BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 56f402ae352d0b11d4825f77b16e23e5.SwissProt.fasta
20 sequences; 9,841 total letters
Query= ACIAD3364
Length=469
Score E
Sequences producing significant alignments: (Bits) Value
P11880 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 315 2e-106
P45061 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 296 4e-99
P57315 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 264 2e-86
Q89AQ1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 254 2e-82
O33804 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 220 8e-70
P96613 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 205 7e-64
P45450 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 202 1e-62
P9WJL1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 186 3e-56
P0A5L5 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 186 3e-56
P9WJL0 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 182 5e-55
O83401 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase... 174 4e-52
Q03523 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopime... 117 1e-31
Q819Q0 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopime... 111 1e-29
O86491 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase... 99.8 1e-25
Q2FZP6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase... 99.8 1e-25
Q9WY79 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligas... 87.8 1e-21
Q52953 UDP-N-acetylmuramoylalanine--D-glutamate ligase [Rhizobium... 78.6 1e-18
P22188 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopime... 75.1 2e-17
Q9HW02 UDP-N-acetylmuramate--L-alanine ligase [Pseudomonas aerugi... 71.2 3e-16
F4I3P9 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopime... 68.2 4e-15
>P11880 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Escherichia coli (strain K12)]
Length=452
Score = 315 bits (808), Expect = 2e-106
Identities = 186/435 (43%), Positives = 259/435 (60%), Gaps = 13/435 (3%)
Query 36 TIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQLIVSD 95
T+ + TD+R G F+ALKGERFDAHDF Q G +V +PLD+D+ QLIV D
Sbjct 23 TLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKD 82
Query 96 TRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDLGV 155
TRLA G L A+ RQQ P +V+ALTGSSGKT+ KEM +ILS+ TL T GNLNND+GV
Sbjct 83 TRLAFGELAAWVRQQVPA-RVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGV 141
Query 156 PMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGICRA 215
PM LL L PE+ YAV+ELGA+HQGEI +T L +P A + N+ AHL FG G+ +A
Sbjct 142 PMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKA 201
Query 216 KSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSF---GQDGEIYATSVVLHAQSSE 272
K EI+ + +G AI+ AD++ + I ++K+ F + + AT++ + + +E
Sbjct 202 KGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFSPNAANSDFTATNIHVTSHGTE 261
Query 273 FDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNFIQ 332
F L TP G + LP G HN+ NALAA A ++++G L+ I GL+ + GRL IQ
Sbjct 262 FTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQ 321
Query 333 HG-HHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTGDIGELGDASMLEHTQLGHDLAN 391
+ L +DD+YNAN GSM AA VLA+ G +V+V GD+ ELG S H Q+G
Sbjct 322 LAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGDMAELGAESEACHVQVGEAAKA 381
Query 392 EQLDYIVAVGEFAGAMQQGAASSDHPEKLKAFTTQAQALPFLIELIQQHQPQSMSFLFKG 451
+D +++VG+ + A+ + +H A T+ L LI + Q ++ L KG
Sbjct 382 AGIDRVLSVGKQSHAISTASGVGEHFADKTALITR---LKLLIA-----EQQVITILVKG 433
Query 452 SRYTHMETLMADLME 466
SR ME ++ L E
Sbjct 434 SRSAAMEEVVRALQE 448
>P45061 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Haemophilus influenzae (strain ATCC 51907 / DSM 11121
/ KW20 / Rd)]
Length=457
Score = 296 bits (759), Expect = 4e-99
Identities = 177/441 (40%), Positives = 262/441 (59%), Gaps = 19/441 (4%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQP-LDVDIFQLIVSD 95
+++I TD+R + + F ALKGE+FDAH ++ Q V QG +V+Q + + QL+V D
Sbjct 25 VEKINTDTRKSVSNSLFFALKGEKFDAHQYLDQAVSQGALALVVQQENSSISVPQLVVKD 84
Query 96 TRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAP----TLVTRGNLNN 151
TR+ALG L + R++ + +A+TGSSGKTT KEM SIL A L T GN NN
Sbjct 85 TRIALGELAKWLREKINP-RTVAMTGSSGKTTVKEMTASILQHTAADSEAVLFTNGNFNN 143
Query 152 DLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDG 211
D+GVP+ LL L +H++AV+ELGA+HQ EI+YT+KLVQP+ A I NI AHL FG G
Sbjct 144 DIGVPLTLLRLTEKHRFAVIELGANHQNEINYTTKLVQPNAALINNIAPAHLEGFGSLAG 203
Query 212 ICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFGQDGEIYATSVVLH-AQS 270
+ +AK EIY+ + +G AI+ A+ + D ++ I + F +G+ Y+ + H +Q
Sbjct 204 VVQAKGEIYRGLTKNGVAIINAEHNHLDIWQKEISNHAIQYF--NGKDYSAKNIHHTSQG 261
Query 271 SEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNF 330
S F L +PQG+ ++LP+ GEHNV+NALAATA A+ +G L ++ GL KGRL
Sbjct 262 STFTLISPQGEIEITLPYLGEHNVKNALAATALAMNVGATLTDVKAGLEQRSQVKGRLFP 321
Query 331 IQ-HGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTGDIGELGDASMLEHTQLGHDL 389
IQ + L +DDTYNAN S+ AA VL +++ GD+ ELG+ S+ H ++G +
Sbjct 322 IQVTPNLLLLDDTYNANKDSLCAAIDVLKGYDAFRILCVGDMKELGENSLAIHREVGQYI 381
Query 390 ANEQLDYIVAVGEFAGAMQQGAASSDHPEKLKAFTTQAQALPFLIELI--QQHQPQSMSF 447
LD + + G + + + + K FT + + + FL+ LI Q Q + +
Sbjct 382 NLVNLDLVCSYGNESAVISEAVSG-------KHFTDKTEMVDFLVPLIENQLQQNKKVVV 434
Query 448 LFKGSRYTHMETLMADLMEKL 468
L KGSR ME ++ L +K+
Sbjct 435 LGKGSRSMKMEDVIYSLKDKI 455
>P57315 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Buchnera aphidicola subsp. Acyrthosiphon pisum (strain
APS)]
Length=455
Score = 264 bits (674), Expect = 2e-86
Identities = 154/436 (35%), Positives = 250/436 (57%), Gaps = 14/436 (3%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQLIVSDT 96
I I+ D++ G F+AL G +FDAH F+ +++ C + ++ + + +IV +T
Sbjct 24 INEIVIDTKKIIPGCLFIALIGRKFDAHIFIHDALKKKCAAFVTQKNIKPHVPYIIVENT 83
Query 97 RLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDLGVP 156
+ALG + + R++ K +++A+TGS GKT+ KEM SIL + T+ T NLNN++GVP
Sbjct 84 SIALGQIAGWVRKK-TKAKILAITGSCGKTSVKEMTASILRKNGNTISTIDNLNNNIGVP 142
Query 157 MMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGICRAK 216
M LL+L+ EH+Y V+ELGAS GEI YTS + QP + I NI AHL F G+ +AK
Sbjct 143 MTLLQLKQEHKYGVIELGASKPGEIAYTSNISQPDIILINNIHCAHLQGFKSLLGVSKAK 202
Query 217 SEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFG----QDGEIYATSVVLHAQSSE 272
SEI+ + + T I+ D Q K+ I+ +L F + + +++ +H +
Sbjct 203 SEIFSGLKPNSTVIINLDSHHFSQWKKDIKNSNILFFSIKKKKYSNFFCSNIKIHIHGTS 262
Query 273 FDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRL-NFI 331
F +HTP G+ ++SLPF G N+ NALAA+AF+ A+ I L I GL RL + I
Sbjct 263 FTMHTPCGKINISLPFLGYQNISNALAASAFSFALKIPLKKIKIGLLDTPIVSKRLESII 322
Query 332 QHGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTGDIGELGDASMLEHTQLGHDLAN 391
+ + IDDTYN+N SM +A VL + G K++VTGD+ ELG+ SM+ H +G+ +
Sbjct 323 LEPNKILIDDTYNSNVSSMISAIKVLERMPGYKILVTGDMAELGENSMMYHQMIGNTANS 382
Query 392 EQLDYIVAVGEFAGAMQQGAASSDHPEKLKAFTTQAQALPFLIELIQQHQPQSMSFLFKG 451
++ I ++G+ + + + + H F + + +L + + + ++ L KG
Sbjct 383 SAINKIFSIGDMSSEITKIFNNGKH------FLNKKKLSEYLKNVFL--KKKKITILVKG 434
Query 452 SRYTHMETLMADLMEK 467
SR T ME ++ DL+++
Sbjct 435 SRSTKMEKVVEDLIKE 450
>Q89AQ1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Buchnera aphidicola subsp. Baizongia pistaciae (strain
Bp)]
Length=460
Score = 254 bits (648), Expect = 2e-82
Identities = 145/387 (37%), Positives = 232/387 (60%), Gaps = 8/387 (2%)
Query 36 TIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQ---PLDVDIFQLI 92
+I I TD+R F+AL G+ FDAH FV + + +G ++E+ P +V I Q+I
Sbjct 29 SIHSITTDTRKITPKCLFIALIGKNFDAHMFVNEAISKGAAALLLEKQCYPKNV-IPQII 87
Query 93 VSDTRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNND 152
V +T +ALG + ++ R Q VIA+TGSSGKT+ KEM SIL T+ T NLNN+
Sbjct 88 VQNTTIALGKIASWIRDQ-TNATVIAITGSSGKTSVKEMTSSILKNCGNTISTFQNLNNN 146
Query 153 LGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGI 212
+GVP+ LL L H+YA++ELGA++ +I+YT+K+ +P++A I NI +HL F G+
Sbjct 147 IGVPLTLLNLNKSHKYAILELGANYPKDIEYTTKITKPNIALINNIYHSHLAGFKSLFGV 206
Query 213 CRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFG--QDGEIYATSVVLHAQS 270
+AK EI+ + +G AI D ++ + K+ + TQK+++F ++ I+A+++ Q
Sbjct 207 AQAKQEIFLGLRKNGIAIYNKDSNYWSKWKKNLLTQKIINFSIKKNSTIFASNITTSNQG 266
Query 271 SEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNF 330
S+F +H+P G+ +++LP G HN+ NALAA A++I I L I GLS+ K RL
Sbjct 267 SKFKIHSPNGEIYVTLPLLGYHNISNALAAATIAISINIPLEIIKIGLSSLPILKNRLQI 326
Query 331 IQ-HGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTGDIGELGDASMLEHTQLGHDL 389
I+ + + I+DTYNAN SM A +L +G K+ V GD+ ELG +L H +G+ +
Sbjct 327 IRLNKYKTIINDTYNANTASMIVAIKILENISGYKLFVAGDMLELGKNDVLYHKIIGNTI 386
Query 390 ANEQLDYIVAVGEFAGAMQQGAASSDH 416
N ++ + ++G+ + + + H
Sbjct 387 YNSNINEVFSIGKLSKEISIASKKGHH 413
>O33804 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Streptomyces toyocaensis]
Length=446
Score = 220 bits (561), Expect = 8e-70
Identities = 144/376 (38%), Positives = 206/376 (55%), Gaps = 12/376 (3%)
Query 43 DSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQLIVSDTRLALGA 102
DSR AE G F+A GE D HD+ + + G + +P + ++V D R AL
Sbjct 31 DSRQAEPGGLFVAFAGEHADGHDYAERAGRAGAVAVLGSRPTSLPT--VVVEDVRTALQT 88
Query 103 LGAYRRQQYPK-LQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLE 161
L A+ + L V+ +TGS GKT TK++L ++LS PT+ T G+LNN+LGVP+ +L
Sbjct 89 LAAHVVARLRDGLTVVGVTGSQGKTGTKDLLAAVLSGAGPTVATTGSLNNELGVPLTMLR 148
Query 162 LRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGICRAKSEIYQ 221
+ ++ V+E+GA H+G+I + LV P +A +LN+G AHLGEFG R I RAK E+ Q
Sbjct 149 AQAATRFLVLEMGARHEGDIAELTGLVAPDIAVVLNVGVAHLGEFGSRAAIARAKGELVQ 208
Query 222 HIAVDGTAILPADDDFTDQIKQAIQTQKMLSFGQ--DGEIYATSVVL-HAQSSEFDLHTP 278
+ GTA+L ADD + + +L+FG+ ++ VVL L T
Sbjct 209 GLVPGGTAVLNADDPRVASM-SVLTDGPVLTFGRTDPADVQVLDVVLDRLGRPSCTLRTV 267
Query 279 QGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNF--IQHGHH 336
A L+LP G H NA AA A ALA G+ L+ L+ A + R+ + G
Sbjct 268 DTSARLALPLVGAHQALNASAAAAAALAAGVPLDLATTALTTASLSPWRMELRDLACGAT 327
Query 337 LFIDDTYNANPGSMRAAAGVL-AQQTGIKVMVTGDIGELGDASMLEHTQLGHDLANEQLD 395
L ++D+YNANP S RAA L A + G ++ V G++ ELGD S EH +G A + D
Sbjct 328 L-LNDSYNANPDSTRAALDALSAIEGGRRIAVLGEMLELGDGSEAEHRAVG-AYAAARAD 385
Query 396 YIVAVGEFAGAMQQGA 411
+VAVGE A + GA
Sbjct 386 VVVAVGEAARPLADGA 401
>P96613 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Bacillus subtilis (strain 168)]
Length=457
Score = 205 bits (521), Expect = 7e-64
Identities = 144/455 (32%), Positives = 229/455 (50%), Gaps = 17/455 (4%)
Query 19 LQQATQGYWHNNRQPEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVA 78
+ + +G N + + I + TD+R E F+ LKGERFD H FV Q + G
Sbjct 9 IAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHSFVEQAFEAGVAAV 68
Query 79 IVEQPLD---VDIFQLIVSDTRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSI 135
+ ++ + + ++V DT AL L Q+ +VI +TGS+GKTTTK+M+ ++
Sbjct 69 LWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQELGT-RVIGVTGSNGKTTTKDMIHAV 127
Query 136 LSRLAPTLVTRGNLNNDLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGI 195
L T GN NN +G+P+ +L + + AV+E+G S +GEID S+L P A I
Sbjct 128 LGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAAVI 187
Query 196 LNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFGQ 255
NIG +H+ + G R+GI AK EI + DG I D+ Q + QT K G
Sbjct 188 TNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEPLL-QNAYSCQT-KTYGTGT 245
Query 256 DGEIYATSVVLHAQSSEFDLHTPQG-QAHLSLPFAGEHNVQNALAATAFALAIGIDLNNI 314
+ V +QS E T +G + +P G+HNV NA+AA A GI +
Sbjct 246 HNDYQLQDV---SQSEEGTHFTIKGIENTFFIPILGKHNVMNAMAAIAAGAYFGIAPEDA 302
Query 315 VQGLSAAQGAKGRLNFIQHGHHL-FIDDTYNANPGSMRAAAGVLAQQTGI--KVMVTGDI 371
+GLS + RL I+ L I+D YNA+P SM+AA + G K++V GD+
Sbjct 303 AKGLSGLKVTGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYGKKMLVLGDM 362
Query 372 GELGDASMLEHTQLGHDLANEQLDYIVAVGEFAGAMQQGAASSDHPEKLKAFTTQAQALP 431
ELGD H + G ++ +++D + G+ + +GA +++ +T +
Sbjct 363 LELGDLEETFHKECGAVISPDKIDRVFTYGKLGAFIAEGALKHFEKDRVSHYTEKKD--- 419
Query 432 FLIELIQQHQPQSMSFLFKGSRYTHMETLMADLME 466
L++ ++++ + LFK SR +E ++ DL+E
Sbjct 420 -LLQAVKENASKGDLILFKASRGMKLEEIVKDLIE 453
>P45450 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Synechocystis sp. (strain PCC 6803 / Kazusa)]
Length=454
Score = 202 bits (513), Expect = 1e-62
Identities = 137/410 (33%), Positives = 212/410 (52%), Gaps = 33/410 (8%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLD---VDIFQLIV 93
I I TD+R +GD FLAL+GE FD H F+ Q + G + ++P++ + Q +V
Sbjct 30 INNICTDTRSLVSGDLFLALRGESFDGHSFIPQALTAGAIAVVTDRPVEGLGETVAQFLV 89
Query 94 SDTRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDL 153
DT +A + A RQ++ + +I +TGS GKTTTKE++ ++LS+ TR N NN++
Sbjct 90 EDTLVAYQHIAAGWRQRFT-IPIIGVTGSVGKTTTKELIAAVLSQFGNVHKTRANYNNEI 148
Query 154 GVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGIC 213
GVP LLEL P+H +A++E+ +G+I + + +P + I N+GTAH+G G I
Sbjct 149 GVPKTLLELSPDHDFAIVEMAMRGRGQIALLADIAKPTIGLITNVGTAHIGLLGSELAIA 208
Query 214 RAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFG-QDGEIYAT----SVVLHA 268
AK E+ H + TAIL D+ + Q K +++G + G+++ T +++L
Sbjct 209 EAKCELLAHQPPESTAILNRDNALLMETAQRFWQGKTITYGLEGGDVHGTVDGENLILDG 268
Query 269 QSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRL 328
S L LP AG HN N LAA A A +G+D + GL+ + KGR
Sbjct 269 VS-------------LPLPLAGVHNASNYLAAIALAQCLGLDWQQLQSGLT-VELPKGRA 314
Query 329 NFIQHGHH-LFIDDTYNANPGSMRAAAGVLAQQTG-IKVMVTGDIGELGDASMLEHTQLG 386
Q G + +D+TYN SM A+ +LA G ++ V G + ELGD H ++G
Sbjct 315 RRYQWGQDVVLLDETYNDGLESMLASLDLLANTPGKRRLAVLGAMKELGDYGPTFHQRVG 374
Query 387 HDLANEQLD--YIVAVGEFAGAMQQGA------ASSDHPEKLKAFTTQAQ 428
+ LD +++A A+ GA + SD P + A T Q
Sbjct 375 AKVKALGLDGLFLLANDPNTDAIAAGANGVETQSFSDGPSLVAALKTTLQ 424
>P9WJL1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)]
Length=510
Score = 186 bits (472), Expect = 3e-56
Identities = 136/430 (32%), Positives = 202/430 (47%), Gaps = 46/430 (11%)
Query 30 NRQPEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVD-I 88
+R+ GT++ DSR G FLAL G R D HD A V G V + +P+ V I
Sbjct 27 HRRVTGTVE---FDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAI 83
Query 89 FQLIVSDTRLALGAL-------GAYRRQQYPK-------------LQVIALTGSSGKTTT 128
V+ + G L GA K L +I +TGSSGKT+T
Sbjct 84 VVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTST 143
Query 129 KEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLV 188
K+++ ++L+ L + G+ NN+LG P +L Y ++E+ A H G I +++
Sbjct 144 KDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIA 203
Query 189 QPHVAGILNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQ 248
P + +LN+GTAHLGEFG R+ I + K+E+ Q + G +L ADD + + +
Sbjct 204 PPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAAR 263
Query 249 KM-LSFGQDGEIYATSVVL-HAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALA 306
+ +S G+++A V L F LH QA + L G+H V NAL A A AL
Sbjct 264 VVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALE 323
Query 307 IGIDLNNIVQGLSAAQG-AKGRLNFIQHGHHL-FIDDTYNANPGSMRAAAGVLA------ 358
G + + L+AA ++ R+ G + IDD YNANP SMRA LA
Sbjct 324 CGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQP 383
Query 359 QQTGIKVMVTGDIGELGDASMLEHTQLGHDLANEQLDYIVAVGE------------FAGA 406
+ T V G++ ELG+ ++ EH ++G + +V VG GA
Sbjct 384 EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGA 443
Query 407 MQQGAASSDH 416
G A++DH
Sbjct 444 WGSGEATADH 453
>P0A5L5 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)]
Length=510
Score = 186 bits (472), Expect = 3e-56
Identities = 136/430 (32%), Positives = 202/430 (47%), Gaps = 46/430 (11%)
Query 30 NRQPEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVD-I 88
+R+ GT++ DSR G FLAL G R D HD A V G V + +P+ V I
Sbjct 27 HRRVTGTVE---FDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAI 83
Query 89 FQLIVSDTRLALGAL-------GAYRRQQYPK-------------LQVIALTGSSGKTTT 128
V+ + G L GA K L +I +TGSSGKT+T
Sbjct 84 VVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTST 143
Query 129 KEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLV 188
K+++ ++L+ L + G+ NN+LG P +L Y ++E+ A H G I +++
Sbjct 144 KDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIA 203
Query 189 QPHVAGILNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQ 248
P + +LN+GTAHLGEFG R+ I + K+E+ Q + G +L ADD + + +
Sbjct 204 PPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAAR 263
Query 249 KM-LSFGQDGEIYATSVVL-HAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALA 306
+ +S G+++A V L F LH QA + L G+H V NAL A A AL
Sbjct 264 VVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALE 323
Query 307 IGIDLNNIVQGLSAAQG-AKGRLNFIQHGHHL-FIDDTYNANPGSMRAAAGVLA------ 358
G + + L+AA ++ R+ G + IDD YNANP SMRA LA
Sbjct 324 CGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQP 383
Query 359 QQTGIKVMVTGDIGELGDASMLEHTQLGHDLANEQLDYIVAVGE------------FAGA 406
+ T V G++ ELG+ ++ EH ++G + +V VG GA
Sbjct 384 EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGA 443
Query 407 MQQGAASSDH 416
G A++DH
Sbjct 444 WGSGEATADH 453
>P9WJL0 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)]
Length=510
Score = 182 bits (463), Expect = 5e-55
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 36/415 (9%)
Query 30 NRQPEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVD-I 88
+R+ GT++ DSR G FL L G R D HD A V G V + +P+ V I
Sbjct 27 HRRVTGTVE---FDSRAIGPGGLFLRLPGARADGHDHAASAVAAGAAVVLAARPVGVPAI 83
Query 89 FQLIVSDTRLALGAL-------GAYRRQQYPK-------------LQVIALTGSSGKTTT 128
V+ + G L GA K L +I +TGSSGKT+T
Sbjct 84 VVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTST 143
Query 129 KEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLV 188
K+++ ++L+ L + G+ NN+LG P +L Y ++E+ A H G I +++
Sbjct 144 KDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIA 203
Query 189 QPHVAGILNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQ 248
P + +LN+GTAHLGEFG R+ I + K+E+ Q + G +L ADD + + +
Sbjct 204 PPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAAR 263
Query 249 KM-LSFGQDGEIYATSVVL-HAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALA 306
+ +S G+++A V L F LH QA + L G+H V NAL A A AL
Sbjct 264 VVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALE 323
Query 307 IGIDLNNIVQGLSAAQG-AKGRLNFIQHGHHL-FIDDTYNANPGSMRAAAGVLA------ 358
G + + L+AA ++ R+ G + IDD YNANP SMRA LA
Sbjct 324 CGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQP 383
Query 359 QQTGIKVMVTGDIGELGDASMLEHTQLGHDLANEQLDYIVAV--GEFAGAMQQGA 411
+ T V G++ ELG+ ++ EH ++G + +V V G AM GA
Sbjct 384 EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGA 438
>O83401 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
[Treponema pallidum (strain Nichols)]
Length=459
Score = 174 bits (440), Expect = 4e-52
Identities = 129/431 (30%), Positives = 203/431 (47%), Gaps = 24/431 (6%)
Query 43 DSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLD-----------VDIFQL 91
DSR D F+ L+G D H FV + +Q+G +++Q +
Sbjct 32 DSRAVVPRDLFIPLRGAHVDGHTFVEEALQKGAVATLIDQRYPHAGEYVAWCTRFGAACI 91
Query 92 IVSDTRLALGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNN 151
V DT AL L ++ +++P L I +TGSSGKTT KEM ++ S + T GNLN+
Sbjct 92 AVHDTLRALQDLASFYCKKFPALIRIGITGSSGKTTVKEMARAVFSERYRVVATPGNLNS 151
Query 152 DLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDG 211
++G+P L +R EH+ + ELG + +GE+ ++++ PH A I N+G AH+G G +
Sbjct 152 EIGLPQSLFFVRAEHEVGIFELGMNRRGEMRTLAQILVPHYAIITNVGCAHVGILGTQQA 211
Query 212 ICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFGQDGEIYATSVVLHAQSS 271
I K EI+ +P DD I +++ + Q G AT V+
Sbjct 212 IAEEKKEIFSQFTEHSVGFVP--DDAYRVFLSNIPYGRVVVYDQGGRGLATEVIDEGLRG 269
Query 272 EFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNFI 331
L+ QG+ + +P G HN +NALA A A +G+ I +G+ + GR + +
Sbjct 270 SRVLY--QGR-WIRVPLPGVHNAKNALAVIALAAQVGLPAEEIQRGMERVKPPFGR-SHV 325
Query 332 QHGHHLFIDDTYNANPGSMRAAAGVLAQQTGI-KVMVTGDIGELGDASMLEHTQLGHDLA 390
F+ D YNANP SM AA + A + + KV V GD+GELG + H ++ A
Sbjct 326 VCASLTFLLDCYNANPDSMAAALHLCAHISAVSKVYVLGDMGELGVTAAEAHYRVCVLAA 385
Query 391 NEQLDYIVAVG-EFAGAMQQGAASSDHPEKLKAFTTQAQALPFLIELIQQHQPQSMSFLF 449
+ G EF A+++ + + + + + L L E + + L
Sbjct 386 ASDARAVYVFGPEFCRAVRKVSWG-----RKRVYAFALEELSALQETLDAQLRRGDFVLV 440
Query 450 KGSRYTHMETL 460
KGSR +E L
Sbjct 441 KGSRSVALERL 451
>Q03523 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate
ligase [Bacillus subtilis (strain 168)]
Length=494
Score = 117 bits (294), Expect = 1e-31
Identities = 97/391 (25%), Positives = 168/391 (43%), Gaps = 27/391 (7%)
Query 28 HNNRQPEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVD 87
++++ PE I I DSR + G F+ +KG D HDF + V+ G + E+ +DV+
Sbjct 17 NDSQDPE--ITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDVN 74
Query 88 IFQLIVSDTRLALGALG-AYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTR 146
+ +IV + AL L A+ Q KLQ+I +TG++GKT+T M+ IL +
Sbjct 75 VPVIIVRQSLRALSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGKRTGLI 134
Query 147 GNLNNDLGVPMMLLE-LRPEHQYAVMELGASHQGEIDYTSKLVQPH-------------V 192
G + +G + ++ PE + +D V H +
Sbjct 135 GTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDI 194
Query 193 AGILNIGTAHLGEFGGRDGICRAKSEIYQHIAV------DGTAILPADDDFTDQIKQAIQ 246
A N+ HL D AKS ++ + A+L ADD+ + ++ +
Sbjct 195 AVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYFEK-VT 253
Query 247 TQKMLSFG--QDGEIYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFA 304
+ ++G D ++ A ++ + AQ + FDL T +G H+++ G+ NV N LAA A
Sbjct 254 AAHISTYGIKNDADVMAKNISITAQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATC 313
Query 305 LAIGIDLNNIVQGLSAAQGAKGRLNFIQHGHHLFIDDTYNANPGSMRAAAGVLAQQT-GI 363
+A GI I + + G +GR + + Y P S+ T G
Sbjct 314 IAAGIPFEIITEAVEELHGVRGRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGK 373
Query 364 KVMVTGDIGELGDASMLEHTQLGHDLANEQL 394
+V G G+ + ++ +LA+E +
Sbjct 374 LFVVVGCGGDRDKTKRPKMAKIAVELADEPI 404
>Q819Q0 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate
ligase [Bacillus cereus (strain ATCC 14579 / DSM 31
/ CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599
/ NRRL B-3711)]
Length=491
Score = 111 bits (278), Expect = 1e-29
Identities = 87/337 (26%), Positives = 147/337 (44%), Gaps = 24/337 (7%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQLIVSDT 96
I I DSR + G F+ +KG D+HDF Q QG + E+P+DVD+ ++V +T
Sbjct 23 ITSIEADSRKVKEGSLFVCMKGYTVDSHDFAKQAAAQGAAAIVAERPIDVDVPVVLVKNT 82
Query 97 RLALGALGAY-RRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDLG- 154
+L L Y Q KL +I +TG++GKTTT ++ I+ G +N +G
Sbjct 83 FRSLAVLADYFYGQPTHKLHLIGITGTNGKTTTSHIMDEIMRAHGHKTGLIGTINMKIGD 142
Query 155 VPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPH-------------VAGILNIGTA 201
+ P+ + +D T V H VA N+
Sbjct 143 ETFEVKNTTPDALTLQQTFSKMVEQGVDSTVMEVSSHALDLGRVHGCDYDVAVFTNLTQD 202
Query 202 HLGEFGGRDGICRAKSEIYQHIA------VDGTAILPADDDFTDQIKQAIQTQKMLSFGQ 255
HL + AK ++ + + A+L +DD+ T++ ++ ++++G
Sbjct 203 HLDYHKTMEEYKHAKGLLFAQLGNSYNHNREKYAVLNSDDNVTEEYMRS-TAATVVTYGI 261
Query 256 D--GEIYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNN 313
D +I A ++V+ + + F L TP ++++ G+ NV N LAATA L G+ L
Sbjct 262 DTTSDIMAKNIVMTSGGTTFTLVTPYESVNVTMKLIGKFNVYNVLAATAAGLVSGVKLET 321
Query 314 IVQGLSAAQGAKGRLNFIQHGHHLFIDDTYNANPGSM 350
I+ + G GR + G + + Y P S+
Sbjct 322 IIAVIKDLAGVPGRFEVVDGGQNYTVIVDYAHTPDSL 358
>O86491 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
[Staphylococcus aureus (strain COL)]
Length=493
Score = 99.8 bits (247), Expect = 1e-25
Identities = 97/389 (25%), Positives = 172/389 (44%), Gaps = 30/389 (8%)
Query 34 EGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIV--EQPLDVDIFQL 91
E I I TDSR A G F+A G D+H F V QGC++ +V EQ L ++ Q+
Sbjct 20 EQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANVTQV 79
Query 92 IVSDTRLALGALGAYRRQQYPKLQVI--ALTGSSGKTTTKEMLGSI---LSRLAPTLVTR 146
+V DT L + ++ A+ YP Q++ +TG++GKT+ M+ I L + + L T
Sbjct 80 VVPDT-LRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTN 138
Query 147 GNLNND-----LGVPMMLLELRPEHQYAV------MELGASHQGEIDYTSKLVQPHVAGI 195
G N+ + L + + AV M L S G + + V+ VA
Sbjct 139 GFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRGVEFDVAIF 198
Query 196 LNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGT----AILPADDDFTDQIKQAIQTQKML 251
N+ HL G + AKS ++ + D + +L DD F++ ++ + ++
Sbjct 199 SNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNNDDSFSEYLR-TVTPYEVF 257
Query 252 SFG--QDGEIYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGI 309
S+G ++ + A ++ Q FD TP G + P+ G+ N+ N +AA + G
Sbjct 258 SYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFNISNIMAAMIAVWSKGT 317
Query 310 DLNNIVQGLSAAQGAKGRLNFIQHGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTG 369
L I++ + + +GRL + + + Y M + A Q +K +
Sbjct 318 SLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKL--IDAVQPFVKQKLIF 375
Query 370 DIGELGDASMLEHTQLGHDLANEQLDYIV 398
+G G+ + + ++G + DY++
Sbjct 376 LVGMAGERDLTKTPEMGRVAC--RADYVI 402
Score = 25.4 bits (54), Expect = 0.074
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 14/81 (17%)
Query 109 QQYPKLQVIALTGSSGK---TTTKEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLELRPE 165
Q + K ++I L G +G+ T T EM G + R + T N ND P+
Sbjct 366 QPFVKQKLIFLVGMAGERDLTKTPEM-GRVACRADYVIFTPDNPAND----------DPK 414
Query 166 HQYAVMELGASHQGEIDYTSK 186
A + GA+HQ I++ +
Sbjct 415 MLTAELAKGATHQNYIEFDDR 435
>Q2FZP6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
[Staphylococcus aureus (strain NCTC 8325 / PS 47)]
Length=493
Score = 99.8 bits (247), Expect = 1e-25
Identities = 97/389 (25%), Positives = 172/389 (44%), Gaps = 30/389 (8%)
Query 34 EGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIV--EQPLDVDIFQL 91
E I I TDSR A G F+A G D+H F V QGC++ +V EQ L ++ Q+
Sbjct 20 EQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANVTQV 79
Query 92 IVSDTRLALGALGAYRRQQYPKLQVI--ALTGSSGKTTTKEMLGSI---LSRLAPTLVTR 146
+V DT L + ++ A+ YP Q++ +TG++GKT+ M+ I L + + L T
Sbjct 80 VVPDT-LRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTN 138
Query 147 GNLNND-----LGVPMMLLELRPEHQYAV------MELGASHQGEIDYTSKLVQPHVAGI 195
G N+ + L + + AV M L S G + + V+ VA
Sbjct 139 GFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRGVEFDVAIF 198
Query 196 LNIGTAHLGEFGGRDGICRAKSEIYQHIAVDGT----AILPADDDFTDQIKQAIQTQKML 251
N+ HL G + AKS ++ + D + +L DD F++ ++ + ++
Sbjct 199 SNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNNDDSFSEYLR-TVTPYEVF 257
Query 252 SFG--QDGEIYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGI 309
S+G ++ + A ++ Q FD TP G + P+ G+ N+ N +AA + G
Sbjct 258 SYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFNISNIMAAMIAVWSKGT 317
Query 310 DLNNIVQGLSAAQGAKGRLNFIQHGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTG 369
L I++ + + +GRL + + + Y M + A Q +K +
Sbjct 318 SLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKL--IDAVQPFVKQKLIF 375
Query 370 DIGELGDASMLEHTQLGHDLANEQLDYIV 398
+G G+ + + ++G + DY++
Sbjct 376 LVGMAGERDLTKTPEMGRVAC--RADYVI 402
Score = 25.4 bits (54), Expect = 0.074
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 14/81 (17%)
Query 109 QQYPKLQVIALTGSSGK---TTTKEMLGSILSRLAPTLVTRGNLNNDLGVPMMLLELRPE 165
Q + K ++I L G +G+ T T EM G + R + T N ND P+
Sbjct 366 QPFVKQKLIFLVGMAGERDLTKTPEM-GRVACRADYVIFTPDNPAND----------DPK 414
Query 166 HQYAVMELGASHQGEIDYTSK 186
A + GA+HQ I++ +
Sbjct 415 MLTAELAKGATHQNYIEFDDR 435
>Q9WY79 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase
[Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM
10099 / NBRC 100826 / MSB8)]
Length=490
Score = 87.8 bits (216), Expect = 1e-21
Identities = 75/317 (24%), Positives = 142/317 (45%), Gaps = 30/317 (9%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQLIVSDT 96
I + S + GD F+ +GE+FD+H+ + +V+++G +VE+ +D+D + V D+
Sbjct 25 ITGVSNHSSKVKKGDLFICRRGEKFDSHEIIPEVMEKGAVAVVVEREIDLDFPYIQVFDS 84
Query 97 RLALGALGA-YRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLA------PTLVTR--- 146
R + + + + + +TG++GKTTT M+ +L+ L T V R
Sbjct 85 RYFEAKVASLFFEDPWKDVLTFGVTGTNGKTTTTMMIYHMLTSLGERGSVLTTAVKRILG 144
Query 147 GNLNNDLGVP--MMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGI-------LN 197
+ +D+ P + +L E++ E G + LVQ V G+ N
Sbjct 145 NSYYDDITTPDAITILSAMKENR----EGGGKFFALEVSSHALVQQRVEGVRFDVGIFTN 200
Query 198 IGTAHLGEFGGRDGICRAKSEIYQHIAVDGTAILPADDDFTDQIKQAIQTQKMLSFG--Q 255
I HL G + +AK ++ + DG A+L ++ D + + ++FG +
Sbjct 201 ISRDHLDFHGTFENYLKAKLHLFDLLKDDGVAVL--NESLADAFN---RKSRKITFGTSK 255
Query 256 DGEIYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIV 315
+ + ++ + + ++F L TP G + G+ N NA AA A +G D ++
Sbjct 256 NADYRLGNIEVSWEGTQFVLETPDGLLKVFTRAIGDFNAYNAAAAIAALHQLGYDPKDLA 315
Query 316 QGLSAAQGAKGRLNFIQ 332
L G +GR ++
Sbjct 316 SSLETFTGVEGRFEVVR 332
>Q52953 UDP-N-acetylmuramoylalanine--D-glutamate ligase [Rhizobium
meliloti (strain 1021)]
Length=463
Score = 78.6 bits (192), Expect = 1e-18
Identities = 93/348 (27%), Positives = 149/348 (43%), Gaps = 35/348 (10%)
Query 44 SRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQL----IVSDTRLA 99
++ A AG A L+G D H F A V+ G + + VD+ I+ D L
Sbjct 46 AKAAAAGIATADLRGA--DWHAFAAFVLSPGVPLTHPKPHWSVDLAHQAGVEIIGDVELF 103
Query 100 LGALGAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPTLVTRGNLNNDLGVPMML 159
+ RR+ P IA+TG++GK+TT ++ IL GN+ G ++
Sbjct 104 VRE----RRKHAPDCPFIAITGTNGKSTTTALIAHILRTSGRDTQLGGNI----GTAVLT 155
Query 160 LELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGRDGICRAKSEI 219
L+ ++ V+E +S+Q ++ T + P +LN+ HL G K +
Sbjct 156 LDPPKAGRFYVVEC-SSYQIDLAPT---LDPTAGILLNLTPDHLDRHGTMQHYADIKERL 211
Query 220 YQHIAVDGTAILPADDDFTDQIKQAIQTQ--KMLSFGQ-----DGEIYATSVVLHAQSSE 272
+A GTA++ DD + I ++ K++ + +G S ++ AQ
Sbjct 212 ---VAGSGTAVVGVDDSLSSLIADRVERAGTKVVRISRRHPLAEGIYAEGSALMRAQDGA 268
Query 273 FDLHTPQGQAHLSLPFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNFI- 331
L T G HN QNA AA A LA+GI +IV GL + G K R+ +
Sbjct 269 SSLFTDLAGIQT---LRGGHNAQNAAAAIAACLAVGISGKDIVDGLRSFPGLKHRMQPVA 325
Query 332 QHGHHLFIDDTYNANPGSMRAAAGVLAQQTGIKVMVTGDIGELGDASM 379
+ G +F++D+ N AAA L+ I + G E G S+
Sbjct 326 KKGEVVFVNDSKATN---AEAAAPALSSYDRIYWIAGGLPKEGGITSL 370
>P22188 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate
ligase [Escherichia coli (strain K12)]
Length=495
Score = 75.1 bits (183), Expect = 2e-17
Identities = 83/330 (25%), Positives = 141/330 (43%), Gaps = 38/330 (12%)
Query 33 PEGTIKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVE---QPLDVDIF 89
P ++ + DSR A AGD F+A+ G + D ++ Q + QG I E + D +I
Sbjct 18 PSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIR 77
Query 90 Q------LIVSDTRLALGAL-GAYRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLAPT 142
+ + +S L AL G + + L+++ +TG++GKTTT ++L L
Sbjct 78 EMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEI 137
Query 143 LVTRGNLNNDLGVPMMLLE------LRPEHQYA-VMELGASHQGEIDYTSKLVQPHVAGI 195
G + N L ++ E + +H+ A +++ GA+ + LVQ VA +
Sbjct 138 SAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAAL 197
Query 196 -------LNIGTAHLGEFGGRDGICRAKSEIY-QHIAVDGTAILPADDD--------FTD 239
N+ HL G + AK +Y +H G AI+ ADD+ D
Sbjct 198 KFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHC--GQAIINADDEVGRRWLAKLPD 255
Query 240 QIKQAIQTQKMLSFGQDGE-IYATSVVLHAQSSEFDLHTPQGQAHLSLPFAGEHNVQNAL 298
+ A+ + ++ G + AT V H + + G + G NV N L
Sbjct 256 AV--AVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLL 313
Query 299 AATAFALAIGIDLNNIVQGLSAAQGAKGRL 328
A A LA+G L ++++ + Q GR+
Sbjct 314 LALATLLALGYPLADLLKTAARLQPVCGRM 343
>Q9HW02 UDP-N-acetylmuramate--L-alanine ligase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=480
Score = 71.2 bits (173), Expect = 3e-16
Identities = 71/247 (29%), Positives = 112/247 (45%), Gaps = 23/247 (9%)
Query 117 IALTGSSGKTTTKEMLGSILSR--LAPTLVTRGNLNNDLGVPMMLLELRPEHQYAVMELG 174
IA+ G+ GKTTT ++ S+ + L PT V G LN G L R Y V E
Sbjct 118 IAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNA-AGTNAQLGASR----YLVAEAD 172
Query 175 ASHQGEIDYTSKLVQPHVAGILNIGTAHLGEFGGR-DGICRAKSEIYQHIAVDGTAILPA 233
S D + +QP VA + NI H+ +GG + + + E ++ G A++
Sbjct 173 ES-----DASFLHLQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCV 227
Query 234 DDDFTDQIKQAIQTQKMLSFG--QDGEIYATSVVLHAQSSEFDLHTPQGQA-HLSLPFAG 290
DD +I I + +++G +D ++ A ++ + F + P+ + +S+ G
Sbjct 228 DDPVVREILPQI-ARPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPG 286
Query 291 EHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNF-----IQHGHHLFIDDTYNA 345
HNV N+LA A GI IVQGLS QG R ++ G + +DD Y
Sbjct 287 LHNVLNSLATIVIATDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDD-YGH 345
Query 346 NPGSMRA 352
+P + A
Sbjct 346 HPREVAA 352
>F4I3P9 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate
ligase MurE homolog, chloroplastic [Arabidopsis thaliana]
Length=772
Score = 68.2 bits (165), Expect = 4e-15
Identities = 76/345 (22%), Positives = 131/345 (38%), Gaps = 75/345 (22%)
Query 37 IKRILTDSRHAEAGDAFLALKGERFDAHDFVAQVVQQGCQVAIVEQPLDVDIFQ-----L 91
I I DSR AGD F+ G + +F+++ ++G + + +D++ +
Sbjct 265 ITGIQHDSRGVSAGDLFVCCLG----SENFLSEADKRGAVAVVASKEIDIEDTLGCRALV 320
Query 92 IVSDTRLALGALGA-YRRQQYPKLQVIALTGSSGKTTTKEMLGSILSRLA------PTLV 144
IV DT L AL + + R + VI +TG+ GKTTT ++ S+ + T+
Sbjct 321 IVEDTNAVLAALASSFYRHPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGVRTGMFSTVS 380
Query 145 TRGNLNNDLGVPMMLLELRPEHQYAVMELGASHQGEIDYTSKLVQPHVAGILNIGTAHLG 204
+ +N L P ++ + LVQ +A +L+ GT L
Sbjct 381 CYIHGDNKLDTP---------------------NATMNPDAVLVQSLMAKMLHNGTESLV 419
Query 205 EFGGRDGICRAKSE-------IYQHIAVDGTAILPADDDFTDQIKQA------------- 244
+ K + ++ ++ + T D+++ D +
Sbjct 420 MEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMVDPERHRKV 479
Query 245 --IQTQKMLSFGQDGEIYATSVVLHAQSSEFDLH----------------TPQGQAHLSL 286
I F Q G V ++++ D+H TPQG +S
Sbjct 480 VNIDDPNAAFFVQQGNPNVPVVTFAMENTKADVHPLKFELSLFETQVLVNTPQGILEISS 539
Query 287 PFAGEHNVQNALAATAFALAIGIDLNNIVQGLSAAQGAKGRLNFI 331
G HN+ N LAA A +A+G L +IV+G+ GR I
Sbjct 540 GLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELI 584
Lambda K H a alpha
0.319 0.134 0.385 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3635815
Database: 56f402ae352d0b11d4825f77b16e23e5.SwissProt.fasta
Posted date: May 19, 2024 4:32 AM
Number of letters in database: 9,841
Number of sequences in database: 20
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
