 0.175159 5.201561 9.111465 NMV_1209 2192171 fCDS -2 1225063 1225263 201 validated/Curated pseudo putative type I restriction-modification system M protein (pseudogene part 3) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 16:21:03 no Is part of a type I restriction and modification system which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 1 vladimir 0.288889 0.2381 0.219048 0.253968 0.457143 0.542857 0.247619 0.247619 0.32381 0.180952 0.571429 0.428571 0.361905 0.161905 0.171429 0.304762 0.333333 0.666667 0.257143 0.304762 0.161905 0.27619 0.466667 0.533333 0.571784 11837.975 -0.224038 0.230769 0.442308 0.240385 0.125 0.567308 0.432692 0.230769 0.105769 0.125 4.977043 9.951923 NMV_1210 2192172 fCDS -3 1225290 1225673 384 validated/Curated pseudo putative type I restriction-modification system M protein (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 16:21:18 no Is part of a type I restriction and modification system which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 2 vladimir 0.266247 0.2767 0.226415 0.230608 0.503145 0.496855 0.339623 0.238994 0.295597 0.125786 0.534591 0.465409 0.27044 0.201258 0.188679 0.339623 0.389937 0.610063 0.188679 0.389937 0.194969 0.226415 0.584906 0.415094 0.680986 17234.515 0.141772 0.278481 0.474684 0.291139 0.082278 0.594937 0.405063 0.227848 0.139241 0.088608 9.231346 8.594937 NMV_1211 2192173 fCDS -2 1225678 1226445 768 validated/Curated pseudo putative type I restriction-modification system M protein (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.72 2.1.1.72-RXN 2018-01-23 16:21:24 no Is part of a type I restriction and modification system which is composed of three polypeptides: R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognise specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. 2 vladimir 0.259259 0.2647 0.247277 0.228758 0.511983 0.488017 0.284314 0.179739 0.343137 0.19281 0.522876 0.477124 0.333333 0.245098 0.173203 0.248366 0.418301 0.581699 0.160131 0.369281 0.22549 0.245098 0.594771 0.405229 0.594305 33601.72 -0.365246 0.334426 0.521311 0.183607 0.101639 0.511475 0.488525 0.278689 0.154098 0.12459 8.17028 9.203279 NMV_1212 2192174 CDS -2 1226548 1227207 660 validated/Curated no ung uracil-DNA glycosylase (UDG) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.2.2.27 RXN0-2584 2020-02-19 13:41:41 no Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or by deamination of cytosine residues. 1 vladimir 0.233333 0.2606 0.269697 0.236364 0.530303 0.469697 0.213636 0.286364 0.295455 0.204545 0.581818 0.418182 0.304545 0.213636 0.195455 0.286364 0.409091 0.590909 0.181818 0.281818 0.318182 0.218182 0.6 0.4 0.561177 24828.4 -0.23653 0.26484 0.452055 0.228311 0.159817 0.56621 0.43379 0.237443 0.155251 0.082192 9.171959 9.287671 NMV_1213 2192175 CDS +3 1227288 1227695 408 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 19:00:29 no 1 vladimir 0.208333 0.2549 0.284314 0.252451 0.539216 0.460784 0.213235 0.191176 0.426471 0.169118 0.617647 0.382353 0.235294 0.272059 0.176471 0.316176 0.448529 0.551471 0.176471 0.301471 0.25 0.272059 0.551471 0.448529 0.582382 14360.97 0.454815 0.37037 0.548148 0.281481 0.118519 0.659259 0.340741 0.162963 0.088889 0.074074 6.338997 9.177778 NMV_1214 2192176 CDS +2 1227710 1228657 948 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-23 16:22:41 no Belongs to band 7 protein family. 1 vladimir 0.257384 0.2911 0.240506 0.21097 0.531646 0.468354 0.281646 0.205696 0.386076 0.126582 0.591772 0.408228 0.306962 0.246835 0.14557 0.300633 0.392405 0.607595 0.183544 0.420886 0.189873 0.205696 0.610759 0.389241 0.731686 34492.14 -0.036825 0.301587 0.48254 0.250794 0.063492 0.542857 0.457143 0.244444 0.120635 0.12381 5.638313 9.368254 NMV_1215 2192177 CDS -3 1228764 1229834 1071 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 18:59:52 no 1 vladimir 0.154062 0.2148 0.321195 0.309991 0.535948 0.464052 0.207283 0.201681 0.333333 0.257703 0.535014 0.464986 0.162465 0.19888 0.201681 0.436975 0.40056 0.59944 0.092437 0.243697 0.428571 0.235294 0.672269 0.327731 0.582612 38842.005 0.9 0.292135 0.463483 0.33427 0.129213 0.747191 0.252809 0.106742 0.070225 0.036517 9.951576 8.52809 NMV_1216 2192178 CDS +1 1230019 1230294 276 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 18:59:39 no 2 vladimir 0.293478 0.3116 0.221014 0.173913 0.532609 0.467391 0.293478 0.26087 0.315217 0.130435 0.576087 0.423913 0.358696 0.25 0.108696 0.282609 0.358696 0.641304 0.228261 0.423913 0.23913 0.108696 0.663043 0.336957 0.669848 10227.27 -0.368132 0.263736 0.505495 0.230769 0.10989 0.472527 0.527473 0.263736 0.153846 0.10989 6.558174 9.516484 NMV_1217 2192179 CDS +2 1230296 1230919 624 validated/Curated no lipB2 octanoyltransferase (lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferase; lipoate-protein ligase B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.3 : Lipoate ; 2.3.1.181 RXN0-947 PWY0-501 2018-01-22 19:19:40 no Catalyses the following reaction: octanoyl-[acyl-carrier-protein] + protein <=> protein N(6)-(octanoyl)lysine + [acyl-carrier-protein]. 2 vladimir 0.275641 0.2997 0.240385 0.184295 0.540064 0.459936 0.283654 0.235577 0.360577 0.120192 0.596154 0.403846 0.322115 0.235577 0.153846 0.288462 0.389423 0.610577 0.221154 0.427885 0.206731 0.144231 0.634615 0.365385 0.636491 22840.25 -0.204348 0.270531 0.516908 0.227053 0.10628 0.570048 0.429952 0.251208 0.130435 0.120773 5.799385 9.772947 NMV_1218 2192180 CDS +3 1230912 1231895 984 validated/Curated no lipA2 lipoyl synthase (lipoic acid synthase; lipoate synthase; lipoyl-acyl-carrier protein synthase; sulfur insertion protein LipA2; lip-syn) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.3 : Lipoate ; 2.8.1.8 RXN0-949 PWY0-501 2020-04-23 10:47:17 no Catalyses the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. 2 vladimir 0.284553 0.3222 0.224593 0.168699 0.546748 0.453252 0.295732 0.243902 0.326219 0.134146 0.570122 0.429878 0.341463 0.204268 0.185976 0.268293 0.390244 0.609756 0.216463 0.518293 0.161585 0.103659 0.679878 0.320122 0.708415 37031.26 -0.511621 0.250765 0.458716 0.195719 0.097859 0.519878 0.480122 0.333333 0.186544 0.146789 7.3144 9.923547 NMV_1219 2192181 CDS +3 1232358 1232822 465 validated/Curated no bfrA bacterioferritin A (BFR A) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 5.5.7 : Fe aquisition ; 1.16.3.1 RXN0-1483 2018-01-23 16:26:46 no Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidises them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex. 2 vladimir 0.290323 0.2710 0.245161 0.193548 0.516129 0.483871 0.219355 0.270968 0.36129 0.148387 0.632258 0.367742 0.419355 0.154839 0.148387 0.277419 0.303226 0.696774 0.232258 0.387097 0.225806 0.154839 0.612903 0.387097 0.775932 17960.605 -0.540909 0.227273 0.376623 0.220779 0.116883 0.493506 0.506494 0.324675 0.136364 0.188312 4.734474 10.298701 NMV_1220 2192182 CDS +3 1232850 1233323 474 validated/Curated no bfrB bacterioferritin B (BFR B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 5.5.7 : Fe aquisition ; 1.16.3.1 RXN0-1483 2018-01-23 16:28:00 no Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidises them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex. 2 vladimir 0.316456 0.2321 0.242616 0.208861 0.474684 0.525316 0.259494 0.234177 0.35443 0.151899 0.588608 0.411392 0.43038 0.132911 0.113924 0.322785 0.246835 0.753165 0.259494 0.329114 0.259494 0.151899 0.588608 0.411392 0.757438 18056.94 -0.319745 0.191083 0.33758 0.280255 0.089172 0.503185 0.496815 0.33121 0.133758 0.197452 4.663338 9 NMNmisc_RNA1233477D 19685064 misc_RNA +1 1233477 1233582 106 validated/Curated no AniS 1b : Function from experimental evidences in the studied species n : RNA 2 : Cytoplasmic 2018-01-28 17:13:45 21338417, 28334889 The synthesis of this sRNA is anaerobically induced through activation of its promoter by the FNR global regulator. vladimir NMV_1222 2192184 CDS +3 1233648 1233968 321 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2008-05-06 18:58:01 no 2 vladimir 0.23676 0.2430 0.311526 0.208723 0.554517 0.445483 0.242991 0.242991 0.317757 0.196262 0.560748 0.439252 0.299065 0.252336 0.17757 0.271028 0.429907 0.570093 0.168224 0.233645 0.439252 0.158879 0.672897 0.327103 0.65824 11963.315 -0.400943 0.264151 0.471698 0.207547 0.056604 0.54717 0.45283 0.235849 0.122642 0.113208 8.10363 10.339623 NMV_1223 2192185 CDS +3 1234017 1236575 2559 validated/Curated no glnD bifunctional uridylyltransferase/uridylyl-removing enzyme 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.7.59, 3.1.4.- URITRANS-RXN 2018-01-23 16:30:25 no Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyses the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyses PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. 2 vladimir 0.235248 0.3396 0.234857 0.190309 0.574443 0.425557 0.233294 0.298945 0.314185 0.153576 0.61313 0.38687 0.303634 0.215709 0.182884 0.297773 0.398593 0.601407 0.168816 0.504103 0.207503 0.119578 0.711606 0.288394 0.699065 96908.175 -0.231925 0.264085 0.450704 0.226526 0.131455 0.537559 0.462441 0.267606 0.153756 0.11385 7.562737 9.429577 NMV_1224 2192186 CDS +3 1236672 1237133 462 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:06:59 no 3 vladimir 0.367965 0.0779 0.203463 0.350649 0.281385 0.718615 0.363636 0.064935 0.279221 0.292208 0.344156 0.655844 0.402597 0.11039 0.175325 0.311688 0.285714 0.714286 0.337662 0.058442 0.155844 0.448052 0.214286 0.785714 0.407155 17614.23 -0.258824 0.248366 0.431373 0.20915 0.156863 0.54902 0.45098 0.228758 0.084967 0.143791 4.50013 9.614379 NMV_1225 2192187 CDS +2 1237460 1238923 1464 validated/Curated no guaB inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase; IMPDH; IMPD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 1.1.1.205 IMP-DEHYDROG-RXN PWY-6125 2018-01-23 16:32:13 no Catalyses the rate-limiting reaction of de novo GTP biosynthesis: inosine 5'-phosphate + NAD(+) + H(2)O <=> xanthosine 5'-phosphate + NADH. 2 vladimir 0.246585 0.3060 0.262978 0.184426 0.568989 0.431011 0.268443 0.206967 0.42418 0.10041 0.631148 0.368852 0.284836 0.237705 0.182377 0.295082 0.420082 0.579918 0.186475 0.473361 0.182377 0.157787 0.655738 0.344262 0.777312 52353.01 -0.112936 0.314168 0.542094 0.24846 0.067762 0.560575 0.439425 0.271047 0.147844 0.123203 6.765602 9.671458 NMV_1227 2192189 CDS -3 1239267 1241651 2385 validated/Curated no rnr vacB ribonuclease R (RNase R; VacB protein) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2 : RNA related ; 3.1.13.1 3.1.13.1-RXN 2018-01-22 20:34:07 no 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (rRNAs, tRNAs and SsrA/tmRNA). 1 vladimir 0.254507 0.2457 0.280084 0.219707 0.525786 0.474214 0.251572 0.208805 0.383648 0.155975 0.592453 0.407547 0.328302 0.187421 0.203774 0.280503 0.391195 0.608805 0.183648 0.340881 0.25283 0.222642 0.593711 0.406289 0.667333 89074.875 -0.404534 0.255668 0.47733 0.217884 0.099496 0.542821 0.457179 0.323678 0.185139 0.138539 9.137886 9.70403 NMV_tRNA_27 2194842 tRNA +1 1241740 1241826 87 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:54:51 no tRNA Leu anticodon CAG. vladimir NMV_tRNA_28 2194843 tRNA +1 1241862 1241948 87 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:55:00 no tRNA Leu anticodon CAG. vladimir NMV_tRNA_29 2194844 tRNA +1 1241987 1242077 91 validated/Curated no Ser tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:55:10 no tRNA Ser anticodon GGA. vladimir NMV_1229 2192191 CDS -3 1242642 1244453 1812 validated/Curated no putative GTP-binding protein TypA (tyrosine-phosphorylated protein A) 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-23 16:33:08 no Probably interacts with the ribosomes in a GTP dependent manner. 2 vladimir 0.253863 0.3002 0.267108 0.178808 0.567329 0.432671 0.269868 0.241722 0.375828 0.112583 0.61755 0.38245 0.32947 0.177152 0.188742 0.304636 0.365894 0.634106 0.162252 0.481788 0.236755 0.119205 0.718543 0.281457 0.767268 67256.81 -0.359038 0.245439 0.492537 0.247098 0.074627 0.522388 0.477612 0.293532 0.135987 0.157546 5.030983 9.736318 NMV_1231 2192193 CDS -1 1244723 1245613 891 validated/Curated no nnrD ADP-dependent (S)-NAD(P)H-hydrate dehydratase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 4.2.1.136 2018-01-23 16:36:41 no Catalyses the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. 1 vladimir 0.207632 0.2593 0.332211 0.200898 0.59147 0.40853 0.23569 0.175084 0.444444 0.144781 0.619529 0.380471 0.20202 0.306397 0.215488 0.276094 0.521886 0.478114 0.185185 0.296296 0.3367 0.181818 0.632997 0.367003 0.535711 30429.705 0.277027 0.422297 0.597973 0.222973 0.077703 0.64527 0.35473 0.192568 0.108108 0.084459 7.72274 9.304054 NMV_1232 2192194 CDS +3 1245678 1246334 657 validated/Curated no putative cytochrome 3 : Putative function from multiple computational evidences m : membrane component 5 : Inner membrane protein 2018-01-31 14:35:27 no Contains a haem-binding domain with a 4-helical bundle structure that is found in transmembrane di-haem cytochromes. 2 vladimir 0.203957 0.3257 0.226788 0.243531 0.552511 0.447489 0.255708 0.237443 0.305936 0.200913 0.543379 0.456621 0.210046 0.246575 0.182648 0.360731 0.429224 0.570776 0.146119 0.493151 0.191781 0.16895 0.684932 0.315068 0.621034 24200.615 0.447706 0.321101 0.472477 0.256881 0.169725 0.651376 0.348624 0.183486 0.142202 0.041284 10.286003 8.43578 NMV_1233 2192195 CDS +2 1246784 1248235 1452 validated/Curated no cysG siroheme synthase [includes: uroporphyrin-III C-methyltransferase (urogen III methylase; SUMT; uroporphyrinogen III methylase; UROM), precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 2.1.1.107, 1.3.1.76, 4.99.1.4 DIMETHUROPORDEHYDROG-RXN$RXN-8675$SIROHEME-FERROCHELAT-RXN$UROPORIIIMETHYLTRANSA-RXN PWY-5194 2018-01-23 16:38:55 no Is a multifunctional enzyme of the siroheme and cobalamin (vitamin B12) biosynthesis pathways, and represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. 2 vladimir 0.21281 0.3127 0.294766 0.179752 0.607438 0.392562 0.200413 0.268595 0.415289 0.115702 0.683884 0.316116 0.262397 0.252066 0.202479 0.283058 0.454545 0.545455 0.17562 0.417355 0.266529 0.140496 0.683884 0.316116 0.642587 52151.63 -0.078054 0.320911 0.521739 0.240166 0.080745 0.581781 0.418219 0.248447 0.142857 0.10559 9.424782 9.453416 NMV_1234 2192196 CDS +2 1248251 1248985 735 validated/Curated no cysH adenylyl-sulfate reductase (thioredoxin) (thioredoxin-dependent 5'-adenylylsulfate reductase; APS reductase; APS sulfotransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 1.8.4.10 1.8.4.8-RXN SO4ASSIM-PWY 2020-04-21 15:44:26 no 10613872 Like the enzyme in B. cepacia is not a PAPS reductase but an APS reductase. It catalyses the following reaction: AMP + sulfite + thioredoxin disulfide <=> 5'-adenylyl sulfate + thioredoxin. 1 vladimir 0.262585 0.2680 0.269388 0.2 0.537415 0.462585 0.265306 0.240816 0.338776 0.155102 0.579592 0.420408 0.330612 0.204082 0.232653 0.232653 0.436735 0.563265 0.191837 0.359184 0.236735 0.212245 0.595918 0.404082 0.626647 28061.795 -0.571311 0.270492 0.454918 0.184426 0.127049 0.52459 0.47541 0.32377 0.172131 0.151639 6.433739 10.02459 NMV_1235 2192197 CDS +3 1249023 1249946 924 validated/Curated no cysD sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase; SAT; ATP-sulfurylase small subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 2.7.7.4 SULFATE-ADENYLYLTRANS-RXN PWY-5340$SO4ASSIM-PWY 2018-01-23 16:49:52 no Catalyses the following reaction: ATP + sulfate <=> diphosphate + adenylyl sulfate. Is involved in the metabolic assimilation of sulfur from inorganic sulfate. 2 vladimir 0.248918 0.3084 0.278139 0.164502 0.58658 0.41342 0.262987 0.243506 0.353896 0.13961 0.597403 0.402597 0.295455 0.253247 0.185065 0.266234 0.438312 0.561688 0.188312 0.428571 0.295455 0.087662 0.724026 0.275974 0.650091 34753.35 -0.411401 0.276873 0.488599 0.214984 0.087948 0.508143 0.491857 0.306189 0.156352 0.149837 6.081581 9.889251 NMV_1236 2192198 CDS +2 1249985 1251271 1287 validated/Curated no cysN sulfate adenylyltransferase subunit 1 (sulfate adenylate transferase; SAT; ATP-sulfurylase large subunit) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 2.7.7.4 SULFATE-ADENYLYLTRANS-RXN PWY-5340$SO4ASSIM-PWY 2018-01-23 16:50:08 no Catalyses the following reaction: ATP + sulfate <=> diphosphate + adenylyl sulfate. Is involved in the metabolic assimilation of sulfur from inorganic sulfate. 2 vladimir 0.236208 0.3061 0.273504 0.184149 0.579643 0.420357 0.230769 0.249417 0.389277 0.130536 0.638695 0.361305 0.30303 0.251748 0.160839 0.284382 0.412587 0.587413 0.174825 0.417249 0.270396 0.137529 0.687646 0.312354 0.653829 46757.385 -0.168692 0.303738 0.523364 0.238318 0.084112 0.551402 0.448598 0.259346 0.126168 0.133178 5.355583 9.275701 NMV_1237 2192199 CDS +1 1251268 1253082 1815 validated/Curated no cysJ sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 1.8.1.2 NADPH-DEHYDROGENASE-FLAVIN-RXN$SULFITE-REDUCT-RXN SO4ASSIM-PWY 2018-01-23 16:51:15 no Catalyses the following reaction: H(2)S + 3 NADP(+) + 3 H(2)O <=> sulfite + 3 NADPH. Is involved in the metabolic assimilation of sulfur from inorganic sulfate. 1 vladimir 0.250689 0.2815 0.273278 0.19449 0.554821 0.445179 0.193388 0.25124 0.401653 0.153719 0.652893 0.347107 0.322314 0.26281 0.163636 0.25124 0.426446 0.573554 0.236364 0.330579 0.254545 0.178512 0.585124 0.414876 0.658501 66430.395 -0.336093 0.298013 0.511589 0.19702 0.110927 0.562914 0.437086 0.271523 0.13245 0.139073 5.346077 9.437086 NMV_1238 2192200 CDS +3 1253109 1254878 1770 validated/Curated no cysI sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP; SIRHP) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 1.8.1.2 SULFITE-REDUCT-RXN SO4ASSIM-PWY 2018-01-23 16:51:38 no Catalyses the following reaction: H(2)S + 3 NADP(+) + 3 H(2)O <=> sulfite + 3 NADPH. Is involved in the metabolic assimilation of sulfur from inorganic sulfate. 2 vladimir 0.246893 0.2972 0.272316 0.183616 0.569492 0.430508 0.252542 0.240678 0.354237 0.152542 0.594915 0.405085 0.313559 0.2 0.205085 0.281356 0.405085 0.594915 0.174576 0.450847 0.257627 0.116949 0.708475 0.291525 0.689442 65866.7 -0.394228 0.268251 0.487267 0.217317 0.10017 0.539898 0.460102 0.295416 0.16129 0.134126 8.087929 9.614601 NMV_1239 2192201 CDS +1 1255051 1256910 1860 validated/Curated no ilvD dihydroxy-acid dehydratase (DAD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 4.2.1.9 DIHYDROXYISOVALDEHYDRAT-RXN$DIHYDROXYMETVALDEHYDRAT-RXN ILEUSYN-PWY$VALSYN-PWY 2018-01-23 16:52:01 no Catalyses the fourth step in the biosynthesis of isoleucine and valine: 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O. 2 vladimir 0.246774 0.3177 0.262903 0.172581 0.580645 0.419355 0.274194 0.187097 0.398387 0.140323 0.585484 0.414516 0.290323 0.25 0.193548 0.266129 0.443548 0.556452 0.175806 0.516129 0.196774 0.11129 0.712903 0.287097 0.79905 66784.34 -0.172052 0.342488 0.53958 0.201939 0.082391 0.563813 0.436187 0.261712 0.134087 0.127625 5.775139 9.877221 NMV_1240 2192202 CDS +1 1257556 1258122 567 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:07:26 no 2 vladimir 0.275132 0.2857 0.229277 0.209877 0.514991 0.485009 0.333333 0.137566 0.359788 0.169312 0.497354 0.502646 0.306878 0.222222 0.169312 0.301587 0.391534 0.608466 0.185185 0.497355 0.15873 0.15873 0.656085 0.343915 0.666923 20499.655 -0.108511 0.303191 0.510638 0.228723 0.117021 0.56383 0.43617 0.25 0.148936 0.101064 9.466866 8.664894 NMV_1241 2192203 CDS -1 1258250 1259215 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-23 16:52:30 no Belongs to the IS30 family. 2 vladimir 0.321946 0.3075 0.206004 0.164596 0.513458 0.486542 0.34472 0.295031 0.214286 0.145963 0.509317 0.490683 0.381988 0.173913 0.226708 0.217391 0.400621 0.599379 0.23913 0.453416 0.177019 0.130435 0.630435 0.369565 0.56321 38033.11 -0.916822 0.249221 0.392523 0.193146 0.130841 0.417445 0.582555 0.327103 0.23676 0.090343 10.146294 9.76947 NMV_1243 2192205 CDS -3 1259352 1260602 1251 validated/Curated no bioB biotin synthase (biotin synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 2.8.1.6 2.8.1.6-RXN PWY0-1507 2018-01-23 16:52:54 no Catalyses the last step of the biotin biosynthetic pathway: dethiobiotin + sulfur <=> biotin. 2 vladimir 0.250712 0.2821 0.280152 0.187085 0.562203 0.437797 0.270655 0.207977 0.37037 0.150997 0.578348 0.421652 0.327635 0.219373 0.190883 0.262108 0.410256 0.589744 0.153846 0.418803 0.279202 0.148148 0.698006 0.301994 0.668845 38878.945 -0.385714 0.288571 0.508571 0.194286 0.082857 0.545714 0.454286 0.291429 0.142857 0.148571 5.437294 10.162857 NMV_1245 2192207 CDS -1 1260611 1261987 1377 validated/Curated no mpl UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase (murein peptide ligase) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 6.3.2.45 RXN0-2361 2018-01-23 16:53:33 no Catalyses the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. 2 vladimir 0.224401 0.2905 0.289034 0.196078 0.579521 0.420479 0.237473 0.200436 0.416122 0.145969 0.616558 0.383442 0.291939 0.222222 0.1939 0.291939 0.416122 0.583878 0.143791 0.448802 0.257081 0.150327 0.705882 0.294118 0.710344 49527.385 -0.039301 0.320961 0.530568 0.218341 0.122271 0.598253 0.401747 0.244541 0.131004 0.113537 5.942513 9.5131 NMV_1246 2192208 CDS -3 1262049 1262351 303 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-06 13:02:41 no 1 vladimir 0.287129 0.2013 0.323432 0.188119 0.524752 0.475248 0.306931 0.158416 0.405941 0.128713 0.564356 0.435644 0.346535 0.277228 0.207921 0.168317 0.485149 0.514851 0.207921 0.168317 0.356436 0.267327 0.524752 0.475248 0.504094 10746.445 -0.74 0.38 0.63 0.15 0.08 0.46 0.54 0.29 0.18 0.11 9.008217 10.15 NMV_1247 2192209 CDS -3 1262364 1262561 198 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-06 13:02:28 no 1 vladimir 0.19697 0.1768 0.292929 0.333333 0.469697 0.530303 0.242424 0.121212 0.242424 0.393939 0.363636 0.636364 0.212121 0.242424 0.166667 0.378788 0.409091 0.590909 0.136364 0.166667 0.469697 0.227273 0.636364 0.363636 0.60735 7572.92 0.632308 0.261538 0.384615 0.261538 0.2 0.738462 0.261538 0.153846 0.123077 0.030769 9.84594 7.907692 NMV_1248 2192210 CDS -3 1262571 1263356 786 validated/Curated no putative tRNA/rRNA methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.- 2018-01-22 18:45:56 no 1 vladimir 0.206107 0.2239 0.340967 0.229008 0.564885 0.435115 0.206107 0.175573 0.423664 0.194656 0.599237 0.400763 0.267176 0.21374 0.21374 0.305344 0.427481 0.572519 0.145038 0.282443 0.385496 0.187023 0.667939 0.332061 0.608453 28161.31 0.075479 0.314176 0.54023 0.260536 0.088123 0.605364 0.394636 0.249042 0.137931 0.111111 7.186119 9.463602 NMV_1249 2192211 CDS -2 1263430 1264740 1311 validated/Curated no tilS tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidine synthetase; tRNA(Ile)-2-lysyl-cytidine synthase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 6.3.4.19 RXN-1961 2018-01-18 17:50:47 no Ligates a lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. 1 vladimir 0.225605 0.2272 0.288056 0.259173 0.515222 0.484778 0.213115 0.238876 0.34192 0.206089 0.580796 0.419204 0.297424 0.18267 0.215457 0.30445 0.398126 0.601874 0.166276 0.259953 0.306792 0.266979 0.566745 0.433255 0.578738 47849.315 -0.19108 0.251174 0.467136 0.244131 0.124413 0.577465 0.422535 0.279343 0.169014 0.110329 9.036095 9.366197 NMV_1250 2192212 CDS -1 1264808 1265767 960 validated/Curated no accA acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase alpha chain) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; 6.4.1.2 ACETYL-COA-CARBOXYLTRANSFER-RXN$RXN0-5055 PWY-4381$PWY0-1264 2018-01-23 16:54:52 no Catalyses the first step in the synthesis of long-chain fatty acids: ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA. 2 vladimir 0.244792 0.2719 0.264583 0.21875 0.536458 0.463542 0.23125 0.23125 0.36875 0.16875 0.6 0.4 0.33125 0.221875 0.1625 0.284375 0.384375 0.615625 0.171875 0.3625 0.2625 0.203125 0.625 0.375 0.708418 35444.08 -0.321317 0.278997 0.479624 0.216301 0.103448 0.539185 0.460815 0.285266 0.15047 0.134796 6.287834 9.30094 NMV_1253 2192215 CDS +2 1265978 1266379 402 validated/Curated no hslR heat shock protein 15 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2018-01-23 16:56:43 no Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome. 2 vladimir 0.308458 0.2811 0.236318 0.174129 0.517413 0.482587 0.320896 0.276119 0.261194 0.141791 0.537313 0.462687 0.380597 0.201493 0.19403 0.223881 0.395522 0.604478 0.223881 0.365672 0.253731 0.156716 0.619403 0.380597 0.567908 15642.36 -1.032331 0.233083 0.406015 0.18797 0.097744 0.406015 0.593985 0.390977 0.263158 0.12782 10.305016 8.977444 NMV_1254 2192216 CDS -3 1266447 1266644 198 validated/Curated no iscX protein IscX 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2017-10-25 23:55:53 no 20404999 May function as iron donor in the assembly of iron-sulfur clusters. 2 vladimir 0.262626 0.3131 0.262626 0.161616 0.575758 0.424242 0.212121 0.272727 0.393939 0.121212 0.666667 0.333333 0.363636 0.212121 0.166667 0.257576 0.378788 0.621212 0.212121 0.454545 0.227273 0.106061 0.681818 0.318182 0.728363 7662.37 -0.62 0.215385 0.415385 0.2 0.092308 0.492308 0.507692 0.384615 0.138462 0.246154 4.37719 10.569231 NMV_1255 2192217 CDS +2 1266857 1267411 555 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:07:52 no 1 vladimir 0.234234 0.2793 0.27027 0.216216 0.54955 0.45045 0.216216 0.243243 0.362162 0.178378 0.605405 0.394595 0.27027 0.259459 0.194595 0.275676 0.454054 0.545946 0.216216 0.335135 0.254054 0.194595 0.589189 0.410811 0.587678 20467.885 -0.113587 0.320652 0.483696 0.222826 0.097826 0.576087 0.423913 0.255435 0.152174 0.103261 9.251534 9.940217 NMV_1256 2192218 CDS -3 1267731 1268072 342 validated/Curated no fdx 2Fe-2S ferredoxin 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-23 16:58:58 no Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron-sulfur proteins. 2 vladimir 0.269006 0.2982 0.251462 0.181287 0.549708 0.450292 0.219298 0.210526 0.421053 0.149123 0.631579 0.368421 0.350877 0.219298 0.157895 0.27193 0.377193 0.622807 0.236842 0.464912 0.175439 0.122807 0.640351 0.359649 0.718095 12460.6 -0.154867 0.283186 0.522124 0.256637 0.079646 0.522124 0.477876 0.345133 0.123894 0.221239 4.383492 9.80531 NMV_1257 2192219 fCDS -3 1268127 1268417 291 validated/Curated pseudo conserved hypothetical ANK repeat-containing protein (pseudogene part 2) 3 : Putative function from multiple computational evidences u : unknown 2 : Cytoplasmic 2018-03-23 16:08:30 no Contains ankyrin (ANK) repeats, one of the most common protein-protein interaction motifs in nature. 1 vladimir 0.263768 0.2551 0.26087 0.22029 0.515942 0.484058 0.191304 0.295652 0.33913 0.173913 0.634783 0.365217 0.4 0.234783 0.156522 0.208696 0.391304 0.608696 0.2 0.234783 0.286957 0.278261 0.521739 0.478261 0.578653 12978.895 -0.712281 0.263158 0.464912 0.149123 0.140351 0.517544 0.482456 0.298246 0.122807 0.175439 4.668465 10.675439 NMV_1258 2192220 fCDS -2 1268419 1268886 468 validated/Curated pseudo conserved hypothetical ANK repeat-containing protein (pseudogene part 1) 3 : Putative function from multiple computational evidences u : unknown 2 : Cytoplasmic 2018-03-23 16:08:16 no Contains ankyrin (ANK) repeats, one of the most common protein-protein interaction motifs in nature. 2 vladimir 0.248971 0.2325 0.277778 0.240741 0.510288 0.489712 0.234568 0.185185 0.395062 0.185185 0.580247 0.419753 0.333333 0.12963 0.234568 0.302469 0.364198 0.635802 0.179012 0.382716 0.203704 0.234568 0.58642 0.41358 0.740865 18702.37 -0.297516 0.223602 0.453416 0.198758 0.15528 0.590062 0.409938 0.279503 0.093168 0.186335 4.271126 10.621118 NMV_1259 2192221 CDS -3 1268925 1269581 657 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:08:50 no 1 vladimir 0.304414 0.2237 0.254186 0.217656 0.47793 0.52207 0.283105 0.16895 0.347032 0.200913 0.515982 0.484018 0.374429 0.173516 0.187215 0.26484 0.360731 0.639269 0.255708 0.328767 0.22831 0.187215 0.557078 0.442922 0.623408 24981.545 -0.613303 0.256881 0.412844 0.201835 0.123853 0.490826 0.509174 0.353211 0.201835 0.151376 9.200371 9.431193 NMV_1260 2192222 CDS -3 1269663 1271525 1863 validated/Curated no putative chaperone protein HscA 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2018-01-23 17:00:17 no Is a specialised bacterial Hsp70-class molecular chaperone that participates in the assembly of iron-sulphur cluster proteins. 2 vladimir 0.235105 0.3247 0.263017 0.177134 0.587762 0.412238 0.244767 0.241546 0.402576 0.111111 0.644122 0.355878 0.291465 0.259259 0.170692 0.278583 0.429952 0.570048 0.169082 0.47343 0.215781 0.141707 0.689211 0.310789 0.702103 66149.075 -0.12129 0.343548 0.554839 0.237097 0.058065 0.535484 0.464516 0.235484 0.11129 0.124194 5.126793 9.272581 NMV_1261 2192223 CDS +3 1271697 1272569 873 validated/Curated no putative phytoene synthase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.5.1.- 2.5.1.32-RXN$RXN-12245$RXNARA-8002 PWY-5942$PWY-6287 2018-01-23 17:01:45 no Catalyses the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. 2 vladimir 0.256586 0.2554 0.273769 0.214204 0.52921 0.47079 0.219931 0.237113 0.353952 0.189003 0.591065 0.408935 0.323024 0.199313 0.185567 0.292096 0.38488 0.61512 0.226804 0.329897 0.281787 0.161512 0.611684 0.388316 0.66228 32866.855 -0.23931 0.258621 0.465517 0.22069 0.096552 0.568966 0.431034 0.275862 0.148276 0.127586 8.682335 9.762069 NMV_1262 2192224 CDS +3 1272648 1273961 1314 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-23 17:02:27 no Shows similarity to various amine oxidases. 2 vladimir 0.179604 0.3584 0.283105 0.178843 0.641553 0.358447 0.16895 0.308219 0.376712 0.146119 0.684931 0.315068 0.23516 0.299087 0.189498 0.276256 0.488584 0.511416 0.134703 0.468037 0.283105 0.114155 0.751142 0.248858 0.638291 47190.56 -0.009382 0.322654 0.544622 0.237986 0.100686 0.620137 0.379863 0.224256 0.1373 0.086957 9.140022 9.475973 NMV_1263 2192225 CDS +2 1274045 1274764 720 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-06 12:59:35 no 2 vladimir 0.241667 0.3222 0.261111 0.175 0.583333 0.416667 0.220833 0.208333 0.404167 0.166667 0.6125 0.3875 0.295833 0.270833 0.179167 0.254167 0.45 0.55 0.208333 0.4875 0.2 0.104167 0.6875 0.3125 0.726462 25867.46 -0.042678 0.34728 0.523013 0.205021 0.125523 0.610879 0.389121 0.225941 0.117155 0.108787 5.998161 9.175732 NMV_1264 2192226 CDS +1 1274929 1275600 672 validated/Curated no putative CsgG-like lipoprotein 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 2018-01-23 17:03:24 no CsgG is required during curli assembly/transport, an adhesive surface fibre, to maintain the stability of the fiber subunits CsgA and CsgB. 1 vladimir 0.254464 0.2946 0.236607 0.214286 0.53125 0.46875 0.263393 0.174107 0.388393 0.174107 0.5625 0.4375 0.299107 0.25 0.183036 0.267857 0.433036 0.566964 0.200893 0.459821 0.138393 0.200893 0.598214 0.401786 0.738322 23737.58 -0.143049 0.367713 0.587444 0.233184 0.085202 0.524664 0.475336 0.201794 0.116592 0.085202 8.994225 9.192825 NMV_1265 2192227 CDS +1 1275610 1275978 369 validated/Curated no conserved hypothetical TPR-containing lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-23 17:03:48 no Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.268817 0.2339 0.290323 0.206989 0.524194 0.475806 0.258065 0.177419 0.354839 0.209677 0.532258 0.467742 0.346774 0.209677 0.201613 0.241935 0.41129 0.58871 0.201613 0.314516 0.314516 0.169355 0.629032 0.370968 0.655757 13495.9 -0.534959 0.333333 0.479675 0.146341 0.113821 0.552846 0.447154 0.276423 0.162602 0.113821 9.059486 9.504065 NMV_1266 2192228 CDS +3 1275975 1276622 648 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 12:58:49 no 2 vladimir 0.242284 0.2855 0.256173 0.216049 0.541667 0.458333 0.25463 0.180556 0.361111 0.203704 0.541667 0.458333 0.296296 0.287037 0.148148 0.268519 0.435185 0.564815 0.175926 0.388889 0.259259 0.175926 0.648148 0.351852 0.690752 22929.95 -0.054419 0.344186 0.590698 0.237209 0.093023 0.562791 0.437209 0.181395 0.093023 0.088372 5.936531 8.8 NMV_1267 2192229 CDS +1 1277065 1278207 1143 validated/Curated partial truncated putative ABC transporter ATP-binding protein (N-terminal 70% of the protein) 5 : Unknown function t : transporter 1 : Unknown 2018-01-23 17:04:25 no Is interrupted by a 28 kb phage. 2 vladimir 0.228346 0.2738 0.252843 0.244969 0.526684 0.473316 0.259843 0.230971 0.301837 0.207349 0.532808 0.467192 0.272966 0.194226 0.181102 0.351706 0.375328 0.624672 0.152231 0.396325 0.275591 0.175853 0.671916 0.328084 0.671312 43584.855 0.122105 0.260526 0.444737 0.252632 0.139474 0.584211 0.415789 0.205263 0.115789 0.089474 8.976067 9.423684 NMV_1268 2192230 CDS -1 1278317 1278526 210 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:58:26 no 1 vladimir 0.219048 0.2905 0.261905 0.228571 0.552381 0.447619 0.285714 0.242857 0.285714 0.185714 0.528571 0.471429 0.142857 0.3 0.214286 0.342857 0.514286 0.485714 0.228571 0.328571 0.285714 0.157143 0.614286 0.385714 0.618869 7714.67 0.273913 0.376812 0.521739 0.202899 0.130435 0.57971 0.42029 0.144928 0.072464 0.072464 5.986412 9.623188 NMV_1269 2192231 CDS -2 1278523 1278819 297 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:58:15 no 2 vladimir 0.262626 0.3098 0.26936 0.158249 0.579125 0.420875 0.262626 0.292929 0.292929 0.151515 0.585859 0.414141 0.343434 0.191919 0.242424 0.222222 0.434343 0.565657 0.181818 0.444444 0.272727 0.10101 0.717172 0.282828 0.563447 11323.545 -0.695918 0.295918 0.418367 0.173469 0.142857 0.489796 0.510204 0.316327 0.234694 0.081633 10.324242 9.704082 NMV_1270 2192232 CDS -3 1278798 1279403 606 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 17:05:01 no May be of phagic origin. 2 vladimir 0.262376 0.3003 0.285479 0.151815 0.585809 0.414191 0.232673 0.188119 0.450495 0.128713 0.638614 0.361386 0.331683 0.282178 0.158416 0.227723 0.440594 0.559406 0.222772 0.430693 0.247525 0.09901 0.678218 0.321782 0.668019 21755.67 -0.318408 0.328358 0.497512 0.19403 0.074627 0.572139 0.427861 0.273632 0.114428 0.159204 4.739174 9.671642 NMV_1271 2192233 CDS +1 1279483 1279770 288 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:57:53 no 1 vladimir 0.302083 0.2326 0.21875 0.246528 0.451389 0.548611 0.3125 0.21875 0.302083 0.166667 0.520833 0.479167 0.34375 0.197917 0.177083 0.28125 0.375 0.625 0.25 0.28125 0.177083 0.291667 0.458333 0.541667 0.578175 11186.5 -0.556842 0.2 0.442105 0.221053 0.115789 0.494737 0.505263 0.326316 0.2 0.126316 9.717552 9.957895 NMV_1272 2192234 CDS +2 1279742 1280044 303 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:09:40 no 1 vladimir 0.280899 0.2809 0.254682 0.183521 0.535581 0.464419 0.202247 0.269663 0.393258 0.134831 0.662921 0.337079 0.359551 0.213483 0.146067 0.280899 0.359551 0.640449 0.280899 0.359551 0.224719 0.134831 0.58427 0.41573 0.659808 9943.095 -0.443182 0.238636 0.431818 0.238636 0.068182 0.511364 0.488636 0.306818 0.181818 0.125 9.692986 9.522727 NMV_1273 2192235 CDS -3 1280646 1281017 372 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:57:31 no 3 vladimir 0.303763 0.0780 0.362903 0.255376 0.44086 0.55914 0.25 0 0.725806 0.024194 0.725806 0.274194 0.25 0.233871 0.032258 0.483871 0.266129 0.733871 0.41129 0 0.330645 0.258065 0.330645 0.669355 0.348611 12856.72 1.476423 0.260163 0.504065 0.414634 0 0.747967 0.252033 0.252033 0.00813 0.243902 3.205681 11.073171 NMV_1274 2192236 CDS -2 1281055 1282956 1902 validated/Curated no putative phage tail fibre protein 3 : Putative function from multiple computational evidences s : structure 1 : Unknown 2008-05-06 12:57:21 no 2 vladimir 0.270768 0.3396 0.240799 0.148791 0.580442 0.419558 0.285489 0.225552 0.342271 0.146688 0.567823 0.432177 0.324921 0.260252 0.197161 0.217666 0.457413 0.542587 0.201893 0.533123 0.182965 0.082019 0.716088 0.283912 0.694638 69447.4 -0.530332 0.328594 0.557662 0.178515 0.115324 0.508689 0.491311 0.241706 0.132701 0.109005 6.355019 9.486572 NMV_1275 2192237 CDS -1 1282967 1283527 561 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:57:08 no 2 vladimir 0.194296 0.3030 0.317291 0.185383 0.620321 0.379679 0.203209 0.256684 0.406417 0.13369 0.663102 0.336898 0.262032 0.240642 0.240642 0.256684 0.481283 0.518717 0.117647 0.411765 0.304813 0.165775 0.716578 0.283422 0.670257 20490.435 -0.287097 0.306452 0.537634 0.209677 0.086022 0.580645 0.419355 0.247312 0.139785 0.107527 9.678673 10.301075 NMV_1276 2192238 CDS -2 1283524 1284033 510 validated/Curated partial truncated putative baseplate J-like phage protein (C-terminal half of the protein) 5 : Unknown function s : structure 1 : Unknown 2018-01-23 17:07:21 no The P2 bacteriophage J protein lies at the edge of the baseplate. 1 vladimir 0.226519 0.2836 0.294659 0.195212 0.578269 0.421731 0.281768 0.20442 0.39779 0.116022 0.60221 0.39779 0.254144 0.287293 0.18232 0.276243 0.469613 0.530387 0.143646 0.359116 0.303867 0.19337 0.662983 0.337017 0.628855 19563.615 -0.097222 0.311111 0.6 0.255556 0.055556 0.566667 0.433333 0.238889 0.122222 0.116667 7.770058 9.95 NMV_1277 2192239 CDS -1 1284026 1284226 201 validated/Curated partial truncated conserved hypothetical phage protein (N-terminal 30% of the protein) 5 : Unknown function u : unknown 1 : Unknown 2018-01-23 17:07:47 no 1 vladimir 0.269231 0.2735 0.277778 0.179487 0.551282 0.448718 0.269231 0.294872 0.282051 0.153846 0.576923 0.423077 0.294872 0.25641 0.192308 0.25641 0.448718 0.551282 0.24359 0.269231 0.358974 0.128205 0.628205 0.371795 0.54857 8569.57 -0.453247 0.311688 0.441558 0.220779 0.064935 0.480519 0.519481 0.272727 0.181818 0.090909 10.26133 8.883117 NMV_1278 2192240 CDS -2 1284223 1285368 1146 validated/Curated no putative phage tail protein 3 : Putative function from multiple computational evidences s : structure 1 : Unknown 2008-05-06 12:56:37 no 1 vladimir 0.239965 0.2557 0.32548 0.178883 0.581152 0.418848 0.26178 0.206806 0.384817 0.146597 0.591623 0.408377 0.316754 0.196335 0.232984 0.253927 0.429319 0.570681 0.141361 0.363874 0.358639 0.136126 0.722513 0.277487 0.62972 42151.13 -0.471916 0.293963 0.52231 0.207349 0.099738 0.52231 0.47769 0.304462 0.170604 0.133858 8.324089 9.220472 NMV_1279 2192241 CDS -1 1285358 1285828 471 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 17:08:20 no Contains a domain found in a number of phage DNA circulation proteins. 1 vladimir 0.205945 0.3057 0.303609 0.184713 0.609342 0.390658 0.210191 0.261146 0.401274 0.127389 0.66242 0.33758 0.261146 0.33758 0.127389 0.273885 0.464968 0.535032 0.146497 0.318471 0.382166 0.152866 0.700637 0.299363 0.602914 16719.565 0.086538 0.346154 0.525641 0.24359 0.076923 0.589744 0.410256 0.217949 0.134615 0.083333 9.222908 9.884615 NMV_1280 2192242 CDS -3 1285929 1286990 1062 validated/Curated no putative phage maturation peptidase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-23 17:08:48 no Belongs to MEROPS peptidase family U35 (clan U-). Is a peptidase predicted to be involved in Mu phage/prophage I head maturation. 1 vladimir 0.268362 0.2505 0.29096 0.190207 0.541431 0.458569 0.223164 0.194915 0.426554 0.155367 0.621469 0.378531 0.333333 0.29661 0.121469 0.248588 0.418079 0.581921 0.248588 0.259887 0.324859 0.166667 0.584746 0.415254 0.684526 37998.74 -0.207649 0.331445 0.515581 0.195467 0.082153 0.572238 0.427762 0.249292 0.113314 0.135977 5.024147 9.076487 NMV_1281 2192243 CDS -1 1287221 1287637 417 validated/Curated no putative phage tail completion protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-23 17:09:00 no Homologous to protein S of phage P2, suggested experimentally to act in tail completion and stable head joining, and related proteins from a number of phages. 1 vladimir 0.2494 0.2614 0.263789 0.22542 0.52518 0.47482 0.280576 0.251799 0.309353 0.158273 0.561151 0.438849 0.323741 0.172662 0.18705 0.316547 0.359712 0.640288 0.143885 0.359712 0.294964 0.201439 0.654676 0.345324 0.558614 15737.415 -0.373188 0.231884 0.478261 0.23913 0.101449 0.521739 0.478261 0.282609 0.15942 0.123188 9.28112 9.485507 NMV_1282 2192244 CDS -3 1287765 1289090 1326 validated/Curated no putative phage head morphogenesis protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-23 17:09:15 no Contains a domain found exclusively in phage-related proteins, internally or toward the C terminus. One member, gp7 of phage SPP1, appears to be involved in head morphogenesis. 1 vladimir 0.294872 0.2149 0.266214 0.223982 0.481146 0.518854 0.29638 0.192308 0.323529 0.187783 0.515837 0.484163 0.377828 0.201357 0.180995 0.239819 0.382353 0.617647 0.210407 0.251131 0.294118 0.244344 0.545249 0.454751 0.567981 50511.35 -0.673016 0.263039 0.46712 0.172336 0.126984 0.510204 0.489796 0.301587 0.163265 0.138322 8.728905 9.555556 NMV_1283 2192245 CDS -2 1289077 1290645 1569 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 17:09:29 no Homologous to the bacteriophage Mu gp29 protein. 1 vladimir 0.253665 0.2792 0.280433 0.186743 0.559592 0.440408 0.256214 0.246654 0.365201 0.131931 0.611855 0.388145 0.330784 0.244742 0.154876 0.269598 0.399618 0.600382 0.173996 0.34608 0.321224 0.1587 0.667304 0.332696 0.643904 58073.485 -0.351533 0.272031 0.503831 0.206897 0.097701 0.538314 0.461686 0.264368 0.128352 0.136015 5.295021 9.6341 NMV_1284 2192246 CDS -3 1290645 1292267 1623 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:10:10 no Contains a domain found in the C-terminal region of a set of phage proteins. 1 vladimir 0.23968 0.2397 0.293284 0.227357 0.532964 0.467036 0.238447 0.23475 0.358595 0.168207 0.593346 0.406654 0.332717 0.203327 0.18854 0.275416 0.391867 0.608133 0.147874 0.280961 0.332717 0.238447 0.613678 0.386322 0.619112 61280.515 -0.402593 0.248148 0.481481 0.211111 0.12037 0.544444 0.455556 0.288889 0.151852 0.137037 6.367729 9.490741 NMV_1285 2192247 CDS +2 1292279 1292791 513 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:10:34 no 3 vladimir 0.321637 0.1774 0.220273 0.280702 0.397661 0.602339 0.25731 0.169591 0.321637 0.251462 0.491228 0.508772 0.356725 0.210526 0.163743 0.269006 0.374269 0.625731 0.350877 0.152047 0.175439 0.321637 0.327485 0.672515 0.515144 19070.905 -0.278824 0.311765 0.441176 0.211765 0.117647 0.523529 0.476471 0.241176 0.117647 0.123529 5.49572 9.241176 NMV_1286 2192248 CDS -1 1292759 1293292 534 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:10:55 no 1 vladimir 0.2397 0.2341 0.303371 0.222846 0.537453 0.462547 0.264045 0.179775 0.370787 0.185393 0.550562 0.449438 0.269663 0.269663 0.191011 0.269663 0.460674 0.539326 0.185393 0.252809 0.348315 0.213483 0.601124 0.398876 0.649011 19460.63 -0.173446 0.338983 0.497175 0.19209 0.084746 0.559322 0.440678 0.254237 0.124294 0.129944 5.430138 9.525424 NMV_1287 2192249 CDS -2 1293295 1293492 198 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:54:22 no 2 vladimir 0.323232 0.2172 0.282828 0.176768 0.5 0.5 0.363636 0.19697 0.348485 0.090909 0.545455 0.454545 0.333333 0.212121 0.166667 0.287879 0.378788 0.621212 0.272727 0.242424 0.333333 0.151515 0.575758 0.424242 0.678771 7142.02 -0.249231 0.307692 0.430769 0.230769 0.030769 0.523077 0.476923 0.261538 0.138462 0.123077 8.336372 9.138462 NMV_1288 2192250 CDS -3 1293489 1293755 267 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:11:12 no 2 vladimir 0.310861 0.2172 0.277154 0.194757 0.494382 0.505618 0.292135 0.168539 0.359551 0.179775 0.52809 0.47191 0.404494 0.202247 0.146067 0.247191 0.348315 0.651685 0.235955 0.280899 0.325843 0.157303 0.606742 0.393258 0.636643 10293.295 -0.75 0.227273 0.409091 0.181818 0.125 0.454545 0.545455 0.397727 0.215909 0.181818 7.96125 8.886364 NMV_1289 2192251 CDS -1 1293767 1294108 342 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:11:34 no 1 vladimir 0.219298 0.2164 0.280702 0.283626 0.497076 0.502924 0.210526 0.201754 0.377193 0.210526 0.578947 0.421053 0.333333 0.192982 0.192982 0.280702 0.385965 0.614035 0.114035 0.254386 0.27193 0.359649 0.526316 0.473684 0.654387 12922.14 -0.253097 0.265487 0.522124 0.221239 0.141593 0.557522 0.442478 0.274336 0.132743 0.141593 5.238731 10.557522 NMV_1290 2192252 CDS -2 1294105 1294299 195 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:53:50 no 2 vladimir 0.225641 0.2615 0.34359 0.169231 0.605128 0.394872 0.184615 0.230769 0.446154 0.138462 0.676923 0.323077 0.292308 0.323077 0.184615 0.2 0.507692 0.492308 0.2 0.230769 0.4 0.169231 0.630769 0.369231 0.673343 6857.365 -0.5 0.3125 0.625 0.15625 0.078125 0.59375 0.40625 0.21875 0.09375 0.125 4.796104 10.515625 NMV_1291 2192253 CDS -1 1294319 1294573 255 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:53:40 no 1 vladimir 0.301961 0.2353 0.278431 0.184314 0.513726 0.486275 0.247059 0.2 0.411765 0.141176 0.611765 0.388235 0.435294 0.188235 0.188235 0.188235 0.376471 0.623529 0.223529 0.317647 0.235294 0.223529 0.552941 0.447059 0.672966 9221.035 -0.779762 0.321429 0.452381 0.166667 0.083333 0.5 0.5 0.321429 0.202381 0.119048 9.479576 9.809524 NMV_1292 2192254 CDS -3 1294644 1294808 165 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:53:30 no 1 vladimir 0.290909 0.1818 0.333333 0.193939 0.515152 0.484848 0.236364 0.2 0.4 0.163636 0.6 0.4 0.4 0.181818 0.163636 0.254545 0.345455 0.654545 0.236364 0.163636 0.436364 0.163636 0.6 0.4 0.593799 6168.735 -0.462963 0.296296 0.37037 0.148148 0.12963 0.518519 0.481481 0.296296 0.12963 0.166667 4.946068 9.722222 NMV_1294 2192256 CDS -2 1295014 1295556 543 validated/Curated no putative amidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic AMIDASE-RXN$NICOTINAMID-RXN$R311-RXN P344-PWY$PYRIDNUCSAL-PWY 2018-01-23 17:11:17 no Shows some homologies with the N-acetylmuramoyl-L-alanine amidase 3 family that hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. 1 vladimir 0.244936 0.2541 0.303867 0.197053 0.558011 0.441989 0.325967 0.149171 0.39779 0.127072 0.546961 0.453039 0.281768 0.243094 0.226519 0.248619 0.469613 0.530387 0.127072 0.370166 0.287293 0.21547 0.657459 0.342541 0.722506 19212.115 -0.178333 0.372222 0.572222 0.2 0.077778 0.55 0.45 0.261111 0.155556 0.105556 9.195992 9.238889 NMV_1295 2192257 CDS -1 1295699 1296175 477 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2015-11-21 12:44:18 no 3 vladimir 0.335249 0.1609 0.247126 0.256705 0.408046 0.591954 0.252874 0.178161 0.362069 0.206897 0.54023 0.45977 0.436782 0.183908 0.155172 0.224138 0.33908 0.66092 0.316092 0.12069 0.224138 0.33908 0.344828 0.655172 0.590136 19880.59 -0.701156 0.271676 0.433526 0.132948 0.138728 0.508671 0.491329 0.294798 0.144509 0.150289 5.524773 10.104046 NMV_1296 2192258 CDS -3 1296222 1296662 441 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-21 10:18:56 no 1 vladimir 0.222973 0.2185 0.317568 0.240991 0.536036 0.463964 0.236486 0.236486 0.358108 0.168919 0.594595 0.405405 0.317568 0.209459 0.195946 0.277027 0.405405 0.594595 0.114865 0.209459 0.398649 0.277027 0.608108 0.391892 0.532075 16572.29 -0.265986 0.285714 0.462585 0.22449 0.102041 0.544218 0.455782 0.265306 0.136054 0.129252 5.949562 10.14966 NMV_1297 2192259 CDS -1 1296662 1297063 402 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:52:41 no 1 vladimir 0.233831 0.2214 0.340796 0.20398 0.562189 0.437811 0.283582 0.231343 0.343284 0.141791 0.574627 0.425373 0.30597 0.216418 0.231343 0.246269 0.447761 0.552239 0.11194 0.216418 0.447761 0.223881 0.664179 0.335821 0.62362 15157.06 -0.592481 0.278195 0.458647 0.195489 0.075188 0.503759 0.496241 0.345865 0.233083 0.112782 10.278099 10.022556 NMV_1298 2192260 CDS -1 1297262 1298149 888 validated/Curated no putative RdgC-like protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 17:12:36 no RdgC is required for efficient pilin variation in N. gonorrhoeae, suggesting that it may be involved in recombination reactions. May have exonuclease activity. 1 vladimir 0.272523 0.2162 0.26464 0.246622 0.480856 0.519144 0.246622 0.226351 0.358108 0.168919 0.584459 0.415541 0.307432 0.199324 0.185811 0.307432 0.385135 0.614865 0.263514 0.222973 0.25 0.263514 0.472973 0.527027 0.621041 33065.7 -0.198644 0.267797 0.454237 0.247458 0.084746 0.538983 0.461017 0.267797 0.125424 0.142373 5.153816 8.966102 NMV_1299 2192261 CDS -2 1298194 1298385 192 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:52:09 no 1 vladimir 0.333333 0.1667 0.291667 0.208333 0.458333 0.541667 0.4375 0.09375 0.359375 0.109375 0.453125 0.546875 0.359375 0.203125 0.125 0.3125 0.328125 0.671875 0.203125 0.203125 0.390625 0.203125 0.59375 0.40625 0.61095 6947.77 -0.18254 0.269841 0.492063 0.222222 0.047619 0.539683 0.460317 0.253968 0.111111 0.142857 4.854637 9.634921 NMV_1300 2192262 CDS -3 1298385 1298906 522 validated/Curated no gam host-nuclease inhibitor phage protein Gam 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2018-01-23 17:13:21 no The gam gene of bacteriophage Mu encodes a protein with DNA-binding characteristics, which protects linear double stranded DNA from exonuclease degradation in vitro and in vivo. 1 vladimir 0.295019 0.2586 0.268199 0.178161 0.52682 0.47318 0.281609 0.178161 0.41954 0.12069 0.597701 0.402299 0.344828 0.270115 0.132184 0.252874 0.402299 0.597701 0.258621 0.327586 0.252874 0.16092 0.58046 0.41954 0.679753 19224.28 -0.377457 0.300578 0.468208 0.202312 0.063584 0.50289 0.49711 0.32948 0.156069 0.17341 5.287651 9.462428 NMV_1301 2192263 CDS -1 1298921 1299148 228 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:51:35 no 3 vladimir 0.372807 0.1667 0.188596 0.27193 0.355263 0.644737 0.381579 0.157895 0.302632 0.157895 0.460526 0.539474 0.394737 0.157895 0.105263 0.342105 0.263158 0.736842 0.342105 0.184211 0.157895 0.315789 0.342105 0.657895 0.589893 8588.68 -0.198667 0.2 0.4 0.253333 0.08 0.52 0.48 0.28 0.146667 0.133333 8.216316 8.773333 NMV_1302 2192264 CDS -1 1299212 1299379 168 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:12:03 no 1 vladimir 0.27381 0.1607 0.363095 0.202381 0.52381 0.47619 0.267857 0.107143 0.482143 0.142857 0.589286 0.410714 0.339286 0.196429 0.178571 0.285714 0.375 0.625 0.214286 0.178571 0.428571 0.178571 0.607143 0.392857 0.557707 6266.92 -0.309091 0.254545 0.418182 0.2 0.072727 0.563636 0.436364 0.345455 0.109091 0.236364 4.281166 10.345455 NMV_1303 2192265 CDS -3 1299372 1299545 174 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:51:13 no 1 vladimir 0.333333 0.1839 0.344828 0.137931 0.528736 0.471264 0.275862 0.258621 0.362069 0.103448 0.62069 0.37931 0.431034 0.137931 0.327586 0.103448 0.465517 0.534483 0.293103 0.155172 0.344828 0.206897 0.5 0.5 0.50087 6871.28 -1.9 0.263158 0.368421 0.035088 0.105263 0.333333 0.666667 0.45614 0.263158 0.192982 9.688072 11.315789 NMV_1304 2192266 CDS -1 1299542 1299661 120 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:51:02 no 1 vladimir 0.333333 0.1250 0.316667 0.225 0.441667 0.558333 0.35 0.1 0.4 0.15 0.5 0.5 0.375 0.2 0.175 0.25 0.375 0.625 0.275 0.075 0.375 0.275 0.45 0.55 0.534116 4268.93 -0.374359 0.25641 0.487179 0.230769 0.025641 0.564103 0.435897 0.384615 0.25641 0.128205 9.731544 8.666667 NMV_1305 2192267 CDS -3 1299654 1299920 267 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:50:51 no 1 vladimir 0.254682 0.1311 0.370787 0.243446 0.501873 0.498127 0.235955 0.11236 0.426966 0.224719 0.539326 0.460674 0.337079 0.168539 0.179775 0.314607 0.348315 0.651685 0.191011 0.11236 0.505618 0.191011 0.617978 0.382022 0.589469 10213.605 -0.163636 0.227273 0.431818 0.215909 0.113636 0.579545 0.420455 0.318182 0.159091 0.159091 5.881737 10.215909 NMV_1307 2192269 CDS -3 1300011 1300925 915 validated/Curated no putative phage transposition protein 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-23 17:14:24 no This protein in bacteriophage Mu is a non-specific DNA-binding and ATP-hydrolysing protein, essential for bacteriophage integration and replication. 1 vladimir 0.256831 0.2230 0.300546 0.219672 0.523497 0.476503 0.285246 0.206557 0.363934 0.144262 0.570492 0.429508 0.314754 0.209836 0.180328 0.295082 0.390164 0.609836 0.170492 0.252459 0.357377 0.219672 0.609836 0.390164 0.669914 33301.045 -0.228618 0.299342 0.480263 0.240132 0.055921 0.529605 0.470395 0.266447 0.148026 0.118421 9.067604 9.460526 NMV_1308 2192270 CDS -1 1300961 1302937 1977 validated/Curated no putative phage transposase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-23 17:14:48 no This transposase in bacteriophage Mu is essential for integration, replication-transposition, and excision of phage DNA. 1 vladimir 0.250885 0.2129 0.328275 0.207891 0.541224 0.458776 0.271624 0.201821 0.371775 0.15478 0.573596 0.426404 0.327769 0.227618 0.192716 0.251897 0.420334 0.579666 0.153263 0.209408 0.420334 0.216995 0.629742 0.370258 0.555937 73449.035 -0.456383 0.287234 0.490881 0.18997 0.101824 0.544073 0.455927 0.287234 0.162614 0.12462 9.118019 9.731003 NMV_1309 2192271 CDS -3 1302939 1303190 252 validated/Curated no putative DNA-binding phage protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-03-23 16:12:42 no 3 vladimir 0.384921 0.1349 0.246032 0.234127 0.380952 0.619048 0.357143 0.095238 0.369048 0.178571 0.464286 0.535714 0.369048 0.190476 0.154762 0.285714 0.345238 0.654762 0.428571 0.119048 0.214286 0.238095 0.333333 0.666667 0.457515 9247.36 -0.373494 0.26506 0.445783 0.240964 0.048193 0.493976 0.506024 0.325301 0.192771 0.13253 9.374687 9.253012 NMV_1310 2192272 CDS +2 1303238 1304137 900 validated/Curated no putative DNA-binding protein 3 : Putative function from multiple computational evidences r : regulator 1 : Unknown 2020-04-23 18:49:52 no Contains a cro/C1-type HTH domain, which is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. 3 vladimir 0.346667 0.1833 0.205556 0.264444 0.388889 0.611111 0.33 0.16 0.31 0.2 0.47 0.53 0.38 0.2 0.143333 0.276667 0.343333 0.656667 0.33 0.19 0.163333 0.316667 0.353333 0.646667 0.52392 33853.32 -0.351171 0.264214 0.478261 0.244147 0.100334 0.488294 0.511706 0.267559 0.153846 0.113712 9.077858 8.795987 NMV_1312 2192274 CDS +1 1304347 1304517 171 validated/Curated partial truncated putative transcriptional regulator (C-terminal 22% of the protein) 5 : Unknown function r : regulator 2 : Cytoplasmic 2008-05-06 12:49:51 no 3 vladimir 0.280702 0.2105 0.239766 0.269006 0.450292 0.549708 0.280702 0.245614 0.315789 0.157895 0.561403 0.438596 0.315789 0.140351 0.22807 0.315789 0.368421 0.631579 0.245614 0.245614 0.175439 0.333333 0.421053 0.578947 0.554196 6459.135 -0.3125 0.196429 0.464286 0.285714 0.089286 0.535714 0.464286 0.285714 0.142857 0.142857 6.33889 9.482143 NMV_1313 2192275 CDS -2 1304560 1305525 966 validated/Curated no IS1655 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-23 17:15:36 no Belongs to the IS30 family. 2 vladimir 0.321946 0.3085 0.207039 0.162526 0.515528 0.484472 0.34472 0.298137 0.214286 0.142857 0.512422 0.487578 0.378882 0.173913 0.229814 0.217391 0.403727 0.596273 0.242236 0.453416 0.177019 0.127329 0.630435 0.369565 0.56472 38114.22 -0.941745 0.246106 0.389408 0.193146 0.130841 0.41433 0.58567 0.333333 0.242991 0.090343 10.266029 9.794393 NMV_1315 2192277 CDS +2 1305848 1306399 552 validated/Curated partial truncated putative ABC transporter ATP-binding protein (C-terminal 30% of the protein) 5 : Unknown function t : transporter 1 : Unknown 2018-01-23 17:15:51 no Is interrupted by a 28 kb phage. 2 vladimir 0.226449 0.3514 0.251812 0.17029 0.603261 0.396739 0.255435 0.309783 0.298913 0.13587 0.608696 0.391304 0.293478 0.211957 0.217391 0.277174 0.429348 0.570652 0.130435 0.532609 0.23913 0.097826 0.771739 0.228261 0.713552 20028.27 -0.206557 0.289617 0.508197 0.245902 0.087432 0.562842 0.437158 0.251366 0.147541 0.103825 8.385506 8.715847 NMV_1316 2192278 CDS +1 1306504 1307172 669 validated/Curated no hda DnaA regulatory inactivator Hda 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.1 : DNA replication ; 2018-01-31 20:37:22 no Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (DnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. 2 vladimir 0.252616 0.2975 0.248132 0.201794 0.54559 0.45441 0.219731 0.264574 0.35426 0.161435 0.618834 0.381166 0.349776 0.192825 0.143498 0.313901 0.336323 0.663677 0.188341 0.434978 0.246637 0.130045 0.681614 0.318386 0.656763 25394.115 -0.163964 0.247748 0.423423 0.22973 0.130631 0.558559 0.441441 0.261261 0.121622 0.13964 5.068687 9.540541 NMV_1317 2192279 CDS +3 1307169 1307837 669 validated/Curated no hisK histidinol-phosphatase 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 3.1.3.15 HISTIDPHOS-RXN HISTSYN-PWY HISTIDPHOS-RXN ; 2021-11-14 17:29:15 no 33139723 Is a previously unknown histidinol-phosphatase. Catalyses the following reaction: L-histidinol-phosphate + H2O <=> histidinol + phosphate. 1 david 0.285501 0.3333 0.201794 0.179372 0.535127 0.464873 0.295964 0.246637 0.304933 0.152466 0.55157 0.44843 0.372197 0.201794 0.147982 0.278027 0.349776 0.650224 0.188341 0.55157 0.152466 0.107623 0.704036 0.295964 0.739003 25325.755 -0.404505 0.252252 0.445946 0.211712 0.130631 0.518018 0.481982 0.27027 0.126126 0.144144 5.086845 9.315315 NMV_1318 2192280 CDS +1 1308301 1308744 444 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-06 12:48:45 no 3 vladimir 0.315315 0.1149 0.087838 0.481982 0.202703 0.797297 0.385135 0.087838 0.087838 0.439189 0.175676 0.824324 0.25 0.155405 0.067568 0.527027 0.222973 0.777027 0.310811 0.101351 0.108108 0.47973 0.209459 0.790541 0.440907 17733.9 1.058503 0.176871 0.312925 0.346939 0.244898 0.673469 0.326531 0.115646 0.081633 0.034014 9.208382 7.360544 NMV_1319 2192281 CDS -1 1309694 1310590 897 validated/Curated no argB acetylglutamate kinase (NAG kinase; AGK; N-acetyl-L-glutamate 5-phosphotransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 2.7.2.8 ACETYLGLUTKIN-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$GLUTORN-PWY 2018-01-23 17:18:49 no Catalyses the following reaction: ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamate 5-phosphate. 1 vladimir 0.247492 0.2375 0.303233 0.211817 0.540691 0.459309 0.297659 0.147157 0.451505 0.103679 0.598662 0.401338 0.287625 0.197324 0.173913 0.341137 0.371237 0.628763 0.157191 0.367893 0.284281 0.190635 0.652174 0.347826 0.66145 31281.955 0.190604 0.305369 0.533557 0.281879 0.053691 0.620805 0.379195 0.248322 0.120805 0.127517 5.360603 9.244966 NMV_1320 2192282 CDS +3 1310760 1311890 1131 validated/Curated no putative carboxypeptidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 17:46:05 no Belongs to MEROPS peptidase family M14 (carboxypeptidase A, clan MC), subfamilies M14A and M14B. 2 vladimir 0.236958 0.3050 0.255526 0.202476 0.560566 0.439434 0.233422 0.225464 0.350133 0.190981 0.575597 0.424403 0.320955 0.228117 0.188329 0.262599 0.416446 0.583554 0.156499 0.461538 0.228117 0.153846 0.689655 0.310345 0.713406 42088.375 -0.361702 0.281915 0.534574 0.196809 0.125 0.555851 0.444149 0.226064 0.093085 0.132979 4.614632 9.954787 NMV_1321 2192283 CDS +1 1311961 1312812 852 validated/Curated no lgt phosphatidylglycerol-prolipoprotein diacylglyceryl transferase 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.10 : Lipoprotein ; 2.5.1.145 RXN0-20 2020-04-21 15:49:00 no Catalyses the first step in lipoprotein biogenesis, the transfer of an sn-1,2-diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine of a prolipoprotein. 2 vladimir 0.183099 0.2829 0.265258 0.268779 0.548122 0.451878 0.190141 0.260563 0.320423 0.228873 0.580986 0.419014 0.211268 0.176056 0.225352 0.387324 0.401408 0.598592 0.147887 0.411972 0.25 0.190141 0.661972 0.338028 0.620055 31816.18 0.44523 0.268551 0.427562 0.272085 0.183746 0.70318 0.29682 0.169611 0.106007 0.063604 9.324272 8.727915 NMV_1322 2192284 CDS -1 1312895 1313557 663 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:13:20 no 2 vladimir 0.269985 0.2232 0.292609 0.214178 0.515837 0.484163 0.239819 0.158371 0.380091 0.221719 0.538462 0.461538 0.352941 0.21267 0.199095 0.235294 0.411765 0.588235 0.217195 0.298643 0.298643 0.18552 0.597285 0.402715 0.69487 24956.055 -0.537727 0.290909 0.477273 0.168182 0.104545 0.531818 0.468182 0.295455 0.1 0.195455 4.320686 10.209091 NMV_1323 2192285 CDS -1 1313807 1315600 1794 validated/Curated no leuA 2-isopropylmalate synthase (alpha-isopropylmalate synthase; alpha-IPM synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.19 : Leucine ; 2.3.3.13 2-ISOPROPYLMALATESYN-RXN LEUSYN-PWY 2018-01-23 17:47:29 no Catalyses the first step in the biosynthesis of leucine: acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O <=> (2S)-2-isopropylmalate + CoA. 1 vladimir 0.252252 0.2812 0.276705 0.189833 0.557915 0.442085 0.285714 0.150579 0.411197 0.15251 0.561776 0.438224 0.301158 0.27027 0.167954 0.260618 0.438224 0.561776 0.169884 0.42278 0.250965 0.156371 0.673745 0.326255 0.757933 55394.59 -0.170986 0.357834 0.535783 0.210832 0.073501 0.528046 0.471954 0.266925 0.133462 0.133462 5.685951 9.147002 NMV_1324 2192286 CDS +1 1315846 1316955 1110 validated/Curated no proB glutamate 5-kinase (gamma-glutamyl kinase; GK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.4 : Proline ; 2.7.2.11 GLUTKIN-RXN$PROLINE-MULTI PROSYN-PWY 2018-01-23 17:47:57 no Catalyses the first step in proline biosynthesis: ATP + L-glutamate <=> ADP + L-glutamate 5-phosphate. 1 vladimir 0.241441 0.2865 0.276577 0.195496 0.563063 0.436937 0.251351 0.213514 0.383784 0.151351 0.597297 0.402703 0.286486 0.256757 0.172973 0.283784 0.42973 0.57027 0.186486 0.389189 0.272973 0.151351 0.662162 0.337838 0.638595 39427.35 -0.060705 0.352304 0.523035 0.235772 0.084011 0.550136 0.449864 0.246612 0.138211 0.108401 7.962852 8.650407 NMV_1325 2192287 CDS +1 1316968 1318230 1263 validated/Curated no proA gamma-glutamyl phosphate reductase (GPR; glutamate-5-semialdehyde dehydrogenase; glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.4 : Proline ; 1.2.1.41 GLUTSEMIALDEHYDROG-RXN$PROLINE-MULTI PROSYN-PWY 2018-01-23 17:48:26 no Catalyses the second step in the biosynthesis of proline: L-glutamate 5-semialdehyde + phosphate + NADP(+) <=> L-glutamyl 5-phosphate + NADPH. 1 vladimir 0.239113 0.2795 0.297704 0.18369 0.577197 0.422803 0.249406 0.194774 0.437055 0.118765 0.631829 0.368171 0.289786 0.261283 0.171021 0.27791 0.432304 0.567696 0.178147 0.382423 0.285036 0.154394 0.667458 0.332542 0.651963 45010.495 -0.065238 0.335714 0.542857 0.233333 0.071429 0.569048 0.430952 0.27619 0.135714 0.140476 5.405998 9.509524 NMV_1326 2192288 CDS -3 1318455 1321493 3039 validated/Curated no putative FtsK-like protein 3 : Putative function from multiple computational evidences f : factor 5 : Inner membrane protein 2020-02-22 16:52:59 no Contains a FtsK domain 1 vladimir 0.240869 0.2659 0.282659 0.210596 0.548536 0.451464 0.232971 0.219151 0.408687 0.139191 0.627838 0.372162 0.305035 0.269497 0.153998 0.271471 0.423495 0.576505 0.1846 0.308983 0.285291 0.221125 0.594274 0.405726 0.66974 110951.095 -0.304447 0.288538 0.531621 0.210474 0.077075 0.541502 0.458498 0.278656 0.114625 0.164032 4.680962 9.745059 NMV_1327 2192289 CDS +2 1321658 1322338 681 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 12:46:20 no 2 vladimir 0.143906 0.3172 0.251101 0.287812 0.568282 0.431718 0.202643 0.264317 0.303965 0.229075 0.568282 0.431718 0.136564 0.312775 0.145374 0.405286 0.45815 0.54185 0.092511 0.374449 0.303965 0.229075 0.678414 0.321586 0.644544 24491.215 1.006195 0.336283 0.522124 0.314159 0.132743 0.734513 0.265487 0.088496 0.057522 0.030973 9.256874 8.415929 NMV_1328 2192290 CDS +3 1322367 1322726 360 validated/Curated no putative fluoride ion transporter CrcB 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-23 18:03:37 no Important for reducing fluoride concentration in the cell, thus reducing its toxicity. 2 vladimir 0.188889 0.3361 0.233333 0.241667 0.569444 0.430556 0.283333 0.3 0.258333 0.158333 0.558333 0.441667 0.141667 0.341667 0.15 0.366667 0.491667 0.508333 0.141667 0.366667 0.291667 0.2 0.658333 0.341667 0.531841 12453.21 0.797479 0.403361 0.529412 0.310924 0.092437 0.663866 0.336134 0.07563 0.058824 0.016807 10.278099 7.588235 NMV_1329 2192291 CDS -2 1322989 1323288 300 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:13:50 no 3 vladimir 0.406667 0.0867 0.17 0.336667 0.256667 0.743333 0.29 0.1 0.34 0.27 0.44 0.56 0.47 0.08 0.14 0.31 0.22 0.78 0.46 0.08 0.03 0.43 0.11 0.89 0.457122 11765.77 -0.390909 0.161616 0.373737 0.242424 0.171717 0.545455 0.454545 0.292929 0.10101 0.191919 4.362877 10.030303 NMV_1330 2192292 CDS -3 1323429 1323593 165 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:45:43 no 3 vladimir 0.248485 0.1212 0.169697 0.460606 0.290909 0.709091 0.309091 0.090909 0.236364 0.363636 0.327273 0.672727 0.236364 0.181818 0.090909 0.490909 0.272727 0.727273 0.2 0.090909 0.181818 0.527273 0.272727 0.727273 0.543912 6458.335 0.572222 0.203704 0.425926 0.240741 0.222222 0.592593 0.407407 0.222222 0.092593 0.12963 4.531746 8.648148 NMV_1331 2192293 CDS -1 1323770 1324306 537 validated/Curated no putative ADP-ribose pyrophosphatase NudF 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.6.1.13 RXN0-1441 2018-01-23 18:06:27 no Catalyses the following reaction: ADP-ribose + H(2)O <=> AMP + D-ribose 5-phosphate. 1 vladimir 0.264432 0.1899 0.320298 0.225326 0.510242 0.489758 0.256983 0.145251 0.430168 0.167598 0.575419 0.424581 0.329609 0.184358 0.201117 0.284916 0.385475 0.614525 0.206704 0.240223 0.329609 0.223464 0.569832 0.430168 0.608135 19738.675 -0.198315 0.292135 0.5 0.241573 0.078652 0.550562 0.449438 0.286517 0.117978 0.168539 4.690468 10 NMV_1332 2192294 CDS -1 1324340 1324696 357 validated/Curated no folB dihydroneopterin aldolase (DHNA) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 4.1.2.25 H2NEOPTERINALDOL-RXN$RXN-10856 PWY-6147 2018-01-23 18:07:18 no Catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. 1 vladimir 0.226891 0.1961 0.330532 0.246499 0.526611 0.473389 0.193277 0.176471 0.453782 0.176471 0.630252 0.369748 0.336134 0.12605 0.193277 0.344538 0.319328 0.680672 0.151261 0.285714 0.344538 0.218487 0.630252 0.369748 0.685291 13408.955 0.00678 0.211864 0.432203 0.313559 0.101695 0.584746 0.415254 0.347458 0.152542 0.194915 4.840218 9.771186 NMV_1333 2192295 CDS +3 1324752 1325354 603 validated/Curated no plsY glycerol-3-phosphate acyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.1 : Phospholipid ; 2.3.1.275 RXN-10462$RXN-1381$RXN-9591 PWY-5667$PWY-5981$PWY0-1319$PWY4FS-7$PWY4FS-8 2020-04-22 16:45:27 no Catalyses the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilises acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. 2 vladimir 0.200663 0.2952 0.252073 0.252073 0.547264 0.452736 0.233831 0.18408 0.378109 0.20398 0.562189 0.437811 0.164179 0.293532 0.159204 0.383085 0.452736 0.547264 0.20398 0.40796 0.218905 0.169154 0.626866 0.373134 0.621162 20819.095 0.907 0.37 0.55 0.315 0.1 0.72 0.28 0.14 0.105 0.035 9.964607 8.01 NMV_1334 2192296 CDS +3 1325442 1326287 846 validated/Curated no rlmJ ribosomal RNA large subunit methyltransferase J 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.266 2018-01-30 15:51:46 no 22847818 Catalyses the following reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA <=> S-adenosyl-L-homocysteine + N(6)-methyladenine(2030) in 23S rRNA 2 vladimir 0.243499 0.3180 0.248227 0.190307 0.566194 0.433806 0.195035 0.329787 0.304965 0.170213 0.634752 0.365248 0.340426 0.198582 0.184397 0.276596 0.382979 0.617021 0.195035 0.425532 0.255319 0.124113 0.680851 0.319149 0.633751 32002.63 -0.379715 0.238434 0.419929 0.224199 0.142349 0.576512 0.423488 0.27758 0.163701 0.113879 8.331459 9.462633 NMV_1335 2192297 CDS +2 1326533 1327507 975 validated/Curated no fbp fructose-1,6-bisphosphatase (D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 3.1.3.11 F16BDEPHOS-RXN GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-31 14:53:16 no Catalyses the following reaction: D-fructose 1,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate. 1 vladimir 0.273846 0.3077 0.232821 0.185641 0.540513 0.459487 0.270769 0.246154 0.356923 0.126154 0.603077 0.396923 0.316923 0.218462 0.16 0.304615 0.378462 0.621538 0.233846 0.458462 0.181538 0.126154 0.64 0.36 0.664077 35593.295 -0.13858 0.287037 0.493827 0.228395 0.092593 0.567901 0.432099 0.219136 0.108025 0.111111 5.478523 9.558642 NMV_1336 2192298 CDS -1 1327649 1327867 219 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:44:16 no 2 vladimir 0.342466 0.2329 0.223744 0.200913 0.456621 0.543379 0.315068 0.191781 0.328767 0.164384 0.520548 0.479452 0.452055 0.178082 0.09589 0.273973 0.273973 0.726027 0.260274 0.328767 0.246575 0.164384 0.575342 0.424658 0.812705 8250.135 -0.669444 0.208333 0.402778 0.222222 0.083333 0.458333 0.541667 0.375 0.194444 0.180556 6.799782 8.541667 NMV_1338 2192300 fCDS +3 1328211 1328309 99 validated/Curated pseudo putative glutaredoxin 4 (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 1 : Unknown 2018-01-23 18:13:00 no Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. 3 vladimir 0.222222 0.2525 0.242424 0.282828 0.494949 0.50505 0.151515 0.272727 0.272727 0.30303 0.545455 0.454545 0.212121 0.30303 0.121212 0.363636 0.424242 0.575758 0.30303 0.181818 0.333333 0.181818 0.515152 0.484848 0.484469 3444.965 0.51875 0.3125 0.5 0.28125 0.0625 0.65625 0.34375 0.125 0.0625 0.0625 5.786888 8.40625 NMV_1339 2192301 fCDS +2 1328279 1328473 195 validated/Curated pseudo putative glutaredoxin 4 (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 1 : Unknown 2018-01-23 18:12:56 no Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. 3 vladimir 0.2827 0.2321 0.21519 0.270042 0.447257 0.552743 0.329114 0.265823 0.265823 0.139241 0.531646 0.468354 0.240506 0.189873 0.240506 0.329114 0.43038 0.56962 0.278481 0.240506 0.139241 0.341772 0.379747 0.620253 0.41767 8720.785 0.028205 0.24359 0.461538 0.25641 0.102564 0.615385 0.384615 0.192308 0.089744 0.102564 5.16407 9.038462 NMV_1340 2192302 CDS +1 1328641 1330416 1776 validated/Curated no ggt glutathione hydrolase/gamma-glutamyltranspeptidase proenzyme 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.10 : Glutathione ; 3.4.19.13, 2.3.2.2 GAMMA-GLUTAMYLTRANSFERASE-RXN 2018-01-23 18:21:02 no This protein is involved in the pathway of glutathione metabolism, which is part of sulfur metabolism. Catalyses the following reactions: a (5-L-glutamyl)-peptide + an amino acid <=> a peptide + a 5-L-glutamyl amino acid and glutathione + H2O = L-cysteinylglycine + L-glutamate. 3 vladimir 0.265788 0.2109 0.257551 0.265788 0.468424 0.531576 0.252059 0.202636 0.359143 0.186161 0.561779 0.438221 0.291598 0.261944 0.16804 0.278418 0.429984 0.570016 0.253707 0.16804 0.24547 0.332784 0.413509 0.586491 0.558049 65155.355 -0.131023 0.326733 0.549505 0.222772 0.087459 0.567657 0.432343 0.19967 0.10231 0.09736 5.794792 9.165017 NMV_1341 2192303 CDS +3 1330479 1330742 264 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:43:23 no 3 vladimir 0.291667 0.1742 0.242424 0.291667 0.416667 0.583333 0.25 0.193182 0.363636 0.193182 0.556818 0.443182 0.306818 0.238636 0.136364 0.318182 0.375 0.625 0.318182 0.090909 0.227273 0.363636 0.318182 0.681818 0.515491 9408.41 0.235632 0.310345 0.505747 0.275862 0.091954 0.597701 0.402299 0.172414 0.08046 0.091954 5.039314 8.873563 NMV_1343 2192305 CDS +1 1330897 1332147 1251 validated/Curated no glyA serine hydroxymethyltransferase (serine methylase; SHMT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.10 : Glycine ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 2.1.2.1 GLYOHMETRANS-RXN$RXN-6321$RXN0-5240 1CMET2-PWY$GLYSYN-PWY$PWY-2161$PWY-2201 2018-01-30 13:43:54 no Catalyses the following reaction: 5,10-methylenetetrahydrofolate + glycine + H(2)O <=> tetrahydrofolate + L-serine. 2 vladimir 0.261391 0.3126 0.236611 0.189448 0.549161 0.450839 0.235012 0.201439 0.402878 0.160671 0.604317 0.395683 0.340528 0.256595 0.139089 0.263789 0.395683 0.604317 0.208633 0.479616 0.167866 0.143885 0.647482 0.352518 0.822585 45057.415 -0.160096 0.314904 0.533654 0.213942 0.105769 0.579327 0.420673 0.237981 0.127404 0.110577 6.206871 9.588942 NMV_1344 2192306 CDS +2 1332239 1332883 645 validated/Curated no dedA DedA protein (DSG-1 protein) 2b : Function from indirect experimental evidences (e.g. phenotypes) m : membrane component 5 : Inner membrane protein 2008-05-06 12:42:58 no 2 vladimir 0.195349 0.2775 0.235659 0.291473 0.513178 0.486822 0.251163 0.2 0.339535 0.209302 0.539535 0.460465 0.213953 0.204651 0.162791 0.418605 0.367442 0.632558 0.12093 0.427907 0.204651 0.246512 0.632558 0.367442 0.701343 23453.115 0.78785 0.285047 0.453271 0.313084 0.158879 0.724299 0.275701 0.172897 0.121495 0.051402 9.741692 8.490654 NMV_1345 2192307 CDS +2 1332902 1334812 1911 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 2 : Cytoplasmic 2008-05-06 12:42:31 no 1 vladimir 0.277342 0.2585 0.253271 0.210884 0.511774 0.488226 0.248038 0.216641 0.372057 0.163265 0.588697 0.411303 0.372057 0.174254 0.163265 0.290424 0.33752 0.66248 0.211931 0.384615 0.22449 0.178964 0.609105 0.390895 0.680496 71556.385 -0.426415 0.242138 0.433962 0.243711 0.089623 0.504717 0.495283 0.312893 0.150943 0.16195 5.344261 9.083333 NMV_1346 2192308 CDS +1 1334833 1335198 366 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 12:42:17 no 1 vladimir 0.221311 0.2842 0.215847 0.278689 0.5 0.5 0.237705 0.278689 0.221311 0.262295 0.5 0.5 0.204918 0.286885 0.172131 0.336066 0.459016 0.540984 0.221311 0.286885 0.254098 0.237705 0.540984 0.459016 0.563637 13964.21 0.509091 0.297521 0.421488 0.280992 0.181818 0.694215 0.305785 0.132231 0.107438 0.024793 9.902657 8.22314 NMV_1347 2192309 CDS +3 1335162 1336784 1623 validated/Curated no trpE anthranilate synthase component I (glutamine amido-transferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 4.1.3.27 ANTHRANSYN-RXN TRPSYN-PWY 2018-01-23 18:25:05 no Catalyses the following reaction: chorismate + L-glutamine <=> anthranilate + pyruvate + L-glutamate. 2 vladimir 0.251355 0.3354 0.229675 0.183604 0.565041 0.434959 0.25 0.243902 0.361789 0.144309 0.605691 0.394309 0.325203 0.205285 0.178862 0.29065 0.384146 0.615854 0.178862 0.556911 0.148374 0.115854 0.705285 0.294715 0.739736 54720.21 -0.26558 0.266802 0.494908 0.228106 0.107943 0.553971 0.446029 0.264766 0.132383 0.132383 5.568565 9.631365 NMV_1348 2192310 CDS +2 1336781 1337326 546 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:14:16 no 3 vladimir 0.375458 0.1795 0.179487 0.265568 0.358974 0.641026 0.401099 0.148352 0.258242 0.192308 0.406593 0.593407 0.362637 0.214286 0.181319 0.241758 0.395604 0.604396 0.362637 0.175824 0.098901 0.362637 0.274725 0.725275 0.51171 20918.74 -0.700552 0.298343 0.464088 0.154696 0.121547 0.430939 0.569061 0.281768 0.143646 0.138122 6.861092 9.314917 NMV_1349 2192311 CDS +1 1337323 1338459 1137 validated/Curated no purK N5-carboxyaminoimidazole ribonucleotide synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.4.18 RXN0-742 PWY-6123 2018-01-23 18:29:31 no Catalyses the following reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) <=> ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole. 2 vladimir 0.270888 0.2797 0.243624 0.205805 0.523307 0.476693 0.258575 0.229551 0.364116 0.147757 0.593668 0.406332 0.335092 0.245383 0.147757 0.271768 0.39314 0.60686 0.218997 0.364116 0.218997 0.197889 0.583113 0.416887 0.713171 41391.555 -0.219312 0.298942 0.526455 0.21164 0.089947 0.547619 0.452381 0.248677 0.12963 0.119048 5.816902 9.708995 NMV_1350 2192312 CDS +2 1338506 1338988 483 validated/Curated no putative acetyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 18:29:59 no Belongs to the family of Gcn5-related acetyltransferases (GNATs). 2 vladimir 0.271222 0.3292 0.190476 0.20911 0.519669 0.480331 0.236025 0.310559 0.254658 0.198758 0.565217 0.434783 0.341615 0.192547 0.136646 0.329193 0.329193 0.670807 0.236025 0.484472 0.180124 0.099379 0.664596 0.335404 0.604756 18145.355 0.071875 0.25625 0.425 0.28125 0.15 0.56875 0.43125 0.225 0.13125 0.09375 6.458839 8.425 NMV_1351 2192313 CDS +2 1339094 1340149 1056 validated/Curated no putative sulfate-binding protein Sbp 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 1.8.2 : Sulfur metabolism ; 2018-01-30 19:12:17 no Specifically binds sulfate and is involved in its transmembrane transport. 2 vladimir 0.299242 0.3475 0.193182 0.160038 0.54072 0.45928 0.284091 0.213068 0.340909 0.161932 0.553977 0.446023 0.352273 0.278409 0.142045 0.227273 0.420455 0.579545 0.261364 0.551136 0.096591 0.090909 0.647727 0.352273 0.695065 38411.44 -0.454416 0.324786 0.555556 0.179487 0.111111 0.521368 0.478632 0.216524 0.11396 0.102564 6.605385 9.193732 NMV_1353 2192315 CDS +1 1340875 1341480 606 validated/Curated no putative Smr-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-23 18:31:25 no Belongs to a family of Smr (Small MutS Related) proteins, which are thought to interact with MutS1. 2 vladimir 0.358086 0.3069 0.19967 0.135314 0.506601 0.493399 0.287129 0.262376 0.316832 0.133663 0.579208 0.420792 0.460396 0.168317 0.163366 0.207921 0.331683 0.668317 0.326733 0.490099 0.118812 0.064356 0.608911 0.391089 0.693754 22967.86 -1.023383 0.218905 0.462687 0.159204 0.104478 0.467662 0.532338 0.293532 0.169154 0.124378 9.150276 9.706468 NMV_misc_RNA_9 2662692 misc_RNA +1 1341543 1341908 366 validated/Curated no tmRNA (10Sa RNA; SsrA) 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:43:21 28334889 tmRNA is so-named for its dual tRNA-like and mRNA-like nature. tmRNA engages in a trans-translation process, adding a C-terminal peptide tag to the unfinished protein a stalled ribosome. The tmRNA-directed tag targets the unfinished protein for proteolysis. vladimir NMV_1355 2192317 CDS -3 1342224 1342973 750 validated/Curated no IS150 group transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-23 18:31:47 no Belongs to the IS3 family. 1 vladimir 0.302667 0.2147 0.256 0.226667 0.470667 0.529333 0.288 0.244 0.284 0.184 0.528 0.472 0.356 0.184 0.18 0.28 0.364 0.636 0.264 0.216 0.304 0.216 0.52 0.48 0.499701 28710.22 -0.469478 0.2249 0.409639 0.220884 0.136546 0.546185 0.453815 0.281124 0.192771 0.088353 9.927544 9.305221 NMV_1356 2192318 CDS -2 1342978 1343388 411 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-06 12:40:37 no 1 vladimir 0.301703 0.2360 0.265207 0.19708 0.501217 0.498783 0.233577 0.255474 0.328467 0.182482 0.583942 0.416058 0.394161 0.248175 0.138686 0.218978 0.386861 0.613139 0.277372 0.20438 0.328467 0.189781 0.532847 0.467153 0.534833 15720.675 -0.640441 0.272059 0.382353 0.176471 0.110294 0.514706 0.485294 0.316176 0.205882 0.110294 9.721504 9.455882 NMV_1357 2192319 CDS -1 1343381 1343548 168 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-21 12:45:27 no 1 vladimir 0.271386 0.2596 0.286136 0.182891 0.545723 0.454277 0.274336 0.176991 0.345133 0.20354 0.522124 0.477876 0.265487 0.300885 0.238938 0.19469 0.539823 0.460177 0.274336 0.300885 0.274336 0.150442 0.575221 0.424779 0.621654 12298.435 -0.408036 0.383929 0.526786 0.151786 0.116071 0.553571 0.446429 0.214286 0.133929 0.080357 9.752159 9.035714 NMV_1358 2192320 CDS -2 1343644 1343817 174 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-06 12:39:06 no 1 vladimir 0.298851 0.3218 0.247126 0.132184 0.568966 0.431034 0.344828 0.258621 0.275862 0.12069 0.534483 0.465517 0.293103 0.293103 0.224138 0.189655 0.517241 0.482759 0.258621 0.413793 0.241379 0.086207 0.655172 0.344828 0.575623 6317.21 -0.610526 0.385965 0.473684 0.105263 0.087719 0.508772 0.491228 0.298246 0.263158 0.035088 11.143486 9.070175 NMV_1359 2192321 CDS -1 1343831 1344334 504 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:38:55 no 1 vladimir 0.232143 0.3095 0.253968 0.204365 0.563492 0.436508 0.238095 0.22619 0.363095 0.172619 0.589286 0.410714 0.321429 0.220238 0.202381 0.255952 0.422619 0.577381 0.136905 0.482143 0.196429 0.184524 0.678571 0.321429 0.709102 18836.41 -0.450898 0.293413 0.502994 0.167665 0.137725 0.54491 0.45509 0.251497 0.137725 0.113772 7.101204 10.365269 NMV_1360 2192322 CDS -2 1344424 1344906 483 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 12:38:42 no 3 vladimir 0.3147 0.1429 0.182195 0.360248 0.325052 0.674948 0.291925 0.149068 0.254658 0.304348 0.403727 0.596273 0.310559 0.142857 0.136646 0.409938 0.279503 0.720497 0.341615 0.136646 0.15528 0.36646 0.291925 0.708075 0.50793 18800.865 0.38125 0.1875 0.33125 0.3 0.16875 0.6375 0.3625 0.24375 0.15625 0.0875 9.444115 8.4375 NMV_1361 2192323 CDS -3 1344903 1345871 969 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:17:05 no 3 vladimir 0.339525 0.1765 0.20227 0.281734 0.378741 0.621259 0.309598 0.185759 0.30031 0.204334 0.486068 0.513932 0.356037 0.204334 0.157895 0.281734 0.362229 0.637771 0.352941 0.139319 0.148607 0.359133 0.287926 0.712074 0.526421 35829.835 -0.369565 0.28882 0.47205 0.236025 0.096273 0.465839 0.534161 0.248447 0.127329 0.121118 5.672493 8.779503 NMV_1363 2192325 CDS -1 1346105 1346350 246 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 13:16:14 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_1364) encodes the cognate antitoxin. 3 vladimir 0.357724 0.1829 0.231707 0.227642 0.414634 0.585366 0.243902 0.146341 0.439024 0.170732 0.585366 0.414634 0.426829 0.231707 0.073171 0.268293 0.304878 0.695122 0.402439 0.170732 0.182927 0.243902 0.353659 0.646341 0.640437 9115.92 -0.333333 0.246914 0.444444 0.209877 0.111111 0.530864 0.469136 0.296296 0.111111 0.185185 4.560478 9.469136 NMV_1364 2192326 CDS -3 1346379 1346756 378 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 13:16:10 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_1363) encodes the cognate toxin. 3 vladimir 0.328042 0.1640 0.248677 0.259259 0.412698 0.587302 0.301587 0.126984 0.373016 0.198413 0.5 0.5 0.333333 0.214286 0.198413 0.253968 0.412698 0.587302 0.349206 0.150794 0.174603 0.325397 0.325397 0.674603 0.543025 13686.95 -0.4168 0.336 0.472 0.192 0.088 0.496 0.504 0.28 0.152 0.128 8.87513 8.704 NMV_1366 2192328 CDS +1 1347061 1347351 291 validated/Curated no putative DNA-binding phage protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2015-11-19 18:36:13 no 1 vladimir 0.282828 0.2121 0.292929 0.212121 0.505051 0.494949 0.30303 0.232323 0.343434 0.121212 0.575758 0.424242 0.333333 0.131313 0.20202 0.333333 0.333333 0.666667 0.212121 0.272727 0.333333 0.181818 0.606061 0.393939 0.458935 11042.315 -0.234694 0.22449 0.428571 0.295918 0.061224 0.510204 0.489796 0.306122 0.173469 0.132653 9.159782 9.010204 NMV_1367 2192329 CDS +3 1347396 1348271 876 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:17:32 no 1 vladimir 0.289954 0.2146 0.309361 0.186073 0.523973 0.476027 0.291096 0.215753 0.400685 0.092466 0.616438 0.383562 0.342466 0.181507 0.191781 0.284247 0.373288 0.626712 0.236301 0.246575 0.335616 0.181507 0.582192 0.417808 0.617114 32618.75 -0.4811 0.274914 0.450172 0.216495 0.054983 0.474227 0.525773 0.323024 0.140893 0.182131 4.875465 9.958763 NMV_1368 2192330 fCDS +1 1348252 1348611 360 validated/Curated pseudo phage transposase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2008-06-18 16:26:23 no 1 vladimir 0.249683 0.2991 0.297845 0.153359 0.596958 0.403042 0.26616 0.34981 0.285171 0.098859 0.634981 0.365019 0.262357 0.292776 0.247148 0.197719 0.539924 0.460076 0.220532 0.254753 0.361217 0.163498 0.61597 0.38403 0.465606 29950.675 -0.896947 0.28626 0.458015 0.148855 0.080153 0.484733 0.515267 0.332061 0.259542 0.072519 11.774849 10.774809 NMV_1369 2192331 fCDS +2 1348607 1349155 549 validated/Curated pseudo phage transposase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2008-06-18 16:26:36 no 2 vladimir 0.246528 0.4149 0.208333 0.130208 0.623264 0.376736 0.260417 0.348958 0.255208 0.135417 0.604167 0.395833 0.296875 0.276042 0.213542 0.213542 0.489583 0.510417 0.182292 0.619792 0.15625 0.041667 0.776042 0.223958 0.611853 21681.87 -0.642408 0.319372 0.465969 0.167539 0.151832 0.486911 0.513089 0.303665 0.219895 0.08377 10.265816 9.246073 NMV_1370 2192332 CDS +3 1349235 1349438 204 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-19 18:35:08 no 2 vladimir 0.340909 0.2689 0.223485 0.166667 0.492424 0.507576 0.375 0.181818 0.329545 0.113636 0.511364 0.488636 0.295455 0.284091 0.113636 0.306818 0.397727 0.602273 0.352273 0.340909 0.227273 0.079545 0.568182 0.431818 0.558989 9634.99 -0.022989 0.287356 0.45977 0.229885 0.068966 0.551724 0.448276 0.275862 0.172414 0.103448 9.630501 8.758621 NMV_1371 2192333 CDS +1 1349476 1349757 282 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:17:56 no 2 vladimir 0.281346 0.3150 0.217125 0.186544 0.53211 0.46789 0.275229 0.256881 0.284404 0.183486 0.541284 0.458716 0.33945 0.220183 0.229358 0.211009 0.449541 0.550459 0.229358 0.46789 0.137615 0.165138 0.605505 0.394495 0.609832 12619.995 -0.712037 0.259259 0.444444 0.148148 0.166667 0.537037 0.462963 0.333333 0.212963 0.12037 9.183815 10.462963 NMV_1372 2192334 CDS +3 1349769 1349972 204 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:36:48 no 2 vladimir 0.289216 0.2794 0.284314 0.147059 0.563726 0.436275 0.25 0.279412 0.323529 0.147059 0.602941 0.397059 0.367647 0.191176 0.205882 0.235294 0.397059 0.602941 0.25 0.367647 0.323529 0.058824 0.691176 0.308824 0.540751 8007.86 -0.749254 0.208955 0.402985 0.19403 0.119403 0.507463 0.492537 0.313433 0.164179 0.149254 6.760368 10.910448 NMV_1373 2192335 CDS -1 1350248 1351255 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-23 18:35:41 no Belongs to the IS5 family. 2 vladimir 0.27381 0.3016 0.238095 0.186508 0.539683 0.460317 0.270833 0.28869 0.28869 0.151786 0.577381 0.422619 0.354167 0.205357 0.193452 0.247024 0.39881 0.60119 0.196429 0.410714 0.232143 0.160714 0.642857 0.357143 0.644349 38445.5 -0.567761 0.274627 0.426866 0.202985 0.116418 0.486567 0.513433 0.301493 0.185075 0.116418 9.344566 9.525373 NMV_1374 2192336 CDS +2 1351442 1351624 183 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-06 12:36:23 no 1 vladimir 0.251366 0.1913 0.311475 0.245902 0.502732 0.497268 0.229508 0.180328 0.344262 0.245902 0.52459 0.47541 0.327869 0.196721 0.196721 0.278689 0.393443 0.606557 0.196721 0.196721 0.393443 0.213115 0.590164 0.409836 0.644562 6783.515 -0.303333 0.283333 0.483333 0.183333 0.133333 0.583333 0.416667 0.233333 0.133333 0.1 8.943382 9.416667 NMV_1375 2192337 CDS -3 1351674 1352675 1002 validated/Curated no dusC tRNA-dihydrouridine(16) synthase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 1.3.1.- RXN0-1281 2018-01-23 18:36:22 no Catalyses the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs 2 vladimir 0.270459 0.2754 0.263473 0.190619 0.538922 0.461078 0.299401 0.221557 0.344311 0.134731 0.565868 0.434132 0.305389 0.209581 0.203593 0.281437 0.413174 0.586826 0.206587 0.39521 0.242515 0.155689 0.637725 0.362275 0.62497 37161.44 -0.247748 0.282282 0.498498 0.222222 0.096096 0.552553 0.447447 0.276276 0.159159 0.117117 8.819588 9.711712 NMV_1376 2192338 CDS -2 1352752 1356585 3834 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 18:37:09 no Is an oxygen-dependent oxidoreductase, which uses FAD as a co-factor. 2 vladimir 0.247783 0.3007 0.261346 0.190141 0.562076 0.437924 0.260563 0.22457 0.372457 0.14241 0.597027 0.402973 0.311424 0.214397 0.187793 0.286385 0.402191 0.597809 0.171362 0.463224 0.223787 0.141628 0.687011 0.312989 0.705938 141634.47 -0.229679 0.282694 0.504307 0.226312 0.099452 0.555991 0.444009 0.285826 0.161316 0.124511 8.418831 9.66249 NMV_misc_RNA_8 2194967 misc_RNA +1 1356839 1357033 195 validated/Curated no signal recognition particle RNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-28 17:41:53 28334889 This is the RNA component of the signal recognition particle (SRP), a universally conserved RNA:protein (ribonucleoprotein) complex involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. SRP binds to the hydrophobic signal sequence of the ribosome-nascent chain as it emerges from the ribosomes. vladimir NMV_1377 2192339 CDS +2 1357163 1357582 420 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-06 12:35:43 no 1 vladimir 0.307143 0.2143 0.240476 0.238095 0.454762 0.545238 0.371429 0.15 0.357143 0.121429 0.507143 0.492857 0.314286 0.228571 0.135714 0.321429 0.364286 0.635714 0.235714 0.264286 0.228571 0.271429 0.492857 0.507143 0.564322 14721.33 0.026619 0.323741 0.597122 0.230216 0.05036 0.561151 0.438849 0.172662 0.100719 0.071942 8.751762 9.460432 NMV_1378 2192340 CDS +2 1357679 1359370 1692 validated/Curated no dld quinone-dependent D-lactate dehydrogenase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.23 : Methylglyoxal metabolism ; 1.1.5.12 DLACTDEHYDROGFAD-RXN$RXN-12648$RXN0-5259$RXN0-5261 PWY-5386 2018-01-31 14:24:56 no Catalyses the following reaction: (R)-lactate + a quinone <=> pyruvate + a quinol. 2 vladimir 0.264775 0.3014 0.250591 0.183215 0.552009 0.447991 0.25 0.225177 0.356383 0.16844 0.58156 0.41844 0.374113 0.195035 0.161348 0.269504 0.356383 0.643617 0.170213 0.484043 0.234043 0.111702 0.718085 0.281915 0.767811 63403.41 -0.41048 0.262877 0.472469 0.204263 0.138544 0.53286 0.46714 0.296625 0.16341 0.133215 6.261879 9.660746 NMV_1379 2192341 CDS +2 1359665 1360036 372 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-05-06 12:35:06 no 2 vladimir 0.196237 0.2957 0.293011 0.215054 0.58871 0.41129 0.169355 0.233871 0.346774 0.25 0.580645 0.419355 0.217742 0.282258 0.217742 0.282258 0.5 0.5 0.201613 0.370968 0.314516 0.112903 0.685484 0.314516 0.599291 13361.97 0.196748 0.357724 0.528455 0.211382 0.162602 0.699187 0.300813 0.130081 0.097561 0.03252 9.777153 9.154472 NMV_1380 2192342 CDS +3 1360191 1360739 549 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:34:54 no 1 vladimir 0.265938 0.3206 0.238616 0.174863 0.559199 0.440801 0.229508 0.185792 0.442623 0.142077 0.628415 0.371585 0.311475 0.289617 0.114754 0.284153 0.404372 0.595628 0.256831 0.486339 0.15847 0.098361 0.644809 0.355191 0.689338 19166.105 0.174176 0.357143 0.554945 0.230769 0.071429 0.604396 0.395604 0.186813 0.087912 0.098901 5.221107 9.593407 NMV_1381 2192343 fCDS +3 1360869 1361348 480 validated/Curated pseudo putative acyl-CoA dehydrogenase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.3.8.- ACYLCOADEHYDROG-RXN$BUTYRYL-COA-DEHYDROGENASE-RXN$RXN-11734 FAO-PWY 2018-01-22 11:48:07 no 2 vladimir 0.26875 0.3042 0.270833 0.15625 0.575 0.425 0.25625 0.18125 0.425 0.1375 0.60625 0.39375 0.325 0.225 0.19375 0.25625 0.41875 0.58125 0.225 0.50625 0.19375 0.075 0.7 0.3 0.697485 16927.53 -0.081132 0.352201 0.534591 0.220126 0.09434 0.603774 0.396226 0.220126 0.113208 0.106918 5.790733 9.63522 NMV_1382 2192344 fCDS +3 1361349 1361960 612 validated/Curated pseudo putative acyl-CoA dehydrogenase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.3.8.- ACYLCOADEHYDROG-RXN$BUTYRYL-COA-DEHYDROGENASE-RXN$RXN-11734 FAO-PWY 2018-01-22 11:47:58 no 2 vladimir 0.250432 0.3368 0.252159 0.160622 0.588946 0.411054 0.264249 0.212435 0.409326 0.11399 0.621762 0.378238 0.259067 0.243523 0.202073 0.295337 0.445596 0.554404 0.227979 0.554404 0.145078 0.072539 0.699482 0.300518 0.673335 20576.825 0.203646 0.348958 0.510417 0.239583 0.088542 0.625 0.375 0.21875 0.104167 0.114583 5.237556 9.104167 NMV_1383 2192345 CDS +3 1362321 1362434 114 validated/Curated partial truncated rubredoxin (N-terminal 75% of the protein) 5 : Unknown function c : carrier 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-23 18:38:58 no Is a low molecular weight iron-containing bacterial protein involved in electron transfer, sometimes replacing ferredoxin as an electron carrier. 2 vladimir 0.317829 0.2791 0.232558 0.170543 0.511628 0.488372 0.255814 0.232558 0.302326 0.209302 0.534884 0.465116 0.418605 0.162791 0.232558 0.186047 0.395349 0.604651 0.27907 0.44186 0.162791 0.116279 0.604651 0.395349 0.698793 4954.425 -0.985714 0.214286 0.428571 0.119048 0.166667 0.547619 0.452381 0.333333 0.166667 0.166667 5.463036 11.190476 NMNmiscRNA0150 54907859 misc_RNA -1 1364673 1364798 126 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 10:57:27 28334889 Function unknown. vladimir NMV_1384 2192346 CDS +1 1364923 1366707 1785 validated/Curated no nhhA autotransporter adhesin NhhA 1b : Function from experimental evidences in the studied species m : membrane component 8 : Outer membrane-associated 2018-01-23 18:39:50 no 14726537, 16803596 Involved in adhesion of capsulated meningococci to host epithelial cells. Interacts with laminin and heparan sulfate, promoting the adherence to the extracellular matrix (ECM) components. 1 vladimir 0.312605 0.2403 0.25042 0.196639 0.490756 0.509244 0.384874 0.094118 0.398319 0.122689 0.492437 0.507563 0.332773 0.267227 0.176471 0.223529 0.443697 0.556303 0.220168 0.359664 0.176471 0.243697 0.536134 0.463866 0.658165 62294.065 -0.427946 0.393939 0.658249 0.191919 0.058923 0.468013 0.531987 0.223906 0.112795 0.111111 6.005852 8.968013 NMV_1385 2192347 CDS +3 1366839 1367846 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-23 18:40:03 no Belongs to the IS5 family. 2 vladimir 0.289683 0.3006 0.22123 0.188492 0.521825 0.478175 0.291667 0.28869 0.267857 0.151786 0.556548 0.443452 0.366071 0.208333 0.178571 0.247024 0.386905 0.613095 0.21131 0.404762 0.217262 0.166667 0.622024 0.377976 0.638738 38834.9 -0.61791 0.259701 0.41791 0.202985 0.122388 0.474627 0.525373 0.298507 0.18209 0.116418 9.310814 9.531343 NMV_1386 2192348 CDS +3 1367982 1368173 192 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:33:41 no 3 vladimir 0.348958 0.1927 0.197917 0.260417 0.390625 0.609375 0.390625 0.125 0.296875 0.1875 0.421875 0.578125 0.3125 0.28125 0.109375 0.296875 0.390625 0.609375 0.34375 0.171875 0.1875 0.296875 0.359375 0.640625 0.481854 6849.78 0.050794 0.333333 0.444444 0.285714 0.031746 0.507937 0.492063 0.269841 0.15873 0.111111 9.523689 7.238095 NMV_1387 2192349 CDS -1 1368170 1368676 507 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:18:23 no 1 vladimir 0.236686 0.2308 0.313609 0.218935 0.544379 0.455621 0.260355 0.183432 0.372781 0.183432 0.556213 0.443787 0.307692 0.272189 0.147929 0.272189 0.420118 0.579882 0.142012 0.236686 0.420118 0.201183 0.656805 0.343195 0.669427 18723.845 -0.302976 0.309524 0.470238 0.178571 0.089286 0.535714 0.464286 0.291667 0.142857 0.14881 5.47361 9.571429 NMV_1388 2192350 CDS -2 1368679 1368876 198 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-12 16:00:02 no 2 vladimir 0.319444 0.2269 0.282407 0.171296 0.509259 0.490741 0.284722 0.256944 0.347222 0.111111 0.604167 0.395833 0.3125 0.194444 0.277778 0.215278 0.472222 0.527778 0.361111 0.229167 0.222222 0.1875 0.451389 0.548611 0.546811 15818.5 -0.693007 0.321678 0.468531 0.174825 0.062937 0.503497 0.496503 0.286713 0.195804 0.090909 10.360451 9.797203 NMV_1389 2192351 CDS -3 1368873 1369139 267 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:18:52 no 2 vladimir 0.310861 0.2172 0.277154 0.194757 0.494382 0.505618 0.292135 0.168539 0.359551 0.179775 0.52809 0.47191 0.404494 0.202247 0.146067 0.247191 0.348315 0.651685 0.235955 0.280899 0.325843 0.157303 0.606742 0.393258 0.636643 10293.295 -0.75 0.227273 0.409091 0.181818 0.125 0.454545 0.545455 0.397727 0.215909 0.181818 7.96125 8.886364 NMV_1390 2192352 CDS -1 1369151 1369489 339 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:19:11 no 1 vladimir 0.224189 0.2094 0.271386 0.294985 0.480826 0.519174 0.19469 0.19469 0.389381 0.221239 0.584071 0.415929 0.345133 0.176991 0.185841 0.292035 0.362832 0.637168 0.132743 0.256637 0.238938 0.371681 0.495575 0.504425 0.692869 12859.065 -0.2625 0.241071 0.5 0.232143 0.142857 0.5625 0.4375 0.285714 0.133929 0.151786 5.054802 10.464286 NMV_1391 2192353 CDS -2 1369486 1369704 219 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:32:40 no 1 vladimir 0.319635 0.1644 0.255708 0.260274 0.420091 0.579909 0.315068 0.082192 0.315068 0.287671 0.39726 0.60274 0.383562 0.205479 0.178082 0.232877 0.383562 0.616438 0.260274 0.205479 0.273973 0.260274 0.479452 0.520548 0.573882 8604.485 -0.670833 0.25 0.430556 0.152778 0.194444 0.513889 0.486111 0.305556 0.194444 0.111111 9.601021 9.944444 NMV_1392 2192354 CDS +1 1369717 1369887 171 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:32:28 no 2 vladimir 0.339181 0.2456 0.22807 0.187135 0.473684 0.526316 0.315789 0.157895 0.350877 0.175439 0.508772 0.491228 0.438596 0.210526 0.157895 0.192982 0.368421 0.631579 0.263158 0.368421 0.175439 0.192982 0.54386 0.45614 0.79464 6403.005 -0.657143 0.303571 0.446429 0.160714 0.142857 0.5 0.5 0.303571 0.178571 0.125 8.053856 9.892857 NMV_1393 2192355 CDS -3 1369932 1370114 183 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:32:15 no 2 vladimir 0.240437 0.2787 0.31694 0.163934 0.595628 0.404372 0.213115 0.245902 0.393443 0.147541 0.639344 0.360656 0.311475 0.311475 0.180328 0.196721 0.491803 0.508197 0.196721 0.278689 0.377049 0.147541 0.655738 0.344262 0.703844 6536.085 -0.651667 0.283333 0.6 0.15 0.1 0.583333 0.416667 0.233333 0.133333 0.1 6.932976 10.55 NMV_1394 2192356 CDS -2 1370134 1370553 420 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:32:02 no 1 vladimir 0.285714 0.2405 0.280952 0.192857 0.521429 0.478571 0.264286 0.221429 0.385714 0.128571 0.607143 0.392857 0.407143 0.207143 0.142857 0.242857 0.35 0.65 0.185714 0.292857 0.314286 0.207143 0.607143 0.392857 0.658025 15189.8 -0.409353 0.302158 0.453237 0.208633 0.086331 0.539568 0.460432 0.273381 0.179856 0.093525 9.620247 9.165468 NMV_1395 2192357 CDS -1 1370525 1370761 237 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-06 12:31:49 no 1 vladimir 0.21097 0.1941 0.329114 0.265823 0.523207 0.476793 0.227848 0.126582 0.417722 0.227848 0.544304 0.455696 0.265823 0.265823 0.177215 0.291139 0.443038 0.556962 0.139241 0.189873 0.392405 0.278481 0.582278 0.417722 0.649377 8502.375 0.073077 0.333333 0.564103 0.217949 0.115385 0.602564 0.397436 0.217949 0.115385 0.102564 6.869423 9.666667 NMV_1396 2192358 CDS -2 1370764 1370928 165 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-06 12:31:37 no 1 vladimir 0.290909 0.1818 0.333333 0.193939 0.515152 0.484848 0.236364 0.2 0.4 0.163636 0.6 0.4 0.4 0.181818 0.163636 0.254545 0.345455 0.654545 0.236364 0.163636 0.436364 0.163636 0.6 0.4 0.593799 6168.735 -0.462963 0.296296 0.37037 0.148148 0.12963 0.518519 0.481481 0.296296 0.12963 0.166667 4.946068 9.722222 NMV_1398 2192360 CDS -1 1371134 1371679 546 validated/Curated no putative amidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic AMIDASE-RXN$NICOTINAMID-RXN$R311-RXN P344-PWY$PYRIDNUCSAL-PWY 2018-01-23 18:41:52 no Shows some homologies to the N-acetylmuramoyl-L-alanine amidase 3 family that hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. 2 vladimir 0.24359 0.2509 0.307692 0.197802 0.558608 0.441392 0.313187 0.131868 0.417582 0.137363 0.549451 0.450549 0.28022 0.247253 0.21978 0.252747 0.467033 0.532967 0.137363 0.373626 0.285714 0.203297 0.659341 0.340659 0.73519 19289.18 -0.166298 0.370166 0.574586 0.198895 0.077348 0.558011 0.441989 0.259669 0.149171 0.110497 9.121758 9.265193 NMV_1399 2192361 CDS -3 1371987 1372415 429 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:19:44 no 1 vladimir 0.265734 0.1795 0.310023 0.244755 0.48951 0.510489 0.265734 0.167832 0.377622 0.188811 0.545455 0.454545 0.321678 0.174825 0.174825 0.328671 0.34965 0.65035 0.20979 0.195804 0.377622 0.216783 0.573427 0.426573 0.487279 15826.865 -0.019014 0.267606 0.429577 0.260563 0.098592 0.584507 0.415493 0.28169 0.15493 0.126761 7.943733 9.401408 NMV_1400 2192362 CDS -2 1372396 1372830 435 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:20:09 no 1 vladimir 0.268966 0.1931 0.31954 0.218391 0.512644 0.487356 0.255172 0.2 0.4 0.144828 0.6 0.4 0.344828 0.22069 0.193103 0.241379 0.413793 0.586207 0.206897 0.158621 0.365517 0.268966 0.524138 0.475862 0.525218 15913.675 -0.561111 0.305556 0.493056 0.1875 0.083333 0.506944 0.493056 0.361111 0.229167 0.131944 9.595039 9.548611 NMV_1401 2192363 CDS -3 1372983 1373939 957 validated/Curated no IS110 family transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-05-06 12:30:31 no 1 vladimir 0.277952 0.2894 0.248694 0.183908 0.53814 0.46186 0.310345 0.247649 0.322884 0.119122 0.570533 0.429467 0.319749 0.285266 0.144201 0.250784 0.429467 0.570533 0.203762 0.335423 0.278997 0.181818 0.61442 0.38558 0.622724 35402.305 -0.452516 0.308176 0.481132 0.188679 0.091195 0.490566 0.509434 0.292453 0.185535 0.106918 9.712959 9.477987 NMV_1402 2192364 CDS -3 1374537 1376117 1581 validated/Curated no purH bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) and IMP cyclohydrolase (inosinicase; IMP synthetase; ATIC)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 2.1.2.3, 3.5.4.10 AICARTRANSFORM-RXN$IMPCYCLOHYDROLASE-RXN PWY-6123 2018-01-23 18:43:38 no Catalyses the last two steps in de novo purine biosynthesis: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide <=> tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide IMP + H(2)O <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. 2 vladimir 0.243517 0.3276 0.255534 0.173308 0.583175 0.416825 0.258065 0.185958 0.417457 0.13852 0.603416 0.396584 0.309298 0.248577 0.165085 0.27704 0.413662 0.586338 0.163188 0.548387 0.184061 0.104364 0.732448 0.267552 0.788627 56899.265 -0.106654 0.323194 0.551331 0.212928 0.098859 0.568441 0.431559 0.254753 0.127376 0.127376 5.536095 9.441065 NMV_1403 2192365 CDS -3 1376277 1377500 1224 validated/Curated no putative H(+)/Cl(-) exchange transporter ClcA 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-23 18:44:48 no Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. 1 vladimir 0.174978 0.2852 0.296588 0.24322 0.581802 0.418198 0.212598 0.209974 0.383202 0.194226 0.593176 0.406824 0.154856 0.291339 0.186352 0.367454 0.47769 0.52231 0.15748 0.354331 0.32021 0.167979 0.674541 0.325459 0.633865 39891.595 0.770263 0.378947 0.542105 0.278947 0.105263 0.715789 0.284211 0.115789 0.073684 0.042105 9.457253 8.768421 NMV_1404 2192366 CDS -3 1377564 1378397 834 validated/Curated no serB phosphoserine phosphatase (PSP; O-phosphoserine phosphohydrolase; PSPase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.10 : Glycine ; 1.5.1.11 : Serine ; 3.1.3.3 RXN0-5114 SERSYN-PWY 2018-01-23 18:45:20 no Is involved in both serine and glycine biosynthesis. It catalyses the last step in the biosynthesis of serine from carbohydrates: L(or D)-O-phosphoserine + H(2)O <=> L(or D)-serine + phosphate. 1 vladimir 0.213429 0.2518 0.304556 0.230216 0.556355 0.443645 0.18705 0.215827 0.410072 0.18705 0.625899 0.374101 0.291367 0.197842 0.194245 0.316547 0.392086 0.607914 0.161871 0.341727 0.309353 0.18705 0.651079 0.348921 0.645354 30463.68 -0.092419 0.281588 0.469314 0.241877 0.086643 0.577617 0.422383 0.292419 0.133574 0.158845 4.98185 9.411552 NMV_1405 2192367 CDS +1 1378687 1380228 1542 validated/Curated no pntA NAD(P) transhydrogenase subunit alpha (pyridine nucleotide transhydrogenase subunit alpha; nicotinamide nucleotide transhydrogenase subunit alpha) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.7.44 : NAD phosphorylation and dephosphorylation ; 1.6.1.2 TRANS-RXN0-277 NADPHOS-DEPHOS-PWY 2018-01-23 18:46:59 no The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 2 vladimir 0.216602 0.3132 0.275616 0.194553 0.588846 0.411154 0.266537 0.184825 0.400778 0.14786 0.585603 0.414397 0.231518 0.289883 0.153696 0.324903 0.44358 0.55642 0.151751 0.464981 0.272374 0.110895 0.737354 0.262646 0.745764 54033.59 0.34269 0.345029 0.567251 0.25731 0.072125 0.637427 0.362573 0.177388 0.089669 0.087719 6.096107 8.986355 NMV_1406 2192368 CDS +1 1380232 1380615 384 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-06 12:29:08 no 2 vladimir 0.1875 0.3073 0.257812 0.247396 0.565104 0.434896 0.210938 0.195312 0.359375 0.234375 0.554688 0.445312 0.1875 0.34375 0.179688 0.289062 0.523438 0.476562 0.164062 0.382812 0.234375 0.21875 0.617188 0.382812 0.692427 13678.44 0.554331 0.433071 0.551181 0.165354 0.173228 0.700787 0.299213 0.133858 0.102362 0.031496 9.403954 9.614173 NMV_1407 2192369 CDS +3 1380681 1382066 1386 validated/Curated no pntB NAD(P) transhydrogenase subunit beta (pyridine nucleotide transhydrogenase subunit beta; nicotinamide nucleotide transhydrogenase subunit beta) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.7.44 : NAD phosphorylation and dephosphorylation ; 1.6.1.2 TRANS-RXN0-277 NADPHOS-DEPHOS-PWY 2018-01-23 18:48:06 no The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 1 vladimir 0.227273 0.2929 0.25974 0.220058 0.55267 0.44733 0.274892 0.162338 0.400433 0.162338 0.562771 0.437229 0.233766 0.24026 0.15368 0.372294 0.393939 0.606061 0.17316 0.47619 0.225108 0.125541 0.701299 0.298701 0.715117 48514.54 0.60282 0.338395 0.555315 0.284165 0.101952 0.668113 0.331887 0.158351 0.078091 0.08026 5.386559 8.726681 NMV_1408 2192370 CDS -3 1382274 1382741 468 validated/Curated no putative NADPH-quinone dehydrogenase (modulator of drug activity B) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.6.5.10 NQOR-RXN$RXN0-271 2018-01-22 18:34:14 no 1 vladimir 0.279915 0.2051 0.273504 0.241453 0.478632 0.521368 0.25641 0.173077 0.358974 0.211538 0.532051 0.467949 0.358974 0.160256 0.179487 0.301282 0.339744 0.660256 0.224359 0.282051 0.282051 0.211538 0.564103 0.435897 0.706188 17799.67 -0.275484 0.23871 0.451613 0.2 0.187097 0.593548 0.406452 0.258065 0.135484 0.122581 5.76403 9.690323 NMV_1409 2192371 CDS -1 1383344 1383739 396 validated/Curated partial truncated TspB-like protein (N-terminal third of the protein) 5 : Unknown function f : factor 1 : Unknown 2018-01-23 18:48:57 no 16769696 Is part of a truncated filamentous bacteriophage, together with the six upstream genes. 1 vladimir 0.337748 0.2141 0.207506 0.240618 0.421634 0.578366 0.350993 0.099338 0.350993 0.198675 0.450331 0.549669 0.311258 0.278146 0.125828 0.284768 0.403974 0.596027 0.350993 0.264901 0.145695 0.238411 0.410596 0.589404 0.546344 16221.055 -0.02 0.353333 0.54 0.226667 0.106667 0.546667 0.453333 0.233333 0.153333 0.08 9.667564 8.58 NMV_1410 2192372 CDS -3 1383723 1384040 318 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2018-01-23 18:49:11 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 3 vladimir 0.324324 0.1321 0.195195 0.348348 0.327327 0.672673 0.333333 0.108108 0.261261 0.297297 0.369369 0.630631 0.387387 0.162162 0.117117 0.333333 0.279279 0.720721 0.252252 0.126126 0.207207 0.414414 0.333333 0.666667 0.605655 12998.415 -0.230909 0.209091 0.418182 0.2 0.181818 0.509091 0.490909 0.272727 0.145455 0.127273 6.890358 8.663636 NMV_1412 2192374 CDS -2 1384168 1384446 279 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2018-01-23 18:49:22 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 1 vladimir 0.297491 0.2043 0.25448 0.243728 0.458781 0.541219 0.290323 0.215054 0.27957 0.215054 0.494624 0.505376 0.344086 0.11828 0.204301 0.333333 0.322581 0.677419 0.258065 0.27957 0.27957 0.182796 0.55914 0.44086 0.512297 10504.855 -0.079348 0.217391 0.423913 0.282609 0.119565 0.586957 0.413043 0.217391 0.130435 0.086957 8.957588 8.858696 NMV_1413 2192375 CDS -2 1384453 1384737 285 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 1 : Unknown 2018-01-23 18:49:33 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 1 vladimir 0.273684 0.2281 0.242105 0.25614 0.470175 0.529825 0.315789 0.115789 0.4 0.168421 0.515789 0.484211 0.252632 0.305263 0.115789 0.326316 0.421053 0.578947 0.252632 0.263158 0.210526 0.273684 0.473684 0.526316 0.733066 10002.515 0.446809 0.351064 0.531915 0.223404 0.106383 0.670213 0.329787 0.212766 0.159574 0.053191 10.085945 8.925532 NMV_1414 2192376 CDS -1 1384745 1384942 198 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2018-01-23 18:49:43 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 3 vladimir 0.30303 0.2121 0.212121 0.272727 0.424242 0.575758 0.227273 0.106061 0.393939 0.272727 0.5 0.5 0.393939 0.166667 0.106061 0.333333 0.272727 0.727273 0.287879 0.363636 0.136364 0.212121 0.5 0.5 0.665281 7377.93 -0.058462 0.246154 0.476923 0.230769 0.184615 0.569231 0.430769 0.230769 0.061538 0.169231 4.05323 9.292308 NMV_1415 2192377 CDS -3 1384947 1385291 345 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-23 18:49:57 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. 2 vladimir 0.324638 0.2667 0.208696 0.2 0.475362 0.524638 0.33913 0.191304 0.295652 0.173913 0.486957 0.513043 0.33913 0.165217 0.208696 0.286957 0.373913 0.626087 0.295652 0.443478 0.121739 0.13913 0.565217 0.434783 0.660135 12551.805 -0.363158 0.298246 0.482456 0.210526 0.087719 0.508772 0.491228 0.210526 0.131579 0.078947 9.469215 9.035088 NMV_1416 2192378 fCDS -1 1385282 1385605 324 validated/Curated pseudo putative phage replication initiation factor (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 16:22:28 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. Homologous to the replication initiation factor (REP) initiating phage replication. This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the phage DNA at the origin of replication. 2 vladimir 0.342424 0.2394 0.184848 0.233333 0.424242 0.575758 0.263636 0.236364 0.272727 0.227273 0.509091 0.490909 0.490909 0.190909 0.081818 0.236364 0.272727 0.727273 0.272727 0.290909 0.2 0.236364 0.490909 0.509091 0.696457 12951.31 -0.766972 0.174312 0.348624 0.146789 0.201835 0.541284 0.458716 0.311927 0.174312 0.137615 7.121925 9.293578 NMV_1417 2192379 fCDS -2 1385602 1386315 714 validated/Curated pseudo putative phage replication initiation factor (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 16:22:13 no 16769696 Is part of a truncated filamentous bacteriophage, together with neighbouring genes. Homologous to the replication initiation factor (REP) initiating phage replication. This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the phage DNA at the origin of replication. 2 vladimir 0.291667 0.2325 0.252688 0.223118 0.485215 0.514785 0.25 0.157258 0.379032 0.21371 0.53629 0.46371 0.354839 0.177419 0.221774 0.245968 0.399194 0.600806 0.270161 0.362903 0.157258 0.209677 0.520161 0.479839 0.690288 28187.7 -0.6 0.287449 0.465587 0.165992 0.1417 0.510121 0.489879 0.323887 0.165992 0.157895 6.192665 9.797571 NMV_1418 2192380 CDS +2 1386767 1386940 174 validated/Curated partial truncated IS1016 group transposase (internal fragment corresponding to 25% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-01 17:35:25 no 3 vladimir 0.304598 0.1552 0.212644 0.327586 0.367816 0.632184 0.327586 0.224138 0.206897 0.241379 0.431034 0.568966 0.396552 0.086207 0.189655 0.327586 0.275862 0.724138 0.189655 0.155172 0.241379 0.413793 0.396552 0.603448 0.51984 6806.76 -0.410526 0.157895 0.350877 0.263158 0.192982 0.508772 0.491228 0.368421 0.263158 0.105263 9.666817 7.859649 NMV_1419 2192381 CDS -3 1387092 1388150 1059 validated/Curated no trpD anthranilate phosphoribosyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 2.4.2.18 ANTHRANSYN-RXN$PRTRANS-RXN TRPSYN-PWY 2018-01-23 18:51:07 no Catalyses the following reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate <=> anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. 1 vladimir 0.246459 0.2408 0.285175 0.227573 0.525968 0.474032 0.269122 0.186969 0.393768 0.150142 0.580737 0.419263 0.274788 0.243626 0.181303 0.300283 0.424929 0.575071 0.195467 0.291785 0.280453 0.232295 0.572238 0.427762 0.566437 37654.515 -0.048011 0.335227 0.525568 0.232955 0.065341 0.556818 0.443182 0.235795 0.122159 0.113636 6.040245 9.386364 NMV_1420 2192382 CDS -3 1388214 1388804 591 validated/Curated no trpG anthranilate synthase component II (glutamine amido-transferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 4.1.3.27 ANTHRANSYN-RXN TRPSYN-PWY 2018-01-23 18:51:53 no Catalyses the following reaction: chorismate + L-glutamine <=> anthranilate + pyruvate + L-glutamate. 1 vladimir 0.235195 0.2420 0.28088 0.241963 0.522843 0.477157 0.258883 0.213198 0.345178 0.182741 0.558376 0.441624 0.314721 0.192893 0.177665 0.314721 0.370558 0.629442 0.13198 0.319797 0.319797 0.228426 0.639594 0.360406 0.584098 21914.325 -0.132653 0.260204 0.47449 0.22449 0.132653 0.581633 0.418367 0.25 0.132653 0.117347 5.830681 10.005102 NMV_1423 2192385 CDS +1 1389226 1391502 2277 validated/Curated no putative TonB-dependent receptor 3 : Putative function from multiple computational evidences rc : receptor 1 : Unknown 2008-05-01 17:34:28 no 2 vladimir 0.264822 0.3140 0.238472 0.182697 0.552481 0.447519 0.235837 0.263505 0.330698 0.16996 0.594203 0.405797 0.362319 0.204216 0.200264 0.233202 0.40448 0.59552 0.196311 0.474308 0.184453 0.144928 0.658762 0.341238 0.693656 85069.575 -0.645515 0.279683 0.501319 0.193931 0.133245 0.506596 0.493404 0.271768 0.156992 0.114776 7.879646 9.594987 NMV_1425 2192387 CDS -2 1392334 1393131 798 validated/Curated no psd phosphatidylserine decarboxylase proenzyme [contains: phosphatidylserine decarboxylase alpha and beta chains] 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.6.1 : Phospholipid ; 4.1.1.65 PHOSPHASERDECARB-RXN PWY-5669 2018-01-23 18:52:42 no Catalyses the following reaction: phosphatidyl-L-serine <=> phosphatidylethanolamine + CO(2). 1 vladimir 0.20802 0.2381 0.294486 0.259398 0.532581 0.467419 0.210526 0.214286 0.390977 0.184211 0.605263 0.394737 0.259398 0.274436 0.172932 0.293233 0.447368 0.552632 0.154135 0.225564 0.319549 0.300752 0.545113 0.454887 0.739247 28999.17 0.006792 0.301887 0.554717 0.237736 0.086792 0.592453 0.407547 0.218868 0.113208 0.10566 6.938637 9.664151 NMV_1426 2192388 CDS +2 1393286 1396132 2847 validated/Curated no uvrA UvrABC system protein A (UvrA protein; excinuclease ABC subunit A) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2621 2018-01-23 18:53:09 no During the process of nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products. 2 vladimir 0.244117 0.3186 0.254303 0.183 0.572884 0.427116 0.244468 0.249737 0.356164 0.149631 0.605901 0.394099 0.320337 0.205479 0.193888 0.280295 0.399368 0.600632 0.167545 0.500527 0.212856 0.119073 0.713382 0.286617 0.682604 105361.555 -0.352532 0.280591 0.503165 0.232068 0.095992 0.521097 0.478903 0.283755 0.149789 0.133966 6.184227 9.579114 NMV_1428 2192390 CDS -1 1396349 1396546 198 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:33:52 no 3 vladimir 0.439394 0.1869 0.181818 0.191919 0.368687 0.631313 0.484848 0.181818 0.227273 0.106061 0.409091 0.590909 0.393939 0.227273 0.227273 0.151515 0.454545 0.545455 0.439394 0.151515 0.090909 0.318182 0.242424 0.757576 0.532256 7177.7 -1.266154 0.307692 0.538462 0.107692 0.046154 0.430769 0.569231 0.230769 0.153846 0.076923 9.992271 9.784615 NMV_1429 2192391 CDS -1 1396550 1396819 270 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 17:33:43 no 3 vladimir 0.348148 0.1593 0.181481 0.311111 0.340741 0.659259 0.311111 0.166667 0.288889 0.233333 0.455556 0.544444 0.355556 0.211111 0.155556 0.277778 0.366667 0.633333 0.377778 0.1 0.1 0.422222 0.2 0.8 0.489637 10132.09 -0.353933 0.280899 0.47191 0.202247 0.179775 0.516854 0.483146 0.247191 0.168539 0.078652 9.456291 9.022472 NMV_1430 2192392 CDS +1 1396957 1397898 942 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:23:38 no 3 vladimir 0.323308 0.1767 0.161654 0.338346 0.338346 0.661654 0.293233 0.191729 0.266917 0.24812 0.458647 0.541353 0.345865 0.214286 0.109023 0.330827 0.323308 0.676692 0.330827 0.12406 0.109023 0.43609 0.233083 0.766917 0.474165 30372.69 -0.183774 0.207547 0.456604 0.25283 0.135849 0.524528 0.475472 0.271698 0.14717 0.124528 6.337074 8.403774 NMV_1433 2192395 CDS +1 1398640 1398969 330 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:33:17 no 2 vladimir 0.293939 0.2879 0.20303 0.215152 0.490909 0.509091 0.254545 0.290909 0.236364 0.218182 0.527273 0.472727 0.390909 0.245455 0.154545 0.209091 0.4 0.6 0.236364 0.327273 0.218182 0.218182 0.545455 0.454545 0.648765 12852.23 -0.853211 0.247706 0.440367 0.165138 0.146789 0.458716 0.541284 0.321101 0.220183 0.100917 9.602303 9.678899 NMV_1434 2192396 CDS -2 1399204 1400094 891 validated/Curated no sucD succinate-CoA ligase [ADP-forming] alpha chain (succinyl-CoA synthetase alpha chain; SCS-alpha) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 6.2.1.5 SUCCCOASYN-RXN PWY-5913$TCA 2018-01-22 14:28:58 no Functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Catalyses the following reaction: ATP + succinate + CoA <=> ADP + phosphate + succinyl-CoA. 2 vladimir 0.261504 0.2649 0.251403 0.222222 0.516274 0.483726 0.306397 0.144781 0.417508 0.131313 0.56229 0.43771 0.265993 0.265993 0.181818 0.286195 0.447811 0.552189 0.212121 0.383838 0.154882 0.249158 0.538721 0.461279 0.856389 30590.885 0.067568 0.375 0.581081 0.236486 0.064189 0.608108 0.391892 0.202703 0.10473 0.097973 6.010765 9.25 NMV_1435 2192397 CDS -1 1400105 1401271 1167 validated/Curated no sucC succinate-CoA ligase [ADP-forming] beta chain (succinyl-CoA synthetase beta chain; SCS-beta) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 6.2.1.5 SUCCCOASYN-RXN PWY-5913$TCA 2018-01-22 14:29:15 no Functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Catalyses the following reaction: ATP + succinate + CoA <=> ADP + phosphate + succinyl-CoA. 2 vladimir 0.276778 0.2528 0.261354 0.209083 0.514139 0.485861 0.249357 0.156812 0.470437 0.123393 0.627249 0.372751 0.33162 0.200514 0.156812 0.311054 0.357326 0.642674 0.249357 0.401028 0.156812 0.192802 0.557841 0.442159 0.860989 41321.615 0.040722 0.298969 0.543814 0.260309 0.061856 0.595361 0.404639 0.252577 0.115979 0.136598 5.065804 9.559278 NMV_1436 2192398 CDS -2 1401370 1401657 288 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 17:32:28 no 1 vladimir 0.225694 0.1944 0.267361 0.3125 0.461806 0.538194 0.333333 0.15625 0.260417 0.25 0.416667 0.583333 0.1875 0.15625 0.21875 0.4375 0.375 0.625 0.15625 0.270833 0.322917 0.25 0.59375 0.40625 0.632384 10884.85 0.766316 0.263158 0.4 0.273684 0.157895 0.726316 0.273684 0.147368 0.105263 0.042105 9.696617 9.115789 NMV_1438 2192400 CDS -1 1401752 1403185 1434 validated/Curated no putative dihydrolipoyl dehydrogenase component of 2-oxoglutarate dehydrogenase complex (2-oxoglutarate dehydrogenase E3 component) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 4.S.11 : alpha-ketoglutarate ; 1.8.1.4 1.8.1.4-RXN$DIHYDLIPOXN-RXN$RXN-7716$RXN-7719$RXN-8629$RXN0-1132 GLYCLEAV-PWY$PWY-5084$PYRUVDEHYD-PWY 2018-01-29 18:47:41 no The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2 in the TCA cycle. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). E3 catalyses the following reaction: enzyme N(6)-(dihydrolipoyl)lysine + NAD(+) <=> enzyme N(6)-(lipoyl)lysine + NADH. 2 vladimir 0.264296 0.2601 0.26569 0.209902 0.525802 0.474198 0.261506 0.144351 0.468619 0.125523 0.612971 0.387029 0.301255 0.238494 0.169456 0.290795 0.40795 0.59205 0.230126 0.39749 0.158996 0.213389 0.556485 0.443515 0.84703 50135.12 0.047799 0.339623 0.568134 0.24109 0.083857 0.593291 0.406709 0.251572 0.129979 0.121593 5.904274 9.134172 NMV_1439 2192401 CDS -3 1403550 1404731 1182 validated/Curated no sucB dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (2-oxoglutarate dehydrogenase E2 component; dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 4.S.11 : alpha-ketoglutarate ; 2.3.1.61 2OXOGLUTARATEDEH-RXN$2OXOGLUTDECARB-RXN$RXN-7716$RXN0-1147 PWY-5084$TCA 2018-01-29 18:47:17 no The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2 in the TCA cycle. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). E2 catalyses the following reaction: succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine. 2 vladimir 0.251269 0.2690 0.254653 0.225042 0.523689 0.476311 0.238579 0.182741 0.469543 0.109137 0.652284 0.347716 0.281726 0.294416 0.126904 0.296954 0.42132 0.57868 0.233503 0.329949 0.167513 0.269036 0.497462 0.502538 0.838523 41499.14 0.105344 0.318066 0.564885 0.244275 0.050891 0.613232 0.386768 0.249364 0.117048 0.132316 5.138008 9.424936 NMV_1440 2192402 CDS -3 1404831 1407659 2829 validated/Curated no sucA 2-oxoglutarate dehydrogenase E1 component (alpha-ketoglutarate dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 4.S.11 : alpha-ketoglutarate ; 1.2.4.2 2OXOGLUTARATEDEH-RXN$2OXOGLUTDECARB-RXN$RXN-7716$RXN0-1147 PWY-5084$TCA 2018-01-29 18:46:51 no The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). E1 catalyses the following reaction reaction in the TCA cycle: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). 1 vladimir 0.261223 0.2623 0.251326 0.225168 0.513609 0.486391 0.2386 0.21527 0.367975 0.178155 0.583245 0.416755 0.338282 0.219512 0.173913 0.268293 0.393425 0.606575 0.206787 0.352068 0.212089 0.229056 0.564157 0.435843 0.782704 105162.245 -0.374098 0.282378 0.4862 0.207006 0.118896 0.537155 0.462845 0.278132 0.14862 0.129512 6.239983 9.546709 NMV_1441 2192403 CDS -3 1407864 1409147 1284 validated/Curated no gltA citrate synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 2.3.3.16 CITSYN-RXN ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:23:39 no Catalyses the first reaction in the TCA cycle: acetyl-CoA + H(2)O + oxaloacetate <=> citrate + CoA. 1 vladimir 0.229751 0.2671 0.259346 0.243769 0.52648 0.47352 0.240654 0.221963 0.320093 0.21729 0.542056 0.457944 0.301402 0.224299 0.17757 0.296729 0.401869 0.598131 0.147196 0.35514 0.280374 0.21729 0.635514 0.364486 0.727195 48066.4 -0.155504 0.278689 0.477752 0.213115 0.135831 0.583138 0.416862 0.245902 0.131148 0.114754 6.210503 9.676815 NMV_1442 2192404 CDS -3 1409259 1409507 249 validated/Curated no putative FAD assembly factor SdhE 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2020-02-21 16:12:40 no 24374335 SdhE is an FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays a key role in the assembly of succinate dehydrogenase, an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. 1 vladimir 0.305221 0.1807 0.240964 0.273092 0.421687 0.578313 0.277108 0.204819 0.301205 0.216867 0.506024 0.493976 0.361446 0.108434 0.156627 0.373494 0.26506 0.73494 0.277108 0.228916 0.26506 0.228916 0.493976 0.506024 0.543768 9794.015 -0.389024 0.158537 0.268293 0.243902 0.121951 0.47561 0.52439 0.402439 0.195122 0.207317 5.339775 9.036585 NMV_1443 2192405 CDS -3 1409511 1410218 708 validated/Curated no sdhB succinate dehydrogenase iron-sulfur subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.3.5.1 RXN0-5244$RXN0-5245$SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN PWY-3781$PWY-5913$TCA 2020-04-21 15:52:47 no Catalyses the following reaction in the TCA cycle: succinate + acceptor <=> fumarate + reduced acceptor. It is a complex consisting of two main components: a membrane-extrinsic component, composed of a FAD-binding flavoprotein and an iron-sulfur protein, and a hydrophobic component composed of a membrane anchor protein and a cytochrome b. 1 vladimir 0.248588 0.2316 0.242938 0.276836 0.474576 0.525424 0.262712 0.220339 0.288136 0.228814 0.508475 0.491525 0.347458 0.182203 0.186441 0.283898 0.368644 0.631356 0.135593 0.292373 0.254237 0.317797 0.54661 0.45339 0.798738 27085.3 -0.421277 0.221277 0.480851 0.221277 0.093617 0.53617 0.46383 0.297872 0.157447 0.140426 7.585808 10.110638 NMV_1444 2192406 CDS -3 1410339 1412102 1764 validated/Curated no sdhA succinate dehydrogenase flavoprotein subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.3.5.1 RXN0-5244$RXN0-5245$SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN PWY-3781$PWY-5913$TCA 2018-01-29 18:36:56 no Catalyses the following reaction in the TCA cycle: succinate + acceptor <=> fumarate + reduced acceptor. It is a complex consisting of two main components: a membrane-extrinsic component, composed of a FAD-binding flavoprotein and an iron-sulfur protein, and a hydrophobic component composed of a membrane anchor protein and a cytochrome b. 1 vladimir 0.239229 0.2404 0.28458 0.235828 0.524943 0.475057 0.232993 0.190476 0.420068 0.156463 0.610544 0.389456 0.312925 0.222789 0.19898 0.265306 0.421769 0.578231 0.171769 0.307823 0.234694 0.285714 0.542517 0.457483 0.807196 64488.56 -0.316865 0.306644 0.519591 0.202726 0.103918 0.555366 0.444634 0.289608 0.149915 0.139693 5.835487 10.005111 NMV_1445 2192407 CDS -1 1412105 1412446 342 validated/Curated no sdhD succinate dehydrogenase membrane anchor protein 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.3.5.1 RXN0-5244$RXN0-5245$SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN PWY-3781$PWY-5913$TCA 2018-01-29 18:38:36 no Catalyses the following reaction in the TCA cycle: succinate + acceptor <=> fumarate + reduced acceptor. It is a complex consisting of two main components: a membrane-extrinsic component, composed of a FAD-binding flavoprotein and an iron-sulfur protein, and a hydrophobic component composed of a membrane anchor protein and a cytochrome b. 1 vladimir 0.204678 0.1930 0.266082 0.336257 0.459064 0.540936 0.219298 0.157895 0.324561 0.298246 0.482456 0.517544 0.201754 0.184211 0.184211 0.429825 0.368421 0.631579 0.192982 0.236842 0.289474 0.280702 0.526316 0.473684 0.746874 13134.24 0.823894 0.247788 0.433628 0.327434 0.19469 0.707965 0.292035 0.150442 0.106195 0.044248 9.665001 8.849558 NMV_1446 2192408 CDS -2 1412440 1412817 378 validated/Curated no sdhC succinate dehydrogenase cytochrome b-556 subunit 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.3.5.1 RXN0-5244$RXN0-5245$SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN PWY-3781$PWY-5913$TCA 2018-01-29 18:38:55 no Catalyses the following reaction in the TCA cycle: succinate + acceptor <=> fumarate + reduced acceptor. It is a complex consisting of two main components: a membrane-extrinsic component, composed of a FAD-binding flavoprotein and an iron-sulfur protein, and a hydrophobic component composed of a membrane anchor protein and a cytochrome b. 1 vladimir 0.166667 0.2513 0.238095 0.343915 0.489418 0.510582 0.198413 0.261905 0.285714 0.253968 0.547619 0.452381 0.18254 0.246032 0.142857 0.428571 0.388889 0.611111 0.119048 0.246032 0.285714 0.349206 0.531746 0.468254 0.624303 13775 0.836 0.272 0.456 0.36 0.144 0.696 0.304 0.16 0.12 0.04 9.988213 8.032 NMV_1448 2192410 CDS -3 1413096 1414565 1470 validated/Curated no putative dihydrolipoyl dehydrogenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.8.1.4 1.8.1.4-RXN$DIHYDLIPOXN-RXN$RXN-7716$RXN-7719$RXN-8629$RXN0-1132 GLYCLEAV-PWY$PWY-5084$PYRUVDEHYD-PWY 2018-01-22 12:48:11 no 1 vladimir 0.22792 0.2585 0.287037 0.226496 0.545584 0.454416 0.230769 0.209402 0.42735 0.132479 0.636752 0.363248 0.301282 0.202991 0.181624 0.314103 0.384615 0.615385 0.151709 0.363248 0.252137 0.232906 0.615385 0.384615 0.774245 50773 -0.049251 0.280514 0.520343 0.246253 0.102784 0.588865 0.411135 0.263383 0.139186 0.124197 5.951591 9.492505 NMV_1449 2192411 CDS -1 1414748 1415485 738 validated/Curated no putative peroxiredoxin (thioredoxin reductase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.6.15.2 : Thioredoxin, glutaredoxin ; 1.11.1.15 2018-01-23 19:37:37 no Catalyses the following reaction: 2 R'-SH + ROOH <=> R'-S-S-R' + H(2)O + ROH. 2 vladimir 0.264228 0.2439 0.239837 0.252033 0.48374 0.51626 0.243902 0.130081 0.406504 0.219512 0.536585 0.463415 0.317073 0.235772 0.162602 0.284553 0.398374 0.601626 0.231707 0.365854 0.150407 0.252033 0.51626 0.48374 0.877684 26910.46 -0.22449 0.306122 0.55102 0.187755 0.110204 0.563265 0.436735 0.253061 0.110204 0.142857 4.796852 9.395918 NMV_1450 2192412 CDS -1 1415762 1418038 2277 validated/Curated no metE 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (methionine synthase, vitamin-B12 independent isozyme; cobalamin-independent methionine synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.9 : Methionine ; 1.7.20 : S-adenosyl methionine biosynthesis ; 2.1.1.14 HOMOCYSMET-RXN HOMOSER-METSYN-PWY$PWY-6151 2018-01-30 14:30:54 no Catalyses the last step in the production of methionine: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> tetrahydropteroyltri-L-glutamate + L-methionine. 2 vladimir 0.258235 0.2885 0.237154 0.216074 0.525692 0.474308 0.226614 0.222661 0.370224 0.180501 0.592885 0.407115 0.326746 0.239789 0.146245 0.28722 0.386034 0.613966 0.221344 0.403162 0.194993 0.180501 0.598155 0.401845 0.854148 84987.825 -0.194987 0.274406 0.478892 0.228232 0.113456 0.550132 0.449868 0.270449 0.131926 0.138522 5.384743 9.14248 NMV_1451 2192413 CDS -3 1418175 1419053 879 validated/Curated no metF 5,10-methylenetetrahydrofolate reductase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 1.5.1.20 1.5.1.20-RXN 1CMET2-PWY$PWY-2201 2018-01-23 19:38:47 no Catalyses the following reaction: 5-methyltetrahydrofolate + NAD(P)(+) <=> 5,10-methylenetetrahydrofolate + NAD(P)H. 1 vladimir 0.262799 0.2867 0.234357 0.216155 0.521047 0.478953 0.259386 0.221843 0.34471 0.174061 0.566553 0.433447 0.341297 0.201365 0.153584 0.303754 0.354949 0.645051 0.187713 0.43686 0.204778 0.170648 0.641638 0.358362 0.772227 33080.545 -0.285616 0.236301 0.479452 0.236301 0.116438 0.537671 0.462329 0.287671 0.150685 0.136986 6.105186 9.383562 NMV_1452 2192414 CDS +2 1419254 1419529 276 validated/Curated no rpmE2 50S ribosomal protein L31 type B 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-23 19:39:05 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.293478 0.2681 0.199275 0.23913 0.467391 0.532609 0.315217 0.195652 0.25 0.23913 0.445652 0.554348 0.347826 0.25 0.184783 0.217391 0.434783 0.565217 0.217391 0.358696 0.163043 0.26087 0.521739 0.478261 0.686898 10464.29 -0.849451 0.307692 0.527473 0.120879 0.153846 0.428571 0.571429 0.274725 0.175824 0.098901 9.46302 9.318681 NMV_1453 2192415 CDS +1 1419529 1419654 126 validated/Curated no rpmJ 50S ribosomal protein L36 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-23 19:39:20 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.293651 0.3095 0.214286 0.18254 0.52381 0.47619 0.309524 0.333333 0.190476 0.166667 0.52381 0.47619 0.309524 0.142857 0.309524 0.238095 0.452381 0.547619 0.261905 0.452381 0.142857 0.142857 0.595238 0.404762 0.681894 4942.7 -0.960976 0.219512 0.390244 0.195122 0.073171 0.414634 0.585366 0.365854 0.341463 0.02439 11.800377 10.341463 NMV_1455 2192417 CDS +3 1420122 1421261 1140 validated/Curated no metXS homoserine O-succinyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.9 : Methionine ; 2.3.1.46 HOMSUCTRAN-RXN HOMOSER-METSYN-PWY 2018-01-23 19:57:46 no Catalyses the following reaction: succinyl-CoA + L-homoserine <=> CoA + O-succinyl-L-homoserine. Requires MetW for activity. 1 vladimir 0.235965 0.2509 0.280702 0.232456 0.531579 0.468421 0.236842 0.189474 0.376316 0.197368 0.565789 0.434211 0.323684 0.218421 0.189474 0.268421 0.407895 0.592105 0.147368 0.344737 0.276316 0.231579 0.621053 0.378947 0.700623 42036.84 -0.266491 0.300792 0.522427 0.192612 0.137203 0.575198 0.424802 0.234828 0.124011 0.110818 6.088097 9.810026 NMV_1456 2192418 CDS +2 1421258 1421839 582 validated/Curated no putative methionine biosynthesis protein MetW 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-23 20:08:12 no Required for MetXS activity. 1 vladimir 0.256014 0.2698 0.256014 0.218213 0.525773 0.474227 0.278351 0.221649 0.324742 0.175258 0.546392 0.453608 0.314433 0.14433 0.216495 0.324742 0.360825 0.639175 0.175258 0.443299 0.226804 0.154639 0.670103 0.329897 0.702141 21829.28 -0.085492 0.248705 0.481865 0.253886 0.108808 0.569948 0.430052 0.238342 0.129534 0.108808 6.569496 9.906736 NMV_1457 2192419 CDS +1 1421956 1422801 846 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 17:27:27 no 2 vladimir 0.277778 0.3085 0.224586 0.189125 0.533097 0.466903 0.248227 0.280142 0.294326 0.177305 0.574468 0.425532 0.351064 0.258865 0.163121 0.22695 0.421986 0.578014 0.234043 0.386525 0.216312 0.163121 0.602837 0.397163 0.615197 31415.03 -0.67153 0.291815 0.480427 0.174377 0.096085 0.483986 0.516014 0.274021 0.142349 0.131673 5.939949 9.47331 NMV_1458 2192420 CDS -1 1422851 1423411 561 validated/Curated no efp elongation factor P (EF-P) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2020-04-22 13:34:54 no Involved in peptide bond synthesis. Stimulates efficient translation. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. 2 vladimir 0.304813 0.2781 0.229947 0.187166 0.508021 0.491979 0.320856 0.13369 0.395722 0.149733 0.529412 0.470588 0.363636 0.197861 0.144385 0.294118 0.342246 0.657754 0.229947 0.502674 0.149733 0.117647 0.652406 0.347594 0.858545 20892.965 -0.342473 0.268817 0.5 0.204301 0.091398 0.521505 0.478495 0.290323 0.123656 0.166667 4.767159 10 NMV_1459 2192421 CDS -1 1423454 1424602 1149 validated/Curated no earP EF-P rhamnosyl modification enzyme 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-02-24 14:05:23 no 26840407, 29440735 Is a glycosyltransferase that rhamnosylates EF-P, which is important for its activity. 1 vladimir 0.21671 0.2811 0.2698 0.232376 0.550914 0.449086 0.185379 0.289817 0.331593 0.193211 0.62141 0.37859 0.318538 0.190601 0.208877 0.281984 0.399478 0.600522 0.146214 0.362924 0.26893 0.221932 0.631854 0.368146 0.633474 44061.365 -0.310209 0.243455 0.468586 0.21466 0.157068 0.552356 0.447644 0.274869 0.141361 0.133508 5.639702 9.41623 NMV_1460 2192422 CDS -1 1424621 1424899 279 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-19 18:27:02 no 1 vladimir 0.190939 0.2621 0.20712 0.339806 0.469256 0.530744 0.223301 0.252427 0.252427 0.271845 0.504854 0.495146 0.242718 0.174757 0.097087 0.485437 0.271845 0.728155 0.106796 0.359223 0.271845 0.262136 0.631068 0.368932 0.64794 11860.935 0.918627 0.186275 0.382353 0.333333 0.196078 0.696078 0.303922 0.186275 0.117647 0.068627 7.948647 8.460784 NMV_1461 2192423 CDS +2 1425401 1426342 942 validated/Curated no miaA tRNA dimethylallyltransferase (tRNA delta(2)-isopentenylpyrophosphate transferase;IPP transferase; isopentenyl-diphosphate:tRNA isopentenyltransferase; IPTase; IPPT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.5.1.75 RXN0-6274 2018-01-19 10:32:58 no Catalyses the following reaction: dimethylallyl diphosphate + adenine(37) in tRNA <=> diphosphate + N(6)-dimethylallyladenine(37) in tRNA. 2 vladimir 0.22293 0.3301 0.240977 0.205945 0.571125 0.428875 0.232484 0.280255 0.328025 0.159236 0.60828 0.39172 0.264331 0.273885 0.187898 0.273885 0.461783 0.538217 0.171975 0.436306 0.207006 0.184713 0.643312 0.356688 0.715224 34759.98 -0.157188 0.316294 0.498403 0.207668 0.102236 0.578275 0.421725 0.258786 0.146965 0.111821 8.577232 9.741214 NMV_1462 2192424 CDS +2 1426346 1427065 720 validated/Curated no tadA tRNA-specific adenosine deaminase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 3.5.4.33 RXN0-1081 2018-01-23 13:54:13 no The enzyme is involved in editing of tRNA: adenine(34) in tRNA + H(2)O <=> hypoxanthine(34) in tRNA + NH(3). 2 vladimir 0.263889 0.3250 0.245833 0.165278 0.570833 0.429167 0.258333 0.275 0.333333 0.133333 0.608333 0.391667 0.283333 0.270833 0.175 0.270833 0.445833 0.554167 0.25 0.429167 0.229167 0.091667 0.658333 0.341667 0.6206 25962.95 -0.053138 0.338912 0.497908 0.221757 0.075314 0.564854 0.435146 0.230126 0.129707 0.100418 7.17202 9.514644 NMV_1463 2192425 CDS +3 1427070 1427558 489 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 17:26:15 no 2 vladimir 0.175869 0.2883 0.284254 0.251534 0.572597 0.427403 0.239264 0.177914 0.392638 0.190184 0.570552 0.429448 0.116564 0.226994 0.220859 0.435583 0.447853 0.552147 0.171779 0.460123 0.239264 0.128834 0.699387 0.300613 0.536816 16580.455 1.39321 0.388889 0.493827 0.364198 0.111111 0.845679 0.154321 0.067901 0.049383 0.018519 9.562355 8.179012 NMV_1464 2192426 CDS +2 1427624 1428376 753 validated/Curated no rlmB 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB (23S rRNA Gm2251 2'-O-methyltransferase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.185 RXN-11588 2018-01-22 18:47:28 no This enzyme catalyses the methylation of guanosine(2251), a modification conserved in the peptidyltransferase domain of 23S rRNA. 2 vladimir 0.26826 0.3121 0.256308 0.163347 0.568393 0.431607 0.2749 0.211155 0.390438 0.123506 0.601594 0.398406 0.306773 0.215139 0.195219 0.282869 0.410359 0.589641 0.223108 0.50996 0.183267 0.083665 0.693227 0.306773 0.713608 27378.115 -0.1792 0.3 0.54 0.232 0.084 0.556 0.444 0.264 0.14 0.124 6.082222 9.996 NMV_1465 2192427 CDS -3 1428438 1429829 1392 validated/Curated no putative xanthine permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-23 20:21:47 no Specific, proton motive force-dependent high-affinity transporter for xanthine. 1 vladimir 0.153736 0.2263 0.341954 0.278017 0.568247 0.431753 0.230603 0.159483 0.403017 0.206897 0.5625 0.4375 0.165948 0.241379 0.172414 0.420259 0.413793 0.586207 0.064655 0.278017 0.450431 0.206897 0.728448 0.271552 0.666531 48308.19 0.869546 0.336933 0.561555 0.321814 0.099352 0.710583 0.289417 0.136069 0.073434 0.062635 6.261559 8.613391 NMV_1467 2192429 CDS +3 1430136 1431011 876 validated/Curated no dapA 4-hydroxy-tetrahydrodipicolinate synthase (dihydrodipicolinate synthase; DHDPS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 4.3.3.7 DIHYDRODIPICSYN-RXN DAPLYSINESYN-PWY 2018-01-19 10:34:28 no Catalyses the following reaction: pyruvate + L-aspartate-4-semialdehyde <=> (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O. It is the key enzyme in lysine biosynthesis via the diaminopimelate pathway. 2 vladimir 0.236301 0.3584 0.244292 0.160959 0.60274 0.39726 0.256849 0.229452 0.414384 0.099315 0.643836 0.356164 0.267123 0.273973 0.160959 0.297945 0.434932 0.565068 0.184932 0.571918 0.157534 0.085616 0.729452 0.270548 0.701276 30847.19 0.164948 0.329897 0.570447 0.254296 0.075601 0.618557 0.381443 0.206186 0.103093 0.103093 5.492302 9.697595 NMV_1468 2192430 CDS +2 1431089 1432216 1128 validated/Curated no bamC outer membrane protein assembly factor BamC 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 8 : Outer membrane-associated 2018-01-30 16:45:56 no Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. 1 vladimir 0.257979 0.3324 0.248227 0.161348 0.580674 0.419326 0.239362 0.257979 0.375 0.12766 0.632979 0.367021 0.329787 0.228723 0.191489 0.25 0.420213 0.579787 0.204787 0.510638 0.178191 0.106383 0.68883 0.31117 0.713796 41298.34 -0.482133 0.285333 0.498667 0.208 0.082667 0.533333 0.466667 0.282667 0.157333 0.125333 9.132439 9.234667 NMV_1469 2192431 CDS -2 1432273 1433205 933 validated/Curated no pip proline iminopeptidase (PIP; prolyl aminopeptidase; PAP) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.4.11.5 3.4.11.5-RXN 2018-01-23 20:27:16 no Catalyses the release of N-terminal proline from a peptide. 1 vladimir 0.207931 0.2036 0.325831 0.262594 0.529475 0.470525 0.189711 0.21865 0.369775 0.221865 0.588424 0.411576 0.299035 0.205788 0.215434 0.279743 0.421222 0.578778 0.135048 0.186495 0.392283 0.286174 0.578778 0.421222 0.607192 35026.515 -0.175161 0.264516 0.470968 0.229032 0.141935 0.6 0.4 0.254839 0.125806 0.129032 5.408134 9.864516 NMV_1469.1 2610206 fCDS +1 1434847 1434960 114 validated/Curated pseudo opaD opacity protein D (pseudogene part 1) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-23 20:27:31 Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. vladimir NMV_1470 2192432 fCDS +3 1434963 1435637 675 validated/Curated pseudo opaD opacity protein D (pseudogene part 2) 1c : Function from experimental evidences in the studied genus m : membrane component 8 : Outer membrane-associated 2018-01-23 20:27:44 no Belongs to the family of phase-variable opacity proteins that mediate pathogen/host cell interactions. 2 vladimir 0.296296 0.2785 0.223704 0.201481 0.502222 0.497778 0.324444 0.177778 0.306667 0.191111 0.484444 0.515556 0.368889 0.222222 0.195556 0.213333 0.417778 0.582222 0.195556 0.435556 0.168889 0.2 0.604444 0.395556 0.61778 25322.295 -0.727679 0.299107 0.522321 0.169643 0.169643 0.477679 0.522321 0.290179 0.191964 0.098214 9.520699 9.232143 NMV_1471 2192433 CDS +3 1436736 1437182 447 validated/Curated no putative acyl-CoA thioester hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.2.- PALMITOYL-COA-HYDROLASE-RXN 2018-01-23 10:56:09 no Belongs to the thioesterase superfamily. 1 vladimir 0.234899 0.2953 0.266219 0.203579 0.561521 0.438479 0.248322 0.241611 0.375839 0.134228 0.61745 0.38255 0.288591 0.201342 0.194631 0.315436 0.395973 0.604027 0.167785 0.442953 0.228188 0.161074 0.671141 0.328859 0.723489 16276.125 -0.078378 0.256757 0.540541 0.256757 0.067568 0.594595 0.405405 0.216216 0.108108 0.108108 5.58416 10.574324 NMV_1472 2192434 CDS -1 1437233 1438054 822 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-01 17:16:35 no 1 vladimir 0.225061 0.2141 0.317518 0.243309 0.53163 0.46837 0.251825 0.145985 0.405109 0.19708 0.551095 0.448905 0.281022 0.222628 0.193431 0.30292 0.416058 0.583942 0.142336 0.273723 0.354015 0.229927 0.627737 0.372263 0.646937 30118.22 -0.070696 0.304029 0.512821 0.212454 0.098901 0.589744 0.410256 0.245421 0.113553 0.131868 5.097527 10.03663 NMV_1473 2192435 CDS +3 1438173 1438631 459 validated/Curated no cytochrome c' 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 11 : Membrane 2018-01-31 14:32:39 no Cytochrome c' is the most widely occurring bacterial c-type cytochrome. Cytochromes c' are high-spin proteins and the heme has no sixth ligand. Their exact function is not known. 2 vladimir 0.294118 0.3181 0.228758 0.159041 0.546841 0.453159 0.281046 0.169935 0.398693 0.150327 0.568627 0.431373 0.313726 0.320261 0.163399 0.202614 0.48366 0.51634 0.287582 0.464052 0.124183 0.124183 0.588235 0.411765 0.731719 16174.715 -0.392105 0.401316 0.539474 0.111842 0.085526 0.539474 0.460526 0.269737 0.138158 0.131579 6.887367 8.967105 NMV_1474 2192436 CDS -2 1438795 1439910 1116 validated/Curated no lst N-acetyllactosaminide alpha-2,3-sialyltransferase (beta-galactoside alpha-2,3-sialyltransferase; alpha 2,3-ST: lipooligosaccharide sialyltransferase) 1b : Function from experimental evidences in the studied species e : enzyme 5 : Inner membrane protein 2.4.99.6 2.4.99.6-RXN 2020-04-21 15:55:44 no 8910446 Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide. 1 vladimir 0.273297 0.2061 0.263441 0.257168 0.469534 0.530466 0.322581 0.163978 0.293011 0.22043 0.456989 0.543011 0.352151 0.201613 0.137097 0.30914 0.33871 0.66129 0.145161 0.252688 0.360215 0.241935 0.612903 0.387097 0.556848 42536.51 -0.234501 0.245283 0.450135 0.212938 0.145553 0.555256 0.444744 0.261456 0.142857 0.118598 8.406868 9.256065 NMV_1476 2192438 CDS +2 1440344 1442569 2226 validated/Curated no icd isocitrate dehydrogenase [NADP] (oxalosuccinate decarboxylase; IDH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.1.1.42 ISOCITDEH-RXN$ISOCITRATE-DEHYDROGENASE-NAD+-RXN$R23-RXN$RXN-8642$RXN-9951 ANARESP1-PWY$FERMENTATION-PWY$P105-PWY$PWY-5913$TCA 2018-01-31 15:25:58 no Catalyses the fourth reaction in the TCA cycle: isocitrate + NADP(+) <=> 2-oxoglutarate + CO(2) + NADPH. 2 vladimir 0.265499 0.3010 0.242138 0.191375 0.543127 0.456873 0.256065 0.208895 0.409703 0.125337 0.618598 0.381402 0.326146 0.277628 0.125337 0.270889 0.402965 0.597035 0.214286 0.416442 0.191375 0.177898 0.607817 0.392183 0.790084 80016.72 -0.188664 0.31444 0.551957 0.207827 0.087719 0.553306 0.446694 0.25776 0.129555 0.128205 5.63073 9.102564 NMV_1477 2192439 CDS +3 1442712 1443020 309 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-01 17:15:46 no 2 vladimir 0.304207 0.3010 0.190939 0.203883 0.491909 0.508091 0.359223 0.242718 0.252427 0.145631 0.495146 0.504854 0.31068 0.281553 0.145631 0.262136 0.427184 0.572816 0.242718 0.378641 0.174757 0.203883 0.553398 0.446602 0.702561 11304.725 -0.252941 0.323529 0.5 0.166667 0.088235 0.529412 0.470588 0.22549 0.147059 0.078431 9.334526 9.147059 NMNmiscRNA0151 54907925 misc_RNA -1 1442984 1443262 279 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 11:03:00 28334889 Function unknown. vladimir NMV_1478 2192440 CDS +2 1443641 1443772 132 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 12:50:19 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_1479) encodes the cognate toxin. 2 vladimir 0.340909 0.3258 0.204545 0.128788 0.530303 0.469697 0.318182 0.295455 0.363636 0.022727 0.659091 0.340909 0.363636 0.25 0.159091 0.227273 0.409091 0.590909 0.340909 0.431818 0.090909 0.136364 0.522727 0.477273 0.670072 4752.43 -0.632558 0.27907 0.44186 0.209302 0.023256 0.488372 0.511628 0.348837 0.27907 0.069767 11.13398 9.302326 NMV_1479 2192441 CDS +1 1443769 1444137 369 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 12:50:32 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_1478) encodes the cognate antitoxin. 1 vladimir 0.241192 0.2710 0.292683 0.195122 0.563686 0.436314 0.227642 0.219512 0.414634 0.138211 0.634146 0.365854 0.333333 0.227642 0.146341 0.292683 0.373984 0.626016 0.162602 0.365854 0.317073 0.154472 0.682927 0.317073 0.540589 13386.735 -0.031148 0.303279 0.459016 0.254098 0.07377 0.57377 0.42623 0.278689 0.114754 0.163934 4.595299 9.295082 NMV_1481 2192443 CDS +1 1444267 1444503 237 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 12:50:43 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_1482) encodes the cognate toxin. 3 vladimir 0.227848 0.2447 0.312236 0.21519 0.556962 0.443038 0.151899 0.227848 0.468354 0.151899 0.696203 0.303797 0.291139 0.177215 0.202532 0.329114 0.379747 0.620253 0.240506 0.329114 0.265823 0.164557 0.594937 0.405063 0.720534 8825.815 -0.194872 0.205128 0.474359 0.269231 0.064103 0.576923 0.423077 0.333333 0.153846 0.179487 5.066765 10.435897 NMV_1482 2192444 CDS +2 1444505 1444852 348 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 12:50:55 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_1481) encodes the cognate antitoxin. 1 vladimir 0.241379 0.2615 0.255747 0.241379 0.517241 0.482759 0.241379 0.198276 0.353448 0.206897 0.551724 0.448276 0.275862 0.25 0.189655 0.284483 0.439655 0.560345 0.206897 0.336207 0.224138 0.232759 0.560345 0.439655 0.60455 12353.61 -0.01913 0.347826 0.547826 0.208696 0.113043 0.582609 0.417391 0.226087 0.130435 0.095652 7.999062 8.626087 NMV_1483 2192445 CDS -3 1444905 1445414 510 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 17:14:47 no 1 vladimir 0.278431 0.2627 0.266667 0.192157 0.529412 0.470588 0.217647 0.217647 0.405882 0.158824 0.623529 0.376471 0.341176 0.288235 0.176471 0.194118 0.464706 0.535294 0.276471 0.282353 0.217647 0.223529 0.5 0.5 0.587769 18797.45 -0.501775 0.35503 0.461538 0.153846 0.106509 0.526627 0.473373 0.289941 0.159763 0.130178 8.105232 9.928994 NMV_1485 2192447 CDS -1 1445426 1445899 474 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:14:36 no 1 vladimir 0.265823 0.2911 0.263713 0.179325 0.554852 0.445148 0.278481 0.272152 0.310127 0.139241 0.582278 0.417722 0.297468 0.234177 0.221519 0.246835 0.455696 0.544304 0.221519 0.367089 0.259494 0.151899 0.626582 0.373418 0.645074 17511.33 -0.519108 0.299363 0.496815 0.184713 0.095541 0.515924 0.484076 0.267516 0.165605 0.101911 9.557442 9.751592 NMV_1486 2192448 CDS +2 1446047 1446427 381 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:14:24 no 2 vladimir 0.304462 0.2625 0.24147 0.191601 0.503937 0.496063 0.283465 0.23622 0.314961 0.165354 0.551181 0.448819 0.330709 0.212598 0.181102 0.275591 0.393701 0.606299 0.299213 0.338583 0.228346 0.133858 0.566929 0.433071 0.548317 14375.305 -0.42619 0.222222 0.492063 0.206349 0.103175 0.555556 0.444444 0.309524 0.198413 0.111111 9.389534 9.944444 NMNmiscRNA0168 54919401 misc_RNA +1 1446438 1446632 195 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 12:56:45 28334889 Function unknown. Very abundant RNA. vladimir NMV_1487 2192449 CDS -1 1446632 1446781 150 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:24:28 no 1 vladimir 0.293333 0.1867 0.293333 0.226667 0.48 0.52 0.26 0.12 0.38 0.24 0.5 0.5 0.4 0.18 0.2 0.22 0.38 0.62 0.22 0.26 0.3 0.22 0.56 0.44 0.596335 5865.41 -0.763265 0.244898 0.408163 0.122449 0.142857 0.489796 0.510204 0.367347 0.183673 0.183673 6.382469 10.857143 NMV_1488 2192450 CDS -2 1446784 1447458 675 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:24:56 no 1 vladimir 0.177778 0.2148 0.357037 0.25037 0.571852 0.428148 0.177778 0.226667 0.395556 0.2 0.622222 0.377778 0.302222 0.235556 0.208889 0.253333 0.444444 0.555556 0.053333 0.182222 0.466667 0.297778 0.648889 0.351111 0.540714 25467.685 -0.403125 0.272321 0.513393 0.196429 0.138393 0.558036 0.441964 0.3125 0.142857 0.169643 4.956322 10.209821 NMV_1489 2192451 CDS -3 1447455 1447862 408 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:26:13 no 1 vladimir 0.220588 0.1667 0.365196 0.247549 0.531863 0.468137 0.191176 0.154412 0.492647 0.161765 0.647059 0.352941 0.367647 0.169118 0.176471 0.286765 0.345588 0.654412 0.102941 0.176471 0.426471 0.294118 0.602941 0.397059 0.607778 15041.51 -0.234074 0.266667 0.474074 0.22963 0.096296 0.555556 0.444444 0.333333 0.162963 0.17037 5.425011 10.059259 NMV_1490 2192452 CDS -1 1447946 1448419 474 validated/Curated no putative phage structural protein 3 : Putative function from multiple computational evidences s : structure 1 : Unknown 2008-05-01 17:13:31 no 1 vladimir 0.185654 0.2194 0.335443 0.259494 0.554852 0.445148 0.221519 0.14557 0.468354 0.164557 0.613924 0.386076 0.303797 0.272152 0.14557 0.278481 0.417722 0.582278 0.031646 0.240506 0.392405 0.335443 0.632911 0.367089 0.659286 16404.96 0.115924 0.356688 0.592357 0.22293 0.089172 0.630573 0.369427 0.22293 0.10828 0.11465 5.272163 9.121019 NMV_1491 2192453 CDS -1 1448477 1449772 1296 validated/Curated no putative phage structural protein 3 : Putative function from multiple computational evidences s : structure 1 : Unknown 2008-05-01 17:11:37 no 1 vladimir 0.195216 0.2353 0.333333 0.236111 0.568673 0.431327 0.25 0.210648 0.386574 0.152778 0.597222 0.402778 0.275463 0.259259 0.189815 0.275463 0.449074 0.550926 0.060185 0.236111 0.423611 0.280093 0.659722 0.340278 0.672876 46636.33 -0.238051 0.320186 0.556845 0.183295 0.090487 0.580046 0.419954 0.227378 0.12529 0.102088 8.702202 9.791183 NMV_1492 2192454 CDS -2 1449793 1450704 912 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:40:51 no 1 vladimir 0.254386 0.2149 0.345395 0.185307 0.560307 0.439693 0.213816 0.177632 0.5 0.108553 0.677632 0.322368 0.424342 0.282895 0.118421 0.174342 0.401316 0.598684 0.125 0.184211 0.417763 0.273026 0.601974 0.398026 0.554818 32666.3 -0.891749 0.306931 0.544554 0.145215 0.059406 0.465347 0.534653 0.39604 0.145215 0.250825 4.400261 9.306931 NMV_1493 2192455 CDS -2 1450789 1451982 1194 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:11:06 no 1 vladimir 0.137353 0.1993 0.407873 0.255444 0.607203 0.392797 0.155779 0.18593 0.477387 0.180905 0.663317 0.336683 0.203518 0.253769 0.226131 0.316583 0.479899 0.520101 0.052764 0.158291 0.5201 0.268844 0.678392 0.321608 0.524045 41813.2 0.233249 0.347607 0.61461 0.239295 0.095718 0.657431 0.342569 0.219144 0.11335 0.105793 5.855675 9.826196 NMV_1494 2192456 CDS -3 1451970 1455176 3207 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:10:55 no 1 vladimir 0.152791 0.2348 0.378859 0.233552 0.613658 0.386342 0.178672 0.232928 0.388213 0.200187 0.621141 0.378859 0.21609 0.242283 0.266604 0.275023 0.508887 0.491113 0.063611 0.229186 0.481759 0.225444 0.710945 0.289055 0.492307 118434.915 -0.252996 0.310861 0.560861 0.182584 0.148876 0.613296 0.386704 0.225655 0.144195 0.081461 10.433083 10.077715 NMV_1495 2192457 CDS -1 1455188 1455580 393 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:10:44 no 1 vladimir 0.195929 0.2010 0.379135 0.223919 0.580153 0.419847 0.198473 0.175573 0.458015 0.167939 0.633588 0.366412 0.29771 0.19084 0.236641 0.274809 0.427481 0.572519 0.091603 0.236641 0.442748 0.229008 0.679389 0.320611 0.499997 14172.455 -0.289231 0.284615 0.561538 0.207692 0.115385 0.607692 0.392308 0.292308 0.153846 0.138462 6.330559 10.015385 NMV_1496 2192458 CDS -2 1455580 1456479 900 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:10:34 no 1 vladimir 0.221111 0.2189 0.307778 0.252222 0.526667 0.473333 0.243333 0.176667 0.33 0.25 0.506667 0.493333 0.32 0.206667 0.226667 0.246667 0.433333 0.566667 0.1 0.273333 0.366667 0.26 0.64 0.36 0.55134 33788.37 -0.43612 0.317726 0.535117 0.177258 0.16388 0.531773 0.468227 0.240803 0.120401 0.120401 5.608513 9.438127 NMV_1497 2192459 CDS -1 1456472 1456897 426 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2015-11-19 18:25:53 no 1 vladimir 0.150641 0.1955 0.400641 0.253205 0.596154 0.403846 0.096154 0.153846 0.509615 0.240385 0.663462 0.336538 0.259615 0.317308 0.201923 0.221154 0.519231 0.480769 0.096154 0.115385 0.490385 0.298077 0.605769 0.394231 0.589994 10890.74 -0.125243 0.368932 0.640777 0.135922 0.116505 0.669903 0.330097 0.23301 0.07767 0.15534 4.243355 10.07767 NMV_1499 2192461 CDS -2 1456909 1457316 408 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:10:08 no 1 vladimir 0.213235 0.2108 0.328431 0.247549 0.539216 0.460784 0.330882 0.132353 0.345588 0.191176 0.477941 0.522059 0.25 0.323529 0.132353 0.294118 0.455882 0.544118 0.058824 0.176471 0.507353 0.257353 0.683824 0.316176 0.515902 14394.57 0.02 0.385185 0.644444 0.22963 0.088889 0.511111 0.488889 0.177778 0.074074 0.103704 4.553749 8.62963 NMV_1500 2192462 CDS -2 1457419 1465845 8427 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-24 15:06:22 no Longest gene in the genome. 1 vladimir 0.204106 0.2154 0.362763 0.217752 0.578142 0.421858 0.211107 0.180135 0.459594 0.149163 0.639729 0.360271 0.303667 0.272339 0.188679 0.235315 0.461018 0.538982 0.097544 0.193663 0.440014 0.268779 0.633677 0.366323 0.566912 299909.555 -0.354487 0.347578 0.558048 0.187322 0.075499 0.555556 0.444444 0.285969 0.151709 0.134259 7.900261 9.557692 NMV_1501 2192463 CDS -1 1465802 1466218 417 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:41:37 no 1 vladimir 0.235012 0.1679 0.398082 0.199041 0.565947 0.434053 0.201439 0.151079 0.482014 0.165468 0.633094 0.366906 0.374101 0.158273 0.273381 0.194245 0.431655 0.568345 0.129496 0.194245 0.438849 0.23741 0.633094 0.366906 0.528074 15253.315 -0.888406 0.318841 0.485507 0.144928 0.07971 0.514493 0.485507 0.362319 0.166667 0.195652 5.039314 10.086957 NMV_1502 2192464 CDS -2 1466215 1467411 1197 validated/Curated no conserved hypothetical phage protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-23 16:41:57 no 1 vladimir 0.213033 0.1721 0.410192 0.204678 0.582289 0.417711 0.230576 0.185464 0.458647 0.125313 0.64411 0.35589 0.365915 0.233083 0.203008 0.197995 0.43609 0.56391 0.042607 0.097744 0.568922 0.290727 0.666667 0.333333 0.444542 43990.165 -0.886683 0.30402 0.497487 0.138191 0.065327 0.484925 0.515075 0.356784 0.175879 0.180905 5.726646 10.482412 NMV_1503 2192465 CDS -3 1467675 1468871 1197 validated/Curated no putative phage integrase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-23 16:42:14 no 1 vladimir 0.204678 0.1863 0.371763 0.23726 0.558062 0.441938 0.235589 0.22807 0.360902 0.175439 0.588972 0.411028 0.290727 0.200501 0.230576 0.278196 0.431078 0.568922 0.087719 0.130326 0.52381 0.258145 0.654135 0.345865 0.475046 45638.715 -0.451005 0.258794 0.464824 0.213568 0.103015 0.530151 0.469849 0.298995 0.183417 0.115578 10.110405 10.057789 NMV_tRNA_50 2194865 tRNA -1 1469063 1469152 90 validated/Curated no Ser tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:55:27 no tRNA Ser anticodon CGA. vladimir NMV_tRNA_49 2194864 tRNA -1 1469230 1469320 91 validated/Curated no Ser tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:55:37 no tRNA Ser anticodon TGA. vladimir NMV_1505 2192467 CDS -3 1469403 1470182 780 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 17:08:16 no 1 vladimir 0.283333 0.2474 0.225641 0.24359 0.473077 0.526923 0.280769 0.246154 0.296154 0.176923 0.542308 0.457692 0.369231 0.207692 0.123077 0.3 0.330769 0.669231 0.2 0.288462 0.257692 0.253846 0.546154 0.453846 0.603623 29689.75 -0.349035 0.227799 0.436293 0.212355 0.127413 0.53668 0.46332 0.243243 0.123552 0.119691 5.798424 9.482625 NMV_1506 2192468 CDS -3 1470345 1471532 1188 validated/Curated no putative aminotransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.6.1.- RXN-8925 2008-05-01 17:08:06 no 1 vladimir 0.23569 0.2551 0.251684 0.257576 0.506734 0.493266 0.219697 0.232323 0.338384 0.209596 0.570707 0.429293 0.30303 0.224747 0.179293 0.292929 0.40404 0.59596 0.184343 0.308081 0.237374 0.270202 0.545455 0.454545 0.679162 44127.8 -0.148101 0.263291 0.503797 0.237975 0.116456 0.58481 0.41519 0.232911 0.116456 0.116456 5.650917 9.248101 NMV_1507 2192469 CDS -2 1471609 1472061 453 validated/Curated no dut deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase; dUTP pyrophosphatase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.6.1.23 DUTP-PYROP-RXN PWY0-166 2018-01-24 15:08:26 no Catalyses the following reaction: dUTP + H(2)O <=> dUMP + diphosphate. It decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. 1 vladimir 0.211921 0.1943 0.315673 0.278146 0.509934 0.490066 0.218543 0.152318 0.410596 0.218543 0.562914 0.437086 0.258278 0.192053 0.211921 0.337748 0.403974 0.596026 0.15894 0.238411 0.324503 0.278146 0.562914 0.437086 0.632534 16302.105 0.128667 0.286667 0.506667 0.266667 0.1 0.62 0.38 0.233333 0.106667 0.126667 5.030235 9.446667 NMV_1508 2192470 CDS +2 1472207 1472635 429 validated/Curated partial truncated putative AzlC-like protein (N-terminal half of the protein) 5 : Unknown function u : unknown 5 : Inner membrane protein 2018-01-24 15:08:47 no Some proteins in this entry are encoded by a gene, which is a part of the azl operon involved in branched-chain amino acid transport. Overexpression of this gene results in resistance to a leucine analogue, 4-azaleucine. 1 vladimir 0.26294 0.2484 0.244306 0.244306 0.492754 0.507246 0.347826 0.236025 0.242236 0.173913 0.478261 0.521739 0.198758 0.267081 0.180124 0.354037 0.447205 0.552795 0.242236 0.242236 0.310559 0.204969 0.552795 0.447205 0.569109 17654.365 0.2875 0.31875 0.45 0.225 0.10625 0.63125 0.36875 0.16875 0.1125 0.05625 9.840172 8.69375 NMV_1509 2192471 CDS -1 1474310 1474798 489 validated/Curated no pilX pilL minor pilin PilX 1a : Function from experimental evidences in the studied strain s : structure 3 : Fimbrial 6.5 : Pilus ; 2020-04-25 14:22:37 no 15612917, 17893339 Minor pilus subunit that assembles within the filaments in a similar way to PilE, but is not required for pilus biogenesis. Surface-exposed motifs in PilX subunits stabilise bacterial aggregates against the disruptive force of pilus retraction. 1 vladimir 0.312883 0.1881 0.231084 0.267894 0.419223 0.580777 0.380368 0.122699 0.288344 0.208589 0.411043 0.588957 0.355828 0.190184 0.153374 0.300613 0.343558 0.656442 0.202454 0.251534 0.251534 0.294479 0.503067 0.496933 0.580087 18162.285 -0.231481 0.277778 0.481481 0.222222 0.104938 0.530864 0.469136 0.228395 0.141975 0.08642 9.355034 9.080247 NMV_1510 2192472 CDS -3 1474788 1475387 600 validated/Curated no pilK type IV pilus biogenesis protein PilK 1a : Function from experimental evidences in the studied strain f : factor 1 : Unknown 6.5 : Pilus ; 2020-04-25 14:27:02 no 15612916, 15853879 Is processed by PilD. Is required for pilus biogenesis. 1 vladimir 0.281667 0.1850 0.283333 0.25 0.468333 0.531667 0.33 0.125 0.375 0.17 0.5 0.5 0.35 0.21 0.165 0.275 0.375 0.625 0.165 0.22 0.31 0.305 0.53 0.47 0.568432 21970.94 -0.309045 0.296482 0.567839 0.226131 0.070352 0.502513 0.497487 0.241206 0.115578 0.125628 5.387627 9.954774 NMV_1511 2192473 CDS -1 1475366 1476331 966 validated/Curated no pilJ type IV pilus biogenesis protein PilJ 1a : Function from experimental evidences in the studied strain f : factor 1 : Unknown 6.5 : Pilus ; 2020-04-25 14:33:17 no 15612916, 15853879 Is processed by PilD. Is required for pilus biogenesis. 1 vladimir 0.297101 0.1843 0.247412 0.271222 0.431677 0.568323 0.347826 0.13354 0.34472 0.173913 0.478261 0.521739 0.332298 0.201863 0.189441 0.276398 0.391304 0.608696 0.21118 0.217391 0.208075 0.363354 0.425466 0.574534 0.541987 35234.55 -0.3 0.314642 0.538941 0.211838 0.080997 0.510903 0.489097 0.249221 0.133956 0.115265 8.708504 9.158879 NMV_1512 2192474 CDS -2 1476328 1476948 621 validated/Curated no pilI type IV pilus biogenesis protein PilI 1a : Function from experimental evidences in the studied strain ph : phenotype 1 : Unknown 6.5 : Pilus ; 2018-01-24 15:09:43 no 15612916, 15853879 Is cleaved by PilD. Stabilises pili against PilT-mediated retraction. 1 vladimir 0.283414 0.2061 0.26248 0.247987 0.468599 0.531401 0.328502 0.149758 0.333333 0.188406 0.483092 0.516908 0.328502 0.246377 0.140097 0.285024 0.386473 0.613527 0.193237 0.222222 0.31401 0.270531 0.536232 0.463768 0.527772 22347.425 -0.170874 0.320388 0.563107 0.228155 0.067961 0.519417 0.480583 0.213592 0.106796 0.106796 5.608406 9.237864 NMV_1513 2192475 CDS -3 1476981 1477646 666 validated/Curated no pilH type IV pilus biogenesis protein PilH 1a : Function from experimental evidences in the studied strain f : factor 1 : Unknown 6.5 : Pilus ; 2020-04-25 14:33:54 no 15612916, 15853879 Is processed by PilD. Is required for pilus biogenesis. 1 vladimir 0.261261 0.2327 0.253754 0.252252 0.486486 0.513514 0.315315 0.193694 0.333333 0.157658 0.527027 0.472973 0.315315 0.198198 0.198198 0.288288 0.396396 0.603604 0.153153 0.306306 0.22973 0.310811 0.536036 0.463964 0.548075 24695.15 -0.246606 0.289593 0.542986 0.217195 0.099548 0.524887 0.475113 0.239819 0.144796 0.095023 9.278236 9.764706 NMV_1514 2192476 CDS -1 1477955 1479361 1407 validated/Curated no dnaB replicative DNA helicase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.6.4.12 RXN0-4261 2018-01-23 11:45:54 no Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. 2 vladimir 0.243781 0.2836 0.2715 0.201137 0.555082 0.444918 0.236674 0.236674 0.377399 0.149254 0.614073 0.385927 0.315565 0.228145 0.166311 0.289979 0.394456 0.605544 0.179104 0.385927 0.270789 0.164179 0.656716 0.343284 0.65661 52088.255 -0.332906 0.271368 0.474359 0.224359 0.07265 0.532051 0.467949 0.284188 0.130342 0.153846 5.030556 9.737179 NMV_1515 2192477 CDS +2 1479524 1480111 588 validated/Curated no sodB superoxide dismutase [Fe] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 5.6.2 : Detoxification (xenobiotic metabolism) ; 1.15.1.1 SUPEROX-DISMUT-RXN DETOX1-PWY 2018-01-29 16:57:29 no Catalyses the following reaction: 2 superoxides + 2 H(+) <=> O(2) + H(2)O(2). 2 vladimir 0.261905 0.2993 0.234694 0.204082 0.534014 0.465986 0.255102 0.193878 0.321429 0.229592 0.515306 0.484694 0.341837 0.270408 0.163265 0.22449 0.433673 0.566327 0.188776 0.433673 0.219388 0.158163 0.653061 0.346939 0.819747 21874.68 -0.408718 0.323077 0.502564 0.164103 0.174359 0.548718 0.451282 0.225641 0.117949 0.107692 5.781654 9.148718 NMV_1516 2192478 CDS -2 1482163 1482672 510 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 17:05:59 no 1 vladimir 0.260784 0.1804 0.2 0.358824 0.380392 0.619608 0.317647 0.170588 0.205882 0.305882 0.376471 0.623529 0.229412 0.2 0.123529 0.447059 0.323529 0.676471 0.235294 0.170588 0.270588 0.323529 0.441176 0.558824 0.539057 19420.79 0.871006 0.242604 0.360947 0.360947 0.159763 0.674556 0.325444 0.142012 0.106509 0.035503 9.696938 7.964497 NMV_1517 2192479 CDS -2 1483003 1483335 333 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-23 16:44:34 no 1 vladimir 0.225225 0.2282 0.342342 0.204204 0.570571 0.429429 0.135135 0.189189 0.495495 0.18018 0.684685 0.315315 0.351351 0.189189 0.225225 0.234234 0.414414 0.585586 0.189189 0.306306 0.306306 0.198198 0.612613 0.387387 0.679411 12158.805 -0.368182 0.309091 0.527273 0.163636 0.127273 0.572727 0.427273 0.3 0.063636 0.236364 3.884254 10.909091 NMV_1519 2192481 CDS +3 1483626 1484462 837 validated/Curated no cysT cysU sulfate transport system permease protein CysT 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 1.8.2 : Sulfur metabolism ; 2018-01-24 15:13:25 no Is one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysW. 1 vladimir 0.150538 0.2425 0.34767 0.259259 0.590203 0.409797 0.222222 0.200717 0.37276 0.204301 0.573477 0.426523 0.139785 0.275986 0.172043 0.412186 0.448029 0.551971 0.089606 0.250896 0.498208 0.16129 0.749104 0.250896 0.641323 29762.415 0.905755 0.323741 0.517986 0.309353 0.111511 0.744604 0.255396 0.115108 0.061151 0.053957 8.773659 8.874101 NMV_1520 2192482 CDS +2 1484717 1485577 861 validated/Curated no cysW sulfate transport system permease protein CysW 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 1.8.2 : Sulfur metabolism ; 2018-01-24 15:13:41 no Is one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysT. 2 vladimir 0.196283 0.2985 0.269454 0.235772 0.567944 0.432056 0.236934 0.219512 0.348432 0.195122 0.567944 0.432056 0.188153 0.254355 0.149826 0.407665 0.404181 0.595819 0.163763 0.421603 0.310105 0.10453 0.731707 0.268293 0.662315 31038.675 0.773776 0.300699 0.486014 0.328671 0.104895 0.692308 0.307692 0.13986 0.076923 0.062937 8.86808 8.587413 NMV_1521 2192483 CDS +1 1485574 1486647 1074 validated/Curated no cysA sulfate/thiosulfate import ATP-binding protein CysA (sulfate-transporting ATPase) 2a : Function from experimental evidences in other organisms t : transporter 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 7.3.2.3 2020-04-21 13:32:31 no 2 vladimir 0.277467 0.2989 0.227188 0.196462 0.526071 0.473929 0.251397 0.24581 0.346369 0.156425 0.592179 0.407821 0.357542 0.195531 0.148045 0.298883 0.343575 0.656425 0.223464 0.455307 0.187151 0.134078 0.642458 0.357542 0.735028 40174.52 -0.231933 0.254902 0.434174 0.246499 0.131653 0.537815 0.462185 0.285714 0.165266 0.120448 6.860023 9.114846 NMV_1522 2192484 CDS -3 1486704 1488230 1527 validated/Curated no ilvA L-threonine dehydratase biosynthetic (threonine deaminase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.18 : Isoleucine/valine ; 4.3.1.19 THREDEHYD-RXN ILEUSYN-PWY 2020-04-21 15:57:07 no Catalyses the following reaction: L-threonine <=> 2-oxobutanoate + NH(3). 1 vladimir 0.229208 0.2390 0.297315 0.234447 0.536346 0.463654 0.243615 0.182711 0.412574 0.1611 0.595285 0.404715 0.302554 0.212181 0.18664 0.298625 0.398821 0.601179 0.141454 0.3222 0.292731 0.243615 0.614931 0.385069 0.640416 55210.655 -0.060236 0.297244 0.533465 0.240157 0.100394 0.586614 0.413386 0.253937 0.124016 0.129921 5.357826 9.645669 NMV_1523 2192485 CDS +3 1488378 1489547 1170 validated/Curated no dacC D-alanyl-D-alanine carboxypeptidase DacC (DD-peptidase; DD-carboxypeptidase; CPase; PBP5) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.6.7 : Peptidoglycan (murein) ; 3.4.16.4 3.4.16.4-RXN 2020-02-22 17:00:08 no Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 2 vladimir 0.325641 0.2778 0.211111 0.18547 0.488889 0.511111 0.34359 0.207692 0.3 0.148718 0.507692 0.492308 0.317949 0.266667 0.14359 0.271795 0.410256 0.589744 0.315385 0.358974 0.189744 0.135897 0.548718 0.451282 0.584785 42685.39 -0.296144 0.305913 0.493573 0.22108 0.079692 0.521851 0.478149 0.226221 0.143959 0.082262 9.81881 8.894602 NMV_1524 2192486 CDS -2 1489672 1490244 573 validated/Curated no rplY 50S ribosomal protein L25 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 15:14:26 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.256545 0.2635 0.228621 0.251309 0.492147 0.507853 0.21466 0.240838 0.397906 0.146597 0.638743 0.361257 0.319372 0.21466 0.146597 0.319372 0.361257 0.638743 0.235602 0.335079 0.141361 0.287958 0.47644 0.52356 0.850831 20955.205 -0.103158 0.257895 0.494737 0.278947 0.078947 0.536842 0.463158 0.278947 0.152632 0.126316 6.665947 9.389474 NMV_1525 2192487 CDS -2 1490311 1491273 963 validated/Curated no prs ribose-phosphate pyrophosphokinase (RPPK; phosphoribosyl pyrophosphate synthetase; P-Rib-PP synthetase; PRPP synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.41 : PRPP biosynthesis I ; 2.7.6.1 PRPPSYN-RXN PWY0-662 2018-01-24 15:14:58 no Catalyses the following reaction: ATP + D-ribose 5-phosphate <=> AMP + 5-phospho-alpha-D-ribose 1-diphosphate. 2 vladimir 0.23374 0.2663 0.262195 0.237805 0.528455 0.471545 0.268293 0.195122 0.390244 0.146341 0.585366 0.414634 0.268293 0.253049 0.155488 0.323171 0.408537 0.591463 0.164634 0.35061 0.240854 0.243902 0.591463 0.408537 0.726676 35596.49 0.094801 0.296636 0.556575 0.272171 0.055046 0.562691 0.437309 0.238532 0.116208 0.122324 5.412407 9.691131 NMV_tRNA_48 2194863 tRNA -1 1491461 1491536 76 validated/Curated no Gln tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:55:51 no tRNA Gln anticodon TTG. vladimir NMV_tRNA_47 2194862 tRNA -1 1491545 1491620 76 validated/Curated no Gln tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:56:02 no tRNA Gln anticodon TTG. vladimir NMV_tRNA_46 2194861 tRNA -1 1491633 1491708 76 validated/Curated no Gln tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:56:11 no tRNA Gln anticodon TTG. vladimir NMV_1526 2192488 CDS -1 1491716 1492561 846 validated/Curated no ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 2.7.1.148 2.7.1.148-RXN NONMEVIPP-PWY 2018-01-24 15:17:03 no Catalyses the following reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol <=> ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. 1 vladimir 0.262411 0.2187 0.271868 0.247045 0.490544 0.509456 0.248227 0.198582 0.336879 0.216312 0.535461 0.464539 0.308511 0.223404 0.184397 0.283688 0.407801 0.592199 0.230496 0.234043 0.294326 0.241135 0.528369 0.471631 0.575813 31386.6 -0.172242 0.284698 0.505338 0.220641 0.124555 0.580071 0.419929 0.231317 0.120996 0.11032 6.242332 9.274021 NMV_1527 2192489 CDS -1 1492571 1493152 582 validated/Curated no lolB outer-membrane lipoprotein LolB 2b : Function from indirect experimental evidences (e.g. phenotypes) m : membrane component 8 : Outer membrane-associated 1.6.10 : Lipoprotein ; 2018-01-30 16:58:05 no Part of an ATP-dependent transport system responsible for the translocation of lipoproteins targeted to the outer membrane from the inner membrane. 1 vladimir 0.262887 0.2491 0.293814 0.194158 0.542955 0.457045 0.273196 0.216495 0.340206 0.170103 0.556701 0.443299 0.298969 0.242268 0.221649 0.237113 0.463918 0.536082 0.216495 0.28866 0.319588 0.175258 0.608247 0.391753 0.598975 21227.06 -0.390674 0.326425 0.528497 0.207254 0.088083 0.53886 0.46114 0.212435 0.108808 0.103627 5.953514 9.968912 NMV_1529 2192491 CDS -3 1493292 1495136 1845 validated/Curated no conserved hypothetical TPR-containing periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-24 15:17:57 no Contains tetratrico peptide repeat (TPR) structural motifs, which mediate protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.261247 0.2336 0.313821 0.191328 0.547425 0.452575 0.234146 0.230894 0.38374 0.15122 0.614634 0.385366 0.336585 0.235772 0.169106 0.258537 0.404878 0.595122 0.213008 0.234146 0.388618 0.164228 0.622764 0.377236 0.525191 68646.955 -0.435342 0.275244 0.454397 0.213355 0.076547 0.540717 0.459283 0.286645 0.156352 0.130293 9.234764 9.736156 NMV_1530 2192492 CDS -1 1495301 1496137 837 validated/Curated no panC pantothenate synthetase (pantoate-beta-alanine ligase; pantoate activating enzyme) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.5 : Coenzyme A ; 1.5.3.23 : Pantothenate biosynthesis I ; 6.3.2.1 PANTOATE-BETA-ALANINE-LIG-RXN PANTO-PWY 2018-01-24 15:18:38 no Catalyses the following reaction: ATP + (R)-pantoate + beta-alanine <=> AMP + diphosphate + (R)-pantothenate. 1 vladimir 0.238949 0.2342 0.304659 0.222222 0.538829 0.461171 0.197133 0.236559 0.422939 0.143369 0.659498 0.340502 0.344086 0.189964 0.168459 0.297491 0.358423 0.641577 0.175627 0.275986 0.322581 0.225806 0.598566 0.401434 0.61419 31106.275 -0.26295 0.241007 0.492806 0.255396 0.089928 0.55036 0.44964 0.298561 0.147482 0.151079 5.585976 9.76259 NMV_1531 2192493 CDS -2 1496260 1497051 792 validated/Curated no panB 3-methyl-2-oxobutanoate hydroxymethyltransferase (ketopantoate hydroxymethyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.5 : Coenzyme A ; 1.5.3.23 : Pantothenate biosynthesis I ; 2.1.2.11 3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN PANTO-PWY 2018-01-24 15:19:51 no Catalyses the following reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate <=> tetrahydrofolate + 2-dehydropantoate. 1 vladimir 0.22601 0.2172 0.318182 0.238636 0.535354 0.464646 0.246212 0.17803 0.439394 0.136364 0.617424 0.382576 0.272727 0.253788 0.170455 0.30303 0.424242 0.575758 0.159091 0.219697 0.344697 0.276515 0.564394 0.435606 0.66416 27780.99 0.194677 0.365019 0.555133 0.201521 0.091255 0.627376 0.372624 0.209125 0.110266 0.098859 5.981392 9.65019 NMV_tRNA_45 2194860 tRNA -1 1497193 1497268 76 validated/Curated no Thr tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:56:26 no tRNA Thr anticodon TGT. vladimir NMV_tRNA_44 2194859 tRNA -1 1497303 1497378 76 validated/Curated no Thr tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:56:36 no tRNA Thr anticodon TGT. vladimir NMV_1532 2192494 CDS +1 1497544 1498335 792 validated/Curated no speE polyamine aminopropyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.14.3 : Spermidine biosynthesis ; 2.5.1.16 RXN-12514$SPERMIDINESYN-RXN BSUBPOLYAMSYN-PWY$PWY-6834 2018-01-24 15:21:45 no Catalyses the following reaction: S-adenosyl 3-(methylthio)propylamine + putrescine <=> 5'-S-methyl-5'-thioadenosine + spermidine. 2 vladimir 0.252525 0.3018 0.239899 0.205808 0.541667 0.458333 0.253788 0.246212 0.325758 0.174242 0.57197 0.42803 0.314394 0.185606 0.200758 0.299242 0.386364 0.613636 0.189394 0.473485 0.193182 0.143939 0.666667 0.333333 0.70701 29749.59 -0.311787 0.258555 0.463878 0.21673 0.13308 0.532319 0.467681 0.277567 0.144487 0.13308 5.864326 9.174905 NMV_1533 2192495 CDS +1 1498390 1499031 642 validated/Curated no putative hydrolase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-24 15:22:11 no Belongs to the alpha/beta superfamily of hydrolases. 2 vladimir 0.238318 0.3520 0.221184 0.188474 0.573209 0.426791 0.224299 0.257009 0.373832 0.14486 0.630841 0.369159 0.271028 0.275701 0.168224 0.285047 0.443925 0.556075 0.219626 0.523364 0.121495 0.135514 0.64486 0.35514 0.673588 22727.19 0.071831 0.328638 0.539906 0.239437 0.112676 0.619718 0.380282 0.215962 0.122066 0.093897 6.197151 9.361502 NMV_1534 2192496 CDS -3 1499109 1500032 924 validated/Curated no putative RNA pseudouridine synthase (RNA-uridine isomerase; RNA pseudouridylate synthase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.4.99.- 2018-01-23 12:39:50 no Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in 23S rRNA. 1 vladimir 0.227273 0.2240 0.294372 0.254329 0.518398 0.481602 0.243506 0.275974 0.295455 0.185065 0.571429 0.428571 0.308442 0.201299 0.178571 0.311688 0.37987 0.62013 0.12987 0.194805 0.409091 0.266234 0.603896 0.396104 0.562394 35224.48 -0.329967 0.221498 0.442997 0.234528 0.136808 0.550489 0.449511 0.296417 0.172638 0.123779 8.363503 9.514658 NMV_1535 2192497 CDS +2 1500197 1501066 870 validated/Curated no conserved hypothetical outer-membrane protein 4 : Unknown function but conserved in other organisms u : unknown 8 : Outer membrane-associated 2008-05-01 15:52:33 no 2 vladimir 0.283908 0.3253 0.203448 0.187356 0.528736 0.471264 0.348276 0.193103 0.275862 0.182759 0.468966 0.531034 0.293103 0.268966 0.189655 0.248276 0.458621 0.541379 0.210345 0.513793 0.144828 0.131034 0.658621 0.341379 0.660792 31495.4 -0.318685 0.366782 0.529412 0.200692 0.103806 0.508651 0.491349 0.214533 0.128028 0.086505 9.44529 8.446367 NMV_1536 2192498 CDS +2 1501109 1501504 396 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:52:15 no 1 vladimir 0.267677 0.2045 0.313131 0.214646 0.517677 0.482323 0.272727 0.159091 0.424242 0.143939 0.583333 0.416667 0.227273 0.280303 0.212121 0.280303 0.492424 0.507576 0.30303 0.174242 0.30303 0.219697 0.477273 0.522727 0.513275 13507.88 0.103817 0.419847 0.580153 0.152672 0.091603 0.656489 0.343511 0.122137 0.068702 0.053435 8.308174 9.801527 NMV_1537 2192499 CDS +3 1501494 1501709 216 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:52:03 no 1 vladimir 0.337963 0.2130 0.152778 0.296296 0.365741 0.634259 0.402778 0.125 0.25 0.222222 0.375 0.625 0.25 0.263889 0.083333 0.402778 0.347222 0.652778 0.361111 0.25 0.125 0.263889 0.375 0.625 0.470759 8005.16 0.64507 0.323944 0.43662 0.253521 0.15493 0.605634 0.394366 0.140845 0.070423 0.070423 5.626457 8.450704 NMV_1539 2192501 CDS +1 1501912 1502199 288 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:51:51 no 3 vladimir 0.336806 0.1007 0.166667 0.395833 0.267361 0.732639 0.364583 0.041667 0.25 0.34375 0.291667 0.708333 0.270833 0.135417 0.135417 0.458333 0.270833 0.729167 0.375 0.125 0.114583 0.385417 0.239583 0.760417 0.48437 10874.52 0.808421 0.252632 0.368421 0.315789 0.178947 0.642105 0.357895 0.2 0.094737 0.105263 5.216728 7.557895 NMV_1541 2192503 CDS +2 1502468 1502692 225 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-19 18:22:41 no 1 vladimir 0.337838 0.1937 0.153153 0.315315 0.346847 0.653153 0.378378 0.108108 0.27027 0.243243 0.378378 0.621622 0.27027 0.243243 0.067568 0.418919 0.310811 0.689189 0.364865 0.22973 0.121622 0.283784 0.351351 0.648649 0.512077 8288.56 0.710959 0.287671 0.39726 0.260274 0.164384 0.643836 0.356164 0.164384 0.082192 0.082192 5.646965 8.383562 NMV_1542 2192504 CDS +2 1502780 1503253 474 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:51:24 no 3 vladimir 0.28481 0.1899 0.278481 0.246835 0.468354 0.531646 0.35443 0.126582 0.373418 0.14557 0.5 0.5 0.234177 0.316456 0.202532 0.246835 0.518987 0.481013 0.265823 0.126582 0.259494 0.348101 0.386076 0.613924 0.540034 16245.97 0.010191 0.44586 0.55414 0.152866 0.076433 0.598726 0.401274 0.165605 0.11465 0.050955 10.068642 9.210191 NMV_1543 2192505 CDS +1 1503259 1503549 291 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:51:11 no 3 vladimir 0.281787 0.1168 0.223368 0.378007 0.340206 0.659794 0.340206 0.103093 0.268041 0.28866 0.371134 0.628866 0.268041 0.113402 0.175258 0.443299 0.28866 0.71134 0.237113 0.134021 0.226804 0.402062 0.360825 0.639175 0.40624 11001.795 0.880208 0.239583 0.40625 0.333333 0.166667 0.697917 0.302083 0.166667 0.09375 0.072917 8.406227 8.333333 NMV_1544 2192506 CDS +3 1503576 1503746 171 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:51:00 no 3 vladimir 0.269006 0.1462 0.298246 0.28655 0.444444 0.555556 0.350877 0.087719 0.385965 0.175439 0.473684 0.526316 0.175439 0.157895 0.385965 0.280702 0.54386 0.45614 0.280702 0.192982 0.122807 0.403509 0.315789 0.684211 0.470313 5689.315 0.225 0.464286 0.625 0.232143 0.053571 0.642857 0.357143 0.160714 0.125 0.035714 9.888771 10.107143 NMNmiscRNA0079 52720921 misc_RNA -1 1503749 1503844 96 validated/Curated no ncRNA 1b : Function from experimental evidences in the studied species 2018-01-28 20:18:34 25951061, 28334889 Originally found in strain MC58. vladimir NMV_1546 2192508 CDS +2 1504250 1504795 546 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:50:48 no 3 vladimir 0.278388 0.2033 0.261905 0.25641 0.465201 0.534799 0.324176 0.186813 0.340659 0.148352 0.527473 0.472527 0.263736 0.269231 0.214286 0.252747 0.483516 0.516484 0.247253 0.153846 0.230769 0.368132 0.384615 0.615385 0.547669 19720.9 -0.352486 0.342541 0.513812 0.154696 0.110497 0.574586 0.425414 0.232044 0.165746 0.066298 10.495033 9.79558 NMV_1547 2192509 CDS +1 1504777 1505142 366 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:50:33 no 3 vladimir 0.306011 0.1393 0.215847 0.338798 0.355191 0.644809 0.254098 0.172131 0.295082 0.278689 0.467213 0.532787 0.352459 0.180328 0.122951 0.344262 0.303279 0.696721 0.311475 0.065574 0.229508 0.393443 0.295082 0.704918 0.530492 13966.61 -0.180992 0.22314 0.429752 0.22314 0.123967 0.520661 0.479339 0.289256 0.123967 0.165289 4.736931 8.338843 NMV_1548 2192510 CDS +1 1505200 1505619 420 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:50:21 no 3 vladimir 0.342857 0.1143 0.2 0.342857 0.314286 0.685714 0.364286 0.092857 0.228571 0.314286 0.321429 0.678571 0.342857 0.15 0.185714 0.321429 0.335714 0.664286 0.321429 0.1 0.185714 0.392857 0.285714 0.714286 0.465656 16380.36 -0.270504 0.244604 0.381295 0.223022 0.158273 0.517986 0.482014 0.266187 0.158273 0.107914 9.153053 9.280576 NMV_1549 2192511 CDS +1 1505776 1505934 159 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2015-11-19 18:22:04 no 1 vladimir 0.303483 0.1493 0.273632 0.273632 0.422886 0.577114 0.298507 0.119403 0.313433 0.268657 0.432836 0.567164 0.328358 0.208955 0.208955 0.253731 0.41791 0.58209 0.283582 0.119403 0.298507 0.298507 0.41791 0.58209 0.485511 7794.525 -0.506061 0.287879 0.439394 0.151515 0.151515 0.515152 0.484848 0.257576 0.136364 0.121212 6.779915 11 NMV_1550 2192512 CDS +1 1505938 1506114 177 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:50:00 no 3 vladimir 0.367232 0.1356 0.237288 0.259887 0.372881 0.627119 0.40678 0.152542 0.271186 0.169492 0.423729 0.576271 0.372881 0.135593 0.254237 0.237288 0.389831 0.610169 0.322034 0.118644 0.186441 0.372881 0.305085 0.694915 0.476795 6853.435 -0.837931 0.258621 0.396552 0.172414 0.189655 0.448276 0.551724 0.327586 0.206897 0.12069 8.407722 9.672414 NMV_1551 2192513 CDS +3 1506171 1506638 468 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:49:49 no 3 vladimir 0.333333 0.1154 0.147436 0.403846 0.262821 0.737179 0.320513 0.121795 0.224359 0.333333 0.346154 0.653846 0.410256 0.147436 0.102564 0.339744 0.25 0.75 0.269231 0.076923 0.115385 0.538462 0.192308 0.807692 0.543916 18474.54 -0.184516 0.174194 0.419355 0.212903 0.206452 0.56129 0.43871 0.245161 0.116129 0.129032 5.13192 8.593548 NMV_1552 2192514 CDS +2 1506671 1506862 192 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:49:38 no 3 vladimir 0.28125 0.1406 0.260417 0.317708 0.401042 0.598958 0.28125 0.078125 0.328125 0.3125 0.40625 0.59375 0.3125 0.21875 0.203125 0.265625 0.421875 0.578125 0.25 0.125 0.25 0.375 0.375 0.625 0.553198 7124.82 -0.031746 0.333333 0.460317 0.222222 0.15873 0.571429 0.428571 0.238095 0.111111 0.126984 5.159477 8.730159 NMV_1553 2192515 CDS +2 1506923 1507576 654 validated/Curated no putative peptidase 3 : Putative function from multiple computational evidences e : enzyme 6 : Inner membrane-associated 2018-01-24 15:25:10 no Belongs to the MEROPS peptidase family C39 (clan CA), which are involved in the proteolytic maturation of bacteriocins. 1 vladimir 0.254186 0.1872 0.283105 0.275495 0.47032 0.52968 0.255708 0.187215 0.328767 0.22831 0.515982 0.484018 0.342466 0.205479 0.13242 0.319635 0.3379 0.6621 0.164384 0.16895 0.388128 0.278539 0.557078 0.442922 0.570525 24944.935 -0.21789 0.238532 0.440367 0.224771 0.123853 0.541284 0.458716 0.275229 0.16055 0.114679 9.244377 9.238532 NMV_1554 2192516 CDS +2 1507703 1508998 1296 validated/Curated no hisS histidine-tRNA ligase (histidyl-tRNA synthetase; HisRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.21 HISTIDINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:51:38 no Catalyses the attachment of histidine to its cognate transfer RNA molecule in a highly specific two-step reaction. 1 vladimir 0.251543 0.2400 0.280864 0.227623 0.520833 0.479167 0.233796 0.224537 0.358796 0.18287 0.583333 0.416667 0.351852 0.201389 0.185185 0.261574 0.386574 0.613426 0.168981 0.293981 0.298611 0.238426 0.592593 0.407407 0.720567 48591.11 -0.461253 0.276102 0.464037 0.201856 0.106729 0.531323 0.468677 0.264501 0.132251 0.132251 5.645363 9.916473 NMV_1555 2192517 CDS +2 1508999 1509628 630 validated/Curated no conserved hypothetical TPR-containing membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2020-04-23 18:53:00 no Belongs to the UPF0070 family of proteins, which are not functionally characterised. Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.287302 0.2571 0.257143 0.198413 0.514286 0.485714 0.214286 0.228571 0.385714 0.171429 0.614286 0.385714 0.390476 0.257143 0.095238 0.257143 0.352381 0.647619 0.257143 0.285714 0.290476 0.166667 0.576191 0.42381 0.708497 23032.26 -0.242105 0.296651 0.464115 0.210526 0.095694 0.555024 0.444976 0.22488 0.110048 0.114833 5.444771 9.047847 NMV_1556 2192518 CDS +2 1509629 1511239 1611 validated/Curated no der GTPase Der (EngA) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; RXN0-5462 2018-01-30 15:09:33 no GTPase that plays an essential role in the late steps of ribosome biogenesis. 2 vladimir 0.262003 0.2737 0.266118 0.198217 0.53978 0.460219 0.265432 0.22428 0.384774 0.125514 0.609054 0.390946 0.331276 0.211934 0.176955 0.279835 0.388889 0.611111 0.1893 0.384774 0.236626 0.1893 0.621399 0.378601 0.754526 53975.69 -0.39299 0.259794 0.496907 0.22268 0.094845 0.534021 0.465979 0.303093 0.175258 0.127835 9.435036 9.523711 NMV_1557 2192519 CDS +2 1511270 1512169 900 validated/Curated no rdgC recombination associated protein RdgC 1c : Function from experimental evidences in the studied genus ph : phenotype 2 : Cytoplasmic 2018-01-24 15:26:23 no 10655208 Members of the RdgC family may have exonuclease activity. RdgC is required for efficient pilin variation in N. gonorrhoeae, suggesting that it may be involved in recombination reactions. 2 vladimir 0.266667 0.2744 0.245556 0.213333 0.52 0.48 0.236667 0.22 0.376667 0.166667 0.596667 0.403333 0.34 0.213333 0.153333 0.293333 0.366667 0.633333 0.223333 0.39 0.206667 0.18 0.596667 0.403333 0.709834 33276.46 -0.250836 0.277592 0.474916 0.234114 0.090301 0.518395 0.481605 0.274247 0.117057 0.157191 4.782112 9 NMV_1557.1 2662687 fCDS +3 1512231 1512377 147 validated/Curated pseudo hypothetical periplasmic protein (pseudogene part 1) 5 : Unknown function u : unknown 9 : Periplasmic 2008-06-18 16:27:53 vladimir NMV_1558 2192520 fCDS +2 1512377 1512646 270 validated/Curated pseudo hypothetical periplasmic protein (pseudogene part 2) 5 : Unknown function u : unknown 9 : Periplasmic 2008-06-18 16:28:07 no 2 vladimir 0.333333 0.2527 0.208791 0.205128 0.461538 0.538462 0.373626 0.142857 0.285714 0.197802 0.428571 0.571429 0.362637 0.164835 0.197802 0.274725 0.362637 0.637363 0.263736 0.450549 0.142857 0.142857 0.593407 0.406593 0.710885 10161.225 -0.606667 0.288889 0.488889 0.144444 0.122222 0.488889 0.511111 0.266667 0.177778 0.088889 9.744362 9.6 NMV_1559 2192521 CDS +1 1512712 1513278 567 validated/Curated no dcd dCTP deaminase (deoxycytidine triphosphate deaminase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 3.5.4.13 DCTP-DEAM-RXN PWY0-166 2018-01-24 15:27:17 no Catalyses the following reaction: dCTP + H(2)O <=> dUTP + NH(3). 2 vladimir 0.276896 0.3298 0.209877 0.183422 0.539683 0.460317 0.333333 0.15873 0.306878 0.201058 0.465608 0.534392 0.31746 0.222222 0.185185 0.275132 0.407407 0.592593 0.179894 0.608466 0.137566 0.074074 0.746032 0.253968 0.816209 21294.475 -0.291489 0.281915 0.521277 0.191489 0.12234 0.542553 0.457447 0.244681 0.111702 0.132979 5.043053 9.819149 NMV_1560 2192522 CDS -2 1513342 1514046 705 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-01 15:47:52 no 1 vladimir 0.243972 0.2099 0.302128 0.243972 0.512057 0.487943 0.26383 0.13617 0.421277 0.178723 0.557447 0.442553 0.297872 0.246809 0.182979 0.27234 0.429787 0.570213 0.170213 0.246809 0.302128 0.280851 0.548936 0.451064 0.640822 25517.805 -0.241453 0.333333 0.534188 0.188034 0.094017 0.534188 0.465812 0.260684 0.141026 0.119658 8.78936 9.692308 NMV_1561 2192523 fCDS +1 1514215 1514376 162 validated/Curated pseudo putative glycosyl transferase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-06-18 16:28:29 no 1 vladimir 0.2397 0.2509 0.258427 0.250936 0.509363 0.490637 0.280899 0.191011 0.292135 0.235955 0.483146 0.516854 0.168539 0.337079 0.213483 0.280899 0.550562 0.449438 0.269663 0.224719 0.269663 0.235955 0.494382 0.505618 0.529849 9468.675 0.167045 0.431818 0.556818 0.204545 0.090909 0.568182 0.431818 0.159091 0.136364 0.022727 10.97184 9.147727 NMV_1562 2192524 fCDS +3 1514376 1514762 387 validated/Curated pseudo putative glycosyl transferase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-06-18 16:28:42 no 1 vladimir 0.253119 0.3102 0.229947 0.206774 0.540107 0.459893 0.245989 0.299465 0.26738 0.187166 0.566845 0.433155 0.320856 0.213904 0.224599 0.240642 0.438503 0.561497 0.192513 0.417112 0.197861 0.192513 0.614973 0.385027 0.651138 21526.875 -0.437097 0.274194 0.430108 0.177419 0.198925 0.564516 0.435484 0.263441 0.193548 0.069892 9.632637 9.790323 NMV_1563 2192525 fCDS +1 1514830 1515351 522 validated/Curated pseudo putative glycosyl transferase (pseudogene part 3) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-06-18 16:28:56 no 2 vladimir 0.261084 0.2627 0.262726 0.213465 0.525452 0.474548 0.236453 0.226601 0.369458 0.167488 0.596059 0.403941 0.29064 0.197044 0.221675 0.29064 0.418719 0.581281 0.256158 0.364532 0.197044 0.182266 0.561576 0.438424 0.535986 22385.805 -0.157921 0.30198 0.480198 0.242574 0.094059 0.554455 0.445545 0.272277 0.158416 0.113861 8.948509 9.722772 NMV_1564 2192526 CDS +1 1515577 1516530 954 validated/Curated no putative PhoH-like protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-24 15:28:37 no Homologous to PhoH, a predicted cytoplasmic ATPase belonging to the phosphate regulon in E. coli, which is induced by phosphate starvation. 2 vladimir 0.267296 0.3134 0.236897 0.18239 0.550314 0.449686 0.254717 0.264151 0.367925 0.113208 0.632075 0.367925 0.345912 0.204403 0.163522 0.286164 0.367925 0.632075 0.201258 0.471698 0.179245 0.147799 0.650943 0.349057 0.646262 35408.98 -0.312303 0.271293 0.460568 0.227129 0.123028 0.539432 0.460568 0.302839 0.167192 0.135647 6.324043 9.542587 NMV_1565 2192527 CDS -1 1516634 1516957 324 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-01 15:46:41 no 2 vladimir 0.259259 0.2222 0.283951 0.234568 0.506173 0.493827 0.287037 0.148148 0.361111 0.203704 0.509259 0.490741 0.277778 0.222222 0.231481 0.268519 0.453704 0.546296 0.212963 0.296296 0.259259 0.231481 0.555556 0.444444 0.653949 11883.21 -0.178505 0.345794 0.523364 0.17757 0.074766 0.523364 0.476636 0.280374 0.149533 0.130841 7.766533 10.261682 NMV_1566 2192528 CDS -3 1517130 1518491 1362 validated/Curated no pcnB poly(A) polymerase I (PAP; plasmid copy number protein) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.7.7.19 POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN 2018-01-24 15:29:20 no Sequentially adds adenosine nucleotides to the 3' end of RNAs, targeting them for degradation. 1 vladimir 0.251836 0.2599 0.288546 0.199706 0.548458 0.451542 0.264317 0.242291 0.356828 0.136564 0.599119 0.400881 0.30837 0.218062 0.204846 0.268722 0.422907 0.577093 0.182819 0.319383 0.303965 0.193833 0.623348 0.376652 0.636114 51664.45 -0.501325 0.264901 0.443709 0.19426 0.101545 0.516556 0.483444 0.328918 0.196468 0.13245 9.761772 9.953642 NMV_1567 2192529 CDS -1 1518923 1520695 1773 validated/Curated no recJ single-stranded-DNA-specific exonuclease RecJ 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.-.- RXN0-2622 2018-01-22 20:35:11 no Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. 2 vladimir 0.206937 0.2810 0.290417 0.221634 0.571429 0.428571 0.206349 0.236332 0.393298 0.164021 0.62963 0.37037 0.291005 0.227513 0.188713 0.292769 0.416226 0.583774 0.123457 0.379189 0.289242 0.208113 0.66843 0.33157 0.687668 62217.505 -0.120848 0.289753 0.517668 0.233216 0.091873 0.575972 0.424028 0.259717 0.127208 0.132509 5.371605 9.729682 NMV_1568 2192530 CDS -2 1520692 1521405 714 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:46:01 no 1 vladimir 0.261905 0.2675 0.254902 0.215686 0.522409 0.477591 0.294118 0.176471 0.344538 0.184874 0.521008 0.478992 0.336134 0.273109 0.117647 0.273109 0.390756 0.609244 0.155462 0.352941 0.302521 0.189076 0.655462 0.344538 0.680794 26269.18 -0.184388 0.303797 0.527426 0.194093 0.109705 0.561181 0.438819 0.236287 0.126582 0.109705 7.808723 9.274262 NMV_1569 2192531 CDS -1 1521452 1521964 513 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-19 18:17:36 no 2 vladimir 0.295139 0.2396 0.282986 0.182292 0.522569 0.477431 0.307292 0.21875 0.333333 0.140625 0.552083 0.447917 0.375 0.197917 0.15625 0.270833 0.354167 0.645833 0.203125 0.302083 0.359375 0.135417 0.661458 0.338542 0.624921 21541.88 -0.630366 0.256545 0.434555 0.188482 0.068063 0.481675 0.518325 0.314136 0.172775 0.141361 9.120049 9.319372 NMV_1570 2192532 CDS +2 1522118 1523449 1332 validated/Curated no putative PmbA-like metalloprotease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.4.-.- 2018-01-24 15:31:12 no Belongs to MEROPS peptidase family U62 (clan U-). PmbA is involved in CcdA degradation. 2 vladimir 0.222222 0.3311 0.275526 0.171171 0.606607 0.393393 0.22973 0.22973 0.396396 0.144144 0.626126 0.373874 0.295045 0.234234 0.227477 0.243243 0.461712 0.538288 0.141892 0.529279 0.202703 0.126126 0.731982 0.268018 0.704932 47877.44 -0.287133 0.365688 0.541761 0.194131 0.108352 0.537246 0.462754 0.250564 0.121896 0.128668 5.247597 9.683973 NMV_1572 2192534 CDS -1 1523747 1523950 204 validated/Curated no putative cold shock protein CspA 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-24 15:32:38 no Contains a domain of about 70 amino acids, known as the 'cold-shock domain' (CSD) because it is found in E. coli 'cold shock' proteins, which are thought to help the cell to survive in temperatures lower than optimum growth temperature. 2 vladimir 0.289216 0.2500 0.230392 0.230392 0.480392 0.519608 0.294118 0.117647 0.411765 0.176471 0.529412 0.470588 0.323529 0.25 0.161765 0.264706 0.411765 0.588235 0.25 0.382353 0.117647 0.25 0.5 0.5 0.865522 7194.8 -0.252239 0.358209 0.537313 0.134328 0.134328 0.567164 0.432836 0.238806 0.119403 0.119403 5.66021 8.880597 NMNmisc_RNA1523683R 19685073 misc_RNA -1 1523950 1524065 116 validated/Curated no CspA thermoregulator 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 18:34:52 28334889 Acts as an RNA thermometer, regulating the expression of the neighbouring cspA in response to temperature. vladimir NMV_1573 2192535 CDS +1 1524157 1524495 339 validated/Curated no clpS ATP-dependent Clp protease adapter protein ClpS 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-01-24 15:33:14 no ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins. 2 vladimir 0.283828 0.2772 0.237624 0.20132 0.514851 0.485149 0.247525 0.306931 0.316832 0.128713 0.623762 0.376238 0.366337 0.188119 0.118812 0.326733 0.306931 0.693069 0.237624 0.336634 0.277228 0.148515 0.613861 0.386139 0.682205 11410.755 -0.164 0.24 0.41 0.25 0.11 0.53 0.47 0.25 0.13 0.12 5.642693 10.05 NMV_1574 2192536 CDS +2 1524497 1526794 2298 validated/Curated no clpA ATP-dependent Clp protease ATP-binding subunit ClpA 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.4.21.92-RXN 2018-01-24 15:33:38 no ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. 2 vladimir 0.259356 0.3085 0.248042 0.184073 0.556571 0.443429 0.244125 0.245431 0.374674 0.13577 0.620104 0.379896 0.330287 0.221932 0.144909 0.302872 0.366841 0.633159 0.203655 0.458225 0.224543 0.113577 0.682768 0.317232 0.700678 84471.91 -0.211242 0.266667 0.475817 0.24183 0.08366 0.543791 0.456209 0.291503 0.152941 0.138562 6.23304 9.105882 NMV_1575 2192537 CDS -1 1526858 1527862 1005 validated/Curated no rfaD hldD ADP-L-glycero-D-manno-heptose-6-epimerase (ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME) 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3.2 : Core region ; 5.1.3.20 5.1.3.20-RXN PWY0-1241 2018-01-24 15:34:15 no 12618369, 7730260 Catalyses the following reaction: ADP-D-glycero-D-manno-heptose <=> ADP-L-glycero-D-manno-heptose. Is involved in biosynthesis of the inner core of lipooligosaccharide. 2 vladimir 0.280597 0.2955 0.219901 0.20398 0.515423 0.484577 0.244776 0.208955 0.358209 0.18806 0.567164 0.432836 0.397015 0.146269 0.173134 0.283582 0.319403 0.680597 0.2 0.531343 0.128358 0.140299 0.659701 0.340299 0.76765 38478.935 -0.441916 0.239521 0.434132 0.197605 0.164671 0.532934 0.467066 0.287425 0.146707 0.140719 5.684029 10.023952 NMV_1576 2192538 CDS -3 1527903 1529021 1119 validated/Curated no putative type II restriction-modification system enzyme Res 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-01 15:44:26 no 3 vladimir 0.352994 0.1278 0.190349 0.328865 0.318141 0.681859 0.335121 0.16622 0.246649 0.252011 0.412869 0.587131 0.420912 0.126005 0.158177 0.294906 0.284182 0.715818 0.302949 0.091153 0.16622 0.439678 0.257373 0.742627 0.504131 44742.345 -0.634409 0.163978 0.376344 0.223118 0.166667 0.481183 0.518817 0.319892 0.174731 0.145161 7.766747 9.400538 NMV_1577 2192539 CDS -2 1529023 1530258 1236 validated/Curated no putative type II restriction-modification system enzyme Mod 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.37 DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-24 15:34:55 no Is a C-5 cytosine-specific DNA methylase, an enzyme that specifically methylates the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. 3 vladimir 0.337379 0.1456 0.190939 0.326052 0.33657 0.66343 0.317961 0.177184 0.291262 0.213592 0.468447 0.531553 0.378641 0.15534 0.162621 0.303398 0.317961 0.682039 0.315534 0.104369 0.118932 0.461165 0.223301 0.776699 0.540641 47796.68 -0.454745 0.223844 0.440389 0.206813 0.158151 0.501217 0.498783 0.279805 0.163017 0.116788 8.912727 9.357664 NMV_1578 2192540 CDS -2 1530295 1531266 972 validated/Curated no rfaE1 D-beta-D-heptose 7-phosphate kinase (D-beta-D-heptose 7-phosphotransferase) 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.7.1.167 RXN0-4341 PWY0-1241 2018-01-22 20:19:24 no 12618369, 8755886 Unlike in E. coli, the two domains of RfaE are genetically separated in N. meningitidis. This entry corresponds to the N-terminal domain I suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis. 1 vladimir 0.244856 0.2912 0.27572 0.188272 0.566872 0.433128 0.234568 0.194444 0.416667 0.154321 0.611111 0.388889 0.302469 0.243827 0.169753 0.283951 0.41358 0.58642 0.197531 0.435185 0.240741 0.126543 0.675926 0.324074 0.699852 34996.56 -0.105263 0.321981 0.526316 0.232198 0.074303 0.569659 0.430341 0.250774 0.120743 0.130031 5.310188 9.535604 NMV_1579 2192541 CDS -2 1531321 1532061 741 validated/Curated no pyrF orotidine 5'-phosphate decarboxylase (OMP decarboxylase; OMPDCase; OMPdecase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; 4.1.1.23 OROTPDECARB-RXN PWY-5686 2018-01-24 15:35:31 no Catalydes the last step in the de novo biosynthesis of pyrimidines: orotidine 5'-phosphate <=> UMP + CO(2). 2 vladimir 0.240216 0.2942 0.259109 0.206478 0.553306 0.446694 0.238866 0.218623 0.396761 0.145749 0.615385 0.384615 0.271255 0.246964 0.165992 0.315789 0.412955 0.587045 0.210526 0.417004 0.214575 0.157895 0.631579 0.368421 0.689908 26509.445 0.067073 0.304878 0.54065 0.252033 0.056911 0.589431 0.410569 0.215447 0.101626 0.113821 5.148903 9.747967 NMV_1580 2192542 CDS -1 1532588 1533235 648 validated/Curated no adk adenylate kinase (ATP-AMP transphosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.7.4.3 ADENYL-KIN-RXN P1-PWY$PWY-6126 2018-01-24 15:36:49 no Catalyses the following reaction: ATP + AMP <=> 2 ADP. 2 vladimir 0.265432 0.2608 0.282407 0.191358 0.54321 0.45679 0.240741 0.171296 0.467593 0.12037 0.638889 0.361111 0.337963 0.203704 0.166667 0.291667 0.37037 0.62963 0.217593 0.407407 0.212963 0.162037 0.62037 0.37963 0.814087 23215.56 -0.196744 0.283721 0.525581 0.24186 0.069767 0.567442 0.432558 0.311628 0.144186 0.167442 5.01667 9.381395 NMV_1581 2192543 CDS +3 1533450 1534289 840 validated/Curated no putative HtpX-like protease 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 3.4.24.- 2018-01-23 11:39:09 no Belongs to MEROPS peptidase family M48 (Ste24 endopeptidase family, clan M-). Is similar to the heat shock protein HtpX, which might play a role in the response to misfolded proteins. 2 vladimir 0.22381 0.3012 0.259524 0.215476 0.560714 0.439286 0.282143 0.207143 0.353571 0.157143 0.560714 0.439286 0.228571 0.242857 0.171429 0.357143 0.414286 0.585714 0.160714 0.453571 0.253571 0.132143 0.707143 0.292857 0.669101 30168.7 0.329032 0.318996 0.530466 0.283154 0.086022 0.591398 0.408602 0.182796 0.100358 0.082437 7.16935 8.946237 NMV_1582 2192544 CDS -2 1534525 1535823 1299 validated/Curated no purA adenylosuccinate synthetase (IMP-aspartate ligase; AdSS; AMPSase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.4.4 ADENYLOSUCCINATE-SYNTHASE-RXN PWY-6126 2020-04-21 15:58:40 no Plays an important role in purine biosynthesis, by catalysing the following reaction: GTP + IMP + L-aspartate <=> GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. 1 vladimir 0.229407 0.2833 0.287914 0.199384 0.571209 0.428791 0.221709 0.189376 0.43649 0.152425 0.625866 0.374134 0.284065 0.233256 0.203233 0.279446 0.43649 0.56351 0.182448 0.427252 0.224018 0.166282 0.65127 0.34873 0.81004 46017.865 -0.030093 0.328704 0.548611 0.240741 0.083333 0.613426 0.386574 0.25463 0.12963 0.125 5.774391 9.650463 NMV_1583 2192545 CDS -1 1535927 1537078 1152 validated/Curated no hisZ ATP phosphoribosyltransferase regulatory subunit 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; ATPPHOSPHORIBOSYLTRANS-RXN HISTSYN-PWY 2018-01-24 15:37:49 no Is required for the first step of histidine biosynthesis. 1 vladimir 0.195312 0.2639 0.329861 0.210938 0.59375 0.40625 0.169271 0.25 0.411458 0.169271 0.661458 0.338542 0.286458 0.221354 0.195312 0.296875 0.416667 0.583333 0.130208 0.320312 0.382812 0.166667 0.703125 0.296875 0.601785 41744.09 -0.023238 0.302872 0.490862 0.248042 0.099217 0.605744 0.394256 0.261097 0.130548 0.130548 5.455025 9.509138 NMV_1584 2192546 CDS +3 1537413 1538792 1380 validated/Curated no putative multidrug resistance protein NorM (multidrug-efflux transporter) 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-24 15:38:09 no Belongs to the the Multi AnTimicrobial Extrusion (MATE) family of proteins that function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibiotics and drugs. 1 vladimir 0.161594 0.2601 0.310145 0.268116 0.57029 0.42971 0.228261 0.178261 0.347826 0.245652 0.526087 0.473913 0.163043 0.247826 0.195652 0.393478 0.443478 0.556522 0.093478 0.354348 0.386957 0.165217 0.741304 0.258696 0.664849 49951.27 0.803922 0.342048 0.501089 0.270153 0.152505 0.727669 0.272331 0.119826 0.074074 0.045752 9.271721 8.862745 NMV_1585 2192547 CDS +1 1538971 1540011 1041 validated/Curated no murB UDP-N-acetylenolpyruvoylglucosamine reductase (UDP-N-acetylmuramate dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.7 : Peptidoglycan (murein) ; 1.3.1.98 UDPNACETYLMURAMATEDEHYDROG-RXN PEPTIDOGLYCANSYN-PWY$PWY-6385$PWY-6387 2018-01-19 10:22:26 no Catalyses the following reaction: UDP-N-acetylmuramate + NADP(+) <=> UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide, which is a precursor of bacterial peptidoglycan. 1 vladimir 0.21902 0.2776 0.286263 0.217099 0.563881 0.436119 0.193084 0.233429 0.40634 0.167147 0.639769 0.360231 0.299712 0.207493 0.18732 0.305476 0.394813 0.605187 0.164265 0.391931 0.26513 0.178674 0.657061 0.342939 0.683133 37892.805 0.003757 0.283237 0.520231 0.245665 0.115607 0.604046 0.395954 0.242775 0.130058 0.112717 6.138512 9.566474 NMV_1586 2192548 CDS +3 1540029 1540673 645 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-24 15:38:41 no Belongs to the TetR family of regulatory proteins. 2 vladimir 0.261137 0.3318 0.208909 0.198157 0.540707 0.459293 0.313364 0.253456 0.276498 0.156682 0.529954 0.470046 0.336406 0.18894 0.165899 0.308756 0.354839 0.645161 0.133641 0.552995 0.184332 0.129032 0.737327 0.262673 0.708322 24859.525 -0.27963 0.236111 0.458333 0.24537 0.125 0.527778 0.472222 0.25 0.138889 0.111111 8.38839 9.537037 NMV_1588 2192550 CDS +3 1540728 1541525 798 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 15:42:02 no 2 vladimir 0.244361 0.3559 0.225564 0.174185 0.581454 0.418546 0.263158 0.327068 0.293233 0.116541 0.620301 0.379699 0.289474 0.236842 0.206767 0.266917 0.443609 0.556391 0.180451 0.503759 0.176692 0.139098 0.680451 0.319549 0.636662 29418.33 -0.277736 0.286792 0.520755 0.226415 0.109434 0.535849 0.464151 0.245283 0.143396 0.101887 7.308205 9.245283 NMV_1589 2192551 CDS +2 1541576 1542142 567 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 15:41:52 no 2 vladimir 0.236332 0.3333 0.275132 0.155203 0.608466 0.391534 0.253968 0.248677 0.391534 0.10582 0.640212 0.359788 0.253968 0.201058 0.248677 0.296296 0.449735 0.550265 0.201058 0.550265 0.185185 0.063492 0.73545 0.26455 0.608546 20010.795 -0.051064 0.345745 0.494681 0.260638 0.042553 0.553191 0.446809 0.260638 0.111702 0.148936 4.750389 8.87234 NMV_1590 2192552 CDS +3 1542162 1543052 891 validated/Curated no nadK NAD kinase (DPN kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.44 : NAD phosphorylation and dephosphorylation ; 2.7.1.23 NAD-KIN-RXN NADPHOS-DEPHOS-PWY 2018-01-24 15:40:45 no Catalyses the following reaction: ATP + NAD(+) <=> ADP + NADP(+). 2 vladimir 0.23569 0.3502 0.222222 0.191919 0.572391 0.427609 0.259259 0.265993 0.329966 0.144781 0.59596 0.40404 0.289562 0.225589 0.171717 0.313131 0.397306 0.602694 0.158249 0.558923 0.164983 0.117845 0.723906 0.276094 0.653897 32851.455 -0.040878 0.283784 0.483108 0.260135 0.108108 0.567568 0.432432 0.22973 0.121622 0.108108 5.929588 9.638514 NMV_1591 2192553 CDS +3 1543077 1543835 759 validated/Curated no rluF 23S rRNA pseudouridine(2604) synthase (ribosomal large subunit pseudouridine synthase F; rRNA-uridine isomerase F; rRNA pseudouridylate synthase F) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.21 RXN-11835 2018-01-23 12:43:02 no Is responsible for the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA. Can, to a small extent, also react with uracil-2605. 2 vladimir 0.267457 0.2780 0.277997 0.176548 0.555995 0.444005 0.241107 0.280632 0.359684 0.118577 0.640316 0.359684 0.332016 0.173913 0.233202 0.26087 0.407115 0.592885 0.229249 0.379447 0.241107 0.150198 0.620553 0.379447 0.645301 28158.395 -0.572222 0.257937 0.448413 0.234127 0.063492 0.52381 0.47619 0.31746 0.198413 0.119048 9.938652 9.452381 NMV_1592 2192554 CDS -3 1543890 1544555 666 validated/Curated no putative NAD(P)H nitroreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.-.-.- R303-RXN 2018-01-22 18:24:52 no 1 vladimir 0.222222 0.2327 0.292793 0.252252 0.525526 0.474474 0.220721 0.162162 0.373874 0.243243 0.536036 0.463964 0.274775 0.247748 0.189189 0.288288 0.436937 0.563063 0.171171 0.288288 0.315315 0.225225 0.603604 0.396396 0.665063 24708.36 -0.09819 0.312217 0.502262 0.190045 0.117647 0.574661 0.425339 0.248869 0.126697 0.122172 6.216591 9.488688 NMV_1593 2192555 CDS -2 1544755 1545528 774 validated/Curated no folE2 GTP cyclohydrolase FolE2 1c : Function from experimental evidences in the studied genus e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 3.5.4.16 GTP-CYCLOHYDRO-I-RXN$GTP-CYCLOHYDRO-II-RXN$RXN-10055$RXN-10063 PWY-6147$PWY-6703$RIBOSYN2-PWY 2018-01-24 15:42:20 no 17032654 Converts GTP to 7,8-dihydroneopterin triphosphate. 1 vladimir 0.245478 0.2636 0.245478 0.245478 0.509044 0.490956 0.263566 0.209302 0.341085 0.186047 0.550388 0.449612 0.325581 0.244186 0.135659 0.294574 0.379845 0.620155 0.147287 0.337209 0.25969 0.255814 0.596899 0.403101 0.670045 28741.78 -0.160311 0.291829 0.498054 0.225681 0.108949 0.529183 0.470817 0.256809 0.132296 0.124514 5.837517 9.470817 NMV_1594 2192556 CDS +3 1545573 1546877 1305 validated/Curated no metC cystathionine beta-lyase (CBL; beta-cystathionase; cysteine lyase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.9 : Methionine ; 4.4.1.13 CYSTATHIONINE-BETA-LYASE-RXN$CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN HOMOSER-METSYN-PWY 2020-02-19 18:47:31 no Catalyses the following reaction: L-cystathionine + H2O <=> L-homocysteine + NH3 + pyruvate. 1 vladimir 0.24266 0.2651 0.263385 0.228843 0.528497 0.471503 0.259067 0.207254 0.367876 0.165803 0.57513 0.42487 0.316062 0.222798 0.15285 0.30829 0.375648 0.624352 0.15285 0.365285 0.26943 0.212435 0.634715 0.365285 0.745287 42230.86 -0.003377 0.288312 0.522078 0.241558 0.116883 0.587013 0.412987 0.246753 0.132468 0.114286 5.919441 9.314286 NMV_1595 2192557 CDS -1 1546940 1547941 1002 validated/Curated no hemB delta-aminolevulinic acid dehydratase (porphobilinogen synthase; ALAD; ALADH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 4.2.1.24 PORPHOBILSYNTH-RXN PWY-5188 2018-01-24 15:44:12 no Catalyses the second step in the biosynthesis of heme: 2 5-aminolevulinate <=> porphobilinogen + 2 H(2)O. 1 vladimir 0.206587 0.2295 0.328343 0.235529 0.557884 0.442116 0.206587 0.206587 0.428144 0.158683 0.634731 0.365269 0.308383 0.245509 0.158683 0.287425 0.404192 0.595808 0.10479 0.236527 0.398204 0.260479 0.634731 0.365269 0.636778 36844.66 -0.227928 0.279279 0.51952 0.21021 0.096096 0.582583 0.417417 0.279279 0.132132 0.147147 5.155952 10.231231 NMV_1596 2192558 CDS -2 1548124 1548408 285 validated/Curated no putative RNA-binding protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2017-10-25 23:59:41 no 12429100 1 vladimir 0.259649 0.2281 0.291228 0.221053 0.519298 0.480702 0.263158 0.221053 0.4 0.115789 0.621053 0.378947 0.336842 0.2 0.147368 0.315789 0.347368 0.652632 0.178947 0.263158 0.326316 0.231579 0.589474 0.410526 0.679014 10474.765 -0.064894 0.255319 0.457447 0.287234 0.074468 0.531915 0.468085 0.329787 0.180851 0.148936 6.203773 9.56383 NMV_1597 2192559 CDS +2 1548518 1549138 621 validated/Curated no rlmE ftsJ ribosomal RNA large subunit methyltransferase E (rRNA (uridine-2'-O-)-methyltransferase; 23S rRNA m2U2552 methyltransferase; cell division protein FtsJ) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.1.166 RXN-11845 2018-01-22 18:53:11 no This enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA. 2 vladimir 0.256039 0.2770 0.257649 0.20934 0.534622 0.465378 0.236715 0.202899 0.362319 0.198068 0.565217 0.434783 0.31401 0.222222 0.183575 0.280193 0.405797 0.594203 0.217391 0.405797 0.227053 0.149758 0.63285 0.36715 0.690485 22720.005 -0.220874 0.31068 0.5 0.203883 0.11165 0.553398 0.446602 0.252427 0.140777 0.11165 7.9338 9.23301 NMV_1598 2192560 CDS +2 1549202 1551169 1968 validated/Curated no ftsH ATP-dependent zinc metalloprotease FtsH (cell division protease FtsH) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 5.1 : Cell division ; 3.4.24.- RXN0-3221 2018-01-23 11:40:32 no Belongs to MEROPS peptidase family M41 (FtsH endopeptidase family, clan MA(E)). FtsH is a membrane-anchored ATP-dependent protease that degrades misfolded or misassembled membrane proteins as well as a subset of cytoplasmic regulatory proteins. 1 vladimir 0.254065 0.2790 0.280488 0.186484 0.559451 0.440549 0.257622 0.216463 0.396341 0.129573 0.612805 0.387195 0.323171 0.208841 0.189024 0.278963 0.397866 0.602134 0.181402 0.411585 0.256098 0.150915 0.667683 0.332317 0.723277 72125.8 -0.37374 0.283969 0.514504 0.206107 0.079389 0.532824 0.467176 0.277863 0.131298 0.146565 5.18351 9.644275 NMV_1599 2192561 CDS +1 1551385 1551822 438 validated/Curated no putative ribosome association toxin RatA 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2020-04-23 18:54:24 no 21323758 Toxic component of a type II toxin-antitoxin system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes. Its antitoxin is unknown. 2 vladimir 0.26484 0.2511 0.246575 0.237443 0.497717 0.502283 0.273973 0.191781 0.328767 0.205479 0.520548 0.479452 0.349315 0.171233 0.143836 0.335616 0.315068 0.684932 0.171233 0.390411 0.267123 0.171233 0.657534 0.342466 0.703827 16901.88 -0.282069 0.193103 0.434483 0.227586 0.144828 0.544828 0.455172 0.310345 0.165517 0.144828 6.492271 9.668966 NMV_1600 2192562 CDS +2 1551815 1552093 279 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 15:39:21 no 2 vladimir 0.261649 0.2832 0.268817 0.18638 0.551971 0.448029 0.215054 0.27957 0.387097 0.11828 0.666667 0.333333 0.344086 0.182796 0.172043 0.301075 0.354839 0.645161 0.225806 0.387097 0.247312 0.139785 0.634409 0.365591 0.686921 10343.465 -0.404348 0.217391 0.445652 0.26087 0.054348 0.532609 0.467391 0.326087 0.152174 0.173913 5.105965 9.695652 NMV_1601 2192563 CDS +3 1552146 1552724 579 validated/Curated no pth peptidyl-tRNA hydrolase (PTH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.1.29 AMINOCYL-TRNA-HYDROLASE-RXN 2018-01-24 15:48:08 no Cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA, which drops off the ribosome during protein synthesis. 2 vladimir 0.272884 0.2988 0.24525 0.183074 0.544041 0.455959 0.253886 0.243523 0.357513 0.145078 0.601036 0.398964 0.34715 0.186529 0.196891 0.26943 0.38342 0.61658 0.217617 0.466321 0.181347 0.134715 0.647668 0.352332 0.665108 21590.815 -0.428646 0.260417 0.458333 0.208333 0.130208 0.552083 0.447917 0.296875 0.171875 0.125 8.894356 9.109375 NMV_1602 2192564 CDS +2 1552784 1552990 207 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 15:38:38 no 1 vladimir 0.2657 0.3188 0.251208 0.164251 0.570048 0.429952 0.217391 0.26087 0.362319 0.15942 0.623188 0.376812 0.318841 0.231884 0.15942 0.289855 0.391304 0.608696 0.26087 0.463768 0.231884 0.043478 0.695652 0.304348 0.673979 7742.555 -0.097059 0.279412 0.411765 0.25 0.073529 0.529412 0.470588 0.294118 0.088235 0.205882 4.202019 9.220588 NMV_1603 2192565 CDS +1 1552987 1553349 363 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 15:38:26 no 2 vladimir 0.176309 0.3444 0.239669 0.239669 0.584022 0.415978 0.206612 0.264463 0.31405 0.214876 0.578512 0.421488 0.165289 0.322314 0.181818 0.330579 0.504132 0.495868 0.157025 0.446281 0.22314 0.173554 0.669421 0.330579 0.652929 13173.075 0.493333 0.358333 0.508333 0.2 0.166667 0.691667 0.308333 0.175 0.116667 0.058333 9.623558 8.433333 NMV_1604 2192566 CDS +3 1553580 1554995 1416 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-24 15:48:45 no Is probably a sodium symporter, which mediates the intake of a molecule with the concomitant uptake of sodium ions. 2 vladimir 0.194209 0.3093 0.247881 0.248588 0.557203 0.442797 0.290254 0.216102 0.32839 0.165254 0.544492 0.455508 0.182203 0.256356 0.131356 0.430085 0.387712 0.612288 0.110169 0.455508 0.283898 0.150424 0.739407 0.260593 0.69992 50645.86 0.947134 0.309979 0.498938 0.324841 0.106157 0.707006 0.292994 0.127389 0.076433 0.050955 8.777611 8.367304 NMV_1605 2192567 CDS +1 1555114 1555623 510 validated/Curated no ppiB rotB peptidyl-prolyl cis-trans isomerase B (PPIase B; rotamase B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 5.2.1.8 PEPTIDYLPROLYL-ISOMERASE-RXN 2018-01-22 17:25:42 no PPIases accelerate the folding of proteins. It catalyses the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 2 vladimir 0.296078 0.3000 0.211765 0.192157 0.511765 0.488235 0.3 0.152941 0.405882 0.141176 0.558824 0.441176 0.388235 0.188235 0.129412 0.294118 0.317647 0.682353 0.2 0.558824 0.1 0.141176 0.658824 0.341176 0.879762 18851.4 -0.351479 0.248521 0.532544 0.201183 0.136095 0.532544 0.467456 0.289941 0.136095 0.153846 5.045296 9.420118 NMV_1606 2192568 CDS +1 1555786 1557168 1383 validated/Curated no pgm phosphoglucomutase (glucose phosphomutase; PGM) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.9 : Misc. glucose metabolism ; 5.4.2.2 PHOSPHOGLUCMUT-RXN GLUCOSE1PMETAB-PWY$GLYCOCAT-PWY 2018-01-24 15:49:44 no Participates in both the breakdown and synthesis of glucose, by catalysing the following reaction: alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate. 2 vladimir 0.263196 0.3080 0.244396 0.184382 0.552422 0.447578 0.29718 0.195228 0.390456 0.117137 0.585683 0.414317 0.310195 0.208243 0.184382 0.29718 0.392625 0.607375 0.182213 0.520607 0.158351 0.138829 0.678959 0.321041 0.753454 49672.585 -0.13 0.302174 0.513043 0.221739 0.093478 0.580435 0.419565 0.256522 0.123913 0.132609 5.2649 9.232609 NMV_1607 2192569 CDS -1 1557188 1557943 756 validated/Curated no putative amino acid ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2018-01-24 15:50:12 no ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. 2 vladimir 0.26455 0.2579 0.271164 0.206349 0.529101 0.470899 0.257937 0.234127 0.361111 0.146825 0.595238 0.404762 0.329365 0.190476 0.154762 0.325397 0.345238 0.654762 0.206349 0.349206 0.297619 0.146825 0.646825 0.353175 0.657206 27963.27 -0.228287 0.23506 0.454183 0.25498 0.079681 0.541833 0.458167 0.282869 0.151394 0.131474 6.679832 9.187251 NMV_1608 2192570 CDS -1 1557953 1558669 717 validated/Curated no putative amino acid ABC transporter permease protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-24 15:50:25 no ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. 1 vladimir 0.182706 0.2636 0.263598 0.290098 0.527197 0.472803 0.23431 0.1841 0.351464 0.230126 0.535565 0.464435 0.179916 0.267782 0.133891 0.41841 0.401674 0.598326 0.133891 0.338912 0.305439 0.221757 0.644351 0.355649 0.724325 26203.355 0.826471 0.285714 0.5 0.306723 0.12605 0.710084 0.289916 0.142857 0.088235 0.054622 9.657204 9.105042 NMV_1609 2192571 CDS -3 1558659 1559483 825 validated/Curated no putative amino acid ABC transporter binding lipoprotein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2015-11-19 18:13:13 no 2 vladimir 0.27657 0.2464 0.283816 0.193237 0.530193 0.469807 0.278986 0.126812 0.442029 0.152174 0.568841 0.431159 0.322464 0.25 0.17029 0.257246 0.42029 0.57971 0.228261 0.362319 0.23913 0.17029 0.601449 0.398551 0.775761 28838.29 -0.175273 0.367273 0.592727 0.214545 0.065455 0.545455 0.454545 0.243636 0.12 0.123636 5.658287 8.632727 NMV_1610 2192572 CDS +2 1559771 1560679 909 validated/Curated no putative deferrochelatase/peroxidase EfeB 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.11.1.- 2018-01-24 15:52:07 no Might be involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. 2 vladimir 0.232123 0.3300 0.256326 0.181518 0.586359 0.413641 0.211221 0.237624 0.389439 0.161716 0.627063 0.372937 0.316832 0.227723 0.191419 0.264026 0.419142 0.580858 0.168317 0.524752 0.188119 0.118812 0.712871 0.287129 0.709734 32785.505 -0.273841 0.321192 0.523179 0.205298 0.109272 0.55298 0.44702 0.264901 0.129139 0.135762 5.27494 9.241722 NMV_1611 2192573 CDS +3 1560759 1564373 3615 validated/Curated no recB exodeoxyribonuclease V beta chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.11.5 RXN0-2605 2018-01-22 15:33:55 no Is a multisubunit enzyme comprised of the proteins RecB, RecC and RecD, which plays an important role in homologous genetic recombination, repair of double strand DNA breaks, resistance to UV irradiation and chemical DNA-damage. The enzyme catalyses hydrolysis of single-stranded (ss) DNA or double-stranded (ds) DNA and unwinding of the ends of dsDNA. Its nuclease activity is controlled by Chi sites (5' G-C-T-G-G-T-G-G 3') in such a way that the enzyme produces a potent single-stranded DNA substrate for homologous pairing by RecA and single-stranded DNA binding proteins. 2 vladimir 0.240664 0.3272 0.252559 0.17953 0.579806 0.420194 0.209129 0.270539 0.363485 0.156846 0.634025 0.365975 0.321992 0.252282 0.170954 0.254772 0.423237 0.576764 0.190871 0.458921 0.223237 0.126971 0.682158 0.317842 0.683147 134670.395 -0.335299 0.297342 0.48505 0.200997 0.111296 0.540698 0.459302 0.274917 0.138704 0.136213 5.673241 9.643688 NMV_1612 2192574 CDS +2 1564412 1564771 360 validated/Curated no putative phage shock protein E 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 8.1 : Prophage genes and phage related functions ; 2018-01-24 15:53:03 no Contains a rhodanese domain. Is induced in E. coli by heat, ethanol, osmotic shock and infection by filamentous bacteriophages. 2 vladimir 0.277778 0.3278 0.230556 0.163889 0.558333 0.441667 0.25 0.275 0.375 0.1 0.65 0.35 0.35 0.275 0.141667 0.233333 0.416667 0.583333 0.233333 0.433333 0.175 0.158333 0.608333 0.391667 0.650573 13019.28 -0.368067 0.302521 0.512605 0.201681 0.10084 0.537815 0.462185 0.268908 0.168067 0.10084 8.806557 9.571429 NMV_1613 2192575 CDS +1 1564903 1565382 480 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-05-01 15:35:51 no 2 vladimir 0.277083 0.3458 0.2125 0.164583 0.558333 0.441667 0.33125 0.225 0.34375 0.1 0.56875 0.43125 0.2625 0.33125 0.13125 0.275 0.4625 0.5375 0.2375 0.48125 0.1625 0.11875 0.64375 0.35625 0.656459 17035.99 -0.024528 0.371069 0.54717 0.213836 0.069182 0.534591 0.465409 0.232704 0.132075 0.100629 8.149345 9.006289 NMV_1614 2192576 CDS -1 1565654 1567033 1380 validated/Curated no radA DNA repair protein RadA (DNA repair protein Sms) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.1.4 : DNA repair ; 3.6.4.- 2018-01-24 15:54:14 no DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. 1 vladimir 0.226812 0.3072 0.276812 0.18913 0.584058 0.415942 0.234783 0.241304 0.380435 0.143478 0.621739 0.378261 0.276087 0.243478 0.18913 0.291304 0.432609 0.567391 0.169565 0.436957 0.26087 0.132609 0.697826 0.302174 0.696841 49587.05 -0.093464 0.318083 0.522876 0.233115 0.063181 0.570806 0.429194 0.230937 0.122004 0.108932 6.74894 9.590414 NMV_1615 2192577 CDS -2 1567219 1568283 1065 validated/Curated no hemE uroporphyrinogen decarboxylase (URO-D; UPD) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 4.1.1.37 UROGENDECARBOX-RXN HEMESYN2-PWY$PWY0-1415 2018-01-24 15:54:41 no Catalyses the following reaction: uroporphyrinogen III <=> coproporphyrinogen + 4 CO(2). 2 vladimir 0.237559 0.3146 0.258216 0.189671 0.57277 0.42723 0.23662 0.233803 0.371831 0.157746 0.605634 0.394366 0.295775 0.214085 0.191549 0.298592 0.405634 0.594366 0.180282 0.495775 0.211268 0.112676 0.707042 0.292958 0.724084 39135.445 -0.10113 0.299435 0.480226 0.220339 0.121469 0.587571 0.412429 0.254237 0.138418 0.115819 6.599937 9.378531 NMV_1616 2192578 CDS -3 1568358 1569575 1218 validated/Curated no putative heme biosynthesis protein HemY 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 1.5.3.12 : Heme, porphyrin ; 2018-01-24 15:59:37 no Is a heme biosynthesis-associated TPR protein (IPR005254). 1 vladimir 0.230706 0.2537 0.295566 0.220033 0.549261 0.450739 0.206897 0.229064 0.389163 0.174877 0.618227 0.381773 0.315271 0.226601 0.167488 0.29064 0.394089 0.605911 0.169951 0.305419 0.330049 0.194581 0.635468 0.364532 0.604724 45313.71 -0.135309 0.281481 0.441975 0.237037 0.103704 0.582716 0.417284 0.274074 0.160494 0.11358 9.517494 9.496296 NMV_1617 2192579 CDS -1 1569572 1570906 1335 validated/Curated no putative uroporphyrinogen-III C-methyltransferase HemX 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.5.3.12 : Heme, porphyrin ; 2.1.1.107 RXN-8675$UROPORIIIMETHYLTRANSA-RXN PWY-5194 2018-01-24 15:57:29 no This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. 1 vladimir 0.26902 0.2714 0.27451 0.185098 0.545882 0.454118 0.230588 0.225882 0.383529 0.16 0.609412 0.390588 0.336471 0.272941 0.143529 0.247059 0.416471 0.583529 0.24 0.315294 0.296471 0.148235 0.611765 0.388235 0.657079 46282.325 -0.437264 0.299528 0.516509 0.216981 0.04717 0.504717 0.495283 0.261792 0.122642 0.139151 5.190453 9.363208 NMV_1618 2192580 CDS -2 1570921 1571661 741 validated/Curated no hemD uroporphyrinogen-III synthase (UROS; uroporphyrinogen-III cosynthetase; hydroxymethylbilane hydrolyase [cyclizing]) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 4.2.1.75 UROGENIIISYN-RXN PWY-5188 2018-01-24 16:00:05 no Catalyses the fourth step in the heme biosynthetic pathway. 1 vladimir 0.217274 0.2659 0.282051 0.234818 0.547908 0.452092 0.214575 0.234818 0.356275 0.194332 0.591093 0.408907 0.263158 0.259109 0.186235 0.291498 0.445344 0.554656 0.174089 0.303644 0.303644 0.218623 0.607287 0.392713 0.620189 27419.275 -0.169106 0.296748 0.512195 0.219512 0.109756 0.54878 0.45122 0.256098 0.138211 0.117886 6.672676 9.634146 NMV_1619 2192581 CDS -3 1571700 1572122 423 validated/Curated no outer-membrane associated protein 1c : Function from experimental evidences in the studied genus ph : phenotype 8 : Outer membrane-associated 2018-01-24 16:00:26 no When mutated in the gonococcus results in a significant increase in toxicity of the strain to human fallopian tube organ cultures. 1 vladimir 0.283688 0.2199 0.271868 0.224586 0.491726 0.508274 0.297872 0.12766 0.361702 0.212766 0.489362 0.510638 0.326241 0.22695 0.205674 0.241135 0.432624 0.567376 0.22695 0.304965 0.248227 0.219858 0.553191 0.446809 0.634185 15840.185 -0.451429 0.335714 0.528571 0.157143 0.135714 0.5 0.5 0.271429 0.15 0.121429 8.91198 9.392857 NMV_1620 2192582 CDS -2 1572373 1572693 321 validated/Curated no conserved hypothetical ANK repeat-containing protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-24 16:00:46 no Contains ankyrin (ANK) repeats, one of the most common protein-protein interaction motifs in nature. 1 vladimir 0.252336 0.2710 0.252336 0.224299 0.523364 0.476636 0.186916 0.271028 0.401869 0.140187 0.672897 0.327103 0.383178 0.214953 0.121495 0.280374 0.336449 0.663551 0.186916 0.327103 0.233645 0.252336 0.560748 0.439252 0.640168 11564.635 -0.248113 0.264151 0.481132 0.235849 0.122642 0.566038 0.433962 0.292453 0.150943 0.141509 5.570915 8.59434 NMV_1621 2192583 CDS -1 1572716 1573342 627 validated/Curated no upp uracil phosphoribosyltransferase (UMP pyrophosphorylase; UPRTase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.4.2.9 URACIL-PRIBOSYLTRANS-RXN P1-PWY$PWY0-163 2018-01-24 16:01:15 no Catalyses the following reaction: UMP + diphosphate <=> uracil + 5-phospho-alpha-D-ribose 1-diphosphate. 2 vladimir 0.239234 0.2775 0.280702 0.202552 0.558214 0.441786 0.301435 0.200957 0.382775 0.114833 0.583732 0.416268 0.296651 0.200957 0.172249 0.330144 0.373206 0.626794 0.119617 0.430622 0.287081 0.162679 0.717703 0.282297 0.674115 22739.565 0.087019 0.278846 0.509615 0.274038 0.076923 0.596154 0.403846 0.269231 0.134615 0.134615 5.610649 9.302885 NMV_1622 2192584 CDS -1 1573448 1573759 312 validated/Curated no putative monothiol glutaredoxin 3 : Putative function from multiple computational evidences c : carrier 2 : Cytoplasmic 2018-01-24 16:01:30 no Glutaredoxins function as electron carriers. 2 vladimir 0.266026 0.2564 0.262821 0.214744 0.519231 0.480769 0.25 0.211538 0.365385 0.173077 0.576923 0.423077 0.336538 0.192308 0.153846 0.317308 0.346154 0.653846 0.211538 0.365385 0.269231 0.153846 0.634615 0.365385 0.74111 11523.73 -0.08835 0.262136 0.485437 0.242718 0.106796 0.563107 0.436893 0.223301 0.097087 0.126214 4.853142 9.84466 NMV_1623 2192585 CDS -2 1574101 1574880 780 validated/Curated no putative metal-dependent deoxyribonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.21.- 2018-01-23 11:01:03 no Is related to TatD, a member of a large superfamily of metalloenzymes, which has been shown experimentally to be a DNase. 1 vladimir 0.244872 0.2705 0.258974 0.225641 0.529487 0.470513 0.230769 0.192308 0.388462 0.188462 0.580769 0.419231 0.319231 0.246154 0.15 0.284615 0.396154 0.603846 0.184615 0.373077 0.238462 0.203846 0.611538 0.388462 0.683752 28799.61 -0.1139 0.293436 0.501931 0.216216 0.135135 0.559846 0.440154 0.274131 0.138996 0.135135 5.525841 9.741313 NMV_1624 2192586 CDS -1 1574885 1575235 351 validated/Curated no pilZ PilZ protein 1a : Function from experimental evidences in the studied strain f : factor 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-26 10:37:09 no 15612916 Unlike in P. aeruginosa, it is not required for pilus biogenesis in N. meningitidis, but it modulates pilus-mediated properties. 2 vladimir 0.287749 0.2650 0.225071 0.222222 0.490029 0.509972 0.333333 0.222222 0.273504 0.17094 0.495727 0.504274 0.307692 0.213675 0.128205 0.350427 0.34188 0.65812 0.222222 0.358974 0.273504 0.145299 0.632479 0.367521 0.692805 12861.465 -0.00431 0.258621 0.491379 0.241379 0.103448 0.568966 0.431034 0.206897 0.112069 0.094828 6.714333 8.586207 NMV_1625 2192587 CDS -1 1575239 1576216 978 validated/Curated no holB DNA polymerase III delta' subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:22:05 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 1 vladimir 0.236196 0.2321 0.283231 0.248466 0.515337 0.484663 0.220859 0.251534 0.328221 0.199387 0.579755 0.420245 0.315951 0.208589 0.168712 0.306748 0.377301 0.622699 0.171779 0.236196 0.352761 0.239264 0.588957 0.411043 0.602026 36999.74 -0.158154 0.227692 0.433846 0.243077 0.123077 0.593846 0.406154 0.28 0.156923 0.123077 7.28257 9.541538 NMV_1626 2192588 CDS -1 1576250 1577380 1131 validated/Curated no pilT2 PilT-like protein PilT2 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-25 14:36:34 no Cytosolic ATPase that belongs to the PilT subfamily of proteins. Not required for pilus biogenesis, but modulates pilus-mediated functions. 2 vladimir 0.255166 0.2803 0.25876 0.20575 0.539084 0.460916 0.301887 0.237197 0.304582 0.156334 0.541779 0.458221 0.312668 0.229111 0.150943 0.307278 0.380054 0.619946 0.150943 0.374663 0.320755 0.153639 0.695418 0.304582 0.665404 41475.965 -0.218378 0.278378 0.462162 0.232432 0.091892 0.502703 0.497297 0.27027 0.143243 0.127027 6.160942 9.143243 NMV_1627 2192589 CDS +1 1577548 1578249 702 validated/Curated no mtnN pfs 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.20 : S-adenosyl methionine biosynthesis ; 1.7.33 : Nucleotide and nucleoside conversions ; 3.2.2.9 ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN PWY-6151$PWY-6153 2018-01-30 14:31:10 no Catalyses the following reactions: S-adenosyl-L-homocysteine + H(2)O <=> S-(5-deoxy-D-ribose-5-yl)-L-homocysteine + adenine and S-methyl-5'-thioadenosine + H(2)O <=> 5-methyl-5-thio-D-ribose + adenine. 1 vladimir 0.254986 0.2393 0.296296 0.209402 0.535613 0.464387 0.235043 0.119658 0.491453 0.153846 0.611111 0.388889 0.273504 0.235043 0.162393 0.32906 0.397436 0.602564 0.25641 0.363248 0.235043 0.145299 0.598291 0.401709 0.739078 24606.37 0.334764 0.343348 0.549356 0.253219 0.085837 0.618026 0.381974 0.244635 0.11588 0.128755 5.198357 9.103004 NMV_1628 2192590 CDS +2 1578392 1580185 1794 validated/Curated no lepA elongation factor 4 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2020-02-19 13:06:14 no Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to ribosomes in a GTP-dependent manner. 2 vladimir 0.261984 0.2419 0.266444 0.229654 0.508361 0.491639 0.26087 0.19398 0.386288 0.158863 0.580268 0.419732 0.337793 0.188963 0.145485 0.327759 0.334448 0.665552 0.187291 0.342809 0.267559 0.202341 0.610368 0.389632 0.742976 65971.36 -0.08258 0.252931 0.487437 0.268007 0.073702 0.549414 0.450586 0.264657 0.127303 0.137353 5.312965 9.236181 NMV_1629 2192591 CDS +3 1580328 1581347 1020 validated/Curated no lepB signal peptidase I (SPase I; leader peptidase I) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 2.3.5 : Export, signal peptide cleavage ; 3.4.21.89 3.4.21.89-RXN 2018-01-24 16:05:40 no Belongs to MEROPS peptidase family S26 (signal peptidase I family, clan SF), subfamily S26A. Catalyses the cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. 1 vladimir 0.228431 0.2520 0.255882 0.263725 0.507843 0.492157 0.264706 0.164706 0.344118 0.226471 0.508824 0.491176 0.279412 0.197059 0.194118 0.329412 0.391176 0.608824 0.141176 0.394118 0.229412 0.235294 0.623529 0.376471 0.687805 37585.65 0.027729 0.289086 0.519174 0.224189 0.144543 0.60767 0.39233 0.215339 0.109145 0.106195 5.891563 9.097345 NMV_1630 2192592 CDS -2 1581502 1582407 906 validated/Curated no putative amino acid metabolite efflux pump 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2020-04-20 20:30:36 no 1 vladimir 0.164972 0.2260 0.318644 0.290395 0.544633 0.455367 0.189831 0.186441 0.376271 0.247458 0.562712 0.437288 0.155932 0.233898 0.189831 0.420339 0.423729 0.576271 0.149153 0.257627 0.38983 0.20339 0.647458 0.352542 0.600099 31275.955 0.977551 0.340136 0.520408 0.323129 0.139456 0.741497 0.258503 0.112245 0.07483 0.037415 9.463341 8.180272 NMNmiscRNA0169 54919402 misc_RNA -1 1582673 1582858 186 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:02:49 28334889 Function unknown. Very abundant RNA. vladimir NMV_1631 2192593 CDS -1 1582973 1583905 933 validated/Curated no cysK cysteine synthase (O-acetylserine sulfhydrylase A; O-acetylserine (thiol)-lyase A; CSase A) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.12 : Cysteine ; 2.5.1.47 ACSERLY-RXN$LCYSDESULF-RXN CYSTSYN-PWY$LCYSDEG-PWY 2018-01-24 16:06:26 no Catalyses the following reaction: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate. 1 vladimir 0.264737 0.2497 0.281886 0.203644 0.531618 0.468382 0.308682 0.151125 0.421222 0.118971 0.572347 0.427653 0.282958 0.26045 0.167203 0.289389 0.427653 0.572347 0.202572 0.337621 0.257235 0.202572 0.594855 0.405145 0.731242 32833.545 0.009355 0.33871 0.541935 0.235484 0.064516 0.590323 0.409677 0.241935 0.122581 0.119355 6.086067 9.154839 NMV_1632 2192594 CDS -3 1584099 1584704 606 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:22:10 no 1 vladimir 0.168317 0.2195 0.30033 0.311881 0.519802 0.480198 0.183168 0.247525 0.29703 0.272277 0.544554 0.455446 0.163366 0.207921 0.188119 0.440594 0.39604 0.60396 0.158416 0.20297 0.415842 0.222772 0.618812 0.381188 0.50798 22405 0.950746 0.288557 0.447761 0.313433 0.18408 0.746269 0.253731 0.114428 0.084577 0.029851 9.369453 8.477612 NMV_1633 2192595 CDS -1 1584701 1585552 852 validated/Curated no dapF diaminopimelate epimerase (DAP epimerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 5.1.1.7 DIAMINOPIMEPIM-RXN DAPLYSINESYN-PWY 2018-01-24 16:06:52 no Catalyses the following reaction in the biosynthetic pathway leading from aspartate to lysine: LL-2,6-diaminoheptanedioate <=> meso-diaminoheptanedioate. 1 vladimir 0.197183 0.2218 0.336854 0.244131 0.558685 0.441315 0.211268 0.15493 0.461268 0.172535 0.616197 0.383803 0.257042 0.204225 0.228873 0.309859 0.433099 0.566901 0.123239 0.306338 0.320423 0.25 0.626761 0.373239 0.664677 30333.31 0.04735 0.321555 0.586572 0.219081 0.091873 0.618375 0.381625 0.236749 0.09894 0.137809 4.693886 10.318021 NMV_1634 2192596 CDS +3 1585689 1585985 297 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 15:21:30 no 2 vladimir 0.259259 0.2997 0.198653 0.242424 0.498316 0.501684 0.282828 0.232323 0.272727 0.212121 0.505051 0.494949 0.262626 0.242424 0.191919 0.30303 0.434343 0.565657 0.232323 0.424242 0.131313 0.212121 0.555556 0.444444 0.593921 10583.915 0.243878 0.326531 0.540816 0.234694 0.112245 0.642857 0.357143 0.163265 0.112245 0.05102 8.955025 9.142857 NMV_1635 2192597 CDS +1 1585999 1586667 669 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2020-04-23 18:57:56 no Integral membrane protein belonging to a family named after UreH, an urease accessory protein in Helicobacter pylori. This entry represents a transmembrane domain found in UreH. 1 vladimir 0.219731 0.2780 0.243647 0.258595 0.521674 0.478326 0.264574 0.269058 0.237668 0.2287 0.506726 0.493274 0.165919 0.197309 0.2287 0.408072 0.426009 0.573991 0.2287 0.367713 0.264574 0.139013 0.632287 0.367713 0.476388 24042.955 0.895495 0.328829 0.454955 0.351351 0.117117 0.720721 0.279279 0.09009 0.076577 0.013514 9.825111 7.905405 NMV_1636 2192598 CDS -3 1586739 1588859 2121 validated/Curated no pnp polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase; PNPase; CAP87K) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 2.7.7.8 2.7.7.8-RXN$RXN0-6479 PWY0-1479 2018-01-24 16:09:26 no Is part of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation. 2 vladimir 0.254597 0.2654 0.269684 0.210278 0.535125 0.464875 0.264498 0.178218 0.428571 0.128713 0.606789 0.393211 0.304102 0.243281 0.154173 0.298444 0.397454 0.602546 0.195191 0.374823 0.226308 0.203678 0.601132 0.398868 0.837559 76275.185 -0.078895 0.305949 0.524079 0.247875 0.069405 0.558074 0.441926 0.267705 0.130312 0.137394 5.378975 9.451841 NMV_1637 2192599 CDS -1 1589096 1589959 864 validated/Curated no purC phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.2.6 SAICARSYN-RXN PWY-6123 2018-01-24 16:10:07 no Catalyses the seventh step in the de novo purine biosynthetic pathway: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate <=> ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. 1 vladimir 0.274306 0.2176 0.267361 0.240741 0.484954 0.515046 0.270833 0.190972 0.371528 0.166667 0.5625 0.4375 0.347222 0.21875 0.15625 0.277778 0.375 0.625 0.204861 0.243056 0.274306 0.277778 0.517361 0.482639 0.721607 32221.6 -0.349477 0.261324 0.484321 0.219512 0.097561 0.533101 0.466899 0.292683 0.139373 0.15331 5.251228 9.195122 NMV_1638 2192600 CDS +3 1590159 1591022 864 validated/Curated no rfbD dTDP-4-dehydrorhamnose reductase (dTDP-4-keto- L-rhamnose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.1 : O antigen ; 1.1.1.133 DTDPDEHYRHAMREDUCT-RXN DTDPRHAMSYN-PWY$OANTIGEN-PWY 2020-02-21 16:13:41 no Catalyses the last of 4 steps in the biosynthesis of dTDP-rhamnose, which is a key component of the bacterial cell wall: dTDP-6-deoxy-L-mannose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-L-mannose + NADPH. 2 vladimir 0.238426 0.3264 0.226852 0.208333 0.553241 0.446759 0.232639 0.225694 0.34375 0.197917 0.569444 0.430556 0.295139 0.3125 0.149306 0.243056 0.461806 0.538194 0.1875 0.440972 0.1875 0.184028 0.628472 0.371528 0.652562 31441.25 -0.187108 0.344948 0.550523 0.195122 0.114983 0.550523 0.449477 0.219512 0.114983 0.10453 6.089485 9.15331 NMV_1640 2192602 CDS -1 1591547 1591780 234 validated/Curated no putative thioredoxin 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 16:11:02 no Presents similarities to glutaredoxin 2 family. 1 vladimir 0.277778 0.1581 0.277778 0.286325 0.435897 0.564103 0.192308 0.179487 0.358974 0.269231 0.538462 0.461538 0.423077 0.076923 0.153846 0.346154 0.230769 0.769231 0.217949 0.217949 0.320513 0.24359 0.538462 0.461538 0.661621 9240.3 -0.351948 0.12987 0.363636 0.246753 0.142857 0.545455 0.454545 0.363636 0.142857 0.220779 4.586433 10.363636 NMV_1642 2192604 CDS -1 1591946 1592146 201 validated/Curated no putative bacterioferritin-associated ferredoxin 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 16:11:23 no The function of bacterioferritin-associated ferredoxin (BFD) is not known, but it may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria. 1 vladimir 0.208955 0.2736 0.298507 0.218905 0.572139 0.427861 0.268657 0.149254 0.38806 0.19403 0.537313 0.462687 0.238806 0.313433 0.19403 0.253731 0.507463 0.492537 0.119403 0.358209 0.313433 0.208955 0.671642 0.328358 0.675261 6658.325 0.527273 0.5 0.666667 0.19697 0.060606 0.621212 0.378788 0.106061 0.045455 0.060606 4.724113 10.090909 NMV_1643 2192605 CDS -1 1592318 1593193 876 validated/Curated no xerD tyrosine recombinase XerD 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2020-02-21 17:05:19 no Site-specific tyrosine recombinase, which acts by catalysing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex converts dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. 1 vladimir 0.242009 0.2329 0.312785 0.212329 0.545662 0.454338 0.263699 0.25 0.325342 0.160959 0.575342 0.424658 0.315068 0.19863 0.215753 0.270548 0.414384 0.585616 0.14726 0.25 0.39726 0.205479 0.64726 0.35274 0.539483 33003.54 -0.44055 0.271478 0.457045 0.233677 0.092784 0.512027 0.487973 0.295533 0.175258 0.120275 9.199623 9.773196 NMV_1644 2192606 CDS -1 1593245 1593685 441 validated/Curated no putative peroxiredoxin Bcp (thioredoxin reductase; bacterioferritin comigratory protein homolog) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.11.1.15 2018-01-24 16:12:27 no Catalyses the following reaction: 2 R'-SH + ROOH <=> R'-S-S-R' + H(2)O + ROH. 1 vladimir 0.249433 0.1950 0.297052 0.258503 0.492063 0.507937 0.22449 0.176871 0.367347 0.231293 0.544218 0.455782 0.353741 0.176871 0.183673 0.285714 0.360544 0.639456 0.170068 0.231293 0.340136 0.258503 0.571429 0.428571 0.608843 16493.095 -0.332877 0.280822 0.472603 0.212329 0.143836 0.513699 0.486301 0.315068 0.164384 0.150685 5.966972 9.068493 NMV_1645 2192607 CDS +2 1594109 1595047 939 validated/Curated no pbpG D-alanyl-D-alanine endopeptidase PbpG (D-alanyl-D-alanine carboxypeptidase; DD-peptidase; DD-carboxypeptidase) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.4.16.4 RXN0-3461 2018-02-01 18:04:10 no Involved in cell wall formation. May play a specialised role in remodeling the cell wall. Specifically hydrolyses the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi. 2 vladimir 0.27689 0.3259 0.208733 0.188498 0.534611 0.465389 0.348243 0.239617 0.261981 0.15016 0.501597 0.498403 0.28754 0.268371 0.153355 0.290735 0.421725 0.578275 0.194888 0.469649 0.210863 0.124601 0.680511 0.319489 0.640566 34164.715 -0.185256 0.326923 0.519231 0.227564 0.067308 0.50641 0.49359 0.179487 0.108974 0.070513 9.515785 9.102564 NMV_1646 2192608 CDS +1 1595176 1595469 294 validated/Curated no hfq RNA-binding protein Hfq 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.7 : Nucleoproteins, basic proteins ; 2018-01-24 16:13:58 no Is a RNA-binding pleiotropic regulator. It helps pair regulatory non-coding RNAs with complementary mRNA target regions. It enhances the elongation of poly(A) tails on mRNA. It also appears to protect RNase E recognition sites (A/U-rich sequences with adjacent stem-loop structures) from cleavage. 2 vladimir 0.285714 0.2959 0.190476 0.227891 0.486395 0.513605 0.255102 0.285714 0.306122 0.153061 0.591837 0.408163 0.346939 0.265306 0.071429 0.316327 0.336735 0.663265 0.255102 0.336735 0.193878 0.214286 0.530612 0.469388 0.666369 10841.02 -0.179381 0.237113 0.505155 0.268041 0.082474 0.515464 0.484536 0.185567 0.113402 0.072165 8.407936 9.515464 NMV_1647 2192609 CDS +1 1595554 1596120 567 validated/Curated no putative rRNA methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-01 14:04:21 no 2 vladimir 0.283951 0.2928 0.223986 0.199295 0.516755 0.483245 0.248677 0.296296 0.306878 0.148148 0.603175 0.396825 0.328042 0.21164 0.185185 0.275132 0.396825 0.603175 0.275132 0.37037 0.179894 0.174603 0.550265 0.449735 0.594999 20926.225 -0.26117 0.281915 0.452128 0.223404 0.111702 0.569149 0.430851 0.228723 0.132979 0.095745 8.457603 9.303191 NMV_1649 2192611 CDS +3 1596174 1596548 375 validated/Curated no putative SirB-like protein 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-24 16:14:33 no SirB up-regulates transcription of S. typhimurium invasion genes. 2 vladimir 0.221333 0.2880 0.194667 0.296 0.482667 0.517333 0.32 0.264 0.184 0.232 0.448 0.552 0.208 0.208 0.136 0.448 0.344 0.656 0.136 0.392 0.264 0.208 0.656 0.344 0.667336 14506.335 0.780645 0.217742 0.387097 0.314516 0.177419 0.709677 0.290323 0.145161 0.129032 0.016129 9.971764 8.814516 NMV_1650 2192612 CDS +3 1596558 1597052 495 validated/Curated no folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 2.7.6.3 H2PTERIDINEPYROPHOSPHOKIN-RXN PWY-6147 2018-01-24 16:14:54 no Catalyses the first step in a three-step pathway leading to 7,8 dihydrofolate: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. 2 vladimir 0.230303 0.3212 0.218182 0.230303 0.539394 0.460606 0.236364 0.290909 0.321212 0.151515 0.612121 0.387879 0.30303 0.242424 0.157576 0.29697 0.4 0.6 0.151515 0.430303 0.175758 0.242424 0.606061 0.393939 0.661473 18160.875 -0.259146 0.262195 0.512195 0.243902 0.091463 0.52439 0.47561 0.268293 0.134146 0.134146 5.441566 9.195122 NMV_1651 2192613 CDS -1 1597181 1597660 480 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 14:03:45 no 1 vladimir 0.233333 0.2042 0.289583 0.272917 0.49375 0.50625 0.23125 0.20625 0.33125 0.23125 0.5375 0.4625 0.31875 0.175 0.20625 0.3 0.38125 0.61875 0.15 0.23125 0.33125 0.2875 0.5625 0.4375 0.528345 18024.04 -0.171069 0.264151 0.465409 0.264151 0.100629 0.540881 0.459119 0.283019 0.150943 0.132075 6.99984 9.36478 NMV_1652 2192614 CDS -1 1597880 1598617 738 validated/Curated no ubiE bifunctional ubiquinone/menaquinone biosynthesis methyltransferase UbiE [includes 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 2.1.1.163, 2.1.1.201 2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN$ADOMET-DMK-METHYLTRANSFER-RXN MENAQUINONESYN-PWY$PWY-6708 2018-01-22 18:57:45 no Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). 1 vladimir 0.254743 0.2127 0.289973 0.242547 0.50271 0.49729 0.276423 0.166667 0.365854 0.191057 0.53252 0.46748 0.345528 0.186992 0.150407 0.317073 0.337398 0.662602 0.142276 0.284553 0.353659 0.219512 0.638211 0.361789 0.640269 27370.38 -0.197959 0.265306 0.481633 0.216327 0.138776 0.563265 0.436735 0.281633 0.159184 0.122449 7.294212 9.032653 NMV_1653 2192615 CDS -1 1598660 1599028 369 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-19 18:08:30 no 1 vladimir 0.239186 0.1959 0.292621 0.272265 0.48855 0.51145 0.183206 0.198473 0.366412 0.251908 0.564886 0.435115 0.358779 0.198473 0.183206 0.259542 0.381679 0.618321 0.175573 0.19084 0.328244 0.305344 0.519084 0.480916 0.629331 14641.965 -0.320769 0.269231 0.492308 0.223077 0.138462 0.576923 0.423077 0.253846 0.123077 0.130769 5.272804 9.607692 NMV_1654 2192616 CDS +1 1599148 1600767 1620 validated/Curated no putative tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-30 15:52:15 no Catalyses the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at the wobble position (U34) in tRNA. Catalyses the FAD-dependent demodification of cmnm5s2U34 to nm5s2U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm5s2U34, to form mnm5s2U34. 2 vladimir 0.252469 0.3883 0.200617 0.158642 0.588889 0.411111 0.238889 0.340741 0.27963 0.140741 0.62037 0.37963 0.307407 0.27963 0.177778 0.235185 0.457407 0.542593 0.211111 0.544444 0.144444 0.1 0.688889 0.311111 0.640007 59692.41 -0.338961 0.309833 0.495362 0.209647 0.135436 0.541744 0.458256 0.241187 0.152134 0.089054 6.906273 9.307978 NMV_1657 2192619 CDS +1 1601497 1602504 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-24 16:18:45 no Belongs to the IS5 family. 2 vladimir 0.287698 0.3006 0.223214 0.188492 0.52381 0.47619 0.285714 0.28869 0.267857 0.157738 0.556548 0.443452 0.372024 0.205357 0.178571 0.244048 0.383929 0.616071 0.205357 0.407738 0.223214 0.16369 0.630952 0.369048 0.675318 38481.62 -0.608955 0.268657 0.420896 0.2 0.119403 0.477612 0.522388 0.298507 0.191045 0.107463 9.514824 9.220896 NMV_tRNA_43 2194858 tRNA -1 1602747 1602821 75 validated/Curated no Glu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:56:53 no tRNA Glu anticodon TTC. vladimir NMV_tRNA_42 2194857 tRNA -1 1602839 1602915 77 validated/Curated no Arg tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:57:03 no tRNA Arg anticodon ACG. vladimir NMV_1658 2192620 CDS -1 1603025 1604698 1674 validated/Curated no recN DNA repair protein RecN (recombination protein N) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.1.4 : DNA repair ; 2018-01-24 16:20:33 no Is thought to be DNA damage-inducible and involved in recombinational processes. 1 vladimir 0.26583 0.2509 0.271804 0.21147 0.5227 0.4773 0.236559 0.249104 0.385305 0.129032 0.634409 0.365591 0.349462 0.197133 0.177419 0.275986 0.374552 0.625448 0.21147 0.306452 0.252688 0.229391 0.55914 0.44086 0.636203 61183.49 -0.309874 0.290844 0.454219 0.235189 0.077199 0.509874 0.490126 0.27289 0.131059 0.141831 5.239479 9.310592 NMV_1659 2192621 CDS -1 1604882 1605484 603 validated/Curated no scpB segregation and condensation protein B 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2018-01-24 16:21:01 no Interacts with SMC in vivo forming a complex that is required for chromosome condensation and segregation. 2 vladimir 0.237148 0.2653 0.306799 0.190713 0.572139 0.427861 0.228856 0.288557 0.333333 0.149254 0.621891 0.378109 0.288557 0.263682 0.154229 0.293532 0.41791 0.58209 0.19403 0.243781 0.432836 0.129353 0.676617 0.323383 0.649044 22395.745 -0.2635 0.265 0.47 0.255 0.055 0.52 0.48 0.25 0.095 0.155 4.507927 9.47 NMV_1660 2192622 CDS -3 1605585 1606526 942 validated/Curated no rbgA ribosome biogenesis GTPase A 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; 2018-01-30 15:10:55 no Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. 2 vladimir 0.302548 0.3238 0.225053 0.14862 0.548832 0.451168 0.299363 0.251592 0.33758 0.111465 0.589172 0.410828 0.353503 0.216561 0.194268 0.235669 0.410828 0.589172 0.254777 0.503185 0.143312 0.098726 0.646497 0.353503 0.662987 35315.16 -0.625559 0.265176 0.447284 0.194888 0.083067 0.517572 0.482428 0.316294 0.182109 0.134185 9.33709 9.386581 NMV_1661 2192623 CDS -3 1606608 1607462 855 validated/Curated no putative nucleotide-binding protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-24 16:23:33 no 1 vladimir 0.232749 0.2316 0.297076 0.238596 0.528655 0.471345 0.221053 0.242105 0.340351 0.196491 0.582456 0.417544 0.315789 0.164912 0.207018 0.312281 0.37193 0.62807 0.161404 0.287719 0.34386 0.207018 0.631579 0.368421 0.573009 32730.275 -0.334507 0.225352 0.43662 0.25 0.109155 0.53169 0.46831 0.295775 0.151408 0.144366 5.877892 9.897887 NMV_1662 2192624 CDS -2 1607443 1608405 963 validated/Curated no hprK HPr kinase/phosphorylase (HPrK/P; HPr(Ser) kinase/phosphorylase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.7.11.-, 2.7.4.- 2018-01-22 20:05:32 no This kinase is the sensor in a multicomponent phosphorelay system, which is in control of carbon catabolic repression. 2 vladimir 0.228453 0.2741 0.259605 0.237799 0.533749 0.466251 0.227414 0.274143 0.336449 0.161994 0.610592 0.389408 0.311526 0.17757 0.17134 0.339564 0.34891 0.65109 0.146417 0.370717 0.271028 0.211838 0.641745 0.358255 0.63265 35797.645 -0.095313 0.2375 0.4625 0.29375 0.0875 0.540625 0.459375 0.265625 0.134375 0.13125 5.648781 9.2375 NMV_1663 2192625 CDS -1 1608407 1608856 450 validated/Curated no ptsN PTS system EIIA component 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 4.4.A : Phosphotransferase Systems (PEP-dependent PTS) ; 2.7.1.- 2020-02-26 12:19:12 no Is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase systems (PTS). The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I (EI). Phospho-HPr then transfers it to the permease known as enzyme 2 (EII), which transports the sugar into the cell. 1 vladimir 0.222222 0.2489 0.277778 0.251111 0.526667 0.473333 0.213333 0.206667 0.386667 0.193333 0.593333 0.406667 0.26 0.233333 0.173333 0.333333 0.406667 0.593333 0.193333 0.306667 0.273333 0.226667 0.58 0.42 0.670273 16090.94 0.072483 0.315436 0.463087 0.268456 0.080537 0.557047 0.442953 0.281879 0.14094 0.14094 5.554039 8.61745 NMV_1664 2192626 CDS -3 1609041 1609931 891 validated/Curated no ubiA 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 2.5.1.39 4OHBENZOATE-OCTAPRENYLTRANSFER-RXN PWY-6708 2020-04-22 19:04:11 no Catalyses the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. 1 vladimir 0.188552 0.2649 0.265993 0.280584 0.530864 0.469136 0.228956 0.228956 0.313131 0.228956 0.542088 0.457912 0.195286 0.265993 0.164983 0.373737 0.430976 0.569024 0.141414 0.299663 0.319865 0.239057 0.619529 0.380471 0.656611 33135.175 0.633446 0.300676 0.476351 0.27027 0.155405 0.706081 0.293919 0.162162 0.101351 0.060811 9.398399 8.885135 NMV_1665 2192627 CDS -1 1609961 1610437 477 validated/Curated no putative chorismate pyruvate-lyase UbiC 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 4.1.3.40 ANTHRANSYN-RXN$CHORPYRLY-RXN PWY-5755$TRPSYN-PWY 2018-01-24 16:26:30 no Catalyses the following reaction: chorismate <=> 4-hydroxybenzoate + pyruvate. 1 vladimir 0.180294 0.2453 0.32914 0.245283 0.574423 0.425577 0.144654 0.251572 0.36478 0.238994 0.616352 0.383648 0.226415 0.213836 0.245283 0.314465 0.459119 0.540881 0.169811 0.27044 0.377358 0.18239 0.647799 0.352201 0.576013 17667.835 -0.037342 0.303797 0.436709 0.234177 0.107595 0.594937 0.405063 0.291139 0.151899 0.139241 6.374031 9.607595 NMV_1666 2192628 CDS -2 1610452 1611099 648 validated/Curated no bioD ATP-dependent dethiobiotin synthetase (dethiobiotin synthase; DTB synthetase; DTBS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 6.3.3.3 DETHIOBIOTIN-SYN-RXN PWY0-1507 2018-01-24 16:27:16 no Is involved in biotin biosynthesis and catalyses the following reaction: ATP + 7,8-diaminononanoate + CO(2) <=> ADP + phosphate + dethiobiotin 2 vladimir 0.273148 0.2716 0.246914 0.208333 0.518519 0.481481 0.287037 0.217593 0.347222 0.148148 0.564815 0.435185 0.328704 0.199074 0.166667 0.305556 0.365741 0.634259 0.203704 0.398148 0.226852 0.171296 0.625 0.375 0.687624 23651.28 -0.065581 0.293023 0.47907 0.251163 0.093023 0.553488 0.446512 0.246512 0.130233 0.116279 5.962486 8.902326 NMV_1667 2192629 CDS -3 1611096 1612397 1302 validated/Curated no bioA adenosylmethionine-8-amino-7-oxononanoate aminotransferase (7,8-diamino-pelargonic acid aminotransferase; DAPA aminotransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 2.6.1.62 DAPASYN-RXN PWY0-1507 2018-01-24 16:28:07 no Catalyses the following reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate. 1 vladimir 0.209677 0.2312 0.30722 0.25192 0.538402 0.461598 0.221198 0.214286 0.368664 0.195853 0.582949 0.417051 0.28341 0.218894 0.184332 0.313364 0.403226 0.596774 0.124424 0.260369 0.368664 0.246544 0.629032 0.370968 0.669484 47956.38 0.020092 0.290993 0.496536 0.235566 0.127021 0.600462 0.399538 0.242494 0.13164 0.110855 6.098457 9.535797 NMV_1669 2192631 CDS -2 1612609 1612848 240 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 13:59:23 no 1 vladimir 0.208333 0.1500 0.3125 0.329167 0.4625 0.5375 0.3125 0.0875 0.3625 0.2375 0.45 0.55 0.2375 0.2125 0.1625 0.3875 0.375 0.625 0.075 0.15 0.4125 0.3625 0.5625 0.4375 0.618014 8992.37 0.603797 0.240506 0.518987 0.253165 0.126582 0.708861 0.291139 0.189873 0.075949 0.113924 4.598396 10.632911 NMV_1670 2192632 CDS -1 1613108 1613593 486 validated/Curated no putative FxsA-like protein 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-24 16:28:36 no The molecular function of FxsA is unknown, but in E. coli its overexpression has been shown to alleviate the exclusion of phage T7 in those cells with an F plasmid. 1 vladimir 0.191358 0.1831 0.343621 0.281893 0.526749 0.473251 0.216049 0.141975 0.395062 0.246914 0.537037 0.462963 0.203704 0.191358 0.234568 0.37037 0.425926 0.574074 0.154321 0.216049 0.401235 0.228395 0.617284 0.382716 0.602952 17513.69 0.41677 0.322981 0.490683 0.254658 0.130435 0.68323 0.31677 0.180124 0.093168 0.086957 6.146843 9.354037 NMV_1671 2192633 CDS -2 1613923 1614231 309 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 13:58:58 no 1 vladimir 0.236246 0.2071 0.31068 0.245955 0.517799 0.482201 0.184466 0.203883 0.38835 0.223301 0.592233 0.407767 0.349515 0.165049 0.203883 0.281553 0.368932 0.631068 0.174757 0.252427 0.339806 0.23301 0.592233 0.407767 0.699819 11273.305 -0.269608 0.27451 0.509804 0.245098 0.107843 0.568627 0.431373 0.264706 0.117647 0.147059 4.823448 9.352941 NMV_1672 2192634 CDS -1 1614215 1614517 303 validated/Curated no ihfA himA integration host factor alpha subunit (IHF-alpha) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2020-04-22 16:11:02 no This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. 2 vladimir 0.320132 0.2574 0.224422 0.19802 0.481848 0.518152 0.336634 0.207921 0.336634 0.118812 0.544554 0.455446 0.366337 0.178218 0.178218 0.277228 0.356436 0.643564 0.257426 0.386139 0.158416 0.19802 0.544554 0.455446 0.758804 11421.615 -0.623 0.24 0.45 0.21 0.09 0.45 0.55 0.34 0.19 0.15 8.971901 9.29 NMV_1673 2192635 CDS -3 1614591 1616954 2364 validated/Curated no pheT phenylalanine-tRNA ligase beta chain (phenylalanyl-tRNA synthetase beta chain; PheRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.20 PHENYLALANINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:52:30 no Is composed of alpha and beta chains. Catalyses the attachment of phenylalanine to its cognate transfer RNA molecule in a highly specific two-step reaction. 1 vladimir 0.228426 0.2542 0.306684 0.21066 0.560914 0.439086 0.225888 0.211929 0.409898 0.152284 0.621827 0.378173 0.296954 0.222081 0.185279 0.295685 0.40736 0.59264 0.162437 0.32868 0.324873 0.18401 0.653553 0.346447 0.717021 85830.62 -0.122363 0.29352 0.520966 0.238882 0.07878 0.573062 0.426938 0.256671 0.120712 0.135959 5.157127 9.630241 NMV_1674 2192636 CDS -1 1616990 1617508 519 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 13:58:18 no 3 vladimir 0.371869 0.1156 0.190751 0.321773 0.306358 0.693642 0.369942 0.144509 0.254335 0.231214 0.398844 0.601156 0.369942 0.127168 0.144509 0.358382 0.271676 0.728324 0.375723 0.075145 0.17341 0.375723 0.248555 0.751445 0.470413 20051.405 -0.13314 0.174419 0.366279 0.30814 0.093023 0.517442 0.482558 0.25 0.110465 0.139535 4.952583 8.802326 NMV_1675 2192637 CDS -1 1617515 1618579 1065 validated/Curated no putative ATPase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic ADENOSINETRIPHOSPHATASE-RXN$ATP-PYROPHOSPHATASE-RXN$ATPSYN-RXN$RXN0-1061$RXN0-4261 PWY-6126 2008-05-01 13:58:08 no 3 vladimir 0.356808 0.1296 0.205634 0.307981 0.335211 0.664789 0.352113 0.132394 0.287324 0.228169 0.419718 0.580282 0.357746 0.185915 0.143662 0.312676 0.329577 0.670423 0.360563 0.070423 0.185915 0.383099 0.256338 0.743662 0.439959 40329.035 -0.327966 0.234463 0.409605 0.240113 0.110169 0.50565 0.49435 0.30226 0.161017 0.141243 8.327721 8.271186 NMV_1676 2192638 CDS -2 1618756 1619748 993 validated/Curated no pheS phenylalanine-tRNA ligase alpha chain (phenylalanyl-tRNA synthetase alpha chain; PheRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.20 PHENYLALANINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:53:12 no Is composed of alpha and beta chains. Catalyses the attachment of phenylalanine to its cognate transfer RNA molecule in a highly specific two-step reaction. 1 vladimir 0.250755 0.2588 0.247734 0.242699 0.506546 0.493454 0.238671 0.229607 0.36858 0.163142 0.598187 0.401813 0.329305 0.199396 0.160121 0.311178 0.359517 0.640483 0.18429 0.347432 0.214502 0.253776 0.561934 0.438066 0.722708 37336.045 -0.29 0.239394 0.472727 0.209091 0.127273 0.548485 0.451515 0.281818 0.139394 0.142424 5.46154 9.863636 NMV_1677 2192639 CDS -2 1620094 1620453 360 validated/Curated no rplT 50S ribosomal protein L20 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 16:29:56 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.263889 0.2667 0.247222 0.222222 0.513889 0.486111 0.225 0.233333 0.366667 0.175 0.6 0.4 0.316667 0.208333 0.225 0.25 0.433333 0.566667 0.25 0.358333 0.15 0.241667 0.508333 0.491667 0.853063 13679.55 -0.542857 0.268908 0.420168 0.184874 0.10084 0.546218 0.453782 0.327731 0.268908 0.058824 11.63311 10.142857 NMV_1678 2192640 CDS -2 1620466 1620663 198 validated/Curated no rpmI 50S ribosomal protein L35 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 16:30:19 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.333333 0.2475 0.20202 0.217172 0.449495 0.550505 0.409091 0.19697 0.242424 0.151515 0.439394 0.560606 0.348485 0.242424 0.166667 0.242424 0.409091 0.590909 0.242424 0.30303 0.19697 0.257576 0.5 0.5 0.818528 7356.5 -0.824615 0.292308 0.461538 0.153846 0.076923 0.446154 0.553846 0.353846 0.323077 0.030769 11.772713 8.723077 NMV_1679 2192641 CDS -3 1620810 1621214 405 validated/Curated no infC translation initiation factor IF-3 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-24 16:30:40 no Is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. 1 vladimir 0.314103 0.2094 0.260684 0.215812 0.470085 0.529915 0.269231 0.230769 0.371795 0.128205 0.602564 0.397436 0.410256 0.160256 0.147436 0.282051 0.307692 0.692308 0.262821 0.237179 0.262821 0.237179 0.5 0.5 0.689524 17736.92 -0.679355 0.2 0.4 0.206452 0.058065 0.496774 0.503226 0.348387 0.2 0.148387 9.469109 9.729032 NMV_1680 2192642 CDS -1 1621349 1623262 1914 validated/Curated no thrS threonine-tRNA ligase (threonyl-tRNA synthetase; ThrRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.3 THREONINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:53:52 no Catalyses the attachment of threonine to its cognate transfer RNA molecule in a highly specific two-step reaction. 1 vladimir 0.264368 0.2179 0.26698 0.250784 0.484848 0.515152 0.227273 0.210031 0.376176 0.18652 0.586207 0.413793 0.363636 0.184953 0.172414 0.278997 0.357367 0.642633 0.202194 0.258621 0.252351 0.286834 0.510972 0.489028 0.734698 72769.15 -0.417582 0.232339 0.44741 0.215071 0.120879 0.546311 0.453689 0.302983 0.153846 0.149137 5.713615 10.050235 NMV_tRNA_41 2194856 tRNA -1 1623316 1623392 77 validated/Curated no Val tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:57:17 no tRNA Val anticodon GAC. vladimir NMV_1681 2192643 CDS +1 1623571 1624686 1116 validated/Curated no tgt queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase; guanine insertion enzyme) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.4.2.29 RXN0-1321 PWY-6700 2018-01-24 16:31:15 no Catalyses the following reaction: tRNA guanine + queuine <=> tRNA queuine + guanine. 2 vladimir 0.252688 0.2733 0.270609 0.203405 0.543907 0.456093 0.255376 0.247312 0.319892 0.177419 0.567204 0.432796 0.333333 0.185484 0.193548 0.287634 0.379032 0.620968 0.169355 0.387097 0.298387 0.145161 0.685484 0.314516 0.724495 42023.62 -0.399461 0.25876 0.444744 0.196765 0.132075 0.54717 0.45283 0.283019 0.161725 0.121294 7.36364 9.660377 NMV_1682 2192644 CDS +1 1624696 1625778 1083 validated/Curated no hemH ferrochelatase (protoheme ferro-lyase; heme synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 4.99.1.1 PROTOHEMEFERROCHELAT-RXN HEMESYN2-PWY$PWY0-1415 2018-01-24 16:31:34 no Catalyses the last step in heme biosynthesis, the chelation of a ferrous ion to proto-porphyrin IX, to form protoheme. 2 vladimir 0.244313 0.2987 0.25816 0.198813 0.556874 0.443126 0.207715 0.287834 0.329377 0.175074 0.617211 0.382789 0.311573 0.231454 0.181009 0.275964 0.412463 0.587537 0.21365 0.376855 0.264095 0.145401 0.64095 0.35905 0.623539 37990.235 -0.259226 0.267857 0.473214 0.217262 0.130952 0.580357 0.419643 0.25 0.136905 0.113095 6.828194 9.541667 NMV_1683 2192645 CDS +2 1625969 1626391 423 validated/Curated no putative cytochrome c552 3 : Putative function from multiple computational evidences c : carrier 9 : Periplasmic RXN0-5198 2018-01-31 14:31:58 no This monoheme basic protein appears to function as an electron donor to cytochrome oxidase in T.thermophilus. 2 vladimir 0.309693 0.3097 0.22695 0.153664 0.536643 0.463357 0.390071 0.148936 0.340426 0.120567 0.489362 0.510638 0.319149 0.241135 0.184397 0.255319 0.425532 0.574468 0.219858 0.539007 0.156028 0.085106 0.695035 0.304965 0.70242 14930.645 -0.219286 0.357143 0.585714 0.178571 0.071429 0.557143 0.442857 0.214286 0.15 0.064286 9.636375 9.514286 NMV_1684 2192646 CDS -1 1626434 1626673 240 validated/Curated partial truncated cell volume regulation protein A homolog (C-terminal 16% of the protein) 5 : Unknown function t : transporter 5 : Inner membrane protein 2018-01-24 16:32:02 no Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family, CvrA subfamily. CvrA Participates in control of cell volume in low-osmolarity conditions. 1 vladimir 0.178694 0.2096 0.350515 0.261168 0.560137 0.439863 0.185567 0.164948 0.463918 0.185567 0.628866 0.371134 0.268041 0.185567 0.247423 0.298969 0.43299 0.56701 0.082474 0.278351 0.340206 0.298969 0.618557 0.381443 0.602896 10289.215 -0.098958 0.34375 0.510417 0.197917 0.104167 0.604167 0.395833 0.28125 0.114583 0.166667 4.662697 9.572917 NMV_1685 2192647 CDS -2 1626961 1627188 228 validated/Curated partial truncated cell volume regulation protein A homolog (N-terminal 7% of the protein) 5 : Unknown function t : transporter 5 : Inner membrane protein 2018-01-24 16:32:20 no Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family, CvrA subfamily. CvrA Participates in control of cell volume in low-osmolarity conditions. 1 vladimir 0.149533 0.2336 0.34891 0.267913 0.582555 0.417445 0.196262 0.205607 0.35514 0.242991 0.560748 0.439252 0.130841 0.28972 0.224299 0.35514 0.514019 0.485981 0.121495 0.205607 0.46729 0.205607 0.672897 0.327103 0.599946 11256.835 0.649057 0.377358 0.54717 0.273585 0.09434 0.698113 0.301887 0.132075 0.075472 0.056604 9.107979 8.669811 NMV_1685.1 2662689 fCDS +1 1627393 1627746 354 validated/Curated pseudo conserved hypothetical integral membrane protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-06-18 16:29:25 vladimir NMV_1686 2192648 fCDS +2 1627733 1628119 387 validated/Curated pseudo conserved hypothetical integral membrane protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-06-18 16:29:39 no 2 vladimir 0.149871 0.2972 0.289406 0.263566 0.586563 0.413437 0.217054 0.263566 0.348837 0.170543 0.612403 0.387597 0.147287 0.193798 0.217054 0.44186 0.410853 0.589147 0.085271 0.434109 0.302326 0.178295 0.736434 0.263566 0.632889 13902.175 0.875 0.304688 0.492188 0.304688 0.125 0.734375 0.265625 0.140625 0.101562 0.039062 9.383018 9.539062 NMV_1687 2192649 CDS +1 1628152 1629726 1575 validated/Curated no lnt apolipoprotein N-acyltransferase (ALP N-acyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.10 : Lipoprotein ; 2.3.1.- 2018-01-22 19:21:06 no Transfers the acyl group to lipoproteins and is involved in lipoprotein biosynthesis. 2 vladimir 0.235218 0.3444 0.216374 0.204029 0.560754 0.439246 0.267057 0.265107 0.292398 0.175439 0.557505 0.442495 0.269006 0.265107 0.157895 0.307992 0.423002 0.576998 0.169591 0.502924 0.19883 0.128655 0.701754 0.298246 0.694262 57121.115 0.105078 0.302734 0.474609 0.230469 0.146484 0.632812 0.367188 0.167969 0.097656 0.070312 8.838921 9.09375 NMV_1688 2192650 CDS +3 1629990 1630853 864 validated/Curated no rpoH RNA polymerase sigma factor RpoH (Sigma-32) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-24 16:33:04 no Is an alternative sigma factors of the sigma70 family, which is required for the transcription of a specific subset of genes. 2 vladimir 0.26575 0.3013 0.254296 0.178694 0.555556 0.444444 0.250859 0.285223 0.350515 0.113402 0.635739 0.364261 0.343643 0.19244 0.185567 0.278351 0.378007 0.621993 0.202749 0.426117 0.226804 0.14433 0.652921 0.347079 0.656746 32799.945 -0.448276 0.255172 0.434483 0.22069 0.089655 0.506897 0.493103 0.293103 0.151724 0.141379 5.95565 9.582759 NMV_1689 2192651 CDS +3 1631337 1632221 885 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 13:54:18 no 2 vladimir 0.306215 0.2712 0.241808 0.180791 0.512994 0.487006 0.305085 0.244068 0.338983 0.111864 0.583051 0.416949 0.366102 0.152542 0.189831 0.291525 0.342373 0.657627 0.247458 0.416949 0.19661 0.138983 0.613559 0.386441 0.679152 33351.765 -0.482313 0.251701 0.397959 0.241497 0.068027 0.44898 0.55102 0.35034 0.183673 0.166667 6.119606 9.268707 NMV_1690 2192652 CDS -1 1632305 1632871 567 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-24 16:33:32 no Contains a RDD domain with three highly conserved amino acids, one arginine and two aspartates, hence the name of RDD domain. 1 vladimir 0.179337 0.2554 0.276803 0.288499 0.532164 0.467836 0.233918 0.233918 0.28655 0.245614 0.520468 0.479532 0.152047 0.251462 0.19883 0.397661 0.450292 0.549708 0.152047 0.280702 0.345029 0.222222 0.625731 0.374269 0.585063 18838.105 0.862941 0.305882 0.441176 0.3 0.147059 0.764706 0.235294 0.123529 0.1 0.023529 10.246162 8.7 NMV_1691 2192653 CDS -1 1632896 1633315 420 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 13:53:49 no 2 vladimir 0.264286 0.2905 0.242857 0.202381 0.533333 0.466667 0.292857 0.292857 0.278571 0.135714 0.571429 0.428571 0.3 0.207143 0.192857 0.3 0.4 0.6 0.2 0.371429 0.257143 0.171429 0.628571 0.371429 0.698731 15754.9 -0.248201 0.266187 0.410072 0.244604 0.079137 0.52518 0.47482 0.280576 0.201439 0.079137 10.593193 9.079137 NMV_1692 2192654 CDS -1 1633436 1634434 999 validated/Curated no holA DNA polymerase III delta subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:21:50 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 1 vladimir 0.221221 0.2633 0.325325 0.19019 0.588589 0.411411 0.198198 0.249249 0.423423 0.129129 0.672673 0.327327 0.288288 0.234234 0.177177 0.3003 0.411411 0.588589 0.177177 0.306306 0.375375 0.141141 0.681682 0.318318 0.585618 36278.545 0.030723 0.292169 0.478916 0.274096 0.072289 0.599398 0.400602 0.271084 0.138554 0.13253 6.208046 9.063253 NMV_1693 2192655 CDS -3 1634436 1634915 480 validated/Curated no putative lipooligosaccharide assembly protein LptE 3 : Putative function from multiple computational evidences m : membrane component 11 : Membrane 1.6.3 : Lipopolysaccharide ; 2020-02-19 15:35:43 no Together with LptD, is involved in the assembly of lipooligosaccharide (LOS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LOS recognition site at the outer membrane. 1 vladimir 0.225 0.2688 0.302083 0.204167 0.570833 0.429167 0.225 0.23125 0.39375 0.15 0.625 0.375 0.2875 0.25 0.16875 0.29375 0.41875 0.58125 0.1625 0.325 0.34375 0.16875 0.66875 0.33125 0.679074 17536.52 -0.050943 0.308176 0.477987 0.238994 0.081761 0.578616 0.421384 0.238994 0.119497 0.119497 5.746513 9.798742 NMV_1694 2192656 CDS -3 1634967 1635746 780 validated/Curated no polyphenol oxidase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.10.3.- CATECHOL-OXIDASE-RXN$MONOPHENOL-MONOOXYGENASE-RXN PWY-6481$PWY-6752 2018-01-23 13:30:12 no 16740638 Multicopper oxidase with polyphenol oxidase activity. 2 vladimir 0.205128 0.2987 0.301282 0.194872 0.6 0.4 0.234615 0.192308 0.446154 0.126923 0.638462 0.361538 0.242308 0.276923 0.207692 0.273077 0.484615 0.515385 0.138462 0.426923 0.25 0.184615 0.676923 0.323077 0.655437 27156.78 0.109266 0.378378 0.621622 0.212355 0.084942 0.629344 0.370656 0.19305 0.092664 0.100386 5.202095 9.965251 NMV_1695 2192657 CDS +3 1636305 1637252 948 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-24 16:35:00 no Related to the family of bile acid:sodium symporters. 2 vladimir 0.186709 0.2816 0.262658 0.268987 0.544304 0.455696 0.268987 0.183544 0.367089 0.18038 0.550633 0.449367 0.167722 0.281646 0.142405 0.408228 0.424051 0.575949 0.123418 0.379747 0.278481 0.218354 0.658228 0.341772 0.739089 32891.26 1.033016 0.352381 0.530159 0.320635 0.107937 0.742857 0.257143 0.11746 0.08254 0.034921 9.56823 7.911111 NMV_1696 2192658 CDS -1 1637405 1638475 1071 validated/Curated no rluD ribosomal large subunit pseudouridine synthase D (rRNA-uridine isomerase D; rRNA pseudouridylate synthase D) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.23 RXN-11837 2020-04-22 13:46:31 no Converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. 1 vladimir 0.247111 0.2667 0.271111 0.215111 0.537778 0.462222 0.226667 0.234667 0.389333 0.149333 0.624 0.376 0.336 0.221333 0.170667 0.272 0.392 0.608 0.178667 0.344 0.253333 0.224 0.597333 0.402667 0.678875 41439.095 -0.34385 0.264706 0.540107 0.235294 0.096257 0.529412 0.470588 0.28877 0.13369 0.15508 5.005028 9.68984 NMV_1697 2192659 CDS +3 1638528 1639331 804 validated/Curated no bamD comL outer-membrane protein assembly factor BamD (ComL) 2a : Function from experimental evidences in other organisms m : membrane component 8 : Outer membrane-associated 2018-01-30 16:29:27 no 8830266 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. 2 vladimir 0.267413 0.2898 0.242537 0.200249 0.532338 0.467662 0.231343 0.253731 0.324627 0.190299 0.578358 0.421642 0.373134 0.242537 0.156716 0.227612 0.399254 0.600746 0.197761 0.373134 0.246269 0.182836 0.619403 0.380597 0.704399 30807.71 -0.591011 0.269663 0.456929 0.17603 0.134831 0.516854 0.483146 0.277154 0.153558 0.123596 8.723991 9.734082 NMV_1698 2192660 CDS -3 1639389 1641671 2283 validated/Curated no comA competence protein ComA 1c : Function from experimental evidences in the studied genus ph : phenotype 5 : Inner membrane protein 2018-01-24 16:36:44 no 7934834 Essential for natural transformation. Could be a transporter involved in DNA translocation across the cytoplasmic membrane. 1 vladimir 0.147881 0.2250 0.373796 0.253372 0.598748 0.401252 0.144509 0.213873 0.398844 0.242775 0.612717 0.387283 0.193642 0.25578 0.245665 0.304913 0.501445 0.498555 0.105491 0.205202 0.476879 0.212428 0.682081 0.317919 0.58182 74372.71 0.261216 0.353111 0.547033 0.254703 0.12301 0.659913 0.340087 0.178003 0.109986 0.068017 9.49218 9.147612 NMV_1699 2192661 CDS +2 1642874 1647532 4659 validated/Curated no iga IgA-specific serine endopeptidase (IgA protease) 1c : Function from experimental evidences in the studied genus e : enzyme 10 : Secreted 3.4.21.72 3.4.21.72-RXN 2018-01-24 16:38:02 no 2105953, 3027577 Is an autotransporter that cleaves immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. 1 vladimir 0.332904 0.2297 0.221292 0.216141 0.450955 0.549045 0.293625 0.180296 0.353509 0.172569 0.533806 0.466194 0.394076 0.229878 0.169994 0.206053 0.399871 0.600129 0.311011 0.278815 0.140373 0.2698 0.419189 0.580811 0.626438 171397.125 -0.748325 0.311211 0.536727 0.168814 0.100515 0.462629 0.537371 0.257088 0.143041 0.114046 8.820869 9.548969 NMV_1700 2192662 CDS -1 1647710 1648912 1203 validated/Curated no trpB tryptophan synthase beta chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 4.2.1.20 RXN0-2382$TRYPSYN-RXN TRPSYN-PWY 2018-01-22 17:05:55 no The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate <=> L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. 1 vladimir 0.232751 0.2818 0.290108 0.195345 0.571904 0.428096 0.23192 0.194514 0.428928 0.144638 0.623441 0.376559 0.321696 0.214464 0.194514 0.269327 0.408978 0.591022 0.144638 0.436409 0.246883 0.17207 0.683292 0.316708 0.750871 43204.245 -0.2205 0.3075 0.5375 0.2125 0.11 0.5875 0.4125 0.2675 0.145 0.1225 6.104225 9.7725 NMV_1701 2192663 CDS -3 1649097 1649786 690 validated/Curated no putative DNA glycosylase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-01 13:51:21 no 1 vladimir 0.223188 0.2188 0.302899 0.255072 0.521739 0.478261 0.23913 0.191304 0.343478 0.226087 0.534783 0.465217 0.273913 0.265217 0.156522 0.304348 0.421739 0.578261 0.156522 0.2 0.408696 0.234783 0.608696 0.391304 0.606967 25348.67 -0.026638 0.296943 0.49345 0.20524 0.113537 0.60262 0.39738 0.253275 0.148472 0.104803 8.875343 9.432314 NMV_1702 2192664 CDS +1 1649983 1650762 780 validated/Curated no rsmA ksgA ribosomal RNA small subunit methyltransferase A (16S rRNA dimethylase; high level kasugamycin resistance protein KsgA; kasugamycin dimethyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.182 RXN-11633 2018-01-22 19:00:53 no Introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. Strains lacking the methylase are resistant to kasugamycin. 1 vladimir 0.252564 0.2551 0.278205 0.214103 0.533333 0.466667 0.257692 0.238462 0.384615 0.119231 0.623077 0.376923 0.357692 0.176923 0.123077 0.342308 0.3 0.7 0.142308 0.35 0.326923 0.180769 0.676923 0.323077 0.714785 29244.77 -0.174517 0.185328 0.474903 0.262548 0.100386 0.559846 0.440154 0.320463 0.173745 0.146718 6.78109 9.274131 NMV_1703 2192665 CDS +2 1650914 1651663 750 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2020-04-20 20:29:30 no ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. 2 vladimir 0.286694 0.2689 0.260631 0.183813 0.529492 0.470508 0.279835 0.209877 0.386831 0.123457 0.596708 0.403292 0.349794 0.17284 0.144033 0.333333 0.316872 0.683128 0.230453 0.423868 0.251029 0.09465 0.674897 0.325103 0.726363 27010.105 -0.229339 0.231405 0.466942 0.235537 0.090909 0.533058 0.466942 0.293388 0.152893 0.140496 5.942833 9.524793 NMV_1704 2192666 CDS +2 1651736 1652095 360 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 13:50:31 no 2 vladimir 0.241667 0.2472 0.266667 0.244444 0.513889 0.486111 0.233333 0.191667 0.375 0.2 0.566667 0.433333 0.375 0.158333 0.108333 0.358333 0.266667 0.733333 0.116667 0.391667 0.316667 0.175 0.708333 0.291667 0.695215 14227.67 -0.222689 0.151261 0.428571 0.218487 0.151261 0.546218 0.453782 0.310924 0.092437 0.218487 4.10685 10.008403 NMV_1705 2192667 CDS +3 1652100 1652540 441 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 13:50:10 no 2 vladimir 0.256236 0.2948 0.251701 0.197279 0.546485 0.453515 0.312925 0.210884 0.278912 0.197279 0.489796 0.510204 0.217687 0.306122 0.204082 0.272109 0.510204 0.489796 0.238095 0.367347 0.272109 0.122449 0.639456 0.360544 0.521776 16309.315 0.012329 0.369863 0.506849 0.219178 0.116438 0.554795 0.445205 0.205479 0.136986 0.068493 9.739983 9.054795 NMV_1706 2192668 CDS +1 1652572 1653846 1275 validated/Curated no folC FolC bifunctional protein [includes: folylpolyglutamate synthase (folylpoly-gamma-glutamate synthetase; FPGS; tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase) and dihydrofolate synthase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 6.3.2.17, 6.3.2.12 DIHYDROFOLATESYNTH-RXN$FOLYLPOLYGLUTAMATESYNTH-RXN$FORMYLTHFGLUSYNTH-RXN$RXN0-2921 1CMET2-PWY$PWY-2161$PWY-6614 2018-01-30 13:41:00 no Is responsible for the addition of a polyglutamate tail to folate and folate derivatives. It is an ATP-dependent enzyme that plays a key role in the retention of the intracellular folate pool. 2 vladimir 0.23451 0.2918 0.271373 0.202353 0.563137 0.436863 0.218824 0.225882 0.383529 0.171765 0.609412 0.390588 0.291765 0.228235 0.174118 0.305882 0.402353 0.597647 0.192941 0.421176 0.256471 0.129412 0.677647 0.322353 0.697052 46522.365 -0.049292 0.292453 0.521226 0.240566 0.101415 0.573113 0.426887 0.247642 0.129717 0.117925 5.977119 9.525943 NMV_1707 2192669 CDS +1 1653859 1654857 999 validated/Curated no putative cell division protein FtsN (tetrapac protein) 3 : Putative function from multiple computational evidences f : factor 5 : Inner membrane protein 5.1 : Cell division ; 2020-04-22 16:43:20 no 8730876 FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. 2 vladimir 0.357357 0.2883 0.246246 0.108108 0.534535 0.465465 0.342342 0.168168 0.417417 0.072072 0.585586 0.414414 0.408408 0.321321 0.135135 0.135135 0.456456 0.543544 0.321321 0.375375 0.186186 0.117117 0.561562 0.438438 0.756477 35519.415 -1.00512 0.370482 0.551205 0.126506 0.018072 0.409639 0.590361 0.364458 0.207831 0.156627 9.467613 9.01506 NMV_1708 2192670 CDS +2 1654850 1655347 498 validated/Curated no putative colicin V production protein (DedE protein) 3 : Putative function from multiple computational evidences m : membrane component 5 : Inner membrane protein 2008-05-01 13:49:09 no 2 vladimir 0.168675 0.3052 0.253012 0.273092 0.558233 0.441767 0.198795 0.198795 0.373494 0.228916 0.572289 0.427711 0.150602 0.307229 0.13253 0.409639 0.439759 0.560241 0.156627 0.409639 0.253012 0.180723 0.662651 0.337349 0.646459 17454.94 0.986061 0.357576 0.533333 0.30303 0.109091 0.70303 0.29697 0.133333 0.060606 0.072727 4.96508 8.151515 NMV_1709 2192671 CDS +2 1655660 1657204 1545 validated/Curated no purF amidophosphoribosyltransferase (glutamine phosphoribosylpyrophosphate amidotransferase; ATASE; GPATase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 2.4.2.14 PRPPAMIDOTRANS-RXN PWY-6121 2018-01-24 16:41:03 no Catalyses the following reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. It is the rate-limiting enzyme in the de novo pathway of purine ribonucleotide synthesis. 1 vladimir 0.22589 0.3061 0.274434 0.193528 0.580582 0.419417 0.24466 0.205825 0.396116 0.153398 0.601942 0.398058 0.295146 0.217476 0.205825 0.281553 0.423301 0.576699 0.137864 0.495146 0.221359 0.145631 0.716505 0.283495 0.738629 56105.385 -0.204086 0.309339 0.538911 0.217899 0.097276 0.560311 0.439689 0.262646 0.136187 0.126459 5.917412 9.854086 NMV_1710 2192672 CDS +2 1657304 1657795 492 validated/Curated no greB transcription elongation factor GreB (transcript cleavage factor GreB) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2020-04-22 13:05:26 no Is necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. Arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked DNA/RNA/polymerase ternary complexes. Cleavage of the nascent transcript by cleavage factors, such as GreA, allows the resumption of elongation from the new 3' terminus. 1 vladimir 0.27439 0.2663 0.270325 0.189024 0.536585 0.463415 0.27439 0.207317 0.390244 0.128049 0.597561 0.402439 0.341463 0.170732 0.207317 0.280488 0.378049 0.621951 0.207317 0.420732 0.213415 0.158537 0.634146 0.365854 0.729641 18706.58 -0.490798 0.226994 0.447853 0.251534 0.067485 0.503067 0.496933 0.331288 0.153374 0.177914 5.127007 10.214724 NMV_1711 2192673 CDS +3 1657854 1658480 627 validated/Curated no trpF N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.5.1.15 : Tryptophan ; 5.3.1.24 PRAISOM-RXN TRPSYN-PWY 2018-01-24 16:41:54 no Catalyses the fourth step in the biosynthesis of tryptophan: N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. 2 vladimir 0.229665 0.3365 0.259968 0.173844 0.596491 0.403509 0.22488 0.210526 0.425837 0.138756 0.636364 0.363636 0.263158 0.291866 0.181818 0.263158 0.473684 0.526316 0.200957 0.507177 0.172249 0.119617 0.679426 0.320574 0.719131 22250.475 0.002404 0.355769 0.572115 0.206731 0.105769 0.596154 0.403846 0.245192 0.139423 0.105769 8.468712 9.346154 NMV_1712 2192674 CDS -1 1659833 1660807 975 validated/Curated no era GTPase Era 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; 2020-04-22 13:19:31 no An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis. 1 vladimir 0.252165 0.2327 0.295455 0.219697 0.528139 0.471861 0.266234 0.178571 0.402597 0.152597 0.581169 0.418831 0.331169 0.188312 0.152597 0.327922 0.340909 0.659091 0.159091 0.331169 0.331169 0.178571 0.662338 0.337662 0.66284 34587.61 -0.146254 0.241042 0.472313 0.250814 0.09772 0.550489 0.449511 0.302932 0.156352 0.14658 6.547279 9.534202 NMV_1713 2192675 CDS -2 1660804 1661523 720 validated/Curated no rnc ribonuclease III (RNase III) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.26.3 3.1.26.3-RXN 2018-01-24 17:15:37 no Cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. 1 vladimir 0.229167 0.2181 0.341667 0.211111 0.559722 0.440278 0.233333 0.195833 0.391667 0.179167 0.5875 0.4125 0.3375 0.204167 0.183333 0.275 0.3875 0.6125 0.116667 0.254167 0.45 0.179167 0.704167 0.295833 0.578976 26851.78 -0.381172 0.284519 0.439331 0.188285 0.108787 0.531381 0.468619 0.32636 0.188285 0.138075 9.242134 9.48954 NMV_1714 2192676 CDS +2 1661690 1662013 324 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 13:47:37 no 2 vladimir 0.256173 0.3580 0.225309 0.160494 0.583333 0.416667 0.231481 0.203704 0.398148 0.166667 0.601852 0.398148 0.324074 0.277778 0.175926 0.222222 0.453704 0.546296 0.212963 0.592593 0.101852 0.092593 0.694444 0.305556 0.756269 11824.4 -0.471963 0.327103 0.598131 0.149533 0.11215 0.504673 0.495327 0.233645 0.056075 0.17757 3.898994 9.588785 NMV_1715 2192677 CDS +3 1662060 1662536 477 validated/Curated no ribH 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase; lumazine synthase; riboflavin synthase beta chain) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 2.5.1.78 LUMAZINESYN-RXN RIBOSYN2-PWY 2018-01-24 17:16:49 no Is involved in riboflavin biosynthesis, by catalysing the following reaction: 1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H(2)O + phosphate. 2 vladimir 0.268344 0.3208 0.234801 0.176101 0.555556 0.444444 0.27044 0.194969 0.433962 0.100629 0.628931 0.371069 0.320755 0.232704 0.125786 0.320755 0.358491 0.641509 0.213836 0.534591 0.144654 0.106918 0.679245 0.320755 0.716174 17038.685 0.144304 0.297468 0.525316 0.278481 0.050633 0.563291 0.436709 0.246835 0.082278 0.164557 4.351128 9.822785 NMV_1716 2192678 CDS +2 1662614 1663039 426 validated/Curated no nusB transcription antitermination protein NusB (N utilization substance protein B; NusB protein) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-24 17:17:37 no Is involved in the regulation of rRNA biosynthesis by transcriptional antitermination. 2 vladimir 0.269953 0.3662 0.20892 0.15493 0.575117 0.424883 0.28169 0.267606 0.338028 0.112676 0.605634 0.394366 0.338028 0.260563 0.133803 0.267606 0.394366 0.605634 0.190141 0.570423 0.15493 0.084507 0.725352 0.274648 0.697436 16010.75 -0.486525 0.248227 0.453901 0.205674 0.078014 0.503546 0.496454 0.312057 0.163121 0.148936 6.955727 9.914894 NMNmiscRNA0170 54919403 misc_RNA +1 1663233 1663391 159 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:04:51 28334889 Function unknown. vladimir NMV_1717 2192679 CDS -1 1663406 1664440 1035 validated/Curated no pyrC dihydroorotase (DHOase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; 3.5.2.3 DIHYDROOROT-RXN PWY-5686 2018-01-24 17:17:57 no Catalyses the third step in the de novo biosynthesis of pyrimidine: (S)-dihydroorotate + H(2)O <=> N-carbamoyl-L-aspartate. 2 vladimir 0.22029 0.3411 0.257005 0.181643 0.598068 0.401932 0.231884 0.24058 0.411594 0.115942 0.652174 0.347826 0.275362 0.278261 0.13913 0.307246 0.417391 0.582609 0.153623 0.504348 0.22029 0.121739 0.724638 0.275362 0.70842 37152.505 0.089826 0.30814 0.534884 0.235465 0.09593 0.610465 0.389535 0.241279 0.125 0.116279 5.833992 9.546512 NMV_1718 2192680 CDS -2 1664803 1665027 225 validated/Curated no putative sulfur carrier protein TusA 3 : Putative function from multiple computational evidences c : carrier 2 : Cytoplasmic 1.8.2 : Sulfur metabolism ; 2018-01-31 12:59:09 no 24648525 TusA is a sulfur carrier protein involved in sulfur trafficking for oxidative dissimilatory sulfur metabolism. 1 vladimir 0.231111 0.2444 0.306667 0.217778 0.551111 0.448889 0.213333 0.213333 0.4 0.173333 0.613333 0.386667 0.306667 0.226667 0.16 0.306667 0.386667 0.613333 0.173333 0.293333 0.36 0.173333 0.653333 0.346667 0.668555 7895.765 0.012162 0.324324 0.554054 0.243243 0.067568 0.567568 0.432432 0.243243 0.121622 0.121622 5.475746 9.027027 NMV_1719 2192681 CDS +1 1665136 1665759 624 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2018-01-24 17:18:50 no Also known as Cnp1 (cryptic neisserial protein 1), detected in pathogenic Neisseria species but not in commensal species. 2 vladimir 0.262821 0.3478 0.230769 0.158654 0.578526 0.421474 0.288462 0.259615 0.302885 0.149038 0.5625 0.4375 0.302885 0.269231 0.206731 0.221154 0.475962 0.524038 0.197115 0.514423 0.182692 0.105769 0.697115 0.302885 0.639249 23237.52 -0.568116 0.309179 0.521739 0.173913 0.10628 0.521739 0.478261 0.2657 0.154589 0.111111 9.174202 9.84058 NMV_1720 2192682 CDS -2 1665796 1666668 873 validated/Curated no accD acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; 6.4.1.2 ACETYL-COA-CARBOXYLTRANSFER-RXN$RXN0-5055 PWY-4381$PWY0-1264 2018-01-24 17:19:22 no Catalyses the first step in the synthesis of long-chain fatty acids: ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA. 1 vladimir 0.223368 0.2360 0.298969 0.241695 0.534937 0.465063 0.24055 0.216495 0.360825 0.182131 0.57732 0.42268 0.278351 0.223368 0.202749 0.295533 0.426117 0.573883 0.151203 0.268041 0.333333 0.247423 0.601375 0.398625 0.666099 31737.345 -0.205517 0.293103 0.534483 0.224138 0.068966 0.551724 0.448276 0.262069 0.148276 0.113793 8.9515 9.448276 NMV_1721 2192683 CDS -2 1666705 1667490 786 validated/Curated no trpA tryptophan synthase alpha chain 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.15 : Tryptophan ; 4.2.1.20 RXN0-2381$TRYPSYN-RXN TRPSYN-PWY 2018-01-22 17:06:02 no The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate <=> L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. 1 vladimir 0.216285 0.2150 0.326972 0.24173 0.541985 0.458015 0.259542 0.148855 0.450382 0.141221 0.599237 0.400763 0.274809 0.232824 0.179389 0.312977 0.412214 0.587786 0.114504 0.263359 0.351145 0.270992 0.614504 0.385496 0.601459 27968.93 0.083142 0.306513 0.559387 0.264368 0.068966 0.601533 0.398467 0.256705 0.118774 0.137931 5.025642 9.616858 NMV_tRNA_40 2194855 tRNA -1 1667917 1668009 93 validated/Curated no Ser tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:01:27 no tRNA Ser anticodon GCT. vladimir NMV_1722 2192684 CDS -2 1668166 1668330 165 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:59:17 no 1 vladimir 0.30303 0.2545 0.248485 0.193939 0.50303 0.49697 0.163636 0.272727 0.381818 0.181818 0.654545 0.345455 0.436364 0.290909 0.054545 0.218182 0.345455 0.654545 0.309091 0.2 0.309091 0.181818 0.509091 0.490909 0.659686 6132.575 -0.611111 0.259259 0.425926 0.166667 0.111111 0.481481 0.518519 0.296296 0.111111 0.185185 4.489662 8.925926 NMV_1723 2192685 CDS -3 1668384 1668785 402 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:59:01 no 2 vladimir 0.268657 0.2637 0.238806 0.228856 0.502488 0.497512 0.276119 0.238806 0.30597 0.179104 0.544776 0.455224 0.320896 0.201493 0.186567 0.291045 0.38806 0.61194 0.208955 0.350746 0.223881 0.216418 0.574627 0.425373 0.573442 15046.56 -0.223308 0.263158 0.473684 0.233083 0.097744 0.541353 0.458647 0.218045 0.097744 0.120301 4.925453 9.721805 NMV_1724 2192686 CDS -2 1668808 1669569 762 validated/Curated no kdsB 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase; CMP-2-keto-3-deoxyoctulosonic acid synthetase; CKS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.7.7.38 CPM-KDOSYNTH-RXN KDO-NAGLIPASYN-PWY$PWY-1269 2018-01-24 17:20:10 no Activates KDO, a 8-carbon sugar required for incorporation into bacterial lipooligosaccharide: CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate. 2 vladimir 0.224409 0.3136 0.275591 0.186352 0.589239 0.410761 0.212598 0.259843 0.42126 0.106299 0.681102 0.318898 0.295276 0.275591 0.133858 0.295276 0.409449 0.590551 0.165354 0.405512 0.271654 0.15748 0.677165 0.322835 0.73107 27822.82 -0.110277 0.272727 0.537549 0.245059 0.083004 0.565217 0.434783 0.272727 0.142292 0.130435 5.865822 10.114625 NMV_1725 2192687 CDS -3 1669566 1669748 183 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2020-04-23 19:06:30 no Belongs to the Trm112 family of proteins, which are not functionally characterised. Trm112 is required for tRNA methylation in Saccharomyces cerevisiae and is found in complexes with 2 tRNA methylases and with other putative methyltransferases. 2 vladimir 0.327869 0.2240 0.256831 0.191257 0.480874 0.519126 0.278689 0.229508 0.327869 0.163934 0.557377 0.442623 0.42623 0.147541 0.163934 0.262295 0.311475 0.688525 0.278689 0.295082 0.278689 0.147541 0.57377 0.42623 0.604569 7064.935 -0.646667 0.183333 0.333333 0.216667 0.1 0.516667 0.483333 0.366667 0.183333 0.183333 5.789879 9.566667 NMV_1726 2192688 CDS -1 1669817 1670392 576 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2015-11-19 17:51:57 no 1 vladimir 0.285714 0.2228 0.258503 0.232993 0.481293 0.518707 0.295918 0.178571 0.331633 0.193878 0.510204 0.489796 0.341837 0.255102 0.147959 0.255102 0.403061 0.596939 0.219388 0.234694 0.295918 0.25 0.530612 0.469388 0.613195 21654.15 -0.38359 0.287179 0.482051 0.194872 0.087179 0.538462 0.461538 0.276923 0.169231 0.107692 9.515358 9.251282 NMV_1727 2192689 CDS -3 1670604 1671638 1035 validated/Curated no lpxK tetraacyldisaccharide 4'-kinase (lipid A 4'-kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 2.7.1.130 TETRAACYLDISACC4KIN-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2018-01-24 17:20:57 no Is involved in the synthesis of lipid A portion of the bacterial LOS. It phosphorylates the 4'-position of a tetraacyldisaccharide 1-phosphate precursor (DS-1-P) of lipid A. 1 vladimir 0.209662 0.2435 0.315942 0.230918 0.55942 0.44058 0.226087 0.208696 0.408696 0.156522 0.617391 0.382609 0.257971 0.255072 0.17971 0.307246 0.434783 0.565217 0.144928 0.266667 0.35942 0.228986 0.626087 0.373913 0.602674 36983.125 0.024419 0.299419 0.56686 0.258721 0.078488 0.587209 0.412791 0.264535 0.148256 0.116279 8.678383 9.040698 NMV_1729 2192691 CDS -1 1672031 1673311 1281 validated/Curated no maeB NADP-dependent malic enzyme 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.8 : Gluconeogenesis ; 1.1.1.40 MALIC-NADP-RXN GLUCONEO-PWY 2018-01-24 17:24:32 no Catalyses the following reactions: (S)-malate + NADP(+) <=> pyruvate + CO(2) + NADPH and oxaloacetate <=> pyruvate + CO(2). 2 vladimir 0.246682 0.2873 0.262295 0.203747 0.549571 0.450429 0.252927 0.163934 0.41452 0.168618 0.578454 0.421546 0.306792 0.264637 0.133489 0.295082 0.398126 0.601874 0.180328 0.433255 0.238876 0.147541 0.672131 0.327869 0.828307 46011.225 -0.001643 0.302817 0.535211 0.2277 0.079812 0.600939 0.399061 0.258216 0.119718 0.138498 5.083641 9.471831 NMV_1730 2192692 CDS -2 1673533 1674153 621 validated/Curated no tmk thymidylate kinase (dTMP kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.7.4.9 DTMPKI-RXN P1-PWY$PWY0-166 2018-01-24 17:24:57 no Catalyses the following reaction: ATP + dTMP <=> ADP + dTDP. 2 vladimir 0.225443 0.2593 0.302738 0.21256 0.561997 0.438003 0.231884 0.227053 0.381643 0.15942 0.608696 0.391304 0.275362 0.202899 0.21256 0.309179 0.415459 0.584541 0.169082 0.347826 0.31401 0.169082 0.661836 0.338164 0.617576 23015.475 -0.199029 0.271845 0.475728 0.228155 0.092233 0.563107 0.436893 0.286408 0.135922 0.150485 5.192589 9.912621 NMV_1731 2192693 CDS -3 1674213 1675208 996 validated/Curated no putative endolytic murein transglycosylase 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 4.2.2.- 2018-02-01 18:05:22 no Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. 1 vladimir 0.247992 0.2661 0.277108 0.208835 0.543173 0.456827 0.286145 0.201807 0.346386 0.165663 0.548193 0.451807 0.313253 0.237952 0.186747 0.262048 0.424699 0.575301 0.144578 0.358434 0.298193 0.198795 0.656626 0.343373 0.667629 36987.91 -0.384592 0.293051 0.492447 0.199396 0.120846 0.546828 0.453172 0.280967 0.172205 0.108761 9.548576 9.413897 NMV_1732 2192694 CDS +3 1675293 1675865 573 validated/Curated no ampD 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.5.1.28 3.5.1.28-RXN$RXN0-5225 2018-02-01 18:05:44 no Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety. 2 vladimir 0.22164 0.2984 0.268761 0.211169 0.56719 0.43281 0.198953 0.251309 0.335079 0.21466 0.586387 0.413613 0.287958 0.235602 0.209424 0.267016 0.445026 0.554974 0.17801 0.408377 0.26178 0.151832 0.670157 0.329843 0.606351 21473.405 -0.403684 0.273684 0.515789 0.184211 0.152632 0.542105 0.457895 0.284211 0.152632 0.131579 6.060539 9.684211 NMV_1733 2192695 CDS +1 1676059 1677345 1287 validated/Curated no putative cell division protein ZipA 3 : Putative function from multiple computational evidences f : factor 5 : Inner membrane protein 5.1 : Cell division ; 2020-02-22 15:56:58 no ZIpA is an essential cell division protein that stabilises the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. 2 vladimir 0.243978 0.3279 0.236208 0.191919 0.564103 0.435897 0.244755 0.249417 0.340326 0.165501 0.589744 0.410256 0.314685 0.268065 0.123543 0.293706 0.391608 0.608392 0.172494 0.4662 0.244755 0.11655 0.710956 0.289044 0.739406 47129.035 -0.166589 0.287383 0.518692 0.219626 0.100467 0.546729 0.453271 0.235981 0.121495 0.114486 5.84446 9.03972 NMV_1734 2192696 CDS +1 1677493 1680018 2526 validated/Curated no ligA DNA ligase (polydeoxyribonucleotide synthase [NAD+]) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1 : DNA related ; 2.1.1 : DNA replication ; 6.5.1.2 DNA-LIGASE-NAD+-RXN 2020-02-21 17:08:19 no Is the enzyme that joins two DNA fragments by catalysing the formation of an internucleotide ester bond between phosphate and deoxyribose. It is active during DNA replication, DNA repair and DNA recombination. 2 vladimir 0.254157 0.3357 0.245051 0.165083 0.58076 0.41924 0.212589 0.275534 0.390736 0.12114 0.666271 0.333729 0.319477 0.251781 0.165083 0.263658 0.416865 0.583135 0.230404 0.47981 0.179335 0.110451 0.659145 0.340855 0.699887 92426.99 -0.348989 0.290131 0.508918 0.206897 0.091558 0.539834 0.460166 0.267539 0.134364 0.133175 5.621437 9.617122 NMV_1735 2192697 CDS +3 1680075 1681250 1176 validated/Curated no putative heme chaperone HemW 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 2020-02-25 14:09:05 no Probably acts as a heme chaperone. Binds one molecule of heme per monomer, possibly covalently. Heme binding is not affected by either [4Fe-4S] or S-adenosyl-L-methionine (SAM)-binding. Does not have coproporphyrinogen III dehydrogenase activity in vitro. 2 vladimir 0.238095 0.3036 0.255952 0.202381 0.559524 0.440476 0.247449 0.25 0.32398 0.178571 0.57398 0.42602 0.293367 0.257653 0.163265 0.285714 0.420918 0.579082 0.173469 0.403061 0.280612 0.142857 0.683673 0.316327 0.665916 43353.95 -0.184143 0.29156 0.488491 0.212276 0.112532 0.570332 0.429668 0.237852 0.120205 0.117647 5.567284 9.547315 NMV_1737 2192699 CDS +2 1681835 1682359 525 validated/Curated no nspA outer-membrane associated protein NspA 1b : Function from experimental evidences in the studied species ph : phenotype 8 : Outer membrane-associated 2018-01-24 17:32:03 no 12716881, 9104804 2 vladimir 0.219048 0.3562 0.230476 0.194286 0.586667 0.413333 0.228571 0.171429 0.388571 0.211429 0.56 0.44 0.262857 0.291429 0.194286 0.251429 0.485714 0.514286 0.165714 0.605714 0.108571 0.12 0.714286 0.285714 0.762357 18352.015 -0.006897 0.396552 0.609195 0.206897 0.114943 0.597701 0.402299 0.189655 0.12069 0.068966 9.638191 8.672414 NMV_1738 2192700 CDS +2 1682495 1682884 390 validated/Curated no putative endoribonuclease 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 2018-01-24 17:32:24 no Contains a domain found in endoribonucleases, that are active on single-stranded mRNA and inhibit protein synthesis by cleavage of mRNA. 2 vladimir 0.212821 0.3692 0.25641 0.161538 0.625641 0.374359 0.223077 0.184615 0.484615 0.107692 0.669231 0.330769 0.261538 0.307692 0.123077 0.307692 0.430769 0.569231 0.153846 0.615385 0.161538 0.069231 0.776923 0.223077 0.77509 13407.75 0.33876 0.356589 0.612403 0.232558 0.077519 0.651163 0.348837 0.170543 0.069767 0.100775 4.640587 9.72093 NMV_1739 2192701 CDS +1 1682962 1683792 831 validated/Curated no apaH bis(5'-nucleosyl)-tetraphosphatase, symmetrical (diadenosine tetraphosphatase; Ap4A hydrolase; diadenosine 5',5'''- P1,P4-tetraphosphate pyrophosphohydrolase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.33 : Nucleotide and nucleoside conversions ; 3.6.1.41 3.6.1.41-RXN 2018-01-24 17:33:51 no Catalyses the following reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O <=> 2 ADP. 2 vladimir 0.261131 0.3285 0.253911 0.156438 0.582431 0.417569 0.263538 0.256318 0.33574 0.144404 0.592058 0.407942 0.314079 0.205776 0.202166 0.277978 0.407942 0.592058 0.205776 0.523466 0.223827 0.046931 0.747292 0.252708 0.702658 31041.415 -0.290942 0.282609 0.463768 0.213768 0.126812 0.561594 0.438406 0.271739 0.155797 0.115942 8.659477 9.271739 NMV_1740 2192702 CDS +3 1683807 1685264 1458 validated/Curated no putative Trk system potassium uptake protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-24 17:34:49 no Is involved in active sodium uptake, utilising ATP in the process. 2 vladimir 0.179698 0.3525 0.238683 0.229081 0.591221 0.408779 0.279835 0.216049 0.304527 0.199588 0.520576 0.479424 0.17284 0.269547 0.168724 0.388889 0.438272 0.561728 0.08642 0.572016 0.242798 0.098765 0.814815 0.185185 0.67216 53150.02 0.71732 0.346392 0.490722 0.261856 0.154639 0.690722 0.309278 0.136082 0.08866 0.047423 9.325447 8.769072 NMV_1741 2192703 CDS -2 1685305 1685694 390 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:54:47 no 3 vladimir 0.320513 0.1154 0.189744 0.374359 0.305128 0.694872 0.307692 0.115385 0.307692 0.269231 0.423077 0.576923 0.361538 0.146154 0.115385 0.376923 0.261538 0.738462 0.292308 0.084615 0.146154 0.476923 0.230769 0.769231 0.500311 15025.89 0.162016 0.170543 0.418605 0.286822 0.162791 0.620155 0.379845 0.255814 0.100775 0.155039 4.4981 8.744186 NMV_1742 2192704 CDS -1 1685876 1686277 402 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:54:57 no 25569427 3 vladimir 0.393035 0.1020 0.149254 0.355721 0.251244 0.748756 0.358209 0.067164 0.268657 0.30597 0.335821 0.664179 0.462687 0.119403 0.089552 0.328358 0.208955 0.791045 0.358209 0.119403 0.089552 0.432836 0.208955 0.791045 0.563016 16257.7 -0.454135 0.142857 0.390977 0.210526 0.210526 0.473684 0.526316 0.315789 0.12782 0.18797 4.605553 8.857143 NMV_1743 2192705 CDS -2 1686583 1686960 378 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:26:20 no 25569427 3 vladimir 0.333333 0.1243 0.224868 0.31746 0.349206 0.650794 0.34127 0.111111 0.309524 0.238095 0.420635 0.579365 0.412698 0.111111 0.15873 0.31746 0.269841 0.730159 0.246032 0.150794 0.206349 0.396825 0.357143 0.642857 0.504753 15344.96 -0.4904 0.12 0.392 0.224 0.192 0.552 0.448 0.336 0.136 0.2 4.589531 10.024 NMV_1744 2192706 CDS -2 1686991 1687389 399 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:25:36 no 25569427 3 vladimir 0.330827 0.1128 0.223058 0.333333 0.33584 0.66416 0.338346 0.112782 0.285714 0.263158 0.398496 0.601504 0.383459 0.097744 0.195489 0.323308 0.293233 0.706767 0.270677 0.12782 0.18797 0.413534 0.315789 0.684211 0.533013 16384.325 -0.514394 0.113636 0.348485 0.212121 0.19697 0.55303 0.44697 0.348485 0.166667 0.181818 5.29203 9.863636 NMV_1745 2192707 CDS -3 1687395 1688072 678 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 17:35:45 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 1 vladimir 0.364307 0.2212 0.216814 0.19764 0.438053 0.561947 0.349558 0.163717 0.327434 0.159292 0.49115 0.50885 0.411504 0.238938 0.172566 0.176991 0.411504 0.588496 0.331858 0.261062 0.150442 0.256637 0.411504 0.588496 0.550862 25166 -0.904889 0.315556 0.528889 0.16 0.111111 0.44 0.56 0.297778 0.182222 0.115556 9.457146 9.084444 NMV_1746 2192708 CDS -1 1688207 1688749 543 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:53:51 no 3 vladimir 0.3186 0.1584 0.189687 0.333333 0.348066 0.651934 0.320442 0.154696 0.254144 0.270718 0.40884 0.59116 0.38674 0.154696 0.127072 0.331492 0.281768 0.718232 0.248619 0.165746 0.187845 0.39779 0.353591 0.646409 0.556762 21079.405 -0.211111 0.194444 0.422222 0.25 0.166667 0.538889 0.461111 0.25 0.133333 0.116667 6.480095 8.8 NMV_1747 2192709 CDS -1 1688876 1689103 228 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:53:40 no 1 vladimir 0.368421 0.1360 0.20614 0.289474 0.342105 0.657895 0.328947 0.105263 0.302632 0.263158 0.407895 0.592105 0.421053 0.105263 0.118421 0.355263 0.223684 0.776316 0.355263 0.197368 0.197368 0.25 0.394737 0.605263 0.464554 8753.52 -0.201333 0.173333 0.413333 0.28 0.146667 0.506667 0.493333 0.28 0.093333 0.186667 4.268456 8.093333 NMV_1748 2192710 CDS -3 1689162 1689485 324 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:53:27 no 3 vladimir 0.354938 0.1451 0.175926 0.324074 0.320988 0.679012 0.324074 0.157407 0.259259 0.259259 0.416667 0.583333 0.388889 0.157407 0.138889 0.314815 0.296296 0.703704 0.351852 0.12037 0.12963 0.398148 0.25 0.75 0.529883 12211.3 -0.185981 0.261682 0.420561 0.224299 0.121495 0.514019 0.485981 0.196262 0.056075 0.140187 4.158974 9.009346 NMV_1749 2192711 CDS -2 1689475 1689828 354 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:21:07 no 25569427 3 vladimir 0.324859 0.1780 0.189266 0.30791 0.367232 0.632768 0.313559 0.177966 0.254237 0.254237 0.432203 0.567797 0.381356 0.152542 0.161017 0.305085 0.313559 0.686441 0.279661 0.20339 0.152542 0.364407 0.355932 0.644068 0.550507 13747.17 -0.347863 0.17094 0.418803 0.239316 0.179487 0.581197 0.418803 0.239316 0.119658 0.119658 5.536415 9.42735 NMV_1750 2192712 CDS -1 1689812 1690510 699 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 17:36:22 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 1 vladimir 0.369099 0.2232 0.218884 0.188841 0.44206 0.55794 0.360515 0.16309 0.309013 0.167382 0.472103 0.527897 0.399142 0.223176 0.180258 0.197425 0.403433 0.596567 0.347639 0.283262 0.167382 0.201717 0.450644 0.549356 0.577177 25898.315 -0.755603 0.301724 0.508621 0.181034 0.099138 0.474138 0.525862 0.275862 0.176724 0.099138 9.463554 9.241379 NMV_1751 2192713 CDS -3 1690641 1691018 378 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:30:22 no 25569427 3 vladimir 0.34127 0.1190 0.216931 0.322751 0.335979 0.664021 0.34127 0.111111 0.309524 0.238095 0.420635 0.579365 0.428571 0.103175 0.150794 0.31746 0.253968 0.746032 0.253968 0.142857 0.190476 0.412698 0.333333 0.666667 0.51758 15289.98 -0.4872 0.112 0.392 0.232 0.184 0.568 0.432 0.32 0.136 0.184 4.72187 9.976 NMV_1752 2192714 CDS -3 1691049 1691450 402 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-19 17:51:07 no 25569427 3 vladimir 0.328321 0.1128 0.230576 0.328321 0.343358 0.656642 0.345865 0.112782 0.278196 0.263158 0.390977 0.609023 0.383459 0.090226 0.203008 0.323308 0.293233 0.706767 0.255639 0.135338 0.210526 0.398496 0.345865 0.654135 0.509805 16455.405 -0.562121 0.106061 0.348485 0.212121 0.19697 0.545455 0.454545 0.356061 0.174242 0.181818 5.529366 9.886364 NMV_1753 2192715 CDS -1 1691453 1691980 528 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 17:36:43 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.446154 0.1179 0.215385 0.220513 0.333333 0.666667 0.446154 0.092308 0.292308 0.169231 0.384615 0.615385 0.430769 0.184615 0.230769 0.153846 0.415385 0.584615 0.461538 0.076923 0.123077 0.338462 0.2 0.8 0.385524 7337.925 -1.404688 0.28125 0.484375 0.125 0.09375 0.375 0.625 0.40625 0.28125 0.125 10.280128 9.140625 NMV_1754 2192716 CDS -2 1692028 1692363 336 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 15:44:03 no 25569427 1 vladimir 0.303571 0.1548 0.238095 0.303571 0.392857 0.607143 0.303571 0.116071 0.330357 0.25 0.446429 0.553571 0.383929 0.169643 0.133929 0.3125 0.303571 0.696429 0.223214 0.178571 0.25 0.348214 0.428571 0.571429 0.624031 12718.06 -0.379279 0.234234 0.423423 0.198198 0.108108 0.495495 0.504505 0.351351 0.153153 0.198198 4.774315 8.963964 NMV_1755 2192717 CDS -3 1692360 1693091 732 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-24 17:36:58 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 1 vladimir 0.348361 0.2145 0.218579 0.218579 0.43306 0.56694 0.344262 0.180328 0.32377 0.151639 0.504098 0.495902 0.418033 0.209016 0.17623 0.196721 0.385246 0.614754 0.282787 0.254098 0.155738 0.307377 0.409836 0.590164 0.588951 27022.04 -0.839095 0.296296 0.534979 0.18107 0.111111 0.45679 0.54321 0.263374 0.176955 0.08642 9.721825 9.226337 NMV_1756 2192718 CDS -2 1693225 1693542 318 validated/Curated no mafI2 MafB2 immunity protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2015-11-13 15:40:15 no 25569427 3 vladimir 0.355346 0.1258 0.220126 0.298742 0.345912 0.654088 0.349057 0.084906 0.292453 0.273585 0.377359 0.622642 0.349057 0.160377 0.160377 0.330189 0.320755 0.679245 0.367925 0.132075 0.207547 0.292453 0.339623 0.660377 0.443535 12342.69 -0.193333 0.228571 0.380952 0.228571 0.133333 0.533333 0.466667 0.285714 0.12381 0.161905 4.82206 10.171429 NMV_1757 2192719 CDS -3 1693545 1694798 1254 validated/Curated no mafB2 MafB2 toxin 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 10 : Secreted 2015-11-13 15:38:13 no 25569427 2 vladimir 0.295853 0.2919 0.23126 0.181021 0.523126 0.476874 0.301435 0.203349 0.361244 0.133971 0.564593 0.435407 0.373206 0.239234 0.186603 0.200957 0.425837 0.574163 0.212919 0.433014 0.145933 0.208134 0.578947 0.421053 0.622732 45233.04 -0.706715 0.323741 0.570743 0.151079 0.127098 0.501199 0.498801 0.261391 0.158273 0.103118 8.658623 9.513189 NMV_1759 2192721 CDS -3 1694802 1695743 942 validated/Curated no mafA2 MafA2 lipoprotein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 8 : Outer membrane-associated 2008-05-01 11:51:30 no 2 vladimir 0.255839 0.3832 0.211253 0.149682 0.59448 0.40552 0.267516 0.232484 0.359873 0.140127 0.592357 0.407643 0.299363 0.280255 0.178344 0.242038 0.458599 0.541401 0.200637 0.636943 0.095541 0.066879 0.732484 0.267516 0.701262 33927.9 -0.342173 0.354633 0.57508 0.201278 0.089457 0.527157 0.472843 0.226837 0.124601 0.102236 8.926079 9.485623 NMV_1760 2192722 CDS -1 1695866 1696255 390 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:51:10 no 3 vladimir 0.305128 0.1692 0.202564 0.323077 0.371795 0.628205 0.284615 0.146154 0.307692 0.261538 0.453846 0.546154 0.346154 0.176923 0.115385 0.361538 0.292308 0.707692 0.284615 0.184615 0.184615 0.346154 0.369231 0.630769 0.59681 14746.57 0.034109 0.186047 0.426357 0.255814 0.147287 0.604651 0.395349 0.271318 0.116279 0.155039 4.710335 7.930233 NMV_1761 2192723 CDS -2 1696258 1696503 246 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:50:59 no 3 vladimir 0.378049 0.1667 0.243902 0.211382 0.410569 0.589431 0.378049 0.182927 0.292683 0.146341 0.47561 0.52439 0.402439 0.207317 0.195122 0.195122 0.402439 0.597561 0.353659 0.109756 0.243902 0.292683 0.353659 0.646341 0.468665 9223.06 -0.992593 0.308642 0.419753 0.148148 0.123457 0.407407 0.592593 0.37037 0.246914 0.123457 9.629433 9.037037 NMV_1762 2192724 CDS -3 1696581 1696823 243 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-19 14:41:50 no 25569427 3 vladimir 0.386831 0.0864 0.17284 0.353909 0.259259 0.740741 0.382716 0.049383 0.283951 0.283951 0.333333 0.666667 0.419753 0.111111 0.148148 0.320988 0.259259 0.740741 0.358025 0.098765 0.08642 0.45679 0.185185 0.814815 0.469083 9269.385 -0.22875 0.2125 0.4125 0.2625 0.1375 0.55 0.45 0.3125 0.15 0.1625 5.325356 8.6125 NMV_1763 2192725 CDS -2 1696981 1697400 420 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:50:38 no 3 vladimir 0.333333 0.1286 0.190476 0.347619 0.319048 0.680952 0.264286 0.135714 0.3 0.3 0.435714 0.564286 0.428571 0.15 0.135714 0.285714 0.285714 0.714286 0.307143 0.1 0.135714 0.457143 0.235714 0.764286 0.553841 16163.37 -0.333813 0.23741 0.453237 0.208633 0.18705 0.517986 0.482014 0.23741 0.086331 0.151079 4.412224 9.345324 NMV_1764 2192726 CDS -3 1697427 1697675 249 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:50:28 no 3 vladimir 0.393574 0.1124 0.26506 0.228916 0.37751 0.62249 0.39759 0.108434 0.337349 0.156627 0.445783 0.554217 0.373494 0.204819 0.26506 0.156627 0.46988 0.53012 0.409639 0.024096 0.192771 0.373494 0.216867 0.783133 0.441275 9485.325 -1.293902 0.280488 0.45122 0.097561 0.109756 0.439024 0.560976 0.378049 0.219512 0.158537 9.475838 9.792683 NMV_1765 2192727 CDS -2 1697701 1698162 462 validated/Curated no mafI MafB immunity protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2015-11-13 15:50:20 no 25569427 3 vladimir 0.378788 0.1234 0.177489 0.320346 0.300866 0.699134 0.324675 0.123377 0.279221 0.272727 0.402597 0.597403 0.415584 0.149351 0.11039 0.324675 0.25974 0.74026 0.396104 0.097403 0.142857 0.363636 0.24026 0.75974 0.456149 17947.73 -0.233333 0.176471 0.405229 0.228758 0.169935 0.555556 0.444444 0.24183 0.091503 0.150327 4.529503 9.379085 NMV_1766 2192728 CDS -1 1698173 1700572 2400 validated/Curated no mafB MafB toxin 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 10 : Secreted 2015-11-19 17:50:00 no 25569427 1 vladimir 0.296667 0.2588 0.242083 0.2025 0.500833 0.499167 0.29625 0.215 0.33875 0.15 0.55375 0.44625 0.32875 0.255 0.195 0.22125 0.45 0.55 0.265 0.30625 0.1925 0.23625 0.49875 0.50125 0.544397 86713.24 -0.602628 0.307885 0.553191 0.178974 0.093867 0.52816 0.47184 0.252816 0.162703 0.090113 9.808128 9.359199 NMV_tRNA_39 2194854 tRNA -1 1700731 1700807 77 validated/Curated no Pro tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:57:33 no tRNA Pro anticodon GGG. vladimir NMV_1767 2192729 CDS +3 1701018 1701476 459 validated/Curated no nudB dihydroneopterin triphosphate diphosphatase (dATP pyrophosphohydrolase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 3.6.1.67 H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN$RXN0-384 PWY-6147 2020-02-19 14:10:56 no Catalyses the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyse nucleoside triphosphates with a preference for dATP. 2 vladimir 0.237473 0.3028 0.281046 0.178649 0.583878 0.416122 0.189542 0.281046 0.359477 0.169935 0.640523 0.359477 0.313726 0.215686 0.20915 0.261438 0.424837 0.575163 0.20915 0.411765 0.27451 0.104575 0.686275 0.313725 0.653329 17427.065 -0.456579 0.256579 0.434211 0.210526 0.157895 0.552632 0.447368 0.296053 0.151316 0.144737 5.632439 9.809211 NMV_1768 2192730 CDS +2 1701578 1702111 534 validated/Curated no ppa inorganic pyrophosphatase (pyrophosphate phospho-hydrolase; PPase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.1 : Phosphorous metabolism ; 3.6.1.1 INORGPYROPHOSPHAT-RXN 2018-01-24 17:38:07 no Catalyses the following reaction: diphosphate + H(2)O <=> 2 phosphate. 2 vladimir 0.305243 0.2978 0.228464 0.168539 0.526217 0.473783 0.280899 0.179775 0.404494 0.134831 0.58427 0.41573 0.404494 0.185393 0.123596 0.286517 0.308989 0.691011 0.230337 0.52809 0.157303 0.08427 0.685393 0.314607 0.85153 19810.52 -0.416949 0.220339 0.508475 0.231638 0.096045 0.519774 0.480226 0.305085 0.129944 0.175141 4.704674 9.242938 NMV_1769 2192731 CDS +1 1702219 1702452 234 validated/Curated no hypothetical membrane-associated protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 11:49:11 no 2 vladimir 0.17094 0.3376 0.222222 0.269231 0.559829 0.440171 0.153846 0.294872 0.294872 0.25641 0.589744 0.410256 0.153846 0.269231 0.166667 0.410256 0.435897 0.564103 0.205128 0.448718 0.205128 0.141026 0.653846 0.346154 0.55924 8386.74 0.885714 0.350649 0.454545 0.298701 0.155844 0.714286 0.285714 0.116883 0.116883 0 11.080467 8.090909 NMV_1770 2192732 CDS +2 1702445 1703044 600 validated/Curated no rdgB dITP/XTP pyrophosphatase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.33 : Nucleotide and nucleoside conversions ; 3.6.1.66 2020-02-19 13:06:41 no Pyrophosphatase that catalyses the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. 2 vladimir 0.25 0.3183 0.243333 0.188333 0.561667 0.438333 0.195 0.225 0.41 0.17 0.635 0.365 0.33 0.26 0.18 0.23 0.44 0.56 0.225 0.47 0.14 0.165 0.61 0.39 0.685033 21333.27 -0.225628 0.331658 0.547739 0.190955 0.120603 0.60804 0.39196 0.256281 0.130653 0.125628 5.638634 9.442211 NMV_1771 2192733 CDS +2 1703072 1703941 870 validated/Curated no galU UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase; UDPGP; alpha-D-glucosyl-1-phosphate uridylyltransferase; uridine diphosphoglucose pyrophosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.7.9 GLUC1PURIDYLTRANS-RXN 2018-01-24 17:41:38 no Catalyses the following reaction: UTP + alpha-D-glucose 1-phosphate <=> diphosphate + UDP-glucose. 2 vladimir 0.25977 0.3230 0.245977 0.171264 0.568966 0.431034 0.241379 0.248276 0.382759 0.127586 0.631034 0.368966 0.313793 0.217241 0.172414 0.296552 0.389655 0.610345 0.224138 0.503448 0.182759 0.089655 0.686207 0.313793 0.6914 31983.75 -0.162976 0.269896 0.467128 0.242215 0.093426 0.581315 0.418685 0.287197 0.145329 0.141869 5.748329 9.695502 NMV_1772 2192734 CDS +2 1703960 1705336 1377 validated/Curated no argH argininosuccinate lyase (arginosuccinase; ASAL) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 4.3.2.1 ARGSUCCINLYA-RXN ARGSYN-PWY$ARGSYNBSUB-PWY 2018-01-24 17:42:08 no Catalyses the following reaction: (N(omega)-L-arginino)succinate <=> fumarate + L-arginine. 2 vladimir 0.236747 0.3086 0.254176 0.200436 0.562818 0.437182 0.237473 0.244009 0.37037 0.148148 0.614379 0.385621 0.30719 0.20915 0.178649 0.305011 0.3878 0.6122 0.165577 0.472767 0.213508 0.148148 0.686274 0.313725 0.752356 51299.555 -0.242358 0.268559 0.478166 0.229258 0.08952 0.534934 0.465066 0.281659 0.135371 0.146288 5.216408 9.676856 NMV_1773 2192735 CDS +2 1705394 1705864 471 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:48:26 no 2 vladimir 0.301486 0.2484 0.2569 0.193206 0.505308 0.494692 0.267516 0.254777 0.318471 0.159236 0.573248 0.426752 0.394904 0.178344 0.171975 0.254777 0.350318 0.649682 0.242038 0.312102 0.280255 0.165605 0.592357 0.407643 0.654488 18061.735 -0.598077 0.24359 0.429487 0.185897 0.134615 0.50641 0.49359 0.288462 0.141026 0.147436 5.325356 9.50641 NMV_1774 2192736 CDS +3 1706115 1707110 996 validated/Curated no fbpA major ferric iron-binding protein (iron(III)-transport system iron-binding protein FbpB; FBP; major iron-regulated protein; MIRP; Iron(III) periplasmic binding protein) 1c : Function from experimental evidences in the studied genus rc : receptor 9 : Periplasmic 2018-01-24 17:42:55 no 10425707, 8606197 Is a central component in the iron-acquisition system in Neisseria species. 2 vladimir 0.271084 0.3283 0.22992 0.170683 0.558233 0.441767 0.25 0.213855 0.394578 0.141566 0.608434 0.391566 0.325301 0.304217 0.129518 0.240964 0.433735 0.566265 0.237952 0.466867 0.165663 0.129518 0.63253 0.36747 0.708351 35826.52 -0.249547 0.335347 0.534743 0.21148 0.090634 0.549849 0.450151 0.250755 0.154079 0.096677 9.599525 9.069486 NMV_1775 2192737 CDS +1 1707166 1708695 1530 validated/Curated no fbpB iron(III)-transport system permease protein FbpB 1c : Function from experimental evidences in the studied genus t : transporter 5 : Inner membrane protein 2008-06-17 16:38:11 no 8606197 2 vladimir 0.196732 0.3039 0.214379 0.284967 0.518301 0.481699 0.27451 0.219608 0.264706 0.241176 0.484314 0.515686 0.164706 0.262745 0.147059 0.42549 0.409804 0.590196 0.15098 0.429412 0.231373 0.188235 0.660784 0.339216 0.652623 56360.63 0.862672 0.306483 0.467583 0.318271 0.139489 0.689587 0.310413 0.119843 0.082515 0.037328 9.670662 8.314342 NMV_1776 2192738 CDS +3 1708716 1709774 1059 validated/Curated no fbpC iron(III)-transport system ATP-binding protein FbpC (ferric cations import ATP-binding protein FbpC) 1c : Function from experimental evidences in the studied genus t : transporter 1 : Unknown 7.2.2.7 2020-04-21 13:33:26 no 15126492 2 vladimir 0.20491 0.3673 0.238905 0.188857 0.606232 0.393768 0.206799 0.311615 0.345609 0.135977 0.657224 0.342776 0.249292 0.269122 0.192635 0.288952 0.461756 0.538244 0.15864 0.521246 0.17847 0.141643 0.699717 0.300283 0.633632 37879.885 -0.06392 0.329545 0.514205 0.241477 0.085227 0.573864 0.426136 0.224432 0.125 0.099432 6.640312 9.161932 NMV_1777 2192739 CDS +1 1709959 1711461 1503 validated/Curated no pta phosphate acetyltransferase (phosphotransacetylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.5 : Fermentation ; 2.3.1.8 PHOSACETYLTRANS-RXN FERMENTATION-PWY$PWY-5482$PWY-5485$PWY0-1312 2018-01-29 22:29:13 no Catalyses the following reaction: acetyl-CoA + phosphate <=> CoA + acetyl phosphate. 2 vladimir 0.228876 0.3400 0.262142 0.168995 0.602129 0.397871 0.207585 0.219561 0.45509 0.117764 0.674651 0.325349 0.265469 0.303393 0.137725 0.293413 0.441118 0.558882 0.213573 0.497006 0.193613 0.095808 0.690619 0.309381 0.773693 52099.415 0.1724 0.35 0.604 0.244 0.052 0.606 0.394 0.214 0.096 0.118 4.868416 9.002 NMV_1778 2192740 CDS +3 1711593 1712231 639 validated/Curated no hisH imidazole glycerol phosphate synthase subunit HisH (IGP synthase glutamine amidotransferase subunit; IGP synthase subunit HisH; ImGP synthase subunit HisH; IGPS subunit HisH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 4.3.2.10 GLUTAMIDOTRANS-RXN HISTSYN-PWY 2020-02-19 18:00:18 no Is a key metabolic enzyme, which links amino acid and nucleotide biosynthesis: it catalyses the closure of the imidazole ring within histidine biosynthesis (fifth step), and provides the substrate for de novo purine biosynthesis. 2 vladimir 0.256651 0.2958 0.250391 0.197183 0.546166 0.453834 0.253521 0.220657 0.338028 0.187793 0.558685 0.441315 0.323944 0.197183 0.206573 0.2723 0.403756 0.596244 0.192488 0.469484 0.206573 0.131455 0.676056 0.323944 0.684925 23700.925 -0.403302 0.283019 0.514151 0.174528 0.141509 0.551887 0.448113 0.259434 0.141509 0.117925 6.405113 9.589623 NMV_1779 2192741 CDS +2 1712264 1713001 738 validated/Curated no hisA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 5.3.1.16 PRIBFAICARPISOM-RXN HISTSYN-PWY 2018-01-24 17:45:10 no Catalyses the fourth step in histidine biosynthesis: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide <=> 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. 2 vladimir 0.224932 0.3049 0.285908 0.184282 0.590786 0.409214 0.239837 0.199187 0.447154 0.113821 0.646341 0.353659 0.268293 0.223577 0.195122 0.313008 0.418699 0.581301 0.166667 0.49187 0.215447 0.126016 0.707317 0.292683 0.714301 25905.64 0.189388 0.326531 0.55102 0.265306 0.069388 0.62449 0.37551 0.244898 0.114286 0.130612 4.98484 9.216327 NMV_1780 2192742 CDS +2 1713014 1713781 768 validated/Curated no hisF imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 4.3.2.10 GLUTAMIDOTRANS-RXN HISTSYN-PWY 2020-02-19 18:02:33 no Is a cyclase that catalyses the cyclisation reaction that produces D-erythro-imidazole glycerol phosphate during the sixth step of histidine biosynthesis. 2 vladimir 0.217448 0.3385 0.282552 0.161458 0.621094 0.378906 0.238281 0.191406 0.488281 0.082031 0.679688 0.320312 0.253906 0.238281 0.207031 0.300781 0.445312 0.554688 0.160156 0.585938 0.152344 0.101562 0.738281 0.261719 0.750373 27013.67 0.049412 0.329412 0.568627 0.25098 0.062745 0.6 0.4 0.270588 0.129412 0.141176 5.240227 9.827451 NMV_1781 2192743 CDS +2 1713812 1714207 396 validated/Curated no hisI phosphoribosyl-AMP cyclohydrolase (PRA-CH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 3.5.4.19 HISTCYCLOHYD-RXN HISTSYN-PWY 2018-01-24 17:45:51 no Catalyses the third step in the histidine biosynthetic pathway: 1-(5-phosphoribosyl)-AMP + H(2)O <=> 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. 2 vladimir 0.282828 0.2727 0.275253 0.169192 0.54798 0.45202 0.265152 0.181818 0.401515 0.151515 0.583333 0.416667 0.356061 0.181818 0.227273 0.234848 0.409091 0.590909 0.227273 0.454545 0.19697 0.121212 0.651515 0.348485 0.748737 14772.21 -0.445038 0.320611 0.473282 0.175573 0.114504 0.519084 0.480916 0.312977 0.167939 0.145038 6.475395 10.015267 NMV_1782 2192744 CDS +3 1714314 1715909 1596 validated/Curated no prfC peptide chain release factor III (RF-3) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-24 17:46:08 no Increases the formation of ribosomal termination complexes and stimulates activity of RF-1 and RF-2. It binds to guanine nucleotides and has a strong preference for UGA stop codons. 2 vladimir 0.260025 0.2907 0.25188 0.197368 0.542607 0.457393 0.259398 0.216165 0.357143 0.167293 0.573308 0.426692 0.325188 0.201128 0.159774 0.31391 0.360902 0.639098 0.195489 0.454887 0.238722 0.110902 0.693609 0.306391 0.72819 59605.79 -0.218079 0.254237 0.467043 0.233522 0.105461 0.53484 0.46516 0.280603 0.137476 0.143126 5.428749 9.205273 NMV_1783 2192745 CDS +2 1716038 1716115 78 validated/Curated partial prfc' truncated peptide chain release factor 3 (C-terminal 5% of the protein) 5 : Unknown function f : factor 2 : Cytoplasmic 2008-05-01 11:45:16 no 2 vladimir 0.282051 0.2308 0.269231 0.217949 0.5 0.5 0.230769 0.307692 0.269231 0.192308 0.576923 0.423077 0.384615 0.153846 0.153846 0.307692 0.307692 0.692308 0.230769 0.230769 0.384615 0.153846 0.615385 0.384615 0.497823 3036.35 -0.656 0.16 0.36 0.24 0.16 0.44 0.56 0.36 0.2 0.16 6.030098 10 NMV_1784 2192746 CDS -1 1716272 1716802 531 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:44:57 no 2 vladimir 0.216573 0.2768 0.312618 0.193974 0.589454 0.410546 0.242938 0.20339 0.423729 0.129944 0.627119 0.372881 0.271186 0.19774 0.214689 0.316384 0.412429 0.587571 0.135593 0.429379 0.299435 0.135593 0.728814 0.271186 0.673732 18971.055 0.069886 0.306818 0.568182 0.272727 0.079545 0.585227 0.414773 0.25 0.136364 0.113636 6.29232 9.835227 NMV_1785 2192747 fCDS -3 1716843 1717511 669 validated/Curated pseudo pglE pilin glycosyl transferase E (pseudogene part 2) 1b : Function from experimental evidences in the studied species e : enzyme 5 : Inner membrane protein 2018-01-24 17:47:21 no 12864863 Is involved in pilin glycosylation. 3 vladimir 0.343797 0.1106 0.206278 0.339312 0.316891 0.683109 0.35426 0.09417 0.264574 0.286996 0.358744 0.641256 0.363229 0.147982 0.143498 0.345291 0.29148 0.70852 0.313901 0.089686 0.210762 0.38565 0.300448 0.699552 0.43206 26022.445 -0.110811 0.216216 0.382883 0.256757 0.148649 0.545045 0.454955 0.297297 0.166667 0.130631 8.953529 8.635135 NMV_1786 2192748 fCDS -1 1717724 1718095 372 validated/Curated pseudo pglE pilin glycosyl transferase E (pseudogene part 1) 1b : Function from experimental evidences in the studied species e : enzyme 5 : Inner membrane protein 2018-01-24 17:47:32 no 12864863 Is involved in pilin glycosylation. 3 vladimir 0.565134 0.2184 0.091954 0.124521 0.310345 0.689655 0.563218 0.212644 0.137931 0.086207 0.350575 0.649425 0.563218 0.224138 0.074713 0.137931 0.298851 0.701149 0.568965 0.218391 0.063218 0.149425 0.281609 0.718391 0.469461 19826.68 -1.587861 0.265896 0.531792 0.132948 0.034682 0.231214 0.768786 0.202312 0.121387 0.080925 9.283577 9.728324 NMV_1787 2192749 CDS -1 1718228 1719367 1140 validated/Curated no putative spermidine/putrescine-binding lipoprotein 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 1.7.14 : Polyamine biosynthesis ; 2018-01-24 17:47:51 no This usually periplasmic spermidine/putrescine-binding protein is involved in the polyamine transport system. It is required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. 2 vladimir 0.277193 0.2921 0.259649 0.171053 0.551754 0.448246 0.297368 0.155263 0.384211 0.163158 0.539474 0.460526 0.35 0.265789 0.15 0.234211 0.415789 0.584211 0.184211 0.455263 0.244737 0.115789 0.7 0.3 0.736347 41191.95 -0.358575 0.324538 0.548813 0.187335 0.092348 0.551451 0.448549 0.253298 0.124011 0.129288 5.509926 9.237467 NMV_1788 2192750 CDS -2 1719640 1720263 624 validated/Curated no lolA outer-membrane lipoprotein carrier protein LolA 2a : Function from experimental evidences in other organisms c : carrier 9 : Periplasmic 1.6.10 : Lipoprotein ; 2018-01-31 20:24:46 no Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. 2 vladimir 0.258013 0.3349 0.233974 0.173077 0.56891 0.43109 0.3125 0.201923 0.307692 0.177885 0.509615 0.490385 0.317308 0.254808 0.177885 0.25 0.432692 0.567308 0.144231 0.548077 0.216346 0.091346 0.764423 0.235577 0.724626 22230.09 -0.300966 0.362319 0.570048 0.183575 0.10628 0.521739 0.478261 0.173913 0.10628 0.067633 9.362617 8.362319 NMV_1789 2192751 CDS +2 1720691 1721518 828 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:44:09 no 1 vladimir 0.216184 0.2669 0.304348 0.21256 0.571256 0.428744 0.195652 0.246377 0.384058 0.173913 0.630435 0.369565 0.311594 0.213768 0.184783 0.289855 0.398551 0.601449 0.141304 0.34058 0.344203 0.173913 0.684783 0.315217 0.686199 31395.74 -0.297091 0.247273 0.465455 0.203636 0.138182 0.578182 0.421818 0.301818 0.16 0.141818 6.278862 10.24 NMV_1790 2192752 CDS +2 1721531 1722193 663 validated/Curated no putative phosphatase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.3.- 2018-01-22 15:52:10 no Belongs to the HAD hydrolase, subfamily IA. 2 vladimir 0.250377 0.3756 0.230769 0.143288 0.606335 0.393665 0.244344 0.285068 0.371041 0.099548 0.656109 0.343891 0.312217 0.230769 0.19457 0.262443 0.425339 0.574661 0.19457 0.61086 0.126697 0.067873 0.737557 0.262443 0.6357 24236.615 -0.259545 0.295455 0.504545 0.218182 0.104545 0.577273 0.422727 0.272727 0.127273 0.145455 5.001396 9.509091 NMV_1791 2192753 CDS -3 1722432 1723253 822 validated/Curated no ppsR phosphoenolpyruvate synthase regulatory protein 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.7.11.33, 2.7.4.28 2017-10-26 00:07:16 no 20044937 1 vladimir 0.238443 0.2445 0.288321 0.22871 0.532847 0.467153 0.273723 0.248175 0.324818 0.153285 0.572993 0.427007 0.332117 0.215328 0.182482 0.270073 0.39781 0.60219 0.109489 0.270073 0.357664 0.262774 0.627737 0.372263 0.579011 30964.94 -0.509158 0.263736 0.479853 0.201465 0.106227 0.487179 0.512821 0.300366 0.168498 0.131868 8.40847 9.732601 NMV_1792 2192754 CDS +2 1723664 1726048 2385 validated/Curated no ppsA phosphoenolpyruvate synthase (pyruvate, water dikinase; PEP synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 2.7.9.2 PEPSYNTH-RXN GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-31 15:03:13 no Catalyses the following reaction: ATP + pyruvate + H(2)O <=> AMP + phosphoenolpyruvate + phosphate. 1 vladimir 0.251992 0.2906 0.254507 0.202935 0.545073 0.454927 0.245283 0.181132 0.413836 0.159748 0.594969 0.405031 0.319497 0.221384 0.167296 0.291824 0.388679 0.611321 0.191195 0.469182 0.18239 0.157233 0.651572 0.348428 0.822816 87152.455 -0.199496 0.290932 0.526448 0.221662 0.089421 0.555416 0.444584 0.27204 0.124685 0.147355 5.005562 9.759446 NMV_1793 2192755 CDS +2 1726268 1727527 1260 validated/Curated no rho transcription termination factor Rho 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-24 18:05:29 no Disengages newly transcribed RNA from its DNA template at certain specific transcripts. 2 vladimir 0.261905 0.3095 0.234127 0.194444 0.543651 0.456349 0.266667 0.252381 0.347619 0.133333 0.6 0.4 0.321429 0.202381 0.159524 0.316667 0.361905 0.638095 0.197619 0.47381 0.195238 0.133333 0.669048 0.330952 0.714077 47303.61 -0.313126 0.24105 0.453461 0.243437 0.088305 0.513126 0.486874 0.310263 0.164678 0.145585 6.36367 9.579952 NMV_1794 2192756 CDS +3 1727832 1727936 105 validated/Curated partial truncated IS1016 group transposase (N-terminal 16% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-01 11:42:47 no 3 vladimir 0.380952 0.1524 0.228571 0.238095 0.380952 0.619048 0.371429 0.171429 0.342857 0.114286 0.514286 0.485714 0.285714 0.171429 0.228571 0.314286 0.4 0.6 0.485714 0.114286 0.114286 0.285714 0.228571 0.771429 0.37289 3820.355 -0.114706 0.294118 0.470588 0.264706 0.058824 0.529412 0.470588 0.264706 0.205882 0.058824 11.000252 9.764706 NMV_1795 2192757 CDS +1 1727998 1728207 210 validated/Curated partial truncated IS1016 group transposase (internal 32% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-01 11:42:36 no 3 vladimir 0.333333 0.1476 0.228571 0.290476 0.37619 0.62381 0.271429 0.2 0.314286 0.214286 0.514286 0.485714 0.442857 0.085714 0.185714 0.285714 0.271429 0.728571 0.285714 0.157143 0.185714 0.371429 0.342857 0.657143 0.525472 8360.12 -0.804348 0.144928 0.347826 0.173913 0.202899 0.492754 0.507246 0.362319 0.202899 0.15942 7.039467 10.289855 NMV_1796 2192758 CDS +3 1728402 1728797 396 validated/Curated partial truncated ISNme1 transposase (C-terminal third of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-24 18:08:04 no Belongs to the IS5 family. 2 vladimir 0.257576 0.2702 0.267677 0.204545 0.537879 0.462121 0.257576 0.25 0.280303 0.212121 0.530303 0.469697 0.340909 0.234848 0.19697 0.227273 0.431818 0.568182 0.174242 0.325758 0.325758 0.174242 0.651515 0.348485 0.628315 14832.53 -0.496947 0.320611 0.442748 0.19084 0.122137 0.503817 0.496183 0.290076 0.21374 0.076336 9.967918 9.656489 NMV_1798 2192760 CDS +2 1729994 1731298 1305 validated/Curated no putative ammonium transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.49 : The Ammonium Transporter (Amt) Family ; RXN-9615 PWY-5986 2008-05-01 11:40:08 no 1 vladimir 0.177778 0.2475 0.325671 0.249042 0.57318 0.42682 0.227586 0.14023 0.413793 0.218391 0.554023 0.445977 0.165517 0.271264 0.211494 0.351724 0.482759 0.517241 0.14023 0.331034 0.351724 0.177011 0.682759 0.317241 0.616287 45382.315 0.681106 0.391705 0.559908 0.24424 0.131336 0.730415 0.269585 0.129032 0.080645 0.048387 9.054466 8.937788 NMV_1799 2192761 CDS -3 1731543 1732838 1296 validated/Curated no putative FAD-dependent oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.-.-.- 2018-01-22 18:26:24 no 1 vladimir 0.23534 0.2446 0.266204 0.253858 0.510802 0.489198 0.219907 0.24537 0.333333 0.201389 0.578704 0.421296 0.333333 0.199074 0.203704 0.263889 0.402778 0.597222 0.152778 0.289352 0.261574 0.296296 0.550926 0.449074 0.638408 48661.51 -0.29884 0.280742 0.459397 0.208817 0.139211 0.575406 0.424594 0.238979 0.12761 0.111369 6.137764 9.798144 NMV_1800 2192762 CDS -2 1732960 1733853 894 validated/Curated no putative spermidine/putrescine transport system permease protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:39:38 no 1 vladimir 0.201342 0.2450 0.253915 0.299776 0.498881 0.501119 0.261745 0.211409 0.285235 0.241611 0.496644 0.503356 0.194631 0.238255 0.14094 0.426174 0.379195 0.620805 0.147651 0.285235 0.33557 0.231544 0.620805 0.379195 0.668438 32970.22 0.722559 0.282828 0.434343 0.329966 0.107744 0.6633 0.3367 0.154882 0.090909 0.063973 9.43087 8.272727 NMV_1801 2192763 CDS -3 1733853 1734818 966 validated/Curated no putative spermidine/putrescine transport system permease protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:39:23 no 1 vladimir 0.212215 0.2547 0.242236 0.29089 0.496894 0.503106 0.279503 0.229814 0.279503 0.21118 0.509317 0.490683 0.242236 0.220497 0.124224 0.413043 0.34472 0.655279 0.114907 0.313665 0.322981 0.248447 0.636646 0.363354 0.717937 35968.18 0.596573 0.23676 0.46729 0.320872 0.130841 0.672897 0.327103 0.137072 0.071651 0.065421 6.362816 8.741433 NMV_1802 2192764 CDS -3 1734834 1735958 1125 validated/Curated no putative spermidine/putrescine transport system ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2008-05-01 11:39:08 no 1 vladimir 0.275556 0.2604 0.240889 0.223111 0.501333 0.498667 0.290667 0.242667 0.322667 0.144 0.565333 0.434667 0.346667 0.197333 0.168 0.288 0.365333 0.634667 0.189333 0.341333 0.232 0.237333 0.573333 0.426667 0.704831 42154.585 -0.332888 0.251337 0.462567 0.224599 0.106952 0.545455 0.454545 0.248663 0.122995 0.125668 5.474892 9.435829 NMV_1803 2192765 CDS -1 1736339 1736608 270 validated/Curated no rpsO 30S ribosomal protein S15 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 18:09:07 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.266667 0.3333 0.214815 0.185185 0.548148 0.451852 0.255556 0.344444 0.255556 0.144444 0.6 0.4 0.322222 0.2 0.2 0.277778 0.4 0.6 0.222222 0.455556 0.188889 0.133333 0.644444 0.355556 0.86941 10385.71 -0.68427 0.235955 0.404494 0.224719 0.089888 0.449438 0.550562 0.337079 0.247191 0.089888 11.175529 9.516854 NMNmisc_RNA1736552R 19685107 misc_RNA -1 1736603 1736707 105 validated/Curated no ribosomal S15 leader 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 18:38:10 28334889 The ribosomal S15 leader is an RNA element that can form two alternative structures found in the ribosomal S15 protein (encoded by NMV_1803). One of the two alternate structures is a series of three hairpins, the other includes a pseudoknot. This structure causes translational regulation of the S15 protein. vladimir NMV_1804 2192766 CDS -1 1736831 1737766 936 validated/Curated no secF protein translocase SecF subunit 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:18:47 no Part of the prokaryotic protein translocation apparatus essential for protein export. 1 vladimir 0.227564 0.2361 0.25641 0.279915 0.492521 0.507479 0.298077 0.163462 0.346154 0.192308 0.509615 0.490385 0.237179 0.192308 0.153846 0.416667 0.346154 0.653846 0.147436 0.352564 0.269231 0.230769 0.621795 0.378205 0.737671 34369.1 0.486817 0.270096 0.4791 0.299035 0.109325 0.614148 0.385852 0.196141 0.106109 0.090032 7.134422 8.877814 NMV_1805 2192767 CDS -1 1737770 1739623 1854 validated/Curated no secD protein translocase SecD subunit 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:19:28 no Part of the prokaryotic protein translocation apparatus essential for protein export. 1 vladimir 0.231018 0.2520 0.281637 0.235326 0.533656 0.466344 0.276252 0.200323 0.368336 0.155089 0.568659 0.431341 0.258481 0.242326 0.169628 0.329564 0.411955 0.588045 0.15832 0.313409 0.306947 0.221325 0.620355 0.379645 0.69316 66894.525 0.11068 0.31068 0.522654 0.263754 0.067961 0.579288 0.420712 0.205502 0.105178 0.100324 6.353523 9.195793 NMV_1806 2192768 CDS -3 1739835 1740101 267 validated/Curated no putative Sec translocon accessory complex subunit 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 2018-01-24 18:11:04 no 27435098 1 vladimir 0.277154 0.1948 0.273408 0.254682 0.468165 0.531835 0.269663 0.157303 0.426966 0.146067 0.58427 0.41573 0.303371 0.191011 0.11236 0.393258 0.303371 0.696629 0.258427 0.235955 0.280899 0.224719 0.516854 0.483146 0.664472 9708.155 0.3625 0.238636 0.465909 0.272727 0.102273 0.636364 0.363636 0.227273 0.147727 0.079545 9.821266 9.102273 NMV_1807 2192769 CDS +1 1740181 1741338 1158 validated/Curated no putative deacetylase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-02-19 13:07:31 no Belongs to the histone deacetylases protein superfamily, which catalyse the removal of the acetyl group from lysine residues on histones. 2 vladimir 0.22973 0.3315 0.25045 0.188288 0.581982 0.418018 0.213514 0.283784 0.343243 0.159459 0.627027 0.372973 0.281081 0.267568 0.189189 0.262162 0.456757 0.543243 0.194595 0.443243 0.218919 0.143243 0.662162 0.337838 0.650392 40664.94 -0.239024 0.317073 0.504065 0.197832 0.121951 0.566396 0.433604 0.265583 0.159892 0.105691 8.836571 9.314363 NMV_1808 2192770 CDS +3 1741701 1742765 1065 validated/Curated no putative zinc-dependent oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.1.- 2018-01-19 19:12:10 no 2 vladimir 0.246009 0.2920 0.264789 0.197183 0.556808 0.443192 0.253521 0.174648 0.433803 0.138028 0.608451 0.391549 0.307042 0.205634 0.174648 0.312676 0.380282 0.619718 0.177465 0.495775 0.185915 0.140845 0.68169 0.31831 0.824261 37898.885 0.060452 0.285311 0.559322 0.276836 0.090395 0.596045 0.403955 0.271186 0.132768 0.138418 5.312325 9.228814 NMV_1809 2192771 CDS +2 1742906 1743229 324 validated/Curated no hisE phosphoribosyl-ATP pyrophosphatase (PRA-PH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.16 : Histidine ; 3.6.1.31 HISTPRATPHYD-RXN HISTSYN-PWY 2018-01-24 18:23:02 no Catalyses the second step in the histidine biosynthetic pathway: 1-(5-phosphoribosyl)-ATP + H(2)O <=> 1-(5-phosphoribosyl)-AMP + diphosphate. 2 vladimir 0.29321 0.2716 0.234568 0.200617 0.506173 0.493827 0.222222 0.222222 0.37037 0.185185 0.592593 0.407407 0.37037 0.25 0.101852 0.277778 0.351852 0.648148 0.287037 0.342593 0.231481 0.138889 0.574074 0.425926 0.656769 11895.06 -0.365421 0.280374 0.448598 0.242991 0.084112 0.476636 0.523364 0.327103 0.168224 0.158879 5.680183 8.672897 NMV_1810 2192772 CDS +1 1743301 1743624 324 validated/Curated no putative HitA-like protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-24 18:23:25 no Belongs to the HIT superfamily of proteins that are nucleotide-binding proteins containing a Histidine Triad (HIT) motif, His-phi-His-phi-His-phi-phi (phi being a hydrophobic amino acid). 2 vladimir 0.280864 0.2932 0.225309 0.200617 0.518519 0.481481 0.277778 0.240741 0.361111 0.12037 0.601852 0.398148 0.324074 0.231481 0.111111 0.333333 0.342593 0.657407 0.240741 0.407407 0.203704 0.148148 0.611111 0.388889 0.721621 11537.11 0.207477 0.271028 0.495327 0.242991 0.121495 0.64486 0.35514 0.252336 0.149533 0.102804 6.377556 8.990654 NMV_1811 2192773 CDS +2 1743671 1743874 204 validated/Curated no tatA sec-independent protein translocase TatA component 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.2.A.64 : The Type V Secretory Pathway or Twin Arginine Targeting (Tat) Family ; 2020-04-21 16:07:22 no Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. 1 vladimir 0.338235 0.2206 0.25 0.191176 0.470588 0.529412 0.323529 0.161765 0.411765 0.102941 0.573529 0.426471 0.411765 0.102941 0.161765 0.323529 0.264706 0.735294 0.279412 0.397059 0.176471 0.147059 0.573529 0.426471 0.753674 7404.16 -0.280597 0.238806 0.462687 0.268657 0.104478 0.507463 0.492537 0.358209 0.19403 0.164179 6.309303 8.029851 NMV_1812 2192774 CDS +2 1743878 1744564 687 validated/Curated no tatB sec-independent protein translocase TatB component 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 2 : Cytoplasmic 4.2.A.64 : The Type V Secretory Pathway or Twin Arginine Targeting (Tat) Family ; 2020-04-22 14:00:01 no Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. 2 vladimir 0.244541 0.3086 0.256186 0.190684 0.564774 0.435226 0.231441 0.257642 0.39738 0.113537 0.655022 0.344978 0.305677 0.279476 0.179039 0.235808 0.458515 0.541485 0.196507 0.388646 0.19214 0.222707 0.580786 0.419214 0.663307 25097.265 -0.571053 0.302632 0.526316 0.192982 0.061404 0.495614 0.504386 0.307018 0.144737 0.162281 5.194191 9.596491 NMV_1813 2192775 CDS +3 1744578 1745348 771 validated/Curated no tatC sec-independent protein translocase TatC component 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.2.A.64 : The Type V Secretory Pathway or Twin Arginine Targeting (Tat) Family ; 2020-04-22 13:58:11 no Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. 2 vladimir 0.212711 0.3061 0.210117 0.271077 0.516213 0.483787 0.256809 0.252918 0.307393 0.182879 0.560311 0.439689 0.18677 0.264591 0.108949 0.439689 0.373541 0.626459 0.194553 0.400778 0.214008 0.190661 0.614786 0.385214 0.637327 28524.005 0.816797 0.25 0.488281 0.320312 0.136719 0.691406 0.308594 0.132812 0.066406 0.066406 5.6632 8.671875 NMV_1814 2192776 CDS +1 1745401 1746009 609 validated/Curated no dTTP/UTP pyrophosphatase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 3.6.1.9 NUCLEOTIDE-PYROPHOSPHATASE-RXN$RXN0-4401 2020-04-21 16:14:11 no 25658941 Catalyses the following reaction: nucleoside triphosphate + H(2)O <=> a nucleotide + diphosphate. 2 vladimir 0.262726 0.3021 0.223317 0.211823 0.525452 0.474548 0.280788 0.216749 0.315271 0.187192 0.53202 0.46798 0.285714 0.241379 0.182266 0.29064 0.423645 0.576355 0.221675 0.448276 0.172414 0.157635 0.62069 0.37931 0.670575 22191.555 -0.163861 0.311881 0.514851 0.232673 0.079208 0.544554 0.455446 0.207921 0.108911 0.09901 7.207909 9.514851 NMV_1816 2192778 CDS +3 1746018 1746371 354 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 11:31:41 no 2 vladimir 0.217514 0.3164 0.200565 0.265537 0.516949 0.483051 0.254237 0.254237 0.220339 0.271186 0.474576 0.525424 0.211864 0.262712 0.144068 0.381356 0.40678 0.59322 0.186441 0.432203 0.237288 0.144068 0.669492 0.330508 0.624111 13234.35 0.717949 0.299145 0.418803 0.307692 0.145299 0.675214 0.324786 0.128205 0.08547 0.042735 9.273003 8.059829 NMV_1817 2192779 CDS +1 1746361 1748175 1815 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-05-01 11:31:28 no 2 vladimir 0.218733 0.3455 0.214325 0.221488 0.55978 0.44022 0.256198 0.26281 0.282645 0.198347 0.545455 0.454545 0.231405 0.276033 0.147107 0.345455 0.42314 0.57686 0.168595 0.497521 0.213223 0.120661 0.710744 0.289256 0.615955 67093.385 0.440894 0.309603 0.466887 0.259934 0.147351 0.662252 0.337748 0.153974 0.096026 0.057947 9.039406 8.759934 NMV_1818 2192780 CDS +1 1748365 1749042 678 validated/Curated no putative two-component system transcriptional regulator protein 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 3.1.2 : Transcriptional level ; 2020-02-20 14:16:19 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. 2 vladimir 0.261062 0.3201 0.246313 0.172566 0.566372 0.433628 0.274336 0.252212 0.367257 0.106195 0.619469 0.380531 0.29646 0.176991 0.185841 0.340708 0.362832 0.637168 0.212389 0.530973 0.185841 0.070796 0.716814 0.283186 0.719259 24778.57 -0.046667 0.253333 0.515556 0.293333 0.053333 0.537778 0.462222 0.271111 0.133333 0.137778 5.443382 9.173333 NMV_1819 2192781 CDS +2 1749056 1750462 1407 validated/Curated no putative two-component system sensor protein 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2.7.13.3 2.7.13.3-RXN 2018-01-22 20:09:13 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. 2 vladimir 0.276475 0.3149 0.221748 0.186923 0.536603 0.463397 0.30064 0.266525 0.30064 0.132196 0.567164 0.432836 0.321962 0.198294 0.164179 0.315565 0.362473 0.637527 0.206823 0.479744 0.200426 0.113006 0.680171 0.319829 0.657419 52779.755 -0.175214 0.254274 0.435897 0.252137 0.104701 0.534188 0.465812 0.260684 0.143162 0.117521 6.760262 9.066239 NMV_1820 2192782 CDS +2 1750580 1753006 2427 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-24 18:25:46 no Contains a domain found in Gcn5-related histone acetyltransferases (GNATs). 2 vladimir 0.278533 0.3931 0.182942 0.145447 0.57602 0.42398 0.311496 0.327565 0.262052 0.098888 0.589617 0.410383 0.304079 0.302843 0.15204 0.241038 0.454883 0.545117 0.220025 0.548826 0.134734 0.096415 0.68356 0.31644 0.623556 89151.245 -0.353589 0.330446 0.512376 0.201733 0.108911 0.502475 0.497525 0.241337 0.154703 0.086634 9.072838 9.155941 NMV_1821 2192783 CDS +1 1753051 1753296 246 validated/Curated no rpsP 30S ribosomal protein S16 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 18:26:06 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.272358 0.3293 0.231707 0.166667 0.560976 0.439024 0.231707 0.268293 0.365854 0.134146 0.634146 0.365854 0.329268 0.170732 0.231707 0.268293 0.402439 0.597561 0.256098 0.548781 0.097561 0.097561 0.646341 0.353659 0.842428 9291.24 -0.593827 0.234568 0.481481 0.222222 0.098765 0.493827 0.506173 0.320988 0.222222 0.098765 10.892159 10.148148 NMV_1822 2192784 CDS +1 1753312 1753821 510 validated/Curated no rimM ribosome maturation factor RimM 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 6.6 : Ribosome ; 2020-02-20 17:14:25 no Accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. 2 vladimir 0.3 0.2569 0.241176 0.201961 0.498039 0.501961 0.317647 0.117647 0.388235 0.176471 0.505882 0.494118 0.347059 0.176471 0.170588 0.305882 0.347059 0.652941 0.235294 0.476471 0.164706 0.123529 0.641176 0.358824 0.704619 18916.62 -0.164497 0.272189 0.508876 0.248521 0.118343 0.544379 0.455621 0.260355 0.100592 0.159763 4.485603 9.360947 NMV_1823 2192785 CDS +3 1753821 1754570 750 validated/Curated no trmD tRNA (guanine-N(1)-)-methyltransferase (M1G-methyltransferase; tRNA [GM37] methyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.228 RXN-12458 2018-01-19 10:30:42 no Specifically methylates guanosine-37 in various tRNAs. 2 vladimir 0.265333 0.2760 0.254667 0.204 0.530667 0.469333 0.228 0.272 0.34 0.16 0.612 0.388 0.284 0.216 0.192 0.308 0.408 0.592 0.284 0.34 0.232 0.144 0.572 0.428 0.585157 27811.03 -0.215261 0.257028 0.441767 0.236948 0.084337 0.570281 0.429719 0.26506 0.13253 0.13253 5.587364 9.630522 NMV_1824 2192786 CDS +3 1754586 1754951 366 validated/Curated no rplS 50S ribosomal protein L19 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-24 18:27:08 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.273224 0.2951 0.248634 0.18306 0.543716 0.456284 0.254098 0.286885 0.368852 0.090164 0.655738 0.344262 0.303279 0.163934 0.245902 0.286885 0.409836 0.590164 0.262295 0.434426 0.131148 0.172131 0.565574 0.434426 0.858319 13767.42 -0.509917 0.239669 0.438017 0.256198 0.057851 0.504132 0.495868 0.322314 0.206612 0.115702 10.445152 10.14876 NMV_1826 2192788 CDS +2 1755242 1755997 756 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2008-05-01 11:29:15 no 2 vladimir 0.248677 0.2950 0.23545 0.220899 0.530423 0.469577 0.234127 0.285714 0.31746 0.162698 0.603175 0.396825 0.293651 0.206349 0.190476 0.309524 0.396825 0.603175 0.218254 0.392857 0.198413 0.190476 0.59127 0.40873 0.62754 28322.54 -0.115936 0.278884 0.446215 0.227092 0.119522 0.561753 0.438247 0.23506 0.135458 0.099602 7.776039 9.561753 NMV_1828 2192790 CDS +3 1756032 1756907 876 validated/Curated no putative ABC transporter permease protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:28:23 no 2 vladimir 0.164384 0.3630 0.22831 0.244292 0.591324 0.408676 0.226027 0.284247 0.335616 0.15411 0.619863 0.380137 0.143836 0.215753 0.191781 0.44863 0.407534 0.592466 0.123288 0.589041 0.157534 0.130137 0.746575 0.253425 0.579475 30753.84 1.128179 0.33677 0.505155 0.357388 0.109966 0.735395 0.264605 0.120275 0.079038 0.041237 8.692909 8.037801 NMV_1830 2192792 CDS +1 1756984 1757898 915 validated/Curated no putative ABC transporter substrate-binding protein 3 : Putative function from multiple computational evidences t : transporter 9 : Periplasmic 2008-05-01 11:28:07 no 2 vladimir 0.301639 0.3224 0.210929 0.165027 0.533333 0.466667 0.285246 0.236066 0.377049 0.101639 0.613115 0.386885 0.377049 0.229508 0.144262 0.24918 0.37377 0.62623 0.242623 0.501639 0.111475 0.144262 0.613115 0.386885 0.704889 33278.415 -0.384868 0.302632 0.496711 0.203947 0.118421 0.523026 0.476974 0.286184 0.177632 0.108553 8.785728 9.141447 NMV_1831 2192793 CDS -2 1758178 1761393 3216 validated/Curated no FrpA/C protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 10 : Secreted 2018-01-24 18:27:48 no Is homologous to the iron-regulated FrpA/C proteins, which are related to the RTX family of exoproteins. 3 vladimir 0.289801 0.2071 0.252177 0.250933 0.459266 0.540734 0.26959 0.140858 0.405784 0.183769 0.546642 0.453358 0.360075 0.219216 0.183769 0.23694 0.402985 0.597015 0.239739 0.261194 0.166978 0.33209 0.428172 0.571828 0.608771 115624.4 -0.426611 0.345472 0.563959 0.18394 0.10831 0.524743 0.475257 0.236228 0.103641 0.132586 4.752846 9.314659 NMV_1832 2192794 CDS -1 1761410 1761916 507 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 11:27:36 no 3 vladimir 0.335306 0.0809 0.13215 0.451677 0.213018 0.786982 0.378698 0.112426 0.153846 0.35503 0.266272 0.733728 0.319527 0.076923 0.112426 0.491124 0.189349 0.810651 0.307692 0.053254 0.130178 0.508876 0.183432 0.816568 0.427961 20296.755 0.718452 0.142857 0.315476 0.309524 0.238095 0.678571 0.321429 0.154762 0.107143 0.047619 9.253777 8.52381 NMV_1833 2192795 CDS -1 1761950 1762399 450 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:27:25 no 3 vladimir 0.395556 0.1400 0.202222 0.262222 0.342222 0.657778 0.4 0.126667 0.3 0.173333 0.426667 0.573333 0.446667 0.213333 0.126667 0.213333 0.34 0.66 0.34 0.08 0.18 0.4 0.26 0.74 0.509516 16766.07 -0.879866 0.288591 0.469799 0.147651 0.100671 0.409396 0.590604 0.295302 0.187919 0.107383 9.696404 9.060403 NMV_1834 2192796 CDS -3 1762449 1762955 507 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-19 17:25:17 no 3 vladimir 0.293103 0.1322 0.162835 0.411877 0.295019 0.704981 0.327586 0.114943 0.183908 0.373563 0.298851 0.701149 0.275862 0.132184 0.16092 0.431034 0.293103 0.706897 0.275862 0.149425 0.143678 0.431034 0.293103 0.706897 0.485027 20750.2 0.503468 0.196532 0.352601 0.271676 0.213873 0.66474 0.33526 0.190751 0.132948 0.057803 9.41346 8.930636 NMV_1838 2192800 CDS +1 1763695 1764363 669 validated/Curated no IS1016 group transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-05-01 11:25:35 no 1 vladimir 0.285501 0.2287 0.233184 0.252616 0.461883 0.538117 0.300448 0.210762 0.313901 0.174888 0.524664 0.475336 0.345291 0.170404 0.183857 0.300448 0.35426 0.64574 0.210762 0.304933 0.201794 0.282511 0.506726 0.493274 0.61952 25328.025 -0.384234 0.238739 0.454955 0.22973 0.135135 0.509009 0.490991 0.306306 0.189189 0.117117 9.540031 8.986486 NMNmiscRNA0176 54921368 misc_RNA -1 1764949 1765066 118 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 14:04:46 28334889 Function unknown but has one paralog. vladimir NMNmiscRNA0177 54921369 misc_RNA -1 1765302 1765419 118 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 14:09:19 28334889 Function unknown but has one paralog. vladimir NMV_1839 2192801 CDS +3 1765650 1766192 543 validated/Curated no putative peptidase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-24 18:29:07 no Is homologous to the iron-regulated FrpA/C proteins, which are related to the RTX family of exoproteins. 1 vladimir 0.232044 0.1897 0.320442 0.257827 0.510129 0.489871 0.226519 0.198895 0.359116 0.21547 0.558011 0.441989 0.331492 0.198895 0.187845 0.281768 0.38674 0.61326 0.138122 0.171271 0.414365 0.276243 0.585635 0.414365 0.540868 20438.505 -0.408333 0.261111 0.472222 0.2 0.122222 0.533333 0.466667 0.283333 0.155556 0.127778 8.950005 9.127778 NMV_1840 2192802 CDS +3 1766322 1767983 1662 validated/Curated no etfdH electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO; ETF-ubiquinone oxidoreductase; ETF dehydrogenase; electron-transferring-flavoprotein dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.5.5.1 1.5.5.1-RXN 2018-01-24 18:31:02 no Catalyses the following reaction: reduced electron-transferring flavoprotein + ubiquinone <=> electron-transferring flavoprotein + ubiquinol. 1 vladimir 0.250903 0.2726 0.27497 0.201564 0.547533 0.452467 0.243682 0.212996 0.368231 0.17509 0.581227 0.418773 0.344765 0.212996 0.180505 0.261733 0.393502 0.606498 0.16426 0.391697 0.276173 0.16787 0.66787 0.33213 0.720312 61002.62 -0.340325 0.287523 0.508137 0.200723 0.119349 0.566004 0.433996 0.242315 0.119349 0.122966 5.439323 9.491863 NMV_1841 2192803 CDS -2 1768222 1768716 495 validated/Curated no putative copper-binding lipoprotein NosL 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-24 18:36:57 no NosL may act as a metallochaperone involved in nitrous oxide reductase assembly. Specifically binds Cu+. 2 vladimir 0.276768 0.2444 0.252525 0.226263 0.49697 0.50303 0.315152 0.169697 0.351515 0.163636 0.521212 0.478788 0.351515 0.224242 0.163636 0.260606 0.387879 0.612121 0.163636 0.339394 0.242424 0.254545 0.581818 0.418182 0.694461 18139.965 -0.403659 0.280488 0.530488 0.164634 0.121951 0.567073 0.432927 0.25 0.128049 0.121951 6.156563 9.164634 NMV_1842 2192804 CDS -2 1768933 1769553 621 validated/Curated no putative ABC transporter ATP-binding protein NosF 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2020-04-20 20:03:27 no 1 vladimir 0.242704 0.2995 0.278034 0.179724 0.577573 0.422427 0.258065 0.285714 0.359447 0.096774 0.645161 0.354839 0.276498 0.239631 0.193548 0.290323 0.43318 0.56682 0.193548 0.373272 0.281106 0.152074 0.654378 0.345622 0.561464 23356.015 -0.191667 0.328704 0.49537 0.24537 0.069444 0.541667 0.458333 0.25463 0.157407 0.097222 9.650261 9.356481 NMV_1843 2192805 fCDS -2 1769611 1770696 1086 validated/Curated partial truncated ABC transporter binding protein NosD (C-terminal 80% of the protein) (pseudogene part 2) 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2018-01-24 18:38:47 no NosD is a copper-binding protein, which is thought to insert copper into the exported nitrous oxide (N(2)O) reductase apoenzyme. 2 vladimir 0.253223 0.2845 0.256906 0.205341 0.541436 0.458564 0.320442 0.179558 0.339779 0.160221 0.519337 0.480663 0.345304 0.19337 0.196133 0.265193 0.389503 0.610497 0.093923 0.480663 0.234807 0.190608 0.71547 0.28453 0.697067 39966.92 -0.38144 0.290859 0.559557 0.202216 0.121884 0.526316 0.473684 0.221607 0.116343 0.105263 5.93792 9.736842 NMV_1843.1 2662690 fCDS -2 1770697 1770834 138 validated/Curated partial truncated ABC transporter binding protein NosD (C-terminal 80% of the protein) (pseudogene part 1) 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2018-01-24 18:38:52 NosD is a copper-binding protein, which is thought to insert copper into the exported nitrous oxide (N(2)O) reductase apoenzyme. vladimir NMV_1844 2192806 CDS -3 1770846 1771220 375 validated/Curated partial truncated regulatory protein NosR (N-terminal 20% of the protein) 3 : Putative function from multiple computational evidences r : regulator 1 : Unknown 2018-01-24 18:40:19 no NosR is a nitrous oxide reductase expression regulator. 1 vladimir 0.228621 0.2443 0.279232 0.247818 0.52356 0.47644 0.287958 0.219895 0.298429 0.193717 0.518325 0.481675 0.219895 0.298429 0.162304 0.319372 0.460733 0.539267 0.17801 0.21466 0.376963 0.230366 0.591623 0.408377 0.473925 20683.535 0.177368 0.321053 0.510526 0.242105 0.105263 0.621053 0.378947 0.205263 0.142105 0.063158 10.046425 8.794737 NMV_1845 2192807 CDS -3 1771548 1772795 1248 validated/Curated no hemA glutamyl-tRNA reductase (GluTR) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 1.2.1.70 GLUTRNAREDUCT-RXN PWY-5188 2018-01-24 18:41:00 no Catalyses the initial step in the C5 pathway that leads to delta-aminolevulinic acid (ALA), the obligatory precursor for the synthesis of all tetrapyrroles including porphyrin derivatives such as heme: L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) <=> L-glutamyl-tRNA(Glu) + NADPH. 1 vladimir 0.233173 0.2500 0.292468 0.224359 0.542468 0.457532 0.242788 0.21875 0.396635 0.141827 0.615385 0.384615 0.322115 0.242788 0.134615 0.300481 0.377404 0.622596 0.134615 0.288462 0.346154 0.230769 0.634615 0.365385 0.59752 45478.48 -0.083133 0.289157 0.498795 0.250602 0.062651 0.546988 0.453012 0.260241 0.127711 0.13253 5.472755 9.46988 NMV_1846 2192808 CDS -1 1772942 1773328 387 validated/Curated no gcvH glycine cleavage system H protein 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.1.3.5 : Glycine cleavage ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; GCVMULTI-RXN$GCVP-RXN$GCVT-RXN$RXN-8629 1CMET2-PWY$GLYCINE-SYN2-PWY$GLYCLEAV-PWY$PWY-2201 2018-01-30 13:42:51 no Is part of the glycine cleavage multienzyme complex (GCV), which catalyses the catabolism of glycine. 2 vladimir 0.255814 0.2894 0.273902 0.180879 0.563307 0.436693 0.209302 0.170543 0.496124 0.124031 0.666667 0.333333 0.348837 0.255814 0.131783 0.263566 0.387597 0.612403 0.209302 0.44186 0.193798 0.155039 0.635659 0.364341 0.800149 13652.565 -0.064844 0.304688 0.578125 0.234375 0.101562 0.601562 0.398438 0.242188 0.0625 0.179688 4.044579 9.679688 NMV_1847 2192809 CDS -2 1773436 1774425 990 validated/Curated no putative O-glucosyltransferase LpsA 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.6.3 : Lipopolysaccharide ; 2.4.1.- 2020-02-21 10:28:44 no 7539688 Might be involved in lipooligosaccharide core biosynthesis. 2 vladimir 0.264228 0.1809 0.222561 0.332317 0.403455 0.596545 0.216463 0.20122 0.286585 0.295732 0.487805 0.512195 0.368902 0.210366 0.143293 0.277439 0.353659 0.646341 0.207317 0.131098 0.237805 0.423781 0.368902 0.631098 0.587118 38355.34 -0.434862 0.2263 0.452599 0.189602 0.192661 0.535168 0.464832 0.29052 0.168196 0.122324 8.088463 9.455657 NMV_1848 2192810 CDS -1 1774511 1775611 1101 validated/Curated no gcvT glycine cleavage system T protein (aminomethyltransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.5 : Glycine cleavage ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 2.1.2.10 GCVMULTI-RXN$GCVP-RXN$GCVT-RXN$RXN-8629 1CMET2-PWY$GLYCINE-SYN2-PWY$GLYCLEAV-PWY$PWY-2201 2018-01-30 13:42:21 no Is part of the glycine cleavage multienzyme complex (GCV), which catalyses the catabolism of glycine. 2 vladimir 0.252498 0.2925 0.260672 0.194369 0.553134 0.446866 0.231608 0.201635 0.435967 0.13079 0.637602 0.362398 0.318801 0.217984 0.168937 0.294278 0.386921 0.613079 0.207084 0.457766 0.177112 0.158038 0.634877 0.365123 0.781393 39639.545 -0.153005 0.303279 0.538251 0.218579 0.101093 0.576503 0.423497 0.26776 0.136612 0.131148 5.816261 9.251366 NMNmiscRNA0179 54921371 misc_RNA -1 1775811 1775914 104 validated/Curated no glycine riboswitch 2a : Function from experimental evidences in other organisms 2018-01-29 14:19:10 28334889 The bacterial glycine riboswitch is an RNA element that can bind the amino acid glycine. It is thought that when glycine is in excess it will bind to both aptamers to activate these genes and facilitate glycine degradation. vladimir NMV_1850 2192812 CDS +3 1776123 1776605 483 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-24 18:44:05 no Belongs to the AsnC/Lrp subfamily of bacterial transcription regulation proteins, which bind DNA through a 'helix-turn-helix' motif. 2 vladimir 0.238095 0.2961 0.227743 0.238095 0.52381 0.47619 0.21118 0.298137 0.298137 0.192547 0.596273 0.403727 0.310559 0.242236 0.118012 0.329193 0.360248 0.639752 0.192547 0.347826 0.267081 0.192547 0.614907 0.385093 0.62122 18017.095 -0.076875 0.2625 0.45625 0.26875 0.1 0.5125 0.4875 0.2625 0.14375 0.11875 6.590004 8.55625 NMV_1851 2192813 CDS +1 1776661 1777257 597 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2015-11-21 18:30:27 no 2 vladimir 0.293729 0.3053 0.194719 0.206271 0.5 0.5 0.29703 0.242574 0.326733 0.133663 0.569307 0.430693 0.351485 0.247525 0.113861 0.287129 0.361386 0.638614 0.232673 0.425743 0.143564 0.19802 0.569307 0.430693 0.706536 22428.58 -0.267164 0.253731 0.492537 0.218905 0.114428 0.532338 0.467662 0.268657 0.124378 0.144279 5.009514 9.238806 NMV_1852 2192814 CDS +3 1777254 1777613 360 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 11:22:16 no 2 vladimir 0.169444 0.2917 0.258333 0.280556 0.55 0.45 0.216667 0.266667 0.216667 0.3 0.483333 0.516667 0.133333 0.25 0.25 0.366667 0.5 0.5 0.158333 0.358333 0.308333 0.175 0.666667 0.333333 0.620562 13808.13 0.555462 0.285714 0.428571 0.252101 0.184874 0.705882 0.294118 0.151261 0.134454 0.016807 10.526009 9.319328 NMV_1853 2192815 CDS +2 1777973 1779394 1422 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 11:22:03 no 2 vladimir 0.197609 0.3059 0.229958 0.266526 0.535865 0.464135 0.251055 0.240506 0.310127 0.198312 0.550633 0.449367 0.187764 0.244726 0.14135 0.42616 0.386076 0.613924 0.154008 0.432489 0.238397 0.175105 0.670886 0.329114 0.693759 51706.42 0.800634 0.293869 0.479915 0.295983 0.160677 0.708245 0.291755 0.131078 0.082452 0.048626 8.65905 8.346723 NMV_1854 2192816 CDS +1 1779742 1781085 1344 validated/Curated no nqrA Na(+)-translocating NADH-quinone reductase subunit A (Na(+)-translocating NQR subunit A; Na(+)-NQR subunit A; NQR complex subunit A; NQR-1 subunit A) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 7.2.1.1 TRANS-RXN-214 2020-04-21 13:20:32 no Generates an electrochemical Na+ potential driven by aerobic respiration. 1 vladimir 0.237351 0.2716 0.276042 0.21503 0.547619 0.452381 0.254464 0.198661 0.397321 0.149554 0.595982 0.404018 0.290179 0.225446 0.183036 0.301339 0.408482 0.591518 0.167411 0.390625 0.247768 0.194196 0.638393 0.361607 0.727177 48642.99 -0.08255 0.288591 0.516779 0.255034 0.082774 0.579418 0.420582 0.261745 0.136465 0.12528 6.212852 9.447427 NMV_1855 2192817 CDS +3 1781088 1782320 1233 validated/Curated no nqrB Na(+)-translocating NADH-quinone reductase subunit B (Na(+)-translocating NQR subunit B; Na(+)-NQR subunit B; NQR complex subunit B; NQR-1 subunit B) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 1 : Unknown 7.2.1.1 TRANS-RXN-214 2020-04-21 13:20:48 no Generates an electrochemical Na+ potential driven by aerobic respiration. 1 vladimir 0.187348 0.2758 0.280616 0.256285 0.556367 0.443633 0.245742 0.155718 0.374696 0.223844 0.530414 0.469586 0.201946 0.265207 0.170316 0.36253 0.435523 0.564477 0.114355 0.406326 0.296837 0.182482 0.703163 0.296837 0.78012 44525.365 0.59561 0.339024 0.519512 0.236585 0.165854 0.714634 0.285366 0.139024 0.082927 0.056098 8.787544 9.070732 NMV_1856 2192818 CDS +1 1782313 1783089 777 validated/Curated no nqrC Na(+)-translocating NADH-quinone reductase subunit C (Na(+)-translocating NQR subunit C; Na(+)-NQR subunit C; NQR complex subunit C; NQR-1 subunit C) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 11 : Membrane 7.2.1.1 TRANS-RXN-214 2020-04-21 13:21:04 no Generates an electrochemical Na+ potential driven by aerobic respiration. 2 vladimir 0.277992 0.2587 0.266409 0.196911 0.525097 0.474903 0.27027 0.158301 0.405405 0.166023 0.563707 0.436293 0.34749 0.185328 0.189189 0.277992 0.374517 0.625483 0.216216 0.432432 0.204633 0.146718 0.637066 0.362934 0.791204 27630.365 -0.179457 0.313953 0.515504 0.228682 0.096899 0.585271 0.414729 0.24031 0.127907 0.112403 7.87751 8.476744 NMV_1857 2192819 CDS +3 1783089 1783715 627 validated/Curated no nqrD Na(+)-translocating NADH-quinone reductase subunit D (Na(+)-translocating NQR subunit D; Na(+)-NQR subunit D; NQR complex subunit D; NQR-1 subunit D) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 11 : Membrane 7.2.1.1 TRANS-RXN-214 2020-04-21 13:21:30 no Generates an electrochemical Na+ potential driven by aerobic respiration. 2 vladimir 0.204147 0.2775 0.256778 0.261563 0.53429 0.46571 0.282297 0.196172 0.315789 0.205742 0.511962 0.488038 0.210526 0.215311 0.157895 0.416268 0.373206 0.626794 0.119617 0.421053 0.296651 0.162679 0.717703 0.282297 0.724653 22699.035 0.726923 0.298077 0.471154 0.3125 0.105769 0.673077 0.326923 0.129808 0.067308 0.0625 6.869957 8.610577 NMV_1858 2192820 CDS +3 1783719 1784312 594 validated/Curated no nqrE Na(+)-translocating NADH-quinone reductase subunit E (Na(+)-translocating NQR subunit E; Na(+)-NQR subunit E; NQR complex subunit E; NQR-1 subunit E) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 11 : Membrane 7.2.1.1 TRANS-RXN-214 2020-04-21 13:21:50 no Generates an electrochemical Na+ potential driven by aerobic respiration. 1 vladimir 0.193603 0.2475 0.259259 0.299663 0.506734 0.493266 0.247475 0.111111 0.358586 0.282828 0.469697 0.530303 0.19697 0.217172 0.126263 0.459596 0.343434 0.656566 0.136364 0.414141 0.292929 0.156566 0.707071 0.292929 0.743371 21206.59 1.085279 0.314721 0.477157 0.314721 0.142132 0.741117 0.258883 0.116751 0.060914 0.055838 6.773293 8.258883 NMV_1859 2192821 CDS +1 1784326 1785543 1218 validated/Curated no nqrF Na(+)-translocating NADH-quinone reductase subunit F (Na(+)-translocating NQR subunit F; Na(+)-NQR subunit F; NQR complex subunit F; NQR-1 subunit F) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 9 : Periplasmic 7.2.1.1 TRANS-RXN-214 2020-04-21 13:22:07 no Generates an electrochemical Na+ potential driven by aerobic respiration. 2 vladimir 0.256158 0.2808 0.25041 0.212644 0.531199 0.468801 0.261084 0.182266 0.366995 0.189655 0.549261 0.450739 0.325123 0.204434 0.165025 0.305419 0.369458 0.630542 0.182266 0.455665 0.219212 0.142857 0.674877 0.325123 0.791501 45220.1 -0.167407 0.254321 0.491358 0.219753 0.118519 0.587654 0.412346 0.266667 0.118519 0.148148 4.886574 9.516049 NMV_1860 2192822 CDS +3 1785696 1786751 1056 validated/Curated no apbE FAD:protein FMN transferase 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.5.3.8 : Thiamine (Vitamin B1) ; 2.7.1.180 2018-01-24 18:46:57 no Is involved in thiamine synthesis. Catalyses the following reaction: FAD + [protein]-L-threonine <=> [protein]-FMN-L-threonine + AMP. 2 vladimir 0.278409 0.3011 0.217803 0.202652 0.518939 0.481061 0.295455 0.227273 0.3125 0.164773 0.539773 0.460227 0.326705 0.241477 0.159091 0.272727 0.400568 0.599432 0.213068 0.434659 0.181818 0.170455 0.616477 0.383523 0.682688 38661.43 -0.35812 0.299145 0.501425 0.225071 0.094017 0.507123 0.492877 0.250712 0.145299 0.105413 9.057243 8.891738 NMV_1862 2192824 CDS +1 1786777 1786992 216 validated/Curated no conserved hypothetical membrane-associated protein 4 : Unknown function but conserved in other organisms u : unknown 6 : Inner membrane-associated 2008-05-01 11:20:06 no 1 vladimir 0.277778 0.2593 0.24537 0.217593 0.50463 0.49537 0.375 0.166667 0.305556 0.152778 0.472222 0.527778 0.263889 0.152778 0.25 0.333333 0.402778 0.597222 0.194444 0.458333 0.180556 0.166667 0.638889 0.361111 0.730468 7716.92 0.180282 0.352113 0.478873 0.239437 0.056338 0.591549 0.408451 0.253521 0.15493 0.098592 9.050301 8.887324 NMV_1863 2192825 CDS -2 1787116 1787694 579 validated/Curated no grpE protein GrpE (HSP-70 cofactor) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2020-04-22 13:54:25 no Dimeric GrpE is the co-chaperone for DnaK and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5,000-fold. 1 vladimir 0.276339 0.2176 0.333333 0.172712 0.55095 0.44905 0.248705 0.238342 0.430052 0.082902 0.668394 0.331606 0.42487 0.217617 0.103627 0.253886 0.321244 0.678756 0.15544 0.196891 0.466321 0.181347 0.663212 0.336788 0.61708 21321.015 -0.6 0.25 0.473958 0.192708 0.052083 0.479167 0.520833 0.286458 0.114583 0.171875 4.629478 10.140625 NMV_1864 2192826 CDS +1 1787878 1788696 819 validated/Curated no cysE serine acetyltransferase (SAT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.12 : Cysteine ; 2.3.1.30 SERINE-O-ACETTRAN-RXN CYSTSYN-PWY 2018-01-24 18:48:04 no Is involved in cysteine biosynthesis, by catalysing the following reaction: acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine. 2 vladimir 0.230769 0.3089 0.258852 0.201465 0.567766 0.432234 0.249084 0.21978 0.3663 0.164835 0.586081 0.413919 0.282051 0.230769 0.179487 0.307692 0.410256 0.589744 0.161172 0.47619 0.230769 0.131868 0.70696 0.29304 0.685189 29398.435 0.020956 0.319853 0.522059 0.238971 0.117647 0.584559 0.415441 0.235294 0.132353 0.102941 6.311119 9.047794 NMV_1865 2192827 CDS -3 1789053 1790564 1512 validated/Curated no putative protein kinase UbiB 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 2.7.-.- 2.7.11.13-RXN$PROTEIN-KINASE-RXN 2020-02-25 20:23:51 no Is probably a protein kinase regulator of UbiI activity, which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. 2 vladimir 0.219577 0.2784 0.269841 0.232143 0.54828 0.45172 0.222222 0.263889 0.329365 0.184524 0.593254 0.406746 0.297619 0.196429 0.160714 0.345238 0.357143 0.642857 0.138889 0.375 0.319444 0.166667 0.694444 0.305556 0.687057 57303.69 -0.000199 0.220676 0.437376 0.274354 0.111332 0.588469 0.411531 0.260437 0.143141 0.117296 8.656807 9.119284 NMV_1866 2192828 CDS -2 1790599 1791063 465 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:19:16 no 1 vladimir 0.251613 0.1957 0.303226 0.249462 0.498925 0.501075 0.193548 0.225806 0.387097 0.193548 0.612903 0.387097 0.374194 0.154839 0.180645 0.290323 0.335484 0.664516 0.187097 0.206452 0.341935 0.264516 0.548387 0.451613 0.546067 17588.295 -0.453896 0.207792 0.409091 0.24026 0.103896 0.558442 0.441558 0.331169 0.116883 0.214286 4.417351 9.935065 NMV_1867 2192829 CDS -2 1791223 1791561 339 validated/Curated no putative iron-sulfur cluster insertion protein ErpA 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-24 18:49:43 no Required for insertion of 4Fe-4S clusters. 1 vladimir 0.253687 0.1947 0.256637 0.294985 0.451327 0.548673 0.256637 0.097345 0.371681 0.274336 0.469027 0.530973 0.336283 0.176991 0.19469 0.292035 0.371681 0.628319 0.168142 0.309735 0.20354 0.318584 0.513274 0.486726 0.712146 12290.145 -0.129464 0.3125 0.571429 0.196429 0.116071 0.544643 0.455357 0.223214 0.053571 0.169643 3.919075 9.491071 NMV_1868 2192830 CDS -3 1791693 1792379 687 validated/Curated no putative transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-24 18:49:57 no Contains two domains: a lambda repressor-like DNA-binding domain and a MEROPS peptidase families S24/S26A/S26B domain. Is homologous to many repressor proteins, especially bacteriophage CI repressor proteins. 1 vladimir 0.270742 0.1674 0.294032 0.267831 0.461427 0.538574 0.31441 0.135371 0.366812 0.183406 0.502183 0.497817 0.331878 0.183406 0.179039 0.305677 0.362445 0.637555 0.165939 0.183406 0.336245 0.31441 0.519651 0.480349 0.554744 25783.225 -0.287281 0.241228 0.491228 0.241228 0.109649 0.535088 0.464912 0.285088 0.127193 0.157895 4.891701 9.473684 NMV_1869 2192831 CDS +1 1792567 1792839 273 validated/Curated no hypothetical membrane-associated protein 5 : Unknown function u : unknown 6 : Inner membrane-associated 2008-05-01 11:18:19 no 1 vladimir 0.32967 0.2674 0.186813 0.216117 0.454212 0.545788 0.274725 0.142857 0.32967 0.252747 0.472527 0.527473 0.428571 0.230769 0.087912 0.252747 0.318681 0.681319 0.285714 0.428571 0.142857 0.142857 0.571429 0.428571 0.732954 10284.155 -0.421111 0.288889 0.433333 0.166667 0.122222 0.488889 0.511111 0.277778 0.1 0.177778 4.450676 9.477778 NMV_1870 2192832 CDS +1 1793047 1794975 1929 validated/Curated no dnaK chaperone protein DnaK (heat shock protein 70; heat shock 70 kDa protein; HSP70) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2018-01-24 18:51:12 no DnaK is involved in chromosomal DNA replication, possibly through an interaction with the DnaA protein. 2 vladimir 0.310005 0.2711 0.24365 0.17522 0.514774 0.485226 0.287714 0.150855 0.446345 0.115086 0.597201 0.402799 0.368585 0.242613 0.135303 0.253499 0.377916 0.622084 0.273717 0.419907 0.1493 0.157076 0.569207 0.430793 0.872486 68888.765 -0.376168 0.314642 0.524922 0.208723 0.048287 0.510903 0.489097 0.305296 0.132399 0.172897 4.792259 9.084112 NMV_1871 2192833 CDS +2 1796009 1796980 972 validated/Curated no IS110 family transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-05-01 11:17:57 no 1 vladimir 0.279835 0.2809 0.248971 0.190329 0.529835 0.470165 0.314815 0.237654 0.324074 0.123457 0.561728 0.438272 0.324074 0.265432 0.141975 0.268519 0.407407 0.592593 0.200617 0.339506 0.280864 0.179012 0.62037 0.37963 0.621702 36191.26 -0.387307 0.294118 0.473684 0.204334 0.092879 0.495356 0.504644 0.287926 0.176471 0.111455 9.498482 9.501548 NMV_1872 2192834 fCDS +1 1797028 1797189 162 validated/Curated pseudo conserved hypothetical integral membrane protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-06-18 16:30:08 no 1 vladimir 0.148148 0.2546 0.277778 0.319444 0.532407 0.467593 0.166667 0.194444 0.388889 0.25 0.583333 0.416667 0.125 0.236111 0.152778 0.486111 0.388889 0.611111 0.152778 0.333333 0.291667 0.222222 0.625 0.375 0.575383 7641.91 1.316901 0.295775 0.521127 0.338028 0.169014 0.802817 0.197183 0.098592 0.056338 0.042254 6.754387 8.422535 NMV_1873 2192835 fCDS +2 1797224 1798102 879 validated/Curated pseudo conserved hypothetical integral membrane protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-06-18 16:30:21 no 2 vladimir 0.171786 0.3072 0.238908 0.282139 0.546075 0.453925 0.215017 0.259386 0.31058 0.215017 0.569966 0.430034 0.1843 0.279863 0.122867 0.412969 0.40273 0.59727 0.116041 0.382253 0.283276 0.21843 0.665529 0.334471 0.628805 32226.355 0.894863 0.30137 0.476027 0.311644 0.15411 0.715753 0.284247 0.133562 0.092466 0.041096 9.454582 8.667808 NMV_1874 2192836 CDS -1 1798148 1800337 2190 validated/Curated no priA primosomal protein N' (replication factor Y) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.6.4.- 2018-01-24 18:52:14 no Is a component of the primosome, which is involved in replication, repair and recombination. 1 vladimir 0.203653 0.2831 0.310502 0.20274 0.593607 0.406393 0.2 0.269863 0.358904 0.171233 0.628767 0.371233 0.291781 0.247945 0.176712 0.283562 0.424658 0.575342 0.119178 0.331507 0.39589 0.153425 0.727397 0.272603 0.627211 81240.88 -0.22524 0.279835 0.500686 0.21262 0.106996 0.566529 0.433471 0.246914 0.135802 0.111111 6.912788 9.731139 NMV_1875 2192837 CDS +2 1800476 1801258 783 validated/Curated no dsbC thiol:disulfide interchange lipoprotein DsbC 2a : Function from experimental evidences in other organisms f : factor 11 : Membrane 5.3.4.1-RXN$DISULFOXRED-RXN 2018-01-27 12:07:51 no Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD. 2 vladimir 0.257982 0.3129 0.243934 0.185185 0.556833 0.443167 0.298851 0.183908 0.344828 0.172414 0.528736 0.471264 0.306513 0.249042 0.172414 0.272031 0.421456 0.578544 0.168582 0.505747 0.214559 0.111111 0.720307 0.279693 0.766151 28544.765 -0.245769 0.303846 0.526923 0.203846 0.084615 0.553846 0.446154 0.25 0.134615 0.115385 8.508446 9.203846 NMV_1876 2192838 CDS -2 1801576 1803510 1935 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:16:43 no 2 vladimir 0.244961 0.2796 0.272868 0.202584 0.552455 0.447545 0.325581 0.162791 0.35969 0.151938 0.522481 0.477519 0.269767 0.221705 0.186047 0.322481 0.407752 0.592248 0.139535 0.454264 0.272868 0.133333 0.727132 0.272868 0.637699 69270.725 0.052484 0.329193 0.52795 0.253106 0.072981 0.555901 0.444099 0.226708 0.121118 0.10559 7.28289 8.902174 NMV_1877 2192839 CDS -3 1803576 1804754 1179 validated/Curated no putative membrane fusion protein 3 : Putative function from multiple computational evidences t : transporter 9 : Periplasmic 2018-01-27 12:08:56 no Belongs to the membrane fusion protein (MFP) family. MFP are proteins involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents. 1 vladimir 0.26039 0.2341 0.320611 0.184902 0.554707 0.445293 0.328244 0.147583 0.389313 0.13486 0.536896 0.463104 0.310433 0.29771 0.150127 0.24173 0.447837 0.552163 0.142494 0.256997 0.422392 0.178117 0.679389 0.320611 0.557641 41716.605 -0.274235 0.372449 0.561224 0.204082 0.045918 0.512755 0.487245 0.229592 0.119898 0.109694 8.890511 9.05102 NMV_1878 2192840 CDS +3 1804980 1805369 390 validated/Curated no pilV minor pilin PilV 1c : Function from experimental evidences in the studied genus s : structure 3 : Fimbrial 6.5 : Pilus ; 2020-04-25 14:37:47 no 11752467 Minor pilus subunit that assembles within the filaments in a similar way to PilE, but is not required for pilus biogenesis. It modulates pilus-mediated properties. 2 vladimir 0.289744 0.3385 0.187179 0.184615 0.525641 0.474359 0.369231 0.230769 0.246154 0.153846 0.476923 0.523077 0.346154 0.246154 0.138462 0.269231 0.384615 0.615385 0.153846 0.538462 0.176923 0.130769 0.715385 0.284615 0.681303 14544.11 -0.39845 0.302326 0.51938 0.209302 0.108527 0.488372 0.511628 0.217054 0.139535 0.077519 9.421043 9.457364 NMV_1879 2192841 CDS +3 1805652 1806698 1047 validated/Curated no adhA alcohol dehydrogenase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.1.1 ALCOHOL-DEHYDROG-GENERIC-RXN$ALCOHOL-DEHYDROG-RXN$R542-RXN$RXN-10781$RXN-10911$RXN-10915$RXN-12448$RXN-5424$RXN-5444$RXN-6021$RXN-7657$RXN-7693$RXN-7694$RXN-7700$RXN-7706$RXN3O-4113 FERMENTATION-PWY$PWY-5057$PWY-5751 2018-01-27 12:10:31 no Catalyses the following reactions: aprimary alcohol + NAD+ <=> an aldehyde + NADH or a secondary alcohol + NAD+ <=> a ketone + NADH. 1 vladimir 0.225744 0.2671 0.310279 0.196926 0.577329 0.42267 0.195965 0.149856 0.501441 0.152738 0.651297 0.348703 0.291066 0.213256 0.210375 0.285303 0.423631 0.576369 0.190202 0.43804 0.21902 0.152738 0.657061 0.342939 0.811 36348.955 0.109249 0.346821 0.598266 0.248555 0.078035 0.618497 0.381503 0.251445 0.124277 0.127168 5.444878 9.982659 NMV_1880 2192842 CDS -3 1806774 1810259 3486 validated/Curated no smc chromosome partition protein Smc 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 1.2.2 : DNA ; 2018-01-27 12:11:43 no SMC (structural maintenance of chromosomes) proteins bind DNA and act in organising and segregating chromosomes for partition. 2 vladimir 0.255307 0.3115 0.277108 0.156053 0.58864 0.41136 0.192771 0.319277 0.365749 0.122203 0.685026 0.314974 0.394148 0.239243 0.13167 0.23494 0.370912 0.629088 0.179002 0.376076 0.333907 0.111015 0.709983 0.290017 0.662508 130073.49 -0.587855 0.27907 0.42205 0.20155 0.079242 0.471146 0.528854 0.26615 0.128338 0.137812 5.287331 9.589147 NMV_1881 2192843 CDS +2 1810508 1811230 723 validated/Curated no lpxH UDP-2,3-diacylglucosamine hydrolase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.3.3 : Lipid A ; 3.6.1.54 LIPIDXSYNTHESIS-RXN KDO-NAGLIPASYN-PWY$NAGLIPASYN-PWY 2018-01-23 11:51:38 no Catalyses the fourth step in lipid A biosynthesis. This reaction involves pyrophosphate bond hydrolysis of the precursor UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate and UMP. 1 vladimir 0.208852 0.2725 0.279391 0.239281 0.551867 0.448133 0.215768 0.248963 0.3361 0.19917 0.585062 0.414938 0.282158 0.182573 0.211618 0.323651 0.394191 0.605809 0.128631 0.385892 0.290456 0.195021 0.676349 0.323651 0.62459 27552.905 -0.132083 0.254167 0.45 0.241667 0.141667 0.554167 0.445833 0.316667 0.195833 0.120833 9.198021 9.583333 NMV_1883 2192845 CDS +3 1811499 1813085 1587 validated/Curated no putative L-lactate permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 12:12:17 no Is an integral membrane protein probably involved in L-lactate transport. 2 vladimir 0.206049 0.2880 0.253308 0.252678 0.541273 0.458727 0.311909 0.170132 0.330813 0.187146 0.500945 0.499055 0.187146 0.255198 0.139887 0.417769 0.395085 0.604915 0.119093 0.438563 0.289225 0.153119 0.727788 0.272212 0.761909 56804.535 0.877083 0.316288 0.520833 0.299242 0.119318 0.710227 0.289773 0.109848 0.0625 0.047348 8.797157 8.435606 NMV_1884 2192846 CDS -3 1813254 1813457 204 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:15:03 no 1 vladimir 0.215686 0.2647 0.294118 0.22549 0.558824 0.441176 0.176471 0.294118 0.279412 0.25 0.573529 0.426471 0.352941 0.191176 0.235294 0.220588 0.426471 0.573529 0.117647 0.308824 0.367647 0.205882 0.676471 0.323529 0.62443 7571.22 -0.576119 0.253731 0.522388 0.179104 0.149254 0.58209 0.41791 0.238806 0.119403 0.119403 5.333473 10.820896 NMV_1885 2192847 CDS +1 1813573 1814070 498 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:14:52 no 2 vladimir 0.259036 0.3554 0.222892 0.162651 0.578313 0.421687 0.180723 0.277108 0.36747 0.174699 0.644578 0.355422 0.36747 0.253012 0.138554 0.240964 0.391566 0.608434 0.228916 0.536145 0.162651 0.072289 0.698795 0.301205 0.691064 18528.97 -0.375152 0.30303 0.454545 0.2 0.133333 0.527273 0.472727 0.272727 0.10303 0.169697 4.475136 9.218182 NMV_1887 2192849 CDS +1 1814152 1815345 1194 validated/Curated no aspC aspartate aminotransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.1.3.4 : Glutamate degradation ; 1.5.1.5 : Aspartate ; 2.6.1.1 2.6.1.7-RXN$ASPAMINOTRANS-RXN$CYSTEINE-AMINOTRANSFERASE-RXN$PHEAMINOTRANS-RXN$TYRAMINOTRANS-RXN ASPARTATE-DEG1-PWY$GLUTDEG-PWY$PHESYN$PWY-5913$PWY0-1534$TYRSYN 2020-04-21 16:19:26 no Catalyses the following reaction: 2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate. 2 vladimir 0.273869 0.2889 0.234506 0.20268 0.523451 0.476549 0.278894 0.183417 0.366834 0.170854 0.550251 0.449749 0.346734 0.223618 0.163317 0.266332 0.386935 0.613065 0.19598 0.459799 0.173367 0.170854 0.633166 0.366834 0.818148 44001.23 -0.28136 0.297229 0.483627 0.209068 0.11335 0.546599 0.453401 0.267003 0.13602 0.130982 5.802055 9.211587 NMV_1888 2192850 CDS -1 1815749 1816726 978 validated/Curated no hemC porphobilinogen deaminase (PBG; hydroxymethylbilane synthase; HMBS; pre-uroporphyrinogen synthase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 2.5.1.61 OHMETHYLBILANESYN-RXN PWY-5188 2018-01-27 12:13:36 no Is the third enzyme in the biosynthetic pathway of tetrapyrroles, which catalyses the following reaction: 4 porphobilinogen + H(2)O <=> hydroxymethylbilane + 4 NH(3). 1 vladimir 0.222222 0.2585 0.298077 0.221154 0.556624 0.443376 0.192308 0.211538 0.416667 0.179487 0.628205 0.371795 0.291667 0.240385 0.192308 0.275641 0.432692 0.567308 0.182692 0.323718 0.285256 0.208333 0.608974 0.391026 0.714221 33516.11 -0.12283 0.315113 0.508039 0.244373 0.064309 0.585209 0.414791 0.273312 0.141479 0.131833 6.033943 9.604502 NMV_1889 2192851 CDS +3 1816803 1817318 516 validated/Curated no putative endoribonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.-.- 2018-01-27 12:14:51 no Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts together with the RNase R to eliminate defective 70S ribosomes. 2 vladimir 0.277132 0.2907 0.226744 0.205426 0.517442 0.482558 0.203488 0.255814 0.343023 0.197674 0.598837 0.401163 0.401163 0.19186 0.151163 0.255814 0.343023 0.656977 0.226744 0.424419 0.186047 0.162791 0.610465 0.389535 0.760986 19972.76 -0.581871 0.222222 0.397661 0.192982 0.146199 0.520468 0.479532 0.321637 0.146199 0.175439 4.988365 10.233918 NMV_1890 2192852 CDS +1 1817320 1818144 825 validated/Curated no corC magnesium and cobalt efflux protein CorC 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2018-01-27 12:15:15 no Plays a role in the transport of magnesium and cobalt ions. 2 vladimir 0.247273 0.2897 0.252121 0.210909 0.541818 0.458182 0.243636 0.207273 0.392727 0.156364 0.6 0.4 0.341818 0.189091 0.149091 0.32 0.338182 0.661818 0.156364 0.472727 0.214545 0.156364 0.687273 0.312727 0.728995 31068.955 -0.294891 0.240876 0.448905 0.248175 0.10219 0.492701 0.507299 0.339416 0.145985 0.193431 4.766731 9.434307 NMV_1891 2192853 CDS -3 1818273 1819652 1380 validated/Curated no putative Na(+)/H(+) antiporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 12:15:43 no Na+/H+ antiporter. Involved in pH homeostasis and sodium extrusion. 1 vladimir 0.171014 0.2522 0.28913 0.287681 0.541304 0.458696 0.263043 0.178261 0.332609 0.226087 0.51087 0.48913 0.171739 0.241304 0.176087 0.41087 0.417391 0.582609 0.078261 0.336957 0.358696 0.226087 0.695652 0.304348 0.667608 49365.58 0.874728 0.348584 0.507625 0.291939 0.135076 0.71024 0.28976 0.11329 0.061002 0.052288 6.171837 8.590414 NMV_1892 2192854 CDS -1 1820096 1821319 1224 validated/Curated no putative glucose/galactose transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:13:27 no 1 vladimir 0.183007 0.2516 0.280229 0.285131 0.531863 0.468137 0.235294 0.169118 0.365196 0.230392 0.534314 0.465686 0.20098 0.27451 0.142157 0.382353 0.416667 0.583333 0.112745 0.311274 0.333333 0.242647 0.644608 0.355392 0.684848 43189.07 0.823833 0.366093 0.550369 0.275184 0.144963 0.710074 0.289926 0.105651 0.068796 0.036855 8.770348 8.702703 NMV_1893 2192855 CDS +3 1821909 1822316 408 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 11:13:13 no 2 vladimir 0.154412 0.3235 0.27451 0.247549 0.598039 0.401961 0.183824 0.264706 0.316176 0.235294 0.580882 0.419118 0.147059 0.308824 0.205882 0.338235 0.514706 0.485294 0.132353 0.397059 0.301471 0.169118 0.698529 0.301471 0.659846 14822.05 0.583704 0.362963 0.488889 0.222222 0.162963 0.748148 0.251852 0.118519 0.088889 0.02963 9.914085 9.288889 NMV_1894 2192856 CDS +3 1822362 1822991 630 validated/Curated no nth endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.2.2 : DNA ; 4.2.99.18 RXN0-2601 2018-01-27 12:16:57 no The spectrum of DNA damage caused by reactive oxygen species includes a wide variety of modifications of purine and pyrimidine bases. Among these modified bases, 7,8-dihydro-8-oxoguanine (8-oxoG) is an important mutagenic lesion. Endonuclease III has an 8-oxoG DNA glycosylase/AP lyase activity which removes 8-oxoG preferentially from 8-oxoG/G mispairs. 2 vladimir 0.268254 0.2889 0.249206 0.193651 0.538095 0.461905 0.285714 0.228571 0.314286 0.171429 0.542857 0.457143 0.32381 0.238095 0.138095 0.3 0.37619 0.62381 0.195238 0.4 0.295238 0.109524 0.695238 0.304762 0.682916 23643.64 -0.227751 0.253589 0.4689 0.22488 0.110048 0.545455 0.454545 0.287081 0.172249 0.114833 8.778786 9.717703 NMV_1895 2192857 CDS +2 1823129 1824628 1500 validated/Curated no putative periplasmic DegP-like serine endoprotease 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 3.4.21.107 3.4.21.107-RXN 2018-01-23 11:26:09 no Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. 2 vladimir 0.260667 0.3107 0.250667 0.178 0.561333 0.438667 0.272 0.196 0.404 0.128 0.6 0.4 0.29 0.232 0.192 0.286 0.424 0.576 0.22 0.504 0.156 0.12 0.66 0.34 0.710441 52574.35 -0.087375 0.336673 0.569138 0.230461 0.072144 0.573146 0.426854 0.218437 0.104208 0.114228 5.233177 8.805611 NMV_1896 2192858 CDS +1 1824829 1826349 1521 validated/Curated no putative Na+/H+ antiporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-05-01 11:12:33 no 2 vladimir 0.189349 0.3064 0.25378 0.250493 0.560158 0.439842 0.260355 0.18146 0.358974 0.199211 0.540434 0.459566 0.171598 0.29783 0.153846 0.376726 0.451677 0.548323 0.136095 0.439842 0.248521 0.175542 0.688363 0.311637 0.682509 53513.025 0.818182 0.379447 0.563241 0.288538 0.116601 0.683794 0.316206 0.134387 0.079051 0.055336 8.102562 8.490119 NMV_1897 2192859 CDS +3 1826406 1827491 1086 validated/Curated no nagZ beta-hexosaminidase (N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.2.1.52 3.2.1.52-RXN$RXN0-5226 2018-01-27 12:17:36 no Catalyses the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. 2 vladimir 0.213628 0.3177 0.267035 0.201657 0.584715 0.415285 0.196133 0.243094 0.41989 0.140884 0.662983 0.337017 0.265193 0.237569 0.198895 0.298343 0.436464 0.563536 0.179558 0.472376 0.18232 0.165746 0.654696 0.345304 0.66045 39006.14 -0.004155 0.313019 0.526316 0.221607 0.091413 0.606648 0.393352 0.249307 0.121884 0.127424 5.352806 9.66482 NMV_tRNA_30 2194845 tRNA +1 1827719 1827795 77 validated/Curated no Pro tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:57:54 no tRNA Pro anticodon CGG. vladimir NMV_1899 2192861 CDS -3 1828317 1828955 639 validated/Curated no queE 7-carboxy-7-deazaguanine synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 4.3.99.3 RXN0-6575 PWY-6703 2018-01-27 12:19:59 no Catalyses the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. 1 vladimir 0.262911 0.2895 0.244131 0.203443 0.533646 0.466354 0.295775 0.211268 0.323944 0.169014 0.535211 0.464789 0.328638 0.201878 0.197183 0.2723 0.399061 0.600939 0.164319 0.455399 0.211268 0.169014 0.666667 0.333333 0.692865 23740.375 -0.137736 0.287736 0.495283 0.212264 0.113208 0.59434 0.40566 0.231132 0.108491 0.122642 5.098061 10.122642 NMV_1900 2192862 CDS -1 1828952 1829323 372 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-05-01 11:11:01 no 2 vladimir 0.193548 0.2796 0.282258 0.244624 0.561828 0.438172 0.193548 0.217742 0.379032 0.209677 0.596774 0.403226 0.217742 0.241935 0.145161 0.395161 0.387097 0.612903 0.169355 0.379032 0.322581 0.129032 0.701613 0.298387 0.593458 13432.34 0.744715 0.300813 0.471545 0.276423 0.162602 0.731707 0.268293 0.130081 0.073171 0.056911 8.198265 8.593496 NMV_1901 2192863 CDS -3 1829592 1830014 423 validated/Curated no putative 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 4.1.2.50 RXN0-5507 PWY-6703 2020-04-21 16:29:02 no Catalyses the following reaction: 7,8-dihydroneopterin 3'-triphosphate + H(2)O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate. The reaction is part of the biosynthesis pathway of queuosine. 2 vladimir 0.276596 0.2908 0.255319 0.177305 0.546099 0.453901 0.297872 0.198582 0.333333 0.170213 0.531915 0.468085 0.361702 0.205674 0.170213 0.262411 0.375887 0.624113 0.170213 0.468085 0.262411 0.099291 0.730496 0.269504 0.690451 15802.365 -0.478571 0.285714 0.492857 0.178571 0.128571 0.514286 0.485714 0.307143 0.164286 0.142857 5.95298 9.95 NMV_1902 2192864 CDS -3 1830021 1830539 519 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:10:29 no 2 vladimir 0.242775 0.3198 0.248555 0.188825 0.568401 0.431599 0.219653 0.248555 0.381503 0.150289 0.630058 0.369942 0.352601 0.242775 0.150289 0.254335 0.393064 0.606936 0.156069 0.468208 0.213873 0.16185 0.682081 0.317919 0.714109 19042.785 -0.295349 0.27907 0.5 0.19186 0.151163 0.593023 0.406977 0.261628 0.139535 0.122093 5.864861 9.412791 NMV_1903 2192865 CDS -3 1830567 1831226 660 validated/Curated no queC 7-cyano-7-deazaguanine synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.3.4.20 RXN-12093 PWY-6703 2018-01-27 14:18:02 no 16199558 Catalyses the following reaction: 7-carboxy-7-carbaguanine + NH(3) + ATP <=> 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O. 2 vladimir 0.239394 0.2909 0.268182 0.201515 0.559091 0.440909 0.263636 0.222727 0.345455 0.168182 0.568182 0.431818 0.318182 0.209091 0.186364 0.286364 0.395455 0.604545 0.136364 0.440909 0.272727 0.15 0.713636 0.286364 0.703415 24386.88 -0.061644 0.315068 0.493151 0.223744 0.109589 0.56621 0.43379 0.219178 0.105023 0.114155 5.19622 10.018265 NMV_misc_RNA_4 2194963 misc_RNA -1 1831229 1831274 46 validated/Curated no putative PreQ1 riboswitch 3 : Putative function from multiple computational evidences n : RNA 2 : Cytoplasmic 2018-01-28 18:43:15 The PreQ1-I riboswitch is a cis-acting element identified in bacteria which regulates expression of genes involved in biosynthesis of the nucleoside queuosine from GTP. This RNA element binds preQ1 (pre-queuosine1), an intemediate in the queuosine pathway. vladimir NMV_1904 2192866 CDS +1 1831741 1832997 1257 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2018-01-22 20:36:51 no 1 vladimir 0.175224 0.2600 0.309698 0.255094 0.569682 0.430318 0.198044 0.229829 0.330073 0.242054 0.559902 0.440098 0.217604 0.244499 0.176039 0.361858 0.420538 0.579462 0.110024 0.305623 0.422983 0.161369 0.728606 0.271394 0.600714 46100.895 0.286029 0.286765 0.485294 0.25 0.142157 0.627451 0.372549 0.176471 0.098039 0.078431 9.110329 9.362745 NMV_1905 2192867 CDS -3 1833018 1833299 282 validated/Curated partial truncated putative bacteriocin/pheromone secretion/processing ATP-binding protein (C-terminal 13% of the protein) 5 : Unknown function e : enzyme 1 : Unknown 2015-11-19 17:09:10 no 3 vladimir 0.329787 0.1986 0.244681 0.22695 0.443262 0.556738 0.340426 0.117021 0.351064 0.191489 0.468085 0.531915 0.308511 0.223404 0.159574 0.308511 0.382979 0.617021 0.340426 0.255319 0.223404 0.180851 0.478723 0.521277 0.623569 10086.36 0.063441 0.322581 0.462366 0.236559 0.064516 0.580645 0.419355 0.258065 0.139785 0.11828 6.314537 9.451613 NMV_1906 2192868 CDS -2 1833511 1833969 459 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-01 11:09:24 no 3 vladimir 0.352941 0.1002 0.169935 0.376906 0.270153 0.729847 0.359477 0.078431 0.24183 0.320261 0.320261 0.679739 0.418301 0.104575 0.111111 0.366013 0.215686 0.784314 0.281046 0.117647 0.156863 0.444444 0.27451 0.72549 0.495591 17846.845 -0.046711 0.177632 0.401316 0.256579 0.184211 0.572368 0.427632 0.230263 0.105263 0.125 4.966682 8.473684 NMV_1908 2192870 CDS -2 1834252 1834530 279 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 11:09:10 no 3 vladimir 0.34767 0.0860 0.107527 0.458781 0.193548 0.806452 0.387097 0.064516 0.129032 0.419355 0.193548 0.806452 0.301075 0.086022 0.075269 0.537634 0.16129 0.83871 0.354839 0.107527 0.11828 0.419355 0.225806 0.774194 0.43897 10996.985 1.008696 0.152174 0.26087 0.358696 0.23913 0.684783 0.315217 0.163043 0.119565 0.043478 9.481499 7.173913 NMV_1909 2192871 CDS -3 1834533 1834736 204 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:08:59 no 3 vladimir 0.357843 0.1373 0.264706 0.240196 0.401961 0.598039 0.264706 0.117647 0.411765 0.205882 0.529412 0.470588 0.25 0.264706 0.235294 0.25 0.5 0.5 0.558824 0.029412 0.147059 0.264706 0.176471 0.823529 0.388126 6753.44 0.152239 0.447761 0.537313 0.223881 0.059701 0.641791 0.358209 0.164179 0.089552 0.074627 6.767204 8.731343 NMV_1912 2192874 CDS -3 1835301 1836236 936 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:08:48 no 1 vladimir 0.287393 0.2286 0.225427 0.258547 0.45406 0.54594 0.278846 0.208333 0.304487 0.208333 0.51282 0.487179 0.403846 0.192308 0.105769 0.298077 0.298077 0.701923 0.179487 0.285256 0.266026 0.269231 0.551282 0.448718 0.647544 36514.37 -0.402251 0.202572 0.421222 0.186495 0.170418 0.549839 0.450161 0.282958 0.131833 0.151125 5.018593 9.649518 NMV_1914 2192876 CDS -3 1836747 1837190 444 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-19 17:07:47 no 3 vladimir 0.274775 0.1126 0.177928 0.434685 0.290541 0.709459 0.290541 0.101351 0.22973 0.378378 0.331081 0.668919 0.195946 0.141892 0.175676 0.486486 0.317568 0.682432 0.337838 0.094595 0.128378 0.439189 0.222973 0.777027 0.438109 16944.41 0.908844 0.238095 0.414966 0.319728 0.22449 0.70068 0.29932 0.088435 0.054422 0.034014 9.01313 7.918367 NMV_1915 2192877 CDS -2 1837249 1838922 1674 validated/Curated partial tpsS12 putative TpsS12 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 14:19:41 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 3 vladimir 0.297491 0.2043 0.262246 0.235962 0.466547 0.533453 0.331541 0.129032 0.38172 0.157706 0.510753 0.489247 0.322581 0.263441 0.168459 0.24552 0.4319 0.5681 0.238351 0.22043 0.236559 0.304659 0.456989 0.543011 0.55656 59401.03 -0.14237 0.359066 0.56912 0.208259 0.082585 0.561939 0.438061 0.217235 0.127469 0.089767 9.221413 9.030521 NMV_1916 2192878 CDS -2 1839235 1839609 375 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 11:07:52 no 3 vladimir 0.344 0.1520 0.189333 0.314667 0.341333 0.658667 0.304 0.16 0.272 0.264 0.432 0.568 0.432 0.168 0.112 0.288 0.28 0.72 0.296 0.128 0.184 0.392 0.312 0.688 0.60209 14553.885 -0.424194 0.177419 0.419355 0.241935 0.129032 0.524194 0.475806 0.266129 0.08871 0.177419 4.207253 8.717742 NMV_1917 2192879 CDS -2 1839628 1841571 1944 validated/Curated partial tpsS13 putative TpsS13 cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 14:19:57 no 16472308 Is likely to be a non-expressed (silent) variable TpsA minicassette. N-terminus shows homology to TpsA whereas C-terminus is divergent. Is expected to allow antigenic variation of TpsA upon recombination at the tpsA gene. 1 vladimir 0.292082 0.2342 0.257468 0.216216 0.491702 0.508298 0.347084 0.146515 0.376956 0.129445 0.523471 0.476529 0.273115 0.301565 0.176387 0.248933 0.477952 0.522048 0.256046 0.254623 0.219061 0.27027 0.473684 0.526316 0.578846 72894.115 0.006125 0.39886 0.602564 0.207977 0.062678 0.584046 0.415954 0.162393 0.098291 0.064103 9.474342 8.964387 NMV_1918 2192880 CDS -3 1841778 1842287 510 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:07:34 no 3 vladimir 0.386275 0.1176 0.137255 0.358824 0.254902 0.745098 0.347059 0.111765 0.217647 0.323529 0.329412 0.670588 0.441176 0.123529 0.111765 0.323529 0.235294 0.764706 0.370588 0.117647 0.082353 0.429412 0.2 0.8 0.582145 20333.58 -0.377515 0.16568 0.366864 0.236686 0.171598 0.502959 0.497041 0.284024 0.136095 0.147929 5.254539 9.278107 NMV_1919 2192881 CDS -3 1842294 1848221 5928 validated/Curated no tpsA3 haemagglutinin/hemolysin-related protein TpsA3 1b : Function from experimental evidences in the studied species f : factor 10 : Secreted 2018-01-27 14:20:20 no 15546669, 16472308, 17873034 Belongs to a family of large secreted proteins that may have haemagglutinin or haemolysin activity. These proteins, encoded by genes generically designated tpsA, are secreted by the two-partner secretion system (TPS) in which the transport across the outer membrane requires a dedicated outer membrane protein, encoded by genes generically designated tpsB. 1 vladimir 0.301113 0.2515 0.240047 0.207321 0.491565 0.508435 0.360324 0.15587 0.370445 0.11336 0.526316 0.473684 0.303644 0.282389 0.174595 0.239372 0.456984 0.543016 0.239372 0.316296 0.175101 0.269231 0.491397 0.508603 0.635246 204725.1 -0.203443 0.395949 0.603544 0.217722 0.052152 0.519494 0.480506 0.201519 0.122532 0.078987 9.516426 8.719494 NMV_1920 2192882 CDS -3 1848330 1850072 1743 validated/Curated no tpsB3 TpsA3 activation/secretion protein TpsB3 1b : Function from experimental evidences in the studied species t : transporter 7 : Outer membrane protein 2018-01-27 14:20:39 no 15546669, 16472308, 17873034 Belongs to a family of outer membrane proteins, encoded by genes generically designated tpsB, that transport the TpsA proteins across the outer membrane during a process known as two-partner secretion (TPS). 1 vladimir 0.282846 0.2301 0.242111 0.24498 0.472174 0.527826 0.277108 0.209983 0.306368 0.20654 0.516351 0.483649 0.340792 0.199656 0.209983 0.24957 0.409639 0.590361 0.230637 0.280551 0.209983 0.27883 0.490534 0.509466 0.593873 65517.525 -0.543276 0.294828 0.47069 0.182759 0.132759 0.513793 0.486207 0.253448 0.151724 0.101724 9.38932 9.363793 NMV_1921 2192883 CDS -2 1850230 1850382 153 validated/Curated partial truncated putative bacteriocin/pheromone secretion/processing ATP-binding protein (N-terminal 8% of the protein) 5 : Unknown function e : enzyme 1 : Unknown 2008-06-12 16:29:11 no 1 vladimir 0.270833 0.2552 0.213542 0.260417 0.46875 0.53125 0.234375 0.28125 0.234375 0.25 0.515625 0.484375 0.28125 0.265625 0.140625 0.3125 0.40625 0.59375 0.296875 0.21875 0.265625 0.21875 0.484375 0.515625 0.612105 6949.08 0.142857 0.301587 0.444444 0.238095 0.126984 0.619048 0.380952 0.238095 0.190476 0.047619 9.673332 8.238095 NMV_1922 2192884 CDS -3 1850481 1850648 168 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2015-11-21 18:32:29 no 1 vladimir 0.274854 0.1696 0.157895 0.397661 0.327485 0.672515 0.368421 0.175439 0.122807 0.333333 0.298246 0.701754 0.245614 0.140351 0.105263 0.508772 0.245614 0.754386 0.210526 0.192982 0.245614 0.350877 0.438596 0.561404 0.552196 6768.125 1.021429 0.214286 0.25 0.303571 0.232143 0.714286 0.285714 0.142857 0.107143 0.035714 9.30558 8.214286 NMV_1923 2192885 CDS -1 1850666 1850968 303 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:06:22 no 3 vladimir 0.280528 0.1881 0.267327 0.264026 0.455446 0.544554 0.267327 0.138614 0.336634 0.257426 0.475248 0.524752 0.277228 0.257426 0.287129 0.178218 0.544554 0.455446 0.29703 0.168317 0.178218 0.356436 0.346535 0.653465 0.52828 10886.495 -0.525 0.4 0.57 0.12 0.14 0.57 0.43 0.18 0.07 0.11 4.602882 10.1 NMV_1924 2192886 fCDS -3 1851279 1851785 507 validated/Curated pseudo putative bacteriocin/pheromone secretion membrane fusion protein (pseudogene part 2) 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 14:21:12 no Belongs to the bacterial RTX (repeats in toxin) secretion protein D family. 1 vladimir 0.285996 0.2288 0.250493 0.234714 0.47929 0.52071 0.254438 0.224852 0.331361 0.189349 0.556213 0.443787 0.319527 0.213018 0.159763 0.307692 0.372781 0.627219 0.284024 0.248521 0.260355 0.207101 0.508876 0.491124 0.552311 18705.985 -0.108929 0.267857 0.446429 0.267857 0.095238 0.571429 0.428571 0.25 0.136905 0.113095 8.685005 8.732143 NMV_1925 2192887 fCDS -2 1851847 1852554 708 validated/Curated pseudo putative bacteriocin/pheromone secretion membrane fusion protein (pseudogene part 1) 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 14:21:24 no Belongs to the bacterial RTX (repeats in toxin) secretion protein D family. 3 vladimir 0.298466 0.2259 0.25802 0.217573 0.483961 0.516039 0.288703 0.246862 0.309623 0.154812 0.556485 0.443515 0.309623 0.238494 0.150628 0.301255 0.389121 0.610879 0.297071 0.192469 0.313808 0.196653 0.506276 0.493724 0.468282 26725.005 -0.27437 0.277311 0.428571 0.243697 0.071429 0.504202 0.495798 0.264706 0.159664 0.105042 9.876701 8.915966 NMV_1926 2192888 CDS -2 1852714 1852974 261 validated/Curated no putative bacteriocin/pheromone 3 : Putative function from multiple computational evidences f : factor 10 : Secreted 2018-01-27 14:21:41 no Although its N-terminus is degenerated, could be a pheromone or a bacteriocin toxic to closely related bacteria. Processing of the N-terminal region up to the GG cleavage motif occurs together with export by a neighbouring ABC transporter 3 vladimir 0.256705 0.1379 0.310345 0.295019 0.448276 0.551724 0.264368 0.091954 0.517241 0.126437 0.609195 0.390805 0.206897 0.195402 0.287356 0.310345 0.482759 0.517241 0.298851 0.126437 0.126437 0.448276 0.252874 0.747126 0.485753 8299.115 0.609302 0.44186 0.581395 0.302326 0.046512 0.755814 0.244186 0.127907 0.046512 0.081395 4.546593 9.127907 NMV_1927 2192889 CDS -1 1852958 1853137 180 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 11:05:50 no 3 vladimir 0.305556 0.1056 0.144444 0.444444 0.25 0.75 0.333333 0.1 0.216667 0.35 0.316667 0.683333 0.316667 0.133333 0.083333 0.466667 0.216667 0.783333 0.266667 0.083333 0.133333 0.516667 0.216667 0.783333 0.58191 6985.07 0.837288 0.186441 0.338983 0.338983 0.20339 0.677966 0.322034 0.152542 0.067797 0.084746 4.938911 8.389831 NMV_1928 2192890 CDS -2 1853179 1853385 207 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 11:05:30 no 3 vladimir 0.31401 0.1256 0.135266 0.425121 0.26087 0.73913 0.347826 0.144928 0.115942 0.391304 0.26087 0.73913 0.318841 0.101449 0.130435 0.449275 0.231884 0.768116 0.275362 0.130435 0.15942 0.434783 0.289855 0.710145 0.470983 8415.605 0.455882 0.147059 0.352941 0.279412 0.264706 0.632353 0.367647 0.102941 0.073529 0.029412 9.254631 8.705882 NMV_1929 2192891 fCDS -3 1853394 1854203 810 validated/Curated pseudo conserved hypothetical protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:31:22 no 1 vladimir 0.279012 0.2210 0.225926 0.274074 0.446914 0.553086 0.292593 0.211111 0.303704 0.192593 0.514815 0.485185 0.359259 0.181481 0.155556 0.303704 0.337037 0.662963 0.185185 0.27037 0.218519 0.325926 0.488889 0.511111 0.549394 30998.2 -0.327881 0.211896 0.434944 0.234201 0.141264 0.550186 0.449814 0.275093 0.130112 0.144981 5.11718 9.275093 NMV_1930 2192892 fCDS -3 1854222 1854542 321 validated/Curated pseudo conserved hypothetical protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:31:36 no 1 vladimir 0.314642 0.2274 0.196262 0.261682 0.423676 0.576324 0.308411 0.233645 0.271028 0.186916 0.504673 0.495327 0.392523 0.17757 0.140187 0.28972 0.317757 0.682243 0.242991 0.271028 0.17757 0.308411 0.448598 0.551402 0.597415 12406.865 -0.451887 0.207547 0.40566 0.216981 0.169811 0.528302 0.471698 0.311321 0.198113 0.113208 9.45533 8.867925 NMV_1931 2192893 CDS +1 1854904 1855185 282 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-05-01 11:04:34 no 2 vladimir 0.234043 0.3121 0.223404 0.230496 0.535461 0.464539 0.212766 0.234043 0.319149 0.234043 0.553191 0.446809 0.287234 0.308511 0.159574 0.244681 0.468085 0.531915 0.202128 0.393617 0.191489 0.212766 0.585106 0.414894 0.55219 10256.37 -0.270968 0.333333 0.526882 0.182796 0.139785 0.591398 0.408602 0.204301 0.139785 0.064516 9.796486 9.075269 NMV_1932 2192894 CDS +3 1855182 1856225 1044 validated/Curated no argC N-acetyl-gamma-glutamyl-phosphate reductase (AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 1.2.1.38 N-ACETYLGLUTPREDUCT-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$GLUTORN-PWY 2018-01-27 14:22:40 no Catalyses the third step in the biosynthesis of arginine from glutamate: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> N-acetyl-5-glutamyl phosphate + NADPH. 2 vladimir 0.202107 0.3448 0.27682 0.176245 0.621648 0.378352 0.212644 0.261494 0.387931 0.137931 0.649425 0.350575 0.244253 0.241379 0.212644 0.301724 0.454023 0.545977 0.149425 0.531609 0.229885 0.08908 0.761494 0.238506 0.648146 37184.32 0.12536 0.32853 0.553314 0.25072 0.092219 0.62536 0.37464 0.207493 0.112392 0.095101 6.338036 9.54755 NMV_1933 2192895 CDS -2 1857187 1859229 2043 validated/Curated no recG ATP-dependent DNA helicase RecG 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2.1.4 : DNA repair ; 3.6.4.12 RXN0-2604 2018-01-23 11:53:17 no Plays a critical role in recombination and DNA repair. It helps to process Holliday junction intermediates to mature products by catalysing branch migration. RecG has DNA unwinding activity characteristic of a DNA helicase with 3' to 5' polarity. 2 vladimir 0.219775 0.3025 0.279491 0.198238 0.581987 0.418013 0.22467 0.28928 0.361233 0.124816 0.650514 0.349486 0.281938 0.22467 0.174743 0.318649 0.399413 0.600587 0.152717 0.393539 0.302496 0.151248 0.696035 0.303965 0.651317 74994.225 -0.042647 0.276471 0.461765 0.263235 0.086765 0.570588 0.429412 0.264706 0.151471 0.113235 8.146782 9.260294 NMV_1934 2192896 CDS -1 1859315 1859758 444 validated/Curated no secB protein translocase SecB subunit 2a : Function from experimental evidences in other organisms t : transporter 2 : Cytoplasmic 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:21:37 no Part of the prokaryotic protein translocation apparatus essential for protein export. 2 vladimir 0.245495 0.2770 0.27027 0.207207 0.547297 0.452703 0.216216 0.243243 0.385135 0.155405 0.628378 0.371622 0.324324 0.222973 0.135135 0.317568 0.358108 0.641892 0.195946 0.364865 0.290541 0.148649 0.655405 0.344595 0.736246 16375.92 -0.10068 0.244898 0.496599 0.251701 0.088435 0.557823 0.442177 0.22449 0.068027 0.156463 4.241646 9.843537 NMV_1935 2192897 CDS -2 1859779 1860036 258 validated/Curated no grX glutaredoxin 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.6.15.2 : Thioredoxin, glutaredoxin ; 2018-01-27 14:23:30 no Functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active center disulphide bond. It exists in either a reduced or an oxidised form where the two cysteine residues are linked by an intramolecular disulphide bond. 2 vladimir 0.22093 0.2984 0.290698 0.189922 0.589147 0.410853 0.209302 0.302326 0.360465 0.127907 0.662791 0.337209 0.290698 0.209302 0.209302 0.290698 0.418605 0.581395 0.162791 0.383721 0.302326 0.151163 0.686047 0.313953 0.597801 9282.23 -0.082353 0.317647 0.494118 0.2 0.117647 0.611765 0.388235 0.2 0.094118 0.105882 5.074883 10.105882 NMV_1936 2192898 CDS +1 1860250 1861743 1494 validated/Curated no rng cafA ribonuclease G (RNase G; cytoplasmic axial filament protein) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2 : RNA related ; 3.1.26.- RXN0-6523 2018-01-23 13:47:10 no Is involved in processing of the 5' end of 16S rRNA and may be involved in chromosome segregation and cell division too. 2 vladimir 0.246319 0.3213 0.251004 0.181392 0.572289 0.427711 0.25502 0.281125 0.327309 0.136546 0.608434 0.391566 0.315261 0.186747 0.180723 0.317269 0.36747 0.63253 0.168675 0.495984 0.24498 0.090361 0.740964 0.259036 0.69015 56590.69 -0.243461 0.237425 0.43662 0.265594 0.082495 0.511066 0.488934 0.285714 0.138833 0.146881 5.354515 9.925553 NMV_1937 2192899 CDS -1 1861778 1863028 1251 validated/Curated no putative two-component system sensor protein 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2.7.13.3 2.7.13.3-RXN 2018-01-22 20:09:51 no Phosphotransfer-mediated signaling pathways allow cells to sense and respond to extra-cytoplasmic stimuli in bacteria. Autophosphorylating histidine protein kinases (HPKs) provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. 1 vladimir 0.233413 0.2694 0.285372 0.211831 0.554756 0.445244 0.213429 0.282974 0.354916 0.148681 0.63789 0.36211 0.311751 0.227818 0.160671 0.29976 0.388489 0.611511 0.17506 0.297362 0.340528 0.18705 0.63789 0.36211 0.585136 46771.595 -0.270913 0.259615 0.461538 0.245192 0.086538 0.533654 0.466346 0.276442 0.129808 0.146635 5.106606 9.574519 NMV_1938 2192900 CDS -1 1863092 1863199 108 validated/Curated partial truncated two-component system transcriptional regulator protein (N-terminal 20% of the protein) 5 : Unknown function r : regulator 2 : Cytoplasmic 2008-06-12 16:31:00 no 2 vladimir 0.204082 0.1837 0.380952 0.231293 0.564626 0.435374 0.244898 0.163265 0.428571 0.163265 0.591837 0.408163 0.244898 0.204082 0.204082 0.346939 0.408163 0.591837 0.122449 0.183673 0.510204 0.183673 0.693878 0.306122 0.592315 5143.855 0.275 0.291667 0.541667 0.291667 0.041667 0.645833 0.354167 0.25 0.125 0.125 5.941444 8.854167 NMV_1940 2192902 CDS -3 1863417 1864730 1314 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 14:24:17 no Belongs to a family of transporters including two characterised citrate/proton symporters from B. subtilis. 1 vladimir 0.165145 0.2047 0.324962 0.305175 0.52968 0.47032 0.22831 0.200913 0.3379 0.232877 0.538813 0.461187 0.157534 0.237443 0.159817 0.445205 0.39726 0.60274 0.109589 0.175799 0.477169 0.237443 0.652968 0.347032 0.600927 46749.55 1.020366 0.297483 0.475973 0.356979 0.107551 0.748284 0.251716 0.121281 0.070938 0.050343 9.136391 8.12357 NMV_1941 2192903 CDS -2 1865299 1865865 567 validated/Curated no putative oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-05-01 11:01:24 no 1 vladimir 0.252205 0.2346 0.268078 0.24515 0.502646 0.497355 0.285714 0.169312 0.349206 0.195767 0.518519 0.481481 0.31746 0.232804 0.153439 0.296296 0.386243 0.613757 0.153439 0.301587 0.301587 0.243386 0.603175 0.396825 0.689538 20713.765 -0.166489 0.276596 0.531915 0.223404 0.106383 0.56383 0.43617 0.234043 0.117021 0.117021 5.745018 9.031915 NMV_1942 2192904 CDS +3 1865913 1867439 1527 validated/Curated no dacB D-alanyl-D-alanine carboxypeptidase DacB (DD-peptidase; DD-carboxypeptidase) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 3.4.16.4 RXN0-3461 2018-01-22 16:11:24 no Not involved in transpeptidation but exclusively catalyses a DD-carboxypeptidase and DD-endopeptidase reaction. Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 2 vladimir 0.229787 0.3043 0.263121 0.202837 0.567376 0.432624 0.274468 0.234043 0.353191 0.138298 0.587234 0.412766 0.261702 0.248936 0.191489 0.297872 0.440426 0.559574 0.153191 0.429787 0.244681 0.17234 0.674468 0.325532 0.651794 50659.83 -0.09339 0.319829 0.554371 0.226013 0.076759 0.565032 0.434968 0.219616 0.115139 0.104478 6.447731 9.183369 NMV_1943 2192905 fCDS -3 1867515 1867706 192 validated/Curated pseudo IS1016 group transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:32:01 no 3 vladimir 0.311966 0.1923 0.192308 0.303419 0.384615 0.615385 0.320513 0.24359 0.205128 0.230769 0.448718 0.551282 0.384615 0.128205 0.179487 0.307692 0.307692 0.692308 0.230769 0.205128 0.192308 0.371795 0.397436 0.602564 0.536944 9250.37 -0.428571 0.181818 0.350649 0.207792 0.194805 0.506494 0.493506 0.298701 0.220779 0.077922 9.918037 9.584416 NMV_1944 2192906 fCDS -2 1867705 1868181 477 validated/Curated pseudo IS1016 group transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:32:15 no 3 vladimir 0.289524 0.2000 0.205714 0.304762 0.405714 0.594286 0.24 0.2 0.325714 0.234286 0.525714 0.474286 0.32 0.222857 0.171429 0.285714 0.394286 0.605714 0.308571 0.177143 0.12 0.394286 0.297143 0.702857 0.562411 19716.785 -0.200575 0.287356 0.505747 0.212644 0.16092 0.551724 0.448276 0.247126 0.149425 0.097701 8.931099 9.528736 NMV_1945 2192907 CDS -2 1868383 1869390 1008 validated/Curated no ISNme1 transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 14:24:36 no Belongs to the IS5 family. 2 vladimir 0.282738 0.2966 0.229167 0.191468 0.525794 0.474206 0.282738 0.285714 0.270833 0.160714 0.556548 0.443452 0.363095 0.205357 0.184524 0.247024 0.389881 0.610119 0.202381 0.39881 0.232143 0.166667 0.630952 0.369048 0.652727 38494.59 -0.56806 0.268657 0.423881 0.202985 0.122388 0.486567 0.513433 0.292537 0.18209 0.110448 9.321709 9.325373 NMV_1946 2192908 CDS +2 1869431 1870270 840 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-05-01 11:00:20 no 1 vladimir 0.329762 0.2262 0.3 0.144048 0.52619 0.47381 0.278571 0.257143 0.357143 0.107143 0.614286 0.385714 0.460714 0.132143 0.189286 0.217857 0.321429 0.678571 0.25 0.289286 0.353571 0.107143 0.642857 0.357143 0.516953 33129.94 -1.224373 0.175627 0.369176 0.150538 0.100358 0.422939 0.577061 0.397849 0.218638 0.179211 9.093666 10.706093 NMV_1948 2192910 CDS -2 1870540 1871802 1263 validated/Curated no putative bacteriocin/pheromone secretion membrane fusion protein 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 14:24:57 no Belongs to the bacterial RTX (repeats in toxin) secretion protein D family. 3 vladimir 0.35867 0.1774 0.191607 0.272367 0.368963 0.631037 0.308789 0.209026 0.296912 0.185273 0.505938 0.494062 0.372922 0.192399 0.12114 0.313539 0.313539 0.686461 0.394299 0.130641 0.15677 0.31829 0.287411 0.712589 0.541423 47902.255 -0.259286 0.235714 0.414286 0.254762 0.1 0.507143 0.492857 0.238095 0.135714 0.102381 8.999779 9.22619 NMV_1949 2192911 CDS -1 1871804 1873900 2097 validated/Curated no putative bacteriocin/pheromone secretion/processing ATP-binding protein 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 3.4.22.- 2018-01-23 11:36:01 no Belongs to the MEROPS cysteine peptidase family C39 and to the ATP-binding cassette ABC-type family. Is involved in the secretion and the proteolytic maturation of neighbouring bacteriocins/pheromones. 3 vladimir 0.266094 0.1736 0.230329 0.329995 0.40391 0.59609 0.270386 0.183119 0.298999 0.247496 0.482117 0.517883 0.263233 0.191702 0.16309 0.381974 0.354793 0.645207 0.264664 0.145923 0.228898 0.360515 0.374821 0.625179 0.56685 78301.255 0.319054 0.269341 0.458453 0.287966 0.12894 0.588825 0.411175 0.19914 0.116046 0.083095 7.473442 8.901146 NMV_1950 2192912 CDS -3 1873935 1874270 336 validated/Curated no putative bacteriocin/pheromone 3 : Putative function from multiple computational evidences f : factor 10 : Secreted 2018-01-27 14:25:13 no Could be a pheromone or a bacteriocin toxic to closely related bacteria. Processing of the N-terminal region up to the GG cleavage motif occurs together with export by a neighbouring ABC transporter. 3 vladimir 0.306548 0.1399 0.247024 0.306548 0.386905 0.613095 0.276786 0.089286 0.4375 0.196429 0.526786 0.473214 0.241071 0.25 0.223214 0.285714 0.473214 0.526786 0.401786 0.080357 0.080357 0.4375 0.160714 0.839286 0.463521 11507.45 0.076577 0.396396 0.630631 0.252252 0.063063 0.594595 0.405405 0.18018 0.081081 0.099099 4.887428 9.477477 NMV_1951 2192913 CDS -1 1874294 1874500 207 validated/Curated no hypothetical membrane-associated protein 5 : Unknown function u : unknown 11 : Membrane 2008-05-01 10:53:42 no 3 vladimir 0.256039 0.0918 0.149758 0.502415 0.241546 0.758454 0.333333 0.043478 0.217391 0.405797 0.26087 0.73913 0.202899 0.144928 0.130435 0.521739 0.275362 0.724638 0.231884 0.086957 0.101449 0.57971 0.188406 0.811594 0.534628 7877.035 1.176471 0.279412 0.426471 0.25 0.294118 0.691176 0.308824 0.102941 0.058824 0.044118 6.741676 7.397059 NMV_1952 2192914 CDS -1 1874507 1875670 1164 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 10:53:31 no 3 vladimir 0.354811 0.1495 0.186426 0.309278 0.335911 0.664089 0.347938 0.17268 0.268041 0.21134 0.440722 0.559278 0.412371 0.17268 0.123711 0.291237 0.296392 0.703608 0.304124 0.103093 0.167526 0.425258 0.270619 0.729381 0.62249 45381.65 -0.513695 0.193798 0.444444 0.198966 0.147287 0.503876 0.496124 0.248062 0.121447 0.126615 5.354195 9.661499 NMV_1953 2192915 CDS -3 1875846 1876049 204 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-05-01 10:52:55 no 3 vladimir 0.372549 0.1471 0.205882 0.27451 0.352941 0.647059 0.382353 0.117647 0.323529 0.176471 0.441176 0.558824 0.411765 0.161765 0.117647 0.308824 0.279412 0.720588 0.323529 0.161765 0.176471 0.338235 0.338235 0.661765 0.562957 7568.4 -0.471642 0.208955 0.462687 0.268657 0.044776 0.447761 0.552239 0.343284 0.19403 0.149254 9.10659 8.656716 NMV_1955 2192917 fCDS -3 1876092 1876385 294 validated/Curated pseudo putative ParA-like protein (pseudogene part 2) 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-27 14:26:03 no Belongs to the ParA family of proteins often involved in chromosome partition. 3 vladimir 0.384354 0.1361 0.190476 0.289116 0.326531 0.673469 0.408163 0.132653 0.306122 0.153061 0.438776 0.561225 0.336735 0.204082 0.112245 0.346939 0.316327 0.683673 0.408163 0.071429 0.153061 0.367347 0.22449 0.77551 0.393993 10646.99 0.142268 0.247423 0.443299 0.340206 0.041237 0.546392 0.453608 0.237113 0.123711 0.113402 6.801277 8.57732 NMV_1956 2192918 fCDS -3 1876512 1876736 225 validated/Curated pseudo putative ParA-like protein (pseudogene part 1) 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-27 14:26:15 no Belongs to the ParA family of proteins often involved in chromosome partition. 3 vladimir 0.302222 0.1867 0.248889 0.262222 0.435556 0.564444 0.32 0.16 0.386667 0.133333 0.546667 0.453333 0.28 0.2 0.226667 0.293333 0.426667 0.573333 0.306667 0.2 0.133333 0.36 0.333333 0.666667 0.599317 7788.505 -0.051351 0.324324 0.608108 0.283784 0.040541 0.527027 0.472973 0.22973 0.121622 0.108108 6.044304 8.297297 NMNmiscRNA0178 54921370 misc_RNA +1 1876870 1877084 215 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 14:12:10 28334889 Function unknown. vladimir NMV_1958 2192920 fCDS -2 1877083 1877799 717 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 14:26:26 no Belongs to the IS5 family. 2 vladimir 0.299861 0.2720 0.246862 0.181311 0.518828 0.481172 0.301255 0.246862 0.301255 0.150628 0.548117 0.451883 0.376569 0.209205 0.188285 0.225941 0.39749 0.60251 0.221757 0.359833 0.251046 0.167364 0.610879 0.389121 0.618122 26935.765 -0.560924 0.298319 0.436975 0.205882 0.105042 0.487395 0.512605 0.302521 0.189076 0.113445 9.259758 9.478992 NMV_1959 2192921 fCDS -2 1877944 1878213 270 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 14:26:35 no Belongs to the IS5 family. 2 vladimir 0.245098 0.3170 0.205882 0.232026 0.522876 0.477124 0.254902 0.352941 0.205882 0.186275 0.558824 0.441176 0.313726 0.147059 0.196078 0.343137 0.343137 0.656863 0.166667 0.45098 0.215686 0.166667 0.666667 0.333333 0.623921 12117.63 -0.263366 0.178218 0.356436 0.247525 0.158416 0.524752 0.475248 0.277228 0.168317 0.108911 8.988457 9.168317 NMV_1960 2192922 CDS -2 1878403 1879572 1170 validated/Curated no metK S-adenosylmethionine synthase (methionine adenosyltransferase; AdoMet synthetase; MAT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.20 : S-adenosyl methionine biosynthesis ; 2.5.1.6 S-ADENMETSYN-RXN PWY-6151$SAM-PWY 2020-04-21 16:34:26 no Catalyses the following reaction: ATP + L-methionine + H(2)O <=> phosphate + diphosphate + S-adenosyl-L-methionine. 2 vladimir 0.24188 0.3188 0.255556 0.183761 0.574359 0.425641 0.238462 0.202564 0.392308 0.166667 0.594872 0.405128 0.310256 0.25641 0.176923 0.25641 0.433333 0.566667 0.176923 0.497436 0.197436 0.128205 0.694872 0.305128 0.802847 42117.06 -0.201542 0.33419 0.537275 0.218509 0.089974 0.562982 0.437018 0.246787 0.118252 0.128535 5.241295 9.40874 NMNmisc_RNA1879746R 19685115 misc_RNA -1 1879750 1879851 102 validated/Curated no SAM-I/IV variant riboswitch 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 18:46:05 28334889 The SAM riboswitch (also known as the S-box leader and now also called the SAM-I riboswitch) is found upstream of a number of genes which code for proteins involved in methionine or cysteine biosynthesis. vladimir NMV_1961 2192923 CDS +1 1879909 1880805 897 validated/Curated no putative lipid A biosynthesis acyltransferase 3 : Putative function from multiple computational evidences e : enzyme 6 : Inner membrane-associated 1.6.3 : Lipopolysaccharide ; 2.3.1.- MYRISTOYLACYLTRAN-RXN KDO-LIPASYN-PWY$KDO-NAGLIPASYN-PWY 2020-02-23 20:52:42 no Transfers an acyl group to the lipid A moiety during lipooligosaccharide core biosynthesis. 2 vladimir 0.250836 0.2977 0.250836 0.200669 0.548495 0.451505 0.250836 0.277592 0.304348 0.167224 0.58194 0.41806 0.287625 0.22408 0.180602 0.307692 0.404682 0.595318 0.214047 0.391304 0.267559 0.12709 0.658863 0.341137 0.646437 33467.995 -0.140268 0.265101 0.446309 0.214765 0.137584 0.607383 0.392617 0.251678 0.171141 0.080537 9.771385 9.332215 NMV_1962 2192924 CDS -1 1880849 1881913 1065 validated/Curated no tsaD tRNA N6-adenosine threonylcarbamoyltransferase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.3.1.234 2018-01-27 14:28:17 no The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). 1 vladimir 0.201878 0.2582 0.324883 0.215023 0.583099 0.416901 0.2 0.211268 0.425352 0.16338 0.63662 0.36338 0.253521 0.264789 0.188732 0.292958 0.453521 0.546479 0.152113 0.298592 0.360563 0.188732 0.659155 0.340845 0.640739 37558.645 0.04209 0.336158 0.556497 0.225989 0.09322 0.621469 0.378531 0.240113 0.127119 0.112994 6.015358 9.471751 NMV_1963 2192925 CDS -2 1882030 1883217 1188 validated/Curated no ccsA cytochrome c biogenesis protein CcsA 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 5 : Inner membrane protein 2020-02-21 11:42:53 no Required during biogenesis of c-type cytochromes at the step of heme attachment. 1 vladimir 0.170875 0.2281 0.297138 0.303872 0.525253 0.474747 0.219697 0.184343 0.335859 0.260101 0.520202 0.479798 0.186869 0.217172 0.194444 0.401515 0.411616 0.588384 0.106061 0.282828 0.361111 0.25 0.643939 0.356061 0.691707 44454.88 0.8 0.298734 0.460759 0.288608 0.202532 0.731646 0.268354 0.129114 0.081013 0.048101 8.891365 8.663291 NMV_1964 2192926 CDS -1 1883210 1885225 2016 validated/Curated no ccsB cytochrome c biogenesis protein CcsB 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 5 : Inner membrane protein 2020-02-21 11:43:07 no Required during biogenesis of c-type cytochromes at the step of heme attachment. 1 vladimir 0.233999 0.2192 0.283154 0.263697 0.502304 0.497696 0.25192 0.213518 0.328725 0.205837 0.542243 0.457757 0.313364 0.193548 0.170507 0.322581 0.364055 0.635945 0.136713 0.250384 0.35023 0.262673 0.600614 0.399386 0.642573 73544.975 -0.154308 0.258462 0.450769 0.235385 0.121538 0.558462 0.441538 0.249231 0.136923 0.112308 8.834755 9.113846 NMV_1965 2192927 CDS -1 1885439 1886062 624 validated/Curated no cyc cytochrome c4 2b : Function from indirect experimental evidences (e.g. phenotypes) c : carrier 9 : Periplasmic 2018-01-31 14:30:04 no Diheme, high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems. 1 vladimir 0.264423 0.2260 0.272436 0.237179 0.498397 0.501603 0.264423 0.177885 0.384615 0.173077 0.5625 0.4375 0.326923 0.259615 0.1875 0.225962 0.447115 0.552885 0.201923 0.240385 0.245192 0.3125 0.485577 0.514423 0.760799 21988.18 -0.316908 0.357488 0.545894 0.169082 0.082126 0.57971 0.42029 0.227053 0.144928 0.082126 9.246941 9.73913 NMV_1966 2192928 CDS +3 1886268 1886897 630 validated/Curated no putative GTPase EngB 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.1 : Cell division ; RXN0-5462 2018-01-30 15:12:47 no Might be necessary for normal cell division and for the maintenance of normal septation. 2 vladimir 0.287302 0.2905 0.203175 0.219048 0.493651 0.506349 0.295238 0.266667 0.285714 0.152381 0.552381 0.447619 0.347619 0.214286 0.138095 0.3 0.352381 0.647619 0.219048 0.390476 0.185714 0.204762 0.57619 0.42381 0.61784 23561.99 -0.340191 0.248804 0.478469 0.229665 0.119617 0.507177 0.492823 0.248804 0.15311 0.095694 9.39669 8.751196 NMV_1967 2192929 CDS -3 1887018 1889414 2397 validated/Curated no mrcA ponA penicillin-binding protein 1A (PBP-1a; PBP1a) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGase) and penicillin-sensitive transpeptidase (DD-transpeptidase)] 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.7 : Peptidoglycan (murein) ; 3.4.16.4, 2.4.1.129 RXN0-3461$RXN0-5405 PEPTIDOGLYCANSYN-PWY 2020-04-22 16:52:35 no Involved in cell wall formation by synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). 1 vladimir 0.23738 0.2111 0.304547 0.246975 0.515645 0.484355 0.267835 0.181477 0.374218 0.176471 0.555695 0.444305 0.310388 0.22403 0.190238 0.275344 0.414268 0.585732 0.133917 0.227785 0.349186 0.289111 0.576971 0.423029 0.580118 88144.175 -0.29198 0.299499 0.522556 0.209273 0.100251 0.56015 0.43985 0.236842 0.137845 0.098997 9.52401 9.696742 NMV_1968 2192930 CDS +1 1889566 1890681 1116 validated/Curated no pilM type IV pilus biogenesis protein PilM 1a : Function from experimental evidences in the studied strain f : factor 2 : Cytoplasmic 6.5 : Pilus ; 2020-04-25 14:40:41 no 15612916, 28588140 Plays a key role in filament assembly. Is required for pilus biogenesis. 1 vladimir 0.321685 0.2724 0.205197 0.200717 0.477599 0.522401 0.282258 0.204301 0.330645 0.182796 0.534946 0.465054 0.397849 0.244624 0.08871 0.268817 0.333333 0.666667 0.284946 0.36828 0.196237 0.150538 0.564516 0.435484 0.631999 41365.09 -0.315094 0.277628 0.471698 0.229111 0.091644 0.504043 0.495957 0.226415 0.105121 0.121294 5.074562 8.983827 NMV_1969 2192931 CDS +3 1890684 1891283 600 validated/Curated no pilN type IV pilus biogenesis protein PilN 1a : Function from experimental evidences in the studied strain f : factor 6 : Inner membrane-associated 6.5 : Pilus ; 2020-04-25 14:40:21 no 15612916, 28588140 Plays a key role in filament assembly. Is required for pilus biogenesis. 2 vladimir 0.321667 0.2833 0.221667 0.173333 0.505 0.495 0.375 0.22 0.28 0.125 0.5 0.5 0.38 0.245 0.1 0.275 0.345 0.655 0.21 0.385 0.285 0.12 0.67 0.33 0.55259 22256.58 -0.451256 0.271357 0.457286 0.21608 0.060302 0.467337 0.532663 0.246231 0.135678 0.110553 9.005867 9.050251 NMV_1970 2192932 CDS +3 1891284 1891931 648 validated/Curated no pilO type IV pilus biogenesis protein PilO 1a : Function from experimental evidences in the studied strain f : factor 5 : Inner membrane protein 6.5 : Pilus ; 2020-04-25 14:41:03 no 15612916, 28588140 Plays a key role in filament assembly. Is required for pilus biogenesis. 2 vladimir 0.290123 0.3009 0.209877 0.199074 0.510802 0.489198 0.310185 0.24537 0.310185 0.134259 0.555556 0.444444 0.342593 0.25463 0.12963 0.273148 0.384259 0.615741 0.217593 0.402778 0.189815 0.189815 0.592593 0.407407 0.640371 23314.47 -0.264651 0.306977 0.497674 0.237209 0.055814 0.506977 0.493023 0.223256 0.102326 0.12093 5.042625 8.502326 NMV_1971 2192933 CDS +2 1891949 1892494 546 validated/Curated no pilP type IV pilus biogenesis lipoprotein PilP 1a : Function from experimental evidences in the studied strain f : factor 6 : Inner membrane-associated 6.5 : Pilus ; 2020-04-25 14:44:49 no 15612916, 9157238, 28588140 Interacts with the secretin. Is required for pilus biogenesis. 2 vladimir 0.304029 0.2637 0.234432 0.197802 0.498169 0.501832 0.291209 0.197802 0.346154 0.164835 0.543956 0.456044 0.351648 0.241758 0.159341 0.247253 0.401099 0.598901 0.269231 0.351648 0.197802 0.181319 0.549451 0.450549 0.66306 20066.79 -0.460221 0.298343 0.502762 0.19337 0.088398 0.513812 0.486188 0.248619 0.110497 0.138122 4.942329 9.469613 NMV_1972 2192934 CDS +2 1892513 1894798 2286 validated/Curated no pilQ type IV pilus secretin PilQ 1a : Function from experimental evidences in the studied strain f : factor 7 : Outer membrane protein 6.5 : Pilus ; 2020-04-25 14:46:53 no 11101514, 11395444, 15612916, 8825101 Functions as a pore for translocation of the pilus onto the surface. 2 vladimir 0.289589 0.2983 0.227472 0.184602 0.525809 0.474191 0.334646 0.203412 0.330709 0.131234 0.534121 0.465879 0.307087 0.284777 0.136483 0.271654 0.42126 0.57874 0.227034 0.406824 0.215223 0.150919 0.622047 0.377953 0.707468 81752.84 -0.227595 0.328515 0.561104 0.22339 0.056505 0.51117 0.48883 0.214192 0.120894 0.093298 9.467827 8.609724 NMV_1973 2192935 CDS +3 1895976 1896488 513 validated/Curated no aroK shikimate kinase (SK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 2.7.1.71 SHIKIMATE-KINASE-RXN PWY-6163 2018-01-27 14:31:14 no Catalyses the fifth step in the biosynthesis of aromatic amino acids from chorismate (the so-called shikimate pathway): ATP + shikimate <=> ADP + shikimate 3-phosphate. 2 vladimir 0.247563 0.3294 0.241715 0.181287 0.57115 0.42885 0.245614 0.292398 0.333333 0.128655 0.625731 0.374269 0.280702 0.22807 0.192982 0.298246 0.421053 0.578947 0.216374 0.467836 0.19883 0.116959 0.666667 0.333333 0.64715 19007.375 -0.211176 0.282353 0.464706 0.247059 0.076471 0.547059 0.452941 0.276471 0.164706 0.111765 9.511192 9.764706 NMV_1974 2192936 CDS +1 1896568 1897647 1080 validated/Curated no aroB 3-dehydroquinate synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.20 : Chorismate ; 4.2.3.4 3-DEHYDROQUINATE-SYNTHASE-RXN PWY-6164 2018-01-27 14:31:41 no Catalyses the following reaction in the shikimate pathway: 3-deoxy-arabino-heptulonate 7-phosphate <=> 3-dehydroquinate + phosphate. 2 vladimir 0.225926 0.3389 0.262963 0.172222 0.601852 0.398148 0.236111 0.269444 0.366667 0.127778 0.636111 0.363889 0.261111 0.261111 0.177778 0.3 0.438889 0.561111 0.180556 0.486111 0.244444 0.088889 0.730556 0.269444 0.680327 38581.95 0.127855 0.339833 0.506964 0.236769 0.10585 0.618384 0.381616 0.200557 0.108635 0.091922 5.999229 9.259053 NMV_1975 2192937 CDS +3 1899249 1900091 843 validated/Curated no putative class-II glutamine amidotransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.4.2.- 2018-01-22 19:37:54 no Catalyses the removal of the ammonia group from glutamine and then the transfer of this group to a substrate to form a new carbon-nitrogen group. Class-II GATase also exhibit an amido phosphoribosyltransferase (glutamine phosphoribosylpyrophosphate amidotransferase) activity. 2 vladimir 0.202847 0.3345 0.255042 0.207592 0.589561 0.410439 0.206406 0.263345 0.366548 0.163701 0.629893 0.370107 0.274021 0.227758 0.188612 0.309609 0.41637 0.58363 0.128114 0.512456 0.209964 0.149466 0.72242 0.27758 0.726378 31431.435 -0.158214 0.285714 0.503571 0.196429 0.153571 0.560714 0.439286 0.275 0.142857 0.132143 5.681892 9.753571 NMV_1976 2192938 CDS +1 1900120 1900584 465 validated/Curated no nrdR transcriptional repressor NrdR 2a : Function from experimental evidences in other organisms r : regulator 1 : Unknown 2018-01-27 14:33:11 no Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. 2 vladimir 0.234409 0.3849 0.23871 0.141935 0.623656 0.376344 0.225806 0.316129 0.335484 0.122581 0.651613 0.348387 0.296774 0.296774 0.187097 0.219355 0.483871 0.516129 0.180645 0.541936 0.193548 0.083871 0.735484 0.264516 0.681085 17483.375 -0.688312 0.298701 0.5 0.155844 0.084416 0.474026 0.525974 0.350649 0.214286 0.136364 9.542061 10.279221 NMV_1977 2192939 CDS +2 1900616 1901725 1110 validated/Curated no ribD riboflavin biosynthesis protein RibD [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) and 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 3.5.4.26, 1.1.1.193 RIBOFLAVINSYNDEAM-RXN$RIBOFLAVINSYNREDUC-RXN RIBOSYN2-PWY 2020-04-23 10:28:35 no Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate. 2 vladimir 0.218919 0.3441 0.254955 0.181982 0.599099 0.400901 0.208108 0.294595 0.364865 0.132432 0.659459 0.340541 0.243243 0.262162 0.208108 0.286486 0.47027 0.52973 0.205405 0.475676 0.191892 0.127027 0.667568 0.332432 0.648944 39996.37 -0.092412 0.327913 0.520325 0.233062 0.081301 0.569106 0.430894 0.257453 0.143631 0.113821 6.942375 9.520325 NMV_1978 2192940 CDS +1 1901920 1903341 1422 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2018-01-27 14:35:20 no Is a member of a family of integral membrane proteins, of which many are implicated in the production of polysaccharide. 2 vladimir 0.156821 0.3390 0.266526 0.237693 0.605485 0.394515 0.166667 0.28692 0.320675 0.225738 0.607595 0.392405 0.156118 0.312236 0.162447 0.369198 0.474684 0.525316 0.147679 0.417722 0.316456 0.118143 0.734177 0.265823 0.625972 50714.5 0.816702 0.359408 0.503171 0.295983 0.122622 0.716702 0.283298 0.135307 0.090909 0.044397 9.493889 8.367865 NMV_1981 2192943 CDS +3 1903509 1905086 1578 validated/Curated no pglB2 pilin glycosyl transferase B2 1a : Function from experimental evidences in the studied strain e : enzyme 5 : Inner membrane protein 2018-01-27 14:35:45 no 11349019, 17804791 Is involved in pilin glycosylation with a glyceramido acetamido trideoxyhexose residue. 2 vladimir 0.254119 0.2769 0.240177 0.228771 0.51711 0.48289 0.260456 0.21673 0.321293 0.201521 0.538023 0.461977 0.309886 0.203422 0.18251 0.304182 0.385932 0.614068 0.192015 0.410646 0.21673 0.180608 0.627376 0.372624 0.694578 59629.23 -0.240762 0.257143 0.474286 0.217143 0.118095 0.552381 0.447619 0.272381 0.137143 0.135238 5.958321 9.367619 NMV_1982 2192944 CDS +1 1905073 1905759 687 validated/Curated no putative HAD-like hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.-.-.- 2018-01-23 13:41:46 no Belongs to the group of Haloacid dehalogenase-like (HAD) hydrolases. 2 vladimir 0.251819 0.2955 0.209607 0.243086 0.505095 0.494905 0.253275 0.244541 0.270742 0.231441 0.515284 0.484716 0.340611 0.240175 0.148472 0.270742 0.388646 0.611354 0.161572 0.401747 0.209607 0.227074 0.611354 0.388646 0.674945 26146.505 -0.389474 0.254386 0.491228 0.219298 0.140351 0.513158 0.486842 0.267544 0.122807 0.144737 4.915199 8.868421 NMV_1983 2192945 CDS +3 1906200 1907405 1206 validated/Curated no pglC pilin glycosyl transferase PglC 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2020-04-20 20:31:44 no 10784055 Is involved in pilin glycosylation. 2 vladimir 0.259354 0.2985 0.261054 0.181122 0.559524 0.440476 0.270408 0.178571 0.372449 0.178571 0.55102 0.44898 0.316327 0.237245 0.188776 0.257653 0.42602 0.57398 0.191327 0.479592 0.221939 0.107143 0.701531 0.298469 0.744248 43394.74 -0.217136 0.329923 0.514066 0.191816 0.127877 0.549872 0.450128 0.268542 0.14578 0.122762 6.381828 9.445013 NMV_1984 2192946 CDS +2 1907453 1909363 1911 validated/Curated no pglD pilin glycosylation protein PglD 1b : Function from experimental evidences in the studied species ph : phenotype 5 : Inner membrane protein 2018-01-27 14:36:22 no 10784055 Belongs to the CapD family of polysaccharide biosynthesis proteins. Is involved in pilin glycosylation. 2 vladimir 0.22292 0.3333 0.236525 0.207221 0.569859 0.430141 0.265306 0.255887 0.3281 0.150706 0.583987 0.416013 0.240188 0.230769 0.175824 0.353218 0.406593 0.593407 0.163265 0.513344 0.205651 0.117739 0.718995 0.281005 0.64925 70813.325 0.19827 0.286164 0.465409 0.273585 0.092767 0.592767 0.407233 0.235849 0.125786 0.110063 7.662285 9.207547 NMV_1985 2192947 CDS +3 1909419 1910711 1293 validated/Curated no avtA valine-pyruvate aminotransferase (transaminase C; alanine-valine transaminase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.17 : Alanine ; 2.6.1.66 RXN0-5200$VALINE-PYRUVATE-AMINOTRANSFER-RXN ALANINE-VALINESYN-PWY 2018-01-27 14:36:47 no Catalyses the following reaction: L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine. 1 vladimir 0.242073 0.3171 0.252127 0.188708 0.569219 0.430781 0.266821 0.227378 0.359629 0.146172 0.587007 0.412993 0.308585 0.227378 0.155452 0.308585 0.382831 0.617169 0.150812 0.49652 0.241299 0.111369 0.737819 0.262181 0.714221 47056.025 0.003953 0.286047 0.502326 0.234884 0.116279 0.602326 0.397674 0.225581 0.109302 0.116279 5.293633 9.181395 NMV_1986 2192948 CDS -3 1910763 1911599 837 validated/Curated no 5'-3' exoribonuclease 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.13.- 2017-10-26 10:04:18 no 25871919 2 vladimir 0.218638 0.3082 0.291517 0.181601 0.599761 0.400239 0.204301 0.240143 0.397849 0.157706 0.637993 0.362007 0.297491 0.204301 0.229391 0.268817 0.433692 0.566308 0.154122 0.480287 0.247312 0.11828 0.727599 0.272401 0.673818 30318.245 -0.197122 0.330935 0.514388 0.215827 0.111511 0.557554 0.442446 0.28777 0.169065 0.118705 7.3395 9.776978 NMV_1988 2192950 CDS -2 1911907 1912308 402 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-16 16:18:15 no 3 vladimir 0.373134 0.1343 0.176617 0.31592 0.310945 0.689055 0.328358 0.134328 0.276119 0.261194 0.410448 0.589552 0.410448 0.149254 0.11194 0.328358 0.261194 0.738806 0.380597 0.119403 0.141791 0.358209 0.261194 0.738806 0.500695 15584.32 -0.070677 0.210526 0.398496 0.255639 0.142857 0.556391 0.443609 0.210526 0.075188 0.135338 4.385521 9.210526 NMV_1989 2192951 CDS -3 1912413 1912616 204 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-16 16:18:05 no 1 vladimir 0.230392 0.2549 0.333333 0.181373 0.588235 0.411765 0.176471 0.191176 0.411765 0.220588 0.602941 0.397059 0.352941 0.235294 0.25 0.161765 0.485294 0.514706 0.161765 0.338235 0.338235 0.161765 0.676471 0.323529 0.602962 7571.21 -0.692537 0.328358 0.507463 0.149254 0.089552 0.522388 0.477612 0.358209 0.149254 0.208955 4.671242 10.283582 NMV_1990 2192952 CDS -2 1912594 1912827 234 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-16 16:17:49 no 1 vladimir 0.282051 0.2607 0.282051 0.175214 0.542735 0.457265 0.217949 0.141026 0.5 0.141026 0.641026 0.358974 0.346154 0.205128 0.192308 0.25641 0.397436 0.602564 0.282051 0.435897 0.153846 0.128205 0.589744 0.410256 0.698874 8291 -0.177922 0.337662 0.480519 0.220779 0.064935 0.584416 0.415584 0.311688 0.103896 0.207792 4.342903 10.090909 NMNrRNA1913161D 19685117 misc_RNA +1 1913157 1913234 78 validated/Curated no NSE sRNA 1b : Function from experimental evidences in the studied species n : RNA 2 : Cytoplasmic 2018-01-28 18:50:23 22194974, 28334889 Neisseria sigma-E sRNA is a non-coding RNA found in the bacterial genus Neisseria. Seven genes were predicted to be regulated by NSE sRNA, including fur, nadC and a putative TetR family transcriptional regulator. vladimir NMV_1992 2192954 CDS +2 1913360 1916794 3435 validated/Curated no dnaE DNA polymerase III alpha subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:21:41 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 2 vladimir 0.238137 0.2926 0.278894 0.190393 0.57147 0.42853 0.247162 0.232314 0.361572 0.158952 0.593886 0.406114 0.313537 0.226201 0.168559 0.291703 0.39476 0.60524 0.153712 0.419214 0.30655 0.120524 0.725764 0.274236 0.696772 126921.415 -0.211538 0.27972 0.486014 0.215035 0.103147 0.571678 0.428322 0.259615 0.125 0.134615 5.290962 9.536713 NMNmisc_RNA1916856R 19685132 misc_RNA -1 1916858 1916964 107 validated/Curated no trans-activating crRNA (tracrRNA) 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 17:59:49 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. tracrRNA is a trans-activating small RNA required for maturation of precursor crRNA. vladimir NMV_1993 2192955 CDS +1 1917073 1920321 3249 validated/Curated no cas9 csn1 CRISPR/Cas system-associated endonuclease Cas9 (Csn1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 3.1.-.- 2018-01-27 14:38:17 no CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Following co-processing of tracrRNA and pre-crRNA by RNase III, dual-tracrRNA:crRNA guides Cas9 to cleave site-specifically cognate target DNA. 1 vladimir 0.305633 0.2536 0.235457 0.205294 0.489074 0.510926 0.266851 0.240997 0.333333 0.158818 0.574331 0.425669 0.367498 0.187442 0.180055 0.265005 0.367498 0.632502 0.282548 0.33241 0.192982 0.192059 0.525392 0.474608 0.665486 124389.895 -0.660259 0.231978 0.426987 0.204251 0.106285 0.488909 0.511091 0.341035 0.202403 0.138632 9.58062 9.549908 NMV_1994 2192956 CDS +1 1920388 1921302 915 validated/Curated no cas1 CRISPR/Cas system-associated Cas1 protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2018-01-27 14:38:42 no CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration. 2 vladimir 0.29071 0.3071 0.193443 0.208743 0.500546 0.499454 0.24918 0.311475 0.281967 0.157377 0.593443 0.406557 0.337705 0.222951 0.140984 0.298361 0.363934 0.636066 0.285246 0.386885 0.157377 0.170492 0.544262 0.455738 0.623355 34469.435 -0.193421 0.253289 0.414474 0.259868 0.108553 0.539474 0.460526 0.236842 0.138158 0.098684 8.746422 9.029605 NMV_1995 2192957 CDS +2 1921313 1921621 309 validated/Curated no cas2 CRISPR/Cas system-associated Cas2 protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2020-04-20 19:59:08 no CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas2 is present in majority of CRISPR/Cas systems along with Cas1. 1 vladimir 0.324159 0.2355 0.207951 0.232416 0.443425 0.556575 0.293578 0.238532 0.247706 0.220183 0.486239 0.513761 0.366972 0.155963 0.137615 0.33945 0.293578 0.706422 0.311927 0.311927 0.238532 0.137615 0.550459 0.449541 0.590424 12545.325 -0.225 0.212963 0.351852 0.25 0.101852 0.518519 0.481481 0.277778 0.185185 0.092593 9.778114 8.814815 NMNmisc_RNA1921693R 19685225 misc_RNA -1 1921693 1921750 58 validated/Curated no crRNA1 CRISPR RNA direct repeat element 1 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:11:14 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1921759R 19685232 misc_RNA -1 1921759 1921816 58 validated/Curated no crRNA2 CRISPR RNA direct repeat element 2 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:01:41 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1921825R 19685242 misc_RNA -1 1921825 1921882 58 validated/Curated no crRNA3 CRISPR RNA direct repeat element 3 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:02:12 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1921891R 19685251 misc_RNA -1 1921891 1921948 58 validated/Curated no crRNA4 CRISPR RNA direct repeat element 4 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:02:32 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1921957R 19685259 misc_RNA -1 1921957 1922014 58 validated/Curated no crRNA5 CRISPR RNA direct repeat element 5 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:02:48 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922023R 19685265 misc_RNA -1 1922023 1922080 58 validated/Curated no crRNA6 CRISPR RNA direct repeat element 6 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:03:06 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922089R 19685268 misc_RNA -1 1922089 1922146 58 validated/Curated no crRNA7 CRISPR RNA direct repeat element 7 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:03:28 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922155R 19685276 misc_RNA -1 1922155 1922212 58 validated/Curated no crRNA8 CRISPR RNA direct repeat element 8 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:03:47 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922221R 19685281 misc_RNA -1 1922221 1922278 58 validated/Curated no crRNA9 CRISPR RNA direct repeat element 9 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:04:09 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922287R 19685284 misc_RNA -1 1922287 1922344 58 validated/Curated no crRNA10 CRISPR RNA direct repeat element 10 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:04:28 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922353R 19685286 misc_RNA -1 1922353 1922410 58 validated/Curated no crRNA11 CRISPR RNA direct repeat element 11 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:04:43 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922419R 19685287 misc_RNA -1 1922419 1922476 58 validated/Curated no crRNA12 CRISPR RNA direct repeat element 12 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:05:05 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922485R 19685291 misc_RNA -1 1922485 1922542 58 validated/Curated no crRNA13 CRISPR RNA direct repeat element 13 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:06:00 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. This repeat is identical to crRNA14. vladimir NMNmisc_RNA1922551R 19685293 misc_RNA -1 1922551 1922608 58 validated/Curated no crRNA14 CRISPR RNA direct repeat element 14 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:06:50 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. This repeat is identical to crRNA13. vladimir NMNmisc_RNA1922617R 19685302 misc_RNA -1 1922617 1922674 58 validated/Curated no crRNA15 CRISPR RNA direct repeat element 15 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:07:26 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. This repeat is identical to crRNA16. vladimir NMNmisc_RNA1922683R 19685306 misc_RNA -1 1922683 1922740 58 validated/Curated no crRNA16 CRISPR RNA direct repeat element 16 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:08:11 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. This repeat is identical to crRNA15. vladimir NMNmisc_RNA1922749R 19685315 misc_RNA -1 1922749 1922806 58 validated/Curated no crRNA17 CRISPR RNA direct repeat element 17 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:08:30 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922815R 19685319 misc_RNA -1 1922815 1922872 58 validated/Curated no crRNA18 CRISPR RNA direct repeat element 18 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:08:47 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922881R 19685324 misc_RNA -1 1922881 1922938 58 validated/Curated no crRNA19 CRISPR RNA direct repeat element 19 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:09:03 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1922947R 19685327 misc_RNA -1 1922947 1923004 58 validated/Curated no crRNA20 CRISPR RNA direct repeat element 20 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:09:25 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1923013R 19685330 misc_RNA -1 1923013 1923070 58 validated/Curated no crRNA21 CRISPR RNA direct repeat element 21 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:09:46 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1923079R 19685332 misc_RNA -1 1923079 1923136 58 validated/Curated no crRNA22 CRISPR RNA direct repeat element 22 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:10:04 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1923145R 19685335 misc_RNA -1 1923145 1923202 58 validated/Curated no crRNA23 CRISPR RNA direct repeat element 23 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:10:31 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1923211R 19685338 misc_RNA -1 1923211 1923268 58 validated/Curated no crRNA24 CRISPR RNA direct repeat element 24 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:10:56 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmisc_RNA1923277R 19685340 misc_RNA -1 1923277 1923334 58 validated/Curated no crRNA25 CRISPR RNA direct repeat element 25 1a : Function from experimental evidences in the studied strain n : RNA 2 : Cytoplasmic 2018-01-28 18:11:09 23706818, 28334889 The CRISPR-cas system relies on the activity of short mature crRNAs that guide Cas9 protein (encoded by NMV_1993) to destroy invading DNA. vladimir NMNmiscRNA0172 54919405 misc_RNA +1 1923576 1923708 133 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:38:16 28334889 Function unknown. vladimir NMV_2002 2192964 fCDS -3 1923657 1924007 351 validated/Curated pseudo putative bacteriocin/pheromone secretion/processing ATP-binding protein (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 3.4.22.- 2018-01-23 11:36:42 no Belongs to the MEROPS cysteine peptidase family C39 and to the ATP-binding cassette ABC-type family. Is involved in the secretion and the proteolytic maturation of neighbouring bacteriocins/pheromones. 3 vladimir 0.299145 0.1681 0.236467 0.296296 0.404558 0.595442 0.273504 0.17094 0.34188 0.213675 0.512821 0.48718 0.34188 0.179487 0.119658 0.358974 0.299145 0.700855 0.282051 0.153846 0.247863 0.316239 0.401709 0.598291 0.524834 13124.485 0.011207 0.224138 0.431034 0.258621 0.12069 0.551724 0.448276 0.241379 0.094828 0.146552 4.586433 9.008621 NMV_2003 2192965 fCDS -1 1924010 1924786 777 validated/Curated pseudo putative bacteriocin/pheromone secretion/processing ATP-binding protein (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 5 : Inner membrane protein 3.4.22.- 2018-01-23 11:36:29 no Belongs to the MEROPS cysteine peptidase family C39 and to the ATP-binding cassette ABC-type family. Is involved in the secretion and the proteolytic maturation of neighbouring bacteriocins/pheromones. 3 vladimir 0.222632 0.1734 0.253383 0.350554 0.426814 0.573186 0.191882 0.206642 0.276753 0.324723 0.483395 0.516605 0.214022 0.202952 0.173432 0.409594 0.376384 0.623616 0.261993 0.110701 0.309963 0.317343 0.420664 0.579336 0.56015 30856.445 0.431852 0.244444 0.433333 0.311111 0.12963 0.614815 0.385185 0.203704 0.133333 0.07037 9.658058 9.1 NMV_2005 2192967 CDS -1 1925003 1925338 336 validated/Curated no putative bacteriocin/pheromone 3 : Putative function from multiple computational evidences f : factor 10 : Secreted 2018-01-27 14:39:40 no Could be a pheromone or a bacteriocin toxic to closely related bacteria. Processing of the N-terminal region up to the GA cleavage motif occurs together with export by a neighbouring ABC transporter. 3 vladimir 0.235119 0.1310 0.330357 0.303571 0.46131 0.53869 0.214286 0.089286 0.5625 0.133929 0.651786 0.348214 0.1875 0.214286 0.348214 0.25 0.5625 0.4375 0.303571 0.089286 0.080357 0.526786 0.169643 0.830357 0.491105 10305.88 0.335135 0.522523 0.684685 0.225225 0.063063 0.738739 0.261261 0.117117 0.036036 0.081081 4.164848 9.09009 NMV_2007 2192969 CDS -3 1925331 1925750 420 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-04-16 16:13:46 no 3 vladimir 0.361905 0.0952 0.092857 0.45 0.188095 0.811905 0.442857 0.071429 0.135714 0.35 0.207143 0.792857 0.264286 0.135714 0.057143 0.542857 0.192857 0.807143 0.378571 0.078571 0.085714 0.457143 0.164286 0.835714 0.425765 16533.43 1.093525 0.158273 0.338129 0.374101 0.215827 0.661871 0.338129 0.115108 0.093525 0.021583 9.792534 7.848921 NMV_2009 2192971 CDS -3 1925931 1926266 336 validated/Curated no putative bacteriocin/pheromone 3 : Putative function from multiple computational evidences f : factor 10 : Secreted 2018-01-27 14:39:59 no Could be a pheromone or a bacteriocin toxic to closely related bacteria. Processing of the N-terminal region up to the GA cleavage motif occurs together with export by a neighbouring ABC transporter. 3 vladimir 0.303571 0.1339 0.270833 0.291667 0.404762 0.595238 0.276786 0.080357 0.455357 0.1875 0.535714 0.464286 0.258929 0.258929 0.258929 0.223214 0.517857 0.482143 0.375 0.0625 0.098214 0.464286 0.160714 0.839286 0.424228 11163.8 -0.045946 0.45045 0.648649 0.198198 0.081081 0.630631 0.369369 0.171171 0.063063 0.108108 4.31855 9.162162 NMV_2010 2192972 CDS -3 1926288 1926464 177 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-04-16 16:13:17 no 3 vladimir 0.350282 0.0960 0.169492 0.384181 0.265537 0.734463 0.38983 0.118644 0.237288 0.254237 0.355932 0.644068 0.305085 0.084746 0.169492 0.440678 0.254237 0.745763 0.355932 0.084746 0.101695 0.457627 0.186441 0.813559 0.486283 6707.695 0.567241 0.206897 0.362069 0.310345 0.206897 0.672414 0.327586 0.189655 0.12069 0.068966 7.022484 8.637931 NMV_2011 2192973 fCDS -2 1926508 1927215 708 validated/Curated pseudo conserved hypothetical protein (pseudogene part 2) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:34:36 no 3 vladimir 0.351695 0.1441 0.186441 0.317797 0.330508 0.669492 0.364407 0.182203 0.245763 0.207627 0.427966 0.572034 0.364407 0.165254 0.135593 0.334746 0.300847 0.699153 0.326271 0.084746 0.177966 0.411017 0.262712 0.737288 0.509225 27327.43 -0.259574 0.187234 0.429787 0.221277 0.13617 0.548936 0.451064 0.234043 0.110638 0.123404 5.099556 9.510638 NMV_2012 2192974 fCDS -2 1927300 1927656 357 validated/Curated pseudo conserved hypothetical protein (pseudogene part 1) 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-06-18 16:34:49 no 3 vladimir 0.35014 0.1401 0.184874 0.32493 0.32493 0.67507 0.302521 0.168067 0.277311 0.252101 0.445378 0.554622 0.428571 0.159664 0.12605 0.285714 0.285714 0.714286 0.319328 0.092437 0.151261 0.436975 0.243697 0.756303 0.585119 14189.675 -0.566949 0.177966 0.389831 0.186441 0.186441 0.508475 0.491525 0.29661 0.169492 0.127119 8.952995 9.5 NMV_2014 2192976 CDS -1 1927853 1928344 492 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-16 16:05:30 no 3 vladimir 0.426829 0.1402 0.211382 0.221545 0.351626 0.648374 0.329268 0.189024 0.335366 0.146341 0.52439 0.47561 0.530488 0.121951 0.103659 0.243902 0.22561 0.77439 0.420732 0.109756 0.195122 0.27439 0.304878 0.695122 0.608704 19719.62 -1.149693 0.141104 0.294479 0.159509 0.116564 0.404908 0.595092 0.392638 0.202454 0.190184 7.98069 9.828221 NMV_2015 2192977 CDS -3 1928712 1929029 318 validated/Curated partial truncated putative RepB-like initiator protein (internal fragment corresponding to a third of the protein) 5 : Unknown function f : factor 1 : Unknown 2008-06-12 16:35:12 no 3 vladimir 0.321429 0.1488 0.214286 0.315476 0.363095 0.636905 0.321429 0.169643 0.276786 0.232143 0.446429 0.553571 0.383929 0.142857 0.169643 0.303571 0.3125 0.6875 0.258929 0.133929 0.196429 0.410714 0.330357 0.669643 0.502789 13375.83 -0.593694 0.207207 0.351351 0.189189 0.162162 0.486486 0.513514 0.288288 0.162162 0.126126 9.395729 10 NMV_2016 2192978 CDS -2 1929028 1929279 252 validated/Curated partial truncated putative RepB-like initiator protein (internal fragment corresponding to 20% of the protein) 5 : Unknown function f : factor 1 : Unknown 2008-06-12 16:35:33 no 3 vladimir 0.365385 0.1442 0.173077 0.317308 0.317308 0.682692 0.336538 0.163462 0.240385 0.259615 0.403846 0.596154 0.413462 0.105769 0.115385 0.365385 0.221154 0.778846 0.346154 0.163462 0.163462 0.326923 0.326923 0.673077 0.454877 12228.73 -0.13301 0.174757 0.378641 0.262136 0.184466 0.543689 0.456311 0.252427 0.15534 0.097087 8.686287 9.145631 NMV_2017 2192979 CDS -2 1929490 1930422 933 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-16 15:41:38 no 2 vladimir 0.227224 0.3130 0.257235 0.202572 0.570204 0.429796 0.237942 0.26045 0.308682 0.192926 0.569132 0.430868 0.270096 0.254019 0.205788 0.270096 0.459807 0.540193 0.173633 0.424437 0.257235 0.144695 0.681672 0.318328 0.538673 34994.465 -0.320323 0.3 0.493548 0.183871 0.129032 0.551613 0.448387 0.241935 0.132258 0.109677 7.202782 9.977419 NMV_2018 2192980 CDS -2 1930492 1932648 2157 validated/Curated no putative TonB-dependent receptor 3 : Putative function from multiple computational evidences t : transporter 7 : Outer membrane protein 2018-01-27 14:41:00 no Is an outer-membrane active-transport protein, which interacts with the transperiplasmic protein TonB through a conserved sequence, the ''Ton-box''. Interaction with TonB couples the energy of the proton motive force of the inner-membrane to drive an outer-membrane transport cycle. 2 vladimir 0.250346 0.3084 0.259567 0.181651 0.568004 0.431996 0.283541 0.20332 0.348548 0.164592 0.551867 0.448133 0.322268 0.24343 0.206086 0.228216 0.449516 0.550484 0.145228 0.478562 0.224066 0.152144 0.702628 0.297372 0.733672 78610.815 -0.462742 0.34903 0.558172 0.160665 0.126039 0.537396 0.462604 0.225762 0.137119 0.088643 9.366463 9.534626 NMV_2019 2192981 CDS +1 1932808 1933467 660 validated/Curated no putative phosphatase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.3.- 2018-01-22 15:52:02 no Belongs to the HAD hydrolase, subfamily IA. 2 vladimir 0.2 0.3576 0.266667 0.175758 0.624242 0.375758 0.213636 0.259091 0.381818 0.145455 0.640909 0.359091 0.240909 0.313636 0.190909 0.254545 0.504545 0.495455 0.145455 0.5 0.227273 0.127273 0.727273 0.272727 0.655504 23337.72 0.003653 0.365297 0.570776 0.196347 0.105023 0.630137 0.369863 0.210046 0.100457 0.109589 5.154671 9.60274 NMV_2020 2192982 CDS -2 1933555 1934523 969 validated/Curated no ispH lytB 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.19 : Isoprenoid biosynthesis ; 1.17.7.4 ISPH2-RXN$RXN0-884 NONMEVIPP-PWY 2018-01-19 10:25:51 no Catalyses the following reaction in the mevalonate pathway: isopentenyl diphosphate + NAD(P)(+) + H(2)O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. 1 vladimir 0.24355 0.2590 0.314757 0.182663 0.573787 0.426213 0.235294 0.198142 0.442724 0.123839 0.640867 0.359133 0.306502 0.219814 0.188854 0.28483 0.408669 0.591331 0.188854 0.359133 0.312694 0.139319 0.671827 0.328173 0.63657 35248.835 -0.186025 0.28882 0.537267 0.242236 0.07764 0.552795 0.447205 0.295031 0.152174 0.142857 5.984169 10.142857 NMV_2021 2192983 CDS -2 1934542 1935078 537 validated/Curated no lspA lsp lipoprotein signal peptidase (prolipoprotein signal peptidase; signal peptidase II; SPase II) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 1.6.10 : Lipoprotein ; 2.3.5 : Export, signal peptide cleavage ; 3.4.23.36 3.4.23.36-RXN 2020-02-19 14:11:17 no Catalyses the release of signal peptides from bacterial membrane prolipoproteins. Hydrolyses -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. 2 vladimir 0.191321 0.2327 0.282051 0.293886 0.514793 0.485207 0.213018 0.147929 0.360947 0.278107 0.508876 0.491124 0.242604 0.207101 0.177515 0.372781 0.384615 0.615385 0.118343 0.343195 0.307692 0.230769 0.650888 0.349112 0.690419 18776.015 0.519048 0.285714 0.52381 0.285714 0.172619 0.654762 0.345238 0.166667 0.10119 0.065476 9.071342 8.607143 NMV_2022 2192984 CDS -1 1936154 1938943 2790 validated/Curated no ileS isoleucine-tRNA ligase (isoleucyl-tRNA synthetase; IleRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.5 ISOLEUCINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:54:51 no Catalyses the attachment of isoleucine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.246595 0.2860 0.269176 0.198208 0.555197 0.444803 0.233333 0.205376 0.382796 0.178495 0.588172 0.411828 0.326882 0.225806 0.192473 0.254839 0.41828 0.58172 0.17957 0.426882 0.232258 0.16129 0.65914 0.34086 0.775406 104433.62 -0.332616 0.29817 0.482239 0.199139 0.130248 0.552207 0.447793 0.293864 0.14747 0.146394 5.603172 9.639397 NMV_2023 2192985 CDS -2 1939084 1940004 921 validated/Curated no ribF riboflavin biosynthesis protein RibF [includes: riboflavin kinase (flavokinase) and FMN adenylyltransferase (FAD pyrophosphorylase; FAD synthetase)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN ; 2.7.7.2, 2.7.1.26 FADSYN-RXN$RIBOFLAVINKIN-RXN RIBOSYN2-PWY 2018-01-27 14:42:24 no Is a bifunctional enzyme having both ATP:riboflavin 5'-phospho transferase and ATP:FMN-adenylyltransferase activities. It catalyses the 5'-phosphorylation of riboflavin to FMN and the adenylylation of FMN to FAD. 1 vladimir 0.224756 0.3029 0.269273 0.20304 0.572204 0.427796 0.205212 0.28013 0.368078 0.14658 0.648208 0.351792 0.28013 0.19544 0.228013 0.296417 0.423453 0.576547 0.188925 0.433225 0.211726 0.166124 0.644951 0.355049 0.589871 34094.755 -0.233333 0.284314 0.490196 0.222222 0.117647 0.562092 0.437908 0.281046 0.166667 0.114379 9.127525 9.676471 NMV_2026 2192988 CDS -1 1940531 1941826 1296 validated/Curated no tyrS tyrosine-tRNA ligase (tyrosyl-tRNA synthetase; TyrRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.1 TYROSINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:55:50 no Catalyses the attachment of tyrosine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.251543 0.3194 0.246914 0.182099 0.566358 0.433642 0.256944 0.215278 0.368056 0.159722 0.583333 0.416667 0.319444 0.226852 0.175926 0.277778 0.402778 0.597222 0.178241 0.516204 0.196759 0.108796 0.712963 0.287037 0.799241 47268.69 -0.204872 0.315545 0.49652 0.211137 0.106729 0.545244 0.454756 0.2529 0.12761 0.12529 5.69471 8.976798 NMV_2027 2192989 CDS -2 1941889 1943757 1869 validated/Curated no putative inner-membrane acyltransferase 3 : Putative function from multiple computational evidences e : enzyme 5 : Inner membrane protein 2.3.1.- 2020-04-20 21:34:22 no Belongs to the acyltransferase 3 family. 1 vladimir 0.203317 0.2964 0.2397 0.260567 0.536116 0.463884 0.191011 0.23756 0.300161 0.271268 0.537721 0.462279 0.260032 0.266453 0.158909 0.314607 0.425361 0.574639 0.158909 0.385233 0.260032 0.195827 0.645265 0.354735 0.66732 70218.055 0.161093 0.300643 0.461415 0.221865 0.173633 0.635048 0.364952 0.205788 0.128617 0.07717 9.112251 8.998392 NMV_2028 2192990 CDS -3 1944123 1945214 1092 validated/Curated no putative ribosome-binding ATPase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 14:43:55 no ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. 1 vladimir 0.250916 0.2839 0.276557 0.188645 0.56044 0.43956 0.228022 0.186813 0.458791 0.126374 0.645604 0.354396 0.326923 0.211538 0.153846 0.307692 0.365385 0.634615 0.197802 0.453297 0.217033 0.131868 0.67033 0.32967 0.785542 39358.43 -0.056474 0.275482 0.523416 0.242424 0.077135 0.589532 0.410468 0.286501 0.123967 0.162534 4.798027 9.694215 NMV_2029 2192991 CDS -3 1945329 1947005 1677 validated/Curated no fhs formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase; FHS; FTHFS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 6.3.4.3 FORMATETHFLIG-RXN$RXN-6283 1CMET2-PWY$PWY-1722$PWY-2161$PWY-2201 2020-02-21 16:16:36 no Is one of the enzymes participating in the transfer of one-carbon units, a central element of various biosynthetic pathways. It catalyses the following reaction: ATP + formate + tetrahydrofolate <=> ADP + phosphate + 10-formyltetrahydrofolate. 2 vladimir 0.237925 0.2850 0.275492 0.20155 0.560525 0.439475 0.259392 0.173524 0.429338 0.137746 0.602862 0.397138 0.298748 0.234347 0.16458 0.302326 0.398927 0.601073 0.155635 0.447227 0.232558 0.16458 0.679785 0.320215 0.798093 59209.695 0.06147 0.31362 0.555556 0.241935 0.078853 0.614695 0.385305 0.24552 0.12724 0.11828 6.006172 9.308244 NMV_2030 2192992 CDS +3 1947180 1947611 432 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-16 15:37:34 no 1 vladimir 0.185185 0.2847 0.277778 0.252315 0.5625 0.4375 0.215278 0.180556 0.361111 0.243056 0.541667 0.458333 0.166667 0.263889 0.180556 0.388889 0.444444 0.555556 0.173611 0.409722 0.291667 0.125 0.701389 0.298611 0.670016 15314.38 0.846853 0.370629 0.531469 0.293706 0.13986 0.699301 0.300699 0.097902 0.062937 0.034965 9.600914 8.097902 NMV_2031 2192993 CDS -1 1947857 1948552 696 validated/Curated no murU N-acetylmuramate alpha-1-phosphate uridylyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 2.7.7.- 2018-01-22 20:13:26 no 23831760 Catalyses the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P. Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. 1 vladimir 0.195402 0.2744 0.327586 0.202586 0.602012 0.397988 0.198276 0.24569 0.409483 0.146552 0.655172 0.344828 0.24569 0.25431 0.224138 0.275862 0.478448 0.521552 0.142241 0.323276 0.349138 0.185345 0.672414 0.327586 0.602484 24448.88 -0.02987 0.337662 0.558442 0.225108 0.090909 0.632035 0.367965 0.21645 0.108225 0.108225 5.48867 9.341991 NMV_2032 2192994 CDS -1 1948568 1949068 501 validated/Curated no putative 4-hydroxyphenylacetate 3-monooxygenase, reductase component (4-HPA 3-monooxygenase small component; flavin:NADH reductase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 14:46:10 no Catalyses the first step (hydroxylation at the 3-position) in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. These reductases catalyse the reduction of free flavins by NADPH. The flavin is then utilised by the large subunit of the monooxygenase. 1 vladimir 0.227545 0.2595 0.291417 0.221557 0.550898 0.449102 0.251497 0.239521 0.347305 0.161677 0.586826 0.413174 0.275449 0.227545 0.203593 0.293413 0.431138 0.568862 0.155689 0.311377 0.323353 0.209581 0.634731 0.365269 0.565978 18448.465 -0.040361 0.319277 0.487952 0.216867 0.144578 0.572289 0.427711 0.26506 0.156627 0.108434 6.574303 9.879518 NMV_2033 2192995 CDS -1 1949183 1949623 441 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-27 14:46:20 no Belongs to the MarR family of transcriptional regulators. 1 vladimir 0.265306 0.2426 0.269841 0.222222 0.512472 0.487528 0.278912 0.285714 0.319728 0.115646 0.605442 0.394558 0.346939 0.190476 0.142857 0.319728 0.333333 0.666667 0.170068 0.251701 0.346939 0.231293 0.598639 0.401361 0.636925 16612.565 -0.247945 0.226027 0.390411 0.280822 0.047945 0.506849 0.493151 0.294521 0.136986 0.157534 5.144203 9.308219 NMV_2034 2192996 CDS -1 1949966 1950475 510 validated/Curated no putative membrane-associated thioredoxin 3 : Putative function from multiple computational evidences f : factor 11 : Membrane 2018-01-27 14:46:39 no Thioredoxins are small proteins, which participate in various redox reactions via the reversible oxidation of an active center disulfide bond. They exist in either a reduced form or an oxidised form where the two cysteine residues are linked in an intramolecular disulfide bond. 1 vladimir 0.17451 0.2059 0.360784 0.258824 0.566667 0.433333 0.194118 0.170588 0.4 0.235294 0.570588 0.429412 0.2 0.229412 0.247059 0.323529 0.476471 0.523529 0.129412 0.217647 0.435294 0.217647 0.652941 0.347059 0.546203 18321.63 0.270414 0.337278 0.556213 0.260355 0.112426 0.650888 0.349112 0.201183 0.130178 0.071006 9.892509 9.047337 NMV_tRNA_38 2194853 tRNA -1 1950554 1950629 76 validated/Curated no Lys tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:58:28 no tRNA Lys anticodon TTT. vladimir NMV_2036 2192998 CDS +3 1950792 1951919 1128 validated/Curated no mrp iron-sulfur cluster carrier protein 2a : Function from experimental evidences in other organisms f : factor 1 : Unknown 2020-02-19 14:11:41 no Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyse ATP. 2 vladimir 0.240741 0.3417 0.244444 0.173148 0.586111 0.413889 0.266667 0.247222 0.383333 0.102778 0.630556 0.369444 0.269444 0.252778 0.161111 0.316667 0.413889 0.586111 0.186111 0.525 0.188889 0.1 0.713889 0.286111 0.679623 38374.42 0.048468 0.311978 0.559889 0.250696 0.072423 0.576602 0.423398 0.220056 0.108635 0.111421 5.354836 9.058496 NMV_2037 2192999 CDS +1 1952695 1955772 3078 validated/Curated no pilC1 type IV pilus-associated protein PilC1 1a : Function from experimental evidences in the studied strain f : factor 8 : Outer membrane-associated 6.5 : Pilus ; 2020-04-25 14:48:13 no 15103324, 1671354, 7909606, 9844000 Outer membrane protein, required for pilus biogenesis. In N. meningitidis, there are two pilC alleles. PilC1, but not PilC2, has an additional function since it also promotes adhesion to host cells. 1 vladimir 0.281352 0.2495 0.261858 0.207277 0.511371 0.488629 0.339181 0.160819 0.341131 0.158869 0.501949 0.498051 0.338207 0.208577 0.218324 0.234893 0.426901 0.573099 0.166667 0.379142 0.226121 0.22807 0.605263 0.394737 0.634451 112127.31 -0.584195 0.324878 0.566829 0.182439 0.09561 0.498537 0.501463 0.257561 0.148293 0.109268 9.356743 9.193171 NMV_2040 2193002 CDS +3 1958040 1959173 1134 validated/Curated no carA carbamoyl-phosphate synthase small chain (carbamoyl-phosphate synthetase glutamine chain) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 1.5.2.2 : Pyrimidine biosynthesis ; 6.3.5.5 CARBPSYN-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$PWY-5686 2018-01-29 22:39:59 no Catalyses the following reaction: 2 ATP + L-glutamine + CO(2) + H(2)O <=> 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. 2 vladimir 0.242504 0.3307 0.244268 0.18254 0.574956 0.425044 0.269841 0.21164 0.367725 0.150794 0.579365 0.420635 0.298942 0.243386 0.185185 0.272487 0.428571 0.571429 0.15873 0.537037 0.179894 0.124339 0.716931 0.283069 0.782388 40647.38 -0.135279 0.342175 0.551724 0.214854 0.106101 0.554377 0.445623 0.230769 0.114058 0.116711 5.370644 9.222812 NMV_2041 2193003 CDS +3 1959219 1959356 138 validated/Curated partial truncated putative dioxygenase (N-terminal third of the protein) 5 : Unknown function e : enzyme 1 : Unknown 2008-04-16 15:32:29 no 2 vladimir 0.282609 0.2101 0.231884 0.275362 0.442029 0.557971 0.304348 0.152174 0.369565 0.173913 0.521739 0.478261 0.326087 0.173913 0.130435 0.369565 0.304348 0.695652 0.217391 0.304348 0.195652 0.282609 0.5 0.5 0.669979 5041.63 0.268889 0.266667 0.488889 0.288889 0.088889 0.555556 0.444444 0.266667 0.111111 0.155556 4.647316 9.466667 NMV_2042 2193004 CDS +3 1959918 1960307 390 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-16 15:31:56 no 1 vladimir 0.287179 0.2615 0.266667 0.184615 0.528205 0.471795 0.253846 0.292308 0.3 0.153846 0.592308 0.407692 0.369231 0.184615 0.169231 0.276923 0.353846 0.646154 0.238462 0.307692 0.330769 0.123077 0.638462 0.361538 0.596126 14947.57 -0.515504 0.232558 0.403101 0.209302 0.116279 0.511628 0.488372 0.271318 0.162791 0.108527 8.834328 10.224806 NMV_2043 2193005 CDS +2 1961525 1962166 642 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-16 15:31:43 no 3 vladimir 0.378505 0.1355 0.160436 0.325545 0.29595 0.70405 0.406542 0.126168 0.257009 0.21028 0.383178 0.616822 0.425234 0.182243 0.126168 0.266355 0.308411 0.691589 0.303738 0.098131 0.098131 0.5 0.196262 0.803738 0.5295 25130.44 -0.719249 0.192488 0.450704 0.169014 0.150235 0.469484 0.530516 0.295775 0.159624 0.13615 8.952568 9.441315 NMV_2044 2193006 CDS +3 1962195 1965410 3216 validated/Curated no carB carbamoyl-phosphate synthase large chain (carbamoyl-phosphate synthetase ammonia chain) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 1.5.2.2 : Pyrimidine biosynthesis ; 6.3.5.5 CARBPSYN-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$PWY-5686 2018-01-29 22:39:21 no Catalyses the following reaction: 2 ATP + L-glutamine + CO(2) + H(2)O <=> 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. 2 vladimir 0.243159 0.2889 0.276119 0.191853 0.564988 0.435012 0.249067 0.201493 0.392724 0.156716 0.594216 0.405784 0.306903 0.228545 0.175373 0.289179 0.403918 0.596082 0.173507 0.436567 0.260261 0.129664 0.696828 0.303172 0.768977 117358.23 -0.175257 0.297852 0.515406 0.22409 0.084034 0.556489 0.443511 0.261438 0.122316 0.139122 5.136299 9.731092 NMV_2045 2193007 CDS -1 1965638 1966537 900 validated/Curated no crgA HTH-type transcriptional regulator CrgA 1a : Function from experimental evidences in the studied strain r : regulator 2 : Cytoplasmic 2018-01-27 15:11:18 no 10698947, 11952904, 12670987, 15255902, 15866928 Is a LysR family transcriptional regulator, which is transiently induced upon cell contact. 1 vladimir 0.25 0.2578 0.257778 0.234444 0.515556 0.484444 0.22 0.25 0.346667 0.183333 0.596667 0.403333 0.29 0.223333 0.18 0.306667 0.403333 0.596667 0.24 0.3 0.246667 0.213333 0.546667 0.453333 0.61042 33072.55 -0.077592 0.297659 0.48495 0.247492 0.093645 0.545151 0.454849 0.250836 0.12709 0.123746 5.677834 9.401338 NMV_2046 2193008 CDS +3 1966776 1967354 579 validated/Curated no mdaB NADPH:quinone oxidoreductase MdaB (modulator of drug activity B) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.5.10 RXN0-271 2020-04-21 16:37:15 no 1 vladimir 0.29361 0.2073 0.264249 0.234888 0.471503 0.528497 0.264249 0.165803 0.367876 0.202073 0.533679 0.466321 0.373057 0.160622 0.176166 0.290155 0.336788 0.663212 0.243523 0.295337 0.248705 0.212435 0.544041 0.455959 0.677404 21758.915 -0.331771 0.255208 0.458333 0.208333 0.171875 0.5625 0.4375 0.28125 0.15625 0.125 6.113945 9.458333 NMV_2048 2193010 CDS -2 1967725 1968765 1041 validated/Curated no queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase (queuosine biosynthesis protein QueA) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.4.99.17 RXN0-1342 PWY-6700 2018-01-23 13:59:04 no It is part of the queuosine biosynthesis pathway. Catalyses the following reaction: S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA <=> L-methionine + adenine + epoxyqueuosine(34) in tRNA. 1 vladimir 0.208453 0.2613 0.307397 0.222863 0.568684 0.431316 0.204611 0.233429 0.412104 0.149856 0.645533 0.354467 0.288184 0.224784 0.195965 0.291066 0.420749 0.579251 0.132565 0.325648 0.314121 0.227666 0.639769 0.360231 0.666325 38198.035 -0.212139 0.297688 0.511561 0.213873 0.118497 0.569364 0.430636 0.280347 0.150289 0.130058 6.293495 9.83526 NMV_2050 2193012 CDS +2 1969121 1969576 456 validated/Curated no accB biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; ACETYL-COA-CARBOXYLTRANSFER-RXN PWY-4381 2020-04-22 16:59:46 no Is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyses the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. 2 vladimir 0.243421 0.3158 0.263158 0.177632 0.578947 0.421053 0.230263 0.171053 0.480263 0.118421 0.651316 0.348684 0.256579 0.361842 0.105263 0.276316 0.467105 0.532895 0.243421 0.414474 0.203947 0.138158 0.618421 0.381579 0.757686 15678.5 0.155629 0.344371 0.582781 0.225166 0.039735 0.642384 0.357616 0.231788 0.092715 0.139073 4.67498 9.642384 NMV_2051 2193013 CDS +3 1969689 1971050 1362 validated/Curated no accC biotin carboxylase (A subunit of acetyl-CoA carboxylase; ACC) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; 6.3.4.14 ACETYL-COA-CARBOXYLTRANSFER-RXN$BIOTIN-CARBOXYL-RXN PWY-4381$PWY0-1264 2018-01-27 15:13:00 no Is a component of the acetyl coenzyme A carboxylase complex. First, biotin carboxylase catalyses the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. 2 vladimir 0.246696 0.3209 0.255507 0.176946 0.576358 0.423642 0.231278 0.226872 0.411894 0.129956 0.638767 0.361233 0.328194 0.209251 0.187225 0.27533 0.396476 0.603524 0.180617 0.526432 0.167401 0.125551 0.693833 0.306167 0.782065 49625.82 -0.199338 0.286976 0.496689 0.216336 0.101545 0.587196 0.412804 0.284768 0.145695 0.139073 5.753029 9.825607 NMV_2052 2193014 CDS +2 1971311 1972198 888 validated/Curated no prmA ribosomal protein L11 methyltransferase (L11 Mtase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.- RXN0-5419 2018-01-22 19:01:59 no Is required for the methylation of ribosomal protein L11. 2 vladimir 0.243243 0.3468 0.251126 0.158784 0.597973 0.402027 0.209459 0.246622 0.415541 0.128378 0.662162 0.337838 0.310811 0.236486 0.192568 0.260135 0.429054 0.570946 0.209459 0.557432 0.14527 0.087838 0.702703 0.297297 0.70935 31931.5 -0.196271 0.322034 0.515254 0.216949 0.081356 0.572881 0.427119 0.230508 0.081356 0.149153 4.344826 9.518644 NMV_2053 2193015 CDS +1 1972216 1972779 564 validated/Curated no orn oligoribonuclease 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.4 : RNA degradation ; 3.1.-.- 3.1.13.3-RXN 2018-01-22 20:37:50 no Is a 3'-to-5' exoribonuclease, specific for small oligoribonucleotides. 1 vladimir 0.278369 0.2819 0.251773 0.187943 0.533688 0.466312 0.271277 0.239362 0.329787 0.159574 0.569149 0.430851 0.37766 0.196809 0.148936 0.276596 0.345745 0.654255 0.18617 0.409574 0.276596 0.12766 0.68617 0.31383 0.676767 21757.78 -0.59893 0.224599 0.449198 0.208556 0.112299 0.465241 0.534759 0.326203 0.160428 0.165775 5.364662 10.149733 NMV_2054 2193016 CDS -2 1973185 1974468 1284 validated/Curated no hemL glutamate-1-semialdehyde 2,1-aminomutase (GSA; glutamate-1-semialdehyde aminotransferase; GSA-AT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.12 : Heme, porphyrin ; 5.4.3.8 GSAAMINOTRANS-RXN PWY-5188 2018-01-27 15:13:31 no Catalyses the conversion of (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the second step of porphyrin biosynthesis by the C5 pathway. 2 vladimir 0.207165 0.2967 0.283489 0.212617 0.580218 0.419782 0.233645 0.17757 0.432243 0.156542 0.609813 0.390187 0.240654 0.261682 0.200935 0.296729 0.462617 0.537383 0.147196 0.450935 0.21729 0.184579 0.668224 0.331776 0.750893 45369.02 0.111241 0.360656 0.545667 0.210773 0.11007 0.627635 0.372365 0.222482 0.112412 0.11007 5.653908 9.672131 NMV_2056 2193018 CDS +2 1975301 1976629 1329 validated/Curated no miaB tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.8.4.3 RXN0-5063 2018-01-27 15:15:07 no Catalyses the methylthiolation of N6-(dimethylallyl)adenosine (i6A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms2i6A) at position 37 in tRNAs that read codons beginning with uridine. 2 vladimir 0.255831 0.3251 0.234763 0.184349 0.559819 0.440181 0.264108 0.227991 0.352144 0.155756 0.580135 0.419865 0.320542 0.200903 0.171558 0.306998 0.37246 0.62754 0.182844 0.546275 0.180587 0.090293 0.726862 0.273138 0.806778 49617.965 -0.233484 0.257919 0.479638 0.235294 0.090498 0.529412 0.470588 0.28733 0.138009 0.149321 5.28701 9.723982 NMV_2057 2193019 CDS -1 1976714 1978627 1914 validated/Curated no dxs 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.6 : Pyridoxine (vitamin B6) ; 1.5.3.19 : Isoprenoid biosynthesis ; 2.2.1.7 DXS-RXN NONMEVIPP-PWY$PYRIDOXSYN-PWY 2020-02-24 16:08:50 no Catalyses the following reaction: pyruvate + D-glyceraldehyde 3-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + CO(2). 2 vladimir 0.225705 0.2957 0.287879 0.1907 0.583595 0.416405 0.221003 0.227273 0.412226 0.139498 0.639498 0.360502 0.30094 0.22884 0.18652 0.283699 0.415361 0.584639 0.155172 0.431034 0.26489 0.148903 0.695925 0.304075 0.701159 68738.82 -0.140502 0.307692 0.538462 0.22763 0.089482 0.583987 0.416013 0.260597 0.138148 0.122449 6.170982 9.536892 NMV_2058 2193020 CDS -1 1978712 1979629 918 validated/Curated no xerC tyrosine recombinase XerC 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.3 : DNA recombination ; 2018-01-27 15:15:48 no XerC and the closely related XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. XerC and XerD interact with cell division protein FtsK. 1 vladimir 0.203704 0.2865 0.335512 0.174292 0.622004 0.377996 0.179739 0.316993 0.352941 0.150327 0.669935 0.330065 0.316993 0.215686 0.215686 0.251634 0.431373 0.568627 0.114379 0.326797 0.437909 0.120915 0.764706 0.235294 0.61754 34482.86 -0.559344 0.268852 0.462295 0.206557 0.108197 0.521311 0.478689 0.301639 0.180328 0.121311 9.379066 9.790164 NMV_2059 2193021 CDS +3 1979823 1980887 1065 validated/Curated no fba fructose-bisphosphate aldolase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 4.1.2.13 F16ALDOLASE-RXN$RXN-8631 ANAGLYCOLYSIS-PWY$GLUCONEO-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-31 14:56:39 no Catalyses the following reaction: D-fructose 1,6-bisphosphate <=> glycerone phosphate + D-glyceraldehyde 3-phosphate. 2 vladimir 0.25446 0.3061 0.25446 0.184977 0.560563 0.439437 0.239437 0.211268 0.408451 0.140845 0.619718 0.380282 0.321127 0.222535 0.169014 0.287324 0.391549 0.608451 0.202817 0.484507 0.185915 0.126761 0.670423 0.329577 0.809399 38414.055 -0.172599 0.299435 0.536723 0.228814 0.09322 0.562147 0.437853 0.254237 0.129944 0.124294 5.664589 9.776836 NMV_2060 2193022 CDS +1 1981045 1981866 822 validated/Curated no factor H-binding lipoprotein 1b : Function from experimental evidences in the studied species m : membrane component 8 : Outer membrane-associated 2018-01-27 15:17:14 no 12642606, 16407174, 16785547 Is one of the antigens in the Bexsero vaccine (GNA1870) that induces cross-reactive bactericidal antibodies against a number of N. meningitidis strains. The proteins binds the complement regulatory protein factor H and enhances meningococcal serum resistance. 2 vladimir 0.289286 0.2917 0.253571 0.165476 0.545238 0.454762 0.292857 0.196429 0.389286 0.121429 0.585714 0.414286 0.360714 0.214286 0.185714 0.239286 0.4 0.6 0.214286 0.464286 0.185714 0.135714 0.65 0.35 0.606972 29734.18 -0.368459 0.354839 0.516129 0.204301 0.086022 0.508961 0.491039 0.27957 0.150538 0.129032 6.336113 8.551971 NMV_2061 2193023 CDS +1 1982005 1982682 678 validated/Curated no tsaB tRNA threonylcarbamoyladenosine biosynthesis protein TsaB 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-27 15:18:17 no Belongs to MEROPS peptidase family M22 (clan MK). Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. 1 vladimir 0.187316 0.3186 0.29056 0.20354 0.609145 0.390855 0.190265 0.252212 0.402655 0.154867 0.654867 0.345133 0.221239 0.327434 0.190265 0.261062 0.517699 0.482301 0.150442 0.376106 0.278761 0.19469 0.654867 0.345133 0.64133 23863.23 0.021778 0.377778 0.56 0.195556 0.093333 0.617778 0.382222 0.217778 0.102222 0.115556 5.099983 9.408889 NMV_2062 2193024 CDS +3 1982679 1983119 441 validated/Curated no rimI [ribosomal protein S18]-alanine N-acetyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 2.3.1.266 2.3.1.128-RXN 2020-04-21 13:26:53 no This enzyme acetylates the N-terminal alanine of ribosomal protein S18. 2 vladimir 0.213152 0.3311 0.269841 0.185941 0.600907 0.399093 0.163265 0.258503 0.394558 0.183673 0.653061 0.346939 0.285714 0.312925 0.170068 0.231293 0.482993 0.517007 0.190476 0.421769 0.244898 0.142857 0.666667 0.333333 0.67542 16082.575 -0.20274 0.349315 0.527397 0.184932 0.10274 0.568493 0.431507 0.253425 0.123288 0.130137 5.361137 10.068493 NMV_2063 2193025 CDS +2 1983113 1983850 738 validated/Curated no putative DNA glycosylase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2020-04-23 19:11:37 no Belongs to a familiy of uracil-DNA glycosylases. Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosylic bond, initiating the base excision repair pathway. These aberrant uracil residues are genotoxic. 2 vladimir 0.208672 0.3564 0.262873 0.172087 0.619241 0.380759 0.203252 0.313008 0.357724 0.126016 0.670732 0.329268 0.235772 0.329268 0.174797 0.260163 0.504065 0.495935 0.186992 0.426829 0.256098 0.130081 0.682927 0.317073 0.643767 26217.55 -0.051837 0.330612 0.542857 0.216327 0.073469 0.62449 0.37551 0.204082 0.130612 0.073469 9.509056 9.546939 NMV_2064 2193026 CDS +3 1983912 1984553 642 validated/Curated no pyrE orotate phosphoribosyltransferase (OPRT; OPRTase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.2 : Pyrimidine biosynthesis ; 2.4.2.10 OROPRIBTRANS-RXN PWY-5686 2018-01-27 15:18:54 no Catalyses the following reaction: orotidine 5'-phosphate + diphosphate <=> orotate + 5-phospho-alpha-D-ribose 1-diphosphate. It is involved in the biosynthesis of pyrimidine nucleotides. 2 vladimir 0.238318 0.2928 0.260125 0.208723 0.55296 0.44704 0.228972 0.21028 0.38785 0.172897 0.598131 0.401869 0.28972 0.224299 0.163551 0.32243 0.38785 0.61215 0.196262 0.443925 0.228972 0.130841 0.672897 0.327103 0.709237 23260.86 0.033333 0.295775 0.483568 0.230047 0.107981 0.610329 0.389671 0.225352 0.112676 0.112676 5.989723 9.178404 NMV_2065 2193027 CDS +1 1984627 1985061 435 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 18:27:57 no 2 vladimir 0.227586 0.3563 0.216092 0.2 0.572414 0.427586 0.262069 0.275862 0.331034 0.131034 0.606897 0.393103 0.248276 0.303448 0.151724 0.296552 0.455172 0.544828 0.172414 0.489655 0.165517 0.172414 0.655172 0.344828 0.63603 15545.615 0.184028 0.319444 0.548611 0.243056 0.083333 0.618056 0.381944 0.194444 0.118056 0.076389 8.677528 9.118056 NMV_2066 2193028 CDS +3 1985058 1986368 1311 validated/Curated no argA amino-acid acetyltransferase (N-acetylglutamate synthase; AGS; NAGS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 2.3.1.1 N-ACETYLTRANSFER-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$GLUTORN-PWY 2018-01-27 15:19:28 no It is the first enzyme in arginine biosynthesis and catalyses the following reaction: acetyl-CoA + L-glutamate <=> CoA + N-acetyl-L-glutamate. 2 vladimir 0.193745 0.3646 0.268497 0.17315 0.633104 0.366895 0.19222 0.295195 0.375286 0.1373 0.670481 0.329519 0.254005 0.256293 0.212815 0.276888 0.469108 0.530892 0.135011 0.542334 0.217391 0.105263 0.759725 0.240275 0.633295 47222.825 -0.078899 0.350917 0.5 0.231651 0.100917 0.561927 0.438073 0.252294 0.142202 0.110092 6.659752 9.373853 NMV_2067 2193029 CDS +3 1986567 1988582 2016 validated/Curated no putative prolyl endopeptidase (post-proline cleaving enzyme; PE) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.4.21.26 3.4.21.26-RXN 2018-01-27 15:20:16 no Belongs to MEROPS peptidase family S9 (clan SC), subfamily S9A (prolyl oligopeptidase). Contains an unusual 7-stranded beta-propeller N-terminal domain, which protects the catalytic triad of prolyl oligopeptidase. 1 vladimir 0.214286 0.2748 0.300595 0.210317 0.575397 0.424603 0.18006 0.238095 0.376488 0.205357 0.614583 0.385417 0.313988 0.229167 0.200893 0.255952 0.43006 0.56994 0.14881 0.357143 0.324405 0.169643 0.681548 0.318452 0.70784 74623.93 -0.338152 0.298063 0.511177 0.205663 0.131148 0.563338 0.436662 0.251863 0.116244 0.135618 5.01432 9.606557 NMV_2068 2193030 CDS -1 1988696 1989652 957 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-27 15:20:29 no Belongs to the AraC family of transcriptional regulators. 2 vladimir 0.200627 0.3344 0.286311 0.178683 0.62069 0.37931 0.175549 0.294671 0.332288 0.197492 0.626959 0.373041 0.266458 0.22884 0.241379 0.263323 0.470219 0.529781 0.159875 0.479624 0.285266 0.075235 0.76489 0.23511 0.667197 35839.575 -0.316667 0.320755 0.455975 0.188679 0.125786 0.550314 0.449686 0.27673 0.166667 0.110063 9.068886 10.113208 NMV_2069 2193031 CDS +3 1989888 1990853 966 validated/Curated no putative ferric enterobactin uptake system-binding lipoprotein FetB2 3 : Putative function from multiple computational evidences rc : receptor 11 : Membrane 2018-01-27 15:20:43 no Homologous to FetB, a protein with sequence similarity to the family of periplasmic binding proteins necessary for transporting siderophores through the periplasmic space of gram-negative bacteria. 1 vladimir 0.219462 0.2857 0.321946 0.172878 0.60766 0.39234 0.226708 0.198758 0.431677 0.142857 0.630435 0.369565 0.285714 0.319876 0.15528 0.23913 0.475155 0.524845 0.145963 0.338509 0.378882 0.136646 0.717391 0.282609 0.616543 34250.49 -0.160748 0.352025 0.573209 0.205607 0.077882 0.582555 0.417445 0.23053 0.115265 0.115265 5.80558 9.604361 NMV_2070 2193032 CDS +2 1991480 1991803 324 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 18:26:02 no 1 vladimir 0.225309 0.2809 0.308642 0.185185 0.589506 0.410494 0.222222 0.212963 0.37963 0.185185 0.592593 0.407407 0.333333 0.185185 0.185185 0.296296 0.37037 0.62963 0.12037 0.444444 0.361111 0.074074 0.805556 0.194444 0.677635 12000.1 -0.274766 0.261682 0.485981 0.224299 0.130841 0.542056 0.457944 0.280374 0.140187 0.140187 5.429283 9.607477 NMV_2071 2193033 CDS +1 1991917 1994094 2178 validated/Curated no putative tonB-dependent ferric siderophore receptor protein 3 : Putative function from multiple computational evidences t : transporter 7 : Outer membrane protein 2018-01-27 15:21:06 no Is an outer-membrane active-transport protein, which interacts with the transperiplasmic protein TonB through a conserved sequence, the ''Ton-box''. Interaction with TonB couples the energy of the proton motive force of the inner-membrane to drive an outer-membrane transport cycle. 2 vladimir 0.230487 0.3747 0.25023 0.144628 0.624885 0.375115 0.254821 0.261708 0.334711 0.14876 0.596419 0.403581 0.301653 0.269972 0.22865 0.199725 0.498623 0.501377 0.134986 0.592287 0.187328 0.085399 0.779614 0.220386 0.754977 80373.48 -0.605655 0.346207 0.548966 0.158621 0.126897 0.521379 0.478621 0.235862 0.143448 0.092414 9.64193 9.94069 NMV_2072 2193034 CDS -3 1994511 1994834 324 validated/Curated no putative thiosulfate sulfurtransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 4.S.178 : thiosulfate ; 2.8.1.1 RXN0-6385$THIOSULFATE-SULFURTRANSFERASE-RXN PWY-5350 2018-01-29 22:18:21 no Belongs to the GlpE family. Catalyses the following reaction: thiosulfate + cyanide <=> sulfite + thiocyanate. 1 vladimir 0.209877 0.2099 0.333333 0.246914 0.54321 0.45679 0.222222 0.25 0.361111 0.166667 0.611111 0.388889 0.314815 0.185185 0.175926 0.324074 0.361111 0.638889 0.092593 0.194444 0.462963 0.25 0.657407 0.342593 0.636469 12049.35 0.007477 0.242991 0.485981 0.242991 0.11215 0.616822 0.383178 0.242991 0.093458 0.149533 4.456764 10.485981 NMV_2073 2193035 CDS -3 1994913 1995569 657 validated/Curated no pcm protein-L-isoaspartate O-methyltransferase (protein-beta-aspartate methyltransferase; PIMT; protein L-isoaspartyl methyltransferase; L-isoaspartyl protein carboxyl methyltransferase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.3.3 : Posttranslational modification ; 2.1.1.77 2.1.1.77-RXN 2018-01-27 19:06:59 no Catalyses the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. 1 vladimir 0.211568 0.1948 0.333333 0.260274 0.528158 0.471842 0.187215 0.187215 0.452055 0.173516 0.639269 0.360731 0.324201 0.191781 0.146119 0.3379 0.3379 0.6621 0.123288 0.205479 0.401826 0.269406 0.607306 0.392694 0.657255 23954.365 -0.044495 0.238532 0.518349 0.270642 0.077982 0.582569 0.417431 0.279817 0.114679 0.165138 4.57885 9.412844 NMV_2074 2193036 CDS -3 1995672 1996175 504 validated/Curated no putative free methionine-R-sulfoxide reductase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.8.4.14 1.8.4.14-RXN 2018-01-27 19:09:37 no 17535911 Might catalyse the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide. 1 vladimir 0.146825 0.2004 0.376984 0.275794 0.577381 0.422619 0.125 0.166667 0.446429 0.261905 0.613095 0.386905 0.261905 0.261905 0.178571 0.297619 0.440476 0.559524 0.053571 0.172619 0.505952 0.267857 0.678571 0.321429 0.559282 18164.85 0.148503 0.329341 0.556886 0.239521 0.125749 0.60479 0.39521 0.251497 0.107784 0.143713 4.71386 9.269461 NMV_2075 2193037 CDS +3 1996359 1997132 774 validated/Curated no tpiA triosephosphate isomerase (TIM; triose-phosphate isomerase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.1 : Glycolysis ; 5.3.1.1 TRIOSEPISOMERIZATION-RXN ANAGLYCOLYSIS-PWY$GLYCOLYSIS$GLYCOLYSIS-E-D 2018-01-27 15:24:06 no Is a glycolytic enzyme that catalyses the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production. 2 vladimir 0.253968 0.3280 0.238095 0.179894 0.566138 0.433862 0.269841 0.210317 0.376984 0.142857 0.587302 0.412698 0.309524 0.198413 0.174603 0.31746 0.373016 0.626984 0.18254 0.575397 0.162698 0.079365 0.738095 0.261905 0.684734 27529.41 0.073307 0.290837 0.505976 0.266932 0.095618 0.585657 0.414343 0.219124 0.10757 0.111554 5.383034 9.498008 NMV_2076 2193038 CDS +3 1997139 1997489 351 validated/Curated no secG protein translocase SecG subunit 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family ; 2018-01-30 16:22:00 no Part of the prokaryotic protein translocation apparatus essential for protein export. 2 vladimir 0.259259 0.2963 0.219373 0.225071 0.51567 0.48433 0.290598 0.188034 0.34188 0.179487 0.529915 0.470085 0.247863 0.307692 0.153846 0.290598 0.461538 0.538462 0.239316 0.393162 0.162393 0.205128 0.555556 0.444444 0.683432 12136.325 0.224138 0.405172 0.594828 0.198276 0.12069 0.586207 0.413793 0.12069 0.086207 0.034483 8.99337 8.551724 NMV_tRNA_31 2194846 tRNA +1 1997503 1997588 86 validated/Curated no Leu tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:58:42 no tRNA Leu anticodon GAG. vladimir NMNmiscRNA0152 54918938 misc_RNA +1 1997775 1997930 156 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 11:11:17 28334889 Function unknown. vladimir NMV_2077 2193039 CDS +3 1998498 1998866 369 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 12:58:32 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_2078) encodes the cognate antitoxin. 1 vladimir 0.327913 0.1897 0.284553 0.197832 0.474255 0.525745 0.308943 0.146341 0.382114 0.162602 0.528455 0.471545 0.373984 0.162602 0.195122 0.268293 0.357724 0.642276 0.300813 0.260163 0.276423 0.162602 0.536585 0.463415 0.498787 13905.345 -0.440984 0.262295 0.409836 0.213115 0.114754 0.52459 0.47541 0.336066 0.188525 0.147541 9.298424 9.163934 NMV_2078 2193040 CDS +2 1998863 1999174 312 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 12:58:28 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_2077) encodes the cognate toxin. 1 vladimir 0.304487 0.2404 0.282051 0.173077 0.522436 0.477564 0.375 0.115385 0.375 0.134615 0.490385 0.509615 0.346154 0.221154 0.163462 0.269231 0.384615 0.615385 0.192308 0.384615 0.307692 0.115385 0.692308 0.307692 0.576135 11148.6 -0.136893 0.330097 0.456311 0.213592 0.07767 0.572816 0.427184 0.291262 0.184466 0.106796 9.520699 8.699029 NMV_2080 2193042 fCDS -3 1999557 2000342 786 validated/Curated pseudo putative membrane-associated peptidase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-27 15:25:16 no Belongs to MEROPS peptidase family M48 (Ste24 endopeptidase family, clan M-). 1 vladimir 0.293893 0.2036 0.274809 0.227735 0.478371 0.521628 0.335878 0.160305 0.370229 0.133588 0.530534 0.469466 0.351145 0.236641 0.160305 0.251908 0.396947 0.603053 0.194656 0.21374 0.293893 0.29771 0.507634 0.492366 0.579867 28931.69 -0.471648 0.298851 0.524904 0.176245 0.099617 0.528736 0.471264 0.264368 0.149425 0.114943 7.979836 10.272031 NMV_2080.1 2610557 fCDS -1 2000384 2000416 33 validated/Curated pseudo putative membrane-associated peptidase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 2018-01-27 15:26:24 Belongs to MEROPS peptidase family M48 (Ste24 endopeptidase family, clan M-). vladimir NMV_2082 2193044 CDS -2 2000761 2001552 792 validated/Curated no drg Dam-replacing protein (DRP) 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 2018-01-27 15:27:11 no 11334887 In Dam-defective strains drg (dam-replacing gene) replaces dam. Drg encodes a restriction endonuclease (NmeBII) that cleaves 5'-GmeATC-3'. 2 vladimir 0.335859 0.2449 0.183081 0.236111 0.42803 0.57197 0.356061 0.227273 0.212121 0.204545 0.439394 0.560606 0.382576 0.174242 0.155303 0.287879 0.329545 0.670455 0.268939 0.333333 0.181818 0.215909 0.515152 0.484848 0.621526 30677.41 -0.562357 0.197719 0.414449 0.201521 0.117871 0.501901 0.498099 0.277567 0.174905 0.102662 9.435356 9.277567 NMV_2083 2193045 CDS -2 2001781 2004417 2637 validated/Curated no leuS leucine-tRNA ligase (leucyl-tRNA synthetase; LeuRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.4 LEUCINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:56:29 no Catalyses the attachment of leucine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.254276 0.3003 0.267959 0.177499 0.568225 0.431775 0.237172 0.196123 0.400228 0.166477 0.596351 0.403649 0.337514 0.22691 0.177879 0.257697 0.404789 0.595211 0.188141 0.477765 0.22577 0.108324 0.703535 0.296465 0.795016 97982.475 -0.34863 0.283105 0.51484 0.188356 0.119863 0.574201 0.425799 0.262557 0.125571 0.136986 5.254539 9.9121 NMV_2084 2193046 CDS +3 2004681 2005196 516 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 8 : Outer membrane-associated 2018-01-27 15:29:44 no Belongs to the SmpA/OmlA family of outer-membrane lipoproteins, possibly involved in maintaining the structural integrity of the cell envelope. 2 vladimir 0.273256 0.3159 0.228682 0.182171 0.544574 0.455426 0.273256 0.232558 0.337209 0.156977 0.569767 0.430233 0.343023 0.255814 0.151163 0.25 0.406977 0.593023 0.203488 0.459302 0.197674 0.139535 0.656977 0.343023 0.839159 19214.34 -0.480702 0.245614 0.54386 0.187135 0.122807 0.567251 0.432749 0.280702 0.157895 0.122807 8.679344 9.532164 NMV_2085 2193047 CDS +3 2005203 2005646 444 validated/Curated no hypothetical periplasmic protein 5 : Unknown function u : unknown 9 : Periplasmic 2008-04-15 18:22:02 no 2 vladimir 0.231982 0.2658 0.27027 0.231982 0.536036 0.463964 0.256757 0.216216 0.337838 0.189189 0.554054 0.445946 0.290541 0.202703 0.189189 0.317568 0.391892 0.608108 0.148649 0.378378 0.283784 0.189189 0.662162 0.337838 0.57172 16334.23 -0.007483 0.272109 0.510204 0.244898 0.115646 0.591837 0.408163 0.231293 0.129252 0.102041 7.847389 9.435374 NMV_2086 2193048 CDS +3 2005815 2007872 2058 validated/Curated no ppk polyphosphate kinase (polyphosphoric acid kinase; ATP-polyphosphate phosphotransferase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.8.1 : Phosphorous metabolism ; 2.7.4.1 POLYPHOSPHATE-KINASE-RXN 2018-01-27 15:30:16 no Catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. 2 vladimir 0.226919 0.3426 0.258989 0.171526 0.601555 0.398445 0.230321 0.285714 0.348397 0.135569 0.634111 0.365889 0.294461 0.221574 0.182216 0.301749 0.40379 0.59621 0.155977 0.520408 0.246356 0.077259 0.766764 0.233236 0.681906 77103.9 -0.229343 0.255474 0.474453 0.235036 0.106569 0.562044 0.437956 0.278832 0.159124 0.119708 8.753899 9.849635 NMV_2087 2193049 fCDS +3 2008089 2008343 255 validated/Curated pseudo IS1016 group transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:35:29 no 1 vladimir 0.247525 0.2310 0.267327 0.254125 0.49835 0.50165 0.227723 0.188119 0.386139 0.19802 0.574257 0.425743 0.306931 0.247525 0.158416 0.287129 0.405941 0.594059 0.207921 0.257426 0.257426 0.277228 0.514852 0.485149 0.640859 11261.365 -0.285 0.27 0.49 0.21 0.13 0.53 0.47 0.31 0.16 0.15 5.903419 9.31 NMV_2088 2193050 fCDS +2 2008370 2008690 321 validated/Curated pseudo IS1016 group transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-06-18 16:35:42 no 1 vladimir 0.308868 0.2110 0.244648 0.235474 0.455657 0.544343 0.394495 0.183486 0.256881 0.165138 0.440367 0.559633 0.357798 0.110092 0.238532 0.293578 0.348624 0.651376 0.174312 0.33945 0.238532 0.247706 0.577982 0.422018 0.517975 12682.185 -0.574074 0.212963 0.453704 0.25 0.12037 0.453704 0.546296 0.324074 0.240741 0.083333 10.437035 9.277778 NMV_2089 2193051 CDS -3 2008881 2009984 1104 validated/Curated no dnaN DNA polymerase III beta subunit 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN 2018-01-22 15:21:29 no DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. 1 vladimir 0.222826 0.2862 0.274457 0.216486 0.560688 0.439312 0.255435 0.263587 0.339674 0.141304 0.603261 0.396739 0.307065 0.195652 0.157609 0.339674 0.353261 0.646739 0.105978 0.399457 0.326087 0.168478 0.725543 0.274457 0.723978 40918.55 -0.049864 0.245232 0.47139 0.26703 0.079019 0.558583 0.441417 0.247956 0.114441 0.133515 5.021797 9.234332 NMV_2090 2193052 CDS -3 2010063 2011619 1557 validated/Curated no dnaA chromosomal replication initiator protein DnaA 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.1 : DNA replication ; 2018-01-27 15:30:45 no Plays an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC). 1 vladimir 0.244059 0.2550 0.285806 0.215157 0.540784 0.459216 0.252408 0.233141 0.368015 0.146435 0.601156 0.398844 0.331407 0.22736 0.159923 0.28131 0.387283 0.612717 0.148362 0.304432 0.32948 0.217726 0.633911 0.366089 0.641273 58109.265 -0.322008 0.266409 0.46139 0.216216 0.098456 0.540541 0.459459 0.291506 0.148649 0.142857 5.892952 9.590734 NMV_2091 2193053 CDS +3 2011911 2012045 135 validated/Curated no rpmH 50S ribosomal protein L34 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 15:31:01 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.251852 0.3556 0.244444 0.148148 0.6 0.4 0.244444 0.333333 0.288889 0.133333 0.622222 0.377778 0.222222 0.266667 0.311111 0.2 0.577778 0.422222 0.288889 0.466667 0.133333 0.111111 0.6 0.4 0.865827 5050.855 -0.956818 0.340909 0.454545 0.159091 0.068182 0.454545 0.545455 0.386364 0.386364 0 12.606804 10.295455 NMV_2092 2193054 CDS +2 2012048 2012413 366 validated/Curated no rnpA ribonuclease P protein component (RNaseP protein; RNase P protein; Protein C5) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 3.1.26.5 3.1.26.5-RXN$RXN0-6480 PWY0-1479 2020-04-22 13:48:07 no This is the protein component of RNase P, which is a site-specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5' ends. The RNA component is encoded by rnpB. 1 vladimir 0.262295 0.2896 0.265027 0.18306 0.554645 0.445355 0.262295 0.270492 0.286885 0.180328 0.557377 0.442623 0.303279 0.180328 0.262295 0.254098 0.442623 0.557377 0.221311 0.418033 0.245902 0.114754 0.663934 0.336066 0.595731 14269.91 -0.880165 0.22314 0.454545 0.173554 0.107438 0.471074 0.528926 0.338843 0.256198 0.082645 11.629799 10.347107 NMV_2093 2193055 CDS +3 2012478 2012699 222 validated/Curated no putative membrane protein insertion efficiency factor 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 15:31:57 no 21803992 Could be involved in insertion of integral membrane proteins into the membrane. 2 vladimir 0.216216 0.3468 0.238739 0.198198 0.585586 0.414414 0.202703 0.351351 0.22973 0.216216 0.581081 0.418919 0.243243 0.216216 0.256757 0.283784 0.472973 0.527027 0.202703 0.472973 0.22973 0.094595 0.702703 0.297297 0.561848 8202.5 0.009589 0.287671 0.452055 0.232877 0.150685 0.671233 0.328767 0.219178 0.191781 0.027397 9.9002 9.630137 NMV_2094 2193056 CDS +3 2012871 2014508 1638 validated/Curated no yidC oxaA membrane protein insertase YidC 2a : Function from experimental evidences in other organisms m : membrane component 5 : Inner membrane protein 2018-01-27 15:32:23 no Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. 2 vladimir 0.258242 0.3236 0.228327 0.189866 0.551893 0.448107 0.289377 0.227106 0.324176 0.159341 0.551282 0.448718 0.300366 0.249084 0.152015 0.298535 0.401099 0.598901 0.184982 0.494505 0.208791 0.111722 0.703297 0.296703 0.781098 60472.51 -0.032844 0.288073 0.500917 0.225688 0.117431 0.598165 0.401835 0.194495 0.106422 0.088073 8.413383 9.088073 NMV_2095 2193057 CDS -1 2014589 2015302 714 validated/Curated no putative ribosomal RNA small subunit methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 15:34:49 no Is homologous to the protein that catalyses the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. 1 vladimir 0.23416 0.2135 0.307163 0.245179 0.520661 0.479339 0.256198 0.247934 0.31405 0.181818 0.561983 0.438017 0.293388 0.252066 0.157025 0.297521 0.409091 0.590909 0.152893 0.140496 0.450413 0.256198 0.590909 0.409091 0.63946 26642.82 -0.210788 0.26971 0.489627 0.244813 0.074689 0.547718 0.452282 0.240664 0.13278 0.107884 6.730568 9.518672 NMV_2096 2193058 CDS -3 2015361 2015951 591 validated/Curated no 7-methyl-GTP pyrophosphatase 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 3.6.1.- 2020-04-21 16:43:12 no Catalyses the following reaction: 7-methyl-GTP + H2O <=> 7-methyl-GMP + diphosphate + H+. 1 vladimir 0.189509 0.2149 0.343486 0.252115 0.558376 0.441624 0.233503 0.208122 0.370558 0.187817 0.57868 0.42132 0.263959 0.192893 0.203046 0.340102 0.395939 0.604061 0.071066 0.243655 0.456853 0.228426 0.700508 0.299492 0.567341 21748.405 0.055102 0.270408 0.464286 0.265306 0.081633 0.591837 0.408163 0.255102 0.122449 0.132653 5.285515 9.673469 NMV_2097 2193059 CDS +3 2016099 2016602 504 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 18:18:25 no 1 vladimir 0.257937 0.2659 0.25 0.22619 0.515873 0.484127 0.238095 0.261905 0.327381 0.172619 0.589286 0.410714 0.339286 0.172619 0.160714 0.327381 0.333333 0.666667 0.196429 0.363095 0.261905 0.178571 0.625 0.375 0.603497 18928.8 -0.350898 0.215569 0.449102 0.239521 0.065868 0.502994 0.497006 0.311377 0.107784 0.203593 4.321434 9.341317 NMV_2098 2193060 CDS +3 2016636 2016815 180 validated/Curated no rpmF 50S ribosomal protein L32 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 15:35:54 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.283333 0.3611 0.222222 0.133333 0.583333 0.416667 0.266667 0.3 0.316667 0.116667 0.616667 0.383333 0.35 0.283333 0.183333 0.183333 0.466667 0.533333 0.233333 0.5 0.166667 0.1 0.666667 0.333333 0.855991 6473.09 -0.994915 0.322034 0.542373 0.135593 0.101695 0.440678 0.559322 0.338983 0.271186 0.067797 10.673836 9.59322 NMV_2099 2193061 CDS +3 2016990 2017517 528 validated/Curated no putative phosphoribosyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 15:36:31 no 1 vladimir 0.299242 0.2727 0.236742 0.191288 0.50947 0.49053 0.295455 0.176136 0.397727 0.130682 0.573864 0.426136 0.352273 0.164773 0.1875 0.295455 0.352273 0.647727 0.25 0.477273 0.125 0.147727 0.602273 0.397727 0.748607 19925.03 -0.212 0.234286 0.474286 0.245714 0.12 0.571429 0.428571 0.308571 0.137143 0.171429 4.851219 9.594286 NMV_2100 2193062 CDS +3 2017605 2018660 1056 validated/Curated no plsX phosphate acyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.1 : Phospholipid ; 2.3.1.274 2020-02-23 17:17:14 no Catalyses the reversible formation of acyl-phosphate from acyl-[acyl-ACP]. 2 vladimir 0.266098 0.3466 0.230114 0.157197 0.576705 0.423295 0.269886 0.238636 0.414773 0.076705 0.653409 0.346591 0.301136 0.252841 0.150568 0.295455 0.403409 0.596591 0.227273 0.548295 0.125 0.099432 0.673295 0.326705 0.684078 37073.97 0.014815 0.336182 0.54416 0.239316 0.062678 0.575499 0.424501 0.22792 0.119658 0.108262 6.211037 9.079772 NMV_2101 2193063 CDS +3 2018796 2018954 159 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:51:52 no 25569427 1 vladimir 0.308176 0.1698 0.226415 0.295597 0.396226 0.603774 0.301887 0.188679 0.264151 0.245283 0.45283 0.54717 0.358491 0.169811 0.132075 0.339623 0.301887 0.698113 0.264151 0.150943 0.283019 0.301887 0.433962 0.566038 0.485606 6170.115 -0.263462 0.230769 0.288462 0.211538 0.115385 0.519231 0.480769 0.365385 0.211538 0.153846 8.886452 9.192308 NMV_2102 2193064 CDS +3 2019066 2019491 426 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-15 18:17:04 no 3 vladimir 0.356808 0.1761 0.178404 0.288732 0.35446 0.64554 0.401408 0.126761 0.267606 0.204225 0.394366 0.605634 0.34507 0.190141 0.112676 0.352113 0.302817 0.697183 0.323944 0.211268 0.15493 0.309859 0.366197 0.633803 0.531858 16074.91 -0.111348 0.212766 0.41844 0.255319 0.120567 0.539007 0.460993 0.234043 0.106383 0.12766 5.048607 9.014184 NMV_2104 2193066 CDS +3 2019741 2020703 963 validated/Curated no fabH 3-oxoacyl-[acyl-carrier-protein] synthase III (beta-ketoacyl-ACP synthase III; KAS III) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 2.3.1.180 2.3.1.180-RXN$ACP-S-ACETYLTRANSFER-RXN$RXN-11474 PWY-4381$PWY-5966$PWY-6519 2018-02-01 16:34:29 no Catalyses the following reaction: acetyl-CoA + malonyl-[acyl-carrier-protein] <=> acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). 2 vladimir 0.245067 0.2876 0.26999 0.1973 0.557632 0.442368 0.28972 0.17134 0.392523 0.146417 0.563863 0.436137 0.274143 0.258567 0.190031 0.277259 0.448598 0.551402 0.17134 0.433022 0.227414 0.168224 0.660436 0.339564 0.721849 33833.165 0.061562 0.36875 0.571875 0.228125 0.08125 0.5875 0.4125 0.20625 0.10625 0.1 5.98246 8.921875 NMV_2105 2193067 CDS +1 2020750 2021157 408 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-15 18:16:30 no 1 vladimir 0.171569 0.2696 0.272059 0.286765 0.541667 0.458333 0.213235 0.242647 0.286765 0.257353 0.529412 0.470588 0.161765 0.235294 0.242647 0.360294 0.477941 0.522059 0.139706 0.330882 0.286765 0.242647 0.617647 0.382353 0.569637 14946.43 0.584444 0.340741 0.474074 0.281481 0.133333 0.681481 0.318519 0.177778 0.162963 0.014815 10.815895 9.074074 NMV_2106 2193068 CDS +1 2021251 2022177 927 validated/Curated no fabD malonyl CoA-acyl carrier protein transacylase (MCT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.4 : Fatty acid and phosphatidic acid ; 2.3.1.39 MALONYL-COA-ACP-TRANSACYL-RXN PWY-4381 2018-01-27 15:39:12 no Is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein. 2 vladimir 0.223301 0.3333 0.269687 0.173679 0.603021 0.396979 0.213592 0.187702 0.478964 0.119741 0.666667 0.333333 0.262136 0.304207 0.15534 0.278317 0.459547 0.540453 0.194175 0.508091 0.174757 0.122977 0.682848 0.317152 0.734863 31735.025 0.263312 0.383117 0.587662 0.220779 0.068182 0.646104 0.353896 0.191558 0.094156 0.097403 5.443596 9.438312 NMV_2107 2193069 CDS +3 2022315 2024180 1866 validated/Curated no msbA lipid A export ATP-binding/permease protein MsbA 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 1.6.3 : Lipopolysaccharide ; 3.6.3.39-RXN 2018-01-31 20:54:04 no Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. 2 vladimir 0.237406 0.3462 0.224009 0.19239 0.570204 0.429796 0.297428 0.249196 0.313505 0.139871 0.562701 0.437299 0.257235 0.233119 0.162379 0.347267 0.395498 0.604502 0.157556 0.55627 0.196141 0.090032 0.752412 0.247588 0.677206 68836.22 0.184219 0.293076 0.487923 0.268921 0.091787 0.573269 0.426731 0.201288 0.109501 0.091787 8.248039 9.10628 NMV_2108 2193070 CDS +3 2024280 2025845 1566 validated/Curated no guaA GMP synthase [glutamine-hydrolyzing] (glutamine amidotransferase; GMP synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 6.3.5.2 GMP-SYN-GLUT-RXN$GMP-SYN-NH3-RXN PWY-6125 2018-01-27 15:47:50 no Catalyses the following reaction in the de novo purine biosynthetic pathway: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O <=> AMP + diphosphate + GMP + L-glutamate. 2 vladimir 0.250958 0.2944 0.254789 0.199872 0.54917 0.45083 0.245211 0.210728 0.385057 0.159004 0.595785 0.404215 0.321839 0.195402 0.172414 0.310345 0.367816 0.632184 0.185824 0.477012 0.206897 0.130268 0.683908 0.316092 0.801491 57666.76 -0.144146 0.264875 0.493282 0.239923 0.109405 0.575816 0.424184 0.264875 0.132438 0.132438 5.522957 9.481766 NMV_2109 2193071 CDS +1 2025907 2026653 747 validated/Curated no fabG 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.4 : Fatty acid and phosphatidic acid ; 1.1.1.100 3-OXOACYL-ACP-REDUCT-RXN$RXN-10655$RXN-10659$RXN-11476$RXN-11480$RXN-9514$RXN-9518$RXN-9524$RXN-9528$RXN-9532$RXN-9536$RXN-9540$RXN-9556$RXN-9633$RXN0-2142 FASYN-ELONG-PWY$PWY-5971$PWY-5973$PWY-6282$PWY-6519$PWY0-862 2018-01-30 12:46:04 no Catalyses the following reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH. 2 vladimir 0.247657 0.3052 0.273092 0.174029 0.578313 0.421687 0.309237 0.15261 0.417671 0.120482 0.570281 0.429719 0.24498 0.26506 0.204819 0.285141 0.46988 0.53012 0.188755 0.497992 0.196787 0.116466 0.694779 0.305221 0.747998 26066.685 0.027016 0.387097 0.564516 0.21371 0.048387 0.572581 0.427419 0.209677 0.104839 0.104839 5.991859 9.520161 NMV_2110 2193072 CDS -3 2026917 2027150 234 validated/Curated partial truncated ISNme1 transposase (C-terminal 23% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-27 15:48:33 no Belongs to the IS5 family. 2 vladimir 0.242424 0.2559 0.299663 0.20202 0.555556 0.444444 0.292929 0.252525 0.272727 0.181818 0.525253 0.474747 0.272727 0.232323 0.252525 0.242424 0.484848 0.515152 0.161616 0.282828 0.373737 0.181818 0.656566 0.343434 0.535715 10960.515 -0.277551 0.346939 0.459184 0.183673 0.112245 0.571429 0.428571 0.244898 0.22449 0.020408 11.063164 9.714286 NMV_2111 2193073 CDS -3 2027217 2027633 417 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 18:14:33 no 1 vladimir 0.223022 0.2134 0.270983 0.292566 0.484412 0.515588 0.179856 0.266187 0.294964 0.258993 0.561151 0.438849 0.352518 0.165468 0.223022 0.258993 0.388489 0.611511 0.136691 0.208633 0.294964 0.359712 0.503597 0.496403 0.608761 16679.185 -0.61087 0.202899 0.405797 0.188406 0.231884 0.536232 0.463768 0.311594 0.188406 0.123188 7.297096 10.065217 NMV_2112 2193074 fCDS +2 2028356 2028448 93 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 15:48:52 no Belongs to the IS5 family. 2 vladimir 0.27957 0.2796 0.193548 0.247312 0.473118 0.526882 0.322581 0.258065 0.225806 0.193548 0.483871 0.516129 0.322581 0.193548 0.096774 0.387097 0.290323 0.709677 0.193548 0.387097 0.258065 0.16129 0.645161 0.354839 0.713612 3506.995 0.096667 0.2 0.366667 0.233333 0.133333 0.533333 0.466667 0.233333 0.133333 0.1 6.749474 8.2 NMV_2113 2193075 fCDS +2 2028449 2029363 915 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 15:49:05 no Belongs to the IS5 family. 2 vladimir 0.284349 0.2891 0.230585 0.195938 0.519713 0.480287 0.286738 0.258065 0.286738 0.168459 0.544803 0.455197 0.362007 0.204301 0.18638 0.247312 0.390681 0.609319 0.204301 0.405018 0.218638 0.172043 0.623656 0.376344 0.655604 31480.815 -0.452158 0.294964 0.442446 0.21223 0.111511 0.492806 0.507194 0.28777 0.172662 0.115108 8.846825 9.122302 NMV_2114 2193076 CDS +2 2029733 2030116 384 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 6 : Inner membrane-associated 2018-01-27 15:49:20 no Contains a SEC-C motif found in the C-terminus of the SecA protein, which is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain. 2 vladimir 0.263021 0.2943 0.210938 0.231771 0.505208 0.494792 0.21875 0.28125 0.296875 0.203125 0.578125 0.421875 0.3125 0.203125 0.179688 0.304688 0.382812 0.617188 0.257812 0.398438 0.15625 0.1875 0.554688 0.445312 0.603493 14302.13 0.027559 0.275591 0.448819 0.23622 0.15748 0.614173 0.385827 0.228346 0.149606 0.07874 8.647835 9.275591 NMNmiscRNA0171 54919404 misc_RNA -1 2030113 2030264 152 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-29 13:10:36 28334889 Function unknown. vladimir NMV_2115 2193077 CDS -1 2030336 2031130 795 validated/Curated no putative inositol monophosphatase-like protein 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.1.3.- 2018-06-21 13:31:45 no 1 vladimir 0.201258 0.2138 0.338365 0.246541 0.552201 0.447799 0.215094 0.211321 0.369811 0.203774 0.581132 0.418868 0.275472 0.2 0.237736 0.286792 0.437736 0.562264 0.113208 0.230189 0.407547 0.249057 0.637736 0.362264 0.551431 29367.355 -0.151515 0.306818 0.484848 0.219697 0.125 0.583333 0.416667 0.242424 0.128788 0.113636 6.354591 9.587121 NMV_2116 2193078 CDS +3 2031339 2032064 726 validated/Curated no rsmE ribosomal RNA small subunit methyltransferase E 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.193 RXN-11598 2018-01-27 15:50:04 no 17872509 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. 2 vladimir 0.258953 0.3581 0.227273 0.155647 0.585399 0.414601 0.264463 0.285124 0.347107 0.103306 0.632231 0.367769 0.276859 0.243802 0.18595 0.293388 0.429752 0.570248 0.235537 0.545455 0.14876 0.070248 0.694215 0.305785 0.648991 26692.65 -0.207884 0.286307 0.477178 0.240664 0.06639 0.53527 0.46473 0.261411 0.136929 0.124481 6.273628 9.630705 NMV_2117 2193079 CDS -1 2034248 2035090 843 validated/Curated no lgtE lacto-N-neotetraose biosynthesis glycosyl transferase LgtE 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.-.-.- 2018-01-22 18:38:38 no 12618369, 7964493, 8817494 Adds the first galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS). 1 vladimir 0.264531 0.1886 0.290629 0.256228 0.479241 0.520759 0.252669 0.174377 0.355872 0.217082 0.530249 0.469751 0.33452 0.16726 0.177936 0.320285 0.345196 0.654804 0.206406 0.224199 0.338078 0.231317 0.562278 0.437722 0.571412 32791.705 -0.345714 0.210714 0.389286 0.203571 0.146429 0.542857 0.457143 0.335714 0.182143 0.153571 7.260674 9.725 NMV_2118 2193080 CDS -3 2035239 2036066 828 validated/Curated no lgtB lacto-N-neotetraose biosynthesis glycosyl transferase LgtB 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.-.-.- 2018-01-22 18:39:25 no 7964493, 8817494 Adds the second galactose to the lacto-N-tetraose chain in lipooligosaccharide (LOS). 1 vladimir 0.241546 0.2778 0.262077 0.218599 0.539855 0.460145 0.224638 0.25 0.326087 0.199275 0.576087 0.423913 0.304348 0.206522 0.177536 0.311594 0.384058 0.615942 0.195652 0.376812 0.282609 0.144928 0.65942 0.34058 0.641913 31576.26 -0.220364 0.247273 0.410909 0.2 0.145455 0.56 0.44 0.287273 0.16 0.127273 6.875404 9.436364 NMV_2119 2193081 CDS -1 2036108 2037154 1047 validated/Curated no lgtA lacto-N-neotetraose biosynthesis glycosyl tranferase LgtA 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.-.-.- 2017-09-30 20:15:03 no 10521543, 12618369, 7964493 1 vladimir 0.268386 0.2502 0.260745 0.22063 0.510984 0.489016 0.266476 0.2149 0.318052 0.200573 0.532951 0.467049 0.346705 0.186246 0.197708 0.269341 0.383954 0.616046 0.191977 0.34957 0.266476 0.191977 0.616046 0.383954 0.627751 40580.825 -0.547701 0.232759 0.416667 0.201149 0.135057 0.517241 0.482759 0.316092 0.181034 0.135057 9.183708 9.784483 NMV_2120 2193082 CDS -3 2037171 2039234 2064 validated/Curated no glyS glycine-tRNA ligase beta chain (glycyl-tRNA synthetase beta chain; GlyRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.14 GLYCINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:57:11 no Is composed of alpha and beta chains. Catalyses the attachment of glycine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.252422 0.2951 0.266957 0.185562 0.562016 0.437984 0.222384 0.231105 0.418605 0.127907 0.649709 0.350291 0.329942 0.247093 0.12936 0.293605 0.376453 0.623547 0.204942 0.406977 0.252907 0.135174 0.659884 0.340116 0.790114 74725.72 -0.098108 0.286754 0.491994 0.238719 0.07278 0.574964 0.425036 0.253275 0.123726 0.129549 5.448616 9.372635 NMV_2121 2193083 CDS -1 2039255 2039665 411 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 18:11:57 no 1 vladimir 0.245742 0.2336 0.284672 0.23601 0.518248 0.481752 0.211679 0.20438 0.379562 0.20438 0.583942 0.416058 0.350365 0.175182 0.226277 0.248175 0.40146 0.59854 0.175182 0.321168 0.248175 0.255474 0.569343 0.430657 0.726626 15269.605 -0.491912 0.301471 0.455882 0.161765 0.147059 0.558824 0.441176 0.294118 0.147059 0.147059 5.539513 9.720588 NMV_2122 2193084 CDS -3 2039742 2040647 906 validated/Curated no glyQ glycine-tRNA ligase alpha chain (glycyl-tRNA synthetase alpha chain; GlyRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.14 GLYCINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:57:51 no Is composed of alpha and beta chains. Catalyses the attachment of glycine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.247241 0.3278 0.237307 0.187638 0.565121 0.434879 0.208609 0.254967 0.360927 0.175497 0.615894 0.384106 0.34106 0.211921 0.178808 0.268212 0.390728 0.609272 0.192053 0.516556 0.172185 0.119205 0.688742 0.311258 0.728001 34224.4 -0.300997 0.265781 0.481728 0.209302 0.142857 0.578073 0.421927 0.232558 0.106312 0.126246 4.98217 9.983389 NMV_2123 2193085 CDS -1 2041052 2041474 423 validated/Curated no atpC ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:28:55 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.250591 0.2009 0.312057 0.236407 0.513002 0.486998 0.234043 0.170213 0.468085 0.12766 0.638298 0.361702 0.319149 0.255319 0.134752 0.29078 0.390071 0.609929 0.198582 0.177305 0.333333 0.29078 0.510638 0.489362 0.658757 14974.645 -0.028571 0.307143 0.521429 0.257143 0.05 0.564286 0.435714 0.285714 0.142857 0.142857 5.644615 9.185714 NMV_2124 2193086 CDS -3 2041485 2042882 1398 validated/Curated no atpD ATP synthase beta chain 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:29:16 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 2 vladimir 0.248212 0.2539 0.26824 0.229614 0.522175 0.477825 0.251073 0.178112 0.401288 0.169528 0.579399 0.420601 0.296137 0.23176 0.165236 0.306867 0.396996 0.603004 0.197425 0.351931 0.238197 0.212446 0.590129 0.409871 0.814066 50419.5 -0.119785 0.301075 0.537634 0.24086 0.077419 0.56129 0.43871 0.251613 0.116129 0.135484 5.008659 9.447312 NMV_2125 2193087 CDS -2 2042920 2043795 876 validated/Curated no atpG ATP synthase gamma chain 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:29:29 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.280822 0.2021 0.265982 0.251142 0.468037 0.531963 0.297945 0.19863 0.342466 0.160959 0.541096 0.458904 0.311644 0.215753 0.164384 0.308219 0.380137 0.619863 0.232877 0.191781 0.291096 0.284247 0.482877 0.517123 0.653804 32492.44 -0.15945 0.278351 0.460481 0.24055 0.072165 0.542955 0.457045 0.247423 0.140893 0.106529 9.008324 9.90378 NMV_2126 2193088 CDS -2 2043820 2045367 1548 validated/Curated no atpA ATP synthase alpha chain 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:29:43 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.241602 0.2422 0.264858 0.251292 0.507106 0.492894 0.244186 0.178295 0.408915 0.168605 0.587209 0.412791 0.284884 0.263566 0.156977 0.294574 0.420543 0.579457 0.195736 0.284884 0.228682 0.290698 0.513566 0.486434 0.769231 55341.98 -0.036893 0.330097 0.530097 0.242718 0.069903 0.561165 0.438835 0.240777 0.118447 0.12233 5.505974 9.417476 NMV_2127 2193089 CDS -1 2045378 2045911 534 validated/Curated no atpH ATP synthase delta chain 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:30:05 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.282772 0.1910 0.264045 0.262172 0.455056 0.544944 0.269663 0.146067 0.370787 0.213483 0.516854 0.483146 0.353933 0.207865 0.106742 0.331461 0.314607 0.685393 0.224719 0.219101 0.314607 0.241573 0.533708 0.466292 0.64767 19496.75 0.024294 0.259887 0.451977 0.288136 0.073446 0.559322 0.440678 0.248588 0.112994 0.135593 5.017738 8.485876 NMV_2128 2193090 CDS -3 2045916 2046386 471 validated/Curated no atpF ATP synthase b chain 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:30:34 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.26327 0.2357 0.282378 0.218684 0.518047 0.481953 0.203822 0.165605 0.477707 0.152866 0.643312 0.356688 0.33758 0.267516 0.11465 0.280255 0.382166 0.617834 0.248408 0.273885 0.254777 0.22293 0.528662 0.471338 0.738364 17105.935 -0.132051 0.301282 0.461538 0.224359 0.064103 0.538462 0.461538 0.314103 0.153846 0.160256 5.645363 9.217949 NMV_2129 2193091 CDS -2 2046457 2046693 237 validated/Curated no atpE ATP synthase c chain (lipid-binding protein; dicyclohexylcarbodiimide-binding protein) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:30:54 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.164557 0.2321 0.265823 0.337553 0.49789 0.50211 0.202532 0.151899 0.405063 0.240506 0.556962 0.443038 0.126582 0.291139 0.151899 0.43038 0.443038 0.556962 0.164557 0.253165 0.240506 0.341772 0.493671 0.506329 0.872117 7815.135 1.425641 0.397436 0.512821 0.346154 0.076923 0.820513 0.179487 0.076923 0.038462 0.038462 6.215736 7.833333 NMV_2130 2193092 CDS -3 2046750 2047616 867 validated/Curated no atpB ATP synthase a chain (ATPase protein 6) 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:31:09 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.196078 0.2272 0.27451 0.302191 0.50173 0.49827 0.252595 0.16955 0.349481 0.228374 0.519031 0.480969 0.217993 0.211073 0.152249 0.418685 0.363322 0.636678 0.117647 0.301038 0.321799 0.259516 0.622837 0.377163 0.715712 31416.905 0.80625 0.295139 0.475694 0.305556 0.15625 0.697917 0.302083 0.159722 0.09375 0.065972 6.415688 8.385417 NMV_2131 2193093 CDS -2 2047606 2047959 354 validated/Curated no atpI ATP synthase membrane-bound accesory subunit 2a : Function from experimental evidences in other organisms e : enzyme 11 : Membrane 1.3.8 : ATP proton motive force interconversion ; 7.1.2.2 ATPSYN-RXN PWY-6126 2020-04-21 13:31:31 no Produces ATP from ADP in the presence of a proton gradient across the membrane. 1 vladimir 0.172316 0.2119 0.265537 0.350282 0.477401 0.522599 0.177966 0.186441 0.330508 0.305085 0.516949 0.483051 0.127119 0.186441 0.169492 0.516949 0.355932 0.644068 0.211864 0.262712 0.29661 0.228814 0.559322 0.440678 0.507304 12789.11 1.357265 0.273504 0.452991 0.384615 0.153846 0.769231 0.230769 0.102564 0.08547 0.017094 10.292412 7.709402 NMV_2134 2193096 CDS -1 2048327 2048665 339 validated/Curated no hypothetical lipoprotein 5 : Unknown function u : unknown 11 : Membrane 2008-04-15 16:59:45 no 1 vladimir 0.268437 0.2507 0.250737 0.230089 0.501475 0.498525 0.353982 0.123894 0.353982 0.168142 0.477876 0.522124 0.221239 0.247788 0.256637 0.274336 0.504425 0.495575 0.230089 0.380531 0.141593 0.247788 0.522124 0.477876 0.674238 11514.755 0.261607 0.446429 0.642857 0.241071 0.044643 0.5625 0.4375 0.151786 0.116071 0.035714 9.78933 9.160714 NMV_2135 2193097 CDS -2 2048800 2049660 861 validated/Curated no putative chromosome partitioning protein ParB 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 15:57:54 no Involved in chromosome partition. Localise to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. 1 vladimir 0.264808 0.3031 0.267131 0.164925 0.570267 0.429733 0.25784 0.278746 0.369338 0.094077 0.648084 0.351916 0.324042 0.209059 0.191638 0.275261 0.400697 0.599303 0.212544 0.421603 0.240418 0.125436 0.662021 0.337979 0.65067 31612.995 -0.376573 0.272727 0.454545 0.251748 0.052448 0.517483 0.482517 0.297203 0.164336 0.132867 9.056282 9.423077 NMV_2136 2193098 CDS +2 2049818 2050387 570 validated/Curated no ubiX flavin prenyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 2.5.1.129 3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN PWY-6708 2018-01-27 16:00:32 no Flavin prenyltransferase that catalyses the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN. Acts in concert with UbiD to perform the decarboxylation of 4-hydroxy-3-octaprenyl-benzoate, a step in the biosynthesis of coenzyme Q. 1 vladimir 0.201754 0.2386 0.342105 0.217544 0.580702 0.419298 0.231579 0.205263 0.415789 0.147368 0.621053 0.378947 0.242105 0.257895 0.184211 0.315789 0.442105 0.557895 0.131579 0.252632 0.426316 0.189474 0.678947 0.321053 0.542763 20391.75 0.137037 0.328042 0.550265 0.238095 0.089947 0.608466 0.391534 0.243386 0.132275 0.111111 6.319878 9.804233 NMV_2137 2193099 CDS -3 2050449 2051312 864 validated/Curated no putative D-methionine-binding lipoprotein MetQ 3 : Putative function from multiple computational evidences rc : receptor 8 : Outer membrane-associated 2018-01-27 16:01:12 no Part of the binding-protein-dependent transport system MetNIQ for D-methionine and the toxic methionine analog alpha-methyl-methionine. Belongs to the NlpA lipoprotein family. 2 vladimir 0.27662 0.3125 0.241898 0.168981 0.554398 0.445602 0.267361 0.170139 0.409722 0.152778 0.579861 0.420139 0.361111 0.260417 0.118056 0.260417 0.378472 0.621528 0.201389 0.506944 0.197917 0.09375 0.704861 0.295139 0.763115 31278.15 -0.251568 0.30662 0.536585 0.198606 0.10453 0.550523 0.449477 0.268293 0.125436 0.142857 5.113335 8.783972 NMV_2138 2193100 CDS -1 2051471 2052157 687 validated/Curated no putative D-methionine transport system permease protein MetI 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:01:29 no Part of the binding-protein-dependent transport system MetNIQ for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane. 2 vladimir 0.187773 0.3159 0.26492 0.231441 0.580786 0.419214 0.257642 0.200873 0.375546 0.165939 0.576419 0.423581 0.170306 0.222707 0.174672 0.432314 0.39738 0.60262 0.135371 0.524017 0.244541 0.09607 0.768559 0.231441 0.684876 24233.015 0.939912 0.315789 0.517544 0.346491 0.083333 0.710526 0.289474 0.127193 0.078947 0.048246 9.668419 8.894737 NMV_2139 2193101 CDS -3 2052159 2052896 738 validated/Curated no putative D-methionine transport system ATP-binding protein MetN 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2018-01-27 16:01:48 no Part of the binding-protein-dependent transport system MetNIQ for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for energy coupling to the transport system. 2 vladimir 0.241192 0.3157 0.261518 0.181572 0.577236 0.422764 0.256098 0.239837 0.373984 0.130081 0.613821 0.386179 0.284553 0.211382 0.199187 0.304878 0.410569 0.589431 0.182927 0.495935 0.211382 0.109756 0.707317 0.292683 0.645638 27009.04 -0.12898 0.285714 0.489796 0.265306 0.057143 0.538776 0.461224 0.273469 0.146939 0.126531 7.854973 9.689796 NMV_misc_RNA_2 2194961 misc_RNA -1 2052951 2053019 69 validated/Curated no SAM II riboswitch 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 18:52:56 28334889 The SAM-II riboswitch is a RNA element that binds S-adenosyl methionine (SAM). Like the other SAM riboswitch, it probably functions to turn off expression of these genes in response to elevated SAM levels. vladimir NMV_2140 2193102 CDS +1 2053426 2055273 1848 validated/Curated no slt soluble lytic murein transglycosylase 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.7.34 : Peptidoglycan (murein) turnover, recycling ; 3.2.1.- RXN0-5190 2018-02-01 18:07:06 no Murein-degrading enzyme. Catalyses the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division. 2 vladimir 0.23539 0.3079 0.287338 0.169372 0.595238 0.404762 0.232143 0.24026 0.38474 0.142857 0.625 0.375 0.297078 0.280844 0.206169 0.215909 0.487013 0.512987 0.176948 0.402597 0.271104 0.149351 0.673701 0.326299 0.681735 67612.74 -0.437724 0.346341 0.531707 0.169106 0.094309 0.549593 0.450407 0.247154 0.139837 0.107317 9.338905 10.006504 NMV_2141 2193103 CDS +1 2055562 2055774 213 validated/Curated no rpsU 30S ribosomal protein S21 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 16:02:04 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.333333 0.3239 0.220657 0.122066 0.544601 0.455399 0.295775 0.352113 0.28169 0.070423 0.633803 0.366197 0.352113 0.239437 0.183099 0.225352 0.422535 0.577465 0.352113 0.380282 0.197183 0.070423 0.577465 0.422535 0.870014 8384.675 -1.111429 0.2 0.342857 0.157143 0.057143 0.442857 0.557143 0.414286 0.3 0.114286 11.020866 10.614286 NMV_2142 2193104 CDS +3 2055906 2056352 447 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-27 16:02:23 no Contains a domain found at the C terminus of GatB, which transamidates Glu-tRNA to Gln-tRNA. 2 vladimir 0.290828 0.3043 0.257271 0.147651 0.561521 0.438479 0.328859 0.181208 0.436242 0.053691 0.61745 0.38255 0.322148 0.248322 0.14094 0.288591 0.389262 0.610738 0.221477 0.483221 0.194631 0.100671 0.677852 0.322148 0.818129 16092.075 -0.192568 0.317568 0.493243 0.222973 0.027027 0.527027 0.472973 0.317568 0.168919 0.148649 8.819267 9.608108 NMV_2143 2193105 CDS -3 2056551 2057006 456 validated/Curated no putative SspB-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-31 19:50:50 no Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. 2 vladimir 0.254453 0.3359 0.229008 0.180662 0.564885 0.435114 0.29771 0.244275 0.29771 0.160305 0.541985 0.458015 0.29771 0.251908 0.19084 0.259542 0.442748 0.557252 0.167939 0.51145 0.198473 0.122137 0.709924 0.290076 0.61659 14641.085 -0.343846 0.292308 0.515385 0.2 0.115385 0.530769 0.469231 0.238462 0.123077 0.115385 5.765205 9.684615 NMV_2144 2193106 CDS -2 2057014 2057619 606 validated/Curated no sspA stringent starvation protein A 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2020-04-22 13:07:00 no Forms an equimolar complex with the RNA polymerase holoenzyme but not with the core enzyme. It is synthesized predominantly when cells are exposed to amino acid starvation. 2 vladimir 0.255776 0.3036 0.232673 0.207921 0.536304 0.463696 0.262376 0.262376 0.326733 0.148515 0.589109 0.410891 0.346535 0.188119 0.143564 0.321782 0.331683 0.668317 0.158416 0.460396 0.227723 0.153465 0.688119 0.311881 0.7174 23164.05 -0.265672 0.199005 0.427861 0.228856 0.119403 0.572139 0.427861 0.293532 0.154229 0.139303 6.256432 9.930348 NMV_2145 2193107 CDS -3 2057874 2059550 1677 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-04-15 16:56:16 no 2 vladimir 0.155635 0.3059 0.292785 0.245677 0.598688 0.401312 0.184258 0.271914 0.332737 0.211091 0.604651 0.395349 0.173524 0.288014 0.194991 0.34347 0.483005 0.516995 0.109123 0.357782 0.350626 0.182469 0.708408 0.291592 0.641628 61889.505 0.47724 0.310036 0.514337 0.250896 0.166667 0.709677 0.290323 0.150538 0.102151 0.048387 9.759102 9.143369 NMV_2146 2193108 CDS -2 2059711 2060325 615 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2020-04-20 19:30:49 no Is a member of the Cadmium Resistance (CadD) family of transport proteins. 3 vladimir 0.269537 0.1483 0.196172 0.385965 0.344498 0.655502 0.315789 0.129187 0.291866 0.263158 0.421053 0.578947 0.220096 0.148325 0.148325 0.483254 0.296651 0.703349 0.272727 0.167464 0.148325 0.411483 0.315789 0.684211 0.44923 23054.865 1.025 0.245192 0.4375 0.389423 0.115385 0.697115 0.302885 0.139423 0.072115 0.067308 7.898766 7.9375 NMV_2148 2193110 CDS -3 2060640 2060855 216 validated/Curated no rpmE 50S ribosomal protein L31 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 16:04:01 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.328704 0.2917 0.180556 0.199074 0.472222 0.527778 0.375 0.152778 0.25 0.222222 0.402778 0.597222 0.402778 0.180556 0.166667 0.25 0.347222 0.652778 0.208333 0.541667 0.125 0.125 0.666667 0.333333 0.909646 8117.92 -0.61831 0.28169 0.521127 0.140845 0.15493 0.464789 0.535211 0.267606 0.183099 0.084507 9.028297 9.985915 NMV_2149 2193111 fCDS +3 2061093 2061395 303 validated/Curated pseudo putative acetyltransferase (pseudogene part 1) 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2.3.1.- 2015-11-21 18:51:48 no 1 vladimir 0.1875 0.2214 0.335938 0.255208 0.557292 0.442708 0.226562 0.210938 0.328125 0.234375 0.539062 0.460938 0.179688 0.1875 0.320312 0.3125 0.507812 0.492188 0.15625 0.265625 0.359375 0.21875 0.625 0.375 0.518597 14025.82 -0.151181 0.322835 0.511811 0.212598 0.110236 0.598425 0.401575 0.251969 0.19685 0.055118 11.518181 10.133858 NMV_2150 2193112 fCDS +2 2061392 2061607 216 validated/Curated pseudo putative acetyltransferase (pseudogene part 2) 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2.3.1.- 2008-06-18 16:37:35 no 1 vladimir 0.202381 0.2202 0.380952 0.196429 0.60119 0.39881 0.196429 0.142857 0.535714 0.125 0.678571 0.321429 0.214286 0.267857 0.214286 0.303571 0.482143 0.517857 0.196429 0.25 0.392857 0.160714 0.642857 0.357143 0.63257 5565.15 0.263636 0.327273 0.709091 0.290909 0.054545 0.690909 0.309091 0.2 0.109091 0.090909 6.76368 9.636364 NMV_2151 2193113 CDS -2 2061688 2062176 489 validated/Curated no putative ResA-like thiol-disulfide oxidoreductase 3 : Putative function from multiple computational evidences e : enzyme 9 : Periplasmic 2018-01-27 16:04:29 no Is probably required in disulfide reduction during c-type cytochrome synthesis. 1 vladimir 0.276074 0.3108 0.204499 0.208589 0.515337 0.484663 0.300613 0.214724 0.343558 0.141104 0.558282 0.441718 0.319018 0.245399 0.110429 0.325153 0.355828 0.644172 0.208589 0.472393 0.159509 0.159509 0.631902 0.368098 0.676278 17621.865 0.166667 0.277778 0.530864 0.265432 0.098765 0.617284 0.382716 0.197531 0.104938 0.092593 7.882744 8.493827 NMV_2152 2193114 CDS -3 2062173 2062556 384 validated/Curated no fadM long-chain acyl-CoA thioesterase FadM 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 3.1.2.- 2018-01-23 10:57:14 no 18576672 Long-chain acyl-CoA thioesterase with a preference for 3,5-tetradecadienoyl-CoA. Could be involved in beta-oxidation of fatty acids. 2 vladimir 0.221354 0.3542 0.244792 0.179688 0.598958 0.401042 0.226562 0.289062 0.34375 0.140625 0.632812 0.367188 0.25 0.257812 0.1875 0.304688 0.445312 0.554688 0.1875 0.515625 0.203125 0.09375 0.71875 0.28125 0.679036 14277.99 -0.022047 0.299213 0.464567 0.251969 0.110236 0.566929 0.433071 0.259843 0.149606 0.110236 8.218239 9.968504 NMV_2153 2193115 CDS -1 2062556 2062918 363 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2020-04-20 21:54:14 no 2 vladimir 0.248447 0.3168 0.225673 0.20911 0.542443 0.457557 0.217391 0.242236 0.347826 0.192547 0.590062 0.409938 0.329193 0.229814 0.167702 0.273292 0.397516 0.602484 0.198758 0.478261 0.161491 0.161491 0.639752 0.360248 0.691544 18506.955 -0.365 0.23125 0.4875 0.20625 0.125 0.53125 0.46875 0.28125 0.075 0.20625 4.026527 9.90625 NMV_2154 2193116 CDS -3 2063043 2063870 828 validated/Curated no putative phospholipid-binding lipoprotein MlaA 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 2018-01-27 16:06:31 no 19383799 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. 2 vladimir 0.231884 0.3213 0.257246 0.189614 0.578502 0.421498 0.253623 0.17029 0.413043 0.163043 0.583333 0.416667 0.275362 0.289855 0.192029 0.242754 0.481884 0.518116 0.166667 0.503623 0.166667 0.163043 0.67029 0.32971 0.710919 29511.81 -0.229455 0.363636 0.603636 0.189091 0.094545 0.56 0.44 0.225455 0.098182 0.127273 4.789909 9.578182 NMV_2155 2193117 CDS -1 2063867 2064145 279 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-27 16:06:58 no Contains a STAS (Sulphate Transporter and AntiSigma factor antagonist) domain, which is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function. 2 vladimir 0.232975 0.3190 0.268817 0.179211 0.587814 0.412186 0.268817 0.247312 0.333333 0.150538 0.580645 0.419355 0.236559 0.225806 0.247312 0.290323 0.473118 0.526882 0.193548 0.483871 0.225806 0.096774 0.709677 0.290323 0.681487 10089.255 -0.055435 0.358696 0.521739 0.26087 0.065217 0.51087 0.48913 0.271739 0.163043 0.108696 8.985146 9.130435 NMV_2156 2193118 CDS -2 2064202 2064792 591 validated/Curated no putative phospholipid-binding protein MlaC 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 2018-01-27 16:08:28 no 19383799 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. 2 vladimir 0.2978 0.2944 0.228426 0.179357 0.522843 0.477157 0.350254 0.15736 0.35533 0.137056 0.51269 0.48731 0.324873 0.233503 0.167513 0.274112 0.401015 0.598985 0.218274 0.492386 0.162437 0.126904 0.654822 0.345178 0.810247 21112.435 -0.159694 0.326531 0.530612 0.219388 0.071429 0.561224 0.438776 0.204082 0.132653 0.071429 9.891228 9.015306 NMV_2157 2193119 CDS -2 2064829 2065323 495 validated/Curated no putative phospholipid ABC transporter-binding protein MlaD 3 : Putative function from multiple computational evidences t : transporter 11 : Membrane 2018-01-27 16:08:44 no 19383799 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. 1 vladimir 0.212121 0.2646 0.30505 0.218182 0.569697 0.430303 0.230303 0.133333 0.466667 0.169697 0.6 0.4 0.272727 0.230303 0.193939 0.30303 0.424242 0.575758 0.133333 0.430303 0.254545 0.181818 0.684848 0.315152 0.638986 16961.505 0.223171 0.384146 0.579268 0.231707 0.091463 0.634146 0.365854 0.189024 0.085366 0.103659 4.919899 8.676829 NMV_2158 2193120 CDS -3 2065374 2066150 777 validated/Curated no putative phospholipid ABC transporter permease protein MlaE 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:08:53 no 19383799 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. 1 vladimir 0.164736 0.2458 0.307593 0.281853 0.553411 0.446589 0.254826 0.177606 0.355212 0.212355 0.532819 0.467181 0.15444 0.254826 0.177606 0.413127 0.432432 0.567568 0.084942 0.305019 0.389961 0.220077 0.694981 0.305019 0.677174 27398.275 0.886047 0.356589 0.542636 0.313953 0.108527 0.682171 0.317829 0.108527 0.069767 0.03876 9.607323 8.468992 NMV_2159 2193121 CDS -3 2066199 2066999 801 validated/Curated no putative phospholipid import ATP-binding protein MlaF 3 : Putative function from multiple computational evidences t : transporter 2 : Cytoplasmic 2018-01-27 16:09:49 no 19383799 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. 1 vladimir 0.197253 0.2647 0.293383 0.244694 0.558052 0.441948 0.220974 0.243446 0.340824 0.194757 0.58427 0.41573 0.243446 0.220974 0.183521 0.35206 0.404494 0.595506 0.127341 0.329588 0.355805 0.187266 0.685393 0.314607 0.671285 29284.745 0.07218 0.274436 0.481203 0.259398 0.090226 0.593985 0.406015 0.225564 0.112782 0.112782 5.586937 9.233083 NMV_2160 2193122 CDS +1 2067172 2068089 918 validated/Curated no putative HTH-type transcriptional regulator 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-27 16:10:02 no Belongs to the AraC type of Helix-turn-helix (HTH) transcriptional regulators. 1 vladimir 0.235294 0.2778 0.28976 0.197168 0.567538 0.432462 0.24183 0.235294 0.339869 0.183007 0.575163 0.424837 0.284314 0.196078 0.251634 0.267974 0.447712 0.552288 0.179739 0.401961 0.277778 0.140523 0.679739 0.320261 0.629654 34027.37 -0.3 0.321311 0.488525 0.203279 0.12459 0.544262 0.455738 0.262295 0.15082 0.111475 8.550316 9.609836 NMV_2161 2193123 CDS +1 2068120 2068296 177 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:36:46 no 3 vladimir 0.40113 0.1412 0.163842 0.293785 0.305085 0.694915 0.474576 0.084746 0.20339 0.237288 0.288136 0.711864 0.372881 0.237288 0.169492 0.220339 0.40678 0.59322 0.355932 0.101695 0.118644 0.423729 0.220339 0.779661 0.527785 6525.085 -0.812069 0.327586 0.534483 0.137931 0.137931 0.431034 0.568966 0.224138 0.172414 0.051724 10.092674 8.568966 NMV_2162 2193124 CDS +1 2068297 2068686 390 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:36:36 no 3 vladimir 0.407692 0.1103 0.146154 0.335897 0.25641 0.74359 0.361538 0.092308 0.253846 0.292308 0.346154 0.653846 0.446154 0.130769 0.084615 0.338462 0.215385 0.784615 0.415385 0.107692 0.1 0.376923 0.207692 0.792308 0.440277 15444.04 -0.181395 0.178295 0.364341 0.263566 0.162791 0.496124 0.503876 0.286822 0.108527 0.178295 4.516045 9.294574 NMV_2163 2193125 CDS +3 2068695 2068895 201 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-15 16:36:27 no 3 vladimir 0.308458 0.1542 0.248756 0.288557 0.402985 0.597015 0.298507 0.089552 0.38806 0.223881 0.477612 0.522388 0.328358 0.253731 0.19403 0.223881 0.447761 0.552239 0.298507 0.119403 0.164179 0.41791 0.283582 0.716418 0.511503 6994.425 -0.084848 0.409091 0.606061 0.212121 0.106061 0.560606 0.439394 0.166667 0.075758 0.090909 4.952797 9.590909 NMV_2164 2193126 CDS +1 2068930 2070372 1443 validated/Curated no putative glycolaldehyde dehydrogenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.2.1.21 GLYCOLALD-DEHYDROG-RXN PWY0-1280 2019-06-19 14:40:12 no Catalyses the following reaction: glycolaldehyde + NAD(+) + H(2)O <=> glycolate + NADH. 2 vladimir 0.241164 0.2938 0.2772 0.187803 0.571033 0.428967 0.243243 0.180873 0.430353 0.14553 0.611227 0.388773 0.297297 0.234927 0.18711 0.280665 0.422037 0.577963 0.182952 0.465696 0.214137 0.137214 0.679834 0.320166 0.808604 52282.485 -0.139792 0.310417 0.529167 0.216667 0.0875 0.583333 0.416667 0.25625 0.120833 0.135417 5.204765 9.95625 NMV_2165.1 2610589 fCDS +1 2071237 2071521 285 validated/Curated pseudo nalP aspA autotransported serine protease NalP (pseudogene part 1) 1b : Function from experimental evidences in the studied species e : enzyme 10 : Secreted 3.4.21.- 2018-01-23 11:29:45 Is an extracellular subtilisin-related protease containing signal sequence, subtilase, and autotransporter domains. Belongs to MEROPS peptidase family S8 (subtilisin family, clan SB), subfamily S8A. vladimir NMV_2166 2193128 fCDS +2 2071523 2074441 2919 validated/Curated pseudo nalP aspA autotransported serine protease NalP (pseudogene part 2) 1b : Function from experimental evidences in the studied species e : enzyme 10 : Secreted 3.4.21.- 2018-01-23 11:29:33 no Is an extracellular subtilisin-related protease containing signal sequence, subtilase, and autotransporter domains. Belongs to MEROPS peptidase family S8 (subtilisin family, clan SB), subfamily S8A. 2 vladimir 0.259981 0.2808 0.284323 0.174943 0.565076 0.434924 0.280428 0.192795 0.398247 0.12853 0.591042 0.408958 0.290166 0.262902 0.224927 0.222006 0.487829 0.512171 0.209348 0.386563 0.229796 0.174294 0.616358 0.383642 0.628371 108094.695 -0.351657 0.401559 0.592593 0.172515 0.092593 0.542885 0.457115 0.216374 0.114035 0.102339 6.204201 9.502924 NMV_2167 2193129 CDS +1 2075707 2077488 1782 validated/Curated no putative para-aminobenzoate synthase component I (ADC synthase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 2.6.1.85 PABASYN-RXN PWY-6543 2018-01-27 16:14:17 no Catalyses the following reaction: chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate. 2 vladimir 0.227834 0.3440 0.242424 0.185746 0.58642 0.41358 0.215488 0.276094 0.335017 0.173401 0.611111 0.388889 0.281145 0.244108 0.203704 0.271044 0.447811 0.552189 0.186869 0.511784 0.188552 0.112795 0.700337 0.299663 0.698503 65525.95 -0.217707 0.311973 0.504216 0.215852 0.106239 0.561551 0.438449 0.231029 0.11973 0.111298 6.064064 9.397976 NMV_2168 2193130 CDS -2 2077549 2079066 1518 validated/Curated no conserved hypothetical TPR-containing membrane-associated protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-27 16:14:36 no Contains a tetratrico peptide repeat (TPR) structural motif, which mediates protein-protein interactions and the assembly of multiprotein complexes. 1 vladimir 0.208169 0.2141 0.346509 0.231225 0.560606 0.439394 0.185771 0.189723 0.385375 0.23913 0.575099 0.424901 0.320158 0.231225 0.225296 0.22332 0.456522 0.543478 0.118577 0.221344 0.428854 0.231225 0.650198 0.349802 0.565798 56675.3 -0.506337 0.308911 0.516832 0.174257 0.140594 0.556436 0.443564 0.259406 0.154455 0.10495 9.51429 10.043564 NMV_2169 2193131 fCDS +3 2079714 2079806 93 validated/Curated pseudo ISNme1 transposase (pseudogene part 1) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 16:14:47 no Belongs to the IS5 family. 2 vladimir 0.27957 0.2796 0.193548 0.247312 0.473118 0.526882 0.322581 0.258065 0.225806 0.193548 0.483871 0.516129 0.322581 0.193548 0.096774 0.387097 0.290323 0.709677 0.193548 0.387097 0.258065 0.16129 0.645161 0.354839 0.713612 3506.995 0.096667 0.2 0.366667 0.233333 0.133333 0.533333 0.466667 0.233333 0.133333 0.1 6.749474 8.2 NMV_2170 2193132 fCDS +3 2079807 2080721 915 validated/Curated pseudo ISNme1 transposase (pseudogene part 2) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2018-01-27 16:14:57 no Belongs to the IS5 family. 2 vladimir 0.284349 0.2891 0.230585 0.195938 0.519713 0.480287 0.286738 0.258065 0.286738 0.168459 0.544803 0.455197 0.362007 0.204301 0.18638 0.247312 0.390681 0.609319 0.204301 0.405018 0.218638 0.172043 0.623656 0.376344 0.655604 31480.815 -0.452158 0.294964 0.442446 0.21223 0.111511 0.492806 0.507194 0.28777 0.172662 0.115108 8.846825 9.122302 NMV_2171 2193133 CDS -2 2081212 2082846 1635 validated/Curated no groL groEL 60 kDa chaperonin (protein Cpn60; GroEL protein; 63 kDa stress protein; GSP63; HSP60) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2018-01-27 16:15:24 no Type I chaperonins require the concerted action of 2 proteins: chaperonin 60 (Cpn60) and chaperonin 10 (Cpn10). 2 vladimir 0.27156 0.2716 0.278287 0.178593 0.549847 0.450153 0.273394 0.148624 0.482569 0.095413 0.631193 0.368807 0.319266 0.227523 0.154128 0.299083 0.381651 0.618349 0.222018 0.438532 0.198165 0.141284 0.636697 0.363303 0.877588 57452.245 -0.060294 0.314338 0.553309 0.246324 0.036765 0.573529 0.426471 0.268382 0.119485 0.148897 4.903557 9.641544 NMV_2172 2193134 CDS -3 2082939 2083229 291 validated/Curated no groS 10 kDa chaperonin (protein Cpn10; GroES protein) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2020-04-22 13:55:35 no Type I chaperonins require the concerted action of 2 proteins: chaperonin 60 (Cpn60) and chaperonin 10 (Cpn10). 2 vladimir 0.278351 0.2543 0.292096 0.175258 0.546392 0.453608 0.257732 0.14433 0.505155 0.092784 0.649485 0.350515 0.319588 0.175258 0.195876 0.309278 0.371134 0.628866 0.257732 0.443299 0.175258 0.123711 0.618557 0.381443 0.877261 10314.545 -0.165625 0.270833 0.5 0.260417 0.041667 0.583333 0.416667 0.354167 0.177083 0.177083 5.878746 9.447917 NMV_2173 2193135 CDS +2 2083457 2084110 654 validated/Curated no IS1016 group transposase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2008-04-15 16:34:04 no 1 vladimir 0.272171 0.2232 0.249235 0.255352 0.472477 0.527523 0.293578 0.201835 0.311927 0.192661 0.513761 0.486239 0.33945 0.151376 0.206422 0.302752 0.357798 0.642202 0.183486 0.316514 0.229358 0.270642 0.545872 0.454128 0.632297 24719.66 -0.298618 0.248848 0.460829 0.235023 0.129032 0.520737 0.479263 0.313364 0.207373 0.105991 9.650475 9.096774 NMV_2174 2193136 CDS +1 2084323 2085858 1536 validated/Curated no putative sodium-dependent transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2008-04-15 16:33:51 no 1 vladimir 0.166667 0.2520 0.30599 0.275391 0.557943 0.442057 0.232422 0.15625 0.376953 0.234375 0.533203 0.466797 0.1875 0.232422 0.193359 0.386719 0.425781 0.574219 0.080078 0.367188 0.347656 0.205078 0.714844 0.285156 0.69746 54887.36 0.715068 0.336595 0.520548 0.2818 0.1409 0.716243 0.283757 0.136986 0.076321 0.060665 8.501823 8.667319 NMV_2175 2193137 CDS -1 2086007 2087227 1221 validated/Curated no lysA diaminopimelate decarboxylase (DAP decarboxylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 4.1.1.20 DIAMINOPIMDECARB-RXN DAPLYSINESYN-PWY 2018-01-27 16:16:15 no Catalyses the final step of lysine biosynthesis: meso-2,6-diaminoheptanedioate <=> L-lysine + CO(2). 2 vladimir 0.239148 0.2932 0.265356 0.202293 0.558559 0.441441 0.233415 0.201474 0.407862 0.157248 0.609337 0.390663 0.299754 0.226044 0.179361 0.29484 0.405405 0.594595 0.184275 0.452088 0.208845 0.154791 0.660934 0.339066 0.722982 43893.505 0.05665 0.320197 0.514778 0.243842 0.08867 0.603448 0.396552 0.238916 0.110837 0.128079 5.075203 9.672414 NMV_2176 2193138 CDS -3 2087238 2087408 171 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-15 16:33:26 no 2 vladimir 0.263158 0.3216 0.222222 0.192982 0.54386 0.45614 0.210526 0.280702 0.315789 0.192982 0.596491 0.403509 0.298246 0.280702 0.175439 0.245614 0.45614 0.54386 0.280702 0.403509 0.175439 0.140351 0.578947 0.421053 0.672893 6004.755 -0.146429 0.357143 0.5 0.178571 0.107143 0.625 0.375 0.178571 0.125 0.053571 9.519844 8.375 NMV_2177 2193139 CDS +1 2087479 2087802 324 validated/Curated no putative iron-sulfur cluster assembly protein CyaY 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2020-04-21 16:48:47 no Might benvolved in iron-sulfur (Fe-S) cluster assembly. 1 vladimir 0.280864 0.2531 0.283951 0.182099 0.537037 0.462963 0.259259 0.148148 0.425926 0.166667 0.574074 0.425926 0.361111 0.175926 0.212963 0.25 0.388889 0.611111 0.222222 0.435185 0.212963 0.12963 0.648148 0.351852 0.700443 12053.73 -0.431776 0.299065 0.476636 0.17757 0.130841 0.504673 0.495327 0.299065 0.093458 0.205607 4.233101 10.018692 NMV_2178 2193140 CDS +3 2087829 2088845 1017 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2008-04-15 16:33:00 no 3 vladimir 0.26352 0.1908 0.196657 0.349066 0.387414 0.612586 0.292035 0.144543 0.315634 0.247788 0.460177 0.539823 0.20944 0.238938 0.126844 0.424779 0.365782 0.634218 0.289086 0.188791 0.147493 0.374631 0.336283 0.663717 0.513443 36805.305 0.898225 0.310651 0.485207 0.325444 0.14497 0.689349 0.310651 0.130178 0.08284 0.047337 8.930458 8.251479 NMV_2180 2193142 CDS +1 2088871 2089290 420 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:32:46 no 1 vladimir 0.280952 0.2357 0.211905 0.271429 0.447619 0.552381 0.2 0.142857 0.4 0.257143 0.542857 0.457143 0.385714 0.192857 0.121429 0.3 0.314286 0.685714 0.257143 0.371429 0.114286 0.257143 0.485714 0.514286 0.663943 15675.97 -0.136691 0.244604 0.517986 0.251799 0.151079 0.561151 0.438849 0.28777 0.107914 0.179856 4.393425 9.366906 NMV_2181 2193143 CDS +1 2089312 2089818 507 validated/Curated no luxS S-ribosylhomocysteine lyase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.20 : S-adenosyl methionine biosynthesis ; 4.4.1.21 RIBOSYLHOMOCYSTEINASE-RXN PWY-6151$PWY-6153 2018-01-30 14:31:03 no 11895997, 12855737 Catalyses the following reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. 1 vladimir 0.2643 0.2663 0.25641 0.213018 0.522682 0.477318 0.289941 0.230769 0.331361 0.147929 0.56213 0.43787 0.343195 0.213018 0.136095 0.307692 0.349112 0.650888 0.159763 0.35503 0.301775 0.183432 0.656805 0.343195 0.736659 18724.735 -0.204167 0.261905 0.494048 0.22619 0.095238 0.535714 0.464286 0.25 0.125 0.125 5.453636 9.654762 NMV_2182 2193144 CDS +2 2089964 2092756 2793 validated/Curated no polA DNA polymerase I (POL I) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 2.7.7.7 DNA-DIRECTED-DNA-POLYMERASE-RXN$RXN0-4961$RXN0-5039 2018-01-22 15:20:56 no In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilise nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. 2 vladimir 0.251343 0.2997 0.273541 0.175439 0.573219 0.426781 0.239527 0.235231 0.387755 0.137487 0.622986 0.377014 0.330827 0.237379 0.156821 0.274973 0.3942 0.6058 0.183673 0.426423 0.276047 0.113856 0.70247 0.29753 0.700403 102116.145 -0.276774 0.291398 0.496774 0.221505 0.084946 0.553763 0.446237 0.260215 0.125806 0.134409 5.320442 9.554839 NMV_2183 2193145 CDS +1 2093692 2094414 723 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:32:05 no 1 vladimir 0.279391 0.2324 0.230982 0.257261 0.463347 0.536653 0.290456 0.186722 0.311203 0.211618 0.497925 0.502075 0.340249 0.207469 0.141079 0.311203 0.348548 0.651452 0.207469 0.302905 0.240664 0.248963 0.543568 0.456432 0.634326 26689.375 -0.17125 0.270833 0.5 0.233333 0.1 0.533333 0.466667 0.229167 0.1125 0.116667 5.41198 9.083333 NMV_2184 2193146 CDS -2 2094523 2098818 4296 validated/Curated no app autotransporter App 1b : Function from experimental evidences in the studied species e : enzyme 10 : Secreted 5.13 : Virulence associated ; 3.4.21.- 2018-01-23 11:30:39 no 11532129, 12675794 Is a member of the autotransporter family and a homologue to the Hap (Haemophilus adhesion and penetration) protein of H. influenzae. Is secreted and processed by the serine protease activity, which is localised at the amino-terminal domain. Seems to have a minor role in adhesion in N. meningitidis. 1 vladimir 0.295857 0.2605 0.239758 0.203911 0.500233 0.499767 0.303771 0.203212 0.338687 0.15433 0.541899 0.458101 0.354749 0.222067 0.206704 0.21648 0.428771 0.571229 0.22905 0.356145 0.173883 0.240922 0.530028 0.469972 0.624409 156914.39 -0.655206 0.32914 0.549965 0.169811 0.115304 0.483578 0.516422 0.247379 0.145353 0.102027 9.15284 9.348707 NMV_2185 2193147 CDS -1 2098952 2099383 432 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-15 16:31:28 no 2 vladimir 0.25 0.2986 0.270833 0.180556 0.569444 0.430556 0.25 0.236111 0.375 0.138889 0.611111 0.388889 0.284722 0.236111 0.173611 0.305556 0.409722 0.590278 0.215278 0.423611 0.263889 0.097222 0.6875 0.3125 0.576086 15734.36 -0.044755 0.293706 0.503497 0.237762 0.090909 0.573427 0.426573 0.216783 0.111888 0.104895 6.136482 9.559441 NMV_2186 2193148 CDS -2 2099380 2099535 156 validated/Curated no hypothetical membrane-associated protein 5 : Unknown function u : unknown 6 : Inner membrane-associated 2008-04-15 16:31:16 no 2 vladimir 0.282051 0.3269 0.217949 0.173077 0.544872 0.455128 0.288462 0.307692 0.307692 0.096154 0.615385 0.384615 0.307692 0.230769 0.192308 0.269231 0.423077 0.576923 0.25 0.442308 0.153846 0.153846 0.596154 0.403846 0.573793 5620.33 -0.384314 0.27451 0.45098 0.215686 0.078431 0.568627 0.431373 0.294118 0.196078 0.098039 9.989815 8.941176 NMV_2187 2193149 CDS +2 2099666 2101012 1347 validated/Curated no mnmE trmE tRNA modification GTPase MnmE 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 3.6.-.- 2020-04-21 16:51:43 no Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34. 1 vladimir 0.199703 0.2502 0.347439 0.202673 0.597624 0.402376 0.193764 0.213808 0.45657 0.135857 0.670379 0.329621 0.256125 0.242762 0.195991 0.305122 0.438753 0.561247 0.14922 0.293987 0.389755 0.167038 0.683742 0.316258 0.609833 47488.275 0.077455 0.337054 0.542411 0.261161 0.058036 0.584821 0.415179 0.276786 0.127232 0.149554 4.988365 9.319196 NMV_2188 2193150 CDS +2 2103725 2105869 2145 validated/Curated no fetA TonB-dependent enterobactin receptor FetA (FrpB) 1c : Function from experimental evidences in the studied genus rc : receptor 8 : Outer membrane-associated 2008-06-17 17:09:02 no 10217784 1 vladimir 0.285781 0.2937 0.238228 0.182284 0.531935 0.468065 0.309091 0.194406 0.346853 0.14965 0.541259 0.458741 0.359441 0.202797 0.20979 0.227972 0.412587 0.587413 0.188811 0.483916 0.158042 0.169231 0.641958 0.358042 0.769316 79052.815 -0.635294 0.315126 0.539216 0.176471 0.12465 0.488796 0.511204 0.261905 0.158263 0.103641 9.512047 9.431373 NMV_2189 2193151 CDS +1 2106586 2107551 966 validated/Curated no fetB enterobactin uptake system binding lipoprotein FetB 1c : Function from experimental evidences in the studied genus ph : phenotype 11 : Membrane 2018-01-27 16:19:56 no 10217784 FetB is a protein with sequence similarity to the family of periplasmic binding proteins necessary for transporting siderophores through the periplasmic space of Gram-negative bacteria. 2 vladimir 0.266046 0.2816 0.266046 0.186335 0.547619 0.452381 0.257764 0.186335 0.409938 0.145963 0.596273 0.403727 0.329193 0.282609 0.139752 0.248447 0.42236 0.57764 0.21118 0.375776 0.248447 0.164596 0.624224 0.375776 0.7242 34193.51 -0.196262 0.342679 0.538941 0.208723 0.068536 0.560748 0.439252 0.246106 0.11838 0.127726 5.357399 8.791277 NMV_2190 2193152 CDS +3 2107779 2108747 969 validated/Curated no putative ferric enterobactin uptake system permease FetD 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:20:22 no Belongs to the FecCD subfamily of bacterial binding-protein-dependent transport systems family, which includes transport system permease proteins involved in the transport of several compounds across the membrane. 1 vladimir 0.133127 0.2405 0.337461 0.288958 0.577915 0.422085 0.229102 0.235294 0.343653 0.19195 0.578947 0.421053 0.117647 0.235294 0.173375 0.473684 0.408669 0.591331 0.052632 0.250774 0.495356 0.201238 0.74613 0.25387 0.634611 34434.255 1.159006 0.298137 0.509317 0.378882 0.080745 0.736025 0.263975 0.099379 0.055901 0.043478 9.640114 8.437888 NMV_2191 2193153 CDS +1 2108737 2109711 975 validated/Curated no putative feric enterobactin uptake system permease FetC 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:20:36 no Belongs to the FecCD subfamily of bacterial binding-protein-dependent transport systems family, which includes transport system permease proteins involved in the transport of several compounds across the membrane. 2 vladimir 0.166154 0.2790 0.277949 0.276923 0.556923 0.443077 0.209231 0.243077 0.323077 0.224615 0.566154 0.433846 0.169231 0.215385 0.181538 0.433846 0.396923 0.603077 0.12 0.378462 0.329231 0.172308 0.707692 0.292308 0.606727 35320.695 0.835494 0.302469 0.484568 0.333333 0.12963 0.691358 0.308642 0.138889 0.089506 0.049383 9.374687 8.487654 NMV_2192 2193154 CDS +3 2109756 2110382 627 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:29:33 no 2 vladimir 0.213716 0.3604 0.269537 0.1563 0.629984 0.370016 0.196172 0.263158 0.421053 0.119617 0.684211 0.315789 0.229665 0.267943 0.220096 0.282297 0.488038 0.511962 0.215311 0.550239 0.167464 0.066986 0.717703 0.282297 0.661427 22182.515 0.004327 0.360577 0.543269 0.211538 0.081731 0.610577 0.389423 0.216346 0.110577 0.105769 6.192238 9.788462 NMV_2193 2193155 CDS +1 2110465 2111223 759 validated/Curated no putative ferric enterobactin uptake system ATP-binding protein FetE 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 2008-04-15 16:29:23 no 2 vladimir 0.251647 0.3544 0.218709 0.175231 0.573123 0.426877 0.296443 0.272727 0.320158 0.110672 0.592885 0.407115 0.304348 0.201581 0.173913 0.320158 0.375494 0.624506 0.15415 0.588933 0.162055 0.094862 0.750988 0.249012 0.736148 28253.495 -0.13373 0.269841 0.47619 0.253968 0.099206 0.539683 0.460317 0.257937 0.146825 0.111111 7.285133 9.714286 NMV_2194 2193156 CDS +1 2111539 2112756 1218 validated/Curated no nadA NadA autotransporter adhesin 1b : Function from experimental evidences in the studied species ph : phenotype 8 : Outer membrane-associated 2018-01-27 16:21:13 no 12045242, 15660996 Is one of the antigens in the Bexsero vaccine (GNA1994) that induces cross-reactive bactericidal antibodies against a number of N. meningitidis strains. The proteins contributes to adhesion to and invasion of epithelial cells. 1 vladimir 0.332512 0.2553 0.226601 0.18555 0.481938 0.518062 0.330049 0.078818 0.477833 0.1133 0.55665 0.44335 0.374384 0.334975 0.091133 0.199507 0.426108 0.573892 0.293103 0.352217 0.110837 0.243842 0.463054 0.536946 0.713652 42503.17 -0.410123 0.4 0.622222 0.167901 0.059259 0.474074 0.525926 0.293827 0.130864 0.162963 4.87162 9.153086 NMV_2195 2193157 CDS -3 2112822 2113160 339 validated/Curated no glnB nitrogen regulatory protein P-II 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 1.5.1.2 : Glutamine ; 2018-01-27 16:22:04 no PII, a tetrameric protein encoded by the glnB gene, is a component of the adenylation cascade involved in the regulation of glutamine synthetase (GS) activity. In nitrogen-limiting conditions, when the ratio of glutamine to 2-ketoglutarate decreases, P-II is uridylylated on a tyrosine residue to form P-II-UMP. P-II-UMP allows the deadenylation of GS, thus activating the enzyme. 1 vladimir 0.238938 0.2271 0.348083 0.185841 0.575221 0.424779 0.274336 0.141593 0.495575 0.088496 0.637168 0.362832 0.300885 0.185841 0.176991 0.336283 0.362832 0.637168 0.141593 0.353982 0.371681 0.132743 0.725664 0.274336 0.620836 12280.795 0.035714 0.258929 0.482143 0.285714 0.0625 0.580357 0.419643 0.348214 0.169643 0.178571 5.502129 9.482143 NMV_2196 2193158 CDS +2 2113310 2117296 3987 validated/Curated no purL phosphoribosylformylglycinamidine synthase (FGAM synthase; FGAMS; formylglycinamide ribotide amidotransferase; FGARAT; formylglycinamide ribotide synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.5.3 FGAMSYN-RXN PWY-6121 2018-01-27 16:22:24 no Catalyses the following reaction: ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O <=> ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. 1 vladimir 0.24003 0.2912 0.267118 0.201655 0.558315 0.441685 0.243792 0.204665 0.380737 0.170805 0.585403 0.414597 0.30775 0.231001 0.179834 0.281415 0.410835 0.589165 0.168548 0.437923 0.240783 0.152746 0.678706 0.321294 0.753626 144852.345 -0.196913 0.307982 0.521084 0.212349 0.098645 0.560994 0.439006 0.243976 0.115964 0.128012 5.168022 9.446536 NMV_2197 2193159 CDS +3 2117391 2118143 753 validated/Curated no gloB hydroxyacylglutathione hydrolase (glyoxalase II; Glx II) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.23 : Methylglyoxal metabolism ; 3.1.2.6 GLYOXII-RXN PWY-5386 2020-04-21 16:53:35 no Catalyses the following reaction: S-(2-hydroxyacyl)glutathione + H(2)O <=> glutathione + 2-hydroxy carboxylate. 2 vladimir 0.229748 0.3758 0.229748 0.164675 0.605578 0.394422 0.219124 0.270916 0.354582 0.155378 0.625498 0.374502 0.282869 0.290837 0.171315 0.25498 0.462151 0.537849 0.187251 0.565737 0.163347 0.083665 0.729084 0.270916 0.692818 27751.265 -0.2272 0.328 0.54 0.192 0.144 0.552 0.448 0.236 0.124 0.112 5.700478 10.036 NMV_2198 2193160 CDS +2 2118377 2119831 1455 validated/Curated no putative divalent cation transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:23:13 no Belongs to the MgtE family of magnesium transporters. Members of this family probably transport Mg2+ or other divalent cations into the cell. 2 vladimir 0.220619 0.2832 0.296907 0.199313 0.580069 0.419931 0.212371 0.210309 0.453608 0.123711 0.663918 0.336082 0.286598 0.210309 0.142268 0.360825 0.352577 0.647423 0.162887 0.428866 0.294845 0.113402 0.723711 0.276289 0.708684 52918.665 0.201446 0.256198 0.518595 0.295455 0.06405 0.592975 0.407025 0.268595 0.090909 0.177686 4.286079 9.592975 NMV_2199 2193161 CDS -3 2119917 2120825 909 validated/Curated no hslO 33 kDa chaperonin (heat shock protein 33 homolog; HSP33) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.4 : Chaperoning, folding ; 2018-01-27 16:23:37 no Is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localised protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidising conditions like H2O2 cause disulphide bonds to form in Hsp33, a process that leads to the activation of its chaperone function. 2 vladimir 0.214521 0.2574 0.330033 0.19802 0.587459 0.412541 0.184818 0.240924 0.442244 0.132013 0.683168 0.316832 0.30033 0.194719 0.19802 0.306931 0.392739 0.607261 0.158416 0.336634 0.349835 0.155116 0.686469 0.313531 0.695991 33175.295 -0.117881 0.284768 0.516556 0.251656 0.086093 0.559603 0.440397 0.278146 0.119205 0.15894 4.763206 9.917219 NMV_2200 2193162 CDS +1 2121070 2121825 756 validated/Curated no putative murein DD-endopeptidase MepH 3 : Putative function from multiple computational evidences e : enzyme 11 : Membrane 1.6.7 : Peptidoglycan (murein) ; 3.4.-.- RXN0-3461 2018-01-23 11:20:17 no A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. 2 vladimir 0.208995 0.3254 0.279101 0.186508 0.604497 0.395503 0.253968 0.265873 0.34127 0.138889 0.607143 0.392857 0.246032 0.230159 0.242063 0.281746 0.472222 0.527778 0.126984 0.480159 0.253968 0.138889 0.734127 0.265873 0.579535 27618.57 -0.248606 0.298805 0.521912 0.199203 0.095618 0.585657 0.414343 0.223108 0.139442 0.083665 10.243919 10 NMV_2201 2193163 CDS +1 2121844 2122062 219 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:18:44 no 2 vladimir 0.278539 0.2283 0.283105 0.210046 0.511416 0.488584 0.246575 0.219178 0.356164 0.178082 0.575342 0.424658 0.383562 0.164384 0.164384 0.287671 0.328767 0.671233 0.205479 0.30137 0.328767 0.164384 0.630137 0.369863 0.675493 8305.195 -0.390278 0.222222 0.416667 0.208333 0.083333 0.555556 0.444444 0.291667 0.097222 0.194444 4.299217 10.402778 NMV_2202 2193164 CDS +1 2122207 2122554 348 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-27 16:24:22 no Belongs to an uncharacterised family of proteins, which contains LrgA that has been hypothesised to export murein hydrolases. 2 vladimir 0.163793 0.2989 0.281609 0.255747 0.58046 0.41954 0.258621 0.241379 0.310345 0.189655 0.551724 0.448276 0.12931 0.224138 0.206897 0.439655 0.431034 0.568966 0.103448 0.431034 0.327586 0.137931 0.758621 0.241379 0.586087 12381.46 1.145217 0.330435 0.504348 0.382609 0.086957 0.713043 0.286957 0.113043 0.069565 0.043478 8.63459 8.069565 NMV_2203 2193165 CDS +3 2122551 2123243 693 validated/Curated no conserved hypothetical membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-27 16:24:39 no Homologous to LrgB. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control murein hydrolase activity and penicillin tolerance. 2 vladimir 0.181818 0.3175 0.262626 0.238095 0.580087 0.419913 0.285714 0.238095 0.337662 0.138528 0.575758 0.424242 0.168831 0.268398 0.160173 0.402597 0.428571 0.571429 0.090909 0.445887 0.290043 0.17316 0.735931 0.264069 0.609935 24583.405 0.864348 0.326087 0.526087 0.33913 0.091304 0.7 0.3 0.113043 0.082609 0.030435 10.054756 8.773913 NMV_2204 2193166 CDS +3 2123310 2124530 1221 validated/Curated no argJ arginine biosynthesis bifunctional protein ArgJ [includes: glutamate N-acetyltransferase (ornithine acetyltransferase; ornithine transacetylase; OATase) and amino acid acetyltransferase (N-acetylglutamate synthase; AGS)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 2.3.1.35, 2.3.1.1 GLUTAMATE-N-ACETYLTRANSFERASE-RXN$N-ACETYLTRANSFER-RXN ARGSYN-PWY$ARGSYNBSUB-PWY$GLUTORN-PWY 2018-01-27 16:25:11 no Catalyses two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate. 2 vladimir 0.231777 0.3669 0.248157 0.153153 0.61507 0.38493 0.277641 0.201474 0.41769 0.103194 0.619165 0.380835 0.272727 0.309582 0.152334 0.265356 0.461916 0.538084 0.144963 0.589681 0.174447 0.090909 0.764128 0.235872 0.727037 42809.995 0.035714 0.376847 0.58867 0.216749 0.071429 0.576355 0.423645 0.219212 0.110837 0.108374 5.664055 9.463054 NMV_2205 2193167 CDS +2 2124590 2125999 1410 validated/Curated no putative H(+)/Cl(-) exchange transporter ClcA 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.1.A.11 : The Chloride Channel (ClC) Family ; 2018-01-27 16:25:37 no Belongs to the chloride channel (CLC) family of proteins, which constitute an evolutionarily well-conserved family of voltage-gated channels. 2 vladimir 0.17234 0.3227 0.29078 0.214184 0.613475 0.386525 0.204255 0.265957 0.344681 0.185106 0.610638 0.389362 0.170213 0.287234 0.208511 0.334043 0.495745 0.504255 0.142553 0.414894 0.319149 0.123404 0.734043 0.265957 0.651166 50075.94 0.495736 0.373134 0.496802 0.240938 0.123667 0.697228 0.302772 0.132196 0.098081 0.034115 10.48745 8.929638 NMV_2206 2193168 CDS +2 2126189 2127580 1392 validated/Curated partial truncated ATP-dependent DNA helicase HrpA (N-terminal 38% of the protein) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.6.4.13 RXN-11109 2018-01-27 16:26:45 no Is interrupted by a putative type II restriction-modification system. 1 vladimir 0.247375 0.3130 0.244751 0.194882 0.557743 0.442257 0.230315 0.248031 0.346457 0.175197 0.594488 0.405512 0.301181 0.244094 0.165354 0.28937 0.409449 0.590551 0.21063 0.44685 0.222441 0.120079 0.669291 0.330709 0.655399 56833.12 -0.244379 0.282051 0.461538 0.232742 0.098619 0.5286 0.4714 0.301775 0.16568 0.136095 8.097435 9.416174 NMV_2207 2193169 CDS +2 2127638 2128696 1059 validated/Curated no putative type II restriction-modification system enzyme Res 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2008-04-15 16:16:49 no 3 vladimir 0.321058 0.1643 0.184136 0.3305 0.348442 0.651558 0.345609 0.13881 0.246459 0.269122 0.385269 0.614731 0.311615 0.21813 0.147309 0.322946 0.365439 0.634561 0.305949 0.135977 0.15864 0.399433 0.294618 0.705382 0.53115 39804.215 -0.05767 0.267045 0.482955 0.247159 0.107955 0.519886 0.480114 0.221591 0.107955 0.113636 5.413048 8.6875 NMV_2208 2193170 CDS +1 2128693 2129685 993 validated/Curated no putative type II restriction-modification system enzyme Mod 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.37 DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2018-01-27 16:27:12 no Is a C-5 cytosine-specific DNA methylase, an enzyme that specifically methylates the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. 3 vladimir 0.305136 0.1782 0.210473 0.306143 0.388721 0.611279 0.29003 0.175227 0.302115 0.232628 0.477341 0.522659 0.347432 0.202417 0.160121 0.29003 0.362538 0.637462 0.277946 0.1571 0.169184 0.39577 0.326284 0.673716 0.54546 37611.435 -0.317576 0.248485 0.475758 0.209091 0.136364 0.542424 0.457576 0.263636 0.133333 0.130303 5.638954 9.7 NMV_2209 2193171 CDS +3 2129850 2133200 3351 validated/Curated partial truncated ATP-dependent DNA helicase HrpA (C-terminal 62% of the protein) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1 : DNA replication ; 3.6.4.13 RXN-11109 2018-01-31 20:35:50 no Is interrupted by a putative type II restriction-modification system. 2 vladimir 0.2618 0.3269 0.241571 0.169745 0.568455 0.431545 0.233949 0.299912 0.331574 0.134565 0.631486 0.368514 0.337731 0.263852 0.156552 0.241865 0.420405 0.579595 0.21372 0.416887 0.236588 0.132806 0.653474 0.346526 0.658959 127839.545 -0.557306 0.276408 0.460387 0.18838 0.096831 0.507042 0.492958 0.283451 0.15493 0.128521 8.185127 9.384683 NMV_2210 2193172 CDS -2 2133223 2133645 423 validated/Curated no putative very-short-patch-repair endonuclease 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.2.2 : DNA ; 3.1.-.- 2018-01-22 20:39:15 no May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. 1 vladimir 0.352246 0.1584 0.217494 0.271868 0.375887 0.624113 0.382979 0.12766 0.262411 0.22695 0.390071 0.609929 0.375887 0.141844 0.191489 0.29078 0.333333 0.666667 0.297872 0.205674 0.198582 0.297872 0.404255 0.595745 0.59755 16613.785 -0.577143 0.207143 0.4 0.214286 0.142857 0.471429 0.528571 0.364286 0.242857 0.121429 9.743935 9.135714 NMV_2211 2193173 CDS -2 2133649 2135295 1647 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:15:57 no 3 vladimir 0.358227 0.1536 0.216758 0.271403 0.37037 0.62963 0.342441 0.138434 0.307832 0.211293 0.446266 0.553734 0.404372 0.180328 0.145719 0.269581 0.326047 0.673953 0.327869 0.142077 0.196721 0.333333 0.338798 0.661202 0.507653 62945.795 -0.620985 0.235401 0.436131 0.213504 0.114964 0.459854 0.540146 0.319343 0.160584 0.158759 5.70742 9.001825 NMV_2212 2193174 CDS -1 2135309 2136313 1005 validated/Curated no putative cytosine-specific methyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2.1.1.37 DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN 2020-04-21 13:03:09 no Catalyses the following reaction: S-adenosyl-L-methionine + DNA <=> S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. Is the modification methylase of a restriction-modification system. 3 vladimir 0.321023 0.1676 0.238636 0.272727 0.40625 0.59375 0.335227 0.147727 0.3125 0.204545 0.460227 0.539773 0.340909 0.170455 0.198864 0.289773 0.369318 0.630682 0.286932 0.184659 0.204545 0.323864 0.389205 0.610795 0.498881 39593.95 -0.348433 0.262108 0.458689 0.207977 0.116809 0.535613 0.464387 0.282051 0.156695 0.125356 8.676567 9.131054 NMV_2213 2193175 CDS -1 2136770 2136913 144 validated/Curated partial truncated ISNme1 transposase (internal fragment corresponding to 14% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-27 16:28:15 no Belongs to the IS5 family. 2 vladimir 0.303571 0.3274 0.22619 0.142857 0.553571 0.446429 0.285714 0.303571 0.321429 0.089286 0.625 0.375 0.339286 0.303571 0.107143 0.25 0.410714 0.589286 0.285714 0.375 0.25 0.089286 0.625 0.375 0.660917 5903.61 -0.236364 0.327273 0.490909 0.236364 0 0.509091 0.490909 0.236364 0.127273 0.109091 8.136848 8.527273 NMV_2214 2193176 CDS -2 2136910 2137203 294 validated/Curated partial truncated ISNme1 transposase (N-terminal third of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2018-01-27 16:28:25 no Belongs to the IS5 family. 2 vladimir 0.249322 0.3469 0.197832 0.205962 0.544715 0.455285 0.268293 0.349593 0.170732 0.211382 0.520325 0.479675 0.317073 0.186992 0.219512 0.276423 0.406504 0.593496 0.162602 0.504065 0.203252 0.130081 0.707317 0.292683 0.629735 14633.385 -0.57623 0.213115 0.401639 0.196721 0.147541 0.491803 0.508197 0.278689 0.180328 0.098361 9.419762 9.762295 NMV_2215 2193177 CDS +2 2137454 2137777 324 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2018-01-27 16:28:43 no Is homologous to the N-terminus of numerous cytosolic 5'-nucleotidases. 3 vladimir 0.355556 0.2000 0.155556 0.288889 0.355556 0.644444 0.344444 0.177778 0.2 0.277778 0.377778 0.622222 0.366667 0.233333 0.1 0.3 0.333333 0.666667 0.355556 0.188889 0.166667 0.288889 0.355556 0.644444 0.459638 10312.56 -0.380899 0.258427 0.404494 0.191011 0.146067 0.483146 0.516854 0.269663 0.179775 0.089888 9.375328 8.640449 NMV_2216 2193178 CDS -3 2137938 2138387 450 validated/Curated no comP minor pilin ComP 1a : Function from experimental evidences in the studied strain s : structure 3 : Fimbrial 6.5 : Pilus ; 2020-04-25 14:49:40 no 10200956, 23386723, 24385921, 27161979 Minor pilus subunit that assembles within the filaments in a similar way to PilE, but is not required for pilus biogenesis. Is required for DNA uptake during transformation by acting as the DUS receptor. 3 vladimir 0.313333 0.1378 0.24 0.308889 0.377778 0.622222 0.353333 0.113333 0.286667 0.246667 0.4 0.6 0.34 0.173333 0.153333 0.333333 0.326667 0.673333 0.246667 0.126667 0.28 0.346667 0.406667 0.593333 0.470282 16868.12 -0.025503 0.255034 0.463087 0.241611 0.114094 0.557047 0.442953 0.261745 0.161074 0.100671 9.371803 8.651007 NMV_2217 2193179 CDS -3 2138475 2138774 300 validated/Curated no comE4 DNA-binding competence protein ComE4 1c : Function from experimental evidences in the studied genus f : factor 11 : Membrane 2018-01-27 16:30:26 no 11325945 ComE is a DNA-binding protein involved in neisserial competence. The comE gene is present in four copies in the genome, located downstream of each of the rRNA operons. 1 vladimir 0.230108 0.2473 0.301075 0.221505 0.548387 0.451613 0.270968 0.2 0.341935 0.187097 0.541935 0.458065 0.245161 0.296774 0.167742 0.290323 0.464516 0.535484 0.174194 0.245161 0.393548 0.187097 0.63871 0.36129 0.539299 16485.005 0.093506 0.344156 0.512987 0.201299 0.084416 0.642857 0.357143 0.227273 0.175325 0.051948 10.242104 8.863636 NMV_5S_1 2194884 rRNA -1 2138975 2139091 117 validated/Curated no ribosomal RNA 5S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:48 vladimir NMV_23S_1 2194880 rRNA -1 2139185 2142087 2903 validated/Curated no ribosomal RNA 23S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:04:55 vladimir NMV_tRNA_37 2194852 tRNA -1 2142483 2142558 76 validated/Curated no Ala tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:59:06 no tRNA Ala anticodon TGC. vladimir NMV_tRNA_36 2194851 tRNA -1 2142564 2142640 77 validated/Curated no Ile tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:59:16 no tRNA Ile anticodon GAT. vladimir NMV_16S_1 2194876 rRNA -1 2142738 2144282 1545 validated/Curated no ribosomal RNA 16S 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:05:03 vladimir NMNmiscRNA0145 54894439 misc_RNA +1 2144498 2144611 114 validated/Curated no ncRNA 2b : Function from indirect experimental evidences (e.g. phenotypes) 2018-01-28 20:51:56 28334889 Function unknown but has three paralogs. vladimir NMV_2221 2193183 CDS -2 2144620 2145282 663 validated/Curated no putative RNA pseudouridine synthase (RNA-uridine isomerase; RNA pseudouridylate synthase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 5.4.99.- 2018-01-23 13:20:33 no Pseudouridine synthases are responsible for synthesis of pseudouridine from uracil in 23S rRNA. 1 vladimir 0.312217 0.2443 0.244344 0.199095 0.488688 0.511312 0.334842 0.217195 0.280543 0.167421 0.497738 0.502262 0.316742 0.171946 0.217195 0.294118 0.38914 0.61086 0.285068 0.343891 0.235294 0.135747 0.579186 0.420814 0.600224 25040.965 -0.343182 0.277273 0.4 0.222727 0.113636 0.509091 0.490909 0.277273 0.172727 0.104545 9.616829 8.881818 NMV_2222 2193184 CDS -1 2145308 2145820 513 validated/Curated no coaD kdtB phosphopantetheine adenylyltransferase (pantetheine-phosphate adenylyltransferase; PPAT; dephospho-CoA pyrophosphorylase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.5 : Coenzyme A ; 2.7.7.3 PANTEPADENYLYLTRAN-RXN COA-PWY 2018-01-27 16:31:00 no Catalyses the fourth (and penultimate) step of coenzyme A biosynthesis: ATP + pantetheine 4'-phosphate <=> diphosphate + 3'-dephospho-CoA. 1 vladimir 0.253411 0.2846 0.243665 0.218324 0.528265 0.471735 0.263158 0.239766 0.333333 0.163743 0.573099 0.426901 0.298246 0.233918 0.169591 0.298246 0.403509 0.596491 0.19883 0.380117 0.22807 0.192982 0.608187 0.391813 0.638565 19542.605 -0.316471 0.241176 0.476471 0.211765 0.129412 0.541176 0.458824 0.276471 0.141176 0.135294 5.674843 10.376471 NMV_2223 2193185 CDS -1 2145944 2146627 684 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-15 16:11:43 no 2 vladimir 0.188596 0.2939 0.251462 0.266082 0.545322 0.454678 0.267544 0.179825 0.350877 0.201754 0.530702 0.469298 0.179825 0.245614 0.157895 0.416667 0.403509 0.596491 0.118421 0.45614 0.245614 0.179825 0.701754 0.298246 0.687604 24452.85 0.905286 0.348018 0.515419 0.295154 0.145374 0.696035 0.303965 0.118943 0.07489 0.044053 8.972755 8.718062 NMV_2224 2193186 CDS -1 2146784 2147050 267 validated/Curated no putative Fe(2+) trafficking protein 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-27 16:31:21 no Might serve to protect Fe-S clusters from oxidative damage. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide (a DNA damaging agent) is prevented. 2 vladimir 0.258427 0.2697 0.280899 0.191011 0.550562 0.449438 0.213483 0.269663 0.348315 0.168539 0.617978 0.382022 0.359551 0.202247 0.168539 0.269663 0.370787 0.629213 0.202247 0.337079 0.325843 0.134831 0.662921 0.337079 0.694889 10179.245 -0.504545 0.227273 0.431818 0.159091 0.125 0.568182 0.431818 0.25 0.125 0.125 5.787636 10.704545 NMV_2225 2193187 CDS -1 2147123 2147593 471 validated/Curated no rlmH ribosomal RNA large subunit methyltransferase H 2a : Function from experimental evidences in other organisms e : enzyme 1 : Unknown 2.1.1.177 RXN-11592 2018-01-27 16:31:45 no 18755836, 18755835 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. 2 vladimir 0.237792 0.3312 0.265393 0.165605 0.596603 0.403397 0.216561 0.280255 0.394904 0.10828 0.675159 0.324841 0.312102 0.210191 0.184713 0.292994 0.394904 0.605096 0.184713 0.503185 0.216561 0.095541 0.719745 0.280255 0.74294 17463.535 -0.238462 0.269231 0.455128 0.224359 0.102564 0.570513 0.429487 0.288462 0.173077 0.115385 9.104668 10.141026 NMV_2226 2193188 CDS -2 2147647 2148033 387 validated/Curated no rsfS ribosomal silencing factor 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 3.1.3.1 : Translation attenuation and efficiency ; 2018-01-27 16:33:14 no Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. 2 vladimir 0.276486 0.2817 0.26615 0.175711 0.547804 0.452196 0.271318 0.193798 0.44186 0.093023 0.635659 0.364341 0.341085 0.193798 0.162791 0.302326 0.356589 0.643411 0.217054 0.457364 0.193798 0.131783 0.651163 0.348837 0.648896 14015.225 -0.153125 0.28125 0.53125 0.234375 0.085938 0.539062 0.460938 0.28125 0.109375 0.171875 4.469475 9.070312 NMV_2227 2193189 CDS -1 2148092 2148697 606 validated/Curated no putative nicotinate-nucleotide adenylyltransferase (deamido-NAD(+) pyrophosphorylase; deamido-NAD(+) diphosphorylase; nicotinate mononucleotide adenylyltransferase; NaMN adenylyltransferase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.7 : Nicotinamide adenine dinucleotide (NAD) ; 2.7.7.18 NICONUCADENYLYLTRAN-RXN PYRIDNUCSAL-PWY$PYRIDNUCSYN-PWY 2018-01-27 16:33:52 no Catalyses the synthesis of the immediate precursor of NAD by the de novo pathway: ATP + nicotinate ribonucleotide <=> diphosphate + deamido-NAD(+). 2 vladimir 0.221122 0.3284 0.268977 0.181518 0.59736 0.40264 0.227723 0.262376 0.361386 0.148515 0.623762 0.376238 0.282178 0.247525 0.19802 0.272277 0.445545 0.554455 0.153465 0.475248 0.247525 0.123762 0.722772 0.277228 0.705147 22268.49 -0.20796 0.318408 0.497512 0.199005 0.129353 0.562189 0.437811 0.258706 0.149254 0.109453 6.823601 9.363184 NMV_2228 2193190 CDS -2 2148694 2149293 600 validated/Curated no putative carbonic anhydrase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 4.2.1.1 CARBODEHYDRAT-RXN$RXN0-5224 PWYQT-4429 2020-04-25 14:52:14 no Zinc metalloenzyme, which catalyses the reversible hydration of carbon dioxide. in N. meningitidis, it modulates pilus-mediated properties without being required for pilus biogenesis. 1 vladimir 0.223333 0.2567 0.298333 0.221667 0.555 0.445 0.24 0.24 0.39 0.13 0.63 0.37 0.295 0.165 0.205 0.335 0.37 0.63 0.135 0.365 0.3 0.2 0.665 0.335 0.613475 22080.42 -0.058794 0.256281 0.492462 0.276382 0.100503 0.562814 0.437186 0.296482 0.145729 0.150754 5.311043 9.59799 NMV_2229 2193191 CDS -1 2149322 2150863 1542 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2015-11-19 16:44:25 no 1 vladimir 0.115288 0.2231 0.387218 0.274436 0.610276 0.389724 0.120301 0.219925 0.406015 0.253759 0.62594 0.37406 0.131579 0.296992 0.197368 0.37406 0.494361 0.505639 0.093985 0.152256 0.558271 0.195489 0.710526 0.289474 0.585875 57252.88 0.867232 0.350282 0.544256 0.291902 0.12806 0.766478 0.233522 0.116761 0.067797 0.048964 9.191612 9.355932 NMV_2230 2193192 CDS +1 2151256 2152641 1386 validated/Curated no putative gluconate permease 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:34:46 no Belongs to a family of integral membrane permeases that are involved in gluconate uptake. 2 vladimir 0.171717 0.3203 0.279221 0.228716 0.599567 0.400433 0.24026 0.218615 0.383117 0.158009 0.601732 0.398268 0.134199 0.281385 0.179654 0.404762 0.461039 0.538961 0.140693 0.461039 0.274892 0.123377 0.735931 0.264069 0.686683 47553.68 0.991323 0.37744 0.557484 0.32538 0.08243 0.720174 0.279826 0.117137 0.065076 0.052061 7.832649 8.197397 NMV_2231 2193193 CDS +2 2152661 2153179 519 validated/Curated no putative gluconokinase (gluconate kinase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.1.1.2 : 2,5-ketogluconate metabolism ; 2.7.1.12 GLUCONOKIN-RXN GLUCONSUPER-PWY 2018-01-27 16:35:39 no Catalyses the following reaction: ATP + D-gluconate <=> ADP + 6-phospho-D-gluconate. 2 vladimir 0.248555 0.3044 0.27553 0.171484 0.579961 0.420039 0.254335 0.254335 0.364162 0.127168 0.618497 0.381503 0.32948 0.219653 0.202312 0.248555 0.421965 0.578035 0.16185 0.439306 0.260116 0.138728 0.699422 0.300578 0.691875 18945.785 -0.388372 0.313953 0.494186 0.186047 0.098837 0.55814 0.44186 0.261628 0.133721 0.127907 5.663734 10.122093 NMV_2232 2193194 CDS -2 2153518 2154435 918 validated/Curated no thrB homoserine kinase (HSK; HK) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.8 : Threonine ; 2.7.1.39 HOMOSERKIN-RXN HOMOSER-THRESYN-PWY 2018-01-27 16:36:04 no Catalyses the following reaction: ATP + L-homoserine <=> ADP + O-phospho-L-homoserine. It is required for the biosynthesis of threonine from aspartate. 1 vladimir 0.191721 0.2397 0.309368 0.259259 0.54902 0.45098 0.205882 0.202614 0.369281 0.222222 0.571895 0.428105 0.287582 0.228758 0.176471 0.30719 0.405229 0.594771 0.081699 0.287582 0.382353 0.248366 0.669935 0.330065 0.655298 33705.22 0.030164 0.304918 0.518033 0.219672 0.127869 0.6 0.4 0.236066 0.108197 0.127869 4.94532 9.347541 NMV_2233 2193195 CDS -2 2154472 2155188 717 validated/Curated no ubiG ubiquinone biosynthesis O-methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.11 : Menaquinone (MK), ubiquinone (Q) ; 2.1.1.64, 2.1.1.222 2-OCTAPRENYL-6-OHPHENOL-METHY-RXN$DHHB-METHYLTRANSFER-RXN PWY-6708 2020-04-21 16:56:10 no O-methyltransferase that catalyses the 2 O-methylation steps in the ubiquinone biosynthetic pathway 1 vladimir 0.227336 0.2483 0.305439 0.218968 0.553696 0.446304 0.238494 0.179916 0.393305 0.188285 0.573222 0.426778 0.32636 0.225941 0.16318 0.284519 0.389121 0.610879 0.117155 0.338912 0.359833 0.1841 0.698745 0.301255 0.691723 26595.535 -0.160924 0.285714 0.508403 0.201681 0.121849 0.57563 0.42437 0.302521 0.155462 0.147059 5.768517 9.823529 NMV_2234 2193196 CDS +2 2155352 2156593 1242 validated/Curated no putative aromatic amino acid transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 4.2.A.42 : The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family ; 2008-04-15 16:08:36 no 2 vladimir 0.194847 0.3414 0.236715 0.227053 0.5781 0.4219 0.2657 0.181159 0.345411 0.207729 0.52657 0.47343 0.178744 0.263285 0.176328 0.381643 0.439614 0.560386 0.140097 0.57971 0.188406 0.091787 0.768116 0.231884 0.720206 44246.38 0.768039 0.358354 0.544794 0.285714 0.140436 0.707022 0.292978 0.106538 0.065375 0.041162 9.179863 8.469734 NMV_2235 2193197 CDS +2 2156726 2157289 564 validated/Curated no gmhB D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase (D,D-heptose 1,7-bisphosphate phosphatase) 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.6.3.2 : Core region ; 3.1.3.82 RXN0-4361 PWY0-1241 2018-01-23 13:44:58 no Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. It is essential for lipooligosaccharide (LOS) core biosynthesis. 2 vladimir 0.262411 0.3209 0.244681 0.171986 0.565603 0.434397 0.260638 0.239362 0.37234 0.12766 0.611702 0.388298 0.340426 0.207447 0.175532 0.276596 0.382979 0.617021 0.18617 0.515957 0.18617 0.111702 0.702128 0.297872 0.730636 20682.55 -0.32139 0.283422 0.518717 0.208556 0.101604 0.534759 0.465241 0.262032 0.128342 0.13369 5.290108 9.55615 NMV_2236 2193198 CDS +3 2157318 2158061 744 validated/Curated no nlaB 1-acyl-sn-glycerol-3-phosphate acyltransferase NlaB (1-AGP acyltransferase; 1-AGPAT; lysophosphatidic acid acyltransferase; LPAAT) 1b : Function from experimental evidences in the studied species e : enzyme 9 : Periplasmic 1.6.1 : Phospholipid ; 2.3.1.51 1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN$RXN-1623$RXN0-5514$RXN0-6705 PWY-5667$PWY-5981$PWY0-1319$PWY4FS-7$PWY4FS-8 2020-02-23 20:06:39 no 10361297 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. 2 vladimir 0.244624 0.3172 0.239247 0.198925 0.556452 0.443548 0.298387 0.258065 0.282258 0.16129 0.540323 0.459677 0.270161 0.209677 0.189516 0.330645 0.399194 0.600806 0.165323 0.483871 0.245968 0.104839 0.729839 0.270161 0.628613 27920.96 0.031174 0.251012 0.421053 0.246964 0.121457 0.619433 0.380567 0.234818 0.149798 0.08502 9.573036 9.072874 NMV_2237 2193199 CDS +2 2158058 2158747 690 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-15 16:07:32 no 2 vladimir 0.24058 0.3768 0.214493 0.168116 0.591304 0.408696 0.256522 0.343478 0.256522 0.143478 0.6 0.4 0.269565 0.286957 0.178261 0.265217 0.465217 0.534783 0.195652 0.5 0.208696 0.095652 0.708696 0.291304 0.640996 26242.39 -0.306987 0.28821 0.449782 0.213974 0.152838 0.524017 0.475983 0.279476 0.196507 0.082969 9.899345 9.406114 NMV_2239 2193201 CDS +2 2160353 2161150 798 validated/Curated no truA tRNA pseudouridine synthase A (tRNA-uridine isomerase I; tRNA pseudouridylate synthase I) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 5.4.99.12 TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN 2018-01-27 16:39:11 no Is involved in the formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer-RNAs. Pseudouridine is the most abundant modified nucleoside found in all cellular RNAs. 2 vladimir 0.221805 0.3672 0.241855 0.169173 0.609023 0.390977 0.191729 0.285714 0.37594 0.146617 0.661654 0.338346 0.270677 0.274436 0.199248 0.255639 0.473684 0.526316 0.203008 0.541353 0.150376 0.105263 0.691729 0.308271 0.65449 29323.28 -0.199623 0.324528 0.513208 0.203774 0.132075 0.584906 0.415094 0.233962 0.143396 0.090566 9.18499 9.856604 NMV_2240 2193202 CDS +1 2161273 2161512 240 validated/Curated no putative antitoxin 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2018-01-28 12:55:02 no Is the antitoxin of a toxin-antitoxin module. The neighbouring gene (NMV_2241) encodes the cognate toxin. 3 vladimir 0.308333 0.1792 0.266667 0.245833 0.445833 0.554167 0.325 0.1375 0.3625 0.175 0.5 0.5 0.3 0.1875 0.1875 0.325 0.375 0.625 0.3 0.2125 0.25 0.2375 0.4625 0.5375 0.518007 8813.8 0.051899 0.278481 0.455696 0.265823 0.075949 0.556962 0.443038 0.240506 0.101266 0.139241 4.813408 9.265823 NMV_2241 2193203 CDS +3 2161500 2161823 324 validated/Curated no putative toxin 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-28 12:54:58 no Is the toxin of a toxin-antitoxin module. The neighbouring gene (NMV_2240) encodes the cognate antitoxin. 1 vladimir 0.264151 0.2358 0.242138 0.257862 0.477987 0.522013 0.273585 0.226415 0.349057 0.150943 0.575472 0.424528 0.264151 0.198113 0.179245 0.358491 0.377358 0.622642 0.254717 0.283019 0.198113 0.264151 0.481132 0.518868 0.559205 11542.09 0.099048 0.238095 0.533333 0.295238 0.07619 0.590476 0.409524 0.238095 0.142857 0.095238 9.25399 9.12381 NMV_2242 2193204 CDS +3 2163420 2164502 1083 validated/Curated no porB major outer-membrane protein P.IB (protein IB; PIB; porin) 1c : Function from experimental evidences in the studied genus t : transporter 7 : Outer membrane protein 2018-01-27 16:39:51 no Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface, which may have pathogenic properties in addition to its porin activity. 1 vladimir 0.283472 0.2447 0.240997 0.23084 0.485688 0.514312 0.263158 0.144044 0.423823 0.168975 0.567867 0.432133 0.351801 0.243767 0.191136 0.213296 0.434903 0.565097 0.235457 0.34626 0.108033 0.310249 0.454294 0.545706 0.827562 38506.275 -0.468889 0.372222 0.583333 0.166667 0.116667 0.530556 0.469444 0.244444 0.15 0.094444 9.486732 9.205556 NMV_2244 2193206 CDS -3 2165208 2167109 1902 validated/Curated no thiC phosphomethylpyrimidine synthase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 4.1.99.17 PYRIMSYN1-RXN 2018-01-27 16:40:46 no Catalyses the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. 2 vladimir 0.253943 0.3186 0.25552 0.171924 0.574132 0.425867 0.263407 0.241325 0.347003 0.148265 0.588328 0.411672 0.326498 0.233438 0.190852 0.249211 0.42429 0.57571 0.171924 0.481073 0.228707 0.118297 0.709779 0.290221 0.738763 71120.08 -0.461137 0.28594 0.475513 0.194313 0.116904 0.530806 0.469194 0.293839 0.156398 0.137441 6.112129 9.796209 NMV_misc_RNA_7 2194966 misc_RNA -1 2167201 2167301 101 validated/Curated no TPP riboswitch (THI element) 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:46:48 28334889 The THI element is a highly conserved RNA secondary structure. It serves as a riboswitch that binds directly to thiamine pyrophosphate (TPP) to regulate gene expression. vladimir NMV_tRNA_32 2194847 tRNA +1 2167450 2167526 77 validated/Curated no Met tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:59:37 no tRNA Met anticodon CAT. vladimir NMV_2245 2193207 CDS +1 2167708 2168583 876 validated/Curated no putative NUDIX hydrolase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-27 16:41:12 no Belongs to the ''NUDIX hydrolases'' (NUcleoside DIphosphate linked to some other moiety X) family of proteins. 2 vladimir 0.208904 0.2831 0.297945 0.210046 0.58105 0.41895 0.202055 0.246575 0.363014 0.188356 0.609589 0.390411 0.280822 0.208904 0.239726 0.270548 0.44863 0.55137 0.143836 0.393836 0.291096 0.171233 0.684931 0.315068 0.66276 32263.14 -0.24055 0.312715 0.5189 0.206186 0.127148 0.563574 0.436426 0.261168 0.120275 0.140893 4.986977 9.261168 NMV_2246 2193208 CDS +3 2168592 2169530 939 validated/Curated no putative ABC transporter ATP-binding protein 3 : Putative function from multiple computational evidences t : transporter 1 : Unknown 3.6.3.- 2008-04-15 16:02:08 no 2 vladimir 0.222577 0.2854 0.28754 0.204473 0.57295 0.42705 0.230032 0.277955 0.351438 0.140575 0.629393 0.370607 0.268371 0.220447 0.207668 0.303514 0.428115 0.571885 0.169329 0.357827 0.303514 0.169329 0.661342 0.338658 0.61929 34525.685 -0.195192 0.282051 0.474359 0.237179 0.070513 0.554487 0.445513 0.291667 0.163462 0.128205 7.297203 9.919872 NMV_2247 2193209 CDS -1 2170805 2172580 1776 validated/Curated no ptsI PTS system EI component 2a : Function from experimental evidences in other organisms t : transporter 2 : Cytoplasmic 4.4.A : Phosphotransferase Systems (PEP-dependent PTS) ; 4.8.A.7 : The Phosphotransferase System Enzyme I (EI) Family ; 2.7.3.9 2.7.3.9-RXN 2020-02-26 12:09:32 no Is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase systems (PTS). The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I (EI). Phospho-HPr then transfers it to the permease known as enzyme 2 (EII), which transports the sugar into the cell. 2 vladimir 0.237613 0.2979 0.280968 0.183559 0.578829 0.421171 0.280405 0.226351 0.380068 0.113176 0.606419 0.393581 0.3125 0.202703 0.177365 0.307432 0.380068 0.619932 0.119932 0.464527 0.285473 0.130068 0.75 0.25 0.690428 65152.14 -0.163959 0.274112 0.500846 0.250423 0.069374 0.539763 0.460237 0.28088 0.142132 0.138748 5.721947 9.610829 NMV_2248 2193210 CDS -2 2172580 2172849 270 validated/Curated no ptsH PTS system carrier protein HPr component (phosphocarrier protein HPr) 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 4.4.A : Phosphotransferase Systems (PEP-dependent PTS) ; 4.8.A.8 : The Phosphotransferase System HPr (HPr) Family ; 2020-02-26 12:11:11 no Is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase systems (PTS). The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I (EI). Phospho-HPr then transfers it to the permease known as enzyme 2 (EII), which transports the sugar into the cell. 1 vladimir 0.277778 0.2963 0.274074 0.151852 0.57037 0.42963 0.344444 0.166667 0.377778 0.111111 0.544444 0.455556 0.311111 0.211111 0.188889 0.288889 0.4 0.6 0.177778 0.511111 0.255556 0.055556 0.766667 0.233333 0.672674 9607.56 -0.135955 0.359551 0.483146 0.202247 0.067416 0.52809 0.47191 0.235955 0.11236 0.123596 5.296516 9.146067 NMV_2249 2193211 CDS -3 2172918 2173355 438 validated/Curated no ptsL PTS system EIIA component 2b : Function from indirect experimental evidences (e.g. phenotypes) t : transporter 1 : Unknown 4.4.A : Phosphotransferase Systems (PEP-dependent PTS) ; 2.7.1.- 2020-02-26 12:15:45 no Is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase systems (PTS). The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I (EI). Phospho-HPr then transfers it to the permease known as enzyme 2 (EII), which transports the sugar into the cell. 2 vladimir 0.232877 0.3014 0.27169 0.194064 0.573059 0.426941 0.260274 0.212329 0.40411 0.123288 0.616438 0.383562 0.267123 0.267123 0.157534 0.308219 0.424658 0.575342 0.171233 0.424658 0.253425 0.150685 0.678082 0.321918 0.61924 15619.32 0.135172 0.310345 0.544828 0.241379 0.075862 0.606897 0.393103 0.234483 0.103448 0.131034 4.839256 9.882759 NMV_2250 2193212 CDS -3 2173437 2174000 564 validated/Curated no hpt hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT; HGXPRTase; HGPRT) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.4.2.8 GUANPRIBOSYLTRAN-RXN$HYPOXANPRIBOSYLTRAN-RXN P1-PWY$PWY-6599$PWY-6620 2018-01-27 16:42:48 no Catalyses the following reaction: IMP + diphosphate <=> hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. 1 vladimir 0.219858 0.2429 0.308511 0.228723 0.551418 0.448582 0.196809 0.234043 0.404255 0.164894 0.638298 0.361702 0.31383 0.18617 0.191489 0.308511 0.37766 0.62234 0.148936 0.308511 0.329787 0.212766 0.638298 0.361702 0.661476 20762.12 -0.113369 0.262032 0.491979 0.235294 0.101604 0.614973 0.385027 0.272727 0.13369 0.139037 5.403221 9.839572 NMV_2251 2193213 CDS -1 2174069 2174893 825 validated/Curated no putative DNA ligase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 6.5.1.1 DNA-LIGASE-ATP-RXN$DNA-LIGASE-NAD+-RXN 2018-01-27 16:43:56 no Catalyses efficient strand joining on a single nicked DNA. 2 vladimir 0.247273 0.2764 0.289697 0.186667 0.566061 0.433939 0.258182 0.250909 0.327273 0.163636 0.578182 0.421818 0.298182 0.214545 0.250909 0.236364 0.465455 0.534545 0.185455 0.363636 0.290909 0.16 0.654545 0.345455 0.638234 30681.865 -0.556204 0.306569 0.481752 0.171533 0.124088 0.543796 0.456204 0.270073 0.178832 0.091241 9.997185 9.540146 NMV_2252 2193214 CDS +3 2174985 2175617 633 validated/Curated no putative hydroxyacylglutathione hydrolase GloC 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 1.7.23 : Methylglyoxal metabolism ; 3.1.2.6 GLYOXII-RXN$RXN-7919 PWY-5386 2020-02-19 14:12:20 no Type II glyoxalase that hydrolyses (R)-S-lactoylglutathione to (R)-lactate and glutathione. 2 vladimir 0.225908 0.3144 0.249605 0.210111 0.563981 0.436019 0.218009 0.293839 0.336493 0.151659 0.630332 0.369668 0.2891 0.236967 0.161137 0.312796 0.398104 0.601896 0.170616 0.412322 0.251185 0.165877 0.663507 0.336493 0.625437 23472.925 -0.078095 0.266667 0.5 0.238095 0.157143 0.585714 0.414286 0.238095 0.128571 0.109524 5.79287 9.609524 NMV_2253 2193215 CDS -1 2175824 2177608 1785 validated/Curated no putative RmuC-like protein 3 : Putative function from multiple computational evidences f : factor 9 : Periplasmic 2018-01-27 16:45:28 no Is probably involved in DNA recombination. 1 vladimir 0.262185 0.2331 0.305322 0.19944 0.538375 0.461625 0.215126 0.236975 0.388235 0.159664 0.62521 0.37479 0.379832 0.201681 0.151261 0.267227 0.352941 0.647059 0.191597 0.260504 0.376471 0.171429 0.636975 0.363025 0.605897 66735.585 -0.499832 0.267677 0.430976 0.223906 0.075758 0.479798 0.520202 0.29798 0.141414 0.156566 5.246635 9.643098 NMV_2254 2193216 CDS -2 2177947 2178732 786 validated/Curated no petC cytochrome c1 2a : Function from experimental evidences in other organisms c : carrier 6 : Inner membrane-associated 1.3.6 : Aerobic respiration ; 2018-01-31 14:26:55 no Component of the ubiquinol-cytochrome c reductase complex, which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Cytochrome c1 functions as an electron donor to cytochrome c. The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. 1 vladimir 0.268448 0.2366 0.254453 0.240458 0.491094 0.508906 0.255725 0.217557 0.339695 0.187023 0.557252 0.442748 0.354962 0.187023 0.167939 0.290076 0.354962 0.645038 0.194656 0.305344 0.255725 0.244275 0.561069 0.438931 0.773491 29731.12 -0.319157 0.241379 0.471264 0.203065 0.145594 0.582375 0.417625 0.260536 0.153257 0.10728 8.834328 9.605364 NMV_2255 2193217 CDS -3 2178747 2180096 1350 validated/Curated no petB cytochrome b 2a : Function from experimental evidences in other organisms f : factor 5 : Inner membrane protein 1.3.6 : Aerobic respiration ; 2018-01-31 14:26:36 no Component of the ubiquinol-cytochrome c reductase complex, which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. 1 vladimir 0.198519 0.2593 0.245185 0.297037 0.504444 0.495556 0.251111 0.177778 0.32 0.251111 0.497778 0.502222 0.224444 0.226667 0.148889 0.4 0.375556 0.624444 0.12 0.373333 0.266667 0.24 0.64 0.36 0.803336 50299.48 0.593764 0.260579 0.481069 0.280624 0.180401 0.706013 0.293987 0.151448 0.095768 0.055679 9.335808 8.895323 NMV_2256 2193218 CDS -3 2180115 2180696 582 validated/Curated no petA ubiquinol-cytochrome c reductase iron-sulfur subunit (Rieske iron-sulfur protein; RISP) 2a : Function from experimental evidences in other organisms e : enzyme 9 : Periplasmic 1.3.6 : Aerobic respiration ; 7.1.1.8 2020-04-21 13:19:23 no Component of the ubiquinol-cytochrome c reductase complex, which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Cytochrome c1 functions as an electron donor to cytochrome c. The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. 1 vladimir 0.226804 0.2904 0.274914 0.207904 0.565292 0.434708 0.237113 0.21134 0.386598 0.164948 0.597938 0.402062 0.293814 0.268041 0.190722 0.247423 0.458763 0.541237 0.149485 0.391753 0.247423 0.21134 0.639175 0.360825 0.717196 20631.59 -0.187047 0.336788 0.585492 0.202073 0.088083 0.590674 0.409326 0.222798 0.108808 0.11399 5.427681 9.341969 NMV_2257 2193219 CDS -1 2180819 2181568 750 validated/Curated no putative GTP cyclohydrolase 1 type 2 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-01-30 23:39:20 no 14519207 1 vladimir 0.258667 0.2267 0.293333 0.221333 0.52 0.48 0.236 0.204 0.388 0.172 0.592 0.408 0.312 0.236 0.184 0.268 0.42 0.58 0.228 0.24 0.308 0.224 0.548 0.452 0.575086 27483.09 -0.201205 0.317269 0.48996 0.212851 0.124498 0.558233 0.441767 0.261044 0.140562 0.120482 6.072182 9.706827 NMV_2258 2193220 CDS +3 2181699 2182628 930 validated/Curated no putative HTH-type transcriptional regulator MetR 3 : Putative function from multiple computational evidences r : regulator 2 : Cytoplasmic 2018-01-27 16:47:24 no Is involved in the control of the last step in methionine biosynthesis: it is a positive activator of the metA, metE and metH genes. 2 vladimir 0.239785 0.3032 0.239785 0.217204 0.543011 0.456989 0.235484 0.293548 0.329032 0.141935 0.622581 0.377419 0.283871 0.235484 0.16129 0.319355 0.396774 0.603226 0.2 0.380645 0.229032 0.190323 0.609677 0.390323 0.659287 34888.14 -0.033657 0.249191 0.446602 0.2589 0.106796 0.582524 0.417476 0.2589 0.126214 0.132686 5.342659 9.488673 NMV_2259 2193221 CDS -1 2182883 2183275 393 validated/Curated no rpsI 30S ribosomal protein S9 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 16:47:35 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.254453 0.2901 0.24173 0.21374 0.531807 0.468193 0.244275 0.229008 0.381679 0.145038 0.610687 0.389313 0.274809 0.21374 0.244275 0.267176 0.458015 0.541985 0.244275 0.427481 0.099237 0.229008 0.526718 0.473282 0.849957 14425.035 -0.466154 0.307692 0.5 0.2 0.084615 0.523077 0.476923 0.3 0.207692 0.092308 10.950478 9.8 NMV_2260 2193222 CDS -1 2183285 2183716 432 validated/Curated no rplM 50S ribosomal protein L13 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 16:47:54 no Is one of the proteins from the large ribosomal subunit. 2 vladimir 0.287037 0.2662 0.240741 0.206019 0.506944 0.493056 0.236111 0.236111 0.381944 0.145833 0.618056 0.381944 0.375 0.208333 0.159722 0.256944 0.368056 0.631944 0.25 0.354167 0.180556 0.215278 0.534722 0.465278 0.846373 16221.17 -0.563636 0.244755 0.426573 0.181818 0.13986 0.552448 0.447552 0.342657 0.223776 0.118881 9.72364 9.503497 NMV_misc_RNA_1 2194960 misc_RNA -1 2183894 2184126 233 validated/Curated no 6S RNA (SsrS) 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:19:20 10892648, 28334889 6S RNA was the first noncoding RNA to be sequenced. 6S RNA specifically associates with RNA polymerase holoenzyme containing the sigma70 specificity factor. This interaction represses expression from a sigma70-dependent promoter during stationary phase. vladimir NMV_2261 2193223 CDS -2 2184079 2184384 306 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 19:07:03 no 2 vladimir 0.294118 0.2908 0.261438 0.153595 0.552288 0.447712 0.284314 0.196078 0.431373 0.088235 0.627451 0.372549 0.343137 0.205882 0.137255 0.313726 0.343137 0.656863 0.254902 0.470588 0.215686 0.058824 0.686275 0.313726 0.703829 10908.07 -0.056436 0.287129 0.50495 0.257426 0.039604 0.544554 0.455446 0.287129 0.138614 0.148515 5.263618 9.742574 NMV_2262 2193224 CDS -1 2184395 2184724 330 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 19:06:53 no 1 vladimir 0.372727 0.2970 0.218182 0.112121 0.515152 0.484848 0.309091 0.336364 0.318182 0.036364 0.654545 0.345455 0.445455 0.136364 0.163636 0.254545 0.3 0.7 0.363636 0.418182 0.172727 0.045455 0.590909 0.409091 0.576945 12761.99 -0.915596 0.211009 0.348624 0.238532 0.045872 0.357798 0.642202 0.376147 0.192661 0.183486 6.211891 9.431193 NMV_2263 2193225 CDS -1 2184779 2185768 990 validated/Curated no gpsA glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.6.1 : Phospholipid ; 1.1.1.94 GLYC3PDEHYDROGBIOSYN-RXN PWY-5667$PWY-5981$PWY0-1319$PWY4FS-7$PWY4FS-8 2020-04-22 12:28:25 no Catalyses the following reaction: sn-glycerol 3-phosphate + NAD(P)(+) <=> glycerone phosphate + NAD(P)H. 2 vladimir 0.242424 0.2899 0.273737 0.193939 0.563636 0.436364 0.242424 0.242424 0.387879 0.127273 0.630303 0.369697 0.260606 0.227273 0.193939 0.318182 0.421212 0.578788 0.224242 0.4 0.239394 0.136364 0.639394 0.360606 0.61061 35336.43 0.109726 0.331307 0.510638 0.264438 0.06079 0.583587 0.416413 0.212766 0.109422 0.103343 6.040993 9.392097 NMV_2264 2193226 CDS -2 2185891 2188593 2703 validated/Curated no ppc phosphoenolpyruvate carboxylase (PEPCase; PEPC) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 4.1.1.31 PEPCARBOX-RXN ANARESP1-PWY$FERMENTATION-PWY$GLUCONEO-PWY$PWY-5913$PWYQT-4429 2018-01-31 15:28:05 no Catalyses the following reaction: phosphate + oxaloacetate <=> H(2)O + phosphoenolpyruvate + CO(2). 2 vladimir 0.240844 0.3200 0.251202 0.187939 0.571217 0.428783 0.234184 0.27525 0.338513 0.152053 0.613762 0.386238 0.311876 0.210877 0.18313 0.294118 0.394007 0.605993 0.176471 0.473918 0.231964 0.117647 0.705882 0.294118 0.755064 101064.815 -0.259556 0.27 0.456667 0.231111 0.096667 0.538889 0.461111 0.272222 0.141111 0.131111 6.006813 9.537778 NMV_2265 2193227 CDS +1 2188636 2189529 894 validated/Curated no putative sulfur carrier protein ThiS adenylyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2.7.7.73 RXN-9789 2020-02-26 12:37:56 no Might catalyse the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS. 2 vladimir 0.191959 0.3230 0.293126 0.191959 0.616083 0.383917 0.167315 0.252918 0.412451 0.167315 0.66537 0.33463 0.280156 0.241245 0.206226 0.272374 0.447471 0.552529 0.128405 0.474708 0.2607 0.136187 0.735409 0.264591 0.670368 27346.905 0.019922 0.347656 0.5625 0.246094 0.082031 0.59375 0.40625 0.242188 0.109375 0.132812 4.871834 9.699219 NMNmiscRNA0072 52714393 misc_RNA +1 2189653 2189750 98 validated/Curated no Bns2 RNA 1b : Function from experimental evidences in the studied species 2018-01-28 19:18:26 22984255, 28334889 Small RNA found to be blood-induced. vladimir NMV_2266 2193228 CDS -1 2190092 2190316 225 validated/Curated no putative SlyX-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 16:51:58 no Homologous to the SlyX protein, which has no known function. It is short, less than 80 amino acids, and its gene is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C terminus. 1 vladimir 0.253333 0.2533 0.306667 0.186667 0.56 0.44 0.186667 0.346667 0.333333 0.133333 0.68 0.32 0.426667 0.2 0.093333 0.28 0.293333 0.706667 0.146667 0.213333 0.493333 0.146667 0.706667 0.293333 0.595324 8631.415 -0.632432 0.162162 0.364865 0.243243 0.067568 0.486486 0.513514 0.297297 0.108108 0.189189 4.419594 10.283784 NMV_2267 2193229 CDS -1 2190317 2191705 1389 validated/Curated no putative Na+/H+ antiporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:52:08 no Belongs to the NhaC family of Na+/H+ antiporters. 1 vladimir 0.172066 0.2743 0.308135 0.2455 0.582433 0.417567 0.267819 0.207343 0.38013 0.144708 0.587473 0.412527 0.177106 0.259179 0.159827 0.403888 0.419006 0.580994 0.071274 0.356371 0.384449 0.187905 0.740821 0.259179 0.689619 48097.165 0.859524 0.339827 0.554113 0.298701 0.08658 0.727273 0.272727 0.112554 0.069264 0.04329 8.74247 9.004329 NMV_2268 2193230 CDS -3 2191791 2193062 1272 validated/Curated no prmC hemK release factor glutamine methyltransferase (protein methyltransferase HemK; protein-glutamine N-methyltransferase HemK; protein-(glutamine-N5) MTase HemK; M.StyLTHemKP) 2a : Function from experimental evidences in other organisms e : enzyme 5 : Inner membrane protein 2.1.1.297 RXN0-1241 2018-01-22 19:08:39 no Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity. 1 vladimir 0.214623 0.2178 0.319969 0.247642 0.537736 0.462264 0.207547 0.17217 0.400943 0.21934 0.573113 0.426887 0.259434 0.240566 0.193396 0.306604 0.433962 0.566038 0.176887 0.240566 0.365566 0.216981 0.606132 0.393868 0.598129 46349.39 0.046809 0.309693 0.520095 0.245863 0.111111 0.609929 0.390071 0.234043 0.122931 0.111111 6.452858 9.437352 NMV_2269 2193231 CDS -1 2193128 2194612 1485 validated/Curated no putative TldD-like peptidase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 2018-01-27 16:52:33 no Belongs to MEROPS peptidase family U62 (clan U-). 2 vladimir 0.212058 0.3105 0.302841 0.174636 0.613306 0.386694 0.237006 0.185031 0.440748 0.137214 0.62578 0.37422 0.27027 0.232848 0.237006 0.259875 0.469854 0.530146 0.128898 0.513514 0.230769 0.126819 0.744283 0.255717 0.723567 50742.145 -0.144167 0.3625 0.58125 0.216667 0.075 0.58125 0.41875 0.233333 0.11875 0.114583 5.860909 9.7875 NMV_misc_RNA_6 2194965 misc_RNA +1 2194792 2194893 102 validated/Curated no TPP riboswitch (THI element) 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 18:54:41 28334889 The THI element is a highly conserved RNA secondary structure. It serves as a riboswitch that binds directly to thiamine pyrophosphate (TPP) to regulate gene expression. vladimir NMV_2270 2193232 CDS +3 2194959 2196182 1224 validated/Curated no putative transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 16:52:44 no Belongs to the Nucleobase Cation Symporter-1 (NCS1) family of proteins, which consists of transporters for nucleobases including purines and pyrimidines. 2 vladimir 0.155229 0.2892 0.305556 0.25 0.594771 0.405229 0.205882 0.186275 0.392157 0.215686 0.578431 0.421569 0.125 0.32598 0.188725 0.360294 0.514706 0.485294 0.134804 0.355392 0.335784 0.17402 0.691176 0.308824 0.664279 42384.86 0.840049 0.427518 0.572482 0.275184 0.110565 0.695332 0.304668 0.105651 0.056511 0.04914 7.793129 8.378378 NMV_2271 2193233 CDS +2 2196179 2197279 1101 validated/Curated no putative thiamine biosynthesis oxidoreductase ThiO 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2020-02-25 20:36:02 no Is a flavin adenine dinucleotide (FAD)-containing flavoprotein, which might have amino acid oxidase activity in the biosynthesis of thiazole when cysteine gives its thiol group to be inserted into the thiazole molecule and the rest of the molecule is deaminated to give pyruvic acid and ammonia. 2 vladimir 0.22525 0.3415 0.266122 0.167121 0.607629 0.392371 0.207084 0.294278 0.370572 0.128065 0.66485 0.33515 0.283379 0.234332 0.226158 0.256131 0.46049 0.53951 0.185286 0.495913 0.201635 0.117166 0.697548 0.302452 0.642113 40778.915 -0.305464 0.295082 0.47541 0.221311 0.103825 0.568306 0.431694 0.278689 0.153005 0.125683 6.534889 10.095628 NMV_2272 2193234 CDS +1 2197300 2197917 618 validated/Curated no thiE thiamine-phosphate synthase (thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2.5.1.3 RXN-12611$THI-P-SYN-RXN PWY-6894 2020-04-21 16:59:10 no Catalyses the substitution of the pyrophosphate of 2-methyl-4-amino-5-hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway. 2 vladimir 0.203883 0.3414 0.279935 0.174757 0.621359 0.378641 0.203883 0.218447 0.436893 0.140777 0.65534 0.34466 0.252427 0.300971 0.179612 0.26699 0.480583 0.519417 0.15534 0.504854 0.223301 0.116505 0.728155 0.271845 0.705123 21575.85 0.146341 0.380488 0.585366 0.22439 0.087805 0.619512 0.380488 0.214634 0.117073 0.097561 6.316994 9.458537 NMV_2273 2193235 CDS +2 2198339 2198533 195 validated/Curated no thiS sulfur carrier protein ThiS 2a : Function from experimental evidences in other organisms c : carrier 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2020-02-24 19:31:17 no Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. 2 vladimir 0.251282 0.3128 0.261538 0.174359 0.574359 0.425641 0.292308 0.169231 0.446154 0.092308 0.615385 0.384615 0.292308 0.261538 0.123077 0.323077 0.384615 0.615385 0.169231 0.507692 0.215385 0.107692 0.723077 0.276923 0.614685 6642.325 0.26875 0.296875 0.640625 0.28125 0.0625 0.640625 0.359375 0.171875 0.078125 0.09375 4.952797 9.46875 NMV_2274 2193236 CDS +2 2198747 2199535 789 validated/Curated no thiG thiazole synthase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 1.5.3.8 : Thiamine (Vitamin B1) ; 2.8.1.10 THIAZOLSYN2-RXN 2018-01-27 16:55:02 no Catalyses the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S. 2 vladimir 0.198986 0.3042 0.304182 0.192649 0.608365 0.391635 0.178707 0.262357 0.403042 0.155894 0.665399 0.334601 0.231939 0.288973 0.190114 0.288973 0.479087 0.520913 0.186312 0.361217 0.319392 0.13308 0.680608 0.319392 0.650939 28092.075 0.116031 0.343511 0.545802 0.232824 0.083969 0.625954 0.374046 0.194656 0.080153 0.114504 4.658638 9.564885 NMNmisc_RNA2200120D 19685345 misc_RNA +1 2200122 2200279 158 validated/Curated no nrrF NrrF 1b : Function from experimental evidences in the studied species n : RNA 2 : Cytoplasmic 2018-01-28 17:15:47 17351036, 28334889 NrrF is a non-coding RNA which is regulated by the Ferric uptake regulator (Fur) protein in bacteria. This non-coding RNA is involved in iron regulation of the succinate dehydrogenase genes sdhA and sdhC. vladimir NMV_2276 2193238 CDS -1 2200298 2201122 825 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-04-14 18:57:13 no 1 vladimir 0.260606 0.2873 0.294545 0.157576 0.581818 0.418182 0.243636 0.196364 0.436364 0.123636 0.632727 0.367273 0.338182 0.276364 0.163636 0.221818 0.44 0.56 0.2 0.389091 0.283636 0.127273 0.672727 0.327273 0.626903 29450.085 -0.433212 0.343066 0.532847 0.186131 0.062044 0.521898 0.478102 0.29562 0.156934 0.138686 7.886803 9.430657 NMV_2277 2193239 CDS -3 2201235 2203013 1779 validated/Curated no birA/coaX bifunctional enzyme BirA/CoaX [includes biotin-[acetyl-CoA-carboxylase] synthetase (biotin-protein ligase) and type III pantothenate kinase (PanK-III, pantothenic acid kinase)] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.1 : Biotin ; 1.5.3.5 : Coenzyme A ; 1.5.3.23 : Pantothenate biosynthesis I ; 6.3.4.15, 2.7.1.33 1.1.1.39-RXN$BIOTINLIG-RXN$PANTOTHENATE-KIN-RXN PANTO-PWY$PWY0-1264 2018-02-01 16:09:25 no Is homologous to two different proteins. In its N-terminal part, it is similar to the BirA enzyme that catalyses the following reaction: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] <=> AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. In its C-terminal part, it is similar to the CoaX enzyme that catalyses the following reaction: ATP + (R)-pantothenate <=> ADP + (R)-4. 1 vladimir 0.197302 0.2653 0.340079 0.197302 0.605396 0.394604 0.197302 0.237774 0.404722 0.160202 0.642496 0.357504 0.269814 0.22597 0.227656 0.27656 0.453626 0.546374 0.124789 0.332209 0.387858 0.155143 0.720067 0.279933 0.587725 64398.965 -0.178885 0.320946 0.530405 0.226351 0.094595 0.572635 0.427365 0.260135 0.150338 0.109797 8.624657 9.689189 NMV_2278 2193240 CDS -1 2203010 2203516 507 validated/Curated no rfaE2 aut D-beta-D-heptose 1-phosphate adenosyltransferase 1a : Function from experimental evidences in the studied strain e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.7.7.70 RXN0-4342 PWY0-1241 2018-01-22 20:18:05 no 12618369 Unlike in E. coli, the two domains of RfaE are genetically separated in N. meningitidis. This entry corresponds to the C-terminal domain II acting in the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-D-manno-heptose. 1 vladimir 0.171598 0.2327 0.351085 0.244576 0.583826 0.416174 0.201183 0.177515 0.426035 0.195266 0.60355 0.39645 0.218935 0.307692 0.189349 0.284024 0.497041 0.502959 0.094675 0.213018 0.43787 0.254438 0.650888 0.349112 0.632324 17753.755 0.13869 0.357143 0.577381 0.238095 0.077381 0.625 0.375 0.232143 0.125 0.107143 7.023872 9.184524 NMV_tRNA_35 2194850 tRNA -1 2203652 2203727 76 validated/Curated no His tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 16:59:53 no tRNA His anticodon GTG. vladimir NMV_tRNA_34 2194849 tRNA -1 2203755 2203831 77 validated/Curated no Arg tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:00:02 no tRNA Arg anticodon TCT. vladimir NMV_tRNA_33 2194848 tRNA -1 2203856 2203933 78 validated/Curated no Pro tRNA 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2018-01-28 17:00:12 no tRNA Pro anticodon TGG. vladimir NMV_2280 2193242 CDS +2 2204156 2205010 855 validated/Curated no folD FolD bifunctional protein (PPDC) [includes: methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase] 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 1.7.17 : Formyl-tetrahydrofolate biosynthesis ; 1.5.1.5, 3.5.4.9 METHENYLTHFCYCLOHYDRO-RXN$METHYLENETHFDEHYDROG-NADP-RXN 1CMET2-PWY$PWY-1722$PWY-2201$PWY-6613 2018-01-29 18:19:45 no Catalyses the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. 1 vladimir 0.226901 0.2690 0.308772 0.195322 0.577778 0.422222 0.22807 0.235088 0.421053 0.115789 0.65614 0.34386 0.284211 0.249123 0.161404 0.305263 0.410526 0.589474 0.168421 0.322807 0.34386 0.164912 0.666667 0.333333 0.685953 30092.465 0.075 0.306338 0.573944 0.271127 0.049296 0.59507 0.40493 0.235915 0.116197 0.119718 5.42672 9.383803 NMV_2281 2193243 CDS -1 2205071 2205652 582 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 5 : Inner membrane protein 2018-01-27 16:57:01 no Contains a domain with three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD domain. The molecular function of this region is unknown. However it may be involved in transport of an as yet unknown set of ligands. 1 vladimir 0.226804 0.2337 0.280069 0.25945 0.513746 0.486254 0.268041 0.164948 0.402062 0.164948 0.56701 0.43299 0.242268 0.175258 0.180412 0.402062 0.35567 0.64433 0.170103 0.360825 0.257732 0.21134 0.618557 0.381443 0.618401 21005.79 0.535233 0.274611 0.497409 0.326425 0.088083 0.658031 0.341969 0.196891 0.098446 0.098446 6.545464 9.098446 NMV_2282 2193244 CDS +1 2205982 2207097 1116 validated/Curated no asd aspartate-semialdehyde dehydrogenase (ASA dehydrogenase; ASADH) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.7 : Lysine, diaminopimelate ; 1.2.1.11 ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN DAPLYSINESYN-PWY$HOMOSERSYN-PWY 2018-01-27 16:57:19 no Catalyses the following reaction: L-aspartate 4-semialdehyde + phosphate + NADP(+) <=> L-4-aspartyl phosphate + NADPH. 1 vladimir 0.232079 0.2921 0.27957 0.196237 0.571685 0.428315 0.266129 0.180108 0.408602 0.145161 0.58871 0.41129 0.276882 0.204301 0.212366 0.306452 0.416667 0.583333 0.153226 0.491935 0.217742 0.137097 0.709677 0.290323 0.81348 39899.95 0.000539 0.315364 0.557951 0.242588 0.078167 0.592992 0.407008 0.226415 0.107817 0.118598 5.188637 9.293801 NMV_2283 2193245 CDS -2 2207326 2207856 531 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:53:31 no 1 vladimir 0.20339 0.2542 0.327684 0.214689 0.581921 0.418079 0.180791 0.254237 0.38983 0.175141 0.644068 0.355932 0.265537 0.220339 0.225989 0.288136 0.446328 0.553672 0.163842 0.288136 0.367232 0.180791 0.655367 0.344633 0.647672 19695.845 -0.034659 0.289773 0.471591 0.221591 0.125 0.625 0.375 0.227273 0.113636 0.113636 5.49305 9.721591 NMV_2284 2193246 CDS -2 2207866 2208210 345 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-04-14 18:53:18 no 1 vladimir 0.17971 0.2348 0.318841 0.266667 0.553623 0.446377 0.226087 0.252174 0.295652 0.226087 0.547826 0.452174 0.156522 0.234783 0.2 0.408696 0.434783 0.565217 0.156522 0.217391 0.46087 0.165217 0.678261 0.321739 0.581557 12568.865 1.035965 0.289474 0.482456 0.359649 0.105263 0.77193 0.22807 0.105263 0.078947 0.026316 9.559364 8.350877 NMV_2285 2193247 CDS -1 2208197 2208976 780 validated/Curated no putative DNA-(apurinic or apyrimidinic site) lyase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 4.2.99.18 4.2.99.18-RXN$RXN0-2601 2018-01-22 15:28:53 no The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 1 vladimir 0.260256 0.2436 0.285897 0.210256 0.529487 0.470513 0.25 0.188462 0.376923 0.184615 0.565385 0.434615 0.380769 0.169231 0.207692 0.242308 0.376923 0.623077 0.15 0.373077 0.273077 0.203846 0.646154 0.353846 0.657721 29715.4 -0.534749 0.254826 0.474903 0.181467 0.15444 0.552124 0.447876 0.297297 0.158301 0.138996 6.278008 9.957529 NMV_2286 2193248 CDS -3 2209059 2210480 1422 validated/Curated no cysS cysteine-tRNA ligase (cysteinyl-tRNA synthetase; CysRS) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.1 : Amino acid-activation ; 6.1.1.16 CYSTEINE--TRNA-LIGASE-RXN TRNA-CHARGING-PWY 2018-01-18 17:58:37 no Catalyses the attachment of cysteine to its cognate transfer RNA molecule in a highly specific two-step reaction. 2 vladimir 0.2391 0.2827 0.278481 0.199719 0.561181 0.438819 0.242616 0.21519 0.377637 0.164557 0.592827 0.407173 0.333333 0.221519 0.194093 0.251055 0.415612 0.584388 0.14135 0.411392 0.263713 0.183544 0.675105 0.324895 0.755945 52992.6 -0.44334 0.287526 0.501057 0.188161 0.128964 0.54334 0.45666 0.289641 0.147992 0.141649 5.650703 10.052854 NMV_2288 2193250 CDS -3 2210505 2211287 783 validated/Curated no putative restriction-modification system enzyme Res 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-23 19:29:30 no Contains a domain found in some restriction endonucleases, such as MvaI and BcnI. 3 vladimir 0.36143 0.1494 0.178799 0.310345 0.328225 0.671775 0.329502 0.145594 0.275862 0.249042 0.421456 0.578544 0.413793 0.191571 0.126437 0.268199 0.318008 0.681992 0.340996 0.111111 0.1341 0.413793 0.245211 0.754789 0.540512 30111.995 -0.619615 0.211538 0.426923 0.207692 0.146154 0.492308 0.507692 0.288462 0.161538 0.126923 7.285667 9.157692 NMV_2289 2193251 CDS -1 2211284 2212051 768 validated/Curated no putative restriction-modification system enzyme Mod 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2020-04-23 19:33:29 no Contains a domain is found in DNA methylases N-4/N-6. Probable role is to protect host DNA against degradation by the neighbouring restriction enzyme. 3 vladimir 0.339844 0.1471 0.203125 0.309896 0.35026 0.64974 0.339844 0.167969 0.273438 0.21875 0.441406 0.558594 0.347656 0.183594 0.183594 0.285156 0.367188 0.632812 0.332031 0.089844 0.152344 0.425781 0.242188 0.757812 0.490891 29149.47 -0.4 0.239216 0.443137 0.211765 0.129412 0.54902 0.45098 0.266667 0.156863 0.109804 9.013344 9.32549 NMV_2290 2193252 CDS -3 2212110 2212361 252 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:52:06 no 3 vladimir 0.361111 0.1865 0.214286 0.238095 0.400794 0.599206 0.345238 0.22619 0.285714 0.142857 0.511905 0.488095 0.416667 0.142857 0.154762 0.285714 0.297619 0.702381 0.321429 0.190476 0.202381 0.285714 0.392857 0.607143 0.576591 9676.89 -0.592771 0.192771 0.39759 0.253012 0.108434 0.481928 0.518072 0.313253 0.228916 0.084337 10.115532 9.216867 NMV_2291 2193253 CDS -2 2212432 2213586 1155 validated/Curated no obgE GTPase ObgE 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 6.6 : Ribosome ; 3.6.5.- RXN0-5462 2020-04-22 13:22:15 no An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of ribosome biogenesis, the cell cycle and stress response. 2 vladimir 0.270996 0.3307 0.245887 0.152381 0.576623 0.423377 0.231169 0.231169 0.420779 0.116883 0.651948 0.348052 0.348052 0.223377 0.176623 0.251948 0.4 0.6 0.233766 0.537662 0.14026 0.088312 0.677922 0.322078 0.759412 41953.665 -0.45599 0.294271 0.5 0.200521 0.09375 0.541667 0.458333 0.302083 0.148438 0.153646 5.436546 9.549479 NMV_2293 2193255 CDS +2 2214095 2214499 405 validated/Curated partial truncated putative cytochrome b561 (missing the N-terminal 30% of the protein) 5 : Unknown function m : membrane component 5 : Inner membrane protein 2018-01-27 16:59:31 no Is an integral membrane and electron transport protein that binds two heme groups non-covalently. 2 vladimir 0.177778 0.2790 0.320988 0.222222 0.6 0.4 0.22963 0.244444 0.385185 0.140741 0.62963 0.37037 0.2 0.17037 0.251852 0.377778 0.422222 0.577778 0.103704 0.422222 0.325926 0.148148 0.748148 0.251852 0.705033 14582.645 0.417164 0.298507 0.507463 0.291045 0.126866 0.671642 0.328358 0.186567 0.149254 0.037313 11.000145 9.365672 NMV_2294 2193256 CDS -3 2214534 2215409 876 validated/Curated no rsmI ribosomal RNA small subunit methyltransferase I 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.198 RXN-11637 2018-01-30 15:52:45 no 19965768 Catalyses the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. 1 vladimir 0.22831 0.2534 0.309361 0.208904 0.562785 0.437215 0.239726 0.191781 0.414384 0.15411 0.606164 0.393836 0.270548 0.256849 0.167808 0.304795 0.424658 0.575342 0.174658 0.311644 0.34589 0.167808 0.657534 0.342466 0.628975 31380.03 0.04811 0.32646 0.525773 0.237113 0.079038 0.587629 0.412371 0.24055 0.130584 0.109966 8.445213 9.271478 NMV_2295 2193257 CDS +3 2215455 2215802 348 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:50:48 no 1 vladimir 0.281609 0.2701 0.247126 0.201149 0.517241 0.482759 0.25 0.275862 0.301724 0.172414 0.577586 0.422414 0.336207 0.163793 0.224138 0.275862 0.387931 0.612069 0.258621 0.37069 0.215517 0.155172 0.586207 0.413793 0.608467 13007.44 -0.311304 0.26087 0.443478 0.234783 0.104348 0.565217 0.434783 0.226087 0.13913 0.086957 9.126244 9.886957 NMV_2296 2193258 CDS +1 2215807 2216400 594 validated/Curated no diaA DnaA initiator-associating protein DiaA 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.1.1 : DNA replication ; 2018-01-18 19:32:24 no 15326179 Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. 2 vladimir 0.240741 0.3434 0.255892 0.159933 0.599327 0.400673 0.247475 0.227273 0.429293 0.09596 0.656566 0.343434 0.292929 0.252525 0.156566 0.29798 0.409091 0.590909 0.181818 0.550505 0.181818 0.085859 0.732323 0.267677 0.731176 21060.24 0.060406 0.345178 0.532995 0.233503 0.071066 0.563452 0.436548 0.263959 0.13198 0.13198 5.434731 9.766497 NMV_2297 2193259 CDS +1 2216464 2217072 609 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2018-01-27 17:00:09 no Is one of the antigens in the Bexsero vaccine (GNA2091) that induces cross-reactive bactericidal antibodies against a number of N. meningitidis strains. 2 vladimir 0.249589 0.3678 0.228243 0.154351 0.596059 0.403941 0.305419 0.231527 0.35468 0.108374 0.586207 0.413793 0.270936 0.280788 0.182266 0.26601 0.463054 0.536946 0.172414 0.591133 0.147783 0.08867 0.738916 0.261084 0.757666 21744.985 -0.073267 0.366337 0.569307 0.242574 0.069307 0.539604 0.460396 0.173267 0.113861 0.059406 9.810051 9.608911 NMV_2298 2193260 CDS +2 2217080 2217730 651 validated/Curated no conserved hypothetical membrane-associated protein 4 : Unknown function but conserved in other organisms u : unknown 6 : Inner membrane-associated 2015-11-19 16:32:25 no 2 vladimir 0.338384 0.3788 0.191919 0.090909 0.570707 0.429293 0.318182 0.318182 0.30303 0.060606 0.621212 0.378788 0.363636 0.353535 0.121212 0.161616 0.474747 0.525253 0.333333 0.464646 0.151515 0.050505 0.616162 0.383838 0.634426 21426.27 -1.042132 0.279188 0.568528 0.137056 0.055838 0.461929 0.538071 0.294416 0.162437 0.13198 7.197975 9.284264 NMV_2299 2193261 CDS +2 2217770 2218549 780 validated/Curated no map methionine aminopeptidase (MAP; peptidase M) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.3.3 : Posttranslational modification ; 3.4.11.18 3.4.11.18-RXN 2020-02-19 14:12:57 no Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolysed. 2 vladimir 0.265385 0.3500 0.225641 0.158974 0.575641 0.424359 0.265385 0.226923 0.373077 0.134615 0.6 0.4 0.334615 0.207692 0.176923 0.280769 0.384615 0.615385 0.196154 0.615385 0.126923 0.061538 0.742308 0.257692 0.754142 28245.17 -0.22278 0.281853 0.525097 0.23166 0.111969 0.579151 0.420849 0.254826 0.138996 0.11583 6.128471 9.498069 NMV_2300 2193262 CDS +3 2218704 2219003 300 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:49:11 no 2 vladimir 0.353333 0.2500 0.216667 0.18 0.466667 0.533333 0.35 0.21 0.3 0.14 0.51 0.49 0.42 0.16 0.15 0.27 0.31 0.69 0.29 0.38 0.2 0.13 0.58 0.42 0.652729 11417.91 -0.735354 0.212121 0.383838 0.222222 0.080808 0.454545 0.545455 0.383838 0.252525 0.131313 9.813469 8.757576 NMV_2302 2193264 CDS +3 2219241 2219615 375 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:48:59 no 2 vladimir 0.296 0.2880 0.208 0.208 0.496 0.504 0.36 0.152 0.328 0.16 0.48 0.52 0.32 0.264 0.152 0.264 0.416 0.584 0.208 0.448 0.144 0.2 0.592 0.408 0.789222 13287.795 -0.182258 0.354839 0.58871 0.201613 0.072581 0.548387 0.451613 0.185484 0.129032 0.056452 9.698112 9.120968 NMV_2303 2193265 CDS -2 2219803 2221269 1467 validated/Curated no mqo malate:quinone oxidoreductase (malate dehydrogenase [acceptor]; MQO) 2a : Function from experimental evidences in other organisms e : enzyme 6 : Inner membrane-associated 1.3.4 : Tricarboxylic acid cycle ; 1.3.6 : Aerobic respiration ; 1.1.5.4 MALATE-DEHYDROGENASE-ACCEPTOR-RXN$RXNI-3 TCA 2018-01-31 15:43:33 no Catalyses the last reaction in the TCA cycle: malate + acceptor <=> oxaloacetate + reduced acceptor. It replaces the usual NAD-dependent malate dehydrogenase, which is missing in N. meningitidis. 2 vladimir 0.234492 0.2965 0.269939 0.199046 0.566462 0.433538 0.231084 0.235174 0.359918 0.173824 0.595092 0.404908 0.314928 0.239264 0.169734 0.276074 0.408998 0.591002 0.157464 0.415133 0.280164 0.147239 0.695296 0.304703 0.714743 53966.235 -0.30123 0.290984 0.5 0.204918 0.106557 0.561475 0.438525 0.252049 0.125 0.127049 5.507683 9.581967 NMV_2304 2193266 CDS -3 2221806 2222396 591 validated/Curated no putative acetyltransferase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 2018-03-20 14:48:00 no 1 vladimir 0.211506 0.2030 0.34687 0.238579 0.549915 0.450085 0.218274 0.19797 0.395939 0.187817 0.593909 0.406091 0.243655 0.208122 0.248731 0.299492 0.456853 0.543147 0.172589 0.203046 0.395939 0.228426 0.598985 0.401015 0.527379 21979.565 -0.020408 0.30102 0.510204 0.255102 0.102041 0.591837 0.408163 0.280612 0.153061 0.127551 7.092018 10.438776 NMV_2305 2193267 CDS -3 2222457 2223038 582 validated/Curated no putative 5-formyltetrahydrofolate cyclo-ligase (methenyl-THF synthetase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.2 : Folic acid ; 6.3.3.2 5-FORMYL-THF-CYCLO-LIGASE-RXN PWY-2201 2018-01-27 17:02:21 no Catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate. 1 vladimir 0.206186 0.2440 0.347079 0.202749 0.591065 0.408935 0.190722 0.283505 0.350515 0.175258 0.634021 0.365979 0.262887 0.180412 0.278351 0.278351 0.458763 0.541237 0.164948 0.268041 0.412371 0.154639 0.680412 0.319588 0.543983 22110.07 -0.407772 0.259067 0.419689 0.217617 0.11399 0.595855 0.404145 0.305699 0.217617 0.088083 10.708443 10.502591 NMV_2306 2193268 CDS +2 2223116 2223349 234 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-14 18:47:40 no 2 vladimir 0.205128 0.2949 0.264957 0.235043 0.559829 0.440171 0.24359 0.282051 0.294872 0.179487 0.576923 0.423077 0.24359 0.230769 0.179487 0.346154 0.410256 0.589744 0.128205 0.371795 0.320513 0.179487 0.692308 0.307692 0.679172 8995.21 0.087013 0.246753 0.415584 0.233766 0.155844 0.584416 0.415584 0.194805 0.142857 0.051948 10.867699 9.818182 NMV_2307 2193269 CDS +1 2223526 2224254 729 validated/Curated no rpsB 30S ribosomal protein S2 2a : Function from experimental evidences in other organisms s : structure 2 : Cytoplasmic 2.3.8 : Ribosomal proteins ; 2018-01-27 17:02:41 no Is one of the proteins from the small ribosomal subunit. 2 vladimir 0.294925 0.2743 0.23594 0.194787 0.510288 0.489712 0.296296 0.193416 0.386831 0.123457 0.580247 0.419753 0.341564 0.209877 0.164609 0.283951 0.374486 0.625514 0.246914 0.419753 0.156379 0.176955 0.576132 0.423868 0.90447 26897.875 -0.31405 0.27686 0.471074 0.214876 0.078512 0.541322 0.458678 0.27686 0.152893 0.123967 9.046349 9.801653 NMV_2308 2193270 CDS +3 2224383 2225237 855 validated/Curated no tsf elongation factor Ts (EF-Ts) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-03-20 14:46:29 no Is a component of the elongation cycle of protein biosynthesis. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. 2 vladimir 0.288889 0.2526 0.25848 0.2 0.511111 0.488889 0.25614 0.115789 0.515789 0.112281 0.631579 0.368421 0.329825 0.252632 0.133333 0.284211 0.385965 0.614035 0.280702 0.389474 0.126316 0.203509 0.515789 0.484211 0.889871 30269.435 0.020423 0.334507 0.535211 0.221831 0.066901 0.584507 0.415493 0.285211 0.133803 0.151408 5.212456 9.866197 NMV_2309 2193271 CDS +3 2225562 2226281 720 validated/Curated no pyrH uridylate kinase (UK; uridine monophosphate kinase; UMP kinase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism ; 2.7.4.22 2.7.4.22-RXN P1-PWY$PWY-5687 2018-01-31 21:12:07 no Converts UMP to UDP by adding a phosphate from ATP. 2 vladimir 0.266667 0.2806 0.245833 0.206944 0.526389 0.473611 0.291667 0.15 0.4125 0.145833 0.5625 0.4375 0.283333 0.25 0.154167 0.3125 0.404167 0.595833 0.225 0.441667 0.170833 0.1625 0.6125 0.3875 0.774576 25673.61 0.072385 0.343096 0.543933 0.225941 0.07113 0.577406 0.422594 0.225941 0.117155 0.108787 6.937675 9.665272 NMV_2310 2193272 CDS +3 2226465 2227427 963 validated/Curated no mafA3 MafA3 lipoprotein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 8 : Outer membrane-associated 2008-04-14 18:46:14 no 3 vladimir 0.293873 0.2409 0.227414 0.237799 0.468328 0.531672 0.29595 0.183801 0.336449 0.183801 0.520249 0.479751 0.286604 0.264798 0.196262 0.252336 0.461059 0.538941 0.299065 0.274143 0.149533 0.277259 0.423676 0.576324 0.545245 34878.895 -0.33 0.353125 0.553125 0.196875 0.10625 0.525 0.475 0.225 0.125 0.1 8.230415 9.5 NMV_2312 2193274 CDS +3 2227467 2228912 1446 validated/Curated no mafB3 MafB3 toxin 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 10 : Secreted 2015-11-13 15:54:43 no 25569427 3 vladimir 0.302905 0.2254 0.235823 0.235823 0.461272 0.538728 0.290456 0.207469 0.358921 0.143154 0.56639 0.43361 0.317427 0.275934 0.195021 0.211618 0.470954 0.529046 0.30083 0.192946 0.153527 0.352697 0.346473 0.653527 0.543613 51788.48 -0.508524 0.343035 0.592516 0.162162 0.12474 0.538462 0.461538 0.230769 0.133056 0.097713 6.729286 9.282744 NMV_2313 2193275 CDS +1 2228878 2229261 384 validated/Curated no mafI3 MafB3 immunity protein 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2015-11-13 15:55:21 no 25569427 3 vladimir 0.40625 0.1120 0.132812 0.348958 0.244792 0.755208 0.414062 0.125 0.21875 0.242188 0.34375 0.65625 0.453125 0.117188 0.085938 0.34375 0.203125 0.796875 0.351562 0.09375 0.09375 0.460938 0.1875 0.8125 0.471796 14976.77 -0.277953 0.149606 0.393701 0.283465 0.141732 0.511811 0.488189 0.275591 0.149606 0.125984 7.008492 8.669291 NMV_2314 2193276 CDS +1 2229550 2230194 645 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:03:24 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.361111 0.1821 0.222222 0.234568 0.404321 0.595679 0.37037 0.162037 0.333333 0.134259 0.49537 0.50463 0.337963 0.287037 0.194444 0.180556 0.481481 0.518519 0.375 0.097222 0.138889 0.388889 0.236111 0.763889 0.449885 23233.99 -0.667907 0.362791 0.567442 0.153488 0.083721 0.497674 0.502326 0.223256 0.134884 0.088372 9.571648 9.218605 NMV_2315 2193277 CDS +2 2230199 2230558 360 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:34:31 no 25569427 3 vladimir 0.383333 0.1056 0.144444 0.366667 0.25 0.75 0.341667 0.083333 0.225 0.35 0.308333 0.691667 0.433333 0.141667 0.1 0.325 0.241667 0.758333 0.375 0.091667 0.108333 0.425 0.2 0.8 0.457256 14142.37 -0.331933 0.184874 0.428571 0.243697 0.159664 0.478992 0.521008 0.277311 0.10084 0.176471 4.340446 8.806723 NMV_2316 2193278 CDS +2 2230634 2230846 213 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:36:43 no 25569427 3 vladimir 0.375587 0.0657 0.206573 0.352113 0.2723 0.7277 0.408451 0.070423 0.295775 0.225352 0.366197 0.633803 0.380282 0.042254 0.15493 0.422535 0.197183 0.802817 0.338028 0.084507 0.169014 0.408451 0.253521 0.746479 0.435047 8141.335 0.364286 0.171429 0.357143 0.342857 0.128571 0.585714 0.414286 0.285714 0.142857 0.142857 5.708168 8.2 NMV_2317 2193279 CDS +2 2230943 2231788 846 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:03:42 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.331042 0.2039 0.232532 0.232532 0.436426 0.563574 0.33677 0.168385 0.364261 0.130584 0.532646 0.467354 0.333333 0.278351 0.182131 0.206186 0.460481 0.539519 0.323024 0.164948 0.151203 0.360825 0.316151 0.683849 0.514509 31279.445 -0.528966 0.344828 0.596552 0.168966 0.086207 0.510345 0.489655 0.227586 0.117241 0.110345 5.880348 9.344828 NMV_2318 2193280 CDS +2 2231798 2232004 207 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:36:10 no 25569427 3 vladimir 0.396135 0.1208 0.164251 0.318841 0.285024 0.714976 0.347826 0.130435 0.304348 0.217391 0.434783 0.565217 0.391304 0.173913 0.101449 0.333333 0.275362 0.724638 0.449275 0.057971 0.086957 0.405797 0.144928 0.855072 0.45892 7734.435 -0.198529 0.235294 0.485294 0.264706 0.088235 0.470588 0.529412 0.220588 0.102941 0.117647 5.120491 9.661765 NMV_2320 2193282 CDS +1 2232136 2232387 252 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:44:43 no 3 vladimir 0.384921 0.1349 0.253968 0.22619 0.388889 0.611111 0.369048 0.178571 0.333333 0.119048 0.511905 0.488095 0.369048 0.154762 0.238095 0.238095 0.392857 0.607143 0.416667 0.071429 0.190476 0.321429 0.261905 0.738095 0.421762 9663.62 -0.950602 0.216867 0.433735 0.180723 0.096386 0.445783 0.554217 0.361446 0.228916 0.13253 10.076759 9.987952 NMV_2321 2193283 CDS +3 2232384 2232755 372 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:04:02 no 25569427 SMI1 / KNR4 family (SUKH-1) 3 vladimir 0.362903 0.1452 0.16129 0.330645 0.306452 0.693548 0.322581 0.137097 0.274194 0.266129 0.41129 0.58871 0.419355 0.209677 0.112903 0.258065 0.322581 0.677419 0.346774 0.08871 0.096774 0.467742 0.185484 0.814516 0.553545 14480.65 -0.510569 0.211382 0.455285 0.170732 0.186992 0.536585 0.463415 0.227642 0.081301 0.146341 4.407417 9.365854 NMV_2322 2193284 CDS +3 2232864 2233454 591 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:04:14 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.405229 0.1536 0.215686 0.22549 0.369281 0.630719 0.401961 0.127451 0.313726 0.156863 0.441176 0.558824 0.411765 0.22549 0.147059 0.215686 0.372549 0.627451 0.401961 0.107843 0.186275 0.303922 0.294118 0.705882 0.477368 11301.34 -0.970297 0.267327 0.49505 0.158416 0.059406 0.435644 0.564356 0.306931 0.178218 0.128713 9.43589 9.336634 NMV_2323 2193285 CDS +2 2233457 2233801 345 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:39:02 no 25569427 3 vladimir 0.426087 0.0928 0.142029 0.33913 0.234783 0.765217 0.356522 0.086957 0.295652 0.26087 0.382609 0.617391 0.521739 0.095652 0.043478 0.33913 0.13913 0.86087 0.4 0.095652 0.086957 0.417391 0.182609 0.817391 0.601844 13948.185 -0.55 0.105263 0.342105 0.236842 0.157895 0.45614 0.54386 0.333333 0.105263 0.22807 4.191444 9.412281 NMV_2324 2193286 CDS +3 2233839 2234183 345 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-14 18:38:28 no 3 vladimir 0.405797 0.1536 0.127536 0.313043 0.281159 0.718841 0.426087 0.13913 0.217391 0.217391 0.356522 0.643478 0.4 0.147826 0.104348 0.347826 0.252174 0.747826 0.391304 0.173913 0.06087 0.373913 0.234783 0.765217 0.475918 13276.835 -0.207018 0.184211 0.385965 0.27193 0.140351 0.491228 0.508772 0.280702 0.157895 0.122807 6.841972 8.429825 NMV_2325 2193287 CDS +2 2234693 2235358 666 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:04:39 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.387446 0.1905 0.186147 0.235931 0.376623 0.623377 0.38961 0.162338 0.24026 0.207792 0.402597 0.597403 0.422078 0.24026 0.136364 0.201299 0.376623 0.623377 0.350649 0.168831 0.181818 0.298701 0.350649 0.649351 0.485211 17351.91 -1.022876 0.267974 0.490196 0.137255 0.117647 0.437908 0.562092 0.300654 0.189542 0.111111 9.406624 9 NMV_2326 2193288 CDS +3 2235324 2235530 207 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:41:20 no 25569427 3 vladimir 0.36715 0.1401 0.256039 0.236715 0.396135 0.603865 0.333333 0.115942 0.376812 0.173913 0.492754 0.507246 0.391304 0.188406 0.202899 0.217391 0.391304 0.608696 0.376812 0.115942 0.188406 0.318841 0.304348 0.695652 0.484958 7680.345 -0.519118 0.294118 0.514706 0.161765 0.088235 0.544118 0.455882 0.279412 0.088235 0.191176 4.248268 11.044118 NMV_2328 2193290 CDS +1 2235709 2236011 303 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-14 18:38:06 no 3 vladimir 0.372937 0.0990 0.174917 0.353135 0.273927 0.726073 0.356436 0.069307 0.267327 0.306931 0.336634 0.663366 0.386139 0.118812 0.118812 0.376238 0.237624 0.762376 0.376238 0.108911 0.138614 0.376238 0.247525 0.752475 0.434958 11695.055 0.153 0.18 0.37 0.3 0.17 0.61 0.39 0.21 0.09 0.12 4.781898 8.97 NMV_2329 2193291 CDS +3 2236098 2236706 609 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:05:00 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.349206 0.1746 0.250794 0.225397 0.425397 0.574603 0.266667 0.247619 0.342857 0.142857 0.590476 0.409524 0.380952 0.2 0.238095 0.180952 0.438095 0.561905 0.4 0.07619 0.171429 0.352381 0.247619 0.752381 0.483841 11850.695 -1.258654 0.240385 0.5 0.144231 0.086538 0.451923 0.548077 0.317308 0.182692 0.134615 9.394234 10.701923 NMV_2330 2193292 CDS +2 2236703 2237020 318 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:44:16 no 25569427 3 vladimir 0.386792 0.1101 0.144654 0.358491 0.254717 0.745283 0.424528 0.084906 0.235849 0.254717 0.320755 0.679245 0.415094 0.122642 0.09434 0.367925 0.216981 0.783019 0.320755 0.122642 0.103774 0.45283 0.226415 0.773585 0.47737 12255.52 -0.015238 0.190476 0.409524 0.266667 0.171429 0.533333 0.466667 0.238095 0.085714 0.152381 4.40197 8.428571 NMV_2331 2193293 CDS +2 2237096 2237830 735 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:05:14 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.362031 0.1700 0.245033 0.222958 0.415011 0.584989 0.430464 0.178808 0.324503 0.066225 0.503311 0.496689 0.357616 0.198675 0.251656 0.192053 0.450331 0.549669 0.298013 0.13245 0.15894 0.410596 0.291391 0.708609 0.451817 16177.135 -0.884667 0.333333 0.62 0.18 0.033333 0.42 0.58 0.246667 0.14 0.106667 9.596642 9.453333 NMV_2332 2193294 CDS +2 2237834 2238235 402 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2015-11-13 16:45:43 no 25569427 3 vladimir 0.333333 0.0995 0.186567 0.380597 0.28607 0.71393 0.320896 0.067164 0.320896 0.291045 0.38806 0.61194 0.373134 0.156716 0.11194 0.358209 0.268657 0.731343 0.30597 0.074627 0.126866 0.492537 0.201493 0.798507 0.52076 15679.23 -0.000752 0.218045 0.398496 0.225564 0.203008 0.556391 0.443609 0.278195 0.097744 0.180451 4.350594 9.030075 NMV_2333 2193295 CDS +1 2238394 2238738 345 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 1 : Unknown 2008-04-14 18:37:20 no 3 vladimir 0.391304 0.1043 0.121739 0.382609 0.226087 0.773913 0.408696 0.095652 0.165217 0.330435 0.26087 0.73913 0.426087 0.095652 0.086957 0.391304 0.182609 0.817391 0.33913 0.121739 0.113043 0.426087 0.234783 0.765217 0.452469 13929.495 -0.229825 0.140351 0.350877 0.201754 0.236842 0.517544 0.482456 0.236842 0.122807 0.114035 6.13958 8.991228 NMV_2334 2193296 CDS +1 2238772 2238876 105 validated/Curated partial putative MafB alternative C-terminus cassette 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-01-27 17:05:32 no 25569427 N-terminus shows homology to MafB whereas C-terminus is divergent. Is expected to allow antigenic variation of MafB upon recombination at the mafB gene. 3 vladimir 0.380952 0.1714 0.171429 0.27619 0.342857 0.657143 0.514286 0.142857 0.2 0.142857 0.342857 0.657143 0.4 0.085714 0.142857 0.371429 0.228571 0.771429 0.228571 0.285714 0.171429 0.314286 0.457143 0.542857 0.478808 3929.545 -0.017647 0.147059 0.382353 0.352941 0.058824 0.558824 0.441176 0.235294 0.176471 0.058824 9.994514 8.558824 NMV_2335 2193297 CDS +2 2238881 2239237 357 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2020-04-23 19:44:29 no 25569427, 23531546 Part of a Maf genomic island. Is likely to encode a specific immunity protein (MafI) protecting the host against a MafB toxin. Has been shown to be a DNA-mimic protein interacting with the histone-like protein HU, which may be instrumental in controlling the stability of the nucleoid in Neisseria. 3 vladimir 0.386555 0.1036 0.176471 0.333333 0.280112 0.719888 0.369748 0.117647 0.285714 0.226891 0.403361 0.596639 0.403361 0.134454 0.12605 0.336134 0.260504 0.739496 0.386555 0.058824 0.117647 0.436975 0.176471 0.823529 0.525715 13894.255 -0.218644 0.186441 0.398305 0.279661 0.135593 0.483051 0.516949 0.279661 0.110169 0.169492 4.607796 8.898305 NMV_2337 2193299 CDS +3 2239410 2239784 375 validated/Curated no putative MafI immunity protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-03-20 14:38:21 no 25569427 SMI1 / KNR4 family (SUKH-1). 3 vladimir 0.330667 0.1200 0.178667 0.370667 0.298667 0.701333 0.328 0.136 0.272 0.264 0.408 0.592 0.392 0.16 0.144 0.304 0.304 0.696 0.272 0.064 0.12 0.544 0.184 0.816 0.496159 14749.875 -0.355645 0.177419 0.451613 0.209677 0.201613 0.548387 0.451613 0.225806 0.072581 0.153226 4.266319 9.951613 NMV_2339 2193301 CDS -3 2239851 2240066 216 validated/Curated partial truncated IS1016 group transposase (C-terminal 38% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-05-16 11:34:54 no 3 vladimir 0.328704 0.1898 0.194444 0.287037 0.384259 0.615741 0.305556 0.236111 0.236111 0.222222 0.472222 0.527778 0.430556 0.111111 0.194444 0.263889 0.305556 0.694444 0.25 0.222222 0.152778 0.375 0.375 0.625 0.583702 8596.34 -0.816901 0.183099 0.366197 0.15493 0.239437 0.450704 0.549296 0.338028 0.225352 0.112676 8.992302 9.690141 NMV_2342 2193304 CDS -2 2240740 2241726 987 validated/Curated no putative peptidase 3 : Putative function from multiple computational evidences e : enzyme 1 : Unknown 3.4.21.- 2018-01-23 11:31:51 no Belongs to MEROPS peptidase family S49 (protease IV family, clan S-). 2 vladimir 0.258359 0.2806 0.294833 0.16616 0.575481 0.424519 0.279635 0.18845 0.413374 0.118541 0.601824 0.398176 0.297872 0.206687 0.224924 0.270517 0.431611 0.568389 0.197568 0.446809 0.246201 0.109422 0.693009 0.306991 0.65182 36003.835 -0.265244 0.29878 0.515244 0.219512 0.085366 0.57622 0.42378 0.277439 0.155488 0.121951 9.29821 9.786585 NMV_2343 2193305 CDS -2 2241766 2242566 801 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-01-27 19:11:50 no Belongs to the MoaB/Mog-like domain superfamily (IPR036425). 2 vladimir 0.23221 0.2996 0.264669 0.203496 0.564295 0.435705 0.217228 0.254682 0.355805 0.172285 0.610487 0.389513 0.318352 0.228464 0.172285 0.280899 0.400749 0.599251 0.161049 0.41573 0.265918 0.157303 0.681648 0.318352 0.676305 29744.455 -0.333835 0.266917 0.484962 0.199248 0.139098 0.552632 0.447368 0.266917 0.131579 0.135338 5.354515 9.492481 NMV_2344 2193306 CDS +2 2243030 2244373 1344 validated/Curated no argG argininosuccinate synthase (citrulline-aspartate ligase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.1.3 : Arginine ; 6.3.4.5 ARGSUCCINSYN-RXN ARGSYN-PWY$ARGSYNBSUB-PWY 2018-03-20 14:37:01 no Is an enzyme from the urea cycle that catalyses the penultimate step in arginine biosynthesis: ATP + L-citrulline + L-aspartate <=> AMP + diphosphate + (N(omega)-L-arginino)succinate. 2 vladimir 0.264881 0.3125 0.239583 0.183036 0.552083 0.447917 0.272321 0.212054 0.352679 0.162946 0.564732 0.435268 0.334821 0.203125 0.183036 0.279018 0.386161 0.613839 0.1875 0.522321 0.183036 0.107143 0.705357 0.294643 0.767013 49803.51 -0.314765 0.284116 0.47651 0.217002 0.105145 0.552573 0.447427 0.246085 0.116331 0.129754 5.180305 9.774049 NMV_2345 2193307 CDS +1 2244448 2244663 216 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:36:05 no 1 vladimir 0.25463 0.2361 0.25463 0.25463 0.490741 0.509259 0.263889 0.194444 0.319444 0.222222 0.513889 0.486111 0.319444 0.125 0.166667 0.388889 0.291667 0.708333 0.180556 0.388889 0.277778 0.152778 0.666667 0.333333 0.706024 8446.65 -0.033803 0.169014 0.394366 0.267606 0.140845 0.56338 0.43662 0.28169 0.169014 0.112676 9.693733 9.549296 NMV_2346 2193308 CDS +2 2244656 2244871 216 validated/Curated no hypothetical integral membrane protein 5 : Unknown function u : unknown 11 : Membrane 2008-04-14 18:35:47 no 1 vladimir 0.189815 0.2269 0.259259 0.324074 0.486111 0.513889 0.208333 0.208333 0.319444 0.263889 0.527778 0.472222 0.208333 0.138889 0.152778 0.5 0.291667 0.708333 0.152778 0.333333 0.305556 0.208333 0.638889 0.361111 0.59243 8028.45 1.24507 0.253521 0.380282 0.352113 0.183099 0.760563 0.239437 0.140845 0.070423 0.070423 6.262413 7.774648 NMV_2347 2193309 CDS -1 2244947 2246482 1536 validated/Curated no neisserial heparin-binding antigen (NHBA) 1b : Function from experimental evidences in the studied species ph : phenotype 11 : Membrane 2018-01-27 17:07:30 no 14639545, 20133713 Is one of the antigens in the Bexsero vaccine (GNA2132) that induces cross-reactive bactericidal antibodies against a number of N. meningitidis strains. The protein binds heparin. 1 vladimir 0.283702 0.2294 0.300469 0.186452 0.529846 0.470154 0.277666 0.146881 0.444668 0.130785 0.591549 0.408451 0.350101 0.289738 0.193159 0.167002 0.482897 0.517103 0.22334 0.251509 0.263581 0.261569 0.515091 0.484909 0.574427 51341.495 -0.745161 0.387097 0.655242 0.116935 0.066532 0.514113 0.485887 0.25 0.104839 0.145161 4.650841 9.739919 NMV_2348 2193310 CDS -1 2246549 2247778 1230 validated/Curated no sstT Serine/threonine transporter SstT 2a : Function from experimental evidences in other organisms t : transporter 5 : Inner membrane protein 2018-03-20 14:36:01 no 12097162 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). 1 vladimir 0.156098 0.2707 0.317073 0.256098 0.587805 0.412195 0.239024 0.163415 0.407317 0.190244 0.570732 0.429268 0.158537 0.302439 0.160976 0.378049 0.463415 0.536585 0.070732 0.346341 0.382927 0.2 0.729268 0.270732 0.68825 41926.7 0.942543 0.388753 0.586797 0.315403 0.085575 0.711491 0.288509 0.112469 0.07335 0.03912 9.389427 8.533007 NMV_2349 2193311 CDS +3 2248188 2250035 1848 validated/Curated no putative translocation and assembly module TamA 3 : Putative function from multiple computational evidences t : transporter 7 : Outer membrane protein 2018-01-31 10:41:38 no 22466966 Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. 2 vladimir 0.240801 0.3317 0.250541 0.176948 0.582251 0.417749 0.25974 0.238636 0.345779 0.155844 0.584416 0.415584 0.308442 0.233766 0.196429 0.261364 0.430195 0.569805 0.154221 0.522727 0.209416 0.113636 0.732143 0.267857 0.675505 67847.85 -0.369593 0.313821 0.528455 0.198374 0.121951 0.538211 0.461789 0.245528 0.133333 0.112195 7.369301 9.172358 NMV_2350 2193312 CDS +3 2250090 2254259 4170 validated/Curated no putative translocation and assembly module TamB 3 : Putative function from multiple computational evidences f : factor 7 : Outer membrane protein 2018-01-31 10:40:19 no 22466966 Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. 2 vladimir 0.227162 0.3214 0.27381 0.1776 0.595238 0.404762 0.269679 0.230321 0.364432 0.135569 0.594752 0.405248 0.258017 0.237609 0.231778 0.272595 0.469388 0.530612 0.15379 0.496356 0.225219 0.124636 0.721574 0.278426 0.637783 145107.5 -0.180817 0.355945 0.561634 0.226112 0.075857 0.560175 0.439825 0.227571 0.131291 0.09628 9.583717 8.694384 NMV_2351 2193313 CDS +3 2255331 2256788 1458 validated/Curated no putative peptide transporter 3 : Putative function from multiple computational evidences t : transporter 5 : Inner membrane protein 2018-01-27 17:08:32 no Belongs to a family of bacterial proton-dependent oligopeptide transporters. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. 2 vladimir 0.198217 0.3086 0.238683 0.254458 0.547325 0.452675 0.253086 0.209877 0.323045 0.213992 0.532922 0.467078 0.185185 0.255144 0.170782 0.388889 0.425926 0.574074 0.156379 0.460905 0.222222 0.160494 0.683128 0.316872 0.652975 52417.02 0.700412 0.336082 0.486598 0.280412 0.148454 0.707216 0.292784 0.131959 0.084536 0.047423 9.442513 8.360825 NMV_misc_RNA_5 2194964 misc_RNA -1 2257201 2257624 424 validated/Curated no rnpB ribonuclease P RNA component (RNaseP RNA; RNase P RNA) 2a : Function from experimental evidences in other organisms n : RNA 2 : Cytoplasmic 2.2.3 : RNA modification ; 2018-01-31 16:44:22 28334889 This is the RNA component of RNase P, which is a site-specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5' ends. The protein component is encoded by gene rnpA. vladimir NMV_2352 2193314 CDS -3 2257698 2258801 1104 validated/Curated no prfB peptide chain release factor II (RF-2) 2a : Function from experimental evidences in other organisms f : factor 2 : Cytoplasmic 2.3.2 : Translation ; 2018-01-27 17:08:46 no Helps terminate translation at TGA codons. 2 vladimir 0.28442 0.2518 0.271739 0.192029 0.523551 0.476449 0.266304 0.173913 0.404891 0.154891 0.578804 0.421196 0.391304 0.179348 0.171196 0.258152 0.350543 0.649457 0.195652 0.402174 0.23913 0.163043 0.641304 0.358696 0.759687 41459.68 -0.63733 0.253406 0.463215 0.201635 0.081744 0.482289 0.517711 0.33515 0.138965 0.196185 4.688011 10.095368 NMV_2353 2193315 CDS -3 2258904 2259797 894 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-14 18:33:21 no 1 vladimir 0.225951 0.2584 0.279642 0.236018 0.538031 0.461969 0.248322 0.177852 0.416107 0.157718 0.59396 0.40604 0.251678 0.271812 0.177852 0.298658 0.449664 0.550336 0.177852 0.325503 0.244966 0.251678 0.57047 0.42953 0.628626 30905.36 0.165993 0.356902 0.569024 0.245791 0.06734 0.619529 0.380471 0.185185 0.117845 0.06734 9.926903 8.821549 NMV_2355 2193317 CDS +2 2260139 2260588 450 validated/Curated no conserved hypothetical integral membrane protein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-14 18:32:55 no 1 vladimir 0.208889 0.2200 0.275556 0.295556 0.495556 0.504444 0.2 0.22 0.306667 0.273333 0.526667 0.473333 0.24 0.226667 0.166667 0.366667 0.393333 0.606667 0.186667 0.213333 0.353333 0.246667 0.566667 0.433333 0.608533 16629.93 0.479195 0.281879 0.469799 0.281879 0.134228 0.684564 0.315436 0.14094 0.073826 0.067114 6.759407 8.946309 NMV_2356 2193318 CDS +3 2260662 2260970 309 validated/Curated no conserved hypothetical periplasmic protein 4 : Unknown function but conserved in other organisms u : unknown 9 : Periplasmic 2008-04-14 18:32:34 no 2 vladimir 0.288026 0.2816 0.265372 0.165049 0.546926 0.453074 0.271845 0.067961 0.466019 0.194175 0.533981 0.466019 0.300971 0.378641 0.23301 0.087379 0.61165 0.38835 0.291262 0.398058 0.097087 0.213592 0.495146 0.504854 0.837228 9611.385 -0.4 0.607843 0.686275 0.078431 0.039216 0.54902 0.45098 0.254902 0.205882 0.04902 9.730797 8.431373 NMV_2357 2193319 CDS +1 2261086 2261928 843 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-20 14:30:28 no 2 vladimir 0.215896 0.2752 0.275208 0.233689 0.550415 0.449585 0.185053 0.24911 0.366548 0.199288 0.615658 0.384342 0.320285 0.224199 0.163701 0.291815 0.3879 0.6121 0.142349 0.352313 0.295374 0.209964 0.647687 0.352313 0.696553 31630.835 -0.175714 0.257143 0.475 0.228571 0.135714 0.578571 0.421429 0.289286 0.135714 0.153571 5.056297 10.064286 NMV_2358 2193320 CDS +2 2261918 2262664 747 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 2 : Cytoplasmic 2018-03-20 14:30:02 no 1 vladimir 0.273092 0.2744 0.220884 0.231593 0.495315 0.504685 0.232932 0.253012 0.305221 0.208835 0.558233 0.441767 0.35743 0.2249 0.148594 0.269076 0.373494 0.626506 0.228916 0.345382 0.208835 0.216867 0.554217 0.445783 0.637691 28507.805 -0.429839 0.254032 0.451613 0.197581 0.133065 0.520161 0.479839 0.241935 0.08871 0.153226 4.395561 9.681452 NMV_2359 2193321 CDS +2 2262686 2263273 588 validated/Curated no putative ECF-family RNA polymerase sigma factor 3 : Putative function from multiple computational evidences f : factor 2 : Cytoplasmic 2.2.2 : Transcription related ; 2018-01-27 17:09:54 no Belongs to a divergent subfamily of the sigma-70 family of sigma factors, known as ECF, that regulates genes encoding proteins with extracytoplasmic functions. 1 vladimir 0.314626 0.2585 0.210884 0.215986 0.469388 0.530612 0.27551 0.285714 0.244898 0.193878 0.530612 0.469388 0.372449 0.193878 0.153061 0.280612 0.346939 0.653061 0.295918 0.295918 0.234694 0.173469 0.530612 0.469388 0.549643 22577.69 -0.517949 0.230769 0.415385 0.215385 0.123077 0.471795 0.528205 0.266667 0.133333 0.133333 5.479057 9.035897 NMV_2360 2193322 CDS +1 2263279 2263458 180 validated/Curated no conserved hypothetical protein 4 : Unknown function but conserved in other organisms u : unknown 1 : Unknown 2008-04-14 18:31:02 no 2 vladimir 0.366667 0.2722 0.161111 0.2 0.433333 0.566667 0.383333 0.283333 0.133333 0.2 0.416667 0.583333 0.366667 0.25 0.166667 0.216667 0.416667 0.583333 0.35 0.283333 0.183333 0.183333 0.466667 0.533333 0.533766 7028.06 -0.810169 0.288136 0.355932 0.186441 0.101695 0.40678 0.59322 0.355932 0.271186 0.084746 9.959908 9.20339 NMV_2361 2193323 CDS +1 2263708 2264130 423 validated/Curated no conserved hypothetical lipoprotein 4 : Unknown function but conserved in other organisms u : unknown 11 : Membrane 2008-04-14 18:30:38 no 3 vladimir 0.35461 0.2624 0.160756 0.222222 0.423168 0.576832 0.41844 0.177305 0.198582 0.205674 0.375887 0.624113 0.333333 0.248227 0.148936 0.269504 0.397163 0.602837 0.312057 0.361702 0.134752 0.191489 0.496454 0.503546 0.555226 15922.705 -0.374286 0.3 0.485714 0.214286 0.1 0.464286 0.535714 0.221429 0.142857 0.078571 9.455223 8.95 NMV_2363 2193325 CDS +1 2265043 2265600 558 validated/Curated partial truncated IS1016 group transposase (C-terminal 85% of the protein) 5 : Unknown function e : enzyme 2 : Cytoplasmic 2008-04-14 18:30:03 no 1 vladimir 0.265233 0.2312 0.25448 0.249104 0.485663 0.514337 0.284946 0.209677 0.317204 0.188172 0.526882 0.473118 0.333333 0.145161 0.225806 0.295699 0.370968 0.629032 0.177419 0.33871 0.22043 0.263441 0.55914 0.44086 0.617086 21118.42 -0.4 0.237838 0.47027 0.227027 0.135135 0.524324 0.475676 0.308108 0.2 0.108108 9.764549 9.27027 NMV_2364 2193326 CDS -1 2265671 2266273 603 validated/Curated no tsaC threonylcarbamoyl-AMP synthase 2b : Function from indirect experimental evidences (e.g. phenotypes) e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.7.7.87 2018-01-27 17:10:53 no Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. 1 vladimir 0.25614 0.2211 0.278947 0.24386 0.5 0.5 0.263158 0.236842 0.278947 0.221053 0.515789 0.484211 0.263158 0.221053 0.247368 0.268421 0.468421 0.531579 0.242105 0.205263 0.310526 0.242105 0.515789 0.484211 0.492038 21105.15 -0.356085 0.291005 0.444444 0.227513 0.063492 0.555556 0.444444 0.26455 0.206349 0.058201 10.864601 9.433862 NMV_2365 2193327 CDS -1 2266307 2267578 1272 validated/Curated no purD phosphoribosylamine-glycine ligase (GARS; glycinamide ribonucleotide synthetase; phosphoribosylglycinamide synthetase) 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 1.5.2.1 : Purine biosynthesis ; 6.3.4.13 GLYRIBONUCSYN-RXN PWY-6121 2018-03-20 14:27:36 no Catalyses the second step in the de novo biosynthesis of purine: ATP + 5-phospho-D-ribosylamine + glycine <=> ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. 1 vladimir 0.268868 0.2130 0.284591 0.233491 0.497642 0.502358 0.273585 0.165094 0.436321 0.125 0.601415 0.398585 0.320755 0.238208 0.158019 0.283019 0.396226 0.603774 0.212264 0.235849 0.259434 0.292453 0.495283 0.504717 0.724452 44933.15 -0.061466 0.321513 0.567376 0.21513 0.085106 0.595745 0.404255 0.231678 0.106383 0.125296 4.962944 9.427896 NMV_2366 2193328 CDS +3 2267736 2268053 318 validated/Curated no hypothetical protein 5 : Unknown function u : unknown 2 : Cytoplasmic 2018-03-20 14:27:05 no 1 vladimir 0.305031 0.2013 0.248428 0.245283 0.449686 0.550314 0.207547 0.226415 0.349057 0.216981 0.575472 0.424528 0.433962 0.132075 0.198113 0.235849 0.330189 0.669811 0.273585 0.245283 0.198113 0.283019 0.443396 0.556604 0.654106 12648.67 -0.752381 0.209524 0.361905 0.190476 0.161905 0.47619 0.52381 0.371429 0.161905 0.209524 4.795464 10.380952 NMV_2367 2193329 CDS -3 2268105 2268716 612 validated/Curated no putative IMPACT-like protein 3 : Putative function from multiple computational evidences f : factor 1 : Unknown 2018-03-20 14:26:38 no The IMPACT protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. 1 vladimir 0.267974 0.1683 0.277778 0.285948 0.446078 0.553922 0.240196 0.161765 0.377451 0.220588 0.539216 0.460784 0.328431 0.22549 0.166667 0.279412 0.392157 0.607843 0.235294 0.117647 0.289216 0.357843 0.406863 0.593137 0.56633 22817.29 -0.14532 0.285714 0.492611 0.241379 0.118227 0.55665 0.44335 0.270936 0.142857 0.128079 6.509468 9.536946 NMV_2368 2193330 CDS -1 2268779 2269714 936 validated/Curated no etfA electron transfer flavoprotein alpha-subunit (alpha-ETF; electron transfer flavoprotein large subunit; ETFLS) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-27 17:12:00 no The electron transfer flavoprotein (ETF) serves as a specific electron acceptor. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunits. 3 vladimir 0.253205 0.1976 0.267094 0.282051 0.464744 0.535256 0.217949 0.157051 0.471154 0.153846 0.628205 0.371795 0.294872 0.282051 0.108974 0.314103 0.391026 0.608974 0.246795 0.153846 0.221154 0.378205 0.375 0.625 0.706146 32606.76 0.26881 0.327974 0.59164 0.270096 0.07717 0.610932 0.389068 0.205788 0.090032 0.115756 4.796959 9.141479 NMV_2369 2193331 CDS -3 2269725 2270474 750 validated/Curated no etfB electron transfer flavoprotein beta-subunit (beta-ETF; electron transfer flavoprotein small subunit; ETFSS) 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 1.4.3 : Electron carrier ; 2018-01-27 17:12:44 no The electron transfer flavoprotein (ETF) serves as a specific electron acceptor. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunits. 1 vladimir 0.298667 0.1907 0.268 0.242667 0.458667 0.541333 0.272 0.148 0.456 0.124 0.604 0.396 0.34 0.232 0.108 0.32 0.34 0.66 0.284 0.192 0.24 0.284 0.432 0.568 0.76297 26943.29 -0.024498 0.261044 0.518072 0.273092 0.036145 0.554217 0.445783 0.313253 0.160643 0.15261 6.968117 9.016064 NMV_2370 2193332 CDS -2 2270689 2271669 981 validated/Curated no rfaC lipooligosaccharide alpha-1,5 heptosyltransferase I 1b : Function from experimental evidences in the studied species e : enzyme 2 : Cytoplasmic 1.6.3 : Lipopolysaccharide ; 2.-.-.- 2018-01-27 17:13:02 no 7891550, 9198280 Catalyses the heptose transfer to the lipooligosaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA. 1 vladimir 0.269113 0.1906 0.27421 0.266055 0.464832 0.535168 0.24159 0.207951 0.357798 0.192661 0.565749 0.434251 0.324159 0.214067 0.165138 0.296636 0.379205 0.620795 0.24159 0.149847 0.299694 0.308868 0.449541 0.550459 0.6352 36438.775 -0.068712 0.273006 0.478528 0.245399 0.113497 0.58589 0.41411 0.245399 0.141104 0.104294 8.426949 9.365031 NMV_2371 2193333 CDS -2 2271706 2272341 636 validated/Curated no putative nicotinamidase (nicotine deamidase; NAMase) 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 3.5.1.19 NICOTINAMID-RXN PYRIDNUCSAL-PWY 2018-01-27 17:13:51 no Catalyses the following reaction: nicotinamide + H(2)O <=> nicotinate + NH(3). 1 vladimir 0.261006 0.1808 0.279874 0.278302 0.460692 0.539308 0.259434 0.165094 0.386792 0.188679 0.551887 0.448113 0.34434 0.226415 0.146226 0.283019 0.372642 0.627358 0.179245 0.150943 0.306604 0.363208 0.457547 0.542453 0.701319 23361.82 -0.073934 0.279621 0.511848 0.246445 0.104265 0.582938 0.417062 0.260664 0.113744 0.146919 4.782326 9.725118 NMV_2372 2193334 CDS +3 2272455 2273135 681 validated/Curated no trmO tRNA (adenine(37)-N6)-methyltransferase 2a : Function from experimental evidences in other organisms e : enzyme 2 : Cytoplasmic 2.2.3 : RNA modification ; 2.1.1.- 2018-01-30 15:53:08 no 25063302 Responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m6t6A37) of the tRNA anticodon loop of tRNA(Thr)(GGU). The methyl group of m6t6A37 appears to slightly improve the efficiency of the tRNA decoding ability. 2 vladimir 0.255507 0.3098 0.227606 0.207048 0.537445 0.462555 0.277533 0.251101 0.321586 0.14978 0.572687 0.427313 0.295154 0.237885 0.180617 0.286344 0.418502 0.581498 0.193833 0.440529 0.180617 0.185022 0.621145 0.378855 0.674724 25141.925 -0.216372 0.265487 0.504425 0.230088 0.10177 0.575221 0.424779 0.234513 0.123894 0.110619 7.028465 9.323009 NMV_2373 2193335 CDS -1 2273393 2274397 1005 validated/Curated no putative erythrose-4-phosphate dehydrogenase 3 : Putative function from multiple computational evidences e : enzyme 2 : Cytoplasmic 1.5.3.6 : Pyridoxine (vitamin B6) ; 1.2.1.72 ERYTH4PDEHYDROG-RXN PYRIDOXSYN-PWY 2020-02-26 13:56:00 no Catalyses the following reaction: D-erythrose 4-phosphate + NAD(+) + H(2)O <=> 4-phosphoerythronate + NADH 2 vladimir 0.254726 0.3144 0.240796 0.19005 0.555224 0.444776 0.274627 0.173134 0.414925 0.137313 0.58806 0.41194 0.301493 0.247761 0.161194 0.289552 0.408955 0.591045 0.18806 0.522388 0.146269 0.143284 0.668657 0.331343 0.816547 35842.405 -0.028144 0.329341 0.562874 0.242515 0.07485 0.565868 0.434132 0.230539 0.113772 0.116766 5.525414 9.57485 NMV_2374 2193336 CDS +2 2274839 2277433 2595 validated/Curated no mutS DNA mismatch repair protein MutS 2b : Function from indirect experimental evidences (e.g. phenotypes) f : factor 2 : Cytoplasmic 2.1.4 : DNA repair ; RXN0-2625 2018-01-27 17:14:20 no Plays a key role in the recognition and repair of errors made during the replication of DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. 2 vladimir 0.252408 0.3129 0.242004 0.192678 0.554913 0.445087 0.224277 0.267052 0.357225 0.151445 0.624277 0.375723 0.326012 0.248555 0.139884 0.285549 0.388439 0.611561 0.206936 0.423121 0.228902 0.14104 0.652023 0.347977 0.720111 95435.285 -0.229977 0.291667 0.476852 0.226852 0.097222 0.533565 0.466435 0.270833 0.142361 0.128472 5.9674 9.145833