Comparative Genomics

Z3565 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: a0b71d7853a3026821bee178ab93a7dd.SwissProt.fasta
           13 sequences; 2,725 total letters



Query= Z3565

Length=121
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P0AC22 Dihydroneopterin triphosphate 2'-epimerase [Shigella flexn...  240     2e-87
P0AC20 Dihydroneopterin triphosphate 2'-epimerase [Escherichia co...  240     2e-87
P0AC21 Dihydroneopterin triphosphate 2'-epimerase [Escherichia co...  240     2e-87
P0AC19 Dihydroneopterin triphosphate 2'-epimerase [Escherichia co...  240     2e-87
P0AC18 Dihydroneopterin aldolase [Shigella flexneri]                  56.6    4e-15
P0AC17 Dihydroneopterin aldolase [Escherichia coli O6:H1 (strain ...  56.6    4e-15
P0AC16 Dihydroneopterin aldolase [Escherichia coli (strain K12)]      56.6    4e-15
P29251 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropte...  55.8    7e-14
Q54YD9 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropte...  46.2    2e-10
P74342 Probable dihydroneopterin aldolase [Synechocystis sp. (str...  41.6    2e-09
Q8CMT8 Dihydroneopterin aldolase [Staphylococcus epidermidis (str...  41.2    3e-09
Q5HRN9 Dihydroneopterin aldolase [Staphylococcus epidermidis (str...  41.2    3e-09
Q9PJC6 Probable dihydroneopterin aldolase [Chlamydia muridarum (s...  40.4    6e-09


>P0AC22 Dihydroneopterin triphosphate 2'-epimerase [Shigella flexneri]
Length=120

 Score = 240 bits (612),  Expect = 2e-87
 Identities = 120/120 (100%), Positives = 120/120 (100%), Gaps = 0/120 (0%)

Query  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60
            MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV
Sbjct  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60

Query  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120
            TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
Sbjct  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120


>P0AC20 Dihydroneopterin triphosphate 2'-epimerase [Escherichia 
coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=120

 Score = 240 bits (612),  Expect = 2e-87
 Identities = 120/120 (100%), Positives = 120/120 (100%), Gaps = 0/120 (0%)

Query  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60
            MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV
Sbjct  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60

Query  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120
            TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
Sbjct  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120


>P0AC21 Dihydroneopterin triphosphate 2'-epimerase [Escherichia 
coli O157:H7]
Length=120

 Score = 240 bits (612),  Expect = 2e-87
 Identities = 120/120 (100%), Positives = 120/120 (100%), Gaps = 0/120 (0%)

Query  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60
            MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV
Sbjct  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60

Query  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120
            TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
Sbjct  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120


>P0AC19 Dihydroneopterin triphosphate 2'-epimerase [Escherichia 
coli (strain K12)]
Length=120

 Score = 240 bits (612),  Expect = 2e-87
 Identities = 120/120 (100%), Positives = 120/120 (100%), Gaps = 0/120 (0%)

Query  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60
            MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV
Sbjct  1    MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV  60

Query  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120
            TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
Sbjct  61   TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR  120


>P0AC18 Dihydroneopterin aldolase [Shigella flexneri]
Length=122

 Score = 56.6 bits (135),  Expect = 4e-15
 Identities = 28/110 (25%), Positives = 61/110 (55%), Gaps = 0/110 (0%)

Query  7    IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
            I+ I+ L + T IG+ + E    Q +V ++ + +   KA  S+D+ D L+Y  + + ++ 
Sbjct  3    IVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVS  62

Query  67   HVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTL  116
            HVE  RF+L+E++ ++V ++        +  +++ K  A+  A +V + +
Sbjct  63   HVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVII  112


>P0AC17 Dihydroneopterin aldolase [Escherichia coli O6:H1 (strain 
CFT073 / ATCC 700928 / UPEC)]
Length=122

 Score = 56.6 bits (135),  Expect = 4e-15
 Identities = 28/110 (25%), Positives = 61/110 (55%), Gaps = 0/110 (0%)

Query  7    IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
            I+ I+ L + T IG+ + E    Q +V ++ + +   KA  S+D+ D L+Y  + + ++ 
Sbjct  3    IVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVS  62

Query  67   HVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTL  116
            HVE  RF+L+E++ ++V ++        +  +++ K  A+  A +V + +
Sbjct  63   HVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVII  112


>P0AC16 Dihydroneopterin aldolase [Escherichia coli (strain K12)]
Length=122

 Score = 56.6 bits (135),  Expect = 4e-15
 Identities = 28/110 (25%), Positives = 61/110 (55%), Gaps = 0/110 (0%)

Query  7    IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
            I+ I+ L + T IG+ + E    Q +V ++ + +   KA  S+D+ D L+Y  + + ++ 
Sbjct  3    IVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVS  62

Query  67   HVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTL  116
            HVE  RF+L+E++ ++V ++        +  +++ K  A+  A +V + +
Sbjct  63   HVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVII  112


>P29251 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropterin 
pyrophosphokinase / Dihydropteroate synthase [Pneumocystis 
carinii]
Length=740

 Score = 55.8 bits (133),  Expect = 7e-14
 Identities = 34/108 (31%), Positives = 57/108 (53%), Gaps = 1/108 (1%)

Query  10   IKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSED-INDALNYRTVTKNIIQHV  68
            IKNL L T IGI  EE  N+Q+I+I++ +   +      +D I +  N   + K I++HV
Sbjct  165  IKNLSLYTIIGINPEERVNKQNIIIDLILFKSSINLECKDDFIINTYNIEKLLKEIVKHV  224

Query  69   ENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTL  116
            E + F  +E L   +  I+   H +    V++ K  AL +A+S  + +
Sbjct  225  EESTFKTIEALALSIARISCISHNIEKIIVKVKKSCALAFAESAGVEI  272


 Score = 39.3 bits (90),  Expect = 4e-08
 Identities = 23/91 (25%), Positives = 50/91 (55%), Gaps = 4/91 (4%)

Query  7    IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
            +I I +L L++ +G         Q +V+ +++   A  +   +D++ +++Y TV K + +
Sbjct  40   LIHIHSLTLKSIVGKNSWAQRLLQPVVLTLSMGINASLSGNMDDLSYSIDYATVYKEVFK  99

Query  67   HVENNRF----SLLEKLTQDVLDIAREHHWV  93
             VEN++F     L +K+++ VL    + +WV
Sbjct  100  LVENSKFENLLDLSDKISKVVLGDKCKGNWV  130


>Q54YD9 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropterin 
pyrophosphokinase / Dihydropteroate synthase [Dictyostelium 
discoideum]
Length=657

 Score = 46.2 bits (108),  Expect = 2e-10
 Identities = 28/102 (27%), Positives = 55/102 (54%), Gaps = 0/102 (0%)

Query  8    IRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQH  67
            I IK+L ++  IG+   E   +Q+I+I+VT +    K  +S+++ D ++Y +++K+I  +
Sbjct  4    IIIKDLLIQAVIGVNPGERIIKQNIIISVTAYKDLSKCGSSDNVIDTVSYSSLSKSICSY  63

Query  68   VENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYA  109
             E++    LE L   V  I      +   +V + K  A++ A
Sbjct  64   SESSHHYTLEALATGVAKICCLGFGIERVKVLVQKPGAIKLA  105


>P74342 Probable dihydroneopterin aldolase [Synechocystis sp. 
(strain PCC 6803 / Kazusa)]
Length=118

 Score = 41.6 bits (96),  Expect = 2e-09
 Identities = 21/78 (27%), Positives = 40/78 (51%), Gaps = 0/78 (0%)

Query  8   IRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQH  67
           + +K +R   + G  + E    Q   +++TI     KA  S+D+ND LNY      + + 
Sbjct  4   LNVKGIRAYGYTGYFDAEQFLGQWFEVDLTIWIDLAKAGQSDDLNDTLNYADAVAIVQKL  63

Query  68  VENNRFSLLEKLTQDVLD  85
           +  ++F ++EKL + + D
Sbjct  64  IRESKFKMIEKLAEAIAD  81


 Score = 16.5 bits (31),  Expect = 1.9
 Identities = 9/25 (36%), Positives = 16/25 (64%), Gaps = 2/25 (8%)

Query  92   WVTYAEV-EIDKLH-ALRYADSVSM  114
            W+  A+  + D L+  L YAD+V++
Sbjct  35   WIDLAKAGQSDDLNDTLNYADAVAI  59


>Q8CMT8 Dihydroneopterin aldolase [Staphylococcus epidermidis 
(strain ATCC 12228 / FDA PCI 1200)]
Length=121

 Score = 41.2 bits (95),  Expect = 3e-09
 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 0/85 (0%)

Query  7   IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
           II +  +R   + G+   E +  Q  V+++T+      A  S+D+ D +NY  V K++  
Sbjct  4   IIFLNGMRFYGYHGVLAAENDIGQIFVVDITLKVDLSYAGQSDDVKDTVNYGEVYKDVKS  63

Query  67  HVENNRFSLLEKLTQDVLDIAREHH  91
            VE  R  L+E L + +      H+
Sbjct  64  IVEGPRSCLIEHLAERIAKHINSHY  88


>Q5HRN9 Dihydroneopterin aldolase [Staphylococcus epidermidis 
(strain ATCC 35984 / RP62A)]
Length=121

 Score = 41.2 bits (95),  Expect = 3e-09
 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 0/85 (0%)

Query  7   IIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQ  66
           II +  +R   + G+   E +  Q  V+++T+      A  S+D+ D +NY  V K++  
Sbjct  4   IIFLNGMRFYGYHGVLAAENDIGQIFVVDITLKVDLSYAGQSDDVKDTVNYGEVYKDVKS  63

Query  67  HVENNRFSLLEKLTQDVLDIAREHH  91
            VE  R  L+E L + +      H+
Sbjct  64  IVEGPRSCLIEHLAERIAKHINSHY  88


>Q9PJC6 Probable dihydroneopterin aldolase [Chlamydia muridarum 
(strain MoPn / Nigg)]
Length=122

 Score = 40.4 bits (93),  Expect = 6e-09
 Identities = 22/81 (27%), Positives = 48/81 (59%), Gaps = 1/81 (1%)

Query  10  IKNLRLRTFIGIKEEEINNRQDIVINVTIHYPAD-KARTSEDINDALNYRTVTKNIIQHV  68
           + N R+   IG+ E+E  ++Q I+++V++ +  + K  ++++I+D + Y  +   I Q  
Sbjct  6   VTNFRVWVSIGVSEQERYHKQPILVSVSLVFREEPKVCSTDEISDGICYAALVSLIEQTA  65

Query  69  ENNRFSLLEKLTQDVLDIARE  89
            N+  +LLE+L + +L+   E
Sbjct  66  ANHPCALLERLAKVLLEKLEE  86


 Score = 18.1 bits (35),  Expect = 0.58
 Identities = 9/31 (29%), Positives = 14/31 (45%), Gaps = 0/31 (0%)

Query  84   LDIAREHHWVTYAEVEIDKLHALRYADSVSM  114
            LD+     WV+    E ++ H      SVS+
Sbjct  4    LDVTNFRVWVSIGVSEQERYHKQPILVSVSL  34



Lambda      K        H        a         alpha
   0.325    0.136    0.395    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 198621


  Database: a0b71d7853a3026821bee178ab93a7dd.SwissProt.fasta
    Posted date:  May 20, 2024  10:57 AM
  Number of letters in database: 2,725
  Number of sequences in database:  13



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40