BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 58931a5b6de1dcdca797df0fdf42f544.SwissProt.fasta
14 sequences; 5,946 total letters
Query= ACIAD3553
Length=385
Score E
Sequences producing significant alignments: (Bits) Value
P77806 Methionine aminotransferase [Escherichia coli (strain K12)] 358 1e-125
P9WPZ4 Probable N-succinyldiaminopimelate aminotransferase DapC [... 248 3e-82
P9WPZ5 Probable N-succinyldiaminopimelate aminotransferase DapC [... 248 3e-82
Q8BTY1 Kynurenine--oxoglutarate transaminase 1 [Mus musculus] 221 1e-71
Q08415 Kynurenine--oxoglutarate transaminase 1 [Rattus norvegicus] 215 2e-69
Q16773 Kynurenine--oxoglutarate transaminase 1 [Homo sapiens] 209 5e-67
Q54KM6 Kynurenine--oxoglutarate transaminase [Dictyostelium disco... 206 7e-66
Q71RI9 Kynurenine--oxoglutarate transaminase 3 [Mus musculus] 200 4e-63
Q6YP21 Kynurenine--oxoglutarate transaminase 3 [Homo sapiens] 199 5e-63
Q58FK9 Kynurenine--oxoglutarate transaminase 3 [Rattus norvegicus] 199 1e-62
Q7T3E5 Kynurenine--oxoglutarate transaminase 3 [Danio rerio] 195 3e-61
Q17CS8 Kynurenine aminotransferase [Aedes aegypti] 194 7e-61
H3ZPU1 Aromatic-amino-acid aminotransferase 2 [Thermococcus litor... 173 1e-53
O33822 Probable aspartate/prephenate aminotransferase [Thermus aq... 160 6e-49
>P77806 Methionine aminotransferase [Escherichia coli (strain
K12)]
Length=386
Score = 358 bits (920), Expect = 1e-125
Identities = 186/378 (49%), Positives = 243/378 (64%), Gaps = 2/378 (1%)
Query 6 SKLPNQGVTIFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRAGFNQYVSGDGW 65
SKLP G TIF+ M+ALAQ+ AINLSQGFPDF P L E L G NQY G
Sbjct 10 SKLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGV 69
Query 66 LPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYA 125
LRE + Q+ E+ + D +IT+T GAT A++AAI A++ GDEV+ FDPSYDSYA
Sbjct 70 QALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYA 129
Query 126 PAVRVAGGIPVHLALTAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHHLI 185
PA+ ++GGI +AL P FRVDWQ+ ++ RTR++I+NTPHNP+ T+W D+ L
Sbjct 130 PAIALSGGIVKRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALW 189
Query 186 ELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGYCV 245
+ H++ V+SDEVYEH+ F H S L LRER+ V SFGKT+H+TGWK GYCV
Sbjct 190 QAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCV 249
Query 246 ASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFYQAKRDLFNQGLTQS 305
A + R+++QY F NTPAQ+AL+ ++ PEH L FY+ KRD+ L +S
Sbjct 250 APAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALNES 309
Query 306 RFKFQPTHGTYFQTVDYTAIRPDLNDLEMCYFLAEQYGVVAIPLSVFYQQPDPELRLIRF 365
R + P GTYF VDY+A+ L+D+E C +L +++GV AIPLSVF P P +LIR
Sbjct 310 RLEILPCEGTYFLLVDYSAV-STLDDVEFCQWLTQEHGVAAIPLSVFCADPFPH-KLIRL 367
Query 366 CFAKTEQTLKDATQRLSQ 383
CFAK E TL A +RL Q
Sbjct 368 CFAKKESTLLAAAERLRQ 385
>P9WPZ4 Probable N-succinyldiaminopimelate aminotransferase DapC
[Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)]
Length=397
Score = 248 bits (632), Expect = 3e-82
Identities = 145/388 (37%), Positives = 209/388 (54%), Gaps = 13/388 (3%)
Query 6 SKLPNQGVTIFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRAGFNQYVSGDGW 65
S+L T+F+ M+ALA R+ A+NL QGFPD P +++A DA G NQY G G
Sbjct 4 SRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPGPGS 63
Query 66 LPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYA 125
PLR + Q + V DP E+ +T GAT AI AA+ ++ G EV++ +P YDSY+
Sbjct 64 APLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYS 123
Query 126 PAVRVAGGIPVHLALTAPD---FRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWH 182
P V +AG V + L PD F +D ++ + RTR +I+N+PHNPTG + + +
Sbjct 124 PVVAMAGAHRVTVPLV-PDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELA 182
Query 183 HLIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTG 242
+ E+A +L+V++DEVYEHLVFD H F + ER+ + S K F+ TGWK G
Sbjct 183 AIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIG 242
Query 243 YCVASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFYQAKRDLFNQGL 302
+ L+ R QY ++ G P Q A++ + + L + +A+RD GL
Sbjct 243 WACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAAGL 302
Query 303 TQSRFKFQPTHGTYFQTVDYTAIRPDLNDLEMCYFLAEQYGVVAIPLSVF--------YQ 354
T+ F ++GTYF D + D + E C L E+ GV AIP+S F Q
Sbjct 303 TEIGFAVHDSYGTYFLCADPRPLGYD-DSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQ 361
Query 355 QPDPELRLIRFCFAKTEQTLKDATQRLS 382
Q D L+RF F K + TL +A +RLS
Sbjct 362 QADVWNHLVRFTFCKRDDTLDEAIRRLS 389
>P9WPZ5 Probable N-succinyldiaminopimelate aminotransferase DapC
[Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)]
Length=397
Score = 248 bits (632), Expect = 3e-82
Identities = 145/388 (37%), Positives = 209/388 (54%), Gaps = 13/388 (3%)
Query 6 SKLPNQGVTIFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRAGFNQYVSGDGW 65
S+L T+F+ M+ALA R+ A+NL QGFPD P +++A DA G NQY G G
Sbjct 4 SRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPGPGS 63
Query 66 LPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYA 125
PLR + Q + V DP E+ +T GAT AI AA+ ++ G EV++ +P YDSY+
Sbjct 64 APLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYS 123
Query 126 PAVRVAGGIPVHLALTAPD---FRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWH 182
P V +AG V + L PD F +D ++ + RTR +I+N+PHNPTG + + +
Sbjct 124 PVVAMAGAHRVTVPLV-PDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELA 182
Query 183 HLIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTG 242
+ E+A +L+V++DEVYEHLVFD H F + ER+ + S K F+ TGWK G
Sbjct 183 AIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIG 242
Query 243 YCVASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFYQAKRDLFNQGL 302
+ L+ R QY ++ G P Q A++ + + L + +A+RD GL
Sbjct 243 WACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAAGL 302
Query 303 TQSRFKFQPTHGTYFQTVDYTAIRPDLNDLEMCYFLAEQYGVVAIPLSVF--------YQ 354
T+ F ++GTYF D + D + E C L E+ GV AIP+S F Q
Sbjct 303 TEIGFAVHDSYGTYFLCADPRPLGYD-DSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQ 361
Query 355 QPDPELRLIRFCFAKTEQTLKDATQRLS 382
Q D L+RF F K + TL +A +RLS
Sbjct 362 QADVWNHLVRFTFCKRDDTLDEAIRRLS 389
>Q8BTY1 Kynurenine--oxoglutarate transaminase 1 [Mus musculus]
Length=424
Score = 221 bits (563), Expect = 1e-71
Identities = 131/394 (33%), Positives = 211/394 (54%), Gaps = 32/394 (8%)
Query 20 TALAQRLNAINLSQGFPDFATPDALIEALCDATRAGF--NQYVSGDGWLPLREQVVQQFE 77
T L++ + +NL QGFPDF+ PD ++A AT F NQY S G+ PL + + F
Sbjct 22 TRLSKEYDVVNLGQGFPDFSPPDFAVQAFQQATTGNFMLNQYTSAFGYPPLTKILASFFG 81
Query 78 QRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGGIPVH 137
+ +DP+ + +T GA A+F A QA++ GDEV+I +P+++ Y P +AGG PV
Sbjct 82 KLLGQEMDPLKNVLVTVGAYGALFTAFQALVDEGDEVIIIEPAFNCYEPMTMMAGGRPVF 141
Query 138 LAL-----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHHLIE 186
++L ++ D+++D ++ RT+++++NTP+NP G +++ + +
Sbjct 142 VSLRLSPAPKGQLGSSNDWQLDPTELASKFTPRTKILVLNTPNNPLGKVFSKKELELVAA 201
Query 187 LAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGYCVA 246
L ++HD++ SDEVY+ LV+DGH H S + ER+ +GS GK+F TGWK G+ +
Sbjct 202 LCQQHDVLCFSDEVYQWLVYDGHQHISIASLPGMWERTLTIGSAGKSFSATGWKVGWVMG 261
Query 247 SPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFY----QA---KRDLFN 299
+MK R ++Q + F T AQ A++Q ++ +H + S++ QA RD
Sbjct 262 PDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMGLNRDHMI 321
Query 300 QGLTQSRFKFQPTHGTYF---QTVDYTAIRPDL-------NDLEMCYFLAEQYGVVAIPL 349
Q L K G+YF D+ + PDL D ++ + G+ AIP+
Sbjct 322 QSLQSVGLKPLIPQGSYFLIADISDFKSSMPDLPGAMDEPYDTRFAKWMIKNKGLSAIPV 381
Query 350 SVFYQQPDPE--LRLIRFCFAKTEQTLKDATQRL 381
S FY QP + IRFCF K + TL+ +RL
Sbjct 382 STFYSQPHHKDFDHYIRFCFVKDKATLQAMDKRL 415
>Q08415 Kynurenine--oxoglutarate transaminase 1 [Rattus norvegicus]
Length=423
Score = 215 bits (548), Expect = 2e-69
Identities = 126/392 (32%), Positives = 205/392 (52%), Gaps = 32/392 (8%)
Query 22 LAQRLNAINLSQGFPDFATPDALIEALCDATRAGF--NQYVSGDGWLPLREQVVQQFEQR 79
L + + +NL QGFPDF+ PD +A AT F NQY G+ PL + F +
Sbjct 24 LTKEYDVVNLGQGFPDFSPPDFATQAFQQATSGNFMLNQYTRAFGYPPLTNVLASFFGKL 83
Query 80 DQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGGIPVHLA 139
+DP+ + +T GA A+F QA++ GDEV+I +P++D Y P +AGG PV +
Sbjct 84 LGQEMDPLTNVLVTVGAYGALFTRFQALVDEGDEVIIMEPAFDCYEPMTMMAGGCPVFVT 143
Query 140 LT---APDFRV----DWQ----QVQDNINARTRMIIVNTPHNPTGTLWTLDDWHHLIELA 188
L AP ++ DWQ ++ RT+++++NTP+NP G +++ + + L
Sbjct 144 LKPSPAPKGKLGASNDWQLDPAELASKFTPRTKILVLNTPNNPLGKVFSRMELELVANLC 203
Query 189 EKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGYCVASP 248
++HD++ +SDEVY+ LV+DGH H S + +R+ +GS GK+F TGWK G+ +
Sbjct 204 QQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAGKSFSATGWKVGWVMGPD 263
Query 249 MLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFY-------QAKRDLFNQG 301
+MK R ++Q + F T AQ A++Q ++ +H + S++ + RD +
Sbjct 264 NIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMELNRDHMIRS 323
Query 302 LTQSRFKFQPTHGTYFQTVDYTAIR---PDL-------NDLEMCYFLAEQYGVVAIPLSV 351
L K + G+YF D + + PDL D ++ + G+V IP+S
Sbjct 324 LQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAEDEPYDRRFAKWMIKNMGLVGIPVST 383
Query 352 FYQQPDPE--LRLIRFCFAKTEQTLKDATQRL 381
F+ +P + IRFCF K + TL+ +RL
Sbjct 384 FFSRPHQKDFDHYIRFCFVKDKATLQAMDERL 415
>Q16773 Kynurenine--oxoglutarate transaminase 1 [Homo sapiens]
Length=422
Score = 209 bits (532), Expect = 5e-67
Identities = 123/392 (31%), Positives = 205/392 (52%), Gaps = 32/392 (8%)
Query 22 LAQRLNAINLSQGFPDFATPDALIEALCDATRAGF--NQYVSGDGWLPLREQVVQQFEQR 79
LA + +NL QGFPDF PD +EA A F NQY G+ PL + + F +
Sbjct 24 LASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGEL 83
Query 80 DQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGGIPVHLA 139
+DP+ + +T G A+F A QA++ GDEV+I +P +D Y P +AGG PV ++
Sbjct 84 LGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVS 143
Query 140 L-----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHHLIELA 188
L ++ ++++D ++ +RT+ +++NTP+NP G +++ ++ + L
Sbjct 144 LKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLC 203
Query 189 EKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGYCVASP 248
++HD++ ++DEVY+ +V+DGH H S + ER+ +GS GKTF TGWK G+ +
Sbjct 204 QQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPD 263
Query 249 MLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELGSFY-------QAKRDLFNQG 301
+MK R ++Q + F T +Q A+++ ++ ++ S++ Q RD +
Sbjct 264 HIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRS 323
Query 302 LTQSRFKFQPTHGTYFQTVDYTAIR---PDL-------NDLEMCYFLAEQYGVVAIPLSV 351
L K G+YF D + + PDL D ++ + G+VAIP+S+
Sbjct 324 LQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSI 383
Query 352 FYQQPDPEL--RLIRFCFAKTEQTLKDATQRL 381
FY P + IRFCF K E TL+ ++L
Sbjct 384 FYSVPHQKHFDHYIRFCFVKDEATLQAMDEKL 415
Score = 20.0 bits (40), Expect = 1.7
Identities = 6/16 (38%), Positives = 11/16 (69%), Gaps = 0/16 (0%)
Query 181 WHHLIELAEKHDLIVL 196
W ++LA +HD++ L
Sbjct 18 WVEFVKLASEHDVVNL 33
>Q54KM6 Kynurenine--oxoglutarate transaminase [Dictyostelium discoideum]
Length=435
Score = 206 bits (525), Expect = 7e-66
Identities = 126/415 (30%), Positives = 210/415 (51%), Gaps = 39/415 (9%)
Query 5 SSKLPNQGVTIFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRAG-FNQYVSGD 63
S + + G +++ + LA + NA+NL QGFP+F P + +A+ G FNQY
Sbjct 17 SKQTSSFGPSVWLEFSPLAIKYNAVNLGQGFPNFEPPKFVKDAMIKTIEVGGFNQYTRSP 76
Query 64 GWLPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDS 123
G + L + + + L+ + EI + GA+ ++FAAI ++++ GDEV++ +P +D
Sbjct 77 GHIRLVKALSSVYSPYFGRELNAMTEIMVGVGASESLFAAISSIVNEGDEVILIEPFFDI 136
Query 124 YAPAVRVAGGIPVHLAL---------------TAPDFRVDWQQVQDNINARTRMIIVNTP 168
Y + +AGGIP + L ++ ++++ +++ +T++II+N P
Sbjct 137 YIGPILMAGGIPKFVTLKEEESSQAGSSDKKRSSKHWKINKEELAAAFTDKTKLIILNNP 196
Query 169 HNPTGTLWTLDDWHHLIELAEKH--DLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFV 226
HNP G +++ ++ + ++ KH + V+SDEVYE + FDG H+ + ER+
Sbjct 197 HNPVGKVYSKEELQEIADVVAKHGPNTTVISDEVYEWMTFDGEEHHRFATLPGMWERTIT 256
Query 227 VGSFGKTFHVTGWKTGYCVASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQH--PEHI 284
+GS GKTF +TGWK G+C+ ++ +QY F TP Q A++ ++Q ++
Sbjct 257 IGSAGKTFSITGWKVGWCIGPSNIIGAIANTHQYVPFSVPTPTQEAVAIALEQPNIKDYF 316
Query 285 QELGSFYQAKRDLFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPD---------------L 329
+EL + YQ KRD LTQ+ GTYF D ++I L
Sbjct 317 KELATMYQNKRDTLLNSLTQAGLDPVIPQGTYFIMGDTSSIHLQGDQGKDTSITGMGLHL 376
Query 330 NDLEMCYFLAEQYGVVAIPLSVFY---QQPDPELRLIRFCFAKTEQTLKDATQRL 381
D + +L +YGV IP S FY Q PE +RF F K + TL+ A L
Sbjct 377 RDWNIARYLTTEYGVTTIPPSAFYCDDHQKIPE-NFVRFTFCKDDLTLQKAHDNL 430
>Q71RI9 Kynurenine--oxoglutarate transaminase 3 [Mus musculus]
Length=455
Score = 200 bits (508), Expect = 4e-63
Identities = 129/394 (33%), Positives = 201/394 (51%), Gaps = 30/394 (8%)
Query 15 IFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRA-GFNQYVSGDGWLPLREQVV 73
++ T LA + +NL QGFPD + P + E L A NQY G G L + +
Sbjct 53 VWVEFTKLAADPSVVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYTRGFGHPALVKALS 112
Query 74 QQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGG 133
+ + Q ++DP EI + GA ++F +IQ ++ GDEV+I P YD Y P VR+AG
Sbjct 113 CLYGKIYQRQIDPNEEILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFYDCYEPMVRMAGA 172
Query 134 IPVHLAL----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHH 183
+PV + L T+ D+ D ++++ +++T+ II+NTPHNP G ++T +
Sbjct 173 VPVFIPLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQELQV 232
Query 184 LIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGY 243
+ +L KHD + +SDEVYE LV+ GH H + ER+ +GS GKTF VTGWK G+
Sbjct 233 IADLCVKHDTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITIGSAGKTFSVTGWKLGW 292
Query 244 CVASPMLMKLFRQIYQYANFCGNTPAQVALSQYM------QQHPE-HIQELGSFYQAKRD 296
+ L+K + + Q + + TP Q AL++ PE + L + KRD
Sbjct 293 SIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKELEVKRD 352
Query 297 LFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPDLNDL--------EMCYFLAEQYGVVAIP 348
+ L K G YF D +++ DL+D+ + ++ + + AIP
Sbjct 353 RMVRLLNSVGLKPIVPDGGYFIIADVSSLGADLSDMNSDEPYDYKFVKWMTKHKKLTAIP 412
Query 349 LSVF---YQQPDPELRLIRFCFAKTEQTLKDATQ 379
+S F +P E +L+RFCF K + TL A +
Sbjct 413 VSAFCDSKSKPHFE-KLVRFCFIKKDSTLDAAEE 445
>Q6YP21 Kynurenine--oxoglutarate transaminase 3 [Homo sapiens]
Length=454
Score = 199 bits (507), Expect = 5e-63
Identities = 129/393 (33%), Positives = 198/393 (50%), Gaps = 28/393 (7%)
Query 15 IFSTMTALAQRLNAINLSQGFPDFATPDALIEALCD-ATRAGFNQYVSGDGWLPLREQVV 73
++ T LA + +NL QGFPD + P + E L A NQY G G L + +
Sbjct 52 VWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALS 111
Query 74 QQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGG 133
+E+ Q ++D EI +T GA ++F IQA+I GDEV++ P YD Y P VR+AG
Sbjct 112 YLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGA 171
Query 134 IPVHLAL----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHH 183
PV + L ++ D+ +D Q+++ N++T+ II+NTPHNP G ++ ++
Sbjct 172 TPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQV 231
Query 184 LIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGY 243
+ +L K+D + +SDEVYE LV+ G+ H F + ER+ +GS GKTF VTGWK G+
Sbjct 232 IADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGW 291
Query 244 CVASPMLMKLFRQIYQYANFCGNTPAQVALSQYM------QQHPE-HIQELGSFYQAKRD 296
+ L+K + + Q + TP Q AL+Q PE + L + KRD
Sbjct 292 SIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRD 351
Query 297 LFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPDLNDL--------EMCYFLAEQYGVVAIP 348
+ L K G YF D + + PDL+D+ + ++ + + AIP
Sbjct 352 RMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIP 411
Query 349 LSVFYQQPDPEL--RLIRFCFAKTEQTLKDATQ 379
+S F + +RFCF K + TL A +
Sbjct 412 VSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEE 444
>Q58FK9 Kynurenine--oxoglutarate transaminase 3 [Rattus norvegicus]
Length=454
Score = 199 bits (505), Expect = 1e-62
Identities = 128/393 (33%), Positives = 199/393 (51%), Gaps = 28/393 (7%)
Query 15 IFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRA-GFNQYVSGDGWLPLREQVV 73
++ T LA + +NL QGFPD P + E L A NQY G G L + +
Sbjct 52 VWVEFTKLAADPSVVNLGQGFPDITLPSYVQEELSKAAFIDNLNQYTRGFGHPSLVKALS 111
Query 74 QQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGG 133
+ + Q ++DP EI +T G ++F AIQ ++ GDEV+I P YD Y P V++AG
Sbjct 112 CLYGKIYQKQIDPNEEILVTVGGYGSLFNAIQGLVDPGDEVIIMVPFYDCYEPMVKMAGA 171
Query 134 IPVHLAL----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHH 183
+PV + L T+ D+ + Q+++ +++T+ II+NTPHNP G ++T ++
Sbjct 172 VPVFIPLRSKRTDGMKWTSSDWTFNPQELESKFSSKTKAIILNTPHNPIGKVYTREELQV 231
Query 184 LIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGY 243
+ +L KHD + +SDEVYE LV+ GH H + +R+ +GS GKTF VTGWK G+
Sbjct 232 IADLCIKHDTLCISDEVYEWLVYTGHKHIKVASLPGMWDRTLTIGSAGKTFSVTGWKLGW 291
Query 244 CVASPMLMKLFRQIYQYANFCGNTPAQVALSQYM------QQHPE-HIQELGSFYQAKRD 296
+ L+K R + Q + + TP Q AL++ PE + L + KRD
Sbjct 292 SIGPGHLIKHLRTVQQTSVYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKELEVKRD 351
Query 297 LFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPDLNDL--------EMCYFLAEQYGVVAIP 348
L K G YF D +++ DL+D+ + ++ + + AIP
Sbjct 352 RMACLLNSVGLKPIIPDGGYFIIADVSSLGVDLSDVKSDEPYDYKFVKWMTKNKKLSAIP 411
Query 349 LSVFY-QQPDPEL-RLIRFCFAKTEQTLKDATQ 379
+S F + P +L+RFCF K + TL A +
Sbjct 412 VSAFCDSESKPHFEKLVRFCFIKKDSTLDAAEE 444
>Q7T3E5 Kynurenine--oxoglutarate transaminase 3 [Danio rerio]
Length=450
Score = 195 bits (495), Expect = 3e-61
Identities = 121/391 (31%), Positives = 196/391 (50%), Gaps = 28/391 (7%)
Query 15 IFSTMTALAQRLNAINLSQGFPDFATPDALIEALCDATRAG-FNQYVSGDGWLPLREQVV 73
++ T++A + +NL QG+PD P + E L A NQY G G L + +
Sbjct 50 VWVAFTSVAADPSIVNLGQGYPDIPPPSYVKEGLAQAAMVDRLNQYTRGFGHPTLVKALS 109
Query 74 QQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGG 133
+ + + +LDP EI +T G ++F+ +QA++ GDEV+I +P +D Y P V++AG
Sbjct 110 KVYGKVYDRQLDPFKEILVTVGGYGSLFSTMQALVEEGDEVIIIEPFFDCYVPMVKMAGA 169
Query 134 IPVHLAL----------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHH 183
PV + L ++ D+ +D +++ N++T+ IIVNTP+NP G +++ +
Sbjct 170 KPVLIPLRLKSTATTGISSADWVLDQEELASKFNSKTKAIIVNTPNNPIGKIFSRSELQA 229
Query 184 LIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGY 243
+ +L KHD + SDEVYE L++ GH H + +R+ VGS GKTF VTGWK G+
Sbjct 230 IADLCIKHDTLCFSDEVYEWLIYKGHEHVKIATLPGMWDRTITVGSAGKTFSVTGWKLGW 289
Query 244 CVASPMLMKLFRQIYQYANFCGNTPAQVALS-------QYMQQHPEHIQELGSFYQAKRD 296
+ L++ + + Q + + TP Q A+ + M Q + L + KRD
Sbjct 290 SIGPEHLIRHLQTVMQNSLYTCPTPLQEAVGRGLLRDFELMGQPDCYFSALALELEGKRD 349
Query 297 LFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPDLN--------DLEMCYFLAEQYGVVAIP 348
L Q+ G YF VD TA+ DL D + ++ ++ + AIP
Sbjct 350 RMAAMLAQTGMTPVVPEGGYFMIVDVTALNQDLTHMGDDEPYDYKFVKWMIKEKKLAAIP 409
Query 349 LSVFYQQPDPEL--RLIRFCFAKTEQTLKDA 377
++ F + + + IR CF K E TL A
Sbjct 410 VTAFVGEDSVKQFEKYIRLCFIKQESTLDAA 440
>Q17CS8 Kynurenine aminotransferase [Aedes aegypti]
Length=477
Score = 194 bits (494), Expect = 7e-61
Identities = 120/390 (31%), Positives = 197/390 (51%), Gaps = 30/390 (8%)
Query 22 LAQRLNAINLSQGFPDFATPDALIEALCDATRAG---FNQYVSGDGWLPLREQVVQQFEQ 78
LA + +NL QGFPD+ P ++AL A + NQY G G L + + + + Q
Sbjct 81 LAAQYKPLNLGQGFPDYHAPKYALDALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQ 140
Query 79 RDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYDSYAPAVRVAGGIPVHL 138
++P+ E+ +T GA A++A IQ + GDEV+I +P +D Y P V+ AGGIP +
Sbjct 141 LVDRTINPMTEVLVTVGAYEALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFI 200
Query 139 AL---------TAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDWHHLIELAE 189
L ++ D+ +D +++ N +T+MII+NTPHNP G + + + L +
Sbjct 201 PLKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGKVMDRAELEVVANLCK 260
Query 190 KHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKTGYCVASPM 249
K +++ +SDEVYEH+VF+ H + ER+ +GS GKTF +TGWK G+
Sbjct 261 KWNVLCVSDEVYEHMVFEPFEHIRICTLPGMWERTITIGSAGKTFSLTGWKIGWAYGPEA 320
Query 250 LMKLFRQIYQYANFCGNTPAQVALSQYMQ------QHPE-HIQELGSFYQAKRDLFNQGL 302
L+K + ++Q + TP Q A++ + + PE + + AKRD L
Sbjct 321 LLKNLQMVHQNCVYTCATPIQEAIAVGFETELKRLKSPECYFNSISGELMAKRDYMASFL 380
Query 303 TQSRFKFQPTHGTYFQTVDYTAI--RPDL-------NDLEMCYFLAEQYGVVAIPLSVFY 353
+ G YF D++++ + DL D ++ + G+ IP S FY
Sbjct 381 AEVGMNPTVPQGGYFMVADWSSLDSKVDLTQETDARKDYRFTKWMTKSVGLQGIPPSAFY 440
Query 354 QQPDPEL--RLIRFCFAKTEQTLKDATQRL 381
+P+ L +R+CF K ++ L+ A + L
Sbjct 441 SEPNKHLGEDFVRYCFFKKDENLQKAAEIL 470
>H3ZPU1 Aromatic-amino-acid aminotransferase 2 [Thermococcus litoralis
(strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)]
Length=389
Score = 173 bits (439), Expect = 1e-53
Identities = 114/386 (30%), Positives = 193/386 (50%), Gaps = 13/386 (3%)
Query 4 LSSKLPNQGVTIFSTMTALAQRLNAI-NLSQGFPDFATPDALIEALCDATRAGFNQYVSG 62
LS +L + + LAQ + I +L G PDF TP+ + E +A G Y
Sbjct 3 LSDRLEMVNPSEIRKLFDLAQGIEGIISLGIGEPDFDTPEHIKEYAKEALDKGLTHYSPN 62
Query 63 DGWLPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPSYD 122
G L LRE V ++F++ + + DP +I IT G I + + +EV+I P +
Sbjct 63 IGILELREAVAEKFKKHNGIDADPKTQIMITVGTNQQILMGLATFLKDNEEVLIPSPMFV 122
Query 123 SYAPAVRVAGGIPVHL-ALTAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLDDW 181
SYAPAV +AGG PV + +FR+ +++ + +TR +I+NTP+NPTG + T D
Sbjct 123 SYAPAVILAGGKPVEVPTYEENEFRLSVDELEKYVTPKTRALIINTPNNPTGAVLTKKDL 182
Query 182 HHLIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGWKT 241
+ + A +HDL++LSDEVYE+ V+DG +YS + ER+ + F KTF +TGW+
Sbjct 183 EEIADFAVEHDLMILSDEVYEYFVYDGVKNYSIASLDGMFERTITMNGFSKTFAMTGWRL 242
Query 242 GYCVASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHP--EHIQELGSFYQAKRDLFN 299
G+ A +++ + Y C T Q A ++ ++ + ++E+ Y+ +R+L
Sbjct 243 GFLAAPEWVVEKMVRFQMYNATCPVTFIQYAAAKALRDERSWQAVEEMRREYERRRNLVW 302
Query 300 QGLTQSRFKFQPTHGTY--FQTVDYTAIRPDLNDLEMCYFLAEQYGVVAIPLSVFYQQPD 357
+ L + G + F + T L+ E + ++ VV +P S F Q +
Sbjct 303 KRLNEMGLPTVKPKGAFYIFPRIKDTG----LSSKEFSELMIKEAKVVVVPGSAFGQAGE 358
Query 358 PELRLIRFCFAKTEQTLKDATQRLSQ 383
+R +A + L++A R+ +
Sbjct 359 ---GYVRISYATAYEKLEEAMDRMEK 381
>O33822 Probable aspartate/prephenate aminotransferase [Thermus
aquaticus]
Length=383
Score = 160 bits (406), Expect = 6e-49
Identities = 111/387 (29%), Positives = 190/387 (49%), Gaps = 17/387 (4%)
Query 2 QPLSSKLPNQGVTIFSTMTALAQR-LNAINLSQGFPDFATPDALIEALCDATRAGFNQYV 60
Q + S P+ V + + L ++ ++ + L+ G PDF TP+ + EA A G +Y
Sbjct 6 QRVKSMKPSATVAVNARALELRRKGVDLVALTAGEPDFDTPEHVKEAGRRALAQGKTKYA 65
Query 61 SGDGWLPLREQVVQQFEQRDQVRLDPVHEITITPGATIAIFAAIQAVIHTGDEVVIFDPS 120
G LRE V ++F + + + + P E +T G A+F QA++ GDEV++ P
Sbjct 66 PPAGIPELREAVAEKFRRENGLEVTP-EETIVTVGGKQALFNLFQAILDPGDEVIVLAPY 124
Query 121 YDSYAPAVRVAGGIPVHL-ALTAPDFRVDWQQVQDNINARTRMIIVNTPHNPTGTLWTLD 179
+ SY VR AGG+PV + L F D ++V+ I RT+ ++VN+P+NPTG ++ +
Sbjct 125 WVSYPEMVRFAGGVPVEVPTLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGVVYPEE 184
Query 180 DWHHLIELAEKHDLIVLSDEVYEHLVFDGHHHYSALHFSTLRERSFVVGSFGKTFHVTGW 239
L E+A +HD ++SDE+YEHL+++G H + E + V K F +TGW
Sbjct 185 VLRALAEMALQHDFYLVSDEIYEHLIYEGAHFSPG---TLAPEHTITVNGAAKAFAMTGW 241
Query 240 KTGYCVASPMLMKLFRQIYQYANFCGNTPAQVALSQYMQQHPEHIQELG---SFYQAKRD 296
+ GY ++K + + +T AQ A + + + + Y+ +RD
Sbjct 242 RIGYACGPKAVIKAMADVSSQSTTSPDTIAQWATLEALTNREASMAFIAMAREAYRKRRD 301
Query 297 LFNQGLTQSRFKFQPTHGTYFQTVDYTAIRPDLNDLEMCYFLAEQYGVVAIPLSVFYQQP 356
L +GL++ + G ++ +D + P N++E L GV +P + F
Sbjct 302 LLLEGLSRIGLEAVRPSGAFYVLMDTSPFAP--NEVEAAERLL-MAGVAVVPGTEF---- 354
Query 357 DPELRLIRFCFAKTEQTLKDATQRLSQ 383
+R +A E+ LK A +R +Q
Sbjct 355 -AAFGHVRLSYATGEENLKKALERFAQ 380
Lambda K H a alpha
0.325 0.138 0.429 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1767360
Database: 58931a5b6de1dcdca797df0fdf42f544.SwissProt.fasta
Posted date: May 30, 2024 8:15 AM
Number of letters in database: 5,946
Number of sequences in database: 14
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
