BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: afc8b2ceb6efce5e789378a49a2612e3.SwissProt.fasta
           22 sequences; 5,778 total letters



Query= Z4448

Length=264
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P0ACL4 Exu regulon transcriptional regulator [Shigella flexneri]      521     0.0   
P0ACL2 Exu regulon transcriptional regulator [Escherichia coli (s...  521     0.0   
P0ACL3 Exu regulon transcriptional regulator [Escherichia coli O1...  521     0.0   
Q9X9E0 Exu regulon transcriptional regulator [Dickeya chrysanthemi]   410     8e-150
P39161 Uxu operon transcriptional regulator [Escherichia coli (st...  204     9e-69 
P44487 Uxu operon regulator [Haemophilus influenzae (strain ATCC ...  197     4e-66 
P0ACL8 Putative L-lactate dehydrogenase operon regulatory protein...  78.2    2e-20 
P0ACL7 Putative L-lactate dehydrogenase operon regulatory protein...  78.2    2e-20 
P42239 Uncharacterized HTH-type transcriptional regulator YcbG [B...  72.4    2e-18 
P0ACL6 Glc operon transcriptional activator [Escherichia coli O6:...  70.9    9e-18 
P0ACL5 Glc operon transcriptional activator [Escherichia coli (st...  70.9    9e-18 
O07007 HTH-type transcriptional regulator LutR [Bacillus subtilis...  67.4    1e-16 
P0CL10 Pyruvate dehydrogenase complex repressor [Salmonella typhi...  63.5    3e-15 
E1W823 Pyruvate dehydrogenase complex repressor [Salmonella typhi...  63.5    3e-15 
P0A2S3 Pyruvate dehydrogenase complex repressor [Salmonella typhi]    63.5    3e-15 
P0ACM0 Pyruvate dehydrogenase complex repressor [Escherichia coli...  62.8    6e-15 
P0ACM1 Pyruvate dehydrogenase complex repressor [Escherichia coli...  62.8    6e-15 
P0ACL9 Pyruvate dehydrogenase complex repressor [Escherichia coli...  62.8    6e-15 
Q796Q6 Uncharacterized HTH-type transcriptional regulator YisV [B...  50.4    2e-10 
P0A8W0 HTH-type transcriptional repressor NanR [Escherichia coli ...  49.3    3e-10 
O31459 HTH-type transcriptional repressor GamR [Bacillus subtilis...  48.1    6e-10 
P9WMG5 HTH-type transcriptional regulator Mce2R [Mycobacterium tu...  45.8    3e-09 


>P0ACL4 Exu regulon transcriptional regulator [Shigella flexneri]
Length=258

 Score = 521 bits (1342),  Expect = 0.0
 Identities = 258/258 (100%), Positives = 258/258 (100%), Gaps = 0/258 (0%)

Query  6    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  65
            MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
Sbjct  1    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  60

Query  66   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  125
            YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
Sbjct  61   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  120

Query  126  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  185
            IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
Sbjct  121  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  180

Query  186  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  245
            EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
Sbjct  181  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  240

Query  246  LFAENPVVHLDTATSGSK  263
            LFAENPVVHLDTATSGSK
Sbjct  241  LFAENPVVHLDTATSGSK  258


>P0ACL2 Exu regulon transcriptional regulator [Escherichia coli 
(strain K12)]
Length=258

 Score = 521 bits (1342),  Expect = 0.0
 Identities = 258/258 (100%), Positives = 258/258 (100%), Gaps = 0/258 (0%)

Query  6    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  65
            MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
Sbjct  1    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  60

Query  66   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  125
            YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
Sbjct  61   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  120

Query  126  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  185
            IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
Sbjct  121  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  180

Query  186  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  245
            EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
Sbjct  181  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  240

Query  246  LFAENPVVHLDTATSGSK  263
            LFAENPVVHLDTATSGSK
Sbjct  241  LFAENPVVHLDTATSGSK  258


>P0ACL3 Exu regulon transcriptional regulator [Escherichia coli 
O157:H7]
Length=258

 Score = 521 bits (1342),  Expect = 0.0
 Identities = 258/258 (100%), Positives = 258/258 (100%), Gaps = 0/258 (0%)

Query  6    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  65
            MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
Sbjct  1    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  60

Query  66   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  125
            YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
Sbjct  61   YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD  120

Query  126  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  185
            IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
Sbjct  121  IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH  180

Query  186  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  245
            EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
Sbjct  181  EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY  240

Query  246  LFAENPVVHLDTATSGSK  263
            LFAENPVVHLDTATSGSK
Sbjct  241  LFAENPVVHLDTATSGSK  258


>Q9X9E0 Exu regulon transcriptional regulator [Dickeya chrysanthemi]
Length=259

 Score = 410 bits (1053),  Expect = 8e-150
 Identities = 201/257 (78%), Positives = 229/257 (89%), Gaps = 1/257 (0%)

Query  6    MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG  65
            M +TE RRLYQQLAA+LK+RIE GVY VGDKLPAER I++E NVSRTVVREAIIMLEVEG
Sbjct  1    MALTESRRLYQQLAAELKQRIENGVYPVGDKLPAERNISEEMNVSRTVVREAIIMLEVEG  60

Query  66   YVEVRKGSGIHVVSNQPRHQQAAD-NNMEFANYGPFELLQARQLIESNIAEFAATQVTKQ  124
            YVEVRKGSGIHV+SNQ RH  AA+ ++ +F   GPFELLQARQLIESNIAEFAATQVT+Q
Sbjct  61   YVEVRKGSGIHVISNQQRHLLAANGSDADFLTAGPFELLQARQLIESNIAEFAATQVTRQ  120

Query  125  DIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKL  184
            DI++LM IQE AR E  FRDSEWDL+FH+QVALATQNSA+A IVEKMW+QR HNPYW+KL
Sbjct  121  DIIQLMEIQENARQEDRFRDSEWDLKFHVQVALATQNSAMATIVEKMWSQRIHNPYWRKL  180

Query  185  HEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADR  244
            HEHID +++++WC+DHDQILKALIRKDP+AAKLAMWQHLENTK MLF  T+DDFEFN DR
Sbjct  181  HEHIDDKSIESWCEDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFRATTDDFEFNVDR  240

Query  245  YLFAENPVVHLDTATSG  261
            Y+FAENPVVHLD  T+G
Sbjct  241  YMFAENPVVHLDHITNG  257


>P39161 Uxu operon transcriptional regulator [Escherichia coli 
(strain K12)]
Length=257

 Score = 204 bits (519),  Expect = 9e-69
 Identities = 118/254 (46%), Positives = 162/254 (64%), Gaps = 8/254 (3%)

Query  9    TEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVE  68
            T  +R YQ++ A +++ I +  Y  G++LP ER IA+  +V+RTVVREA+IMLE++G VE
Sbjct  5    TSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVE  64

Query  69   VRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMK  128
            VR+G+GI+V+ N       + +     + GPFELLQARQL+ESNIAEFAA Q T++DI+K
Sbjct  65   VRRGAGIYVLDNSGSQNTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVK  124

Query  129  L---MAIQEQARGEQCFRDSE-WDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKL  184
            +   + ++E+         SE  D+QFH+ +A AT NS L  +  + W  R +NP W +L
Sbjct  125  MRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNPMWIQL  184

Query  185  HEHI-DSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETS-DDFEFNA  242
            H H+ DS     W  DH QIL ALI+KD  AAKLAMWQHLEN K  L   ++ DD  F  
Sbjct  185  HSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDIYF--  242

Query  243  DRYLFAENPVVHLD  256
            D YLF   P+  +D
Sbjct  243  DGYLFDSWPLDKVD  256


>P44487 Uxu operon regulator [Haemophilus influenzae (strain ATCC 
51907 / DSM 11121 / KW20 / Rd)]
Length=266

 Score = 197 bits (502),  Expect = 4e-66
 Identities = 114/245 (47%), Positives = 157/245 (64%), Gaps = 9/245 (4%)

Query  13   RLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKG  72
            R Y ++   LK+ I QG+Y +GDKLP ER I+++  VSRT+VREA++MLEVE  VEV+KG
Sbjct  24   RTYTRIGQLLKQDISQGIYSIGDKLPTEREISEKFGVSRTIVREAMVMLEVEKLVEVKKG  83

Query  73   SGIHVV-SNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMA  131
            SG++VV + +  H + +D      + GPFELLQARQL+ES+IAEFAA Q TK+DI+ L  
Sbjct  84   SGVYVVRTPESIHMEHSD----LPDVGPFELLQARQLLESSIAEFAALQATKKDILNLKQ  139

Query  132  I--QEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLHEHID  189
            I  +E+    Q   D   D  FH+ +A  TQN  L  + E++W  R ++  W +LH  I 
Sbjct  140  ILNREKELLTQNQDDYSADKDFHLALAEITQNDVLVKLQEQLWQYRFNSAMWAQLHSRIL  199

Query  190  SRTVDN-WCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRYLFA  248
                 + W +DH  IL A+ +K+ + A+ AMWQHLEN K+ LF E SD  + + D YLF 
Sbjct  200  QNDYHHLWIEDHQTILSAIQKKNANEARKAMWQHLENVKVKLF-ELSDVEDPHFDGYLFN  258

Query  249  ENPVV  253
             NPVV
Sbjct  259  TNPVV  263


>P0ACL8 Putative L-lactate dehydrogenase operon regulatory protein 
[Shigella flexneri]
Length=258

 Score = 78.2 bits (191),  Expect = 2e-20
 Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 15/237 (6%)

Query  8    ITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYV  67
            I  PRRL  ++A  ++  I++     G KLPAER +A +  VSR  +REA+  L  EG +
Sbjct  2    IVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVL  61

Query  68   EVRKGSGIHVVSNQPRHQQAADNNM---------EFANYGPFELLQARQLIESNIAEFAA  118
              R+G G  +   + RH   ++ N+         +  +Y  F++L+AR  IE++ A  AA
Sbjct  62   LSRRGGGTFI---RWRHDTWSEQNIVQPLKTLMADDPDYS-FDILEARYAIEASTAWHAA  117

Query  119  TQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHN  178
             + T  D  K+    E    E     S+ D++FH+ +A A+ N  L   +   +     +
Sbjct  118  MRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSS  177

Query  179  PYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLE--NTKIMLFNE  233
                +   ++         + H  ++ A+   D   A+ AM  HL   +T +  F+E
Sbjct  178  VKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDE  234


>P0ACL7 Putative L-lactate dehydrogenase operon regulatory protein 
[Escherichia coli (strain K12)]
Length=258

 Score = 78.2 bits (191),  Expect = 2e-20
 Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 15/237 (6%)

Query  8    ITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYV  67
            I  PRRL  ++A  ++  I++     G KLPAER +A +  VSR  +REA+  L  EG +
Sbjct  2    IVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVL  61

Query  68   EVRKGSGIHVVSNQPRHQQAADNNM---------EFANYGPFELLQARQLIESNIAEFAA  118
              R+G G  +   + RH   ++ N+         +  +Y  F++L+AR  IE++ A  AA
Sbjct  62   LSRRGGGTFI---RWRHDTWSEQNIVQPLKTLMADDPDYS-FDILEARYAIEASTAWHAA  117

Query  119  TQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHN  178
             + T  D  K+    E    E     S+ D++FH+ +A A+ N  L   +   +     +
Sbjct  118  MRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSS  177

Query  179  PYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLE--NTKIMLFNE  233
                +   ++         + H  ++ A+   D   A+ AM  HL   +T +  F+E
Sbjct  178  VKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDE  234


>P42239 Uncharacterized HTH-type transcriptional regulator YcbG 
[Bacillus subtilis (strain 168)]
Length=233

 Score = 72.4 bits (176),  Expect = 2e-18
 Identities = 51/213 (24%), Positives = 95/213 (45%), Gaps = 8/213 (4%)

Query  12   RRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRK  71
            + L +Q+   +   +  G    GDKLP E  + D  +VSR V+REA+  LE  G +  + 
Sbjct  16   KTLAKQVIERIVHLLSSGQLRAGDKLPTEMELMDILHVSRPVLREALSSLETLGVITRKT  75

Query  72   GSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMA  131
              G +   N     Q     +  A      +++AR  +E  +   AA ++ ++++ +L  
Sbjct  76   RGGTYF--NDKIGMQPFSVMLALATDNLPAIIEARMALELGLVTIAAEKINEEELQRLQK  133

Query  132  IQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLHEHIDSR  191
              +           E D +FH  +AL+  N  +  +++ +    +      K+   I  R
Sbjct  134  TIDDIANSTDNHYGEADKEFHRIIALSANNPVVEGMIQSLLITHA------KIDSQIPYR  187

Query  192  TVDNWCDDHDQILKALIRKDPHAAKLAMWQHLE  224
              D   + H +I  AL ++DP+ A   M++HL+
Sbjct  188  ERDVTVEYHKKIYDALAKRDPYKAHYHMYEHLK  220


 Score = 18.5 bits (36),  Expect = 2.9
 Identities = 14/38 (37%), Positives = 18/38 (47%), Gaps = 5/38 (13%)

Query  221  QHLENTKIMLFNETSD-----DFEFNADRYLFAENPVV  253
            Q L+ T   + N T +     D EF+    L A NPVV
Sbjct  129  QRLQKTIDDIANSTDNHYGEADKEFHRIIALSANNPVV  166


>P0ACL6 Glc operon transcriptional activator [Escherichia coli 
O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=254

 Score = 70.9 bits (172),  Expect = 9e-18
 Identities = 59/244 (24%), Positives = 102/244 (42%), Gaps = 44/244 (18%)

Query  10   EPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEV  69
            E R + + +A  ++  I  GV  VG  LP+ER + ++   SR+ +RE + +L   G +E 
Sbjct  4    ERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGIIET  63

Query  70   RKGSG---------------IHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIA  114
             +G                 IH+ S QPR                ++LL  R L+E   A
Sbjct  64   AQGRDSRVARLNRVQDTSPLIHLFSTQPRTL--------------YDLLDVRALLEGESA  109

Query  115  EFAATQVTKQDIM-------KLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAI  167
              AAT  T+ D +       K++A  E  +       ++ D  FH+ +  A+ N  L   
Sbjct  110  RLAATLGTQADFVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQASHNQVLVFT  169

Query  168  VEKMWTQRSHNPYWKKL----HEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHL  223
            ++ + T    N  +  +    H     + +D     H +I  A++++ PH A+ A   H+
Sbjct  170  LQSL-TDLMFNSVFASVNNLYHRPQQKKQIDR---QHARIYNAVLQRLPHVAQRAARDHV  225

Query  224  ENTK  227
               K
Sbjct  226  RTVK  229


 Score = 19.2 bits (38),  Expect = 1.7
 Identities = 8/17 (47%), Positives = 10/17 (59%), Gaps = 0/17 (0%)

Query  2   PGAHMEITEPRRLYQQL  18
           P  H+  T+PR LY  L
Sbjct  82  PLIHLFSTQPRTLYDLL  98


>P0ACL5 Glc operon transcriptional activator [Escherichia coli 
(strain K12)]
Length=254

 Score = 70.9 bits (172),  Expect = 9e-18
 Identities = 59/244 (24%), Positives = 102/244 (42%), Gaps = 44/244 (18%)

Query  10   EPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEV  69
            E R + + +A  ++  I  GV  VG  LP+ER + ++   SR+ +RE + +L   G +E 
Sbjct  4    ERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGIIET  63

Query  70   RKGSG---------------IHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIA  114
             +G                 IH+ S QPR                ++LL  R L+E   A
Sbjct  64   AQGRDSRVARLNRVQDTSPLIHLFSTQPRTL--------------YDLLDVRALLEGESA  109

Query  115  EFAATQVTKQDIM-------KLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAI  167
              AAT  T+ D +       K++A  E  +       ++ D  FH+ +  A+ N  L   
Sbjct  110  RLAATLGTQADFVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQASHNQVLVFT  169

Query  168  VEKMWTQRSHNPYWKKL----HEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHL  223
            ++ + T    N  +  +    H     + +D     H +I  A++++ PH A+ A   H+
Sbjct  170  LQSL-TDLMFNSVFASVNNLYHRPQQKKQIDR---QHARIYNAVLQRLPHVAQRAARDHV  225

Query  224  ENTK  227
               K
Sbjct  226  RTVK  229


 Score = 19.2 bits (38),  Expect = 1.7
 Identities = 8/17 (47%), Positives = 10/17 (59%), Gaps = 0/17 (0%)

Query  2   PGAHMEITEPRRLYQQL  18
           P  H+  T+PR LY  L
Sbjct  82  PLIHLFSTQPRTLYDLL  98


>O07007 HTH-type transcriptional regulator LutR [Bacillus subtilis 
(strain 168)]
Length=219

 Score = 67.4 bits (163),  Expect = 1e-16
 Identities = 61/218 (28%), Positives = 107/218 (49%), Gaps = 22/218 (10%)

Query  26   IEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVS---NQP  82
            I+ G    GDKL + + +A+   VSR+ VREA+  L+  G VE+++G G ++     NQ 
Sbjct  2    IKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVEMKQGEGTYLKEFELNQI  61

Query  83   RHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLM-AIQE----QAR  137
                +A   M+  +    +LL+ R+L+E  +A  AA + T+ D+ ++  A++E    +A 
Sbjct  62   SQPLSAALLMKKEDVK--QLLEVRKLLEIGVASLAAEKRTEADLERIQDALKEMGSIEAD  119

Query  138  GEQCFRDSEWDLQFHIQVALATQNSALAAIVEK-----MWTQRSHNPYWKKLHEHIDSRT  192
            GE      + D  FH+ +A A+QN  L  ++       + T R     W          +
Sbjct  120  GE---LGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRETRKIWL----FSKKTS  172

Query  193  VDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIML  230
            V    ++H++I  A+   +   A+ AM  HL N + +L
Sbjct  173  VQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVL  210


>P0CL10 Pyruvate dehydrogenase complex repressor [Salmonella typhimurium 
(strain LT2 / SGSC1412 / ATCC 700720)]
Length=254

 Score = 63.5 bits (153),  Expect = 3e-15
 Identities = 63/241 (26%), Positives = 111/241 (46%), Gaps = 10/241 (4%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   F+LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+          +SE  LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSD  236
             N        +     +        +I +A++   P  A+ A  +HL   + ++ + + +
Sbjct  179  QNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSRE  238

Query  237  D  237
            +
Sbjct  239  E  239


>E1W823 Pyruvate dehydrogenase complex repressor [Salmonella typhimurium 
(strain SL1344)]
Length=254

 Score = 63.5 bits (153),  Expect = 3e-15
 Identities = 63/241 (26%), Positives = 111/241 (46%), Gaps = 10/241 (4%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   F+LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+          +SE  LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSD  236
             N        +     +        +I +A++   P  A+ A  +HL   + ++ + + +
Sbjct  179  QNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSRE  238

Query  237  D  237
            +
Sbjct  239  E  239


>P0A2S3 Pyruvate dehydrogenase complex repressor [Salmonella typhi]
Length=254

 Score = 63.5 bits (153),  Expect = 3e-15
 Identities = 63/241 (26%), Positives = 111/241 (46%), Gaps = 10/241 (4%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   F+LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+          +SE  LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSD  236
             N        +     +        +I +A++   P  A+ A  +HL   + ++ + + +
Sbjct  179  QNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSRE  238

Query  237  D  237
            +
Sbjct  239  E  239


>P0ACM0 Pyruvate dehydrogenase complex repressor [Escherichia 
coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=254

 Score = 62.8 bits (151),  Expect = 6e-15
 Identities = 65/243 (27%), Positives = 116/243 (48%), Gaps = 14/243 (6%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   ++LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+   +      +S   LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSR--TVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNET  234
             N   ++  E + SR   +        +I +A++   P  A+ A  +HL   + +L + +
Sbjct  179  QNV--RQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRS  236

Query  235  SDD  237
             ++
Sbjct  237  REE  239


>P0ACM1 Pyruvate dehydrogenase complex repressor [Escherichia 
coli O157:H7]
Length=254

 Score = 62.8 bits (151),  Expect = 6e-15
 Identities = 65/243 (27%), Positives = 116/243 (48%), Gaps = 14/243 (6%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   ++LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+   +      +S   LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSR--TVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNET  234
             N   ++  E + SR   +        +I +A++   P  A+ A  +HL   + +L + +
Sbjct  179  QNV--RQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRS  236

Query  235  SDD  237
             ++
Sbjct  237  REE  239


>P0ACL9 Pyruvate dehydrogenase complex repressor [Escherichia 
coli (strain K12)]
Length=254

 Score = 62.8 bits (151),  Expect = 6e-15
 Identities = 65/243 (27%), Positives = 116/243 (48%), Gaps = 14/243 (6%)

Query  4    AHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEV  63
            A+ +I +P+ L   +   L+  I +G    G+KLP ER +A + +VSR  +REAI  LE 
Sbjct  2    AYSKIRQPK-LSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA  60

Query  64   EGYVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGP---FELLQARQLIESNIAEFAATQ  120
            +G +  R+G G  V S+    Q  +D  +E  +  P   ++LL+ R  +E   A +AA +
Sbjct  61   KGLLLRRQGGGTFVQSS--LWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALR  118

Query  121  VTKQDIMKLM----AIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRS  176
             T +D  ++     AI+   +      +S   LQ+ I V  A  N  L  ++  M    +
Sbjct  119  STDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLA  178

Query  177  HNPYWKKLHEHIDSR--TVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNET  234
             N   ++  E + SR   +        +I +A++   P  A+ A  +HL   + +L + +
Sbjct  179  QNV--RQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRS  236

Query  235  SDD  237
             ++
Sbjct  237  REE  239


>Q796Q6 Uncharacterized HTH-type transcriptional regulator YisV 
[Bacillus subtilis (strain 168)]
Length=484

 Score = 50.4 bits (119),  Expect = 2e-10
 Identities = 26/67 (39%), Positives = 43/67 (64%), Gaps = 0/67 (0%)

Query  14  LYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGS  73
           L++Q+   +K++I  G + VG K+P++R +AD   V+R+ V  AI  L  +G +E RKG 
Sbjct  16  LHRQIEQYMKDKILHGEWAVGTKIPSQRTLADMFQVNRSTVTAAIDELTSQGLLEGRKGG  75

Query  74  GIHVVSN  80
           G  VV++
Sbjct  76  GTKVVNS  82


>P0A8W0 HTH-type transcriptional repressor NanR [Escherichia coli 
(strain K12)]
Length=263

 Score = 49.3 bits (116),  Expect = 3e-10
 Identities = 58/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)

Query  12   RRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRK  71
            ++L + +  +L++ I +  +  G++LP+ER +    NV R  VREA+  L+ +G V++  
Sbjct  30   KKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINN  89

Query  72   GSGIHV--VSNQPRHQQAADNNMEFANY--GPFELLQARQLIESNIAEFAATQVTKQDI-  126
            G    V   S      + +    +F ++  G     Q R   ES++  +AA   T + I 
Sbjct  90   GERARVSRPSADTIIGELSGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQID  149

Query  127  --MKLMAIQEQA-RGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKM--WTQRSHNPYW  181
               K + I  Q+      F  S  D+ FH  +A    N    AI   +  W   +     
Sbjct  150  LLAKALEINSQSLDNNAAFIRS--DVDFHRVLAEIPGNPIFMAIHVALLDWLIAARPTVT  207

Query  182  -KKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLEN  225
             + LHEH +          H  I+ A+ R DP  A  A+  HL +
Sbjct  208  DQALHEHNNVS-----YQQHIAIVDAIRRHDPDEADRALQSHLNS  247


>O31459 HTH-type transcriptional repressor GamR [Bacillus subtilis 
(strain 168)]
Length=235

 Score = 48.1 bits (113),  Expect = 6e-10
 Identities = 25/64 (39%), Positives = 37/64 (58%), Gaps = 0/64 (0%)

Query  14  LYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGS  73
           LY  +   + E I+ G Y   D+LP E    ++ +VSRT VR A+  LE+EGY++  +G 
Sbjct  4   LYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTVRLALQQLELEGYIKRIQGK  63

Query  74  GIHV  77
           G  V
Sbjct  64  GTFV  67


>P9WMG5 HTH-type transcriptional regulator Mce2R [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=240

 Score = 45.8 bits (107),  Expect = 3e-09
 Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 5/106 (5%)

Query  11   PRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVR  70
            P  +++Q+A D    +  G    G+ LP+ER +A+   VSR  VREA+  L   G VEVR
Sbjct  12   PEEVFEQIATD----VLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVR  67

Query  71   KGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEF  116
            +G  +  V +  RH             G  ++   R ++E+ +  F
Sbjct  68   QGD-VTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNF  112



Lambda      K        H        a         alpha
   0.321    0.133    0.394    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1048572


  Database: afc8b2ceb6efce5e789378a49a2612e3.SwissProt.fasta
    Posted date:  May 20, 2024  6:42 AM
  Number of letters in database: 5,778
  Number of sequences in database:  22



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40