Genomic Tools

OG ID	OG function	Label	Gene	Product	COG	PFAM short name	KO
3NJWF	Belongs to the ribF family	ACIAD0023	ribF	bifunctional protein [Includes: riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)]	COG0196	FAD_syn, Flavokinase	K11753
3NKGB	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ACIAD0044	ubiG	3-demethylubiquinone-9 3-methyltransferase and 2-octaprenyl-6-hydroxy phenol methylase	COG2227	Methyltransf_23	K00568
3NJD6	Belongs to the NadC ModD family	ACIAD0062	nadC	nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)	COG0157	QRPTase_C, QRPTase_N	K00767
3NJYV	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	ACIAD0128	gudD	D-glucarate dehydratase	COG4948	MR_MLE_C	K01706
3NJDK	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ACIAD0247	ribD	bifunctional protein [Includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase); 5-amino-6-(5- phosphoribosylamino)uracil reductase (HTP reductase) ]	COG1985, COG0117	RibD_C, dCMP_cyt_deam_1	K11752
3NJ7N	Lumazine binding domain	ACIAD0249	ribC	riboflavin synthase alpha chain	COG0307	Lum_binding	K00793
3NKAR	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	ACIAD0276	thiC	hydroxymethylpyrimidine moiety synthesis in thiamin biosynthesis	COG0422	ThiC-associated, ThiC_Rad_SAM	K03147
3NIRA	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	ACIAD0286	hemC	porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)	COG0181	Porphobil_deam, Porphobil_deamC	K01749
3NJF7	Uroporphyrinogen-III synthase	ACIAD0287	hemD	uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen- III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing])	COG1587	HEM4	K01719
3NIFP	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	ACIAD0359	coaE	dephosphocoenzyme A kinase	COG0237	CoaE	K00859
3NIMA	FAD binding domain	ACIAD0381		putative oxidoreductase; putative flavoprotein monooxygenase		FAD_binding_3
3NJ9G	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ACIAD0384	ubiE	S-adenosylmethionine : 2-DMK methyltransferase and 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase	COG2226	Ubie_methyltran	K03183
3NJ05	Putative methyltransferase	ACIAD0420		putative methyltransferase		Methyltransf_4
3NIS7	Involved in the biosynthesis of porphyrin-containing compound	ACIAD0432		putative heme chaperone HemW like		HemN_C, Radical_SAM
3NJ26	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	ACIAD0514	folA	dihydrofolate reductase	COG0262	DHFR_1	K00287
3NJ9F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ACIAD0541	ack	acetate kinase (propionate kinase)	COG0282	Acetate_kinase	K00925
3NJX1	Belongs to the P-Pant transferase superfamily	ACIAD0585		putative holo-(acyl carrier protein) synthase 2 (AcpT) (phophopantetheinyltransferase)	COG2091	ACPS	K06133
3NJBF	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	ACIAD0596	glnE	glutamine synthetase adenylyltransferase	COG1391	GlnD_UR_UTase, GlnE	K00982
3NIXN	Belongs to the folylpolyglutamate synthase family	ACIAD0644	folC	bifunctional protein [Includes: folylpolyglutamate synthase (FPGS); dihydrofolate synthase ].	COG0285	Mur_ligase_M	K11754
3NIF2	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	ACIAD0651	nadA	quinolinate synthetase A	COG0379	NadA	K03517
3NIKM	chorismate binding enzyme	ACIAD0665	pabB	p-aminobenzoate synthetase	COG0147	Chorismate_bind	K01665
3NNKS	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	ACIAD0824	gatC	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	COG0721	Glu-tRNAGln	K02435
3NII6	Reduction of activated sulfate into sulfite	ACIAD0833		putative 5'-adenylylsulfate reductase (APS reductase) (cysH-like)	COG0175	PAPS_reduct	K00390
3NJ23	Biotin/lipoate A/B protein ligase family	ACIAD0841		putative biotin--[acetyl-CoA-carboxylase] synthetase	COG1654, COG0340	BPL_LplA_LipB	K03524
3NJY2	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	ACIAD0856	bioA	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	COG0161	Aminotran_3	K00833
3NJ8J	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	ACIAD0858		putative biotin biosynthesis protein (BioC)	COG0500	Methyltransf_23	K02169
3NK0H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	ACIAD0859	bioD	dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)	COG0132	AAA_26	K01935
3NJ39	Phosphomethylpyrimidine kinase	ACIAD0875	thiD	bifunctional protein [Includes: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)]	COG0351	Phos_pyr_kin	K00941
3NIKS	Belongs to the ALAD family	ACIAD0923	hemB	delta-aminolevulinic acid dehydratase (Porphobilinogen synthase)	COG0113	ALAD	K01698
3NJ7S	Nicotinate phosphoribosyltransferase (NAPRTase) family	ACIAD0963	nadV	nicotinamide phosphoribosyl transferase		NAPRTase	K03462
3NNDK	FAD binding domain	ACIAD0984		putative hydroxylase involved in salicylate metabolism (SalA-like)	COG0654	FAD_binding_3, NAD_binding_8	K00480
3NJIB	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	ACIAD0997		L-aspartate dehydrogenase (NadX)	COG1712	DUF108, NAD_binding_3	K06989
3NIP9	Thiamine pyrophosphate enzyme, central domain	ACIAD0999		putative acetolactate synthase (IlvB-like)	COG0028	TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N	K01652
3NKU5	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	ACIAD1015	lipA	lipoate synthase	COG0320	LIAS_N, Radical_SAM	K03644
3NM04	Nicotinamide mononucleotide transporter	ACIAD1033		putative nucleoside/purine/pyrimidine transport protein (NMN family) (PnuC)	COG3201	NMN_transporter	K03811
3NJXP	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ACIAD1062	ppk	polyphosphate kinase	COG0855	PP_kinase, PP_kinase_C, PP_kinase_N	K00937
3NQZY	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	ACIAD1071	cobQ	cobyric acid synthase	COG1492	CbiA, GATase_3	K02232
3NJJG	Sulfate adenylyltransferase subunit 2	ACIAD1072	cysD	sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit)	COG0175	PAPS_reduct	K00957
3NJ0B	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	ACIAD1073	cysN	ATP-sulfurylase, subunit 1	COG2895	GTP_EFTU	K00956
3NINP	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ACIAD1116	folN	5-formyltetrahydrofolate cyclo-ligase	COG0212	5-FTHF_cyc-lig	K01934
3NK3B	FAD binding domain	ACIAD1127	ubiH	ubiH protein, 2-octaprenyl-6-methoxyphynol hydroxylase, FAD/NAD(P)-binding	COG0654	FAD_binding_3	K03185
3NIR6	Squalene epoxidase	ACIAD1128	ubiF	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase		FAD_binding_3
3NJVG	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	ACIAD1130		putative methyltransferase	COG0313	TP_methylase	K07056
3NIUK	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	ACIAD1200		putative thiamin-phosphate pyrophosphorylase (ThiE)	COG0352	TMP-TENI	K00788
3NJSW	Glutamate-1-semialdehyde aminotransferase	ACIAD1201	hemL	glutamate-1-semialdehyde aminotransferase	COG0001	Aminotran_3	K01845
1RS1C	GNAT family acetyltransferase	ACIAD1279	cphA	Cyanophycin synthetase	COG1181	Mur_ligase_C, Mur_ligase_M, RimK	K03802
3NIEW	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	ACIAD1308	thiG	thiamine biosynthesis protein, thiazole moiety	COG2022	ThiG	K03149
3NPTY	ThiS family	ACIAD1309	thiS	C-terminally thiocarboxylated form is intermediate sulfur donor in thiazole formation; part of ThiF/ThiS complex; complexes with ThiG also	COG2104	ThiS	K03154
3NJWE	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ACIAD1327	tkrA	Glyoxylate reductase / Glyoxylatereductase / Hydroxypyruvate reductase , 2-ketoaldonate reductase, broad specificity	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00090
3NIW6	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	ACIAD1374	ispU	undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)	COG0020	Prenyltransf	K00806
3NJ8F	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	ACIAD1391	rraA	Regulator of ribonuclease activity	COG0684	RraA-like	K02553
3NKZM	Homocysteine S-methyltransferase	ACIAD1418		putative homocysteine S-methyltransferase family protein		S-methyl_trans
3NJZH	FAD binding domain	ACIAD1719	pobA	p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3- monooxygenase)	COG0654	FAD_binding_3	K00481
3NT9V	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	ACIAD1734		putative methyltransferase (EC 2.1.1.-)		LCM
3NKIE	Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase	ACIAD1754	mdcB	2'-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase	COG1767	CitG	K13930
3NN4M	Phosphoribosyl-dephospho-CoA transferase MdcG	ACIAD1758	mdcG	phosphoribosyl-dephospho-CoA transferase (Holo-ACP synthase)		MdcG	K13934
3NKPA	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ACIAD1782	ppk	polyphosphate kinase (Polyphosphoric acid kinase) (ATP- polyphosphate phosphotransferase)	COG0855	PP_kinase, PP_kinase_C, PP_kinase_N	K00937
3NK2I	FAD binding domain	ACIAD1808		putative monooxygenase		FAD_binding_3
3NJX7	Probable molybdopterin binding domain	ACIAD1902	moeA	molybdopterin biosynthesis protein	COG0303	MoCF_biosynth, MoeA_C, MoeA_N	K03750
3NKK0	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	ACIAD1903	moaCB	bifunctional protein [Includes: molybdenum cofactor biosynthesis protein C; molybdenum cofactor biosynthesis protein B]		MoCF_biosynth, MoaC
3NK9M	Molybdopterin converting factor, large subunit	ACIAD1904	moaE	molybdopterin converting factor, large subunit	COG0314	MoaE	K03635
3NPTK	ThiS family	ACIAD1905		conserved hypothetical protein		ThiS
3NKDX	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	ACIAD1906	moaA	molybdopterin biosynthesis, protein A	COG2896	Fer4_12, Mob_synth_C, Radical_SAM	K03639
3NKRG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	ACIAD1907	mobA	molybdopterin-guanine dinucleotide synthase	COG0746	NTP_transf_3	K03752
3NMYH	ATP-grasp in the biosynthetic pathway with Ter operon	ACIAD1963		conserved hypothetical protein		ATPgrasp_Ter
3NJIZ	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	ACIAD1970	dnaX	DNA polymerase III, tau and gamma subunits (DNA elongation factor III)	COG2812	DNA_pol3_delta2, DNA_pol3_gamma3	K02343
3NJ4Q	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	ACIAD1980	tal	transaldolase	COG0176	TAL_FSA	K00616
3NK3F	Belongs to the carbohydrate kinase PfkB family	ACIAD1992	fruK	1-phosphofructokinase	COG1105	PfkB	K00882
3NJ79	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	ACIAD2011	thiM	hydoxyethylthiazole kinase	COG2145	HK	K00878
3NJFZ	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	ACIAD2037	metK	methionine adenosyltransferase	COG1812, COG0192	S-AdoMet_synt_C, S-AdoMet_synt_M, S-AdoMet_synt_N	K00789
3NJJH	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	ACIAD2045	bioB	biotin synthetase	COG0502	BATS, Radical_SAM	K01012
3NKIK	Iron-containing redox enzyme	ACIAD2095		conserved hypothetical protein		Haem_oxygenas_2
3NKW9	Aldolase/RraA	ACIAD2118		putative demethylmenaquinone methyltransferase (bfnG)		RraA-like
3NIJZ	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ACIAD2231		putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)(PpnK)	COG0061	NAD_kinase	K00858
3NNJP	COG0457 FOG TPR repeat	ACIAD2235		conserved hypothetical protein
3NKK2	Belongs to the Nudix hydrolase family	ACIAD2236		putative bifunctional protein [Includes: dGTP-pyrophosphohydrolase; thiamine phosphate synthase]	COG0494, COG1051	NUDIX, TMP-TENI	K03574
3NKA8	Permease for cytosine/purines, uracil, thiamine, allantoin	ACIAD2247		putative permease	COG1953, COG1457	Transp_cyt_pur	K03457
3NJZS	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	ACIAD2275	lipA	lipoate synthase	COG0320	LIAS_N, Radical_SAM	K03644
3NIJA	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ACIAD2282	sahH	S-adenosyl-L-homocysteine hydrolase	COG0499	AdoHcyase, AdoHcyase_NAD	K01251
3NIPN	6-pyruvoyl tetrahydropterin synthase	ACIAD2353		putative 6-pyruvoyl-tetrahydropterin synthase	COG0720	PTPS	K01737
3NJ95	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	ACIAD2392	rbsK	ribokinase	COG0524	PfkB	K00852
3NK47	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	ACIAD2405		putative ubiquinone biosynthesis protein	COG2941	COQ7	K06134
3NNNF	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	ACIAD2407		putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	COG0801	HPPK	K00950
3NNI7	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	ACIAD2408	folB	dihydroneopterin aldolase	COG1539	FolB	K01633
3NIJ0	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	ACIAD2411		molybdopterin biosynthesis protein (moeB) OR thiamin-thiazole moiety synthesis (thiF)	COG0476	ThiF	K21029
3NIIN	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	ACIAD2422		conserved hypothetical protein	COG1806	Kinase-PPPase	K09773
3NIYC	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ACIAD2455	ubiA	4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase)	COG0382	UbiA	K03179
3NKMX	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ACIAD2456	ubiC	chorismate pyruvate lyase	COG3161	Chor_lyase	K03181
3NIZ1	component II	ACIAD2461	trpG	bifunctional protein:[Includes: para-aminobenzoate synthase glutamine amidotransferase component II (ADC synthase); anthranilate synthase component II]	COG0512	GATase	K01658
3NKQ6	GTP cyclohydrolase	ACIAD2470	folE	GTP cyclohydrolase I	COG0302	GTP_cyclohydroI	K01495
3NIKI	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	ACIAD2474	hemE	uroporphyrinogen decarboxylase	COG0407	URO-D	K01599
3NMAD	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	ACIAD2505	pqqC	coenzyme PQQ synthesis protein C (Coenzyme PQQ synthesis protein I)	COG5424	TENA_THI-4	K06137
3NSYT	Iron-sulfur cluster-binding domain	ACIAD2507	pqqE	coenzyme PQQ synthesis protein E (Coenzyme PQQ synthesis protein III)	COG0535	Fer4_12, Radical_SAM, SPASM	K06139
3NIUI	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	ACIAD2577	pdxJ	Pyridoxine 5'-phosphate synthase	COG0854	PdxJ	K03474
3NJQX	Catalyzes the oxidation of L-aspartate to iminoaspartate	ACIAD2587	nadB	L-aspartate oxidase (quinolinate synthetase B)	COG0029	FAD_binding_2, Succ_DH_flav_C	K00278
3NIK0	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	ACIAD2590	pabC	4-amino-4-deoxychorismate lyase	COG0115	Aminotran_4	K02619
3NIYT	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	ACIAD2600		putative radical activating enzyme	COG0602	Fer4_14, Radical_SAM	K10026
3NITZ	Cytidylyltransferase-like	ACIAD2606	nadM	nicotinamide/nicotinate-nucleotide adenylyltransferase		CTP_transf_like
3NKB6	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	ACIAD2667	pdxB	erythronate-4-phosphate dehydrogenase	COG0111	2-Hacid_dh, 2-Hacid_dh_C, DUF3410	K03473
3NMCH	chorismate binding enzyme	ACIAD2776	fbsB	isochorismate synthetase	COG1169	Chorismate_bind	K02361
3NK9R	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	ACIAD2842	pckG	phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK)	COG1274	PEPCK_C, PEPCK_N	K01596
3NJMW	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	ACIAD2852	folP	7,8-dihydropteroate synthase	COG0294	Pterin_bind	K00796
3NIYF	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	ACIAD2888	nadE	NAD synthetase, NH3/glutamine-dependent	COG0388, COG0171	CN_hydrolase, NAD_synthase	K01950
3NJTZ	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	ACIAD2893	coaD	phosphopantetheine adenylyltransferase	COG0669	CTP_transf_like	K00954
3NJ4K	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	ACIAD2900	hemA	glutamyl tRNA reductase	COG0373	GlutR_N, GlutR_dimer, Shikimate_DH	K02492
3NN4I	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	ACIAD2911	panD	aspartate 1-decarboxylase precursor	COG0853	Asp_decarbox	K01579
3NIMM	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ACIAD2913	ribB	3,4 dihydroxy-2-butanone-4-phosphate synthase	COG0108	DHBP_synthase	K02858
3NIWJ	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	ACIAD2927	lipB	lipoate-protein ligase B (Lipoate biosynthesis protein B)	COG0321	BPL_LplA_LipB	K03801
3NISX	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	ACIAD2934	cysG	multifunctional protein [Includes: Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2 oxidase ; Ferrochelatase ] (Siroheme synthase)	COG0007, COG1648	CysG_dimeriser, NAD_binding_7, TP_methylase	K02302
3NK0C	Belongs to the FPP GGPP synthase family	ACIAD2940	ispB	octaprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase) (OPP synthetase)	COG0142	polyprenyl_synt	K02523
3NK6Z	Belongs to the FPP GGPP synthase family	ACIAD2968	ispA	geranyltranstransferase (farnesyldiphosphate synthase) (FPP synthase)	COG0142	polyprenyl_synt	K00795
3NIRN	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	ACIAD3010	pdxA	4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)	COG1995	PdxA	K00097
3NJJJ	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	ACIAD3060	panC	pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)	COG0414	Pantoate_ligase	K01918
3NIP8	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	ACIAD3061	panB	3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase)	COG0413	Pantoate_transf	K00606
3NNAE	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	ACIAD3062	folK	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK)	COG0801	HPPK	K00950
3NIH2	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1	ACIAD3088		putative tRNA threonylcarbamoyladenosine dehydratase (tcdA)	COG1179	ThiF	K22132
3NIUP	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ACIAD3102	ilvC	acetohydroxy acid isomeroreductase and 2-dehydropantoate 2-reductase	COG0059	IlvC, IlvN	K00053
3NJ1B	acetolactate synthase	ACIAD3104	ilvI	acetolactate synthase III, large subunit	COG0028	TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N	K01652
3NJ8G	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	ACIAD3125	dfp	bifunctional protein [Includes: 4'-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding]	COG0452	DFP, Flavoprotein	K13038
3NJ9J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	ACIAD3135		putative tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC	COG4121, COG0665	DAO, Methyltransf_30	K15461
3NIWY	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	ACIAD3247	dxs	1-deoxyxylulose-5-phosphate synthase	COG1154	DXP_synthase_N, Transket_pyr, Transketolase_C	K01662
3NJJB	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ACIAD3249	ribA	GTP cyclohydrolase II	COG0807	GTP_cyclohydro2	K01497
3NJJ9	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	ACIAD3250	hemF	coproporphyrinogen III oxidase	COG0408	Coprogen_oxidas	K00228
3NJ4U	Catalyzes the ferrous insertion into protoporphyrin IX	ACIAD3255	hemH	ferrochelatase	COG0276	Ferrochelatase	K01772
3NJ61	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ACIAD3278	hprA	glycerate dehydrogenase	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00018
3NINV	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ACIAD3302	serA	D-3-phosphoglycerate dehydrogenase	COG0111	2-Hacid_dh, 2-Hacid_dh_C	K00058
3NJ7P	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	ACIAD3501	pdxH	pyridoxamine 5'-phosphate oxidase (acts also on pyridoxine phosphate and pyridoxine)	COG0259	PNP_phzG_C, Putative_PNPOx	K00275
3NIX2	Belongs to the prokaryotic GSH synthase family	ACIAD3518	gshB	glutathione synthetase	COG0189	GSH-S_ATP, GSH-S_N	K01920
3NK2I	FAD binding domain	ACIAD3540	hpxO	FAD-dependent urate oxidase		FAD_binding_3	K16839
3NK8B	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	ACIAD3549	gshA	gamma-glutamate-cysteine ligase	COG2918	Glu_cys_ligase	K01919
3NJ8E	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ACIAD3570	ribB/A	bifunctional protein [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II]	COG0108, COG0807	DHBP_synthase, GTP_cyclohydro2	K14652
3NIEQ	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ACIAD3571	ribH	6,7-dimethyl-8-ribityllumazine synthase (Lumazine synthase)(riboflavin synthase beta chain)	COG0054	DMRL_synthase	K00794
3NKDN	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	ACIAD3573	thiL	thiamin-monophosphate kinase	COG0611	AIRS, AIRS_C	K00946
3NJ42	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ACIAD3627	ppc	phosphoenolpyruvate carboxylase	COG1892, COG2352	PEPcase	K01595

Belongs to the ribF family

ribF

bifunctional protein [Includes: riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)]

COG0196

FAD_syn, Flavokinase

K11753

3NKGB

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway

ACIAD0044

ubiG

3-demethylubiquinone-9 3-methyltransferase and 2-octaprenyl-6-hydroxy phenol methylase

COG2227

Methyltransf_23

K00568

3NJD6

Belongs to the NadC ModD family

ACIAD0062

nadC

nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

COG0157

QRPTase_C, QRPTase_N

K00767

3NJYV

Mandelate racemase / muconate lactonizing enzyme, C-terminal domain

ACIAD0128

gudD

D-glucarate dehydratase

COG4948

MR_MLE_C

K01706

3NJDK

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

ACIAD0247

ribD

bifunctional protein [Includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase); 5-amino-6-(5- phosphoribosylamino)uracil reductase (HTP reductase) ]

COG1985, COG0117

RibD_C, dCMP_cyt_deam_1

K11752

3NJ7N

Lumazine binding domain

ACIAD0249

ribC

riboflavin synthase alpha chain

COG0307

Lum_binding

K00793

3NKAR

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

ACIAD0276

thiC

hydroxymethylpyrimidine moiety synthesis in thiamin biosynthesis

COG0422

ThiC-associated, ThiC_Rad_SAM

K03147

3NIRA

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

ACIAD0286

hemC

porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)

COG0181

Porphobil_deam, Porphobil_deamC

K01749

3NJF7

Uroporphyrinogen-III synthase

ACIAD0287

hemD

uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen- III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing])

COG1587

HEM4

K01719

3NIFP

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

ACIAD0359

coaE

dephosphocoenzyme A kinase

CoaE

FAD binding domain

putative oxidoreductase; putative flavoprotein monooxygenase

FAD_binding_3

3NJ9G

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

ACIAD0384

ubiE

S-adenosylmethionine : 2-DMK methyltransferase and 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase

COG2226

Ubie_methyltran

K03183

3NJ05

Putative methyltransferase

ACIAD0420

putative methyltransferase

Methyltransf_4

3NIS7

Involved in the biosynthesis of porphyrin-containing compound

ACIAD0432

putative heme chaperone HemW like

HemN_C, Radical_SAM

3NJ26

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis

ACIAD0514

folA

dihydrofolate reductase

COG0262

DHFR_1

K00287

3NJ9F

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction

ACIAD0541

ack

acetate kinase (propionate kinase)

COG0282

Acetate_kinase

K00925

3NJX1

Belongs to the P-Pant transferase superfamily

ACIAD0585

putative holo-(acyl carrier protein) synthase 2 (AcpT) (phophopantetheinyltransferase)

COG2091

ACPS

K06133

3NJBF

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell

ACIAD0596

glnE

glutamine synthetase adenylyltransferase

COG1391

GlnD_UR_UTase, GlnE

K00982

3NIXN

Belongs to the folylpolyglutamate synthase family

ACIAD0644

folC

bifunctional protein [Includes: folylpolyglutamate synthase (FPGS); dihydrofolate synthase ].

COG0285

Mur_ligase_M

K11754

3NIF2

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

ACIAD0651

nadA

quinolinate synthetase A

COG0379

NadA

K03517

3NIKM

chorismate binding enzyme

ACIAD0665

pabB

p-aminobenzoate synthetase

COG0147

Chorismate_bind

K01665

3NNKS

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)

ACIAD0824

gatC

aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C

COG0721

Glu-tRNAGln

K02435

3NII6

Reduction of activated sulfate into sulfite

ACIAD0833

putative 5'-adenylylsulfate reductase (APS reductase) (cysH-like)

COG0175

PAPS_reduct

K00390

3NJ23

Biotin/lipoate A/B protein ligase family

ACIAD0841

putative biotin--[acetyl-CoA-carboxylase] synthetase

COG1654, COG0340

BPL_LplA_LipB

K03524

3NJY2

Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

ACIAD0856

bioA

adenosylmethionine-8-amino-7-oxononanoate aminotransferase

COG0161

Aminotran_3

K00833

3NJ8J

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway

ACIAD0858

putative biotin biosynthesis protein (BioC)

COG0500

Methyltransf_23

K02169

3NK0H

Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring

ACIAD0859

bioD

dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)

COG0132

AAA_26

K01935

3NJ39

Phosphomethylpyrimidine kinase

ACIAD0875

thiD

bifunctional protein [Includes: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)]

COG0351

Phos_pyr_kin

K00941

3NIKS

Belongs to the ALAD family

ACIAD0923

hemB

delta-aminolevulinic acid dehydratase (Porphobilinogen synthase)

COG0113

ALAD

K01698

3NJ7S

Nicotinate phosphoribosyltransferase (NAPRTase) family

ACIAD0963

nadV

nicotinamide phosphoribosyl transferase

NAPRTase

K03462

3NNDK

FAD binding domain

ACIAD0984

putative hydroxylase involved in salicylate metabolism (SalA-like)

COG0654

FAD_binding_3, NAD_binding_8

K00480

3NJIB

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate

ACIAD0997

L-aspartate dehydrogenase (NadX)

COG1712

DUF108, NAD_binding_3

K06989

3NIP9

Thiamine pyrophosphate enzyme, central domain

ACIAD0999

putative acetolactate synthase (IlvB-like)

COG0028

TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N

K01652

3NKU5

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives

ACIAD1015

lipA

lipoate synthase

COG0320

LIAS_N, Radical_SAM

K03644

3NM04

Nicotinamide mononucleotide transporter

ACIAD1033

putative nucleoside/purine/pyrimidine transport protein (NMN family) (PnuC)

COG3201

NMN_transporter

K03811

3NJXP

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)

ACIAD1062

ppk

polyphosphate kinase

COG0855

PP_kinase, PP_kinase_C, PP_kinase_N

K00937

3NQZY

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

ACIAD1071

cobQ

cobyric acid synthase

COG1492

CbiA, GATase_3

K02232

3NJJG

Sulfate adenylyltransferase subunit 2

ACIAD1072

cysD

sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit)

COG0175

PAPS_reduct

K00957

3NJ0B

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily

ACIAD1073

cysN

ATP-sulfurylase, subunit 1

COG2895

GTP_EFTU

K00956

3NINP

Belongs to the 5-formyltetrahydrofolate cyclo-ligase family

ACIAD1116

folN

5-formyltetrahydrofolate cyclo-ligase

5-FTHF_cyc-lig

FAD binding domain

ubiH

ubiH protein, 2-octaprenyl-6-methoxyphynol hydroxylase, FAD/NAD(P)-binding

FAD_binding_3

Squalene epoxidase

ubiF

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase

FAD_binding_3

3NJVG

Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA

ACIAD1130

putative methyltransferase

COG0313

TP_methylase

K07056

3NIUK

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)

ACIAD1200

putative thiamin-phosphate pyrophosphorylase (ThiE)

COG0352

TMP-TENI

K00788

3NJSW

Glutamate-1-semialdehyde aminotransferase

ACIAD1201

hemL

glutamate-1-semialdehyde aminotransferase

COG0001

Aminotran_3

K01845

1RS1C

GNAT family acetyltransferase

ACIAD1279

cphA

Cyanophycin synthetase

COG1181

Mur_ligase_C, Mur_ligase_M, RimK

K03802

3NIEW

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S

ACIAD1308

thiG

thiamine biosynthesis protein, thiazole moiety

ThiG

ThiS family

thiS

C-terminally thiocarboxylated form is intermediate sulfur donor in thiazole formation; part of ThiF/ThiS complex; complexes with ThiG also

COG2104

ThiS

K03154

3NJWE

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

ACIAD1327

tkrA

Glyoxylate reductase / Glyoxylatereductase / Hydroxypyruvate reductase , 2-ketoaldonate reductase, broad specificity

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00090

3NIW6

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

ACIAD1374

ispU

undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)

COG0020

Prenyltransf

K00806

3NJ8F

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions

ACIAD1391

rraA

Regulator of ribonuclease activity

COG0684

RraA-like

K02553

3NKZM

Homocysteine S-methyltransferase

ACIAD1418

putative homocysteine S-methyltransferase family protein

S-methyl_trans

3NJZH

FAD binding domain

ACIAD1719

pobA

p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3- monooxygenase)

COG0654

FAD_binding_3

K00481

3NT9V

Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity

ACIAD1734

putative methyltransferase (EC 2.1.1.-)

LCM

3NKIE

Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase

ACIAD1754

mdcB

2'-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

COG1767

CitG

K13930

3NN4M

Phosphoribosyl-dephospho-CoA transferase MdcG

ACIAD1758

mdcG

phosphoribosyl-dephospho-CoA transferase (Holo-ACP synthase)

MdcG

K13934

3NKPA

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)

ACIAD1782

ppk

polyphosphate kinase (Polyphosphoric acid kinase) (ATP- polyphosphate phosphotransferase)

COG0855

PP_kinase, PP_kinase_C, PP_kinase_N

K00937

3NK2I

FAD binding domain

ACIAD1808

putative monooxygenase

FAD_binding_3

3NJX7

Probable molybdopterin binding domain

ACIAD1902

moeA

molybdopterin biosynthesis protein

COG0303

MoCF_biosynth, MoeA_C, MoeA_N

K03750

3NKK0

Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)

ACIAD1903

moaCB

bifunctional protein [Includes: molybdenum cofactor biosynthesis protein C; molybdenum cofactor biosynthesis protein B]

MoCF_biosynth, MoaC

3NK9M

Molybdopterin converting factor, large subunit

ACIAD1904

moaE

molybdopterin converting factor, large subunit

MoaE

ThiS family

conserved hypothetical protein

ThiS

3NKDX

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate

ACIAD1906

moaA

molybdopterin biosynthesis, protein A

COG2896

Fer4_12, Mob_synth_C, Radical_SAM

K03639

3NKRG

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor

ACIAD1907

mobA

molybdopterin-guanine dinucleotide synthase

COG0746

NTP_transf_3

K03752

3NMYH

ATP-grasp in the biosynthetic pathway with Ter operon

ACIAD1963

conserved hypothetical protein

ATPgrasp_Ter

3NJIZ

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity

ACIAD1970

dnaX

DNA polymerase III, tau and gamma subunits (DNA elongation factor III)

COG2812

DNA_pol3_delta2, DNA_pol3_gamma3

K02343

3NJ4Q

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

ACIAD1980

tal

transaldolase

COG0176

TAL_FSA

K00616

3NK3F

Belongs to the carbohydrate kinase PfkB family

ACIAD1992

fruK

1-phosphofructokinase

COG1105

PfkB

K00882

3NJ79

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)

ACIAD2011

thiM

hydoxyethylthiazole kinase

COG2145

HK

K00878

3NJFZ

Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme

ACIAD2037

metK

methionine adenosyltransferase

COG1812, COG0192

S-AdoMet_synt_C, S-AdoMet_synt_M, S-AdoMet_synt_N

K00789

3NJJH

Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism

ACIAD2045

bioB

biotin synthetase

COG0502

BATS, Radical_SAM

K01012

3NKIK

Iron-containing redox enzyme

ACIAD2095

conserved hypothetical protein

Haem_oxygenas_2

3NKW9

Aldolase/RraA

ACIAD2118

putative demethylmenaquinone methyltransferase (bfnG)

RraA-like

3NIJZ

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP

ACIAD2231

putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)(PpnK)

COG0061

NAD_kinase

K00858

3NNJP

COG0457 FOG TPR repeat

ACIAD2235

conserved hypothetical protein

3NKK2

Belongs to the Nudix hydrolase family

ACIAD2236

putative bifunctional protein [Includes: dGTP-pyrophosphohydrolase; thiamine phosphate synthase]

COG0494, COG1051

NUDIX, TMP-TENI

K03574

3NKA8

Permease for cytosine/purines, uracil, thiamine, allantoin

putative permease

Transp_cyt_pur

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives

ACIAD2275

lipA

lipoate synthase

COG0320

LIAS_N, Radical_SAM

K03644

3NIJA

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

ACIAD2282

sahH

S-adenosyl-L-homocysteine hydrolase

COG0499

AdoHcyase, AdoHcyase_NAD

K01251

3NIPN

6-pyruvoyl tetrahydropterin synthase

ACIAD2353

putative 6-pyruvoyl-tetrahydropterin synthase

COG0720

PTPS

K01737

3NJ95

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway

ACIAD2392

rbsK

ribokinase

COG0524

PfkB

K00852

3NK47

Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol

ACIAD2405

putative ubiquinone biosynthesis protein

COG2941

COQ7

K06134

3NNNF

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

ACIAD2407

putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

COG0801

HPPK

K00950

3NNI7

Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin

ACIAD2408

folB

dihydroneopterin aldolase

COG1539

FolB

K01633

3NIJ0

COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

ACIAD2411

molybdopterin biosynthesis protein (moeB) OR thiamin-thiazole moiety synthesis (thiF)

COG0476

ThiF

K21029

3NIIN

Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation

ACIAD2422

conserved hypothetical protein

COG1806

Kinase-PPPase

K09773

3NIYC

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate

ACIAD2455

ubiA

4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase)

COG0382

UbiA

K03179

3NKMX

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway

ACIAD2456

ubiC

chorismate pyruvate lyase

Chor_lyase

component II

trpG

bifunctional protein:[Includes: para-aminobenzoate synthase glutamine amidotransferase component II (ADC synthase); anthranilate synthase component II]

GATase

GTP cyclohydrolase

folE

GTP cyclohydrolase I

COG0302

GTP_cyclohydroI

K01495

3NIKI

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

ACIAD2474

hemE

uroporphyrinogen decarboxylase

COG0407

URO-D

K01599

3NMAD

Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ

ACIAD2505

pqqC

coenzyme PQQ synthesis protein C (Coenzyme PQQ synthesis protein I)

COG5424

TENA_THI-4

K06137

3NSYT

Iron-sulfur cluster-binding domain

ACIAD2507

pqqE

coenzyme PQQ synthesis protein E (Coenzyme PQQ synthesis protein III)

COG0535

Fer4_12, Radical_SAM, SPASM

K06139

3NIUI

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

ACIAD2577

pdxJ

Pyridoxine 5'-phosphate synthase

COG0854

PdxJ

K03474

3NJQX

Catalyzes the oxidation of L-aspartate to iminoaspartate

ACIAD2587

nadB

L-aspartate oxidase (quinolinate synthetase B)

COG0029

FAD_binding_2, Succ_DH_flav_C

K00278

3NIK0

Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase

ACIAD2590

pabC

4-amino-4-deoxychorismate lyase

COG0115

Aminotran_4

K02619

3NIYT

Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds

ACIAD2600

putative radical activating enzyme

COG0602

Fer4_14, Radical_SAM

K10026

3NITZ

Cytidylyltransferase-like

ACIAD2606

nadM

nicotinamide/nicotinate-nucleotide adenylyltransferase

CTP_transf_like

3NKB6

Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

ACIAD2667

pdxB

erythronate-4-phosphate dehydrogenase

COG0111

2-Hacid_dh, 2-Hacid_dh_C, DUF3410

K03473

3NMCH

chorismate binding enzyme

ACIAD2776

fbsB

isochorismate synthetase

COG1169

Chorismate_bind

K02361

3NK9R

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle

ACIAD2842

pckG

phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK)

COG1274

PEPCK_C, PEPCK_N

K01596

3NJMW

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives

ACIAD2852

folP

7,8-dihydropteroate synthase

COG0294

Pterin_bind

K00796

3NIYF

Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source

ACIAD2888

nadE

NAD synthetase, NH3/glutamine-dependent

COG0388, COG0171

CN_hydrolase, NAD_synthase

K01950

3NJTZ

Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

ACIAD2893

coaD

phosphopantetheine adenylyltransferase

COG0669

CTP_transf_like

K00954

3NJ4K

Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

ACIAD2900

hemA

glutamyl tRNA reductase

COG0373

GlutR_N, GlutR_dimer, Shikimate_DH

K02492

3NN4I

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine

ACIAD2911

panD

aspartate 1-decarboxylase precursor

COG0853

Asp_decarbox

K01579

3NIMM

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

ACIAD2913

ribB

3,4 dihydroxy-2-butanone-4-phosphate synthase

COG0108

DHBP_synthase

K02858

3NIWJ

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

ACIAD2927

lipB

lipoate-protein ligase B (Lipoate biosynthesis protein B)

COG0321

BPL_LplA_LipB

K03801

3NISX

Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme

ACIAD2934

cysG

multifunctional protein [Includes: Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2 oxidase ; Ferrochelatase ] (Siroheme synthase)

COG0007, COG1648

CysG_dimeriser, NAD_binding_7, TP_methylase

K02302

3NK0C

Belongs to the FPP GGPP synthase family

ACIAD2940

ispB

octaprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase) (OPP synthetase)

COG0142

polyprenyl_synt

K02523

3NK6Z

Belongs to the FPP GGPP synthase family

ACIAD2968

ispA

geranyltranstransferase (farnesyldiphosphate synthase) (FPP synthase)

COG0142

polyprenyl_synt

K00795

3NIRN

Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

ACIAD3010

pdxA

4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)

COG1995

PdxA

K00097

3NJJJ

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

ACIAD3060

panC

pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)

COG0414

Pantoate_ligase

K01918

3NIP8

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate

ACIAD3061

panB

3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase)

COG0413

Pantoate_transf

K00606

3NNAE

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

ACIAD3062

folK

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK)

COG0801

HPPK

K00950

3NIH2

COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1

ACIAD3088

putative tRNA threonylcarbamoyladenosine dehydratase (tcdA)

COG1179

ThiF

K22132

3NIUP

Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate

ACIAD3102

ilvC

acetohydroxy acid isomeroreductase and 2-dehydropantoate 2-reductase

COG0059

IlvC, IlvN

K00053

3NJ1B

acetolactate synthase

ACIAD3104

ilvI

acetolactate synthase III, large subunit

COG0028

TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N

K01652

3NJ8G

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

ACIAD3125

dfp

bifunctional protein [Includes: 4'-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding]

COG0452

DFP, Flavoprotein

K13038

3NJ9J

Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34

ACIAD3135

putative tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC

COG4121, COG0665

DAO, Methyltransf_30

K15461

3NIWY

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

ACIAD3247

dxs

1-deoxyxylulose-5-phosphate synthase

COG1154

DXP_synthase_N, Transket_pyr, Transketolase_C

K01662

3NJJB

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

ACIAD3249

ribA

GTP cyclohydrolase II

COG0807

GTP_cyclohydro2

K01497

3NJJ9

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX

ACIAD3250

hemF

coproporphyrinogen III oxidase

COG0408

Coprogen_oxidas

K00228

3NJ4U

Catalyzes the ferrous insertion into protoporphyrin IX

ACIAD3255

hemH

ferrochelatase

COG0276

Ferrochelatase

K01772

3NJ61

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

ACIAD3278

hprA

glycerate dehydrogenase

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00018

3NINV

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

ACIAD3302

serA

D-3-phosphoglycerate dehydrogenase

COG0111

2-Hacid_dh, 2-Hacid_dh_C

K00058

3NJ7P

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

ACIAD3501

pdxH

pyridoxamine 5'-phosphate oxidase (acts also on pyridoxine phosphate and pyridoxine)

COG0259

PNP_phzG_C, Putative_PNPOx

K00275

3NIX2

Belongs to the prokaryotic GSH synthase family

ACIAD3518

gshB

glutathione synthetase

GSH-S_ATP, GSH-S_N

FAD binding domain

hpxO

FAD-dependent urate oxidase

FAD_binding_3

K16839

3NK8B

Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily

ACIAD3549

gshA

gamma-glutamate-cysteine ligase

COG2918

Glu_cys_ligase

K01919

3NJ8E

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

ACIAD3570

ribB/A

bifunctional protein [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II]

COG0108, COG0807

DHBP_synthase, GTP_cyclohydro2

K14652

3NIEQ

Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin

ACIAD3571

ribH

6,7-dimethyl-8-ribityllumazine synthase (Lumazine synthase)(riboflavin synthase beta chain)

COG0054

DMRL_synthase

K00794

3NKDN

Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1

ACIAD3573

thiL

thiamin-monophosphate kinase

COG0611