BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: bf43845c6b56d02d94708c66ce417646.SwissProt.fasta
12 sequences; 4,929 total letters
Query= ACIAD3191
Length=391
Score E
Sequences producing significant alignments: (Bits) Value
P79274 Long-chain specific acyl-CoA dehydrogenase, mitochondrial ... 375 1e-131
P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial ... 372 2e-130
P15650 Long-chain specific acyl-CoA dehydrogenase, mitochondrial ... 371 4e-130
Q60HI0 Long-chain specific acyl-CoA dehydrogenase, mitochondrial ... 362 2e-126
P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial ... 360 8e-126
P45857 Acyl-CoA dehydrogenase [Bacillus subtilis (strain 168)] 249 5e-83
P45867 Acyl-CoA dehydrogenase [Bacillus subtilis (strain 168)] 238 1e-78
O34421 Probable acyl-CoA dehydrogenase YngJ [Bacillus subtilis (s... 235 1e-77
P12007 Isovaleryl-CoA dehydrogenase, mitochondrial [Rattus norveg... 231 2e-75
P52042 Acyl-CoA dehydrogenase, short-chain specific [Clostridium ... 229 4e-75
Q9FS87 Isovaleryl-CoA dehydrogenase, mitochondrial [Solanum tuber... 228 1e-74
P26440 Isovaleryl-CoA dehydrogenase, mitochondrial [Homo sapiens] 227 8e-74
>P79274 Long-chain specific acyl-CoA dehydrogenase, mitochondrial
[Sus scrofa]
Length=430
Score = 375 bits (964), Expect = 1e-131
Identities = 192/391 (49%), Positives = 268/391 (69%), Gaps = 1/391 (0%)
Query 1 MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGE 60
++S + + + + R +FS EH FR++VRKF+++EV+P+ ++E V R+LW KAG+
Sbjct 36 LESPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPHHAEWEKAGEVSRELWEKAGK 95
Query 61 LGLLCTTMPEQYGGSGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQ 120
GLL + E++GG G D + I+ EEQAY+ + GFSLHSDIV YI N+G+EEQ +
Sbjct 96 QGLLGINIAERHGGIGGDLYSAAIVWEEQAYSNCTGPGFSLHSDIVMPYIANYGSEEQIK 155
Query 121 KWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVV 180
++P+M G+ + AIAMTEPG GSDLQ VRT+A DG ++++NGSK+FITNG+L D+ +V
Sbjct 156 HFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKKDGSDWILNGSKVFITNGWLSDVVIV 215
Query 181 VCKTGNTDKGSAN-LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLG 239
V T + A+ +SL +VE GF KG+ L+KIG+K QDT ELFF++VR+P LLG
Sbjct 216 VAVTNREARSPAHGISLFLVENGMKGFVKGRKLHKIGLKAQDTAELFFEDVRLPASALLG 275
Query 240 MEGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLA 299
E GF LM+EL ER+L+A + + +E F T Y K RKAFGK + Q + KLA
Sbjct 276 EENKGFYYLMQELPQERLLIAELAVSASEFMFEETRNYVKQRKAFGKTVAHIQTVQHKLA 335
Query 300 ELRTEIDFCRAYLDRCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLE 359
EL+T I RA++D C+QL ++L AA+ AKY S++ + V +C+QLHGG+GYM E
Sbjct 336 ELKTHICVTRAFVDSCLQLHETKRLESAAASMAKYWASELQNSVAYDCVQLHGGWGYMWE 395
Query 360 YPIARAYIDNRANRIYAGTNEIMKELISRTL 390
YPIARAY+D R IY GTNEIMKELI+R +
Sbjct 396 YPIARAYVDARVQPIYGGTNEIMKELIAREI 426
Score = 23.5 bits (49), Expect = 0.12
Identities = 11/38 (29%), Positives = 19/38 (50%), Gaps = 0/38 (0%)
Query 351 HGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISR 388
H G LE P A+ D RI++ ++I +E + +
Sbjct 29 HSGGEERLESPSAKKLTDIGIRRIFSSEHDIFRESVRK 66
>P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial
[Mus musculus]
Length=430
Score = 372 bits (956), Expect = 2e-130
Identities = 188/377 (50%), Positives = 259/377 (69%), Gaps = 1/377 (0%)
Query 15 RNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGG 74
R +FS EH FR++VRKF+++EV+P+ ++E V R++W KAG+ GLL + E++GG
Sbjct 50 RRIFSSEHDIFRESVRKFFQEEVIPHHTEWEKAGEVSREVWEKAGKQGLLGINIAEKHGG 109
Query 75 SGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTA 134
G D L + + EEQAY+ + GFSLHSDIV YI N+G +EQ +K++P+M G+ + A
Sbjct 110 IGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEKFIPQMTAGKCIGA 169
Query 135 IAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSAN- 193
IAMTEPG GSDLQ VRT+A G ++++NGSK+FITNG+L D+ +VV T + A+
Sbjct 170 IAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHG 229
Query 194 LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELA 253
+SL +VE GF KG+ L+K+GMK QDT ELFF++VR+P LLG E GF LM+EL
Sbjct 230 ISLFLVENGMKGFIKGRKLHKMGMKAQDTAELFFEDVRLPANALLGEENKGFYYLMQELP 289
Query 254 WERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLD 313
ER+L+A + + E F T Y K RKAFGK + Q + KLAEL+T I RA++D
Sbjct 290 QERLLIAELAISACEFMFEETRNYVKQRKAFGKTVAHIQTVQHKLAELKTHICVTRAFVD 349
Query 314 RCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANR 373
C+QL ++L +A+ AKY S++ + V EC+QLHGG+GYM EYPIA+AY+D R
Sbjct 350 SCLQLHETKRLDSGSASMAKYWASELQNSVAYECVQLHGGWGYMWEYPIAKAYVDARVQP 409
Query 374 IYAGTNEIMKELISRTL 390
IY GTNEIMKELI+R +
Sbjct 410 IYGGTNEIMKELIARQI 426
Score = 23.9 bits (50), Expect = 0.088
Identities = 11/38 (29%), Positives = 19/38 (50%), Gaps = 0/38 (0%)
Query 351 HGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISR 388
H G LE P A+ D RI++ ++I +E + +
Sbjct 29 HSGAEARLETPSAKKLTDVGIRRIFSSEHDIFRESVRK 66
>P15650 Long-chain specific acyl-CoA dehydrogenase, mitochondrial
[Rattus norvegicus]
Length=430
Score = 371 bits (953), Expect = 4e-130
Identities = 188/377 (50%), Positives = 259/377 (69%), Gaps = 1/377 (0%)
Query 15 RNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGG 74
R +FS EH FR++VRKF+++EV+P E++E V R+LW KAG+ GLL + E++GG
Sbjct 50 RRIFSSEHDIFRESVRKFFQEEVIPYHEEWEKAGEVSRELWEKAGKQGLLGINIAEKHGG 109
Query 75 SGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTA 134
G D L + + EEQAY+ + GFSLHSDIV YI N+G +EQ ++++P+M G+ + A
Sbjct 110 IGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEQFIPQMTAGKCIGA 169
Query 135 IAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSAN- 193
IAMTEPG GSDLQ VRT+A G ++++NGSK+FITNG+L D+ +VV T + A+
Sbjct 170 IAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHG 229
Query 194 LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELA 253
+SL +VE GF KGK L+K+GMK QDT ELFF++VR+P LLG E GF LM+EL
Sbjct 230 ISLFLVENGMKGFIKGKKLHKMGMKAQDTAELFFEDVRLPASALLGEENKGFYYLMQELP 289
Query 254 WERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLD 313
ER+L+A + + E F T Y + RKAFGK + Q + KLAEL+T I RA++D
Sbjct 290 QERLLIADLAISACEFMFEETRNYVRQRKAFGKTVAHIQTVQHKLAELKTNICVTRAFVD 349
Query 314 RCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANR 373
C+QL ++L +A+ AKY S++ + V +C+QLHGG+GYM EYPIA+AY+D R
Sbjct 350 SCLQLHETKRLDSASASMAKYWASELQNTVAYQCVQLHGGWGYMWEYPIAKAYVDARVQP 409
Query 374 IYAGTNEIMKELISRTL 390
IY GTNEIMKELI+R +
Sbjct 410 IYGGTNEIMKELIARQI 426
Score = 23.9 bits (50), Expect = 0.088
Identities = 11/38 (29%), Positives = 19/38 (50%), Gaps = 0/38 (0%)
Query 351 HGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISR 388
H G LE P A+ D RI++ ++I +E + +
Sbjct 29 HSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRK 66
>Q60HI0 Long-chain specific acyl-CoA dehydrogenase, mitochondrial
[Macaca fascicularis]
Length=430
Score = 362 bits (929), Expect = 2e-126
Identities = 181/377 (48%), Positives = 255/377 (68%), Gaps = 1/377 (0%)
Query 15 RNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGG 74
R +FS EH FR ++RKF+++EV+P+ ++E V R++W KAG+ GLL + E GG
Sbjct 50 RRIFSSEHDIFRKSIRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGG 109
Query 75 SGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTA 134
G D Y+ ++ EEQAY+ S GFS+HS IV +YI N+G+EEQ + ++P+M G+ + A
Sbjct 110 IGGDLYYAAVVWEEQAYSNCSGPGFSVHSGIVMSYITNYGSEEQIKHFIPQMTAGKCIGA 169
Query 135 IAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSAN- 193
IAMTE G GSDLQ ++T+A DG ++++NGSK+FI+NG+L D+ +VV T + A
Sbjct 170 IAMTELGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGWLSDVVIVVAVTNHEAPSPARG 229
Query 194 LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELA 253
+SL +VE GF KG+ L+K+G+K QDT ELFF++VR+P LLG E GF +MKEL
Sbjct 230 ISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDVRLPASALLGEENKGFYYIMKELP 289
Query 254 WERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLD 313
ER+L+A + + +E F T Y K RKAFGK + Q + KLAEL+T I RA++D
Sbjct 290 QERLLIADMAVSASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVD 349
Query 314 RCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANR 373
C+QL ++L A AKY S++ + V +C+QLHGG+GYM EYPIA+AY+D R
Sbjct 350 NCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQP 409
Query 374 IYAGTNEIMKELISRTL 390
IY GTNEIMKELI+R +
Sbjct 410 IYGGTNEIMKELIAREI 426
Score = 21.9 bits (45), Expect = 0.35
Identities = 11/38 (29%), Positives = 19/38 (50%), Gaps = 0/38 (0%)
Query 351 HGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISR 388
H G LE P A+ D RI++ ++I ++ I +
Sbjct 29 HSGGEERLETPSAKNLTDIGIRRIFSSEHDIFRKSIRK 66
>P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial
[Homo sapiens]
Length=430
Score = 360 bits (925), Expect = 8e-126
Identities = 182/377 (48%), Positives = 254/377 (67%), Gaps = 1/377 (0%)
Query 15 RNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGG 74
R +FS EH FR +VRKF+++EV+P+ ++E V R++W KAG+ GLL + E GG
Sbjct 50 RRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGG 109
Query 75 SGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTA 134
G D + I+ EEQAY+ S GFS+HS IV +YI N G+EEQ + ++P+M G+ + A
Sbjct 110 IGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGA 169
Query 135 IAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSAN- 193
IAMTEPG GSDLQ ++T+A DG ++++NGSK+FI+NG L D+ +VV T + A+
Sbjct 170 IAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHG 229
Query 194 LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELA 253
+SL +VE GF KG+ L+K+G+K QDT ELFF+++R+P LLG E GF +MKEL
Sbjct 230 ISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELP 289
Query 254 WERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLD 313
ER+L+A + + +E F T Y K RKAFGK + Q + KLAEL+T I RA++D
Sbjct 290 QERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVD 349
Query 314 RCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANR 373
C+QL ++L A AKY S++ + V +C+QLHGG+GYM EYPIA+AY+D R
Sbjct 350 NCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQP 409
Query 374 IYAGTNEIMKELISRTL 390
IY GTNEIMKELI+R +
Sbjct 410 IYGGTNEIMKELIAREI 426
Score = 21.2 bits (43), Expect = 0.62
Identities = 10/38 (26%), Positives = 19/38 (50%), Gaps = 0/38 (0%)
Query 351 HGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISR 388
H G LE P A+ D RI++ ++I ++ + +
Sbjct 29 HSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRK 66
>P45857 Acyl-CoA dehydrogenase [Bacillus subtilis (strain 168)]
Length=379
Score = 249 bits (636), Expect = 5e-83
Identities = 147/374 (39%), Positives = 206/374 (55%), Gaps = 4/374 (1%)
Query 19 SEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVD 78
++E R VR F KE+ P E E L K G+ GL+ +PEQYGG+G D
Sbjct 4 TQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMGKHGLMGIPVPEQYGGAGAD 63
Query 79 RLYSMILIEEQAYAMDSSTG--FSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIA 136
+ S IL + + ++ G S+H+ + N I FGNEEQK K++P +A+G+ + A A
Sbjct 64 -VVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNEEQKMKYIPNLASGDHLGAFA 122
Query 137 MTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSL 196
+TEP +GSD ++RT+A+ +Y++NGSKIFITNG D+ + T D+G +S
Sbjct 123 LTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGAADIYITFALTA-PDQGRHGISA 181
Query 197 IIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELAWER 256
IVE + GF GK K+G+ G +T EL FDN VP+ NLLG EG GF + M L R
Sbjct 182 FIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVPEANLLGKEGDGFHIAMANLNVGR 241
Query 257 MLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCM 316
+ +A AEAA H V Y K R FG+PI Q FKLA++ T + R +
Sbjct 242 IGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAANQGISFKLADMATRAEAARHLVYHAA 301
Query 317 QLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYA 376
L A+ AK SD K + +Q++GGYGYM +YP+ R D + +IY
Sbjct 302 DLHNRGLNCGKEASMAKQFASDAAVKAALDAVQIYGGYGYMKDYPVERLLRDAKVTQIYE 361
Query 377 GTNEIMKELISRTL 390
GTNEI + +IS+ L
Sbjct 362 GTNEIQRLIISKYL 375
>P45867 Acyl-CoA dehydrogenase [Bacillus subtilis (strain 168)]
Length=379
Score = 238 bits (606), Expect = 1e-78
Identities = 144/374 (39%), Positives = 206/374 (55%), Gaps = 4/374 (1%)
Query 19 SEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVD 78
SEEH R VR F + EV P + + Q+ DR+L+ + LGL PE YGG G D
Sbjct 6 SEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYGGIGSD 65
Query 79 RLYSMILIEEQAYAMDSSTGFSL--HSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIA 136
L +I +EE + +STG +L H + + + FG EEQK ++L ++A GE + A A
Sbjct 66 YLAYVIAVEELSKVC-ASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKIGAFA 124
Query 137 MTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSL 196
+TE G+GSD +++T+A GD+YV+NGSK+FITNG + D+ +V T + +K ++
Sbjct 125 LTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNGGVADIYIVFAVT-DPEKKKKGVTA 183
Query 197 IIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELAWER 256
IVE D GF GK K+G++ T E+ F++ VP LG EG GF + MK L R
Sbjct 184 FIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLDGGR 243
Query 257 MLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCM 316
+A A+ A +QY K+RK FGK I Q FKLA++ T I+ R +
Sbjct 244 NGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTYQAA 303
Query 317 QLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYA 376
L+ A+A +K D KV E +Q+ GGYGY +YP+ R D + +IY
Sbjct 304 WLESSGLPYGKASAMSKLMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQIYE 363
Query 377 GTNEIMKELISRTL 390
GT EI + +ISR L
Sbjct 364 GTQEIQRLVISRML 377
>O34421 Probable acyl-CoA dehydrogenase YngJ [Bacillus subtilis
(strain 168)]
Length=380
Score = 235 bits (600), Expect = 1e-77
Identities = 135/374 (36%), Positives = 204/374 (55%), Gaps = 3/374 (1%)
Query 19 SEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVD 78
++E R+ V+ F +KE+ P+ E + + K GELGL+ PE+YGGSG D
Sbjct 6 TKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKKMGELGLMGIPFPEEYGGSGGD 65
Query 79 RLYSMILIEEQAYAMDSSTGFSLHSDIV--ANYIHNFGNEEQKQKWLPKMATGEVVTAIA 136
+ + +EE A STG S + + A+ ++ FG EEQKQ L +A+G + +
Sbjct 66 TISYALAVEEVGKAC-GSTGLSYAAAVSLGASPLYYFGTEEQKQTHLTPLASGTALGSFG 124
Query 137 MTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSL 196
+TEP GSD +T A+ +GDEYVING K +ITN +V TG G +S
Sbjct 125 LTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNASYARTVIVTAVTGKNKDGKNIISA 184
Query 197 IIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELAWER 256
+IV D G P +K+G++G +T E+ ++VRVP NLLG GF + L R
Sbjct 185 LIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDVRVPAANLLGDPTKGFKQFLYTLDGGR 244
Query 257 MLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCM 316
+ +A + A+AA ++ Y K+RK FG+PI +FQ +FKLA++ EID R + +
Sbjct 245 ISIAALAVGIAQAALDASLAYAKERKQFGQPISSFQAIQFKLADMAMEIDLARQMVLKAA 304
Query 317 QLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYA 376
L+ + AA AK S+M ++ ++ +Q+HGG GYM EY + R D + I
Sbjct 305 WLKDHNRPFTKEAAYAKLFASEMATRACNQAIQIHGGSGYMKEYGVERMLRDAKLMEIGE 364
Query 377 GTNEIMKELISRTL 390
GT+EI + +I+R L
Sbjct 365 GTSEIQRLVIARQL 378
>P12007 Isovaleryl-CoA dehydrogenase, mitochondrial [Rattus norvegicus]
Length=424
Score = 231 bits (589), Expect = 2e-75
Identities = 135/385 (35%), Positives = 214/385 (56%), Gaps = 6/385 (2%)
Query 8 PIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVD--RDLWNKAGELGLLC 65
P+D + N +EE R T+ KF ++ + P ++ + R+ W + G LG+L
Sbjct 35 PVDDDI--NGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLG 92
Query 66 TTMPEQYGGSGVDRLYSMILIEEQAYAMDS-STGFSLHSDIVANYIHNFGNEEQKQKWLP 124
T P QYGGSG+ L ++++EE + A + + HS++ N I GNE QK+K+LP
Sbjct 93 ITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLP 152
Query 125 KMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKT 184
K+ +GE + A+AM+EP GSD+ ++R A GD YV+NG+K +ITNG D+ VV KT
Sbjct 153 KLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKT 212
Query 185 GNTD-KGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGM 243
T S ++ IVE D GF+ K L+K+GM+G +TCEL F++ +VP N+L E
Sbjct 213 DLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESK 272
Query 244 GFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRT 303
G +LM L ER+++A +A HT+ Y R+AFG+ IG FQ + K+A++ T
Sbjct 273 GVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYT 332
Query 304 EIDFCRAYLDRCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIA 363
+ CR Y+ + E + A ++ ++V + +Q GG GY+ ++P+
Sbjct 333 RLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMG 392
Query 364 RAYIDNRANRIYAGTNEIMKELISR 388
R D + I GT+E+ + +I R
Sbjct 393 RFLRDAKLYEIGGGTSEVRRLVIGR 417
>P52042 Acyl-CoA dehydrogenase, short-chain specific [Clostridium
acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG
5710 / VKM B-1787)]
Length=379
Score = 229 bits (583), Expect = 4e-75
Identities = 137/371 (37%), Positives = 203/371 (55%), Gaps = 4/371 (1%)
Query 19 SEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVD 78
+ E R VR+F E EV P + + + + K G+ G++ ++YGG+G D
Sbjct 6 TREQELVRQMVREFAENEVKPIAAEIDETERFPMENVKKMGQYGMMGIPFSKEYGGAGGD 65
Query 79 RLYSMILIEEQAYAMDSSTG--FSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIA 136
L +I +EE + +TG S H+ + A+ I+ G EEQKQK+L +A GE + A
Sbjct 66 VLSYIIAVEELSKVC-GTTGVILSAHTSLCASLINEHGTEEQKQKYLVPLAKGEKIGAYG 124
Query 137 MTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSL 196
+TEP G+D A +T AVL+GD YVINGSKIFITNG + D V+ T T KG+ +S
Sbjct 125 LTEPNAGTDSGAQQTVAVLEGDHYVINGSKIFITNGGVADTFVIFAMTDRT-KGTKGISA 183
Query 197 IIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELAWER 256
I+E GF+ GK K+G++ T EL F+++ VP EN++G EG GF + MK L R
Sbjct 184 FIIEKGFKGFSIGKVEQKLGIRASSTTELVFEDMIVPVENMIGKEGKGFPIAMKTLDGGR 243
Query 257 MLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCM 316
+ +A AE AF Y K+RK FG+ + FQ + +A++ I+ R + +
Sbjct 244 IGIAAQALGIAEGAFNEARAYMKERKQFGRSLDKFQGLAWMMADMDVAIESARYLVYKAA 303
Query 317 QLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYA 376
L+ AA AK +++ V + +QL GGYGY +YP+ R D + IY
Sbjct 304 YLKQAGLPYTVDAARAKLHAANVAMDVTTKAVQLFGGYGYTKDYPVERMMRDAKITEIYE 363
Query 377 GTNEIMKELIS 387
GT+E+ K +IS
Sbjct 364 GTSEVQKLVIS 374
>Q9FS87 Isovaleryl-CoA dehydrogenase, mitochondrial [Solanum tuberosum]
Length=412
Score = 228 bits (582), Expect = 1e-74
Identities = 134/377 (36%), Positives = 207/377 (55%), Gaps = 4/377 (1%)
Query 17 LFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRD--LWNKAGELGLLCTTMPEQYGG 74
LF + F+++V +F ++ + P+ EK + + +D LW G LL T+PE+YGG
Sbjct 33 LFDDTQKQFKESVAQFAQENIAPHAEKIDRTNYFPQDVNLWKLMGNFNLLGITVPEEYGG 92
Query 75 SGVDRLYSMILIEEQAYAMDS-STGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVT 133
G+ LY I +EE + A S + H+++ N + G EQKQK+LPK+ +GE V
Sbjct 93 LGLGYLYHCIAMEEISRASGSVGLSYGAHTNLCINQLVRNGTHEQKQKYLPKLISGEHVG 152
Query 134 AIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVVCKTGNTDKGSAN 193
A+AM+EP GSD+ +++ A YV+NG+K++ TNG VV KT T GS
Sbjct 153 ALAMSEPNAGSDVVSMKCKADRVEGGYVLNGNKMWCTNGPTAQTLVVYAKTDVT-AGSKG 211
Query 194 LSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFMMLMKELA 253
++ I+E GF+ + L+K+GM+G DTCEL F+N VP+EN+LG G G +LM L
Sbjct 212 ITAFIIEKGMTGFSTAQKLDKLGMRGSDTCELVFENCFVPEENVLGQVGRGVYVLMSGLD 271
Query 254 WERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLD 313
ER+++A +A + Y K R+ FG+PIG FQ + K+A++ T + R+YL
Sbjct 272 LERLVLASGPVGIMQACLDVVLPYVKQREQFGRPIGEFQFVQGKVADMYTSMQSSRSYLY 331
Query 314 RCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANR 373
+ + A ++ ++V + +Q GG GY+ EYP R D +
Sbjct 332 SVARECDSGTINTKDCAGVILSAAERATQVALQAIQCLGGNGYVNEYPTGRFLRDAKLYE 391
Query 374 IYAGTNEIMKELISRTL 390
I AGT+EI + +I R L
Sbjct 392 IGAGTSEIRRMIIGREL 408
>P26440 Isovaleryl-CoA dehydrogenase, mitochondrial [Homo sapiens]
Length=426
Score = 227 bits (578), Expect = 8e-74
Identities = 130/388 (34%), Positives = 215/388 (55%), Gaps = 6/388 (2%)
Query 5 AIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVD--RDLWNKAGELG 62
++ P+D + N SEE R T+ KF ++ + P ++ + R+ W + G LG
Sbjct 34 SLLPVDDAI--NGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLG 91
Query 63 LLCTTMPEQYGGSGVDRLYSMILIEEQAYAMDS-STGFSLHSDIVANYIHNFGNEEQKQK 121
+L T P QYGGSG+ L ++++EE + A + + HS++ N + GNE QK+K
Sbjct 92 VLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEK 151
Query 122 WLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVVV 181
+LPK+ +GE + A+AM+EP GSD+ +++ A G+ Y++NG+K +ITNG D+ +V
Sbjct 152 YLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVY 211
Query 182 CKTG-NTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM 240
KT S ++ IVE GF+ K L+K+GM+G +TCEL F++ ++P N+LG
Sbjct 212 AKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGH 271
Query 241 EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAE 300
E G +LM L ER+++A +A HT+ Y R+AFG+ IG FQ + K+A+
Sbjct 272 ENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMAD 331
Query 301 LRTEIDFCRAYLDRCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEY 360
+ T + CR Y+ + E A ++ ++V + +Q GG GY+ ++
Sbjct 332 MYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDF 391
Query 361 PIARAYIDNRANRIYAGTNEIMKELISR 388
P+ R D + I AGT+E+ + +I R
Sbjct 392 PMGRFLRDAKLYEIGAGTSEVRRLVIGR 419
Lambda K H a alpha
0.322 0.137 0.402 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1493079
Database: bf43845c6b56d02d94708c66ce417646.SwissProt.fasta
Posted date: May 18, 2024 6:10 PM
Number of letters in database: 4,929
Number of sequences in database: 12
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
