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Gene History: CALS8_0014
» CURRENT ANNOTATION
MaGe curated annotation
Type
Begin
End
Length
Frame
Mutation
Gene
Synonyms
Status
CDS
fCDS
129 (42aa)
-3
no
frameshift
pseudo
partial
gene remnant
selenocysteine
pyrrolysine
atypical start
inProgress
finished
Curated
Artefact
chkSeq
chkStart
Product
Putative Histidine kinase-like ATPases
Product Type
c : carrier
cp : cell process
e : enzyme
f : factor
h : extrachromosomal origin
l : leader peptide
lp : lipoprotein
m : membrane component
n : RNA
ph : phenotype
r : regulator
rc : receptor
s : structure
t : transporter
u : unknown
EC number
Reaction
_
Localization
1 : Unknown
2 : Cytoplasmic
3 : Fimbrial
4 : Flagellar
5 : Inner membrane protein
6 : Inner membrane-associated
7 : Outer membrane protein
8 : Outer membrane-associated
9 : Periplasmic
10 : Secreted
11 : Membrane
BioProcess
Selection is empty.
1 : Amino acid biosynthesis
  1.1 : Aromatic amino acid family
  1.2 : Aspartate family
  1.3 : Glutamate family
  1.4 : Pyruvate family
  1.5 : Serine family
  1.6 : Histidine family
2 : Purines, pyrimidines, nucleosides, and nucleotides
  2.1 : 2'-Deoxyribonucleotide metabolism
  2.2 : Nucleotide and nucleoside interconversions
  2.3 : Purine ribonucleotide biosynthesis
  2.4 : Pyrimidine ribonucleotide biosynthesis
  2.5 : Salvage of nucleosides and nucleotides
  2.6 : Sugar-nucleotide biosynthesis and conversions
3 : Fatty acid and phospholipid metabolism
  3.1 : Biosynthesis
  3.2 : Degradation
4 : Biosynthesis of cofactors, prosthetic groups, and carriers
  4.1 : Biotin
  4.2 : Folic acid
  4.3 : Heme, porphyrin, and cobalamin
  4.4 : Lipoate
  4.5 : Menaquinone and ubiquinone
  4.6 : Molybdopterin
  4.7 : Pantothenate and coenzyme A
  4.8 : Pyridoxine
  4.9 : Riboflavin, FMN, and FAD
  4.10 : Glutathione and analogs
  4.11 : Thiamine
  4.12 : Pyridine nucleotides
  4.13 : Chlorophyll and bacteriochlorphyll
  4.14 : Siderophores
5 : Central intermediary metabolism
  5.1 : Amino sugars
  5.2 : One-carbon metabolism
  5.3 : Phosphorus compounds
  5.4 : Polyamine biosynthesis
  5.5 : Sulfur metabolism
  5.6 : Nitrogen fixation
  5.7 : Nitrogen metabolism
  5.8 : Electron carrier regeneration
6 : Energy metabolism
  6.1 : Aerobic
  6.2 : Amino acids and amines
  6.3 : Anaerobic
  6.4 : ATP-proton motive force interconversion
  6.5 : Electron transport
  6.6 : Entner-Doudoroff
  6.7 : Fermentation
  6.8 : Glycolysis/gluconeogenesis
  6.9 : Pentose phosphate pathway
  6.10 : Pyruvate dehydrogenase
  6.11 : Sugars
  6.12 : TCA cycle
  6.13 : Methanogenesis
  6.14 : Biosynthesis and degradation of polysaccharides
  6.15 : Photosynthesis
  6.16 : Chemoautotrophy
7 : Transport and binding proteins
  7.1 : Amino acids, peptides and amines
  7.2 : Anions
  7.3 : Carbohydrates, organic alcohols, and acids
  7.4 : Cations and iron carrying compounds
  7.5 : Nucleosides, purines and pyrimidines
  7.6 : Porins
  7.7 : Unknown substrate
8 : DNA metabolism
  8.1 : DNA replication, recombination, and repair
  8.2 : Restriction/modification
  8.3 : Degradation of DNA
  8.4 : Chromosome-associated proteins
9 : Transcription
  9.1 : Degradation of RNA
  9.2 : DNA-dependent RNA polymerase
  9.3 : Transcription factors
  9.4 : RNA processing
10 : Protein synthesis
  10.1 : tRNA aminoacylation
  10.2 : Ribosomal proteins: synthesis and modification
  10.3 : tRNA and rRNA base modification
  10.4 : Translation factors
11 : Protein fate
  11.1 : Protein and peptide secretion and trafficking
  11.2 : Protein modification and repair
  11.3 : Protein folding and stabilization
  11.4 : Degradation of proteins, peptides, and glycopeptides
12 : Regulatory functions
  12.1 : DNA interactions
  12.2 : RNA interactions
  12.3 : Protein interactions
  12.4 : Small molecule interactions
13 : Signal transduction
  13.1 : Two-component systems
  13.2 : PTS
14 : Cell envelope
  14.1 : Surface structures
  14.2 : Biosynthesis and degradation of murein sacculus and peptidoglycan
  14.3 : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
15 : Cellular processes
  15.1 : Cell division
  15.2 : Chemotaxis and motility
  15.3 : Cell adhesion
  15.4 : Conjugation
  15.5 : Detoxification
  15.6 : DNA transformation
  15.7 : Sporulation and germination
  15.8 : Toxin production and resistance
  15.9 : Pathogenesis
  15.10 : Adaptations to atypical conditions
  15.11 : Biosynthesis of natural products
  15.12 : Bioluminescence
16 : Biological processes
  16.1 : Circulate
  16.2 : Construct biomass (Anabolism)
  16.3 : Control
  16.4 : Excrete
  16.5 : Explore
  16.6 : Maintain
  16.7 : Manage energy
  16.8 : Protect
  16.9 : Replicate
  16.10 : Respire
  16.11 : Scavenge (Catabolism)
  16.12 : Sense
  16.13 : Shape
  16.14 : Store
  16.15 : Symbiosis
17 : Mobile and extrachromosomal element functions
  17.1 : Plasmid functions
  17.2 : Prophage functions
  17.3 : Transposon functions
18 : Unknown function
  18.1 : Enzymes of unknown specificity
19 : Unclassified
Roles
Selection is empty.
1 : Metabolism
  1.1 : Carbon compound utilization
   1.1.1 : Carbohydrates/Carbon compounds
    1.1.1.1 : D-allose catabolism
    1.1.1.2 : 2,5-ketogluconate metabolism
    1.1.1.3 : D-arabinose catabolism
    1.1.1.4 : D-galactarate catabolism
    1.1.1.5 : D-galacturonate catabolism
    1.1.1.6 : D-glucarate catabolism
    1.1.1.7 : D-glucuronate catabolism
    1.1.1.8 : L-arabinose catabolism
    1.1.1.9 : L-idonate catabolism
    1.1.1.10 : L-lyxose metabolism
    1.1.1.11 : Fucose catabolism
    1.1.1.12 : Galactitol catabolism
    1.1.1.13 : Galactonate catabolism
    1.1.1.14 : Lactose degradation
    1.1.1.15 : Mannose catabolism
    1.1.1.16 : Rhamnose catabolism
    1.1.1.17 : Sorbitol degradation
    1.1.1.18 : Trehalose degradation, low osmolarity+
    1.1.1.19 : Xylose catabolism
    1.1.1.20 : Glycol degradation
    1.1.1.21 : Mannitol degradation
    1.1.1.22 : Ribose degradation
    1.1.1.23 : Galactose degradation
    1.1.1.24 : Sorbose degradation
    1.1.1.25 : L-ascorbate degradation
   1.1.2 : Fatty acids (fatty acid oxidation)
    1.1.2.1 : Degradation of short-chain fatty acids
    1.1.2.2 : 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation
    1.1.2.3 : Propionate degradation
   1.1.3 : Amino acids
    1.1.3.1 : L-alanine degradation
    1.1.3.2 : L-serine degradation
    1.1.3.3 : Arginine catabolism
    1.1.3.4 : Glutamate degradation
    1.1.3.5 : Glycine cleavage
    1.1.3.6 : Proline utilization
    1.1.3.7 : Threonine catabolism
    1.1.3.8 : Tryptophan utilization
    1.1.3.9 : L-cysteine catabolism
    1.1.3.10 : Lysine cleavage
    1.1.3.11 : Histidine degradation
    1.1.3.12 : Leucine degradation
    1.1.3.13 : Methionine degradation
    1.1.3.14 : Valine degradation
    1.1.3.15 : Phenylalanine, tyrosine degradation
   1.1.4 : Amines
    1.1.4.1 : Phenylethylamine degradation
    1.1.4.2 : Carnitine degradation
    1.1.4.3 : Ornithine degradation
   1.1.5 : Others
    1.1.5.1 : Phenylacetic acid degradation
    1.1.5.2 : Ethanol degradation
    1.1.5.3 : Eugenol catabolism
    1.1.5.4 : Beta-ketoadipate pathway
    1.1.5.5 : Mandelate catabolism
  1.2 : Macromolecule degradation
   1.2.1 : RNA
   1.2.2 : DNA
   1.2.3 : Proteins/peptides/glycopeptides
   1.2.4 : Polysaccharides
    1.2.4.1 : Glycogen catabolism
    1.2.4.2 : Chitin catabolism
  1.3 : Energy metabolism (carbon)
   1.3.1 : Glycolysis
   1.3.2 : Pentose phosphate shunt, oxidative branch
   1.3.3 : Pyruvate dehydrogenase
   1.3.4 : Tricarboxylic acid cycle
   1.3.5 : Fermentation
   1.3.6 : Aerobic respiration
   1.3.7 : Anaerobic respiration
   1.3.8 : ATP proton motive force interconversion
   1.3.9 : Entner-Doudoroff pathway
  1.4 : Energy production/transport
   1.4.1 : Electron donor
   1.4.2 : Electron acceptor
   1.4.3 : Electron carrier
  1.5 : Building block biosynthesis
   1.5.1 : Amino acids
    1.5.1.1 : Glutamate
    1.5.1.2 : Glutamine
    1.5.1.3 : Arginine
    1.5.1.4 : Proline
    1.5.1.5 : Aspartate
    1.5.1.6 : Asparagine
    1.5.1.7 : Lysine, diaminopimelate
    1.5.1.8 : Threonine
    1.5.1.9 : Methionine
    1.5.1.10 : Glycine
    1.5.1.11 : Serine
    1.5.1.12 : Cysteine
    1.5.1.13 : Phenylalanine
    1.5.1.14 : Tyrosine
    1.5.1.15 : Tryptophan
    1.5.1.16 : Histidine
    1.5.1.17 : Alanine
    1.5.1.18 : Isoleucine/valine
    1.5.1.19 : Leucine
    1.5.1.20 : Chorismate
    1.5.1.21 : Homoserine
   1.5.2 : Nucleotide
    1.5.2.1 : Purine biosynthesis
    1.5.2.2 : Pyrimidine biosynthesis
    1.5.2.3 : Purine ribonucleotide biosynthesis
    1.5.2.4 : Pyrimidine ribonucleotide/ribonucleoside biosynthesis
   1.5.3 : Cofactor, small molecule carrier
    1.5.3.1 : Biotin
    1.5.3.2 : Folic acid
    1.5.3.3 : Lipoate
    1.5.3.4 : Molybdenum (molybdopterin)
    1.5.3.5 : Coenzyme A
    1.5.3.6 : Pyridoxine (vitamin B6)
    1.5.3.7 : Nicotinamide adenine dinucleotide (NAD)
    1.5.3.8 : Thiamine (Vitamin B1)
    1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN
    1.5.3.10 : Glutathione
    1.5.3.11 : Menaquinone (MK), ubiquinone (Q)
    1.5.3.12 : Heme, porphyrin
    1.5.3.13 : Cobalamin (Vitamin B12)
    1.5.3.14 : Enterochelin (enterobactin)
    1.5.3.15 : Chrysobactin
    1.5.3.16 : Achromobactin
    1.5.3.19 : Isoprenoid biosynthesis
    1.5.3.20 : Tetrahydrobiopterin biosynthesis
    1.5.3.21 : Pyochelin biosynthesis
   1.5.4 : Fatty acid and phosphatidic acid
  1.6 : Macromolecules (cellular constituent) biosynthesis
   1.6.1 : Phospholipid
   1.6.2 : Colanic acid (M antigen)
   1.6.3 : Lipopolysaccharide
    1.6.3.1 : O antigen
    1.6.3.2 : Core region
    1.6.3.3 : Lipid A
   1.6.4 : Enterobacterial common antigen (surface glycolipid)
   1.6.5 : K antigen
   1.6.6 : Osmoregulated periplasmic glucan
   1.6.7 : Peptidoglycan (murein)
   1.6.9 : Polysaccharides, cytoplasmic
   1.6.10 : Lipoprotein
   1.6.11 : Glycoprotein
   1.6.12 : Flagella
   1.6.13 : Fimbria, pili, curli
   1.6.15 : Large molecule carriers
    1.6.15.1 : Cytochromes
    1.6.15.2 : Thioredoxin, glutaredoxin
    1.6.15.3 : Biotin carboxyl carrier protein
    1.6.15.4 : Acyl carrier protein
   1.6.16 : Cellulose biosynthesis
  1.7 : Central intermediary metabolism
   1.7.1 : Unassigned reversible reactions
   1.7.2 : Glyoxylate bypass
   1.7.3 : Pentose phosphate shunt, non-oxidative branch
   1.7.6 : Glycerol metabolism
   1.7.7 : Galactose metabolism
   1.7.8 : Gluconeogenesis
   1.7.9 : Misc. glucose metabolism
   1.7.10 : Sugar nucleotide biosynthesis, conversions
   1.7.12 : Amino sugar conversions
   1.7.13 : Amino acid conversion
   1.7.14 : Polyamine biosynthesis
   1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism
   1.7.17 : Formyl-tetrahydrofolate biosynthesis
   1.7.18 : Betaine biosynthesis
   1.7.19 : Incorporation of metal ions
   1.7.20 : S-adenosyl methionine biosynthesis
   1.7.21 : Glyoxylate degradation
   1.7.22 : Carnitine metabolism
   1.7.23 : Methylglyoxal metabolism
   1.7.24 : Cyanate catabolism
   1.7.25 : Glycolate metabolism
   1.7.26 : Allantoin assimilation
   1.7.27 : Pyridoxal 5'-phosphate salvage
   1.7.28 : Pyruvate catabolism
   1.7.29 : Acetate catabolism
   1.7.31 : Aminobutyrate catabolism
   1.7.32 : Putrescine catabolism
   1.7.33 : Nucleotide and nucleoside conversions
   1.7.34 : Peptidoglycan (murein) turnover, recycling
   1.7.35 : Lactate oxidation
   1.7.36 : Trehalose biosynthesis
   1.7.37 : C1 assimilation, serine pathway
   1.7.38 : Methionine salvage pathway
  1.8 : Metabolism of other compounds
   1.8.1 : Phosphorous metabolism
   1.8.2 : Sulfur metabolism
   1.8.3 : Nitrogen metabolism
2 : Information transfer
  2.1 : DNA related
   2.1.1 : DNA replication
   2.1.2 : DNA restriction/modification
   2.1.3 : DNA recombination
   2.1.4 : DNA repair
   2.1.5 : DNA degradation
  2.2 : RNA related
   2.2.2 : Transcription related
   2.2.3 : RNA modification
   2.2.4 : RNA degradation
   2.2.5 : tRNA
   2.2.6 : rRNA, stable RNA
   2.2.7 : Antisense RNA
  2.3 : Protein related
   2.3.1 : Amino acid-activation
   2.3.2 : Translation
   2.3.3 : Posttranslational modification
   2.3.4 : Chaperoning, folding
   2.3.5 : Export, signal peptide cleavage
   2.3.6 : Turnover, degradation
   2.3.7 : Nucleoproteins, basic proteins
   2.3.8 : Ribosomal proteins
   2.3.9 : Non-ribosomal peptide synthetase
3 : Regulation
   3.1. : Type of regulation
   3.1.1 : DNA structure level
    3.1.1.1 : DNA bending, supercoiling, inversion
    3.1.1.2 : Methylation
   3.1.2 : Transcriptional level
    3.1.2.1 : Sigma factors, anti-sigmafactors
    3.1.2.2 : Activator
    3.1.2.3 : Repressor
    3.1.2.4 : Complex regulation
     3.1.2.4.1 : More than one signal needed
     3.1.2.4.2 : Regulons or multilayer component regulatory systems
     3.1.2.4.3 : Two-component regulatory systems (external signal)
     3.1.2.4.4 : Quorum sensing
    3.1.2.5 : Action unknown
   3.1.3 : Posttranscriptional
    3.1.3.1 : Translation attenuation and efficiency
    3.1.3.2 : Covalent modification, demodification, maturation
    3.1.3.3 : Inhibition / activation of enzymes
    3.1.3.4 : Proteases, cleavage of compounds
    3.1.3.5 : Multilayer regulatory systems
    3.1.3.6 : Antisense RNA
   3.1.4 : Regulation level unknown
  3.3 : Genetic unit regulated
   3.3.1 : Operon (regulation of one operon)
   3.3.2 : Regulon (a network of operons encoding related functions)
   3.3.3 : Stimulon (ie. environmental stimulus)
   3.3.4 : Global
  3.4 : Trigger (some information added)
  3.5 : Trigger modulation (some information added)
4 : Transport
  4.1 : Channel-type Transporters
    4.1.A. : alpha-type channels
     4.1.A.1. : The Voltage-gated Ion Channel (VIC) Superfamily
     4.1.A.8. : The Major Intrinsic Protein (MIP) Family
    4.1.A.11 : The Chloride Channel (ClC) Family
    4.1.B.17 : The Outer Membrane Factor (OMF) Family
    4.1.A.22 : The Large Conductance Mechanosensitive Ion Channel (MscL) Family
    4.1.A.23 : The Small Conductance Mechanosensitive Ion Channel (MscS) Family
    4.1.A.46 : The H+- or Na+-translocating Bacterial Flagellar Motor (Mot) Family
   4.1.B : Beta barrel porins (The Outer Membrane Porin (OMP) Functional Superfamily)
    4.1.B.1 : The General Bacterial Porin (GBP) Family
    4.1.B.3 : The Sugar Porin (SP) Family
    4.1.B.9 : The FadL Outer Membrane Protein (FadL) Family
    4.1.B.10 : The Nucleoside-specific Channel-forming Outer Membrane Porin (Tsx) Family
    4.1.B.14 : The Outer Membrane Receptor (OMR) Family
    4.1.B.21 : The OmpG Porin (OmpG) Family
  4.2 : Electrochemical potential driven transporters
    4.2.A. : Porters (Uni-, Sym- and Antiporters)
    4.2.A.1 : The Major Facilitator Superfamily (MFS)
    4.2.A.2 : The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
    4.2.A.3 : The Amino Acid-Polyamine-Choline (APC) Family
    4.2.A.4 : The Cation Diffusion Facilitator (CDF) Family
    4.2.A.6 : The Resistance-Nodulation-Cell Division (RND) Superfamily
    4.2.A.7 : The Drug/Metabolite Transporter (DMT) Superfamily
    4.2.A.8 : The Gluconate:H+ Symporter (GntP) Family
    4.2.A.9 : The Cytochrome oxidase biogenesis (Oxa1) Family
    4.2.A.10 : The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family
    4.2.A.13 : The C4-Dicarboxylate Uptake (Dcu) Family
    4.2.A.14 : The Lactate Permease (LctP) Family
    4.2.A.15 : The Betaine/Carnitine/Choline Transporter (BCCT) Family
    4.2.A.16 : The Telurite-resistance/Dicarboxylate Transporter (TDT) Family
    4.2.A.17 : The Proton-dependent Oligopeptide Transporter (POT) Family
    4.2.A.19 : The Ca2+:Cation Antiporter (CaCA) Family
    4.2.A.20 : The Inorganic Phosphate Transporter (PiT) Family
    4.2.A.21 : The Solute:Sodium Symporter (SSS) Family
    4.2.A.23 : The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
    4.2.A.25 : The Alanine/Glycine:Cation symporter (AGCS) Family
    4.2.A.26 : The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
    4.2.A.27 : The Glutamate:Na+ Symporter (GltS) Family
    4.2.A.33 : The NhaA Na+:H+ Antiporter (NhaA) Family
    4.2.A.34 : The NhaB Na+:H+ Antiporter (NhaB) Family
    4.2.A.36 : The Monovalent Cation:Proton Antiporter-1 (CPA1) Family
    4.2.A.37 : The Monovalent Cation:Proton Antiporter-2 (CPA2) Family
    4.2.A.38 : The K+ Transporter (Trk) Family
    4.2.A.39 : The Nucleobase:Cation Symporter-1 (NCS1) Family
    4.2.A.40 : The Nucleobase:Cation Symporter-2 (NCS2) Family
    4.2.A.41 : The Concentrative Nucleoside Transporter (CNT) Family
    4.2.A.42 : The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
    4.2.A.44 : The Formate-Nitrite Transporter (FNT) Family
    4.2.A.45 : The Metal Ion Transporter (MIT) Family
    4.2.A.47 : The Divalent Anion:Na+ Symporter (DASS) Family
    4.2.A.49 : The Ammonium Transporter (Amt) Family
    4.2.A.53 : The Sulfate Permease (SulP) Family
    4.2.A.55 : The Manganese (Nramp) Fam.
    4.2.A.58 : The Phosphate:Na+ Symporter (PNaS) Family
    4.2.A.61 : The C4-dicarboxylate Uptake C (DcuC) Family
    4.2.A.64 : The Type V Secretory Pathway or Twin Arginine Targeting (Tat) Family
    4.2.A.66 : The Multi Antimicrobial Extrusion (MATE) Family
    4.2.A.68 : The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
    4.2.A.69 : The Auxin Efflux Carrier (AEC) Family
    4.2.A.72 : The K+ uptake permease (KUP) family
    4.2.A.75 : The L-lysine exporter (LysE) family
    4.2.A.76 : The Resistance to Homoserine/Threonine (RhtB) Family
   4.2.C : Ion-gradient driven energizers
    4.2.C.1 : TonB Family of Auxiliary Proteins for Energization of OMR-mediated Transport
  4.3 : Primary Active Transporters
    4.3.A. : Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters
    4.3.A.1 : The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases
     4.3.A.1.a : ATP binding component
     4.3.A.1.m : membrane component
     4.3.A.1.p : periplasmic binding component
     4.3.A.1.am : ATP binding and membrane component
    4.3.A.2 : The H+/Na+-translocating F-, V- and A-type ATPase (F-ATPase) Superfamily
    4.3.A.3 : The P-type ATPase (P-ATPase) Superfamily
    4.3.A.4 : The Arsenite-Antimonite (Ars) Efflux Family
    4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family
    4.3.A.6 : The Type III (Virulence-related) Secretory Pathway (IIISP) Family
    4.3.A.7 : The Type IV (Conjugal DNA-Protein Transfer) Secretory Pathway (IVSP) Family
    4.3.D. : Oxidoreduction-driven Active Transporters
    4.3.D.1 : The Proton- or sodium ion-translocating NADH Dehydrogenase (NDH) Family
    4.3.D.4 : The Proton-translocating Cytochrome Oxidase (COX) Superfamily
  4.4 : Group Translocators
   4.4.A : Phosphotransferase Systems (PEP-dependent PTS)
    4.4.A.1 : The PTS Glucose-Glucoside (Glc) Family
    4.4.A.2 : The PTS Fructose-Mannitol (Fru) Family
    4.4.A.3 : The PTS Lactose-N,N'-Diacetylchitobiose-betaucoside (Lac) Family
    4.4.A.4 : The PTS Glucitol (Gut) Family
    4.4.A.5 : The PTS Galactitol (Gat) Family
    4.4.A.6 : The PTS Mannose-Fructose-Sorbose (Man) Family
   4.8.A : Accessory Factors Involved in Transport
    4.8.A.1 : The Membrane Fusion Protein (MFP) Family
    4.8.A.2 : The Secretin Auxiliary Lipoprotein (SAL) Family
    4.8.A.3 : MPA1 Family auxillary transport protein
    4.8.A.7 : The Phosphotransferase System Enzyme I (EI) Family
    4.8.A.8 : The Phosphotransferase System HPr (HPr) Family
   4.9.A : Transporters of Unknown Classification
    4.9.A.1 : The Polysaccharide Transporter (PST) Family
    4.9.A.4 : The Nicotinamide Mononucleotide (NMN) Uptake Permease (PnuC) Family
    4.9.A.8 : The Ferrous Iron Uptake (FeoB) Family
    4.9.A.13 : The Short Chain Fatty Acid Transporter (scFAT) Family
    4.9.A.16 : The Septal DNA Translocator (SDT) Family
    4.9.A.17 : The Metal Ion Transporter (MIT) Family
   4.9.B : Putative uncharacterized transport protein
    4.9.B.3 : The Putative Bacterial Murein Precursor Exporter (MPE) Family
    4.9.B.4 : The Putative Efflux Transporter (PET) Family
    4.9.B.6 : The Toxic Hok/Gef Protein (Hok/Gef) Family
    4.9.B.10 : The 6TMS Putative MarC Transporter (MarC) Family
    4.9.B.18 : The SecDF-associated Single Transmembrane Protein (SSTP) Family
    4.9.B.21 : The Frataxin (Frataxin) Family
    4.9.B.22 : The Putative Permease (PerM) Family
    4.9.B.24 : The Testis-Enhanced Gene Transfer (TEGT) Family
    4.9.B.25 : The YbbM (YbbM) Family
    4.9.B.27 : The YdjX-Z (YdjX-Z) Family
    4.9.B.28 : The YqaE (YqaE) Family
    4.9.B.29 : The YebN (YebN) Family
    4.9.B.31 : The YqiH (YqiH) Family
    4.9.B.32 : The Putative Vectorial Glycosyl Polymerization (VGP) Family
  4.S : substrate
   4.S.1 : (D)-glucarate/galactarate
   4.S.10 : allose/ribose
   4.S.100 : L-arabinose
   4.S.101 : L-arabinose /H+
   4.S.102 : L-arabinose/ isopropyl-beta-D-thiogalactopyranoside
   4.S.103 : L-asparagine
   4.S.104 : lipooligosaccharides
   4.S.105 : lipopolysaccharide
   4.S.106 : lipoprotein
   4.S.107 : L-lactate
   4.S.108 : L-leucine/L-valine/L-iso-leucine
   4.S.109 : L-rhamnose/H+
   4.S.11 : alpha-ketoglutarate
   4.S.110 : L-threonine/L-serine
   4.S.111 : lysine
   4.S.112 : lysine/arginine/ornithine
   4.S.113 : maltose
   4.S.114 : maltose/maltodextrin
   4.S.115 : mannitol
   4.S.116 : mannose
   4.S.117 : mellobiose
   4.S.118 : methionine
   4.S.119 : methylgalactoside/galactose
   4.S.12 : amino acid
   4.S.120 : Mg++
   4.S.121 : Mg2+/Ni2+/Co2+
   4.S.122 : microcin B17
   4.S.123 : Mn+/H+
   4.S.124 : molybdate
   4.S.125 : molybdenum
   4.S.126 : multidrug
   4.S.127 : multidrug/bicyclomycin
   4.S.128 : muropeptide
   4.S.129 : myo-inositor
   4.S.13 : amino acid/amide
   4.S.130 : Na+
   4.S.131 : Na+/ alanine/glycine
   4.S.132 : Na+/ H+
   4.S.133 : Na+/Ca+
   4.S.134 : Na+/dicarboxylate
   4.S.135 : Na+/glutamate/aspartate
   4.S.136 : Na+/H+
   4.S.137 : Na+/leucine/valine/iso-leucine
   4.S.138 : Na+/pantothenate
   4.S.139 : Na+/proline
   4.S.14 : ammonium
   4.S.140 : Na+/serine/threonine
   4.S.141 : N-acetylgalactosamine
   4.S.142 : N-acetylglucosamine
   4.S.143 : Ni++
   4.S.144 : nicotinamide mononucleotide
   4.S.145 : nitrite
   4.S.146 : nucleoside
   4.S.147 : nucleoside/H+
   4.S.148 : oligopeptide
   4.S.149 : oligopeptides
   4.S.15 : antibiotic
   4.S.150 : p-aminobenzoyl-glutamate
   4.S.151 : Pb/Cd/Zn/Hg
   4.S.152 : peptide
   4.S.153 : phenylalanine
   4.S.154 : phenylalanine/ tyrosine
   4.S.155 : phosphate
   4.S.156 : polymyxin
   4.S.157 : potassium
   4.S.158 : proline
   4.S.159 : proline/betaine
   4.S.16 : arabinose polymer
   4.S.160 : protein
   4.S.161 : protein/DNA
   4.S.162 : purine/xanthine
   4.S.163 : putrescine
   4.S.164 : putrescine/ornithine
   4.S.165 : putrescine/ornitine
   4.S.166 : putrescine/spermidine
   4.S.167 : serine
   4.S.168 : shikimate/dehydroshikimate
   4.S.169 : sialic acid
   4.S.17 : arginine
   4.S.170 : S-methylmethionine
   4.S.171 : spermidine/putrescine
   4.S.172 : sucrose
   4.S.173 : sugar
   4.S.174 : sulfate
   4.S.175 : taurine
   4.S.176 : tellurite
   4.S.177 : thiamine
   4.S.178 : thiosulfate
   4.S.179 : thiosulfate/sulfate
   4.S.18 : arginine/ornitine
   4.S.180 : threonine
   4.S.181 : trehalose
   4.S.182 : tripeptide
   4.S.183 : tryptophan
   4.S.184 : tyrosine
   4.S.185 : uracil
   4.S.186 : urasil
   4.S.187 : vitamin B12
   4.S.188 : water
   4.S.189 : xanthosine
   4.S.19 : arsenite
   4.S.190 : xylose/H+
   4.S.191 : Zn
   4.S.192 : chrysobactin
   4.S.193 : achromobactin
   4.S.2 : 2-keto-3-deoxy-D-gluconate
   4.S.20 : benzoate
   4.S.21 : beta-galactosidase/lactose and glucose
   4.S.22 : beta-glucoside
   4.S.23 : betaine/choline/glycine
   4.S.24 : betaine/choline/glycine transport protein
   4.S.25 : Ca+/ H+
   4.S.26 : cadaverine/lysine
   4.S.27 : carnitine
   4.S.28 : cation
   4.S.29 : cellobiose/arbutin/salicin
   4.S.3 : 3-hydroxyphenylpropionic acid
   4.S.30 : cellobiose/salicin/arbutin
   4.S.31 : chloramphenicol
   4.S.32 : chloride
   4.S.33 : choline
   4.S.34 : citrate/succinate
   4.S.35 : colicin4
   4.S.36 : Cu
   4.S.37 : curli subunit
   4.S.38 : cyanate
   4.S.39 : cysteine
   4.S.4 : 3-phenylpropionic acid
   4.S.40 : cysteine/O-acetyl-L-serine/cysteine metabolites
   4.S.41 : cytosine
   4.S.42 : D-alanine/D-serine/glycine
   4.S.43 : D-galactonate
   4.S.44 : D-glucarate
   4.S.45 : D-glucose/trehalose
   4.S.46 : dicarboxylate
   4.S.47 : dipeptide
   4.S.48 : D-ribose
   4.S.49 : drug
   4.S.5 : alkanesulfonate
   4.S.50 : D-xylose
   4.S.51 : enterochelin
   4.S.52 : fatty acid
   4.S.53 : Fe
   4.S.54 : Fe++
   4.S.55 : ferric dicitrate
   4.S.56 : ferric enterobactin
   4.S.57 : ferric hydroxamate
   4.S.58 : ferrichrome
   4.S.59 : formate
   4.S.6 : alkanesulphonate
   4.S.60 : formate/oxalate
   4.S.61 : fosfidomycin/H+
   4.S.62 : frucose
   4.S.63 : fructose
   4.S.64 : fucose
   4.S.65 : galactitol
   4.S.66 : galactose/H+
   4.S.67 : gamma-aminobutyrate
   4.S.68 : glucitol/sorbitol
   4.S.69 : gluconate
   4.S.7 : alklphosphonate
   4.S.70 : gluconate/L-idonate
   4.S.71 : glucose
   4.S.72 : glucose/maltose
   4.S.73 : glucuronide
   4.S.74 : glutamate/aminobutyric acid
   4.S.75 : glutamate/aspartate
   4.S.76 : glutamine
   4.S.77 : glycerol
   4.S.78 : glycerol-3-P
   4.S.79 : glycine betaine choline transport
   4.S.8 : alkylphosphonate
   4.S.80 : glycine/betaine/proline
   4.S.81 : group A colicins
   4.S.82 : H+
   4.S.83 : H+/acridine
   4.S.84 : H+/lactose/glucose
   4.S.85 : heme
   4.S.86 : hexose phosphate
   4.S.87 : hexuronate
   4.S.88 : histidine
   4.S.89 : histidine/lysine/arginine/ornithine
   4.S.9 : allantoin/ion
   4.S.90 : homoserine/lactone
   4.S.91 : hydrophilic molecule
   4.S.92 : hydrophilic molecules
   4.S.93 : ion
   4.S.94 : ions
   4.S.95 : iron dicitrate
   4.S.96 : K+
   4.S.97 : K+/H+
   4.S.98 : lactate
   4.S.99 : lactose
5 : Cell processes
  5.1 : Cell division
  5.2 : Cell cycle physiology
  5.3 : Motility (incl. chemotaxis, energytaxis, aerotaxis, redoxtaxis)
  5.4 : Genetic exchange, recombination
  5.5 : Adaptation to stress
   5.5.1 : Osmotic pressure
   5.5.2 : Temperature extremes
   5.5.3 : Starvation response
   5.5.4 : pH response
   5.5.5 : Dessication
   5.5.6 : Other stresses (mechanical, nutritional, oxidative)
   5.5.7 : Fe aquisition
  5.6 : Protection
   5.6.1 : Radiation
   5.6.2 : Detoxification (xenobiotic metabolism)
   5.6.3 : Cell killing
   5.6.4 : Drug resistance/sensitivity
  5.8 : SOS response
  5.10 : Defense/survival
  5.11 : DNA uptake
  5.12 : Biofilm production
  5.13 : Virulence associated
6 : Cell structure
  6.1 : Membrane
  6.2 : Peptidoglycan (murein)
  6.3 : Surface antigens (ECA, O antigen of LPS)
  6.4 : Flagellum
  6.5 : Pilus
  6.6 : Ribosome
  6.7 : Capsule (M and K antigens)
7 : Location of gene products
  7.1 : Cytoplasm
  7.2 : Periplasmic space
  7.3 : Inner membrane
  7.4 : Outer membrane
  7.5 : Extracellular
8 : extrachromosomal
  8.1 : Prophage genes and phage related functions
   8.1.1 : DNA packaging, phage assembly
   8.1.2 : Replication
   8.1.3 : Regulation
   8.1.4 : Integration, recombination
   8.1.5 : Lysis
   8.1.6 : Structural component
  8.2 : Plasmid related
   8.2.1 : replication and maintenance
   8.2.2 : plasmid transfer
  8.3 : Transposon related
   8.3.1 : transposases
   8.3.2 : regulation of mobility
  8.4 : Colicin related
9 : DNA sites
10 : cryptic genes
PubMedId
Note
Additional Data
Comment
Interaction
Phenotype
SMILES
Internal comment
Selection is empty.
DBxref
PDB
PubChem
ChEMBL
ChEBI
DOI
Selection is empty.
Class
1a : Function from experimental evidences in the studied strain
1b : Function from experimental evidences in the studied species
1c : Function from experimental evidences in the studied genus
2a : Function from experimental evidences in other organisms
2b : Function from indirect experimental evidences (e.g. phenotypes)
3 : Putative function from multiple computational evidences
4 : Unknown function but conserved in other organisms
5 : Unknown function
» PRIMARY ANNOTATION
MicroScope pipeline
Type
Begin
End
Length
Frame
Mutation
Gene
Synonyms
Status
CDS
fCDS
129 (42aa)
-3
no
frameshift
pseudo
partial
gene remnant
selenocysteine
pyrrolysine
atypical start
inProgress
finished
Curated
Artefact
chkSeq
chkStart
Product
Phosphate regulon sensor protein PhoR
Product Type
c : carrier
cp : cell process
e : enzyme
f : factor
h : extrachromosomal origin
l : leader peptide
lp : lipoprotein
m : membrane component
n : RNA
ph : phenotype
r : regulator
rc : receptor
s : structure
t : transporter
u : unknown
EC number
Reaction
_
Localization
1 : Unknown
2 : Cytoplasmic
3 : Fimbrial
4 : Flagellar
5 : Inner membrane protein
6 : Inner membrane-associated
7 : Outer membrane protein
8 : Outer membrane-associated
9 : Periplasmic
10 : Secreted
11 : Membrane
BioProcess
Selection is empty.
1 : Amino acid biosynthesis
  1.1 : Aromatic amino acid family
  1.2 : Aspartate family
  1.3 : Glutamate family
  1.4 : Pyruvate family
  1.5 : Serine family
  1.6 : Histidine family
2 : Purines, pyrimidines, nucleosides, and nucleotides
  2.1 : 2'-Deoxyribonucleotide metabolism
  2.2 : Nucleotide and nucleoside interconversions
  2.3 : Purine ribonucleotide biosynthesis
  2.4 : Pyrimidine ribonucleotide biosynthesis
  2.5 : Salvage of nucleosides and nucleotides
  2.6 : Sugar-nucleotide biosynthesis and conversions
3 : Fatty acid and phospholipid metabolism
  3.1 : Biosynthesis
  3.2 : Degradation
4 : Biosynthesis of cofactors, prosthetic groups, and carriers
  4.1 : Biotin
  4.2 : Folic acid
  4.3 : Heme, porphyrin, and cobalamin
  4.4 : Lipoate
  4.5 : Menaquinone and ubiquinone
  4.6 : Molybdopterin
  4.7 : Pantothenate and coenzyme A
  4.8 : Pyridoxine
  4.9 : Riboflavin, FMN, and FAD
  4.10 : Glutathione and analogs
  4.11 : Thiamine
  4.12 : Pyridine nucleotides
  4.13 : Chlorophyll and bacteriochlorphyll
  4.14 : Siderophores
5 : Central intermediary metabolism
  5.1 : Amino sugars
  5.2 : One-carbon metabolism
  5.3 : Phosphorus compounds
  5.4 : Polyamine biosynthesis
  5.5 : Sulfur metabolism
  5.6 : Nitrogen fixation
  5.7 : Nitrogen metabolism
  5.8 : Electron carrier regeneration
6 : Energy metabolism
  6.1 : Aerobic
  6.2 : Amino acids and amines
  6.3 : Anaerobic
  6.4 : ATP-proton motive force interconversion
  6.5 : Electron transport
  6.6 : Entner-Doudoroff
  6.7 : Fermentation
  6.8 : Glycolysis/gluconeogenesis
  6.9 : Pentose phosphate pathway
  6.10 : Pyruvate dehydrogenase
  6.11 : Sugars
  6.12 : TCA cycle
  6.13 : Methanogenesis
  6.14 : Biosynthesis and degradation of polysaccharides
  6.15 : Photosynthesis
  6.16 : Chemoautotrophy
7 : Transport and binding proteins
  7.1 : Amino acids, peptides and amines
  7.2 : Anions
  7.3 : Carbohydrates, organic alcohols, and acids
  7.4 : Cations and iron carrying compounds
  7.5 : Nucleosides, purines and pyrimidines
  7.6 : Porins
  7.7 : Unknown substrate
8 : DNA metabolism
  8.1 : DNA replication, recombination, and repair
  8.2 : Restriction/modification
  8.3 : Degradation of DNA
  8.4 : Chromosome-associated proteins
9 : Transcription
  9.1 : Degradation of RNA
  9.2 : DNA-dependent RNA polymerase
  9.3 : Transcription factors
  9.4 : RNA processing
10 : Protein synthesis
  10.1 : tRNA aminoacylation
  10.2 : Ribosomal proteins: synthesis and modification
  10.3 : tRNA and rRNA base modification
  10.4 : Translation factors
11 : Protein fate
  11.1 : Protein and peptide secretion and trafficking
  11.2 : Protein modification and repair
  11.3 : Protein folding and stabilization
  11.4 : Degradation of proteins, peptides, and glycopeptides
12 : Regulatory functions
  12.1 : DNA interactions
  12.2 : RNA interactions
  12.3 : Protein interactions
  12.4 : Small molecule interactions
13 : Signal transduction
  13.1 : Two-component systems
  13.2 : PTS
14 : Cell envelope
  14.1 : Surface structures
  14.2 : Biosynthesis and degradation of murein sacculus and peptidoglycan
  14.3 : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
15 : Cellular processes
  15.1 : Cell division
  15.2 : Chemotaxis and motility
  15.3 : Cell adhesion
  15.4 : Conjugation
  15.5 : Detoxification
  15.6 : DNA transformation
  15.7 : Sporulation and germination
  15.8 : Toxin production and resistance
  15.9 : Pathogenesis
  15.10 : Adaptations to atypical conditions
  15.11 : Biosynthesis of natural products
  15.12 : Bioluminescence
16 : Biological processes
  16.1 : Circulate
  16.2 : Construct biomass (Anabolism)
  16.3 : Control
  16.4 : Excrete
  16.5 : Explore
  16.6 : Maintain
  16.7 : Manage energy
  16.8 : Protect
  16.9 : Replicate
  16.10 : Respire
  16.11 : Scavenge (Catabolism)
  16.12 : Sense
  16.13 : Shape
  16.14 : Store
  16.15 : Symbiosis
17 : Mobile and extrachromosomal element functions
  17.1 : Plasmid functions
  17.2 : Prophage functions
  17.3 : Transposon functions
18 : Unknown function
  18.1 : Enzymes of unknown specificity
19 : Unclassified
Roles
Selection is empty.
1 : Metabolism
  1.1 : Carbon compound utilization
   1.1.1 : Carbohydrates/Carbon compounds
    1.1.1.1 : D-allose catabolism
    1.1.1.2 : 2,5-ketogluconate metabolism
    1.1.1.3 : D-arabinose catabolism
    1.1.1.4 : D-galactarate catabolism
    1.1.1.5 : D-galacturonate catabolism
    1.1.1.6 : D-glucarate catabolism
    1.1.1.7 : D-glucuronate catabolism
    1.1.1.8 : L-arabinose catabolism
    1.1.1.9 : L-idonate catabolism
    1.1.1.10 : L-lyxose metabolism
    1.1.1.11 : Fucose catabolism
    1.1.1.12 : Galactitol catabolism
    1.1.1.13 : Galactonate catabolism
    1.1.1.14 : Lactose degradation
    1.1.1.15 : Mannose catabolism
    1.1.1.16 : Rhamnose catabolism
    1.1.1.17 : Sorbitol degradation
    1.1.1.18 : Trehalose degradation, low osmolarity+
    1.1.1.19 : Xylose catabolism
    1.1.1.20 : Glycol degradation
    1.1.1.21 : Mannitol degradation
    1.1.1.22 : Ribose degradation
    1.1.1.23 : Galactose degradation
    1.1.1.24 : Sorbose degradation
    1.1.1.25 : L-ascorbate degradation
   1.1.2 : Fatty acids (fatty acid oxidation)
    1.1.2.1 : Degradation of short-chain fatty acids
    1.1.2.2 : 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation
    1.1.2.3 : Propionate degradation
   1.1.3 : Amino acids
    1.1.3.1 : L-alanine degradation
    1.1.3.2 : L-serine degradation
    1.1.3.3 : Arginine catabolism
    1.1.3.4 : Glutamate degradation
    1.1.3.5 : Glycine cleavage
    1.1.3.6 : Proline utilization
    1.1.3.7 : Threonine catabolism
    1.1.3.8 : Tryptophan utilization
    1.1.3.9 : L-cysteine catabolism
    1.1.3.10 : Lysine cleavage
    1.1.3.11 : Histidine degradation
    1.1.3.12 : Leucine degradation
    1.1.3.13 : Methionine degradation
    1.1.3.14 : Valine degradation
    1.1.3.15 : Phenylalanine, tyrosine degradation
   1.1.4 : Amines
    1.1.4.1 : Phenylethylamine degradation
    1.1.4.2 : Carnitine degradation
    1.1.4.3 : Ornithine degradation
   1.1.5 : Others
    1.1.5.1 : Phenylacetic acid degradation
    1.1.5.2 : Ethanol degradation
    1.1.5.3 : Eugenol catabolism
    1.1.5.4 : Beta-ketoadipate pathway
    1.1.5.5 : Mandelate catabolism
  1.2 : Macromolecule degradation
   1.2.1 : RNA
   1.2.2 : DNA
   1.2.3 : Proteins/peptides/glycopeptides
   1.2.4 : Polysaccharides
    1.2.4.1 : Glycogen catabolism
    1.2.4.2 : Chitin catabolism
  1.3 : Energy metabolism (carbon)
   1.3.1 : Glycolysis
   1.3.2 : Pentose phosphate shunt, oxidative branch
   1.3.3 : Pyruvate dehydrogenase
   1.3.4 : Tricarboxylic acid cycle
   1.3.5 : Fermentation
   1.3.6 : Aerobic respiration
   1.3.7 : Anaerobic respiration
   1.3.8 : ATP proton motive force interconversion
   1.3.9 : Entner-Doudoroff pathway
  1.4 : Energy production/transport
   1.4.1 : Electron donor
   1.4.2 : Electron acceptor
   1.4.3 : Electron carrier
  1.5 : Building block biosynthesis
   1.5.1 : Amino acids
    1.5.1.1 : Glutamate
    1.5.1.2 : Glutamine
    1.5.1.3 : Arginine
    1.5.1.4 : Proline
    1.5.1.5 : Aspartate
    1.5.1.6 : Asparagine
    1.5.1.7 : Lysine, diaminopimelate
    1.5.1.8 : Threonine
    1.5.1.9 : Methionine
    1.5.1.10 : Glycine
    1.5.1.11 : Serine
    1.5.1.12 : Cysteine
    1.5.1.13 : Phenylalanine
    1.5.1.14 : Tyrosine
    1.5.1.15 : Tryptophan
    1.5.1.16 : Histidine
    1.5.1.17 : Alanine
    1.5.1.18 : Isoleucine/valine
    1.5.1.19 : Leucine
    1.5.1.20 : Chorismate
    1.5.1.21 : Homoserine
   1.5.2 : Nucleotide
    1.5.2.1 : Purine biosynthesis
    1.5.2.2 : Pyrimidine biosynthesis
    1.5.2.3 : Purine ribonucleotide biosynthesis
    1.5.2.4 : Pyrimidine ribonucleotide/ribonucleoside biosynthesis
   1.5.3 : Cofactor, small molecule carrier
    1.5.3.1 : Biotin
    1.5.3.2 : Folic acid
    1.5.3.3 : Lipoate
    1.5.3.4 : Molybdenum (molybdopterin)
    1.5.3.5 : Coenzyme A
    1.5.3.6 : Pyridoxine (vitamin B6)
    1.5.3.7 : Nicotinamide adenine dinucleotide (NAD)
    1.5.3.8 : Thiamine (Vitamin B1)
    1.5.3.9 : Riboflavin (Vitamin B2), FAD, FMN
    1.5.3.10 : Glutathione
    1.5.3.11 : Menaquinone (MK), ubiquinone (Q)
    1.5.3.12 : Heme, porphyrin
    1.5.3.13 : Cobalamin (Vitamin B12)
    1.5.3.14 : Enterochelin (enterobactin)
    1.5.3.15 : Chrysobactin
    1.5.3.16 : Achromobactin
    1.5.3.19 : Isoprenoid biosynthesis
    1.5.3.20 : Tetrahydrobiopterin biosynthesis
    1.5.3.21 : Pyochelin biosynthesis
   1.5.4 : Fatty acid and phosphatidic acid
  1.6 : Macromolecules (cellular constituent) biosynthesis
   1.6.1 : Phospholipid
   1.6.2 : Colanic acid (M antigen)
   1.6.3 : Lipopolysaccharide
    1.6.3.1 : O antigen
    1.6.3.2 : Core region
    1.6.3.3 : Lipid A
   1.6.4 : Enterobacterial common antigen (surface glycolipid)
   1.6.5 : K antigen
   1.6.6 : Osmoregulated periplasmic glucan
   1.6.7 : Peptidoglycan (murein)
   1.6.9 : Polysaccharides, cytoplasmic
   1.6.10 : Lipoprotein
   1.6.11 : Glycoprotein
   1.6.12 : Flagella
   1.6.13 : Fimbria, pili, curli
   1.6.15 : Large molecule carriers
    1.6.15.1 : Cytochromes
    1.6.15.2 : Thioredoxin, glutaredoxin
    1.6.15.3 : Biotin carboxyl carrier protein
    1.6.15.4 : Acyl carrier protein
   1.6.16 : Cellulose biosynthesis
  1.7 : Central intermediary metabolism
   1.7.1 : Unassigned reversible reactions
   1.7.2 : Glyoxylate bypass
   1.7.3 : Pentose phosphate shunt, non-oxidative branch
   1.7.6 : Glycerol metabolism
   1.7.7 : Galactose metabolism
   1.7.8 : Gluconeogenesis
   1.7.9 : Misc. glucose metabolism
   1.7.10 : Sugar nucleotide biosynthesis, conversions
   1.7.12 : Amino sugar conversions
   1.7.13 : Amino acid conversion
   1.7.14 : Polyamine biosynthesis
   1.7.15 : 2'-deoxyribonucleotide/ribonucleoside metabolism
   1.7.17 : Formyl-tetrahydrofolate biosynthesis
   1.7.18 : Betaine biosynthesis
   1.7.19 : Incorporation of metal ions
   1.7.20 : S-adenosyl methionine biosynthesis
   1.7.21 : Glyoxylate degradation
   1.7.22 : Carnitine metabolism
   1.7.23 : Methylglyoxal metabolism
   1.7.24 : Cyanate catabolism
   1.7.25 : Glycolate metabolism
   1.7.26 : Allantoin assimilation
   1.7.27 : Pyridoxal 5'-phosphate salvage
   1.7.28 : Pyruvate catabolism
   1.7.29 : Acetate catabolism
   1.7.31 : Aminobutyrate catabolism
   1.7.32 : Putrescine catabolism
   1.7.33 : Nucleotide and nucleoside conversions
   1.7.34 : Peptidoglycan (murein) turnover, recycling
   1.7.35 : Lactate oxidation
   1.7.36 : Trehalose biosynthesis
   1.7.37 : C1 assimilation, serine pathway
   1.7.38 : Methionine salvage pathway
  1.8 : Metabolism of other compounds
   1.8.1 : Phosphorous metabolism
   1.8.2 : Sulfur metabolism
   1.8.3 : Nitrogen metabolism
2 : Information transfer
  2.1 : DNA related
   2.1.1 : DNA replication
   2.1.2 : DNA restriction/modification
   2.1.3 : DNA recombination
   2.1.4 : DNA repair
   2.1.5 : DNA degradation
  2.2 : RNA related
   2.2.2 : Transcription related
   2.2.3 : RNA modification
   2.2.4 : RNA degradation
   2.2.5 : tRNA
   2.2.6 : rRNA, stable RNA
   2.2.7 : Antisense RNA
  2.3 : Protein related
   2.3.1 : Amino acid-activation
   2.3.2 : Translation
   2.3.3 : Posttranslational modification
   2.3.4 : Chaperoning, folding
   2.3.5 : Export, signal peptide cleavage
   2.3.6 : Turnover, degradation
   2.3.7 : Nucleoproteins, basic proteins
   2.3.8 : Ribosomal proteins
   2.3.9 : Non-ribosomal peptide synthetase
3 : Regulation
   3.1. : Type of regulation
   3.1.1 : DNA structure level
    3.1.1.1 : DNA bending, supercoiling, inversion
    3.1.1.2 : Methylation
   3.1.2 : Transcriptional level
    3.1.2.1 : Sigma factors, anti-sigmafactors
    3.1.2.2 : Activator
    3.1.2.3 : Repressor
    3.1.2.4 : Complex regulation
     3.1.2.4.1 : More than one signal needed
     3.1.2.4.2 : Regulons or multilayer component regulatory systems
     3.1.2.4.3 : Two-component regulatory systems (external signal)
     3.1.2.4.4 : Quorum sensing
    3.1.2.5 : Action unknown
   3.1.3 : Posttranscriptional
    3.1.3.1 : Translation attenuation and efficiency
    3.1.3.2 : Covalent modification, demodification, maturation
    3.1.3.3 : Inhibition / activation of enzymes
    3.1.3.4 : Proteases, cleavage of compounds
    3.1.3.5 : Multilayer regulatory systems
    3.1.3.6 : Antisense RNA
   3.1.4 : Regulation level unknown
  3.3 : Genetic unit regulated
   3.3.1 : Operon (regulation of one operon)
   3.3.2 : Regulon (a network of operons encoding related functions)
   3.3.3 : Stimulon (ie. environmental stimulus)
   3.3.4 : Global
  3.4 : Trigger (some information added)
  3.5 : Trigger modulation (some information added)
4 : Transport
  4.1 : Channel-type Transporters
    4.1.A. : alpha-type channels
     4.1.A.1. : The Voltage-gated Ion Channel (VIC) Superfamily
     4.1.A.8. : The Major Intrinsic Protein (MIP) Family
    4.1.A.11 : The Chloride Channel (ClC) Family
    4.1.B.17 : The Outer Membrane Factor (OMF) Family
    4.1.A.22 : The Large Conductance Mechanosensitive Ion Channel (MscL) Family
    4.1.A.23 : The Small Conductance Mechanosensitive Ion Channel (MscS) Family
    4.1.A.46 : The H+- or Na+-translocating Bacterial Flagellar Motor (Mot) Family
   4.1.B : Beta barrel porins (The Outer Membrane Porin (OMP) Functional Superfamily)
    4.1.B.1 : The General Bacterial Porin (GBP) Family
    4.1.B.3 : The Sugar Porin (SP) Family
    4.1.B.9 : The FadL Outer Membrane Protein (FadL) Family
    4.1.B.10 : The Nucleoside-specific Channel-forming Outer Membrane Porin (Tsx) Family
    4.1.B.14 : The Outer Membrane Receptor (OMR) Family
    4.1.B.21 : The OmpG Porin (OmpG) Family
  4.2 : Electrochemical potential driven transporters
    4.2.A. : Porters (Uni-, Sym- and Antiporters)
    4.2.A.1 : The Major Facilitator Superfamily (MFS)
    4.2.A.2 : The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
    4.2.A.3 : The Amino Acid-Polyamine-Choline (APC) Family
    4.2.A.4 : The Cation Diffusion Facilitator (CDF) Family
    4.2.A.6 : The Resistance-Nodulation-Cell Division (RND) Superfamily
    4.2.A.7 : The Drug/Metabolite Transporter (DMT) Superfamily
    4.2.A.8 : The Gluconate:H+ Symporter (GntP) Family
    4.2.A.9 : The Cytochrome oxidase biogenesis (Oxa1) Family
    4.2.A.10 : The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family
    4.2.A.13 : The C4-Dicarboxylate Uptake (Dcu) Family
    4.2.A.14 : The Lactate Permease (LctP) Family
    4.2.A.15 : The Betaine/Carnitine/Choline Transporter (BCCT) Family
    4.2.A.16 : The Telurite-resistance/Dicarboxylate Transporter (TDT) Family
    4.2.A.17 : The Proton-dependent Oligopeptide Transporter (POT) Family
    4.2.A.19 : The Ca2+:Cation Antiporter (CaCA) Family
    4.2.A.20 : The Inorganic Phosphate Transporter (PiT) Family
    4.2.A.21 : The Solute:Sodium Symporter (SSS) Family
    4.2.A.23 : The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
    4.2.A.25 : The Alanine/Glycine:Cation symporter (AGCS) Family
    4.2.A.26 : The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
    4.2.A.27 : The Glutamate:Na+ Symporter (GltS) Family
    4.2.A.33 : The NhaA Na+:H+ Antiporter (NhaA) Family
    4.2.A.34 : The NhaB Na+:H+ Antiporter (NhaB) Family
    4.2.A.36 : The Monovalent Cation:Proton Antiporter-1 (CPA1) Family
    4.2.A.37 : The Monovalent Cation:Proton Antiporter-2 (CPA2) Family
    4.2.A.38 : The K+ Transporter (Trk) Family
    4.2.A.39 : The Nucleobase:Cation Symporter-1 (NCS1) Family
    4.2.A.40 : The Nucleobase:Cation Symporter-2 (NCS2) Family
    4.2.A.41 : The Concentrative Nucleoside Transporter (CNT) Family
    4.2.A.42 : The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
    4.2.A.44 : The Formate-Nitrite Transporter (FNT) Family
    4.2.A.45 : The Metal Ion Transporter (MIT) Family
    4.2.A.47 : The Divalent Anion:Na+ Symporter (DASS) Family
    4.2.A.49 : The Ammonium Transporter (Amt) Family
    4.2.A.53 : The Sulfate Permease (SulP) Family
    4.2.A.55 : The Manganese (Nramp) Fam.
    4.2.A.58 : The Phosphate:Na+ Symporter (PNaS) Family
    4.2.A.61 : The C4-dicarboxylate Uptake C (DcuC) Family
    4.2.A.64 : The Type V Secretory Pathway or Twin Arginine Targeting (Tat) Family
    4.2.A.66 : The Multi Antimicrobial Extrusion (MATE) Family
    4.2.A.68 : The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
    4.2.A.69 : The Auxin Efflux Carrier (AEC) Family
    4.2.A.72 : The K+ uptake permease (KUP) family
    4.2.A.75 : The L-lysine exporter (LysE) family
    4.2.A.76 : The Resistance to Homoserine/Threonine (RhtB) Family
   4.2.C : Ion-gradient driven energizers
    4.2.C.1 : TonB Family of Auxiliary Proteins for Energization of OMR-mediated Transport
  4.3 : Primary Active Transporters
    4.3.A. : Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters
    4.3.A.1 : The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases
     4.3.A.1.a : ATP binding component
     4.3.A.1.m : membrane component
     4.3.A.1.p : periplasmic binding component
     4.3.A.1.am : ATP binding and membrane component
    4.3.A.2 : The H+/Na+-translocating F-, V- and A-type ATPase (F-ATPase) Superfamily
    4.3.A.3 : The P-type ATPase (P-ATPase) Superfamily
    4.3.A.4 : The Arsenite-Antimonite (Ars) Efflux Family
    4.3.A.5 : The Type II (General) Secretory Pathway (IISP) Family
    4.3.A.6 : The Type III (Virulence-related) Secretory Pathway (IIISP) Family
    4.3.A.7 : The Type IV (Conjugal DNA-Protein Transfer) Secretory Pathway (IVSP) Family
    4.3.D. : Oxidoreduction-driven Active Transporters
    4.3.D.1 : The Proton- or sodium ion-translocating NADH Dehydrogenase (NDH) Family
    4.3.D.4 : The Proton-translocating Cytochrome Oxidase (COX) Superfamily
  4.4 : Group Translocators
   4.4.A : Phosphotransferase Systems (PEP-dependent PTS)
    4.4.A.1 : The PTS Glucose-Glucoside (Glc) Family
    4.4.A.2 : The PTS Fructose-Mannitol (Fru) Family
    4.4.A.3 : The PTS Lactose-N,N'-Diacetylchitobiose-betaucoside (Lac) Family
    4.4.A.4 : The PTS Glucitol (Gut) Family
    4.4.A.5 : The PTS Galactitol (Gat) Family
    4.4.A.6 : The PTS Mannose-Fructose-Sorbose (Man) Family
   4.8.A : Accessory Factors Involved in Transport
    4.8.A.1 : The Membrane Fusion Protein (MFP) Family
    4.8.A.2 : The Secretin Auxiliary Lipoprotein (SAL) Family
    4.8.A.3 : MPA1 Family auxillary transport protein
    4.8.A.7 : The Phosphotransferase System Enzyme I (EI) Family
    4.8.A.8 : The Phosphotransferase System HPr (HPr) Family
   4.9.A : Transporters of Unknown Classification
    4.9.A.1 : The Polysaccharide Transporter (PST) Family
    4.9.A.4 : The Nicotinamide Mononucleotide (NMN) Uptake Permease (PnuC) Family
    4.9.A.8 : The Ferrous Iron Uptake (FeoB) Family
    4.9.A.13 : The Short Chain Fatty Acid Transporter (scFAT) Family
    4.9.A.16 : The Septal DNA Translocator (SDT) Family
    4.9.A.17 : The Metal Ion Transporter (MIT) Family
   4.9.B : Putative uncharacterized transport protein
    4.9.B.3 : The Putative Bacterial Murein Precursor Exporter (MPE) Family
    4.9.B.4 : The Putative Efflux Transporter (PET) Family
    4.9.B.6 : The Toxic Hok/Gef Protein (Hok/Gef) Family
    4.9.B.10 : The 6TMS Putative MarC Transporter (MarC) Family
    4.9.B.18 : The SecDF-associated Single Transmembrane Protein (SSTP) Family
    4.9.B.21 : The Frataxin (Frataxin) Family
    4.9.B.22 : The Putative Permease (PerM) Family
    4.9.B.24 : The Testis-Enhanced Gene Transfer (TEGT) Family
    4.9.B.25 : The YbbM (YbbM) Family
    4.9.B.27 : The YdjX-Z (YdjX-Z) Family
    4.9.B.28 : The YqaE (YqaE) Family
    4.9.B.29 : The YebN (YebN) Family
    4.9.B.31 : The YqiH (YqiH) Family
    4.9.B.32 : The Putative Vectorial Glycosyl Polymerization (VGP) Family
  4.S : substrate
   4.S.1 : (D)-glucarate/galactarate
   4.S.10 : allose/ribose
   4.S.100 : L-arabinose
   4.S.101 : L-arabinose /H+
   4.S.102 : L-arabinose/ isopropyl-beta-D-thiogalactopyranoside
   4.S.103 : L-asparagine
   4.S.104 : lipooligosaccharides
   4.S.105 : lipopolysaccharide
   4.S.106 : lipoprotein
   4.S.107 : L-lactate
   4.S.108 : L-leucine/L-valine/L-iso-leucine
   4.S.109 : L-rhamnose/H+
   4.S.11 : alpha-ketoglutarate
   4.S.110 : L-threonine/L-serine
   4.S.111 : lysine
   4.S.112 : lysine/arginine/ornithine
   4.S.113 : maltose
   4.S.114 : maltose/maltodextrin
   4.S.115 : mannitol
   4.S.116 : mannose
   4.S.117 : mellobiose
   4.S.118 : methionine
   4.S.119 : methylgalactoside/galactose
   4.S.12 : amino acid
   4.S.120 : Mg++
   4.S.121 : Mg2+/Ni2+/Co2+
   4.S.122 : microcin B17
   4.S.123 : Mn+/H+
   4.S.124 : molybdate
   4.S.125 : molybdenum
   4.S.126 : multidrug
   4.S.127 : multidrug/bicyclomycin
   4.S.128 : muropeptide
   4.S.129 : myo-inositor
   4.S.13 : amino acid/amide
   4.S.130 : Na+
   4.S.131 : Na+/ alanine/glycine
   4.S.132 : Na+/ H+
   4.S.133 : Na+/Ca+
   4.S.134 : Na+/dicarboxylate
   4.S.135 : Na+/glutamate/aspartate
   4.S.136 : Na+/H+
   4.S.137 : Na+/leucine/valine/iso-leucine
   4.S.138 : Na+/pantothenate
   4.S.139 : Na+/proline
   4.S.14 : ammonium
   4.S.140 : Na+/serine/threonine
   4.S.141 : N-acetylgalactosamine
   4.S.142 : N-acetylglucosamine
   4.S.143 : Ni++
   4.S.144 : nicotinamide mononucleotide
   4.S.145 : nitrite
   4.S.146 : nucleoside
   4.S.147 : nucleoside/H+
   4.S.148 : oligopeptide
   4.S.149 : oligopeptides
   4.S.15 : antibiotic
   4.S.150 : p-aminobenzoyl-glutamate
   4.S.151 : Pb/Cd/Zn/Hg
   4.S.152 : peptide
   4.S.153 : phenylalanine
   4.S.154 : phenylalanine/ tyrosine
   4.S.155 : phosphate
   4.S.156 : polymyxin
   4.S.157 : potassium
   4.S.158 : proline
   4.S.159 : proline/betaine
   4.S.16 : arabinose polymer
   4.S.160 : protein
   4.S.161 : protein/DNA
   4.S.162 : purine/xanthine
   4.S.163 : putrescine
   4.S.164 : putrescine/ornithine
   4.S.165 : putrescine/ornitine
   4.S.166 : putrescine/spermidine
   4.S.167 : serine
   4.S.168 : shikimate/dehydroshikimate
   4.S.169 : sialic acid
   4.S.17 : arginine
   4.S.170 : S-methylmethionine
   4.S.171 : spermidine/putrescine
   4.S.172 : sucrose
   4.S.173 : sugar
   4.S.174 : sulfate
   4.S.175 : taurine
   4.S.176 : tellurite
   4.S.177 : thiamine
   4.S.178 : thiosulfate
   4.S.179 : thiosulfate/sulfate
   4.S.18 : arginine/ornitine
   4.S.180 : threonine
   4.S.181 : trehalose
   4.S.182 : tripeptide
   4.S.183 : tryptophan
   4.S.184 : tyrosine
   4.S.185 : uracil
   4.S.186 : urasil
   4.S.187 : vitamin B12
   4.S.188 : water
   4.S.189 : xanthosine
   4.S.19 : arsenite
   4.S.190 : xylose/H+
   4.S.191 : Zn
   4.S.192 : chrysobactin
   4.S.193 : achromobactin
   4.S.2 : 2-keto-3-deoxy-D-gluconate
   4.S.20 : benzoate
   4.S.21 : beta-galactosidase/lactose and glucose
   4.S.22 : beta-glucoside
   4.S.23 : betaine/choline/glycine
   4.S.24 : betaine/choline/glycine transport protein
   4.S.25 : Ca+/ H+
   4.S.26 : cadaverine/lysine
   4.S.27 : carnitine
   4.S.28 : cation
   4.S.29 : cellobiose/arbutin/salicin
   4.S.3 : 3-hydroxyphenylpropionic acid
   4.S.30 : cellobiose/salicin/arbutin
   4.S.31 : chloramphenicol
   4.S.32 : chloride
   4.S.33 : choline
   4.S.34 : citrate/succinate
   4.S.35 : colicin4
   4.S.36 : Cu
   4.S.37 : curli subunit
   4.S.38 : cyanate
   4.S.39 : cysteine
   4.S.4 : 3-phenylpropionic acid
   4.S.40 : cysteine/O-acetyl-L-serine/cysteine metabolites
   4.S.41 : cytosine
   4.S.42 : D-alanine/D-serine/glycine
   4.S.43 : D-galactonate
   4.S.44 : D-glucarate
   4.S.45 : D-glucose/trehalose
   4.S.46 : dicarboxylate
   4.S.47 : dipeptide
   4.S.48 : D-ribose
   4.S.49 : drug
   4.S.5 : alkanesulfonate
   4.S.50 : D-xylose
   4.S.51 : enterochelin
   4.S.52 : fatty acid
   4.S.53 : Fe
   4.S.54 : Fe++
   4.S.55 : ferric dicitrate
   4.S.56 : ferric enterobactin
   4.S.57 : ferric hydroxamate
   4.S.58 : ferrichrome
   4.S.59 : formate
   4.S.6 : alkanesulphonate
   4.S.60 : formate/oxalate
   4.S.61 : fosfidomycin/H+
   4.S.62 : frucose
   4.S.63 : fructose
   4.S.64 : fucose
   4.S.65 : galactitol
   4.S.66 : galactose/H+
   4.S.67 : gamma-aminobutyrate
   4.S.68 : glucitol/sorbitol
   4.S.69 : gluconate
   4.S.7 : alklphosphonate
   4.S.70 : gluconate/L-idonate
   4.S.71 : glucose
   4.S.72 : glucose/maltose
   4.S.73 : glucuronide
   4.S.74 : glutamate/aminobutyric acid
   4.S.75 : glutamate/aspartate
   4.S.76 : glutamine
   4.S.77 : glycerol
   4.S.78 : glycerol-3-P
   4.S.79 : glycine betaine choline transport
   4.S.8 : alkylphosphonate
   4.S.80 : glycine/betaine/proline
   4.S.81 : group A colicins
   4.S.82 : H+
   4.S.83 : H+/acridine
   4.S.84 : H+/lactose/glucose
   4.S.85 : heme
   4.S.86 : hexose phosphate
   4.S.87 : hexuronate
   4.S.88 : histidine
   4.S.89 : histidine/lysine/arginine/ornithine
   4.S.9 : allantoin/ion
   4.S.90 : homoserine/lactone
   4.S.91 : hydrophilic molecule
   4.S.92 : hydrophilic molecules
   4.S.93 : ion
   4.S.94 : ions
   4.S.95 : iron dicitrate
   4.S.96 : K+
   4.S.97 : K+/H+
   4.S.98 : lactate
   4.S.99 : lactose
5 : Cell processes
  5.1 : Cell division
  5.2 : Cell cycle physiology
  5.3 : Motility (incl. chemotaxis, energytaxis, aerotaxis, redoxtaxis)
  5.4 : Genetic exchange, recombination
  5.5 : Adaptation to stress
   5.5.1 : Osmotic pressure
   5.5.2 : Temperature extremes
   5.5.3 : Starvation response
   5.5.4 : pH response
   5.5.5 : Dessication
   5.5.6 : Other stresses (mechanical, nutritional, oxidative)
   5.5.7 : Fe aquisition
  5.6 : Protection
   5.6.1 : Radiation
   5.6.2 : Detoxification (xenobiotic metabolism)
   5.6.3 : Cell killing
   5.6.4 : Drug resistance/sensitivity
  5.8 : SOS response
  5.10 : Defense/survival
  5.11 : DNA uptake
  5.12 : Biofilm production
  5.13 : Virulence associated
6 : Cell structure
  6.1 : Membrane
  6.2 : Peptidoglycan (murein)
  6.3 : Surface antigens (ECA, O antigen of LPS)
  6.4 : Flagellum
  6.5 : Pilus
  6.6 : Ribosome
  6.7 : Capsule (M and K antigens)
7 : Location of gene products
  7.1 : Cytoplasm
  7.2 : Periplasmic space
  7.3 : Inner membrane
  7.4 : Outer membrane
  7.5 : Extracellular
8 : extrachromosomal
  8.1 : Prophage genes and phage related functions
   8.1.1 : DNA packaging, phage assembly
   8.1.2 : Replication
   8.1.3 : Regulation
   8.1.4 : Integration, recombination
   8.1.5 : Lysis
   8.1.6 : Structural component
  8.2 : Plasmid related
   8.2.1 : replication and maintenance
   8.2.2 : plasmid transfer
  8.3 : Transposon related
   8.3.1 : transposases
   8.3.2 : regulation of mobility
  8.4 : Colicin related
9 : DNA sites
10 : cryptic genes
PubMedId
Note
Additional Data
Comment
Interaction
Phenotype
SMILES
Internal comment
Selection is empty.
DBxref
PDB
PubChem
ChEMBL
ChEBI
DOI
Selection is empty.
Class
1a : Function from experimental evidences in the studied strain
1b : Function from experimental evidences in the studied species
1c : Function from experimental evidences in the studied genus
2a : Function from experimental evidences in other organisms
2b : Function from indirect experimental evidences (e.g. phenotypes)
3 : Putative function from multiple computational evidences
4 : Unknown function but conserved in other organisms
5 : Unknown function