Genomic Tools

OG ID	OG function	Label	Gene	Product	COG	PFAM short name	KO
3NJUG	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	ACIAD0021	lspA	prolipoprotein signal peptidase (Signal peptidase II.)	COG0597	Peptidase_A8	K03101
3NJ27	peptidyl-prolyl cis-trans isomerase	ACIAD0065	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans isomerase (rotamase)	COG0545	FKBP_C, FKBP_N	K03773
3NJF4	Polysaccharide biosynthesis/export protein	ACIAD0070	wza	polysaccharide export protein	COG1596	Poly_export, SLBB	K01991
3NJSX	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ACIAD0072	ugd	UDP-glucose 6-dehydrogenase	COG1004	UDPG_MGDP_dh, UDPG_MGDP_dh_C, UDPG_MGDP_dh_N	K00012
1SA3F	glycosyl transferase family 2	ACIAD0074		putative glycosyl transferase family 2		Glycos_transf_2
3NIR1	RmlD substrate binding domain	ACIAD0076	rmlB	dTDP-D-glucose-4,6-dehydratase	COG1088	GDP_Man_Dehyd	K01710
3NM08	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	ACIAD0078	rmlD	dTDP-4-dehydrorhamnose reductase (dTDP-4-keto-L- rhamnose reductase) (dTDP-6-deoxy-L-mannose dehydrogenase) (dTDP-L- rhamnose synthetase)	COG1091	RmlD_sub_bind	K00067
3NJY8	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	ACIAD0079	rmlA	dTDP-glucose pyrophosphorylase (glucose-1-phosphate thymidylyltransferase)	COG1209	NTP_transferase	K00973
3NJVJ	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	ACIAD0080	rmlC	dTDP-4-keto-6-deoxy-D-glucose-3,5-epimerase	COG1898	dTDP_sugar_isom	K01790
1STQD	Glycosyl transferases group 1	ACIAD0081		putative glycosyl transferase family 1		Glycos_transf_1
3NQM1	Glycosyltransferase like family 2	ACIAD0082		putative glycosyl transferase family 2 (rhamnosyl transferase)	COG1216	Glycos_transf_2	K07011
3NPSW	Glycosyl transferases group 1	ACIAD0084		putative glycosyl transferase family 1 (mannosyl transferase)		Glyco_transf_4, Glycos_transf_1
3NMRW	Belongs to the mannose-6-phosphate isomerase type 2 family	ACIAD0086	epsM	bifunctional protein [Includes: Mannose-6-phosphate isomerase (Phosphomannose isomerase) (Pmi) (Phosphohexomutase); Mannose-1-phosphate guanylyl transferase (Gdp) (GDP-mannose pyrophosphorylase) (Gmp)]	COG0662, COG0836	MannoseP_isomer, NTP_transferase	K16011
3NIGZ	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ACIAD0087		putative UDP-glucose/GDP-mannose dehydrogenase	COG0677	UDPG_MGDP_dh, UDPG_MGDP_dh_C, UDPG_MGDP_dh_N	K02474
3NK1T	3-beta hydroxysteroid dehydrogenase/isomerase family	ACIAD0088		putative NAD-dependent epimerase/dehydratase (WbpP)		Epimerase	K02473
3NMJE	Glycosyltransferase Family 4	ACIAD0090		putative glycosyl transferase family 1		Glyco_transf_4, Glycos_transf_1
3NKJC	Glycosyltransferase Family 4	ACIAD0091		putative glycosyl transferase family 1		Glyco_trans_1_4, Glyco_transf_4
3NMAJ	Glycosyl transferases group 1	ACIAD0092		putative glycosyl transferase family 1		Glyco_trans_1_4, Glyco_trans_4_2
3NKCB	Bacterial sugar transferase	ACIAD0093		putative UDP-galactose phosphate transferase (WeeH)		Bac_transf
3NIY7	RmlD substrate binding domain	ACIAD0096		putative dTDP-glucose-4,6-dehydratase/UDP-glucose 4-epimerase (WeeK) (WbpM)		CoA_binding_3, Polysacc_synt_2
3NKCB	Bacterial sugar transferase	ACIAD0098		putative UDP-glucose lipid carrier transferase/glucose-1-phosphate transferase in colanic acid gene cluster (WcaJ)	COG2148	Bac_transf, CoA_binding_3	K03606
3NKR1	UTP-glucose-1-phosphate uridylyltransferase	ACIAD0099	galU	UTP-glucose-1-phosphate uridylyltransferase	COG1210	NTP_transferase	K00963
3NJGE	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ACIAD0100		putative UDP-glucose 6-dehydrogenase (Ugd) (Udg)	COG1004	UDPG_MGDP_dh, UDPG_MGDP_dh_C	K00012
3NII4	UDP-glucose 4-epimerase	ACIAD0102	galE	UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase)	COG1087	Epimerase	K01784
3NIXG	macromolecule glycosylation	ACIAD0103	pglL	O-oligosaccharyltransferase		PglL_A, Wzy_C, Wzy_C_2
3NNNM	Pili assembly chaperone PapD, C-terminal domain	ACIAD0123		putative pili assembly chaperone		PapD_C, PapD_N
3NIFI	Belongs to the DapA family	ACIAD0130	kdgD	5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy- glucarate dehydratase)	COG0329	DHDPS	K01707
1T2BF	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	ACIAD0139		putative outer membrane protein
3NMQ7	Lysin motif	ACIAD0168		LysM domain-containing protein		Hydrolase_2, LysM
3NIWK	TonB dependent receptor	ACIAD0214		putative outer membrane copper receptor (OprC)	COG1629	Plug, TonB_dep_Rec	K02014
3NIEB	Glycosyl hydrolases family 25	ACIAD0226		putative lysozyme	COG3757	Glyco_hydro_25	K07273
3NJR0	tail specific protease	ACIAD0257		putative periplasmic carboxyl-terminal protease	COG0793	Peptidase_S41	K03797
3NK5B	Belongs to the peptidase S11 family	ACIAD0262	pbpG	D-alanyl-D-alanine endopeptidase, penicillin-binding protein 7 and penicillin-binding protein 8	COG1686	Peptidase_S11	K07262
3NKJJ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	ACIAD0270	murD	UDP-N-acetylmuramoylalanine-D-glutamate ligase	COG0771	Mur_ligase_C, Mur_ligase_M	K01925
3NJQ1	Outer membrane efflux protein	ACIAD0278	tolC	channel-tunnel spanning the outer membrane and periplasm segregation of daughter chromosomes	COG1538	OEP	K12340
3NJEZ	OmpW family	ACIAD0314		putative outer membrane protein W	COG3047	OmpW	K07275
3NMUN	Asp/Glu/Hydantoin racemase	ACIAD0318	racD	D-aspartate racemase	COG1794	Asp_Glu_race	K01779
3NNFJ	COG3209 Rhs family protein	ACIAD0339		conserved hypothetical protein
3NJE9	Pili assembly chaperone PapD, C-terminal domain	ACIAD0388	acuD	fimbrial chaperone AcuD	COG3121	PapD_C, PapD_N	K07346
3NIIR	Transfers the fatty acyl group on membrane lipoproteins	ACIAD0415	lnt	apolipoprotein N-acyltransferase, copper homeostasis protein	COG0815	CN_hydrolase	K03820
3NJCZ	Glycosyl transferase 4-like domain	ACIAD0482		putative glycosyltransferase		Glyco_transf_4, Glycos_transf_1
3NJM6	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	ACIAD0484	lpxP	Lipid A biosynthesis (KDO) 2-(lauroyl)-lipid IVA acyltransferase (Heat shock protein B)	COG1560	Lip_A_acyltrans	K02517
3NIUX	Gamma-glutamyltranspeptidase	ACIAD0485		putative gamma-glutamyltranspeptidase	COG0405	G_glu_transpept	K00681
3NM4S	Gram-negative bacterial TonB protein C-terminal	ACIAD0507		putative TonB	COG0810	TonB_C	K03832
3NJV6	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	ACIAD0518	lgt	prolipoprotein diacylglyceryl transferase	COG0682	LGT	K13292
3NK7I	Belongs to the peptidase S41A family	ACIAD0552	prc	carboxy-terminal protease for penicillin-binding protein	COG0793	DUF3340, PDZ, Peptidase_S41	K03797
3NJVX	Glycosyltransferase Family 4	ACIAD0553		putative glycosyl transferase		Glyco_transf_4, Glycos_transf_1
3NIR2	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	ACIAD0564		conserved hypothetical protein; putative PQQ enzyme repeat domain protein	COG1520	PQQ_2, PQQ_3	K17713
3NM7H	Glycosyl transferase family 2	ACIAD0572		putative glycosyl transferase (GT2 family)		Glycos_transf_2
3NIJE	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	ACIAD0576		conserved hypothetical protein		LolA
3NM2D	Mitochondrial fission ELM1	ACIAD0598		conserved hypothetical protein	COG3660	Mito_fiss_Elm1	K07276
3NK6S	COG0463 Glycosyltransferases involved in cell wall biogenesis	ACIAD0601		putative lipopolysaccharide core biosynthesis glycosyl transferase LpsC		Glycos_transf_2
3NKPC	Glycosyl transferases group 1	ACIAD0602		putative glycosyltransferase		Glyco_transf_4, Glycos_transf_1
3NTK6	Glycosyltransferase family 25 (LPS biosynthesis protein)	ACIAD0604		putative glycosyltransferase involved in LPS biosynthesis		Glyco_transf_25
3NIQJ	Sporulation related domain	ACIAD0645		conserved hypothetical protein		SPOR
3NJ7Z	Belongs to the ompA family	ACIAD0653		putative lipoprotein precursor		OmpA
3NIUB	Belongs to the EPSP synthase family. MurA subfamily	ACIAD0660	murA	UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT)	COG0766	EPSP_synthase	K00790
3NJM8	Belongs to the ompA family	ACIAD0697		putative Outer membrane protein precursor (OmpA-like)	COG2885	OMP_b-brl, OmpA	K03286
3NN59	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	ACIAD0704	mscL	mechanosensitive channel	COG1970	MscL	K03282
3NIMC	Conserved TM helix	ACIAD0750		conserved hypothetical protein; putative membrane protein		TM_helix
3NIVF	Nucleoside-specific channel-forming protein, Tsx	ACIAD0769	tsx	nucleoside-specific channel-forming protein	COG3248	Channel_Tsx	K05517
3NN73	Membrane	ACIAD0770		conserved hypothetical protein
3NM18	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ACIAD0784	nolF	nodulation protein		HlyD_3
3NJPV	Involved in formation and maintenance of cell shape	ACIAD0826	mreC	rod shape-determining protein	COG1792	MreC	K03570
3NN3U	rod shape-determining protein MreD	ACIAD0828	mreD	rod shape-determining protein	COG2891	MreD	K03571
3NIVW	NmrA-like family	ACIAD0849		putative dehydrogenase		Epimerase
3NIW7	Belongs to the ompA family	ACIAD0898		putative outer membrane protein		OmpA
3NT6T	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	ACIAD0909	smpA	outer membrane lipoprotein	COG2913	SmpA_OmlA	K06186
3NIUX	Gamma-glutamyltranspeptidase	ACIAD0929	ggt	gamma-glutamyltranspeptidase precursor	COG0405	G_glu_transpept	K00681
1SI2C	COG3209 Rhs family protein	ACIAD0943		conserved hypothetical protein
3NIKZ	Belongs to the BCCT transporter (TC 2.A.15) family	ACIAD1012	betT2	high-affinity choline transporter (BCCT family)	COG1292	BCCT	K02168
3NJ8M	Glycosyl transferase family 21	ACIAD1030		putative transport protein (VGP family) (Haemin storage system) (HmsR)	COG1215	Glyco_tranf_2_3	K11936
3NIFT	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	ACIAD1061	mtgA	monofunctional biosynthetic peptidoglycan transglycosylase	COG0744	Transgly	K03814
3NT02	RHS Repeat	ACIAD1078		putative RHS-related protein		RHS_repeat
3NNDC	NlpE N-terminal domain	ACIAD1085		putative lipoprotein		NlpE
3NJ50	Belongs to the transpeptidase family. MrdA subfamily	ACIAD1101	pbpA	penicillin-binding protein 2	COG0768	PBP_dimer, Transpeptidase	K05515
3NJBH	Dolichyl-phosphate-mannose-protein mannosyltransferase	ACIAD1117		putative membrane glycosyltransferase (GT83 family)		PMT_2
3NJ1D	Glycosyltransferase like family 2	ACIAD1119		putative bactoprenol glycosyl transferase, phage origin	COG0463	Glycos_transf_2	K20534
3NKSP	LppC putative lipoprotein	ACIAD1131		conserved hypothetical protein; putative signal peptide	COG3107	LppC	K07121
3NJAK	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	ACIAD1138		bifunctional protein [Includes: lytic murein transglycosylase C, membrane-bound (MtlD); putative cell wall hydrolase]		LysM, SLT
3NJIY	Barrel-sandwich domain of CusB or HlyD membrane-fusion	ACIAD1157		putative RND transporter, membrane fusion protein	COG0845	HlyD_D23	K07799
3NJKG	Outer membrane efflux protein	ACIAD1160		putative membrane channel protein		OEP
3NJE2	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	ACIAD1175	wecB	UDP-N-acetyl glucosamine-2-epimerase	COG0381	Epimerase_2	K01791
3NT04	Glycosyl transferase family 21	ACIAD1178		putative glycosyltransferase		Glyco_tranf_2_3
3NIWC	Belongs to the peptidase S11 family	ACIAD1184		putative D-ala-D-ala-carboxypeptidase, penicillin-binding protein	COG1686	Peptidase_S11	K07258
3NIQN	OmpW family	ACIAD1199		putative outer membrane W signal peptide protein	COG3047	OmpW	K07275
3NK5A	Belongs to the peptidase S11 family	ACIAD1225	dacC	D-ala-D-ala-carboxypeptidase; penicillin-binding protein 5 (precursor)	COG1686	PBP5_C, Peptidase_S11	K07258
3NK2K	Peptidase family M23	ACIAD1229	nlpD	lipoprotein precursor	COG0739	LysM, Peptidase_M23	K06194
3NK04	Peptidase family M48	ACIAD1260		conserved hypothetical protein; putative Zn-dependent protease with chaperone function		Peptidase_M48
3NJDC	Phospholipase	ACIAD1354		putative phospholipase A1 precursor (PldA)	COG2829	PLA1	K01058
3NJ00	zinc metalloprotease	ACIAD1377		putative membrane-associated Zn-dependent proteases 1	COG0750	PDZ_2, Peptidase_M50	K11749
3NJMK	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	ACIAD1378		putative outer membrane protein	COG4775	Bac_surface_Ag, POTRA	K07277
3NJVP	Outer membrane protein (OmpH-like)	ACIAD1379		putative outer membrane protein (OmpH)	COG2825	OmpH	K06142
3NJ49	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	ACIAD1380	lpxD	UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase	COG1044	Hexapep, Hexapep_2, LpxD	K02536
3NJGX	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	ACIAD1382	lpxA	UDP-acetylglucosamine acyltransferase	COG1043	Acetyltransf_11, Hexapep	K00677
3NKKX	Nucleoside-diphosphate-sugar epimerases	ACIAD1390		conserved hypothetical protein		Semialdhyde_dh
3NKGZ	Gram-negative bacterial TonB protein C-terminal	ACIAD1477		conserved hypothetical protein; putative TonB-related protein		TonB_C
3NJ4R	Arabinose 5-phosphate isomerase	ACIAD1482	kdsD	D-arabinose 5-phosphate isomerase	COG0517, COG0794	CBS, SIS	K06041
3NJQY	Outer membrane efflux protein	ACIAD1487		putative outer membrane efflux protein, type I secretion protein	COG1538	OEP	K12543
3NKF2	HlyD membrane-fusion protein of T1SS	ACIAD1489		putative protein secretion efflux system, membrane fusion protein (hemolysin-type secretion transmembrane protein) (superfamily ABC, membrane)	COG0845	Biotin_lipoyl_2, HlyD_3	K12542
3NT4I	Gram-negative bacterial TonB protein C-terminal	ACIAD1528		putative tonB-like protein	COG0810	TonB_C	K03832
3NN7N	Glycosyl transferase family 2	ACIAD1558		putative glycosyl transferase (GT2 family)		Glycos_transf_2
3NT4J	Gram-negative bacterial TonB protein C-terminal	ACIAD1588		putative tonB-like protein	COG0810	TonB_C	K03832
3NSQQ	Lipocalin-like domain	ACIAD1626		putative outer membrane lipoprotein (lipocalin)	COG3040	Lipocalin_2	K03098
3NJM9	Mycolic acid cyclopropane synthetase	ACIAD1630	cfa	cyclopropane-fatty-acyl-phospholipid synthase	COG2230	CMAS	K00574
3NKMF	Mycolic acid cyclopropane synthetase	ACIAD1632		putative cyclopropane-fatty-acyl-phospholipid synthase	COG2230	CMAS	K00574
3NIRJ	Acetyltransferase (GNAT) domain	ACIAD1637		antibiotic resistance protein (acepita)	COG1247	Acetyltransf_4	K03823
3NJT9	SmpA / OmlA family	ACIAD1640		putative antigen		OmpA, SmpA_OmlA
3NMGF	Transglycosylase SLT domain	ACIAD1663		conserved hypothetical protein		SLT
3NSMF	LrgB-like family	ACIAD1673		conserved hypothetical protein; putative membrane protein		LrgB
3NKF0	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	ACIAD1697	dcaP	porin precurseur in catabolism of dicarboxylic acids		Sugarporin_N
3NK6E	Carbohydrate-selective porin, OprB family	ACIAD1715	quiX	porin	COG3659	OprB	K07267
3NJEP	Mechanosensitive ion channel	ACIAD1869		putative transporter with mechanosensitive ion channel.	COG0668	MS_channel	K16053
3NJJM	RmlD substrate binding domain	ACIAD1891		putative UDP-galactose 4-epimerase (GalE-like)	COG1087	Epimerase	K01784
3NJ3H	Cell wall formation	ACIAD1945	murB	UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding	COG0812	FAD_binding_4, MurB_C	K00075
3NIHT	Belongs to the KdsA family	ACIAD2002	kdsA	2-dehydro-3-deoxyphosphooctonate aldolase	COG2877	DAHP_synth_1	K01627
3NJE7	Linear amide C-N hydrolases, choloylglycine hydrolase family	ACIAD2026		putative choloylglycine hydrolase protein	COG3049	CBAH	K01442
3NN30	NlpC/P60 family	ACIAD2149		putative cell wall-associated hydrolases (invasion-associated proteins)		NLPC_P60
3NJFY	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	ACIAD2234	mrcB	bifunctional protein [Includes penicillin-insensitive transglycosylase; penicillin-sensitive transpeptidase] (penicillin-binding protein 1B)	COG0744	Transgly, Transpeptidase, UB2H	K05365
1MWUN	Outer membrane protein (Porin)	ACIAD2246		putative outer membrane porin protein precursor		Porin_4
3NJBT	Peptidoglycan polymerase that is essential for cell wall elongation	ACIAD2263	rodA	rod shape-determining protein	COG0772	FTSW_RODA_SPOVE	K05837
3NKMR	Transglycosylase SLT domain	ACIAD2264	mltB	membrane-bound lytic murein transglycosylase B	COG2951	SLT_2	K08305
3NJEK	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	ACIAD2265		putative rare lipoprotein A family (RlpA-like)	COG0797	DPBB_1	K03642
3NIQN	OmpW family	ACIAD2272		conserved hypothetical protein; putative outer membrane protein		OmpW
3NJDS	Gram-negative porin	ACIAD2319		putative porin precursor		Porin_4
3NKDW	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	ACIAD2324	lpxB	lipid A-disaccharide synthase	COG0763	LpxB	K00748
3NK83	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	ACIAD2362	kdsB	3-deoxy-manno-octulosonate cytidylyltransferase	COG1212	CTP_transf_3	K00979
3NJHV	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	ACIAD2363	lpxK	tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase)	COG1663	LpxK	K00912
3NJ0U	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	ACIAD2369		putative nucleotidyl transferase	COG1208	NTP_transferase	K00992
3NJSZ	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	ACIAD2371	ostA	organic solvent tolerance protein precursor or increased membrane permeability protein	COG1452	OstA, OstA_C	K04744
3NIEI	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	ACIAD2372	surA	peptidyl-prolyl cis-trans isomerase	COG0760	Rotamase, Rotamase_3, SurA_N	K03771
3NII7	TamB, inner membrane protein subunit of TAM complex	ACIAD2402		conserved hypothetical protein	COG2911	TamB	K09800
3NIV8	Surface antigen	ACIAD2403		conserved hypothetical protein; putative outer membrane protein	COG0729	Bac_surface_Ag, POTRA_TamA_1	K07278
3NJY7	ErfK YbiS YcfS YnhG family protein	ACIAD2475		conserved hypothetical protein; putative signal peptide		PG_binding_1, YkuD
3NM4V	Lipocalin-like domain	ACIAD2568		putative outer membrane lipoprotein	COG3040	Lipocalin_2	K03098
3NK8H	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	ACIAD2584	lepA	GTP-binding protein	COG0481	EFG_C, GTP_EFTU, GTP_EFTU_D2, LepA_C	K03596
3NKQS	TonB C terminal	ACIAD2621	tolA	tolerance to group A colicins, single-stranded filamentous DNA phage, required for OM integrity	COG3064	Fibrinogen_BP, TonB_2	K03646
3NKBN	Belongs to the ompA family	ACIAD2623	pal	peptidoglycan-associated lipoprotein precursor	COG2885	OmpA	K03640
3NIFD	Bacterial lipid A biosynthesis acyltransferase	ACIAD2638		putative lipid A biosynthesis lauroyl acyltransferase	COG1560	Lip_A_acyltrans	K02517
3NIGK	MacB-like periplasmic core domain	ACIAD2641	lolC	transport protein of outer membrane lipoproteins (ABC superfamily, membrane)	COG4591	FtsX, MacB_PCD	K09808
3NIK7	Outer membrane efflux protein	ACIAD2648		conserved hypothetical protein; putative outer membrane efflux protein		OEP
3NK8Q	OmpA family	ACIAD2682		putative outer membrane lipoprotein	COG2885	OmpA	K03286
3NIZ9	D-alanyl-D-alanine carboxypeptidase	ACIAD2699		conserved hypothetical protein; putative membrane protein	COG5632	Peptidase_M15_4	K17733
COG3209	self proteolysis	ACIAD2704		conserved hypothetical protein
COG3209	self proteolysis	ACIAD2704		conserved hypothetical protein
3NT02	RHS Repeat	ACIAD2709		hypothetical protein		RHS_repeat
3NJV2	COG3209 Rhs family protein	ACIAD2710		hypothetical protein
3NK4E	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	ACIAD2824		conserved hypothetical protein; putative protein (DcaP-like)
3NISE	Transglycosylase SLT domain	ACIAD2827		putative periplasmic binding protein of transport/transglycosylase		SLT
3NJTE	Transglycosylase SLT domain	ACIAD2832		putative transglycosylase		SLT
3NNIC	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	ACIAD2837	dgkA	diacylglycerol kinase	COG0818	DAGK_prokar	K00901
3NJGY	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	ACIAD2898		putative competence protein (ComL)	COG4105	TPR_18	K05807
3NJDU	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	ACIAD2902	lolB	outer-membrane lipoprotein precursor	COG3017	LolB	K02494
3NNP5	Acetyltransferase (GNAT) family	ACIAD2918		putative acyltransferase		Acetyltransf_1
3NKC7	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	ACIAD2937	lolA	outer-membrane lipoproteins carrier protein	COG2834	LolA	K03634
3NJZ0	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ACIAD2943		putative RND multidrug efflux membrane fusion protein MexA precursor	COG0845	HlyD_D23	K03585
3NJR2	Outer membrane efflux protein	ACIAD2945		putative outer membrane protein oprM precursor	COG1538	OEP	K18139
3NJ0T	Carbohydrate-selective porin, OprB family	ACIAD2984		putative glucose-sensitive porin (OprB-like )	COG3659	OprB	K07267
3NIKB	LrgB-like family	ACIAD3007		conserved hypothetical protein; putative membrane protein		LrgB
3NK9B	MlaA lipoprotein	ACIAD3018		putative lipoprotein precursor (VacJ) transmembrane	COG2853	MlaA	K04754
3NIPP	Mechanosensitive ion channel	ACIAD3026		putative small conductance mechanosensitive ion channel		MS_channel
3NMVT	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	ACIAD3049		putative TonB_C domain-containing protein		TonB_2
3NMK0	COG3209 Rhs family protein	ACIAD3087		conserved hypothetical protein
3NKK6	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	ACIAD3107		putative minor lipoprotein	COG2980		K03643
3NJBY	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ACIAD3109		putative secretion protein (HlyD family)	COG0845	HlyD_D23	K13888
3NIGG	Outer membrane efflux protein	ACIAD3111		putative outer membrane protein precursor		OEP
3NMTU	chlorophyll binding	ACIAD3114		conserved hypothetical protein
3NJXX	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	ACIAD3157		putative lytic murein transglycosylase, soluble (Slt)	COG0741	SLT	K08309
3NKHY	NAD(P)H-binding	ACIAD3234		conserved hypothetical protein; putative nucleoside-diphosphate-sugar epimerase		NAD_binding_10
3NIIW	Provides the (R)-glutamate required for cell wall biosynthesis	ACIAD3257	murI	glutamate racemase	COG0796	Asp_Glu_race	K01776
3NK2E	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ACIAD3322	ispH	4-hydroxy-3-methylbut-2-enyl diphosphate reductase (also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with relA to maintain it in an inactive form during normal growth.)	COG0761	LYTB	K03527
3NSQG	Pili and flagellar-assembly chaperone, PapD N-terminal domain	ACIAD3335		putative pili assembly chaperone (PapD-like)	COG3121	PapD_N	K07346
3NIXG	macromolecule glycosylation	ACIAD3337	pglL	oligosaccharyltransferase		PglL_A, Wzy_C, Wzy_C_2
3NJYW	penicillin-binding protein	ACIAD3361	mrcA	penicillin binding protein	COG0744	PCB_OB, Transgly, Transpeptidase	K05366
3NJV1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	ACIAD3363	mraY	phospho-N-acetylmuramoyl-pentapeptide transferase	COG0472	Glycos_transf_4	K01000
3NJ67	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	ACIAD3364	murF	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase) (D-alanyl-D- alanine-adding enzyme)	COG0770	Mur_ligase, Mur_ligase_C, Mur_ligase_M	K01929
3NKQI	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	ACIAD3365	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase	COG0769	Mur_ligase_C, Mur_ligase_M	K01928
3NIFN	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ACIAD3366	ftsI	septum formation, penicillin binding protein 3, peptidoglycan synthetase	COG0768	PBP_dimer, Transpeptidase	K03587
3NK1H	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ACIAD3376	czcB	RND divalent metal cation efflux membrane fusion protein	COG0845	HlyD_D23	K15727
3NJYG	Outer membrane efflux protein	ACIAD3378	czcC	outer membrane protein precursor	COG1538	OEP	K15725
3NJKG	Outer membrane efflux protein	ACIAD3421		putative outer membrane protein precursor		OEP
3NJIY	Barrel-sandwich domain of CusB or HlyD membrane-fusion	ACIAD3424	mdtA	membrane protein inolved in drug resistance	COG0845	HlyD_D23	K07799
3NJ7G	Mycolic acid cyclopropane synthetase	ACIAD3442		putative methyltransferase		Methyltransf_25
3NIKZ	Belongs to the BCCT transporter (TC 2.A.15) family	ACIAD3460		glycine betaine transport protein	COG1292	BCCT	K02168
3NJ9B	Mechanosensitive ion channel	ACIAD3477		conserved hypothetical protein; putative membrane protein		MS_channel
3NJGR	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	ACIAD3479	kdtA	3-deoxy-D-manno-2-octulosonate transferase	COG1519	Glycos_transf_1, Glycos_transf_N	K02527
3NKBI	Peptidase family M23	ACIAD3508		putative peptidase		Peptidase_M23
3NJID	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	ACIAD3510	lpxC	UDP-3-O-acyl-N-acetylglucosamine deacetylase	COG0774	LpxC	K02535
3NK5E	Belongs to the MurCDEF family	ACIAD3516	murC	UDP-N-acetylmuramate--alanine ligase	COG0773	Mur_ligase, Mur_ligase_C, Mur_ligase_M	K01924
3NJ13	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	ACIAD3517	murG	UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	COG0707	Glyco_tran_28_C, Glyco_transf_28	K02563
3NJMX	Nucleoside-specific channel-forming protein, Tsx	ACIAD3539		conserved hypothetical protein		Channel_Tsx
3NJT4	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	ACIAD3575	glmU	bifunctional protein [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]	COG1207	Hexapep, NTP_transf_3	K04042
3NKBM	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	ACIAD3576	glmS	glucosamine--fructose-6-phosphate aminotransferase	COG0449	GATase_6, SIS	K00820
3NJK7	Gram-negative-bacterium-type cell outer membrane assembly	ACIAD3586		putative lipoprotein-34 precursor (NlpB)
3NKAS	Peptidase family M23	ACIAD3607		putative peptidase	COG0739	Peptidase_M23	K21472
3NIFF	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ACIAD3625		putative RND efflux membrane fusion protein precursor	COG0845	HlyD_D23	K18302
3NIZ7	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	ACIAD3643		fragment of conserved hypothetical protein (part 1)
3NIZ7	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	ACIAD3644		fragment of conserved hypothetical protein (part 2)
3NT4R	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ACIAD3647	ppiA	peptidyl-prolyl cis-trans isomerase precursor (PPIase) (Rotamase)	COG0652	Pro_isomerase	K03767
3NIM8	Lytic murein transglycosylase	ACIAD3657		putative membrane-bound lytic murein transglycosylase		PG_binding_1, SLT_2
3NJUJ	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	ACIAD3663	mpl	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase	COG0773	Mur_ligase, Mur_ligase_C, Mur_ligase_M	K02558
3NIES	Outer membrane efflux protein	ACIAD3675		putative outer membrane protein		OEP

3NJUG

This protein specifically catalyzes the removal of signal peptides from prolipoproteins

ACIAD0021

lspA

prolipoprotein signal peptidase (Signal peptidase II.)

COG0597

Peptidase_A8

K03101

3NJ27

peptidyl-prolyl cis-trans isomerase

ACIAD0065

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans isomerase (rotamase)

COG0545

FKBP_C, FKBP_N

K03773

3NJF4

Polysaccharide biosynthesis/export protein

ACIAD0070

wza

polysaccharide export protein

COG1596

Poly_export, SLBB

K01991

3NJSX

Belongs to the UDP-glucose GDP-mannose dehydrogenase family

ACIAD0072

ugd

UDP-glucose 6-dehydrogenase

COG1004

UDPG_MGDP_dh, UDPG_MGDP_dh_C, UDPG_MGDP_dh_N

K00012

1SA3F

glycosyl transferase family 2

ACIAD0074

putative glycosyl transferase family 2

Glycos_transf_2

3NIR1

RmlD substrate binding domain

ACIAD0076

rmlB

dTDP-D-glucose-4,6-dehydratase

COG1088

GDP_Man_Dehyd

K01710

3NM08

Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose

ACIAD0078

rmlD

dTDP-4-dehydrorhamnose reductase (dTDP-4-keto-L- rhamnose reductase) (dTDP-6-deoxy-L-mannose dehydrogenase) (dTDP-L- rhamnose synthetase)

COG1091

RmlD_sub_bind

K00067

3NJY8

Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis

ACIAD0079

rmlA

dTDP-glucose pyrophosphorylase (glucose-1-phosphate thymidylyltransferase)

COG1209

NTP_transferase

K00973

3NJVJ

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose

ACIAD0080

rmlC

dTDP-4-keto-6-deoxy-D-glucose-3,5-epimerase

COG1898

dTDP_sugar_isom

K01790

1STQD

Glycosyl transferases group 1

ACIAD0081

putative glycosyl transferase family 1

Glycos_transf_1

3NQM1

Glycosyltransferase like family 2

ACIAD0082

putative glycosyl transferase family 2 (rhamnosyl transferase)

COG1216

Glycos_transf_2

K07011

3NPSW

Glycosyl transferases group 1

ACIAD0084

putative glycosyl transferase family 1 (mannosyl transferase)

Glyco_transf_4, Glycos_transf_1

3NMRW

Belongs to the mannose-6-phosphate isomerase type 2 family

ACIAD0086

epsM

bifunctional protein [Includes: Mannose-6-phosphate isomerase (Phosphomannose isomerase) (Pmi) (Phosphohexomutase); Mannose-1-phosphate guanylyl transferase (Gdp) (GDP-mannose pyrophosphorylase) (Gmp)]

COG0662, COG0836

MannoseP_isomer, NTP_transferase

K16011

3NIGZ

Belongs to the UDP-glucose GDP-mannose dehydrogenase family

ACIAD0087

putative UDP-glucose/GDP-mannose dehydrogenase

COG0677

UDPG_MGDP_dh, UDPG_MGDP_dh_C, UDPG_MGDP_dh_N

K02474

3NK1T

3-beta hydroxysteroid dehydrogenase/isomerase family

ACIAD0088

putative NAD-dependent epimerase/dehydratase (WbpP)

Epimerase

K02473

3NMJE

Glycosyltransferase Family 4

ACIAD0090

putative glycosyl transferase family 1

Glyco_transf_4, Glycos_transf_1

3NKJC

Glycosyltransferase Family 4

ACIAD0091

putative glycosyl transferase family 1

Glyco_trans_1_4, Glyco_transf_4

3NMAJ

Glycosyl transferases group 1

ACIAD0092

putative glycosyl transferase family 1

Glyco_trans_1_4, Glyco_trans_4_2

3NKCB

Bacterial sugar transferase

ACIAD0093

putative UDP-galactose phosphate transferase (WeeH)

Bac_transf

3NIY7

RmlD substrate binding domain

ACIAD0096

putative dTDP-glucose-4,6-dehydratase/UDP-glucose 4-epimerase (WeeK) (WbpM)

CoA_binding_3, Polysacc_synt_2

3NKCB

Bacterial sugar transferase

ACIAD0098

putative UDP-glucose lipid carrier transferase/glucose-1-phosphate transferase in colanic acid gene cluster (WcaJ)

COG2148

Bac_transf, CoA_binding_3

K03606

3NKR1

UTP-glucose-1-phosphate uridylyltransferase

ACIAD0099

galU

UTP-glucose-1-phosphate uridylyltransferase

COG1210

NTP_transferase

K00963

3NJGE

Belongs to the UDP-glucose GDP-mannose dehydrogenase family

ACIAD0100

putative UDP-glucose 6-dehydrogenase (Ugd) (Udg)

COG1004

UDPG_MGDP_dh, UDPG_MGDP_dh_C

K00012

3NII4

UDP-glucose 4-epimerase

ACIAD0102

galE

UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase)

COG1087

Epimerase

K01784

3NIXG

macromolecule glycosylation

ACIAD0103

pglL

O-oligosaccharyltransferase

PglL_A, Wzy_C, Wzy_C_2

3NNNM

Pili assembly chaperone PapD, C-terminal domain

ACIAD0123

putative pili assembly chaperone

PapD_C, PapD_N

3NIFI

Belongs to the DapA family

ACIAD0130

kdgD

5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy- glucarate dehydratase)

COG0329

DHDPS

K01707

1T2BF

Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane

ACIAD0139

putative outer membrane protein

3NMQ7

Lysin motif

ACIAD0168

LysM domain-containing protein

Hydrolase_2, LysM

3NIWK

TonB dependent receptor

ACIAD0214

putative outer membrane copper receptor (OprC)

COG1629

Plug, TonB_dep_Rec

K02014

3NIEB

Glycosyl hydrolases family 25

putative lysozyme

Glyco_hydro_25

tail specific protease

ACIAD0257

putative periplasmic carboxyl-terminal protease

COG0793

Peptidase_S41

K03797

3NK5B

Belongs to the peptidase S11 family

ACIAD0262

pbpG

D-alanyl-D-alanine endopeptidase, penicillin-binding protein 7 and penicillin-binding protein 8

COG1686

Peptidase_S11

K07262

3NKJJ

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

ACIAD0270

murD

UDP-N-acetylmuramoylalanine-D-glutamate ligase

COG0771

Mur_ligase_C, Mur_ligase_M

K01925

3NJQ1

Outer membrane efflux protein

ACIAD0278

tolC

channel-tunnel spanning the outer membrane and periplasm segregation of daughter chromosomes

OEP

OmpW family

putative outer membrane protein W

COG3047

OmpW

K07275

3NMUN

Asp/Glu/Hydantoin racemase

ACIAD0318

racD

D-aspartate racemase

COG1794

Asp_Glu_race

K01779

3NNFJ

COG3209 Rhs family protein

ACIAD0339

conserved hypothetical protein

3NJE9

Pili assembly chaperone PapD, C-terminal domain

ACIAD0388

acuD

fimbrial chaperone AcuD

COG3121

PapD_C, PapD_N

K07346

3NIIR

Transfers the fatty acyl group on membrane lipoproteins

ACIAD0415

lnt

apolipoprotein N-acyltransferase, copper homeostasis protein

COG0815

CN_hydrolase

K03820

3NJCZ

Glycosyl transferase 4-like domain

ACIAD0482

putative glycosyltransferase

Glyco_transf_4, Glycos_transf_1

3NJM6

Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)

ACIAD0484

lpxP

Lipid A biosynthesis (KDO) 2-(lauroyl)-lipid IVA acyltransferase (Heat shock protein B)

COG1560

Lip_A_acyltrans

K02517

3NIUX

Gamma-glutamyltranspeptidase

ACIAD0485

putative gamma-glutamyltranspeptidase

COG0405

G_glu_transpept

K00681

3NM4S

Gram-negative bacterial TonB protein C-terminal

putative TonB

TonB_C

Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins

ACIAD0518

lgt

prolipoprotein diacylglyceryl transferase

COG0682

LGT

K13292

3NK7I

Belongs to the peptidase S41A family

ACIAD0552

prc

carboxy-terminal protease for penicillin-binding protein

COG0793

DUF3340, PDZ, Peptidase_S41

K03797

3NJVX

Glycosyltransferase Family 4

ACIAD0553

putative glycosyl transferase

Glyco_transf_4, Glycos_transf_1

3NIR2

Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane

ACIAD0564

conserved hypothetical protein; putative PQQ enzyme repeat domain protein

COG1520

PQQ_2, PQQ_3

K17713

3NM7H

Glycosyl transferase family 2

ACIAD0572

putative glycosyl transferase (GT2 family)

Glycos_transf_2

3NIJE

Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

ACIAD0576

conserved hypothetical protein

LolA

3NM2D

Mitochondrial fission ELM1

ACIAD0598

conserved hypothetical protein

COG3660

Mito_fiss_Elm1

K07276

3NK6S

COG0463 Glycosyltransferases involved in cell wall biogenesis

ACIAD0601

putative lipopolysaccharide core biosynthesis glycosyl transferase LpsC

Glycos_transf_2

3NKPC

Glycosyl transferases group 1

ACIAD0602

putative glycosyltransferase

Glyco_transf_4, Glycos_transf_1

3NTK6

Glycosyltransferase family 25 (LPS biosynthesis protein)

ACIAD0604

putative glycosyltransferase involved in LPS biosynthesis

Glyco_transf_25

3NIQJ

Sporulation related domain

ACIAD0645

conserved hypothetical protein

SPOR

3NJ7Z

Belongs to the ompA family

ACIAD0653

putative lipoprotein precursor

OmpA

3NIUB

Belongs to the EPSP synthase family. MurA subfamily

ACIAD0660

murA

UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT)

COG0766

EPSP_synthase

K00790

3NJM8

Belongs to the ompA family

ACIAD0697

putative Outer membrane protein precursor (OmpA-like)

COG2885

OMP_b-brl, OmpA

K03286

3NN59

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell

ACIAD0704

mscL

mechanosensitive channel

MscL

Conserved TM helix

conserved hypothetical protein; putative membrane protein

TM_helix

3NIVF

Nucleoside-specific channel-forming protein, Tsx

ACIAD0769

tsx

nucleoside-specific channel-forming protein

Channel_Tsx

Membrane

conserved hypothetical protein

3NM18

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

ACIAD0784

nolF

nodulation protein

HlyD_3

3NJPV

Involved in formation and maintenance of cell shape

ACIAD0826

mreC

rod shape-determining protein

COG1792

MreC

K03570

3NN3U

rod shape-determining protein MreD

ACIAD0828

mreD

rod shape-determining protein

MreD

NmrA-like family

putative dehydrogenase

Epimerase

3NIW7

Belongs to the ompA family

ACIAD0898

putative outer membrane protein

OmpA

3NT6T

Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane

ACIAD0909

smpA

outer membrane lipoprotein

COG2913

SmpA_OmlA

K06186

3NIUX

Gamma-glutamyltranspeptidase

ACIAD0929

ggt

gamma-glutamyltranspeptidase precursor

COG0405

G_glu_transpept

K00681

1SI2C

COG3209 Rhs family protein

ACIAD0943

conserved hypothetical protein

3NIKZ

Belongs to the BCCT transporter (TC 2.A.15) family

ACIAD1012

betT2

high-affinity choline transporter (BCCT family)

COG1292

BCCT

K02168

3NJ8M

Glycosyl transferase family 21

ACIAD1030

putative transport protein (VGP family) (Haemin storage system) (HmsR)

COG1215

Glyco_tranf_2_3

K11936

3NIFT

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors

ACIAD1061

mtgA

monofunctional biosynthetic peptidoglycan transglycosylase

Transgly

RHS Repeat

putative RHS-related protein

RHS_repeat

3NNDC

NlpE N-terminal domain

ACIAD1085

putative lipoprotein

NlpE

3NJ50

Belongs to the transpeptidase family. MrdA subfamily

ACIAD1101

pbpA

penicillin-binding protein 2

COG0768

PBP_dimer, Transpeptidase

K05515

3NJBH

Dolichyl-phosphate-mannose-protein mannosyltransferase

ACIAD1117

putative membrane glycosyltransferase (GT83 family)

PMT_2

3NJ1D

Glycosyltransferase like family 2

ACIAD1119

putative bactoprenol glycosyl transferase, phage origin

COG0463

Glycos_transf_2

K20534

3NKSP

LppC putative lipoprotein

ACIAD1131

conserved hypothetical protein; putative signal peptide

COG3107

LppC

K07121

3NJAK

COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)

ACIAD1138

bifunctional protein [Includes: lytic murein transglycosylase C, membrane-bound (MtlD); putative cell wall hydrolase]

LysM, SLT

3NJIY

Barrel-sandwich domain of CusB or HlyD membrane-fusion

ACIAD1157

putative RND transporter, membrane fusion protein

COG0845

HlyD_D23

K07799

3NJKG

Outer membrane efflux protein

ACIAD1160

putative membrane channel protein

OEP

3NJE2

Belongs to the UDP-N-acetylglucosamine 2-epimerase family

ACIAD1175

wecB

UDP-N-acetyl glucosamine-2-epimerase

COG0381

Epimerase_2

K01791

3NT04

Glycosyl transferase family 21

ACIAD1178

putative glycosyltransferase

Glyco_tranf_2_3

3NIWC

Belongs to the peptidase S11 family

ACIAD1184

putative D-ala-D-ala-carboxypeptidase, penicillin-binding protein

Peptidase_S11

OmpW family

putative outer membrane W signal peptide protein

COG3047

OmpW

K07275

3NK5A

Belongs to the peptidase S11 family

ACIAD1225

dacC

D-ala-D-ala-carboxypeptidase; penicillin-binding protein 5 (precursor)

COG1686

PBP5_C, Peptidase_S11

K07258

3NK2K

Peptidase family M23

ACIAD1229

nlpD

lipoprotein precursor

LysM, Peptidase_M23

Peptidase family M48

conserved hypothetical protein; putative Zn-dependent protease with chaperone function

Peptidase_M48

3NJDC

Phospholipase

ACIAD1354

putative phospholipase A1 precursor (PldA)

PLA1

zinc metalloprotease

putative membrane-associated Zn-dependent proteases 1

COG0750

PDZ_2, Peptidase_M50

K11749

3NJMK

Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane

ACIAD1378

putative outer membrane protein

COG4775

Bac_surface_Ag, POTRA

K07277

3NJVP

Outer membrane protein (OmpH-like)

ACIAD1379

putative outer membrane protein (OmpH)

COG2825

OmpH

K06142

3NJ49

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

ACIAD1380

lpxD

UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase

COG1044

Hexapep, Hexapep_2, LpxD

K02536

3NJGX

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

ACIAD1382

lpxA

UDP-acetylglucosamine acyltransferase

COG1043

Acetyltransf_11, Hexapep

K00677

3NKKX

Nucleoside-diphosphate-sugar epimerases

ACIAD1390

conserved hypothetical protein

Semialdhyde_dh

3NKGZ

Gram-negative bacterial TonB protein C-terminal

ACIAD1477

conserved hypothetical protein; putative TonB-related protein

TonB_C

3NJ4R

Arabinose 5-phosphate isomerase

ACIAD1482

kdsD

D-arabinose 5-phosphate isomerase

COG0517, COG0794

CBS, SIS

K06041

3NJQY

Outer membrane efflux protein

ACIAD1487

putative outer membrane efflux protein, type I secretion protein

COG1538

OEP

K12543

3NKF2

HlyD membrane-fusion protein of T1SS

ACIAD1489

putative protein secretion efflux system, membrane fusion protein (hemolysin-type secretion transmembrane protein) (superfamily ABC, membrane)

COG0845

Biotin_lipoyl_2, HlyD_3

K12542

3NT4I

Gram-negative bacterial TonB protein C-terminal

ACIAD1528

putative tonB-like protein

COG0810

TonB_C

K03832

3NN7N

Glycosyl transferase family 2

ACIAD1558

putative glycosyl transferase (GT2 family)

Glycos_transf_2

3NT4J

Gram-negative bacterial TonB protein C-terminal

ACIAD1588

putative tonB-like protein

COG0810

TonB_C

K03832

3NSQQ

Lipocalin-like domain

ACIAD1626

putative outer membrane lipoprotein (lipocalin)

COG3040

Lipocalin_2

K03098

3NJM9

Mycolic acid cyclopropane synthetase

ACIAD1630

cfa

cyclopropane-fatty-acyl-phospholipid synthase

COG2230

CMAS

K00574

3NKMF

Mycolic acid cyclopropane synthetase

ACIAD1632

putative cyclopropane-fatty-acyl-phospholipid synthase

COG2230

CMAS

K00574

3NIRJ

Acetyltransferase (GNAT) domain

ACIAD1637

antibiotic resistance protein (acepita)

Acetyltransf_4

SmpA / OmlA family

putative antigen

OmpA, SmpA_OmlA

3NMGF

Transglycosylase SLT domain

ACIAD1663

conserved hypothetical protein

SLT

3NSMF

LrgB-like family

ACIAD1673

conserved hypothetical protein; putative membrane protein

LrgB

3NKF0

Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane

ACIAD1697

dcaP

porin precurseur in catabolism of dicarboxylic acids

Sugarporin_N

3NK6E

Carbohydrate-selective porin, OprB family

ACIAD1715

quiX

porin

COG3659

OprB

K07267

3NJEP

Mechanosensitive ion channel

ACIAD1869

putative transporter with mechanosensitive ion channel.

COG0668

MS_channel

K16053

3NJJM

RmlD substrate binding domain

ACIAD1891

putative UDP-galactose 4-epimerase (GalE-like)

Epimerase

Cell wall formation

murB

UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding

COG0812

FAD_binding_4, MurB_C

K00075

3NIHT

Belongs to the KdsA family

ACIAD2002

kdsA

2-dehydro-3-deoxyphosphooctonate aldolase

COG2877

DAHP_synth_1

K01627

3NJE7

Linear amide C-N hydrolases, choloylglycine hydrolase family

ACIAD2026

putative choloylglycine hydrolase protein

CBAH

NlpC/P60 family

putative cell wall-associated hydrolases (invasion-associated proteins)

NLPC_P60

3NJFY

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

ACIAD2234

mrcB

bifunctional protein [Includes penicillin-insensitive transglycosylase; penicillin-sensitive transpeptidase] (penicillin-binding protein 1B)

COG0744

Transgly, Transpeptidase, UB2H

K05365

1MWUN

Outer membrane protein (Porin)

ACIAD2246

putative outer membrane porin protein precursor

Porin_4

3NJBT

Peptidoglycan polymerase that is essential for cell wall elongation

ACIAD2263

rodA

rod shape-determining protein

COG0772

FTSW_RODA_SPOVE

K05837

3NKMR

Transglycosylase SLT domain

ACIAD2264

mltB

membrane-bound lytic murein transglycosylase B

COG2951

SLT_2

K08305

3NJEK

Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides

ACIAD2265

putative rare lipoprotein A family (RlpA-like)

DPBB_1

OmpW family

conserved hypothetical protein; putative outer membrane protein

OmpW

3NJDS

Gram-negative porin

ACIAD2319

putative porin precursor

Porin_4

3NKDW

Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

ACIAD2324

lpxB

lipid A-disaccharide synthase

COG0763

LpxB

K00748

3NK83

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

ACIAD2362

kdsB

3-deoxy-manno-octulosonate cytidylyltransferase

COG1212

CTP_transf_3

K00979

3NJHV

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

ACIAD2363

lpxK

tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase)

COG1663

LpxK

K00912

3NJ0U

COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)

ACIAD2369

putative nucleotidyl transferase

COG1208

NTP_transferase

K00992

3NJSZ

Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane

ACIAD2371

ostA

organic solvent tolerance protein precursor or increased membrane permeability protein

COG1452

OstA, OstA_C

K04744

3NIEI

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation

ACIAD2372

surA

peptidyl-prolyl cis-trans isomerase

COG0760

Rotamase, Rotamase_3, SurA_N

K03771

3NII7

TamB, inner membrane protein subunit of TAM complex

ACIAD2402

conserved hypothetical protein

TamB

Surface antigen

conserved hypothetical protein; putative outer membrane protein

COG0729

Bac_surface_Ag, POTRA_TamA_1

K07278

3NJY7

ErfK YbiS YcfS YnhG family protein

ACIAD2475

conserved hypothetical protein; putative signal peptide

PG_binding_1, YkuD

3NM4V

Lipocalin-like domain

ACIAD2568

putative outer membrane lipoprotein

COG3040

Lipocalin_2

K03098

3NK8H

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner

ACIAD2584

lepA

GTP-binding protein

COG0481

EFG_C, GTP_EFTU, GTP_EFTU_D2, LepA_C

K03596

3NKQS

TonB C terminal

ACIAD2621

tolA

tolerance to group A colicins, single-stranded filamentous DNA phage, required for OM integrity

COG3064

Fibrinogen_BP, TonB_2

K03646

3NKBN

Belongs to the ompA family

ACIAD2623

pal

peptidoglycan-associated lipoprotein precursor

COG2885

OmpA

K03640

3NIFD

Bacterial lipid A biosynthesis acyltransferase

ACIAD2638

putative lipid A biosynthesis lauroyl acyltransferase

COG1560

Lip_A_acyltrans

K02517

3NIGK

MacB-like periplasmic core domain

ACIAD2641

lolC

transport protein of outer membrane lipoproteins (ABC superfamily, membrane)

COG4591

FtsX, MacB_PCD

K09808

3NIK7

Outer membrane efflux protein

ACIAD2648

conserved hypothetical protein; putative outer membrane efflux protein

OEP

3NK8Q

OmpA family

ACIAD2682

putative outer membrane lipoprotein

COG2885

OmpA

K03286

3NIZ9

D-alanyl-D-alanine carboxypeptidase

ACIAD2699

conserved hypothetical protein; putative membrane protein

Peptidase_M15_4

self proteolysis

conserved hypothetical protein

COG3209

self proteolysis

ACIAD2704

conserved hypothetical protein

3NT02

RHS Repeat

ACIAD2709

hypothetical protein

RHS_repeat

3NJV2

COG3209 Rhs family protein

ACIAD2710

hypothetical protein

3NK4E

Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane

ACIAD2824

conserved hypothetical protein; putative protein (DcaP-like)

3NISE

Transglycosylase SLT domain

ACIAD2827

putative periplasmic binding protein of transport/transglycosylase

SLT

3NJTE

Transglycosylase SLT domain

ACIAD2832

putative transglycosylase

SLT

3NNIC

Recycling of diacylglycerol produced during the turnover of membrane phospholipid

ACIAD2837

dgkA

diacylglycerol kinase

COG0818

DAGK_prokar

K00901

3NJGY

Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane

ACIAD2898

putative competence protein (ComL)

COG4105

TPR_18

K05807

3NJDU

Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein

ACIAD2902

lolB

outer-membrane lipoprotein precursor

COG3017

LolB

K02494

3NNP5

Acetyltransferase (GNAT) family

ACIAD2918

putative acyltransferase

Acetyltransf_1

3NKC7

Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

ACIAD2937

lolA

outer-membrane lipoproteins carrier protein

COG2834

LolA

K03634

3NJZ0

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

ACIAD2943

putative RND multidrug efflux membrane fusion protein MexA precursor

COG0845

HlyD_D23

K03585

3NJR2

Outer membrane efflux protein

ACIAD2945

putative outer membrane protein oprM precursor

COG1538

OEP

K18139

3NJ0T

Carbohydrate-selective porin, OprB family

ACIAD2984

putative glucose-sensitive porin (OprB-like )

OprB

LrgB-like family

conserved hypothetical protein; putative membrane protein

LrgB

3NK9B

MlaA lipoprotein

ACIAD3018

putative lipoprotein precursor (VacJ) transmembrane

COG2853

MlaA

K04754

3NIPP

Mechanosensitive ion channel

ACIAD3026

putative small conductance mechanosensitive ion channel

MS_channel

3NMVT

Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins

ACIAD3049

putative TonB_C domain-containing protein

TonB_2

3NMK0

COG3209 Rhs family protein

ACIAD3087

conserved hypothetical protein

3NKK6

Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane

ACIAD3107

putative minor lipoprotein

COG2980

K03643

3NJBY

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

ACIAD3109

putative secretion protein (HlyD family)

COG0845

HlyD_D23

K13888

3NIGG

Outer membrane efflux protein

ACIAD3111

putative outer membrane protein precursor

OEP

3NMTU

chlorophyll binding

ACIAD3114

conserved hypothetical protein

3NJXX

COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)

ACIAD3157

putative lytic murein transglycosylase, soluble (Slt)

SLT

NAD(P)H-binding

conserved hypothetical protein; putative nucleoside-diphosphate-sugar epimerase

NAD_binding_10

3NIIW

Provides the (R)-glutamate required for cell wall biosynthesis

ACIAD3257

murI

glutamate racemase

COG0796

Asp_Glu_race

K01776

3NK2E

Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis

ACIAD3322

ispH

4-hydroxy-3-methylbut-2-enyl diphosphate reductase (also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with relA to maintain it in an inactive form during normal growth.)

COG0761

LYTB

K03527

3NSQG

Pili and flagellar-assembly chaperone, PapD N-terminal domain

ACIAD3335

putative pili assembly chaperone (PapD-like)

COG3121

PapD_N

K07346

3NIXG

macromolecule glycosylation

ACIAD3337

pglL

oligosaccharyltransferase

PglL_A, Wzy_C, Wzy_C_2

3NJYW

penicillin-binding protein

ACIAD3361

mrcA

penicillin binding protein

COG0744

PCB_OB, Transgly, Transpeptidase

K05366

3NJV1

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

ACIAD3363

mraY

phospho-N-acetylmuramoyl-pentapeptide transferase

COG0472

Glycos_transf_4

K01000

3NJ67

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

ACIAD3364

murF

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase) (D-alanyl-D- alanine-adding enzyme)

COG0770

Mur_ligase, Mur_ligase_C, Mur_ligase_M

K01929

3NKQI

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan

ACIAD3365

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase

COG0769

Mur_ligase_C, Mur_ligase_M

K01928

3NIFN

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum

ACIAD3366

ftsI

septum formation, penicillin binding protein 3, peptidoglycan synthetase

COG0768

PBP_dimer, Transpeptidase

K03587

3NK1H

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

ACIAD3376

czcB

RND divalent metal cation efflux membrane fusion protein

COG0845

HlyD_D23

K15727

3NJYG

Outer membrane efflux protein

ACIAD3378

czcC

outer membrane protein precursor

COG1538

OEP

K15725

3NJKG

Outer membrane efflux protein

ACIAD3421

putative outer membrane protein precursor

OEP

3NJIY

Barrel-sandwich domain of CusB or HlyD membrane-fusion

ACIAD3424

mdtA

membrane protein inolved in drug resistance

COG0845

HlyD_D23

K07799

3NJ7G

Mycolic acid cyclopropane synthetase

ACIAD3442

putative methyltransferase

Methyltransf_25

3NIKZ

Belongs to the BCCT transporter (TC 2.A.15) family

ACIAD3460

glycine betaine transport protein

COG1292

BCCT

K02168

3NJ9B

Mechanosensitive ion channel

ACIAD3477

conserved hypothetical protein; putative membrane protein

MS_channel

3NJGR

3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)

ACIAD3479

kdtA

3-deoxy-D-manno-2-octulosonate transferase

COG1519

Glycos_transf_1, Glycos_transf_N

K02527

3NKBI

Peptidase family M23

ACIAD3508

putative peptidase

Peptidase_M23

3NJID

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

ACIAD3510

lpxC

UDP-3-O-acyl-N-acetylglucosamine deacetylase

COG0774

LpxC

K02535

3NK5E

Belongs to the MurCDEF family

ACIAD3516

murC

UDP-N-acetylmuramate--alanine ligase

COG0773

Mur_ligase, Mur_ligase_C, Mur_ligase_M

K01924

3NJ13

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)

ACIAD3517

murG

UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

COG0707

Glyco_tran_28_C, Glyco_transf_28

K02563

3NJMX

Nucleoside-specific channel-forming protein, Tsx

ACIAD3539

conserved hypothetical protein

Channel_Tsx

3NJT4

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain

ACIAD3575

glmU

bifunctional protein [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]

COG1207

Hexapep, NTP_transf_3

K04042

3NKBM

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

ACIAD3576

glmS

glucosamine--fructose-6-phosphate aminotransferase

COG0449

GATase_6, SIS

K00820

3NJK7

Gram-negative-bacterium-type cell outer membrane assembly

ACIAD3586

putative lipoprotein-34 precursor (NlpB)

Peptidase family M23

putative peptidase

Peptidase_M23

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

ACIAD3625

putative RND efflux membrane fusion protein precursor

COG0845

HlyD_D23

K18302

3NIZ7

Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety

ACIAD3643

fragment of conserved hypothetical protein (part 1)

3NIZ7

Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety

ACIAD3644

fragment of conserved hypothetical protein (part 2)

3NT4R

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

ACIAD3647

ppiA

peptidyl-prolyl cis-trans isomerase precursor (PPIase) (Rotamase)

COG0652

Pro_isomerase

K03767

3NIM8

Lytic murein transglycosylase