Genomic Tools

OG ID	OG function	Label	Gene	Product	COG	PFAM short name	KO
3NNK9	Iron-sulfur cluster insertion protein ErpA	ACIAD0010		putative chaperone involved in Fe-S cluster assembly and activation (HesB-like)	COG0316	Fe-S_biosyn	K15724
3NJKB	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate	ACIAD0027	rutA	Putative Pyrimidine monooxygenase rutA (Pyrimidine utilization protein A)	COG2141	Bac_luciferase	K09018
3NNA1	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway	ACIAD0030	rutF	putative FMN reductase (NADH) RutF (Pyrimidine utilization protein F)	COG1853	Flavin_Reduct	K09024
3NITN	Catalyzes the desulfonation of aliphatic sulfonates	ACIAD0036	ssuD	FMNH(2)-dependent alkanesulfonate monooxygenase	COG2141	Bac_luciferase	K04091
3NK4F	Oxidoreductase NAD-binding domain	ACIAD0048		putative oxidoreductase		FAD_binding_6, Fer2, NAD_binding_1
3NJK8	L-lactate permease	ACIAD0106	lldP	L-lactate permease	COG1620	Lactate_perm	K00427
3NJCA	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain	ACIAD0108	lldD	L-lactate dehydrogenase, FMN linked	COG1304	FMN_dh	K00101
3NIS1	Catalyzes the oxidation of D-lactate to pyruvate	ACIAD0109	dld	D-lactate dehydrogenase, NADH independent, FAD-binding domain	COG0277	FAD_binding_4, Lact-deh-memb	K03777
3NITY	Oxidative deamination of D-amino acids	ACIAD0115	dadA	D-amino acid dehydrogenase, small subunit	COG0665	DAO	K00285
3NM93	Aldehyde dehydrogenase family	ACIAD0131		2-ketoglutarate semialdehyde dehydrogenase		Aldedh	K13877
3NM6Z	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ACIAD0133		putative 2-hydroxyacid dehydrogenase	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00018
3NIZP	malate dehydrogenase (decarboxylating) (NAD+) activity	ACIAD0166	sfcA	NAD-linked malate dehydrogenase, Rossman fold	COG0281	Malic_M, malic	K00027
3NNM6	ATP synthase I chain	ACIAD0178	atpI	ATP synthase protein I	COG3312	ATP-synt_I	K02116
3NJCY	it plays a direct role in the translocation of protons across the membrane	ACIAD0180	atpB	membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly	COG0356	ATP-synt_A	K02108
3NPA2	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	ACIAD0182	atpE	membrane-bound ATP synthase, F0 sector, subunit c		ATP-synt_C
3NJBM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	ACIAD0183	atpF	membrane-bound ATP synthase, F0 sector, subunit b	COG0711	ATP-synt_B	K02109
3NIHZ	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	ACIAD0184	atpH	membrane-bound ATP synthase , F1 sector, delta-subunit	COG0712	OSCP	K02113
3NJ2E	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	ACIAD0185	atpA	membrane-bound ATP synthase , F1 sector, alpha-subunit	COG0056	ATP-synt_ab, ATP-synt_ab_C, ATP-synt_ab_N	K02111
3NJVA	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	ACIAD0186	atpG	membrane-bound ATP synthase , F1 sector, gamma-subunit	COG0224	ATP-synt	K02115
3NK1R	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	ACIAD0187	atpD	membrane-bound ATP synthase , F1 sector, beta-subunit	COG0055	ATP-synt_ab, ATP-synt_ab_N	K02112
3NN50	Produces ATP from ADP in the presence of a proton gradient across the membrane	ACIAD0188	atpC	membrane-bound ATP synthase , F1 sector, epsilon-subunit	COG0355	ATP-synt_DE_N	K02114
3NJH5	UPF0313 protein	ACIAD0220		putative UPF0313 SAM protein		DUF3362, Radical_SAM, Radical_SAM_N
3NJX9	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ACIAD0239	ppa	inorganic pyrophosphatase	COG0221	Pyrophosphatase	K01507
3NP04	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	ACIAD0282		Putative Fe(2+)-trafficking protein (yggX-like)		Iron_traffic
3NIJN	Proton-conducting membrane transporter	ACIAD0374	phaD	pH adaptation potassium efflux system D transmembrane protein	COG0651	Proton_antipo_M	K05561
3NIM9	Domain related to MnhB subunit of Na+/H+ antiporter	ACIAD0376	phaAB	pH adaptation potassium efflux system transmembrane protein	COG1009	DUF4040, MnhB, Proton_antipo_M, Proton_antipo_N	K05559
3NIMA	FAD binding domain	ACIAD0381		putative oxidoreductase; putative flavoprotein monooxygenase		FAD_binding_3
3NJBI	serves to protect cells from the toxic effects of hydrogen peroxide	ACIAD0451	katA	catalase (hydroperoxidase II)	COG0753	Catalase, Catalase-rel	K03781
3NK2W	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	ACIAD0469	leuB	3-isopropylmalate dehydrogenase	COG0473	Iso_dh	K00052
3NJP9	belongs to the aldehyde dehydrogenase family	ACIAD0503	calB	coniferyl aldehyde dehydrogenase (CALDH)	COG1012	Aldedh	K00154
3NJSC	Catalyzes the reversible hydration of fumarate to (S)- malate	ACIAD0538	fumA	fumarate hydratase	COG1838, COG1951	Fumerase, Fumerase_C	K01676
3NJD4	belongs to the CobB CobQ family	ACIAD0540	pta	phosphate acetyltransferase	COG0280, COG0857	AAA_26, DRTGG, PTA_PTB	K13788
3NM7B	Aldehyde dehydrogenase family	ACIAD0546		putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	COG1012	Aldedh	K00131
3NKZH	Tryptophan halogenase	ACIAD0578		putative oxidoreductase protein; putative dehydrogenase (flavoprotein)		Trp_halogenase
3NJY5	Glycerophosphoryl diester phosphodiesterase family	ACIAD0632		putative glycerophosphodiester phosphodiesterase	COG0584	GDPD	K01126
3NK91	NADH:flavin oxidoreductase / NADH oxidase family	ACIAD0709		putative FMN oxidoreductase		Oxidored_FMN
3NJ47	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0730	nuoA	NADH dehydrogenase I chain A	COG0838	Oxidored_q4	K00330
3NIIG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0731	nuoB	NADH dehydrogenase I chain B	COG0377	Oxidored_q6	K00331
3NKS1	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0733	nuoCD	NADH dehydrogenase I chain C,D	COG0649, COG0852	Complex1_30kDa, Complex1_49kDa	K13378
3NK9H	Thioredoxin-like [2Fe-2S] ferredoxin	ACIAD0734	nuoE	NADH dehydrogenase I chain E	COG1905	2Fe-2S_thioredx	K00334
3NK5F	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	ACIAD0735	nuoF	NADH dehydrogenase I chain F	COG1894	Complex1_51K, NADH_4Fe-4S, SLBB	K00335
3NJ2B	COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)	ACIAD0736	nuoG	NADH dehydrogenase I chain G	COG1034	Fer2_4, Molybdop_Fe4S4, Molybdopterin, NADH-G_4Fe-4S_3	K00336
3NJI6	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	ACIAD0737	nuoH	NADH dehydrogenase I chain H	COG1005	NADHdh	K00337
3NIV2	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0738	nuoI	NADH dehydrogenase I chain I, 2Fe-2S ferredoxin-related	COG1143	Fer4	K00338
3NM35	Belongs to the complex I subunit 6 family	ACIAD0739	nuoJ	NADH dehydrogenase I chain J	COG0839	Oxidored_q3	K00339
3NNIR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0740	nuoK	NADH-quinone oxidoreductase chain K (NADH dehydrogenase I, chain K) (NDH-1, chain K) (NUO11)	COG0713	Oxidored_q2	K00340
3NKWW	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	ACIAD0741	nuoL	NADH dehydrogenase I chain L	COG1009	Proton_antipo_M, Proton_antipo_N	K00341
3NK34	COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)	ACIAD0742	nuoM	NADH dehydrogenase I chain M, membrane subunit	COG1008	Proton_antipo_M	K00342
3NKCK	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ACIAD0743	nuoN	NADH dehydrogenase I chain N	COG1007	Proton_antipo_M	K00343
3NJVN	Oxidoreductase NAD-binding domain	ACIAD0747	fpr	ferredoxin--NADP+ reductase	COG1018	FAD_binding_6, NAD_binding_1	K00528
3NKM0	Belongs to the iron ascorbate-dependent oxidoreductase family	ACIAD0764		putative oxidoreductase		2OG-FeII_Oxy, DIOX_N
3NM2K	Nitroreductase family	ACIAD0803		putative nitroreductase		Nitroreductase
3NIRK	EcsC protein family	ACIAD0880		conserved hypothetical protein		EcsC
3NJMY	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	ACIAD0890	trxB	thioredoxin reductase 1	COG0492	Pyr_redox_2	K00384
3NK7E	Aldehyde dehydrogenase family	ACIAD0960		putative succinate-semialdehyde dehydrogenase [NADP+] (GabD-like)	COG1012	Aldedh	K00135
3NSQD	non-haem dioxygenase in morphine synthesis N-terminal	ACIAD0977		putative dioxygenase		2OG-FeII_Oxy, DIOX_N
3NJUK	2Fe-2S iron-sulfur cluster binding domain	ACIAD0979	vanB	vanillate O-demethylase oxidoreductase (Vanillate degradation ferredoxin-like protein)	COG1018	Fer2, NAD_binding_1	K03863
3NNDK	FAD binding domain	ACIAD0984		putative hydroxylase involved in salicylate metabolism (SalA-like)	COG0654	FAD_binding_3, NAD_binding_8	K00480
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD0998		putative aldehyde dehydrogenase		Aldedh
3NJ1C	Malate:quinone oxidoreductase (Mqo)	ACIAD1007	mqo	malate dehydrogenase, FAD/NAD(P)-binding domain	COG0579	Mqo	K00116
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD1009	betB	NAD+-dependent betaine aldehyde dehydrogenase	COG1012	Aldedh	K00130
3NJJY	Dehydrogenase E1 component	ACIAD1017	acoA	Acetoin dehydrogenase E1 component alpha-subunit	COG1071	E1_dh	K21416
3NKUU	Transketolase, C-terminal domain	ACIAD1018	acoB	Acetoin dehydrogenase E1 component beta-subunit	COG0022	Transket_pyr, Transketolase_C	K21417
3NKCE	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	ACIAD1019	acoC	dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex	COG0508	2-oxoacid_dh, Biotin_lipoyl, E3_binding	K00627
3NMC8	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	ACIAD1020	acoD	Dihydrolipoyl dehydrogenase (E3 component of acetoin cleaving system) (Dihydrolipoamide dehydrogenase)	COG1249	Pyr_redox_2, Pyr_redox_dim	K00382
3NK16	Alcohol dehydrogenase GroES-like domain	ACIAD1021		putative acetoin reductase/2,3-butanediol dehydrogenase (bdhA)	COG1063	ADH_N, ADH_zinc_N	K00004
3NJ8Q	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins	ACIAD1052		putative factor of maturation of Fe/S proteins (NfuA)	COG0316, COG0694	Fe-S_biosyn, NifU	K07400
3NK5H	Pyridine nucleotide-disulphide oxidoreductase	ACIAD1065	rubB	rubredoxin-NAD(+) reductase	COG1251	Pyr_redox_2	K05297
3NT25	Rubredoxin	ACIAD1066	rubA	rubredoxin		Rubredoxin
3NIV0	Citrate transporter	ACIAD1074	citN	citrate transporter	COG2851	CitMHS	K03300
3NJIH	Isocitrate lyase	ACIAD1084	aceA	isocitrate lyase	COG2224	ICL	K01637
3NJVT	Part of a membrane complex involved in electron transport	ACIAD1109		conserved hypothetical protein; putative iron-sulfur protein	COG2878	FeS, Fer4_21	K03616
3NK3B	FAD binding domain	ACIAD1127	ubiH	ubiH protein, 2-octaprenyl-6-methoxyphynol hydroxylase, FAD/NAD(P)-binding	COG0654	FAD_binding_3	K03185
3NIR6	Squalene epoxidase	ACIAD1128	ubiF	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase		FAD_binding_3
3NIRV	NADH:flavin oxidoreductase / NADH oxidase family	ACIAD1143		putative FMN oxidoreductase		Oxidored_FMN
3NIEV	2,4-dienoyl-coA reductase	ACIAD1155	fadH	2,4-dienoyl-CoA reductase [NADPH] (2,4-dienoyl coenzyme A reductase)	COG0446, COG1902	Oxidored_FMN, Pyr_redox_2	K00219
3NKCF	Isocitrate dehydrogenase	ACIAD1187	idh	isocitrate dehydrogenase	COG0538	IDH	K00031
3NKE6	Isocitrate/isopropylmalate dehydrogenase	ACIAD1190	icd	isocitrate dehydrogenase	COG0538	Iso_dh	K00031
3NJRK	Ferric reductase NAD binding domain	ACIAD1207		putative oxidoreductase		FAD_binding_6, Fer2, NAD_binding_1
3NNJH	Belongs to the glutaredoxin family. Monothiol subfamily	ACIAD1232		putative glutaredoxin-like protein (grxD-like)	COG0278	Glutaredoxin	K07390
3NJBW	Alkyl hydroperoxide reductase	ACIAD1234	ahpF	alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides	COG3634	Pyr_redox_2, Thioredoxin_3	K03387
3NIEN	Prokaryotic cytochrome b561	ACIAD1246		putative cytochrome	COG3038	Ni_hydr_CYTB	K12262
3NIX3	Aldo/keto reductase family	ACIAD1261		putative oxidoreductase, aldo/keto reductase family		Aldo_ket_red
3NISM	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate	ACIAD1287	aruD	succinylglutamic semialdehyde dehydrogenase	COG1012	Aldedh	K06447
3NKM0	Belongs to the iron ascorbate-dependent oxidoreductase family	ACIAD1296		putative oxidoreductase		2OG-FeII_Oxy, DIOX_N
3NM6Z	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ACIAD1301		putative glycerate dehydrogenase	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00018
3NJP3	Nitroreductase family	ACIAD1316		putative nitroreductase		Nitroreductase
3NJWE	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ACIAD1327	tkrA	Glyoxylate reductase / Glyoxylatereductase / Hydroxypyruvate reductase , 2-ketoaldonate reductase, broad specificity	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00090
3NNH5	Ferredoxin, 2Fe-2S type, ISC system	ACIAD1398	fdx	[2FE-2S] ferredoxin, electron carrer protein, believed to be involved in assembly of Fe-S clusters	COG0633	Fer2	K04755
3NNI0	Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system	ACIAD1402	iscA	iron-binding protein , believed to be involved in Fe-S protein formation or repair	COG0316	Fe-S_biosyn	K13628
3NN35	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	ACIAD1403	iscU	iron-binding protein believed to be involved in Fe-S protein formation or repair; function as a scaffold for the assembly of the transiently bound Fe/S cluster	COG0822	NifU_N	K04488
3NKZF	FAD binding domain	ACIAD1424	salA	salicylate 1-monooxygenase	COG0654	FAD_binding_3	K00480
3NM15	Alcohol dehydrogenase GroES-like domain	ACIAD1429	areB	aryl-alcohol dehydrogenase		ADH_N, ADH_zinc_N	K00055
3NIKA	belongs to the aldehyde dehydrogenase family	ACIAD1430	areC	benzaldehyde dehydrogenase II	COG1012	Aldedh	K00141
3NIM5	Oxidoreductase FAD-binding domain	ACIAD1438	benC	benzoate 1,2-dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase]	COG0633, COG1018	FAD_binding_6, Fer2, NAD_binding_1	K05784
3NIRI	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	ACIAD1454		putative Zn-dependent oxidoreductase	COG0604	ADH_N, ADH_zinc_N_2	K00344
3NNIM	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ACIAD1498	fdxA	7-Fe ferredoxin	COG1146	DUF3470, Fer4	K05524
3NJ1I	Luciferase-like monooxygenase	ACIAD1505		putative Dibenzothiophene desulfurization enzyme	COG2141	Bac_luciferase	K04091
3NMJA	Luciferase-like monooxygenase	ACIAD1518		putative alkanesulfonate monooxygenase	COG2141	Bac_luciferase	K04091
3NM57	Luciferase-like monooxygenase	ACIAD1527		putative FMNH2-dependent methane/alkanesulfonate monooxygenase	COG2141	Bac_luciferase	K04091
3NM0C	Luciferase-like monooxygenase	ACIAD1535		putative FMNH2-dependent monooxygenase (sulfonate).	COG2141	Bac_luciferase	K04091
3NJME	TIGRFAM CitB domain protein	ACIAD1536	TcuC	Fe-S oxidoreductase			K13795
3NJDW	FAD dependent oxidoreductase	ACIAD1537	TcuA	tricarballylate dehydrogenase	COG1053	FAD_binding_2	K13796
1R58D	signal Peptide	ACIAD1574		hypothetical protein		Phenol_MetA_deg
1SYNI	cytochrome p450	ACIAD1575	linC	linalool 8-monooxygenase (Cytochrome P450 111) (Cytochrome P450lin)	COG2124	p450	K05525
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD1577		putative aldehyde dehydrogenase	COG1012	Aldedh	K00128
3NM15	Alcohol dehydrogenase GroES-like domain	ACIAD1578		putative aryl-alcohol dehydrogenase (Benzyl alcohol dehydrogenase) (XylB-like)		ADH_N, ADH_zinc_N	K00055
COG0633	Ferredoxin	ACIAD1579		putative ferredoxin (electron transport iron-sulfur protein)	COG0633	Fer2	K04755
COG0633	Ferredoxin	ACIAD1579		putative ferredoxin (electron transport iron-sulfur protein)	COG0633	Fer2	K04755
3NTJP	Reductase C-terminal	ACIAD1580		putative ferredoxin reductase component (dioxygenase)	COG0446	Pyr_redox_2, Reductase_C	K00529
3NKW5	Luciferase-like monooxygenase	ACIAD1595	ntaA	nitrilotriacetate monooxygenase component A (NTA monooxygenase component A) (NTA-MO A)		Bac_luciferase
3NKPT	Aldo/keto reductase family	ACIAD1596		putative oxidoreductase	COG0667	Aldo_ket_red	K19265
3NMNU	Taurine catabolism dioxygenase TauD, TfdA family	ACIAD1600		putative alkylsulfatase (AtsK)	COG2175	TauD	K22303
3NIFA	Aldehyde dehydrogenase family	ACIAD1604	mmsA	methylmalonate-semialdehyde dehydrogenase, oxidoreductase protein	COG1012	Aldedh	K00140
3NM9G	Putative MetA-pathway of phenol degradation	ACIAD1619		conserved hypothetical protein		Phenol_MetA_deg
3NJKD	Oxidizes proline to glutamate for use as a carbon and nitrogen source	ACIAD1646	putA	bifunctional protein [Includes: proline dehydrogenase (Proline oxidase); delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase)]	COG1012, COG0506, COG4230	Aldedh, Pro_dh, Pro_dh-DNA_bdg	K13821
3NIEV	2,4-dienoyl-coA reductase	ACIAD1654	fadH	2,4-dienoyl-CoA reductase	COG0446, COG1902	Oxidored_FMN, Pyr_redox_2	K00219
3NK8K	Electron transfer flavoprotein-ubiquinone oxidoreductase	ACIAD1680	etfD	electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring-flavoprotein dehydrogenase)	COG0644	ETF_QO, FAD_binding_2	K00311
3NJFH	CoA-transferase family III	ACIAD1683	caiB	L-carnitine dehydrogenase		CoA_transf_3
3NJFH	CoA-transferase family III	ACIAD1687	caiB	L-carnitine dehydrogenase		CoA_transf_3
3NM5W	Acyl-CoA dehydrogenase, C-terminal domain	ACIAD1693	acads4	Acyl-CoA dehydrogenase, short-chain specific	COG1960	Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N	K06446
3NJH0	Acyl-CoA dehydrogenase N terminal	ACIAD1700	acdB	acyl-CoA dehydrogenase		Acyl-CoA_dh_1, Acyl-CoA_dh_C, Acyl-CoA_dh_M, Acyl-CoA_dh_N, AcylCoA_DH_N
3NJZH	FAD binding domain	ACIAD1719	pobA	p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3- monooxygenase)	COG0654	FAD_binding_3	K00481
3NJFQ	Acyl-CoA dehydrogenase, C-terminal domain	ACIAD1723	hcaD	acyl coenzyme A dehydrogenase		Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N	K00255
3NIKA	belongs to the aldehyde dehydrogenase family	ACIAD1725	hcaB	hydroxybenzaldehyde dehydrogenase	COG1012	Aldedh	K21802
3NJAB	Zinc-binding dehydrogenase	ACIAD1743		putative oxydoreductase protein, zinc-containing (quinone oxidoreductase, NADPH dependent)		ADH_N, ADH_zinc_N
3NKBY	Cytochrome bd terminal oxidase subunit II	ACIAD1749	cioB	ubiquinol oxidase subunit II, cyanide insensitive	COG1294	Cyt_bd_oxida_II	K00426
3NJ8Y	Ubiquinol Oxidase	ACIAD1750	cioA	ubiquinol oxidase subunit I, cyanide insensitive	COG1271	Cyt_bd_oxida_I	K00425
3NPJG	Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism	ACIAD1755	mdcC	malonate decarboxylase, delta subunit		ACP	K13931
3NK2I	FAD binding domain	ACIAD1808		putative monooxygenase		FAD_binding_3
3NTJF	Putative MetA-pathway of phenol degradation	ACIAD1813		conserved hypothetical protein; putative signal peptide		Phenol_MetA_deg
3NMAR	Putative MetA-pathway of phenol degradation	ACIAD1814		conserved hypothetical protein; putative signal peptide		Phenol_MetA_deg
3NQZ7	Acyl-CoA dehydrogenase, middle domain	ACIAD1821		putative acyl-CoA dehydrogenase		Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N
1RPXX	Acyl-CoA synthetase (NDP forming)	ACIAD1826	pauA	pimeloyl-CoA synthetase		ATP-grasp_5, CoA_binding_2, Succ_CoA_lig
3NK6K	Luciferase-like monooxygenase	ACIAD1830		putative monooxygenase		Bac_luciferase
3NSWS	NADH:flavin oxidoreductase / NADH oxidase family	ACIAD1836		putative oxidoreductase (NADH-dependent flavin oxidoreductase)		Oxidored_FMN
3NIU1	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	ACIAD1879	frmA	Alcohol dehydrogenase class 3 (Alcohol dehydrogenase class III) (S-(hydroxymethyl)glutathione dehydrogenase) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH)	COG1062	ADH_N, ADH_zinc_N	K00121
3NJE0	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	ACIAD1890	fumC	fumarase C (fumarate hydratase Class II)	COG0114	FumaraseC_C, Lyase_1	K01679
3NJ0R	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	ACIAD1908	nasA	nitrate reductase, large subunit	COG0243	Fer2_BFD, Molybdop_Fe4S4, Molybdopterin, Molydop_binding	K00372
3NK2Y	Rieske-like [2Fe-2S] domain	ACIAD1909		putative nitrate reductase (electron transfer subunit) AND putative nitrite reductase (small subunit)		Pyr_redox_2, Rieske_2
3NK8P	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	ACIAD1910	nasD	nitrite reductase, large subunit, nucleotide- and Fe/S-cluster binding	COG1251	Fer2_BFD, NIR_SIR, NIR_SIR_ferr, Pyr_redox_2	K00362
3NKKU	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	ACIAD1915		putative molybdopterin oxidoreductase, alpha subunit (fdhA)		Molybdopterin, Molydop_binding
3NJ6X	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	ACIAD1916	fdhD	formate dehydrogenase formation protein	COG1526	FdhD-NarQ	K02379
3NIWS	nitroreductase	ACIAD1923	nfnB	oxygen-insensitive NADPH nitroreductase	COG0778	Nitroreductase	K10679
3NJIG	Citrate transporter	ACIAD1931		putative magnesium citrate secondary transporter	COG2851	CitMHS	K03300
3NM9G	Putative MetA-pathway of phenol degradation	ACIAD1936		conserved hypothetical protein; putative signal peptide		Phenol_MetA_deg
3NJ3I	Iron-containing alcohol dehydrogenase	ACIAD1950		putative iron-containing alcohol dehydrogenase	COG0604, COG1064, COG1062, COG1454	Fe-ADH	K00001
3NIGY	alcohol dehydrogenase	ACIAD2015		putative alcohol dehydrogenase	COG1454	Fe-ADH	K13954
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD2018	acoD	Acetaldehyde dehydrogenase 2 (Acetaldehyde dehydrogenase II) (ACDH-II)	COG1012	Aldedh	K00138
3NJ0V	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	ACIAD2043		conserved hypothetical protein; putative ferredoxin	COG1600	DUF1730, Fer4_16	K18979
3NISQ	Luciferase-like monooxygenase	ACIAD2066		putative monooxygenase (DszA-like)		Bac_luciferase
3NJJ1	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	ACIAD2098	QueH	Epoxyqueuosine reductase QueH	COG1636	DUF208	K09765
3NJDI	4Fe-4S single cluster domain	ACIAD2207		putative aminomutase (kamA-like)	COG1509	Fer4_14	K19810
3NIFK	Oxidoreductase FAD-binding domain	ACIAD2244	fpr	ferredoxin--NADP+ reductase	COG1018	FAD_binding_6, NAD_binding_1	K00528
3NJBW	Alkyl hydroperoxide reductase	ACIAD2250	ahpF	alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides	COG3634	Pyr_redox_2, Thioredoxin_3	K03387
3NJHT	Soluble pyridine nucleotide transhydrogenase	ACIAD2274	sthA	soluble pyridine nucleotide transhydrogenase (NAD(P)(+) transhydrogenase [B-specific])	COG1249	Pyr_redox_2, Pyr_redox_dim	K00322
3NJCT	Malic enzyme, NAD binding domain	ACIAD2287	maeB	NAD(P)-dependent malic enzyme ; bifunctional: NADP-dependent malic oxidoreductase (N-terminal); phosphotransacetylase (C-terminal)]	COG0280, COG0281	Malic_M, PTA_PTB, malic	K00029
3NK2C	oxidase, subunit	ACIAD2290	cydA	cytochrome d terminal oxidase, polypeptide subunit I	COG1271	Cyt_bd_oxida_I	K00425
3NJ1G	oxidase, subunit	ACIAD2291	cydB	cytochrome d terminal oxidase polypeptide subunit II	COG1294	Cyt_bd_oxida_II	K00426
3NJXI	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	ACIAD2335	glcB	malate synthase G	COG2225	Malate_synthase	K01638
3NR1D	non-haem dioxygenase in morphine synthesis N-terminal	ACIAD2388		putative oxidoreductase		2OG-FeII_Oxy
3NM2Z	Belongs to the aconitase IPM isomerase family	ACIAD2395	acnB	aconitate hydratase 2	COG1049	Aconitase, Aconitase_2_N, Aconitase_B_N	K01682
3NSGJ	Heavy-metal-associated domain	ACIAD2401	copZ	copper insertion chaperone and transporter component	COG2608	HMA	K07213
3NKWP	Luciferase-like monooxygenase	ACIAD2420		putative monooxygenase		Bac_luciferase
3NK4D	COX Aromatic Rich Motif	ACIAD2425	cyoA	cytochrome o ubiquinol oxidase subunit II	COG1622	COX2, COX_ARM	K02297
3NJ4I	Belongs to the heme-copper respiratory oxidase family	ACIAD2426	cyoB	cytochrome o ubiquinol oxidase subunit I	COG0843	COX1	K02298
3NIPT	Cytochrome c oxidase subunit III	ACIAD2427	cyoC	cytochrome o ubiquinol oxidase subunit III	COG1845	COX3	K02299
3NNHS	Prokaryotic Cytochrome C oxidase subunit IV	ACIAD2428	cyoD	cytochrome o ubiquinol oxidase subunit IV	COG3125	COX4_pro	K02300
3NKXD	GXGXG motif	ACIAD2526	mgsB	putative N-methyl glutamate synthase subunit B		GXGXG	K22082
3NKKD	Luciferase-like monooxygenase	ACIAD2536		putative coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase		Bac_luciferase
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD2539	tgnE	succinate-semialdehyde dehydrogenase	COG1012	Aldedh	K00135
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD2542	tgnC	MFMB ((Z)-2-((N-methylformamido)methylene)-5-hydroxy-butyrolactone) dehydrogenase	COG1012	Aldedh	K00128
3NK6K	Luciferase-like monooxygenase	ACIAD2543	tgnB	trigonelline monooxygenase, , oxygenase component		Bac_luciferase
3NJZ4	Nitroreductase family	ACIAD2608		putative nitrorecductase		Nitroreductase
3NIEY	Electron transfer flavoprotein	ACIAD2654	etfA	electron transfer flavoprotein alpha-subunit	COG2025	ETF, ETF_alpha	K03522
3NIQV	Electron transfer flavoprotein	ACIAD2655	etfB	electron transfer flavoprotein beta-subunit	COG2086	ETF	K03521
3NK3C	Oxidoreductase FAD-binding domain	ACIAD2671	antC	anthranilate dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase ]	COG0543	FAD_binding_6, Fer2, NAD_binding_1	K11311
3NJSU	Putative MetA-pathway of phenol degradation	ACIAD2673		conserved hypothetical protein; putative signal peptide		Phenol_MetA_deg
3NMD9	oxidoreductase	ACIAD2675	smoA	styrene monooxygenase
3NKZF	FAD binding domain	ACIAD2721		conserved hypothetical protein; putative hydrolase/monooxygenase		FAD_binding_3
3NKMZ	NADH:flavin oxidoreductase / NADH oxidase family	ACIAD2725		putative oxidoreductase, NADH-dependent flavin oxidoreductase		Oxidored_FMN
3NT08	Zinc-binding dehydrogenase	ACIAD2738		putative NADPH:quinone reductase and related Zn-dependent oxidoreductase	COG0604	ADH_N, ADH_zinc_N	K00344
3NK4I	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	ACIAD2755		putative methyl-cis-aconitic acid hydratase (AcnM)	COG1048	Aconitase, Aconitase_C	K20455
3NKGX	Belongs to the citrate synthase family	ACIAD2756	prpC	methylcitrate synthase (citrate synthase 2)	COG0372	Citrate_synt	K01659
3NMSD	Citrate transporter	ACIAD2818	citN	citrate transporter	COG2851	CitMHS	K03300
3NK4S	CoA-transferase family III	ACIAD2821		putative CoA transferase		CoA_transf_3
3NJM2	C-terminal domain of alpha-glycerophosphate oxidase	ACIAD2844	glpD	glycerol-3-phosphate dehydrogenase	COG0578	DAO, DAO_C	K00111
3NKDR	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	ACIAD2872	sucD	succinyl-CoA synthetase alpha chain	COG0074	CoA_binding, Ligase_CoA	K01902
3NIRD	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	ACIAD2874	lpd	dihydrolipoamide dehydrogenase E3 subunit of 2-oxoglutarate dehydrogenase complex (Glycine oxidation system L-factor)	COG1249	Pyr_redox_2, Pyr_redox_dim	K00382
3NIMS	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	ACIAD2875	sucB	dihydrolipoamide succinyltransferase, E2 component of 2-oxoglutarate dehydrogenase complex	COG0508	2-oxoacid_dh, Biotin_lipoyl, E3_binding	K00658
3NIYG	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	ACIAD2876	sucA	2-oxoglutarate decarboxylase E1 component of the 2-oxoglutarate dehydrogenase complex	COG0567	2-oxogl_dehyd_N, E1_dh, OxoGdeHyase_C, Transket_pyr	K00164
3NIGB	succinate dehydrogenase	ACIAD2879	sdhB	succinate dehydrogenase, iron-sulfur subunit	COG0479	Fer2_3, Fer4_8	K00240
3NJNU	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	ACIAD2880	sdhA	succinate dehydrogenase, flavoprotein subunit	COG1053	FAD_binding_2, Succ_DH_flav_C	K00239
3NNHR	Succinate dehydrogenase hydrophobic membrane anchor subunit	ACIAD2881	sdhD	succinate dehydrogenase, hydrophobic subunit	COG2142	Sdh_cyt	K00242
3NNJ6	succinate dehydrogenase	ACIAD2882	sdhC	succinate dehydrogenase, cytochrome b556 subunit	COG2009	Sdh_cyt	K00241
3NKP2	Belongs to the citrate synthase family	ACIAD2886	gltA	citrate synthase	COG0372	Citrate_synt	K01647
3NPI1	Ferredoxin	ACIAD2892		putative ferredoxin [4Fe-4S] (Fdx)		Fer4
3NJYF	Iron-containing alcohol dehydrogenase	ACIAD2929		putative alcohol dehydrogenase	COG0604, COG1064, COG1062, COG1454	Fe-ADH	K00001
3NKEQ	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	ACIAD2982	cysI	Sulfite reductase (NADPH) hemoprotein beta-component	COG0155	NIR_SIR, NIR_SIR_ferr	K00381
3NJIN	CoA-transferase family III	ACIAD2985		putative acyl-CoA transferase		CoA_transf_3
3NJ3M	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	ACIAD3078	pntB	pyridine nucleotide transhydrogenase, beta subunit	COG1282	PNTB	K00325
3NNJ0	4TM region of pyridine nucleotide transhydrogenase, mitoch	ACIAD3079	pntA-2	pyridine nucleotide transhydrogenase (proton pump), alpha subunit (part2)	COG3288	PNTB_4TM	K00324
3NJZX	Alanine dehydrogenase/PNT, N-terminal domain	ACIAD3080	pntA-1	pyridine nucleotide transhydrogenase (proton pump), alpha subunit (part1)	COG3288	AlaDh_PNT_C, AlaDh_PNT_N	K00324
3NKPZ	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	ACIAD3090	acnA	aconitate hydratase 1	COG0065, COG1048	Aconitase, Aconitase_C	K01681
3NT27	Aldo/keto reductase family	ACIAD3128		putative oxidoreductase		Aldo_ket_red
3NK4N	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	ACIAD3145		putative dihydrolipoamide dehydrogenase E3 component of pyruvate/2-oxoglutarate dehydrogenase complex	COG1249	Pyr_redox_2, Pyr_redox_dim	K00382
3NIHG	Catalyzes the reversible oxidation of malate to oxaloacetate	ACIAD3155	mdh	malate dehydrogenase	COG0039	Ldh_1_C, Ldh_1_N	K00024
3NT86	Globin	ACIAD3226		putative flavohemoprotein		Globin
3NK8K	Electron transfer flavoprotein-ubiquinone oxidoreductase	ACIAD3259	etfD	electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring-flavoprotein dehydrogenase)	COG0644	ETF_QO, FAD_binding_2	K00311
3NJ61	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ACIAD3278	hprA	glycerate dehydrogenase	COG1052	2-Hacid_dh, 2-Hacid_dh_C	K00018
3NJUR	FAD linked oxidases, C-terminal domain	ACIAD3300		putative FAD/FMN-containing dehydrogenase		FAD-oxidase_C, FAD_binding_4
3NKH8	Thiamine pyrophosphate enzyme, central domain	ACIAD3381	poxB	pyruvate dehydrogenase (quinone)	COG0028	TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N	K00156
3NMFK	acetyl-CoA hydrolase	ACIAD3390		putative acetyl-CoA hydrolase/transferase	COG0427	AcetylCoA_hyd_C, AcetylCoA_hydro	K18118
3NIN2	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	ACIAD3445	gabD	NADP+ -dependent succinate semialdehyde dehydrogenase	COG1012	Aldedh	K00135
3NJK1	Luciferase-like monooxygenase	ACIAD3471		putative sulfonate monooxygenase (MsuD)	COG2141	Bac_luciferase	K17228
3NKMZ	NADH:flavin oxidoreductase / NADH oxidase family	ACIAD3496	xenB	xenobiotic reductase		Oxidored_FMN
3NJS0	acetyltransferase component of pyruvate dehydrogenase complex	ACIAD3506	aceF	dihydrolipoamide S-acetyltransferase, E2 component of the pyruvate dehydrogenase complex	COG0508	2-oxoacid_dh, Biotin_lipoyl, E3_binding	K00627
3NKA2	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	ACIAD3507	aceE	pyruvate decarboxylase, E1 component of the pyruvate dehydrogenase complex.	COG2609	Transketolase_N	K00163
3NJXZ	Thiol disulfide interchange protein	ACIAD3532	dsbD	thiol:disulfide interchange protein precursor	COG0526	DsbC, DsbD, Thioredoxin	K04084
3NK2I	FAD binding domain	ACIAD3540	hpxO	FAD-dependent urate oxidase		FAD_binding_3	K16839
3NSYJ	Pyridine nucleotide-disulphide oxidoreductase	ACIAD3633	ndh	NADH dehydrogenase II	COG1252	Pyr_redox_2	K03885
3NMG4	Belongs to the aldehyde dehydrogenase family	ACIAD3642		putative aldehyde dehydrogenase		Aldedh

Iron-sulfur cluster insertion protein ErpA

putative chaperone involved in Fe-S cluster assembly and activation (HesB-like)

Fe-S_biosyn

Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate

ACIAD0027

rutA

Putative Pyrimidine monooxygenase rutA (Pyrimidine utilization protein A)

COG2141

Bac_luciferase

K09018

3NNA1

Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway

ACIAD0030

rutF

putative FMN reductase (NADH) RutF (Pyrimidine utilization protein F)

COG1853

Flavin_Reduct

K09024

3NITN

Catalyzes the desulfonation of aliphatic sulfonates

ACIAD0036

ssuD

FMNH(2)-dependent alkanesulfonate monooxygenase

COG2141

Bac_luciferase

K04091

3NK4F

Oxidoreductase NAD-binding domain

ACIAD0048

putative oxidoreductase

FAD_binding_6, Fer2, NAD_binding_1

3NJK8

L-lactate permease

ACIAD0106

lldP

L-lactate permease

COG1620

Lactate_perm

K00427

3NJCA

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain

ACIAD0108

lldD

L-lactate dehydrogenase, FMN linked

COG1304

FMN_dh

K00101

3NIS1

Catalyzes the oxidation of D-lactate to pyruvate

ACIAD0109

dld

D-lactate dehydrogenase, NADH independent, FAD-binding domain

COG0277

FAD_binding_4, Lact-deh-memb

K03777

3NITY

Oxidative deamination of D-amino acids

ACIAD0115

dadA

D-amino acid dehydrogenase, small subunit

COG0665

DAO

K00285

3NM93

Aldehyde dehydrogenase family

ACIAD0131

2-ketoglutarate semialdehyde dehydrogenase

Aldedh

K13877

3NM6Z

Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology

ACIAD0133

putative 2-hydroxyacid dehydrogenase

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00018

3NIZP

malate dehydrogenase (decarboxylating) (NAD+) activity

ACIAD0166

sfcA

NAD-linked malate dehydrogenase, Rossman fold

Malic_M, malic

ATP synthase I chain

atpI

ATP synthase protein I

COG3312

ATP-synt_I

K02116

3NJCY

it plays a direct role in the translocation of protons across the membrane

ACIAD0180

atpB

membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly

COG0356

ATP-synt_A

K02108

3NPA2

F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation

ACIAD0182

atpE

membrane-bound ATP synthase, F0 sector, subunit c

ATP-synt_C

3NJBM

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)

ACIAD0183

atpF

membrane-bound ATP synthase, F0 sector, subunit b

COG0711

ATP-synt_B

K02109

3NIHZ

F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation

ACIAD0184

atpH

membrane-bound ATP synthase , F1 sector, delta-subunit

COG0712

OSCP

K02113

3NJ2E

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

ACIAD0185

atpA

membrane-bound ATP synthase , F1 sector, alpha-subunit

COG0056

ATP-synt_ab, ATP-synt_ab_C, ATP-synt_ab_N

K02111

3NJVA

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

ACIAD0186

atpG

membrane-bound ATP synthase , F1 sector, gamma-subunit

COG0224

ATP-synt

K02115

3NK1R

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

ACIAD0187

atpD

membrane-bound ATP synthase , F1 sector, beta-subunit

COG0055

ATP-synt_ab, ATP-synt_ab_N

K02112

3NN50

Produces ATP from ADP in the presence of a proton gradient across the membrane

ACIAD0188

atpC

membrane-bound ATP synthase , F1 sector, epsilon-subunit

ATP-synt_DE_N

UPF0313 protein

putative UPF0313 SAM protein

DUF3362, Radical_SAM, Radical_SAM_N

3NJX9

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions

ACIAD0239

ppa

inorganic pyrophosphatase

COG0221

Pyrophosphatase

K01507

3NP04

Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes

ACIAD0282

Putative Fe(2+)-trafficking protein (yggX-like)

Iron_traffic

3NIJN

Proton-conducting membrane transporter

ACIAD0374

phaD

pH adaptation potassium efflux system D transmembrane protein

COG0651

Proton_antipo_M

K05561

3NIM9

Domain related to MnhB subunit of Na+/H+ antiporter

ACIAD0376

phaAB

pH adaptation potassium efflux system transmembrane protein

COG1009

DUF4040, MnhB, Proton_antipo_M, Proton_antipo_N

K05559

3NIMA

FAD binding domain

ACIAD0381

putative oxidoreductase; putative flavoprotein monooxygenase

FAD_binding_3

3NJBI

serves to protect cells from the toxic effects of hydrogen peroxide

ACIAD0451

katA

catalase (hydroperoxidase II)

COG0753

Catalase, Catalase-rel

K03781

3NK2W

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate

ACIAD0469

leuB

3-isopropylmalate dehydrogenase

COG0473

Iso_dh

K00052

3NJP9

belongs to the aldehyde dehydrogenase family

ACIAD0503

calB

coniferyl aldehyde dehydrogenase (CALDH)

COG1012

Aldedh

K00154

3NJSC

Catalyzes the reversible hydration of fumarate to (S)- malate

ACIAD0538

fumA

fumarate hydratase

COG1838, COG1951

Fumerase, Fumerase_C

K01676

3NJD4

belongs to the CobB CobQ family

ACIAD0540

pta

phosphate acetyltransferase

COG0280, COG0857

AAA_26, DRTGG, PTA_PTB

K13788

3NM7B

Aldehyde dehydrogenase family

ACIAD0546

putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase

COG1012

Aldedh

K00131

3NKZH

Tryptophan halogenase

ACIAD0578

putative oxidoreductase protein; putative dehydrogenase (flavoprotein)

Trp_halogenase

3NJY5

Glycerophosphoryl diester phosphodiesterase family

ACIAD0632

putative glycerophosphodiester phosphodiesterase

COG0584

GDPD

K01126

3NK91

NADH:flavin oxidoreductase / NADH oxidase family

ACIAD0709

putative FMN oxidoreductase

Oxidored_FMN

3NJ47

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0730

nuoA

NADH dehydrogenase I chain A

COG0838

Oxidored_q4

K00330

3NIIG

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0731

nuoB

NADH dehydrogenase I chain B

COG0377

Oxidored_q6

K00331

3NKS1

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0733

nuoCD

NADH dehydrogenase I chain C,D

COG0649, COG0852

Complex1_30kDa, Complex1_49kDa

K13378

3NK9H

Thioredoxin-like [2Fe-2S] ferredoxin

ACIAD0734

nuoE

NADH dehydrogenase I chain E

COG1905

2Fe-2S_thioredx

K00334

3NK5F

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain

ACIAD0735

nuoF

NADH dehydrogenase I chain F

COG1894

Complex1_51K, NADH_4Fe-4S, SLBB

K00335

3NJ2B

COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)

ACIAD0736

nuoG

NADH dehydrogenase I chain G

COG1034

Fer2_4, Molybdop_Fe4S4, Molybdopterin, NADH-G_4Fe-4S_3

K00336

3NJI6

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone

ACIAD0737

nuoH

NADH dehydrogenase I chain H

COG1005

NADHdh

K00337

3NIV2

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0738

nuoI

NADH dehydrogenase I chain I, 2Fe-2S ferredoxin-related

COG1143

Fer4

K00338

3NM35

Belongs to the complex I subunit 6 family

ACIAD0739

nuoJ

NADH dehydrogenase I chain J

COG0839

Oxidored_q3

K00339

3NNIR

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0740

nuoK

NADH-quinone oxidoreductase chain K (NADH dehydrogenase I, chain K) (NDH-1, chain K) (NUO11)

COG0713

Oxidored_q2

K00340

3NKWW

COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit

ACIAD0741

nuoL

NADH dehydrogenase I chain L

COG1009

Proton_antipo_M, Proton_antipo_N

K00341

3NK34

COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)

ACIAD0742

nuoM

NADH dehydrogenase I chain M, membrane subunit

COG1008

Proton_antipo_M

K00342

3NKCK

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

ACIAD0743

nuoN

NADH dehydrogenase I chain N

COG1007

Proton_antipo_M

K00343

3NJVN

Oxidoreductase NAD-binding domain

ACIAD0747

fpr

ferredoxin--NADP+ reductase

COG1018

FAD_binding_6, NAD_binding_1

K00528

3NKM0

Belongs to the iron ascorbate-dependent oxidoreductase family

ACIAD0764

putative oxidoreductase

2OG-FeII_Oxy, DIOX_N

3NM2K

Nitroreductase family

ACIAD0803

putative nitroreductase

Nitroreductase

3NIRK

EcsC protein family

ACIAD0880

conserved hypothetical protein

EcsC

3NJMY

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family

ACIAD0890

trxB

thioredoxin reductase 1

COG0492

Pyr_redox_2

K00384

3NK7E

Aldehyde dehydrogenase family

ACIAD0960

putative succinate-semialdehyde dehydrogenase [NADP+] (GabD-like)

COG1012

Aldedh

K00135

3NSQD

non-haem dioxygenase in morphine synthesis N-terminal

ACIAD0977

putative dioxygenase

2OG-FeII_Oxy, DIOX_N

3NJUK

2Fe-2S iron-sulfur cluster binding domain

ACIAD0979

vanB

vanillate O-demethylase oxidoreductase (Vanillate degradation ferredoxin-like protein)

Fer2, NAD_binding_1

FAD binding domain

putative hydroxylase involved in salicylate metabolism (SalA-like)

COG0654

FAD_binding_3, NAD_binding_8

K00480

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD0998

putative aldehyde dehydrogenase

Aldedh

3NJ1C

Malate:quinone oxidoreductase (Mqo)

ACIAD1007

mqo

malate dehydrogenase, FAD/NAD(P)-binding domain

COG0579

Mqo

K00116

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD1009

betB

NAD+-dependent betaine aldehyde dehydrogenase

COG1012

Aldedh

K00130

3NJJY

Dehydrogenase E1 component

ACIAD1017

acoA

Acetoin dehydrogenase E1 component alpha-subunit

COG1071

E1_dh

K21416

3NKUU

Transketolase, C-terminal domain

ACIAD1018

acoB

Acetoin dehydrogenase E1 component beta-subunit

COG0022

Transket_pyr, Transketolase_C

K21417

3NKCE

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

ACIAD1019

acoC

dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex

COG0508

2-oxoacid_dh, Biotin_lipoyl, E3_binding

K00627

3NMC8

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

ACIAD1020

acoD

Dihydrolipoyl dehydrogenase (E3 component of acetoin cleaving system) (Dihydrolipoamide dehydrogenase)

COG1249

Pyr_redox_2, Pyr_redox_dim

K00382

3NK16

Alcohol dehydrogenase GroES-like domain

ACIAD1021

putative acetoin reductase/2,3-butanediol dehydrogenase (bdhA)

COG1063

ADH_N, ADH_zinc_N

K00004

3NJ8Q

Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins

ACIAD1052

putative factor of maturation of Fe/S proteins (NfuA)

COG0316, COG0694

Fe-S_biosyn, NifU

K07400

3NK5H

Pyridine nucleotide-disulphide oxidoreductase

ACIAD1065

rubB

rubredoxin-NAD(+) reductase

Pyr_redox_2

Rubredoxin

rubA

rubredoxin

Rubredoxin

3NIV0

Citrate transporter

ACIAD1074

citN

citrate transporter

CitMHS

Isocitrate lyase

aceA

isocitrate lyase

COG2224

ICL

K01637

3NJVT

Part of a membrane complex involved in electron transport

ACIAD1109

conserved hypothetical protein; putative iron-sulfur protein

FeS, Fer4_21

FAD binding domain

ubiH

ubiH protein, 2-octaprenyl-6-methoxyphynol hydroxylase, FAD/NAD(P)-binding

FAD_binding_3

Squalene epoxidase

ubiF

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase

FAD_binding_3

3NIRV

NADH:flavin oxidoreductase / NADH oxidase family

ACIAD1143

putative FMN oxidoreductase

Oxidored_FMN

3NIEV

2,4-dienoyl-coA reductase

ACIAD1155

fadH

2,4-dienoyl-CoA reductase [NADPH] (2,4-dienoyl coenzyme A reductase)

COG0446, COG1902

Oxidored_FMN, Pyr_redox_2

K00219

3NKCF

Isocitrate dehydrogenase

ACIAD1187

idh

isocitrate dehydrogenase

COG0538

IDH

K00031

3NKE6

Isocitrate/isopropylmalate dehydrogenase

ACIAD1190

icd

isocitrate dehydrogenase

COG0538

Iso_dh

K00031

3NJRK

Ferric reductase NAD binding domain

ACIAD1207

putative oxidoreductase

FAD_binding_6, Fer2, NAD_binding_1

3NNJH

Belongs to the glutaredoxin family. Monothiol subfamily

ACIAD1232

putative glutaredoxin-like protein (grxD-like)

COG0278

Glutaredoxin

K07390

3NJBW

Alkyl hydroperoxide reductase

ACIAD1234

ahpF

alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides

COG3634

Pyr_redox_2, Thioredoxin_3

K03387

3NIEN

Prokaryotic cytochrome b561

putative cytochrome

Ni_hydr_CYTB

Aldo/keto reductase family

ACIAD1261

putative oxidoreductase, aldo/keto reductase family

Aldo_ket_red

3NISM

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate

ACIAD1287

aruD

succinylglutamic semialdehyde dehydrogenase

COG1012

Aldedh

K06447

3NKM0

Belongs to the iron ascorbate-dependent oxidoreductase family

ACIAD1296

putative oxidoreductase

2OG-FeII_Oxy, DIOX_N

3NM6Z

Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology

ACIAD1301

putative glycerate dehydrogenase

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00018

3NJP3

Nitroreductase family

ACIAD1316

putative nitroreductase

Nitroreductase

3NJWE

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

ACIAD1327

tkrA

Glyoxylate reductase / Glyoxylatereductase / Hydroxypyruvate reductase , 2-ketoaldonate reductase, broad specificity

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00090

3NNH5

Ferredoxin, 2Fe-2S type, ISC system

ACIAD1398

fdx

[2FE-2S] ferredoxin, electron carrer protein, believed to be involved in assembly of Fe-S clusters

COG0633

Fer2

K04755

3NNI0

Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system

ACIAD1402

iscA

iron-binding protein , believed to be involved in Fe-S protein formation or repair

COG0316

Fe-S_biosyn

K13628

3NN35

A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters

ACIAD1403

iscU

iron-binding protein believed to be involved in Fe-S protein formation or repair; function as a scaffold for the assembly of the transiently bound Fe/S cluster

NifU_N

FAD binding domain

salA

salicylate 1-monooxygenase

COG0654

FAD_binding_3

K00480

3NM15

Alcohol dehydrogenase GroES-like domain

ACIAD1429

areB

aryl-alcohol dehydrogenase

ADH_N, ADH_zinc_N

K00055

3NIKA

belongs to the aldehyde dehydrogenase family

ACIAD1430

areC

benzaldehyde dehydrogenase II

COG1012

Aldedh

K00141

3NIM5

Oxidoreductase FAD-binding domain

ACIAD1438

benC

benzoate 1,2-dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase]

COG0633, COG1018

FAD_binding_6, Fer2, NAD_binding_1

K05784

3NIRI

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily

ACIAD1454

putative Zn-dependent oxidoreductase

COG0604

ADH_N, ADH_zinc_N_2

K00344

3NNIM

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions

ACIAD1498

fdxA

7-Fe ferredoxin

COG1146

DUF3470, Fer4

K05524

3NJ1I

Luciferase-like monooxygenase

ACIAD1505

putative Dibenzothiophene desulfurization enzyme

COG2141

Bac_luciferase

K04091

3NMJA

Luciferase-like monooxygenase

ACIAD1518

putative alkanesulfonate monooxygenase

COG2141

Bac_luciferase

K04091

3NM57

Luciferase-like monooxygenase

ACIAD1527

putative FMNH2-dependent methane/alkanesulfonate monooxygenase

COG2141

Bac_luciferase

K04091

3NM0C

Luciferase-like monooxygenase

ACIAD1535

putative FMNH2-dependent monooxygenase (sulfonate).

COG2141

Bac_luciferase

K04091

3NJME

TIGRFAM CitB domain protein

ACIAD1536

TcuC

Fe-S oxidoreductase

K13795

3NJDW

FAD dependent oxidoreductase

ACIAD1537

TcuA

tricarballylate dehydrogenase

FAD_binding_2

signal Peptide

hypothetical protein

Phenol_MetA_deg

1SYNI

cytochrome p450

ACIAD1575

linC

linalool 8-monooxygenase (Cytochrome P450 111) (Cytochrome P450lin)

COG2124

p450

K05525

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD1577

putative aldehyde dehydrogenase

COG1012

Aldedh

K00128

3NM15

Alcohol dehydrogenase GroES-like domain

ACIAD1578

putative aryl-alcohol dehydrogenase (Benzyl alcohol dehydrogenase) (XylB-like)

ADH_N, ADH_zinc_N

K00055

COG0633

Ferredoxin

ACIAD1579

putative ferredoxin (electron transport iron-sulfur protein)

Fer2

Ferredoxin

putative ferredoxin (electron transport iron-sulfur protein)

Fer2

Reductase C-terminal

putative ferredoxin reductase component (dioxygenase)

COG0446

Pyr_redox_2, Reductase_C

K00529

3NKW5

Luciferase-like monooxygenase

ACIAD1595

ntaA

nitrilotriacetate monooxygenase component A (NTA monooxygenase component A) (NTA-MO A)

Bac_luciferase

3NKPT

Aldo/keto reductase family

ACIAD1596

putative oxidoreductase

COG0667

Aldo_ket_red

K19265

3NMNU

Taurine catabolism dioxygenase TauD, TfdA family

ACIAD1600

putative alkylsulfatase (AtsK)

COG2175

TauD

K22303

3NIFA

Aldehyde dehydrogenase family

ACIAD1604

mmsA

methylmalonate-semialdehyde dehydrogenase, oxidoreductase protein

COG1012

Aldedh

K00140

3NM9G

Putative MetA-pathway of phenol degradation

ACIAD1619

conserved hypothetical protein

Phenol_MetA_deg

3NJKD

Oxidizes proline to glutamate for use as a carbon and nitrogen source

ACIAD1646

putA

bifunctional protein [Includes: proline dehydrogenase (Proline oxidase); delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase)]

COG1012, COG0506, COG4230

Aldedh, Pro_dh, Pro_dh-DNA_bdg

K13821

3NIEV

2,4-dienoyl-coA reductase

ACIAD1654

fadH

2,4-dienoyl-CoA reductase

COG0446, COG1902

Oxidored_FMN, Pyr_redox_2

K00219

3NK8K

Electron transfer flavoprotein-ubiquinone oxidoreductase

ACIAD1680

etfD

electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring-flavoprotein dehydrogenase)

COG0644

ETF_QO, FAD_binding_2

K00311

3NJFH

CoA-transferase family III

ACIAD1683

caiB

L-carnitine dehydrogenase

CoA_transf_3

3NJFH

CoA-transferase family III

ACIAD1687

caiB

L-carnitine dehydrogenase

CoA_transf_3

3NM5W

Acyl-CoA dehydrogenase, C-terminal domain

ACIAD1693

acads4

Acyl-CoA dehydrogenase, short-chain specific

COG1960

Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N

K06446

3NJH0

Acyl-CoA dehydrogenase N terminal

ACIAD1700

acdB

acyl-CoA dehydrogenase

Acyl-CoA_dh_1, Acyl-CoA_dh_C, Acyl-CoA_dh_M, Acyl-CoA_dh_N, AcylCoA_DH_N

3NJZH

FAD binding domain

ACIAD1719

pobA

p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3- monooxygenase)

COG0654

FAD_binding_3

K00481

3NJFQ

Acyl-CoA dehydrogenase, C-terminal domain

ACIAD1723

hcaD

acyl coenzyme A dehydrogenase

Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N

K00255

3NIKA

belongs to the aldehyde dehydrogenase family

ACIAD1725

hcaB

hydroxybenzaldehyde dehydrogenase

COG1012

Aldedh

K21802

3NJAB

Zinc-binding dehydrogenase

ACIAD1743

putative oxydoreductase protein, zinc-containing (quinone oxidoreductase, NADPH dependent)

ADH_N, ADH_zinc_N

3NKBY

Cytochrome bd terminal oxidase subunit II

ACIAD1749

cioB

ubiquinol oxidase subunit II, cyanide insensitive

Cyt_bd_oxida_II

Ubiquinol Oxidase

cioA

ubiquinol oxidase subunit I, cyanide insensitive

COG1271

Cyt_bd_oxida_I

K00425

3NPJG

Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism

ACIAD1755

mdcC

malonate decarboxylase, delta subunit

ACP

K13931

3NK2I

FAD binding domain

ACIAD1808

putative monooxygenase

FAD_binding_3

3NTJF

Putative MetA-pathway of phenol degradation

ACIAD1813

conserved hypothetical protein; putative signal peptide

Phenol_MetA_deg

3NMAR

Putative MetA-pathway of phenol degradation

ACIAD1814

conserved hypothetical protein; putative signal peptide

Phenol_MetA_deg

3NQZ7

Acyl-CoA dehydrogenase, middle domain

ACIAD1821

putative acyl-CoA dehydrogenase

Acyl-CoA_dh_1, Acyl-CoA_dh_M, Acyl-CoA_dh_N

1RPXX

Acyl-CoA synthetase (NDP forming)

ACIAD1826

pauA

pimeloyl-CoA synthetase

ATP-grasp_5, CoA_binding_2, Succ_CoA_lig

3NK6K

Luciferase-like monooxygenase

ACIAD1830

putative monooxygenase

Bac_luciferase

3NSWS

NADH:flavin oxidoreductase / NADH oxidase family

ACIAD1836

putative oxidoreductase (NADH-dependent flavin oxidoreductase)

Oxidored_FMN

3NIU1

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily

ACIAD1879

frmA

Alcohol dehydrogenase class 3 (Alcohol dehydrogenase class III) (S-(hydroxymethyl)glutathione dehydrogenase) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH)

COG1062

ADH_N, ADH_zinc_N

K00121

3NJE0

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate

ACIAD1890

fumC

fumarase C (fumarate hydratase Class II)

COG0114

FumaraseC_C, Lyase_1

K01679

3NJ0R

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family

ACIAD1908

nasA

nitrate reductase, large subunit

COG0243

Fer2_BFD, Molybdop_Fe4S4, Molybdopterin, Molydop_binding

K00372

3NK2Y

Rieske-like [2Fe-2S] domain

ACIAD1909

putative nitrate reductase (electron transfer subunit) AND putative nitrite reductase (small subunit)

Pyr_redox_2, Rieske_2

3NK8P

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family

ACIAD1910

nasD

nitrite reductase, large subunit, nucleotide- and Fe/S-cluster binding

COG1251

Fer2_BFD, NIR_SIR, NIR_SIR_ferr, Pyr_redox_2

K00362

3NKKU

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family

ACIAD1915

putative molybdopterin oxidoreductase, alpha subunit (fdhA)

Molybdopterin, Molydop_binding

3NJ6X

Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH

ACIAD1916

fdhD

formate dehydrogenase formation protein

FdhD-NarQ

nitroreductase

nfnB

oxygen-insensitive NADPH nitroreductase

Nitroreductase

Citrate transporter

putative magnesium citrate secondary transporter

COG2851

CitMHS

K03300

3NM9G

Putative MetA-pathway of phenol degradation

ACIAD1936

conserved hypothetical protein; putative signal peptide

Phenol_MetA_deg

3NJ3I

Iron-containing alcohol dehydrogenase

ACIAD1950

putative iron-containing alcohol dehydrogenase

COG0604, COG1064, COG1062, COG1454

Fe-ADH

K00001

3NIGY

alcohol dehydrogenase

ACIAD2015

putative alcohol dehydrogenase

COG1454

Fe-ADH

K13954

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD2018

acoD

Acetaldehyde dehydrogenase 2 (Acetaldehyde dehydrogenase II) (ACDH-II)

COG1012

Aldedh

K00138

3NJ0V

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)

ACIAD2043

conserved hypothetical protein; putative ferredoxin

COG1600

DUF1730, Fer4_16

K18979

3NISQ

Luciferase-like monooxygenase

ACIAD2066

putative monooxygenase (DszA-like)

Bac_luciferase

3NJJ1

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)

ACIAD2098

QueH

Epoxyqueuosine reductase QueH

COG1636

DUF208

K09765

3NJDI

4Fe-4S single cluster domain

ACIAD2207

putative aminomutase (kamA-like)

COG1509

Fer4_14

K19810

3NIFK

Oxidoreductase FAD-binding domain

ACIAD2244

fpr

ferredoxin--NADP+ reductase

COG1018

FAD_binding_6, NAD_binding_1

K00528

3NJBW

Alkyl hydroperoxide reductase

ACIAD2250

ahpF

alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides

COG3634

Pyr_redox_2, Thioredoxin_3

K03387

3NJHT

Soluble pyridine nucleotide transhydrogenase

ACIAD2274

sthA

soluble pyridine nucleotide transhydrogenase (NAD(P)(+) transhydrogenase [B-specific])

COG1249

Pyr_redox_2, Pyr_redox_dim

K00322

3NJCT

Malic enzyme, NAD binding domain

ACIAD2287

maeB

NAD(P)-dependent malic enzyme ; bifunctional: NADP-dependent malic oxidoreductase (N-terminal); phosphotransacetylase (C-terminal)]

COG0280, COG0281

Malic_M, PTA_PTB, malic

K00029

3NK2C

oxidase, subunit

ACIAD2290

cydA

cytochrome d terminal oxidase, polypeptide subunit I

Cyt_bd_oxida_I

oxidase, subunit

cydB

cytochrome d terminal oxidase polypeptide subunit II

COG1294

Cyt_bd_oxida_II

K00426

3NJXI

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA

ACIAD2335

glcB

malate synthase G

COG2225

Malate_synthase

K01638

3NR1D

non-haem dioxygenase in morphine synthesis N-terminal

ACIAD2388

putative oxidoreductase

2OG-FeII_Oxy

3NM2Z

Belongs to the aconitase IPM isomerase family

ACIAD2395

acnB

aconitate hydratase 2

COG1049

Aconitase, Aconitase_2_N, Aconitase_B_N

K01682

3NSGJ

Heavy-metal-associated domain

ACIAD2401

copZ

copper insertion chaperone and transporter component

COG2608

HMA

K07213

3NKWP

Luciferase-like monooxygenase

ACIAD2420

putative monooxygenase

Bac_luciferase

3NK4D

COX Aromatic Rich Motif

ACIAD2425

cyoA

cytochrome o ubiquinol oxidase subunit II

COG1622

COX2, COX_ARM

K02297

3NJ4I

Belongs to the heme-copper respiratory oxidase family

ACIAD2426

cyoB

cytochrome o ubiquinol oxidase subunit I

COG0843

COX1

K02298

3NIPT

Cytochrome c oxidase subunit III

ACIAD2427

cyoC

cytochrome o ubiquinol oxidase subunit III

COG1845

COX3

K02299

3NNHS

Prokaryotic Cytochrome C oxidase subunit IV

ACIAD2428

cyoD

cytochrome o ubiquinol oxidase subunit IV

COX4_pro

GXGXG motif

mgsB

putative N-methyl glutamate synthase subunit B

GXGXG

K22082

3NKKD

Luciferase-like monooxygenase

ACIAD2536

putative coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase

Bac_luciferase

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD2539

tgnE

succinate-semialdehyde dehydrogenase

COG1012

Aldedh

K00135

3NIN2

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid

ACIAD2542

tgnC

MFMB ((Z)-2-((N-methylformamido)methylene)-5-hydroxy-butyrolactone) dehydrogenase

COG1012

Aldedh

K00128

3NK6K

Luciferase-like monooxygenase

ACIAD2543

tgnB

trigonelline monooxygenase, , oxygenase component

Bac_luciferase

3NJZ4

Nitroreductase family

ACIAD2608

putative nitrorecductase

Nitroreductase

3NIEY

Electron transfer flavoprotein

ACIAD2654

etfA

electron transfer flavoprotein alpha-subunit

COG2025

ETF, ETF_alpha

K03522

3NIQV

Electron transfer flavoprotein

ACIAD2655

etfB

electron transfer flavoprotein beta-subunit

COG2086

ETF

K03521

3NK3C

Oxidoreductase FAD-binding domain

ACIAD2671

antC

anthranilate dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase ]

COG0543

FAD_binding_6, Fer2, NAD_binding_1

K11311

3NJSU

Putative MetA-pathway of phenol degradation

ACIAD2673

conserved hypothetical protein; putative signal peptide

Phenol_MetA_deg

3NMD9

oxidoreductase

ACIAD2675

smoA

styrene monooxygenase

3NKZF

FAD binding domain

ACIAD2721

conserved hypothetical protein; putative hydrolase/monooxygenase

FAD_binding_3

3NKMZ

NADH:flavin oxidoreductase / NADH oxidase family

ACIAD2725

putative oxidoreductase, NADH-dependent flavin oxidoreductase

Oxidored_FMN

3NT08

Zinc-binding dehydrogenase

ACIAD2738

putative NADPH:quinone reductase and related Zn-dependent oxidoreductase

COG0604

ADH_N, ADH_zinc_N

K00344

3NK4I

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

ACIAD2755

putative methyl-cis-aconitic acid hydratase (AcnM)

COG1048

Aconitase, Aconitase_C

K20455

3NKGX

Belongs to the citrate synthase family

ACIAD2756

prpC

methylcitrate synthase (citrate synthase 2)

Citrate_synt

Citrate transporter

citN

citrate transporter

COG2851

CitMHS

K03300

3NK4S

CoA-transferase family III

ACIAD2821

putative CoA transferase

CoA_transf_3

3NJM2

C-terminal domain of alpha-glycerophosphate oxidase

ACIAD2844

glpD

glycerol-3-phosphate dehydrogenase

COG0578

DAO, DAO_C

K00111

3NKDR

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit

ACIAD2872

sucD

succinyl-CoA synthetase alpha chain

COG0074

CoA_binding, Ligase_CoA

K01902

3NIRD

COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

ACIAD2874

lpd

dihydrolipoamide dehydrogenase E3 subunit of 2-oxoglutarate dehydrogenase complex (Glycine oxidation system L-factor)

COG1249

Pyr_redox_2, Pyr_redox_dim

K00382

3NIMS

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)

ACIAD2875

sucB

dihydrolipoamide succinyltransferase, E2 component of 2-oxoglutarate dehydrogenase complex

COG0508

2-oxoacid_dh, Biotin_lipoyl, E3_binding

K00658

3NIYG

COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes

ACIAD2876

sucA

2-oxoglutarate decarboxylase E1 component of the 2-oxoglutarate dehydrogenase complex

COG0567

2-oxogl_dehyd_N, E1_dh, OxoGdeHyase_C, Transket_pyr

K00164

3NIGB

succinate dehydrogenase

ACIAD2879

sdhB

succinate dehydrogenase, iron-sulfur subunit

COG0479

Fer2_3, Fer4_8

K00240

3NJNU

Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily

ACIAD2880

sdhA

succinate dehydrogenase, flavoprotein subunit

COG1053

FAD_binding_2, Succ_DH_flav_C

K00239

3NNHR

Succinate dehydrogenase hydrophobic membrane anchor subunit

ACIAD2881

sdhD

succinate dehydrogenase, hydrophobic subunit

COG2142

Sdh_cyt

K00242

3NNJ6

succinate dehydrogenase

ACIAD2882

sdhC

succinate dehydrogenase, cytochrome b556 subunit

COG2009

Sdh_cyt

K00241

3NKP2

Belongs to the citrate synthase family

ACIAD2886

gltA

citrate synthase

Citrate_synt

Ferredoxin

putative ferredoxin [4Fe-4S] (Fdx)

Fer4

3NJYF

Iron-containing alcohol dehydrogenase

ACIAD2929

putative alcohol dehydrogenase

COG0604, COG1064, COG1062, COG1454

Fe-ADH

K00001

3NKEQ

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family

ACIAD2982

cysI

Sulfite reductase (NADPH) hemoprotein beta-component

COG0155

NIR_SIR, NIR_SIR_ferr

K00381

3NJIN

CoA-transferase family III

ACIAD2985

putative acyl-CoA transferase

CoA_transf_3

3NJ3M

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

ACIAD3078

pntB

pyridine nucleotide transhydrogenase, beta subunit

COG1282

PNTB

K00325

3NNJ0

4TM region of pyridine nucleotide transhydrogenase, mitoch

ACIAD3079

pntA-2

pyridine nucleotide transhydrogenase (proton pump), alpha subunit (part2)

COG3288

PNTB_4TM

K00324

3NJZX

Alanine dehydrogenase/PNT, N-terminal domain

ACIAD3080

pntA-1

pyridine nucleotide transhydrogenase (proton pump), alpha subunit (part1)

COG3288

AlaDh_PNT_C, AlaDh_PNT_N

K00324

3NKPZ

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

ACIAD3090

acnA

aconitate hydratase 1

COG0065, COG1048

Aconitase, Aconitase_C

K01681

3NT27

Aldo/keto reductase family

ACIAD3128

putative oxidoreductase

Aldo_ket_red

3NK4N

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

ACIAD3145

putative dihydrolipoamide dehydrogenase E3 component of pyruvate/2-oxoglutarate dehydrogenase complex

COG1249

Pyr_redox_2, Pyr_redox_dim

K00382

3NIHG

Catalyzes the reversible oxidation of malate to oxaloacetate

ACIAD3155

mdh

malate dehydrogenase

Ldh_1_C, Ldh_1_N

Globin

putative flavohemoprotein

Globin

3NK8K

Electron transfer flavoprotein-ubiquinone oxidoreductase

ACIAD3259

etfD

electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring-flavoprotein dehydrogenase)

COG0644

ETF_QO, FAD_binding_2

K00311

3NJ61

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

ACIAD3278

hprA

glycerate dehydrogenase

COG1052

2-Hacid_dh, 2-Hacid_dh_C

K00018

3NJUR