Genomic Tools

OG ID	OG function	Label	Gene	Product	COG	PFAM short name	KO
3NJF2	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	ACIAD0011	anmK	Anhydro-N-acetylmuramic acid kinase (AnhMurNAc kinase)	COG2377	AnmK	K09001
3NJWC	5'-nucleotidase, C-terminal domain	ACIAD0015		putative 5'-nucleotidase NucA precursor	COG0737	5_nucleotid_C, Metallophos	K11751
3NJBQ	Permease family	ACIAD0031	rutG	Putative pyrimidine permease rutG (Pyrimidine utilization protein G)		Xan_ur_permease
3NR0W	Permease family	ACIAD0136		putative xanthine/uracil permease		Xan_ur_permease
3NKU6	Amidohydrolase family	ACIAD0137		putative midohydrolase-related domain-containing protein		Amidohydro_1
3NJGP	Catalyzes the synthesis of GMP from XMP	ACIAD0151	guaA	GMP synthetase (glutamine aminotransferase)	COG0518, COG0519	GATase, GMP_synt_C, NAD_synthase	K01951
3NSRJ	MafB19-like deaminase	ACIAD0204		putative cytidine and deoxycytidylate deaminase zinc-binding like protein		dCMP_cyt_deam_1
3NKD9	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	ACIAD0505	purU1	formyltetrahydrofolate deformylase	COG0788	ACT, Formyl_trans_N	K01433
3NKAC	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	ACIAD0515	thyA	thymidylate synthase (TS) (TSase)	COG0207	Thymidylat_synt	K00560
3NJHQ	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ACIAD0526		putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1)	COG0127	Ham1p_like	K02428
3NMP4	AAA domain	ACIAD0545	gntK	thermoresistant gluconokinase (Gluconate kinase)	COG3265	SKI	K00851
3NK6T	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ACIAD0556	ndk	nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)	COG0105	NDK	K00940
3NK2U	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	ACIAD0590	tgt	queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme)	COG0343	TGT	K00773
3NJ77	Nudix N-terminal	ACIAD0673		putative MutT/nudix family protein		NUDIX, Nudix_N_2
3NIRB	Permease family	ACIAD0702		putative transporter	COG2233	Xan_ur_permease	K16345
3NIY6	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	ACIAD0722	nrdB	ribonucleoside-diphosphate reductase, beta subunit	COG0208	Ribonuc_red_sm	K00526
3NJ81	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	ACIAD0724	nrdA	ribonucleoside diphosphate reductase, alpha subunit	COG0209	ATP-cone, Ribonuc_red_lgC, Ribonuc_red_lgN	K00525
3NISU	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	ACIAD0744	upp	uracil phosphoribosyltransferase	COG0035	UPRTase	K00761
3NT47	Amidohydrolase family	ACIAD0761		8-oxoguanine deaminase	COG0402	Amidohydro_1	K18456
3NIND	Permease family	ACIAD0762		putative permease		Xan_ur_permease
3NIHF	Phosphorylase superfamily	ACIAD0773		putative MTA/SAH nucleosidase [Includes: 5'-methylthioadenosine nucleosidase ; S-adenosylhomocysteine nucleosidase]	COG0775	PNP_UDP_1	K01243
3NKH3	Belongs to the dCTP deaminase family	ACIAD0776	dcd	deoxycytidine triphosphate deaminase	COG0717	dUTPase	K01494
3NJKW	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	ACIAD0840	coaX	Type III pantothenate kinase (PanK-III)	COG1521	Pan_kinase	K03525
3NJH4	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	ACIAD0901	dut	deoxyuridine 5'-triphosphate nucleotidohydrolase	COG0756	dUTPase	K01520
3NIRX	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	ACIAD0930	glpK	glycerol kinase	COG0554	FGGY_C, FGGY_N	K00864
3NTMH	NUDIX domain	ACIAD0962	nrtR	NAD-related transcriptional regulator		NUDIX
3NK4G	Phosphoribosyl synthetase-associated domain	ACIAD0964	prs	ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase)	COG0462	Pribosyltran	K00948
3NINB	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	ACIAD1105	adk	adenylate kinase	COG0563	ADK, ADK_lid	K00939
3NK3G	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	ACIAD1150	pyrC	dihydroorotase	COG0418, COG0044	Amidohydro_1	K01465
3NIZU	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	ACIAD1219	purB	adenylosuccinate lyase	COG0015	ASL_C, Lyase_1	K01756
3NIQI	Belongs to the Nudix hydrolase family. NudJ subfamily	ACIAD1222		putative Nudix hydrolase		NUDIX
3NJMF	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	ACIAD1245	add	adenosine deaminase	COG1816	A_deaminase	K21053
3NJVH	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	ACIAD1258	purA	adenylosuccinate synthetase	COG0104	Adenylsucc_synt	K01939
3NJN7	Belongs to the ATCase OTCase family	ACIAD1270	pyrB	aspartate carbamoyltransferase, catalytic subunit	COG0540	OTCace, OTCace_N	K00609
3NJ58	dihydroorotase	ACIAD1271	pyrX	aspartate carbamoyltransferase, non-catalytic chain (Dihydroorotase-like protein)	COG0418, COG0044	Amidohydro_1	K01465
3NIRQ	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	ACIAD1321	pyrD	dihydroorotate oxydase		DHO_dh	K00254
3NJRY	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	ACIAD1323	purF	amidophosphoribosyltransferase	COG0034	GATase_6, Pribosyltran	K00764
3NK7K	Catalyzes the reversible phosphorylation of UMP to UDP	ACIAD1372	pyrH	uridylate kinase	COG0528	AA_kinase	K09903
3NIYJ	HIT domain	ACIAD1396		conserved hypothetical protein		HIT
3NMEC	Amidohydrolase family	ACIAD1419		putative dihydroorotase	COG0418, COG0044	Amidohydro_1	K01465
3NKU6	Amidohydrolase family	ACIAD1467		putative hydrolase protein		Amidohydro_1
3NIY1	Adenylosuccinate lyase C-terminus	ACIAD1707	pcaB	3-carboxy-cis,cis-muconate cycloisomerase (3-carboxymuconate lactonizing enzyme) (CMLE)	COG0015	ADSL_C, Lyase_1	K01857
3NIZZ	Belongs to the phosphoglycerate kinase family	ACIAD1927	pgk	phosphoglycerate kinase	COG0126	PGK	K00927
3NK4A	Phosphoribosyl transferase	ACIAD1962		conserved hypothetical protein		PRTase_2, TRSP
3NIZ5	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	ACIAD2003	pyrG	CTP synthase	COG0504	CTP_synth_N, GATase	K01937
3NJAH	Glutamine amidotransferase class-I	ACIAD2019		putative glutamine amidotransferase	COG0518, COG0519	GATase	K01951
3NIGI	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	ACIAD2078	purT	phosphoribosylglycinamide formyltransferase 2	COG0027	ATP-grasp	K08289
3NKK2	Belongs to the Nudix hydrolase family	ACIAD2236		putative bifunctional protein [Includes: dGTP-pyrophosphohydrolase; thiamine phosphate synthase]	COG0494, COG1051	NUDIX, TMP-TENI	K03574
3NKA8	Permease for cytosine/purines, uracil, thiamine, allantoin	ACIAD2247		putative permease	COG1953, COG1457	Transp_cyt_pur	K03457
3NN34	Scavenger mRNA decapping enzyme C-term binding	ACIAD2318		putative histidine triad family protein	COG0537	HIT	K02503
3NKE2	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	ACIAD2341	pyrF	orotidine-5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase)	COG0284	OMPdecase	K01591
3NKW2	Belongs to the cytidylate kinase family. Type 1 subfamily	ACIAD2348	cmk	cytidylate kinase (cytidine monophosphate (CMP) kinase)	COG0283	Cytidylate_kin	K00945
3NN6N	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	ACIAD2350		putative deaminase		MafB19-deam
3NJ8H	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	ACIAD2374	miaA	delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase	COG0324	IPPT	K00791
3NJ4P	Bifunctional purine biosynthesis protein PurH	ACIAD2447	purH	bifunctional protein [Includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]	COG0138	AICARFT_IMPCHas, MGS	K00602
3NJ3Q	Belongs to the GARS family	ACIAD2448	purD	phosphoribosylamine--glycine ligase (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase)	COG0151	GARS_A, GARS_C, GARS_N	K01945
3NKF4	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	ACIAD2467	xdhB	xanthine dehydrogenase, large subunit	COG4631	Ald_Xan_dh_C, Ald_Xan_dh_C2	K13482
3NMU6	CO dehydrogenase flavoprotein C-terminal domain	ACIAD2468	xdhA	xanthine dehydrogenase, small subunit	COG4630	CO_deh_flav_C, FAD_binding_5, Fer2_2	K13481
3NKRZ	Belongs to the purine-cytosine permease (2.A.39) family	ACIAD2502		conserved hypothetical protein; putative membrane protein
3NM13	Glutamine amidotransferase domain	ACIAD2527	mgsA	putative N-methyl glutamate synthase subunit A		GATase_6	K22081
3NKKE	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	ACIAD2553	folD	bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase]	COG0190	THF_DHG_CYH, THF_DHG_CYH_C	K01491
3NIE9	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	ACIAD2554	purU	formyltetrahydrofolate deformylase	COG0788	Formyl_trans_N	K01433
3NJAF	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	ACIAD2576		conserved hypothetical protein; putative tRNA hydroxylase	COG4445	MiaE	K06169
3NM7P	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	ACIAD2588	tmk	thymidylate kinase	COG0125	Thymidylate_kin	K00943
3NKQJ	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	ACIAD2601	queC	Queuosine biosynthesis protein queC	COG0603	QueC	K06920
3NK3W	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	ACIAD2612	purL	phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase)	COG0046, COG0047	AIRS_C, GATase_5	K01952
3NJF5	Deoxyguanosinetriphosphate triphosphohydrolase-like protein	ACIAD2613	dgt	deoxyguanosinetriphosphate triphosphohydrolase (dGTPase) (dGTP triphosphohydrolase)	COG0232	HD	K01129
3NJMQ	Phosphoribosylformylglycinamidine cyclo-ligase	ACIAD2634	purM	phosphoribosylaminoimidazole synthetase	COG0150	AIRS, AIRS_C	K01933
3NJPI	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	ACIAD2635	purN	phosphoribosylglycinamide formyltransferase 1	COG0299	Formyl_trans_N	K11175
3NIEZ	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	ACIAD2847	folD	bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase]	COG0190	THF_DHG_CYH, THF_DHG_CYH_C	K01491
3NJIR	Belongs to the CarA family	ACIAD2860	carA	carbamoyl-phosphate synthase, small chain	COG0505	CPSase_sm_chain, GATase	K01956
3NIFC	Carbamoyl-phosphate synthetase ammonia chain	ACIAD2861	carB	carbamoyl-phosphate synthase, large subunit	COG0458	CPSase_L_D2, CPSase_L_D3, MGS	K01955
3NJCK	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	ACIAD2873	sucC	succinyl-CoA synthetase beta chain	COG0045	ATP-grasp_2, Ligase_CoA	K01903
3NJU8	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ACIAD2903	ispE	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	COG1947	GHMP_kinases_C, GHMP_kinases_N	K00919
3NIWP	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	ACIAD2907	prs	ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase)	COG0462	Pribosyl_synth, Pribosyltran_N	K00948
3NMM7	AAA domain	ACIAD2987		conserved hypothetical protein; putative kinase
3NIV4	Belongs to the GppA Ppx family	ACIAD3036	ppx	exopolyphosphatase (ExopolyPase) (Metaphosphatase)	COG0248	HD, Ppx-GppA	K01524
3NPQP	Phosphorylase superfamily	ACIAD3146	mtnN	methylthioadenosine / S-adenosylhomocysteine nucleosidase	COG0775	PNP_UDP_1	K01243
3NJDE	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	ACIAD3164	xpt	xanthine phosphoribosyltransferase	COG0503	Pribosyltran	K03816
3NK9A	Glutamine amidotransferase class-I	ACIAD3221		conserved hypothetical protein; putative glutamine amidotransferase		GATase
3NNGI	NUDIX domain	ACIAD3237		conserved hypothetical protein; putative MutT/nudix family protein	COG0494, COG1051	NUDIX	K03574
3NIH0	Endonuclease related to archaeal Holliday junction resolvase	ACIAD3286		conserved hypothetical protein		Endonuc_Holl
3NMDQ	MafB19-like deaminase	ACIAD3297		putative cytidine / deoxycytidylate deaminase family protein		dCMP_cyt_deam_1
3NKHV	Essential for recycling GMP and indirectly, cGMP	ACIAD3324	gmk	guanylate kinase	COG0194	Guanylate_kin	K00942
3NJ5H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	ACIAD3354	aroK	shikimate-kinase	COG0703	SKI	K00891
3NJ98	Belongs to the pseudomonas-type ThrB family	ACIAD3403		putative homoserine kinase (ThrB)	COG2334	APH	K02204
3NKFZ	DNA RNA non-specific endonuclease	ACIAD3408		putative DNA/RNA non-specific endonuclease G protein	COG1864	Endonuclease_NS	K01173
3NJ7U	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	ACIAD3503	guaB	IMP dehydrogenase	COG0516, COG0517	CBS, IMPDH	K00088
3NJ01	Belongs to the D-alanine--D-alanine ligase family	ACIAD3515	ddlB	D-alanine-D-alanine ligase B	COG1181	Dala_Dala_lig_C, Dala_Dala_lig_N	K01921
3NK81	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	ACIAD3525	pyrE	orotate phosphoribosyltransferase	COG0461	Pribosyltran	K00762
3NKYH	Belongs to the allantoicase family	ACIAD3541	alc	allantoicase		Allantoicase	K01477
3NKSW	Ureidoglycolate lyase	ACIAD3542	allA	ureidoglycolate amidohydrolase	COG3194	Ureidogly_lyase	K01483
3NIZE	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	ACIAD3562	pncB	nicotinate phosphoribosyltransferase	COG1488	NAPRTase	K00763
3NJE6	Belongs to the SAICAR synthetase family	ACIAD3587	purC	phosphoribosylaminoimidazole-succinocarboxamide synthase	COG0152	SAICAR_synt	K01923
3NNPS	Protein similar to CwfJ C-terminus 1	ACIAD3604		putative histidine triad family protein		HIT
3NJBQ	Permease family	ACIAD3628		putative uracil transport protein (NCS2 family)		Xan_ur_permease
3NJV0	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	ACIAD3658	purK	phosphoribosylaminoimidazole carboxylase ATPase subunit	COG0026	ATP-grasp	K01589
3NIR5	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	ACIAD3659	purE	phosphoribosylaminoimidazole carboxylase, mutase subunit	COG0041	AIRC	K01588
3NJ8T	Amidohydrolase family	ACIAD3668	guaD	guanine deaminase	COG0402	Amidohydro_1	K01487
3NK0V	Belongs to the purine pyrimidine phosphoribosyltransferase family	ACIAD3669	hpt	hypoxanthine phosphoribosyltransferase	COG0634	Pribosyltran	K00760

3NJF2

Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling

ACIAD0011

anmK

Anhydro-N-acetylmuramic acid kinase (AnhMurNAc kinase)

COG2377

AnmK

K09001

3NJWC

5'-nucleotidase, C-terminal domain

ACIAD0015

putative 5'-nucleotidase NucA precursor

COG0737

5_nucleotid_C, Metallophos

K11751

3NJBQ

Permease family

ACIAD0031

rutG

Putative pyrimidine permease rutG (Pyrimidine utilization protein G)

Xan_ur_permease

3NR0W

Permease family

ACIAD0136

putative xanthine/uracil permease

Xan_ur_permease

3NKU6

Amidohydrolase family

ACIAD0137

putative midohydrolase-related domain-containing protein

Amidohydro_1

3NJGP

Catalyzes the synthesis of GMP from XMP

ACIAD0151

guaA

GMP synthetase (glutamine aminotransferase)

COG0518, COG0519

GATase, GMP_synt_C, NAD_synthase

K01951

3NSRJ

MafB19-like deaminase

ACIAD0204

putative cytidine and deoxycytidylate deaminase zinc-binding like protein

dCMP_cyt_deam_1

3NKD9

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)

ACIAD0505

purU1

formyltetrahydrofolate deformylase

COG0788

ACT, Formyl_trans_N

K01433

3NKAC

Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis

ACIAD0515

thyA

thymidylate synthase (TS) (TSase)

COG0207

Thymidylat_synt

K00560

3NJHQ

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions

ACIAD0526

putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1)

Ham1p_like

AAA domain

gntK

thermoresistant gluconokinase (Gluconate kinase)

COG3265

SKI

K00851

3NK6T

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

ACIAD0556

ndk

nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)

COG0105

NDK

K00940

3NK2U

Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)

ACIAD0590

tgt

queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme)

TGT

Nudix N-terminal

putative MutT/nudix family protein

NUDIX, Nudix_N_2

Permease family

putative transporter

Xan_ur_permease

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

ACIAD0722

nrdB

ribonucleoside-diphosphate reductase, beta subunit

COG0208

Ribonuc_red_sm

K00526

3NJ81

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

ACIAD0724

nrdA

ribonucleoside diphosphate reductase, alpha subunit

COG0209

ATP-cone, Ribonuc_red_lgC, Ribonuc_red_lgN

K00525

3NISU

Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

ACIAD0744

upp

uracil phosphoribosyltransferase

COG0035

UPRTase

K00761

3NT47

Amidohydrolase family

ACIAD0761

8-oxoguanine deaminase

Amidohydro_1

Permease family

putative permease

Xan_ur_permease

3NIHF

Phosphorylase superfamily

ACIAD0773

putative MTA/SAH nucleosidase [Includes: 5'-methylthioadenosine nucleosidase ; S-adenosylhomocysteine nucleosidase]

COG0775

PNP_UDP_1

K01243

3NKH3

Belongs to the dCTP deaminase family

ACIAD0776

dcd

deoxycytidine triphosphate deaminase

COG0717

dUTPase

K01494

3NJKW

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

ACIAD0840

coaX

Type III pantothenate kinase (PanK-III)

COG1521

Pan_kinase

K03525

3NJH4

This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

ACIAD0901

dut

deoxyuridine 5'-triphosphate nucleotidohydrolase

COG0756

dUTPase

K01520

3NIRX

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate

ACIAD0930

glpK

glycerol kinase

FGGY_C, FGGY_N

NUDIX domain

nrtR

NAD-related transcriptional regulator

NUDIX

3NK4G

Phosphoribosyl synthetase-associated domain

ACIAD0964

prs

ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase)

COG0462

Pribosyltran

K00948

3NINB

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism

ACIAD1105

adk

adenylate kinase

COG0563

ADK, ADK_lid

K00939

3NK3G

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate

ACIAD1150

pyrC

dihydroorotase

COG0418, COG0044

Amidohydro_1

K01465

3NIZU

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily

ACIAD1219

purB

adenylosuccinate lyase

COG0015

ASL_C, Lyase_1

K01756

3NIQI

Belongs to the Nudix hydrolase family. NudJ subfamily

ACIAD1222

putative Nudix hydrolase

NUDIX

3NJMF

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism

ACIAD1245

add

adenosine deaminase

COG1816

A_deaminase

K21053

3NJVH

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

ACIAD1258

purA

adenylosuccinate synthetase

COG0104

Adenylsucc_synt

K01939

3NJN7

Belongs to the ATCase OTCase family

ACIAD1270

pyrB

aspartate carbamoyltransferase, catalytic subunit

OTCace, OTCace_N

dihydroorotase

pyrX

aspartate carbamoyltransferase, non-catalytic chain (Dihydroorotase-like protein)

COG0418, COG0044

Amidohydro_1

K01465

3NIRQ

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor

ACIAD1321

pyrD

dihydroorotate oxydase

DHO_dh

K00254

3NJRY

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine

ACIAD1323

purF

amidophosphoribosyltransferase

COG0034

GATase_6, Pribosyltran

K00764

3NK7K

Catalyzes the reversible phosphorylation of UMP to UDP

ACIAD1372

pyrH

uridylate kinase

AA_kinase

HIT domain

conserved hypothetical protein

HIT

3NMEC

Amidohydrolase family

ACIAD1419

putative dihydroorotase

COG0418, COG0044

Amidohydro_1

K01465

3NKU6

Amidohydrolase family

ACIAD1467

putative hydrolase protein

Amidohydro_1

3NIY1

Adenylosuccinate lyase C-terminus

ACIAD1707

pcaB

3-carboxy-cis,cis-muconate cycloisomerase (3-carboxymuconate lactonizing enzyme) (CMLE)

COG0015

ADSL_C, Lyase_1

K01857

3NIZZ

Belongs to the phosphoglycerate kinase family

ACIAD1927

pgk

phosphoglycerate kinase

COG0126

PGK

K00927

3NK4A

Phosphoribosyl transferase

ACIAD1962

conserved hypothetical protein

PRTase_2, TRSP

3NIZ5

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates

ACIAD2003

pyrG

CTP synthase

COG0504

CTP_synth_N, GATase

K01937

3NJAH

Glutamine amidotransferase class-I

ACIAD2019

putative glutamine amidotransferase

COG0518, COG0519

GATase

K01951

3NIGI

Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate

ACIAD2078

purT

phosphoribosylglycinamide formyltransferase 2

COG0027

ATP-grasp

K08289

3NKK2

Belongs to the Nudix hydrolase family

ACIAD2236

putative bifunctional protein [Includes: dGTP-pyrophosphohydrolase; thiamine phosphate synthase]

COG0494, COG1051

NUDIX, TMP-TENI

K03574

3NKA8

Permease for cytosine/purines, uracil, thiamine, allantoin

putative permease

Transp_cyt_pur

Scavenger mRNA decapping enzyme C-term binding

ACIAD2318

putative histidine triad family protein

COG0537

HIT

K02503

3NKE2

Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

ACIAD2341

pyrF

orotidine-5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase)

COG0284

OMPdecase

K01591

3NKW2

Belongs to the cytidylate kinase family. Type 1 subfamily

ACIAD2348

cmk

cytidylate kinase (cytidine monophosphate (CMP) kinase)

COG0283

Cytidylate_kin

K00945

3NN6N

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)

ACIAD2350

putative deaminase

MafB19-deam

3NJ8H

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

ACIAD2374

miaA

delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase

COG0324

IPPT

K00791

3NJ4P

Bifunctional purine biosynthesis protein PurH

ACIAD2447

purH

bifunctional protein [Includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]

COG0138

AICARFT_IMPCHas, MGS

K00602

3NJ3Q

Belongs to the GARS family

ACIAD2448

purD

phosphoribosylamine--glycine ligase (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase)

COG0151

GARS_A, GARS_C, GARS_N

K01945

3NKF4

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

ACIAD2467

xdhB

xanthine dehydrogenase, large subunit

COG4631

Ald_Xan_dh_C, Ald_Xan_dh_C2

K13482

3NMU6

CO dehydrogenase flavoprotein C-terminal domain

ACIAD2468

xdhA

xanthine dehydrogenase, small subunit

COG4630

CO_deh_flav_C, FAD_binding_5, Fer2_2

K13481

3NKRZ

Belongs to the purine-cytosine permease (2.A.39) family

ACIAD2502

conserved hypothetical protein; putative membrane protein

3NM13

Glutamine amidotransferase domain

ACIAD2527

mgsA

putative N-methyl glutamate synthase subunit A

GATase_6

K22081

3NKKE

Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

ACIAD2553

folD

bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase]

COG0190

THF_DHG_CYH, THF_DHG_CYH_C

K01491

3NIE9

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)

ACIAD2554

purU

formyltetrahydrofolate deformylase

COG0788

Formyl_trans_N

K01433

3NJAF

tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)

ACIAD2576

conserved hypothetical protein; putative tRNA hydroxylase

COG4445

MiaE

K06169

3NM7P

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

ACIAD2588

tmk

thymidylate kinase

COG0125

Thymidylate_kin

K00943

3NKQJ

Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))

ACIAD2601

queC

Queuosine biosynthesis protein queC

COG0603

QueC

K06920

3NK3W

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate

ACIAD2612

purL

phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase)

COG0046, COG0047

AIRS_C, GATase_5

K01952

3NJF5

Deoxyguanosinetriphosphate triphosphohydrolase-like protein

ACIAD2613

dgt

deoxyguanosinetriphosphate triphosphohydrolase (dGTPase) (dGTP triphosphohydrolase)

COG0232

HD

K01129

3NJMQ

Phosphoribosylformylglycinamidine cyclo-ligase

ACIAD2634

purM

phosphoribosylaminoimidazole synthetase

COG0150

AIRS, AIRS_C

K01933

3NJPI

Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate

ACIAD2635

purN

phosphoribosylglycinamide formyltransferase 1

COG0299

Formyl_trans_N

K11175

3NIEZ

Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

ACIAD2847

folD

bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase]

COG0190

THF_DHG_CYH, THF_DHG_CYH_C

K01491

3NJIR

Belongs to the CarA family

ACIAD2860

carA

carbamoyl-phosphate synthase, small chain

COG0505

CPSase_sm_chain, GATase

K01956

3NIFC

Carbamoyl-phosphate synthetase ammonia chain

ACIAD2861

carB

carbamoyl-phosphate synthase, large subunit

COG0458

CPSase_L_D2, CPSase_L_D3, MGS

K01955

3NJCK

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit

ACIAD2873

sucC

succinyl-CoA synthetase beta chain

COG0045

ATP-grasp_2, Ligase_CoA

K01903

3NJU8

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

ACIAD2903

ispE

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)

COG1947

GHMP_kinases_C, GHMP_kinases_N

K00919

3NIWP

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)

ACIAD2907

prs

ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase)

COG0462

Pribosyl_synth, Pribosyltran_N

K00948

3NMM7

AAA domain

ACIAD2987

conserved hypothetical protein; putative kinase

3NIV4

Belongs to the GppA Ppx family

ACIAD3036

ppx

exopolyphosphatase (ExopolyPase) (Metaphosphatase)

COG0248

HD, Ppx-GppA

K01524

3NPQP

Phosphorylase superfamily

ACIAD3146

mtnN

methylthioadenosine / S-adenosylhomocysteine nucleosidase

COG0775

PNP_UDP_1

K01243

3NJDE

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

ACIAD3164

xpt

xanthine phosphoribosyltransferase

COG0503

Pribosyltran

K03816

3NK9A

Glutamine amidotransferase class-I

ACIAD3221

conserved hypothetical protein; putative glutamine amidotransferase

GATase

3NNGI

NUDIX domain

ACIAD3237

conserved hypothetical protein; putative MutT/nudix family protein

COG0494, COG1051

NUDIX

K03574

3NIH0

Endonuclease related to archaeal Holliday junction resolvase

ACIAD3286

conserved hypothetical protein

Endonuc_Holl

3NMDQ

MafB19-like deaminase

ACIAD3297

putative cytidine / deoxycytidylate deaminase family protein

dCMP_cyt_deam_1

3NKHV

Essential for recycling GMP and indirectly, cGMP

ACIAD3324

gmk

guanylate kinase

COG0194

Guanylate_kin

K00942

3NJ5H

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

ACIAD3354

aroK

shikimate-kinase

COG0703

SKI

K00891

3NJ98

Belongs to the pseudomonas-type ThrB family

ACIAD3403

putative homoserine kinase (ThrB)

COG2334

APH

K02204

3NKFZ

DNA RNA non-specific endonuclease

ACIAD3408

putative DNA/RNA non-specific endonuclease G protein

COG1864

Endonuclease_NS

K01173

3NJ7U

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth

ACIAD3503

guaB

IMP dehydrogenase

COG0516, COG0517

CBS, IMPDH

K00088

3NJ01

Belongs to the D-alanine--D-alanine ligase family

ACIAD3515

ddlB

D-alanine-D-alanine ligase B

COG1181

Dala_Dala_lig_C, Dala_Dala_lig_N

K01921

3NK81

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

ACIAD3525

pyrE

orotate phosphoribosyltransferase

COG0461

Pribosyltran

K00762

3NKYH

Belongs to the allantoicase family

ACIAD3541

alc

allantoicase

Allantoicase