BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: e677964bef93ddb20d8c57875706d0a1.SwissProt.fasta
16 sequences; 6,218 total letters
Query= ACIAD0247
Length=363
Score E
Sequences producing significant alignments: (Bits) Value
P44326 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 303 2e-104
P25539 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 296 1e-101
Q89AB0 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 263 1e-88
P70814 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 258 1e-86
O66534 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 251 3e-84
P17618 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 251 4e-84
P50853 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 228 5e-75
Q9PLJ6 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 213 2e-69
Q9Z735 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 213 4e-69
Q55158 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-... 207 3e-67
B6TRH4 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / In... 170 1e-52
Q8GWP5 Diaminohydroxyphosphoribosylaminopyrimidine deaminase / In... 168 1e-51
K7WIZ6 Inactive diaminohydroxyphosphoribosylaminopyrimidine deami... 120 4e-33
Q9STY4 Inactive diaminohydroxyphosphoribosylaminopyrimidine deami... 117 5e-32
P33312 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate... 59.3 2e-13
Q6FU96 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate... 51.2 1e-10
>P44326 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Haemophilus
influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=372
Score = 303 bits (775), Expect = 2e-104
Identities = 176/363 (48%), Positives = 231/363 (64%), Gaps = 11/363 (3%)
Query 6 RDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGV 65
+D +M +AL LA Q+ T PNP+VGCV+VK+ IVG G G PHAE AL +AG
Sbjct 7 QDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVALAQAGE 66
Query 66 QAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGIT 125
A+ ATAYVTLEPC+HYGRTPPCA LIEAGV +V+ A DPNP VAGKG ML+ AGI
Sbjct 67 NAKGATAYVTLEPCAHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKMLSDAGIE 126
Query 126 TQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQ 185
+ V +L +QA+++N+GFLK M G+P+V+LK+A SLDGRTAMASGESKWITG DAR DVQ
Sbjct 127 STVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAMSLDGRTAMASGESKWITGPDARSDVQ 186
Query 186 YWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSE------IVQPKRIILDRQGRLPLT 239
RA+S A+++ TV+ADD LNVR ++L + QP R+ILD Q R+ T
Sbjct 187 KMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQHRIQPT 246
Query 240 AKL-LQHPETVVVMGPFRQELADLGVVQFPVLPLQQLLEHIAKE---HHIYDVMIEAGAT 295
KL L H +V R + + P + LL+ + +E I + +EAGA
Sbjct 247 HKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLWVEAGAN 306
Query 296 LSTAFLQEDLVDEVISYVAPTLLGCSARAMFN-AELDKMAQQLRFELIDLTQLGQDIRLR 354
LS + + LVDE+I Y+AP LLG +AR + L K+A ++L +L Q+G DI+L
Sbjct 307 LSGSLIDAKLVDELIIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIGDDIKLT 366
Query 355 LVP 357
P
Sbjct 367 YTP 369
>P25539 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Escherichia
coli (strain K12)]
Length=367
Score = 296 bits (757), Expect = 1e-101
Identities = 175/366 (48%), Positives = 233/366 (64%), Gaps = 17/366 (5%)
Query 6 RDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGV 65
+D Y+M++AL LA+ +F T PNP VGCVIVKD IVG G G PHAEV ALR AG
Sbjct 2 QDEYYMARALKLAQRGRFTTHPNPNVGCVIVKDGEIVGEGYHQRAGEPHAEVHALRMAGE 61
Query 66 QAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGIT 125
+A+ ATAYVTLEPCSH+GRTPPC +ALI AGV+RVV + DPNP VAG+G L QAGI
Sbjct 62 KAKGATAYVTLEPCSHHGRTPPCCDALIAAGVARVVASMQDPNPQVAGRGLYRLQQAGID 121
Query 126 TQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQ 185
G++ +A++LN+GFLK M G PY++LK+ +SLDGRTAMASGES+WIT AR DVQ
Sbjct 122 VSHGLMMSEAEQLNKGFLKRMRTGFPYIQLKLGASLDGRTAMASGESQWITSPQARRDVQ 181
Query 186 YWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIV-------QPKRIILDRQGRLPL 238
RA+S AI+T TVLADD L VR ++D+ ++ + QP RI++D Q R+
Sbjct 182 LLRAQSHAILTSSATVLADDPALTVR-WSELDEQTQALYPQQNLRQPIRIVIDSQNRVTP 240
Query 239 TAKLLQHP-ET--VVVMGPFRQELADLGVVQFPV----LPLQQLLEHIAKEHHIYDVMIE 291
+++Q P ET R+ + + P L L L+ + K+ I + +E
Sbjct 241 VHRIVQQPGETWFARTQEDSREWPETVRTLLIPEHKGHLDLVVLMMQLGKQ-QINSIWVE 299
Query 292 AGATLSTAFLQEDLVDEVISYVAPTLLGCSARAMFNAE-LDKMAQQLRFELIDLTQLGQD 350
AG TL+ A LQ LVDE+I Y+AP LLG AR + L+K+A +F+ ++ +G D
Sbjct 300 AGPTLAGALLQAGLVDELIVYIAPKLLGSDARGLCTLPGLEKLADAPQFKFKEIRHVGPD 359
Query 351 IRLRLV 356
+ L LV
Sbjct 360 VCLHLV 365
>Q89AB0 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Buchnera
aphidicola subsp. Baizongia pistaciae (strain Bp)]
Length=372
Score = 263 bits (671), Expect = 1e-88
Identities = 142/369 (38%), Positives = 235/369 (64%), Gaps = 23/369 (6%)
Query 6 RDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGV 65
+D ++M +A+ LAK T PNP VGC+IV + IVG G G HAE++AL+ +G
Sbjct 2 KDIFYMKKAIKLAKKGSLTTSPNPNVGCIIVNNNIIVGSGWHKKTGMKHAEIYALKTSGE 61
Query 66 QAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGIT 125
+A+ ATAY+TLEPCSH+G+TPPC AL + G+SRVVIATLDPNP V+G G L + GI
Sbjct 62 KAKGATAYITLEPCSHFGKTPPCCVALTKYGISRVVIATLDPNPKVSGNGVKWLKKHGIL 121
Query 126 TQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQ 185
+G L +++ ++N+GF + M G+P+++LK+ASS+DGRTA+ +G+SKWIT AR DVQ
Sbjct 122 VTIGTLSKESIKINKGFFQRMTTGIPWIKLKLASSIDGRTALNNGKSKWITSDKARHDVQ 181
Query 186 YWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIV--------QPKRIILDRQGRLP 237
+ R +S AII+ +T+L D+ L VR + D+ +++ QP R+I+D + R+
Sbjct 182 HVREKSDAIISSSETILFDNPLLTVRNTNNNDNNQKLLKHSKTFLKQPIRVIIDSKNRIT 241
Query 238 LTAKLLQHPETVVVM----------GPFRQELADLGVVQFPVLPLQQLLEHIAKEHHIYD 287
+ K ++ P + ++ +Q + + + ++ L ++L ++ I +
Sbjct 242 PSHKCIKQPGLLFLIRIHSDNNIWPSHIKQIILNNKSKKIDLIDLVKML----AKYQINN 297
Query 288 VMIEAGATLSTAFLQEDLVDEVISYVAPTLLGCSARAMFNAE-LDKMAQQLRFELIDLTQ 346
++IEAG +LS++FL+ ++++E+I Y+AP +LG A+ +F E ++ +F+ +TQ
Sbjct 298 ILIEAGPSLSSSFLKLNIINELIIYIAPKILGNYAKPLFFLENYSNLSDVPQFKFEKITQ 357
Query 347 LGQDIRLRL 355
+G+D++L L
Sbjct 358 IGKDLKLIL 366
>P70814 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Bacillus
amyloliquefaciens]
Length=371
Score = 258 bits (658), Expect = 1e-86
Identities = 153/364 (42%), Positives = 217/364 (60%), Gaps = 20/364 (5%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQ 66
+ Y+M+ A+ LA+ + +T+PNP VG V+VK + IVG G+ G HAEV A+ AG
Sbjct 2 EEYYMNTAIELARRGEGQTQPNPLVGAVVVKKRQIVGMGAHLQYGEAHAEVHAINMAGSL 61
Query 67 AQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITT 126
A+ A YVTLEPCSHYG+TPPCA ++++G+ RV IA DPNPLVAGKG TML +AGI
Sbjct 62 AKGADLYVTLEPCSHYGKTPPCAELIMKSGIKRVFIAVEDPNPLVAGKGITMLEEAGIEV 121
Query 127 QVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQY 186
+ G+L +QA+ELN+ FL M GLPYV LK A+SLDG+TA +G+SKWIT ARLD Q
Sbjct 122 KTGLLRQQAEELNKMFLHFMRTGLPYVTLKAAASLDGKTATETGDSKWITSEAARLDAQQ 181
Query 187 WRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQH- 245
+R I+ G TV AD+ L R LPD + QP R+ILD + +P TA +L
Sbjct 182 YRKSHQRILVGAGTVKADNPSLTCR-LPDA-----VKQPVRVILDTKLTVPETANVLTDG 235
Query 246 --PETVVVMGPF----RQELADLGVVQFPV----LPLQQLLEHIAKEHHIYDVMIEAGAT 295
P + + L LG+ F + + + ++L +A E+ I V +E GA+
Sbjct 236 AAPTWIFTAAGSDVRKKDRLTALGIKVFTLETDRIHIPEVLSILA-ENGIMSVYVEGGAS 294
Query 296 LSTAFLQEDLVDEVISYVAPTLLGCS-ARAMFNAE-LDKMAQQLRFELIDLTQLGQDIRL 353
+ +F++ DE+ Y AP L+G + A ++ + E M + +TQ+G DI+L
Sbjct 295 VHGSFVKAGCFDELHFYFAPILIGGTLAPSLISGEGFQSMKDVPHLQFTQITQIGPDIKL 354
Query 354 RLVP 357
+P
Sbjct 355 TAIP 358
>O66534 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Aquifex
aeolicus (strain VF5)]
Length=356
Score = 251 bits (640), Expect = 3e-84
Identities = 146/354 (41%), Positives = 210/354 (59%), Gaps = 13/354 (4%)
Query 4 QERDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREA 63
+E D +M AL+LAK + T PNP VG V+VK+ IVG G G PHAEV AL +A
Sbjct 3 REIDKNYMKLALSLAKKRKGYTHPNPTVGAVVVKEGKIVGLGYHEKAGKPHAEVMALGQA 62
Query 64 GVQAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAG 123
G +A+ AT YVTLEPC+H+GRTPPC +A+I +G+ RVV+ATLDPNPL++GKG L AG
Sbjct 63 GEKAKGATLYVTLEPCTHFGRTPPCTDAIIRSGIKRVVVATLDPNPLMSGKGVEKLRNAG 122
Query 124 ITTQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLD 183
I VGV EE+A+ELN F + PY+ LK A +LDG+ A +G SKWIT ++R
Sbjct 123 IEVDVGVCEEEARELNEDFFTYITQERPYITLKWAQTLDGKLATLTGSSKWITSKESRKV 182
Query 184 VQYWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLL 243
R + A++ GV+TV+ DD L VR +P QP RIILD + +PL+AK+L
Sbjct 183 AHILRREATAVLVGVNTVIKDDPHLTVRFVPTEK------QPVRIILDPELEVPLSAKVL 236
Query 244 QHPE--TVVVMGPFRQELADLGVVQFPVLPLQQL-LEHI---AKEHHIYDVMIEAGATLS 297
E T+V+ ++ L VL L+ L++I KE I +M+E G
Sbjct 237 NTEEAPTIVITKKENEKAEKLKEKGVQVLILKGFNLKNILKKLKELEIMHLMVEGGPRTL 296
Query 298 TAFLQEDLVDEVISYVAPTLLGCSARAMFNAELDKMAQQLRFELIDLTQLGQDI 351
T+FL+E D ++ ++AP ++G ++ + + + + L+ + LG+D+
Sbjct 297 TSFLKEGFFDRIVVFIAPKIMG-EGLSIGDLGIRSIEESLKVRKKKVENLGEDL 349
>P17618 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Bacillus
subtilis (strain 168)]
Length=361
Score = 251 bits (640), Expect = 4e-84
Identities = 152/367 (41%), Positives = 214/367 (58%), Gaps = 20/367 (5%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQ 66
+ Y+M AL LAK + +T NP VG V+VKD IVG G+ G HAEV A+ AG
Sbjct 2 EEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLKYGEAHAEVHAIHMAGAH 61
Query 67 AQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITT 126
A+ A YVTLEPCSHYG+TPPCA +I +G+ RV +A DPNPLVAG+G +M+ +AGI
Sbjct 62 AEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDPNPLVAGRGISMMKEAGIEV 121
Query 127 QVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQY 186
+ G+L +QA+ LN FL M GLPYV LK A+SLDG+ A ++G+SKWIT AR D Q
Sbjct 122 REGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKIATSTGDSKWITSEAARQDAQQ 181
Query 187 WRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQH- 245
+R +I+ GV TV AD+ L R LP+V QP R+ILD +P AK++
Sbjct 182 YRKTHQSILVGVGTVKADNPSLTCR-LPNVTK-----QPVRVILDTVLSIPEDAKVICDQ 235
Query 246 --PETVVVMGPFRQE----LADLGVVQFPV----LPLQQLLEHIAKEHHIYDVMIEAGAT 295
P + +E L+ GV F + + + +L+ +A+E I V +E G+
Sbjct 236 IAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVLKILAEE-GIMSVYVEGGSA 294
Query 296 LSTAFLQEDLVDEVISYVAPTLL-GCSARAMFNAE-LDKMAQQLRFELIDLTQLGQDIRL 353
+ +F++E E+I Y AP L+ G A ++ + E M + D+TQ+G+DI+L
Sbjct 295 VHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSMKDVPLLQFTDITQIGRDIKL 354
Query 354 RLVPIQE 360
P +E
Sbjct 355 TAKPTKE 361
>P50853 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Actinobacillus
pleuropneumoniae]
Length=376
Score = 228 bits (580), Expect = 5e-75
Identities = 144/364 (40%), Positives = 201/364 (55%), Gaps = 23/364 (6%)
Query 10 WMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQAQN 69
+M +A+ALAK T PNP VGCVIVK+ IV G +GG HAE A+
Sbjct 18 YMRRAIALAKQGLGWTNPNPLVGCVIVKNGEIVAEGYHEKIGGWHAERNAVLHCKEDLSG 77
Query 70 ATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITTQVG 129
ATAYVTLEPC H+GRTPPC++ LIE G+ +V I + DPNPLVAG+G L QAG+ G
Sbjct 78 ATAYVTLEPCCHHGRTPPCSDLLIERGIKKVFIGSSDPNPLVAGRGANQLRQAGVEVVEG 137
Query 130 VLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQYWRA 189
+L+E+ LN F + PYV +K A + DG+ A SGESKWITG AR VQ R
Sbjct 138 LLKEECDALNPIFFHYIQTKRPYVLMKYAMTADGKIATGSGESKWITGESARARVQQTRH 197
Query 190 RSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQ----H 245
+ AI+ GVDTVLAD+ LN R + QP RI+ D Q R PL +L+Q +
Sbjct 198 QYSAIMVGVDTVLADNPMLNSR-------MPNAKQPVRIVCDSQLRTPLDCQLVQTAKEY 250
Query 246 PETVVVMGPFRQELADLGVVQFPVL---------PLQQLLEHIAKEHHIYDVMIEAGATL 296
+ + Q++ + VL LQ LL+ + E I +++E G++L
Sbjct 251 RTVIATVSDDLQKIEQFRPLGVDVLVCKARNKRVDLQDLLQKLG-EMQIDSLLLEGGSSL 309
Query 297 STAFLQEDLVDEVISYVAPTLL-GCSARAMFNAE-LDKMAQQLRFELIDLTQLGQDIRLR 354
+ + L+ +V+ V Y+AP L+ G A+ E + ++ Q ++ +L +G+DI L
Sbjct 310 NFSALESGIVNRVHCYIAPKLVGGKQAKTPIGGEGIQQIDQAVKLKLKSTELIGEDILLD 369
Query 355 LVPI 358
V I
Sbjct 370 YVVI 373
>Q9PLJ6 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Chlamydia
muridarum (strain MoPn / Nigg)]
Length=371
Score = 213 bits (542), Expect = 2e-69
Identities = 133/326 (41%), Positives = 192/326 (59%), Gaps = 15/326 (5%)
Query 5 ERDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAG 64
E+ ++M +A+AL + + PNP VGCVIVK+ I+GRG +G PHAEV A ++
Sbjct 6 EQQLFFMREAVALGERGRIFAPPNPWVGCVIVKNGCIIGRGWHKGIGSPHAEVCAFQDQT 65
Query 65 VQAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGI 124
A YVTLEPC H+GRTPPC + LI++ VS V IA LDP+P V +G L +AGI
Sbjct 66 SSLVGADVYVTLEPCCHFGRTPPCVDLLIKSKVSSVYIALLDPDPRVCKRGVARLKEAGI 125
Query 125 TTQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDV 184
+ VG+ E+A+ + +L GLP+V +K A+SLDG+T+ G S+WI+G ARLDV
Sbjct 126 SVYVGIGHEEAKASLQPYLHQRETGLPWVVMKTAASLDGQTSDRRGISQWISGEQARLDV 185
Query 185 QYWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQ 244
RA S A+I G TV D+ +L+ R +P DL E QP R+++D +G +PL A++
Sbjct 186 GRLRAESQAVIVGSRTVCLDNPRLSAR-MPS-GDLYE-RQPLRVVVDSRGSVPLDARVWN 242
Query 245 HPETVVVMGPFR-------QELADLGVVQFPVLP----LQQLLEHIAKEHHIYDVMIEAG 293
V++ Q+L D GV + P L++LL+++A E V++E G
Sbjct 243 PDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSSPQQVDLKRLLQYLA-EKGCLQVLVEGG 301
Query 294 ATLSTAFLQEDLVDEVISYVAPTLLG 319
A L +AF +E LV+ + Y P LG
Sbjct 302 ARLHSAFWREHLVNAGVIYWGPKFLG 327
>Q9Z735 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Chlamydia
pneumoniae]
Length=376
Score = 213 bits (541), Expect = 4e-69
Identities = 125/333 (38%), Positives = 188/333 (56%), Gaps = 16/333 (5%)
Query 5 ERDHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAG 64
E+ ++M +A+ + + + PNP VGCV+V++ I+G G A GGPHAE A++ A
Sbjct 6 EQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELAIQNAS 65
Query 65 VQAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGI 124
+ + YV+LEPCSH+G PPCAN LI+ VSRV +A +DP+P VAG+G ML QAGI
Sbjct 66 MPISGSDVYVSLEPCSHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAMLRQAGI 125
Query 125 TTQVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDV 184
VG+ E +AQ + +L P+ LK A+S+DG+ A + G+S+WIT +AR DV
Sbjct 126 QVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAASVDGQVADSQGKSQWITCPEARHDV 185
Query 185 QYWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQ 244
RA S AI+ G TVL+DD L R + QP R++LD +G +P T+K+
Sbjct 186 GKLRAESQAILVGSRTVLSDDPWLTAR---QPQGMLYPKQPLRVVLDSRGSVPPTSKVFD 242
Query 245 HPETVVVMGPFR---QELADLGVVQFPVL---------PLQQLLEHIAKEHHIYDVMIEA 292
+ + R + L + PVL L ++ E++A++ I V++E
Sbjct 243 KTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQK-KILQVLVEG 301
Query 293 GATLSTAFLQEDLVDEVISYVAPTLLGCSARAM 325
G TL T+ L+E V+ ++ Y P +LG R +
Sbjct 302 GTTLHTSLLKERFVNSLVLYSGPMILGDQKRPL 334
>Q55158 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [Synechocystis
sp. (strain PCC 6803 / Kazusa)]
Length=368
Score = 207 bits (527), Expect = 3e-67
Identities = 135/354 (38%), Positives = 189/354 (53%), Gaps = 17/354 (5%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQ 66
D M + L LAKTA +T PNP VG VIV+ IVG+G G PH E+FAL EAG +
Sbjct 4 DQTHMRRCLTLAKTAIGKTAPNPLVGSVIVQGDEIVGQGFHPQAGQPHGEIFALWEAGDR 63
Query 67 AQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITT 126
A+ AT YV LEPC+H GRTPPC A+I+AG+++VV+ +DPNPLVAGKG + L QAGI
Sbjct 64 AKGATLYVNLEPCNHQGRTPPCTEAIIQAGIAKVVVGMVDPNPLVAGKGISRLRQAGIEV 123
Query 127 QVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQY 186
+VGV EE Q LN F + P+ K A +LDG+ A A S W+T AR V
Sbjct 124 KVGVEEEACQRLNEAFCFRIKHQRPFGIFKYAMTLDGKIATAQAHSSWVTSSSARHWVHQ 183
Query 187 WRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQH- 245
R++ A+I G +TV D+ L + +V+ P R++L R LP+ A+L
Sbjct 184 LRSQCQAVIIGGNTVRRDNPLLTNHGVGEVN-------PLRVVLSRSLDLPIEAQLWDQD 236
Query 246 -PETVVVMGPF--RQELADLGVVQFPVLPLQQLLEHIAKE----HHIYDVMIEAGATLST 298
+T+V+ R L+ L ++ L L+QL E + V+ E G L+
Sbjct 237 VAKTLVITEKTCDRNTLSHLEKLEVETLVLEQLTPLAVMEELYQRNCLQVLWECGGILAA 296
Query 299 AFLQEDLVDEVISYVAPTLLGCSARAMFNAEL--DKMAQQLRFELIDLTQLGQD 350
+ V +V +++AP ++G A EL +M Q L + +G D
Sbjct 297 EAIAMGTVQKVHAFLAPKIIGGVAAPTPVGELGFQQMTQALNLTDLHCQAIGPD 350
>B6TRH4 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ Inactive 5-amino-6-(5-phosphoribosylamino)uracil reductase
[Zea mays]
Length=392
Score = 170 bits (430), Expect = 1e-52
Identities = 115/319 (36%), Positives = 167/319 (52%), Gaps = 23/319 (7%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQ 66
D ++M + + LA+ A T PNP VGCVIV+D +VG G G PHAEVFALR+AG
Sbjct 48 DAHYMRRCVELARKAAGHTSPNPMVGCVIVRDGRVVGEGFHPKAGQPHAEVFALRDAGNL 107
Query 67 AQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITT 126
A+NATAYV+LEPC+HYGRTPPC ALI A V VV+ DPNP+VA KG L AGI+
Sbjct 108 AENATAYVSLEPCNHYGRTPPCTEALINAKVKEVVVGMTDPNPIVASKGIEKLQGAGISV 167
Query 127 QVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQY 186
+VGV E ++LN ++ M G + L+ S++G G+ +G
Sbjct 168 RVGVEEALCRKLNEAYIHRMLTGKAFATLRATLSMNGIITNQIGKGADQSG--------- 218
Query 187 WRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIIL--DRQGRLPLTAKLLQ 244
++ D V+ + ALP + + QP II+ RL + + +
Sbjct 219 --GYYSQLMKEYDGVIISSDLAKMSALP-LSREAGTNQPLCIIIAQGESSRLHIPSLSQE 275
Query 245 HPETVVVM--GPFRQELADLGVVQFPVLPLQQLLEHIAKEHHIYDVMI---EAG---ATL 296
H +V+ P E A + V F + L+ +L+ +A + + V++ EAG A+L
Sbjct 276 HASRAIVLADSPVTVEPAGVEVAVFRQIDLESILQLLA-QRGLCSVLVDFREAGESFASL 334
Query 297 STAFLQEDLVDEVISYVAP 315
F ++ LV +V+ V P
Sbjct 335 LNDFQEDKLVQKVVVEVLP 353
>Q8GWP5 Diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ Inactive 5-amino-6-(5-phosphoribosylamino)uracil reductase
[Arabidopsis thaliana]
Length=426
Score = 168 bits (425), Expect = 1e-51
Identities = 85/157 (54%), Positives = 108/157 (69%), Gaps = 0/157 (0%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQHIVGRGSTAPVGGPHAEVFALREAGVQ 66
D ++M + + LAK A T PNP VGCVIVKD IVG+G G PHAEVFALR+AG
Sbjct 74 DSFYMRKCVELAKRAIGCTSPNPMVGCVIVKDGDIVGQGFHPKAGQPHAEVFALRDAGEL 133
Query 67 AQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGITT 126
A+NATAYV+LEPC+HYGRTPPC ALI+A V RVVI +DPNP+V G + L AGI
Sbjct 134 AENATAYVSLEPCNHYGRTPPCTEALIKAKVRRVVIGMVDPNPIVFSSGISRLKDAGIDV 193
Query 127 QVGVLEEQAQELNRGFLKVMAGGLPYVRLKVASSLDG 163
V V EE +++N GF+ M G P++ L+ + S++G
Sbjct 194 TVSVEEELCKKMNEGFIHRMLTGKPFLALRYSMSVNG 230
Score = 23.5 bits (49), Expect = 0.13
Identities = 11/49 (22%), Positives = 25/49 (51%), Gaps = 3/49 (6%)
Query 240 AKLLQHPETVVVMGPFRQELADLG---VVQFPVLPLQQLLEHIAKEHHI 285
+KLLQ + +++ EL+ + + + P+Q ++ A++ HI
Sbjct 248 SKLLQEYDAIILSSSLSDELSSISSQEAINVSIQPIQIIVASNAQQSHI 296
Score = 20.4 bits (41), Expect = 1.2
Identities = 8/27 (30%), Positives = 12/27 (44%), Gaps = 0/27 (0%)
Query 37 KDQHIVGRGSTAPVGGPHAEVFALREA 63
+ HI+ T GP VF +E+
Sbjct 292 QQSHILASSHTVEESGPKVVVFTAKES 318
Score = 18.5 bits (36), Expect = 5.0
Identities = 8/21 (38%), Positives = 13/21 (62%), Gaps = 0/21 (0%)
Query 189 ARSGAIITGVDTVLADDCQLN 209
A SG +GV+TV+ + L+
Sbjct 320 AESGISSSGVETVVLEKINLD 340
>K7WIZ6 Inactive diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase
/ Riboflavin biosynthesis intermediates N-glycosidase [Zea
mays]
Length=623
Score = 120 bits (300), Expect = 4e-33
Identities = 111/381 (29%), Positives = 175/381 (46%), Gaps = 42/381 (11%)
Query 2 SEQERDHYWMSQALALAKTAQFRTRPNPAVGCVIVK--------DQHIVGRGSTAPVGGP 53
S D + +A +A + T P+P GCVI + D +VG G G P
Sbjct 49 SSHANDAMLLRRAADVADRSAGLTSPHPNFGCVIARPQLNTDSADSWVVGEGFLYAQGTP 108
Query 54 HAEVFALREAGVQAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAG 113
AE+ A +EAG A+ TAY+ LEP +G +L++AG++RVV+ P + G
Sbjct 109 CAELLASQEAGEHARGGTAYLNLEPGDCFGDNT-AVGSLVQAGITRVVVGLRHPLKHLRG 167
Query 114 KGQTMLNQAGITTQVGVLEEQAQE------------LNRGFLKVMAGGLPYVRLKVASSL 161
K L GI QV V+ E Q +N L A +P+ LK A +
Sbjct 168 KAIQALRNEGI--QVDVVGEDLQSKLFKEALKSCLTVNAPLLYRAAFHVPFSVLKYAMTA 225
Query 162 DGRTAMASGESKWITGVDARLDVQYWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSE 221
DG+ A +SG + WI+G +R V R RS A+I G +TV DD +L R +
Sbjct 226 DGKIAASSGHASWISGKASRGRVFELRGRSDAVIVGGNTVRFDDPRLTARHVKG------ 279
Query 222 IVQPKRIILDRQGRLPLTAKL--LQHPETVV-----VMGPFRQELADLG--VVQFPVLPL 272
P RI++ + LP A L L T+V F+++LA G VV+F +L
Sbjct 280 -HVPVRIVMSQSLNLPEEANLWNLNDAYTIVATQRGARRDFQRKLAMKGVEVVEFDMLNP 338
Query 273 QQLLEHIAKEHHIYDVMIEAGATLSTAFLQEDLVDEVISYVAPTLLGCSARAMFNAELDK 332
+ ++ + ++ V+ E G TL+ + + ++ +V ++ AP ++G EL
Sbjct 339 RAVMSYCYDRGYL-AVLWECGGTLAASAISASVIHKVYAFWAPKIIGGLNAPTPVGELGM 397
Query 333 MAQQLRFELIDLT--QLGQDI 351
LID++ Q+ +D+
Sbjct 398 SQMTQAINLIDVSYEQIDRDM 418
>Q9STY4 Inactive diaminohydroxyphosphoribosylaminopyrimidine deaminase
/ 5-amino-6-(5-phosphoribosylamino)uracil reductase
/ Riboflavin biosynthesis intermediates N-glycosidase [Arabidopsis
thaliana]
Length=599
Score = 117 bits (292), Expect = 5e-32
Identities = 103/367 (28%), Positives = 173/367 (47%), Gaps = 31/367 (8%)
Query 7 DHYWMSQALALAKTAQFRTRPNPAVGCVIVKDQ-HIVGRGSTAPVGGPHAEVFALREAGV 65
D ++ +A L++ + T P+P GCVI + G G G AE A+ AG
Sbjct 32 DAAFIRRAADLSEMSAGLTSPHPNFGCVIATSSGKVAGEGYLYAQGTKPAEALAVEAAGE 91
Query 66 QAQNATAYVTLEPCSHYGRTPPCANALIEAGVSRVVIATLDPNPLVAGKGQTMLNQAGIT 125
++ ATAY+ +EP +G +AL++AG+ RVV+ P + G L GI
Sbjct 92 FSRGATAYLNMEPGDCHG-DHTAVSALVQAGIERVVVGIRHPLQHLRGSAIRELRSHGIE 150
Query 126 TQV-------GVLEEQAQE---LNRGFLKVMAGGLPYVRLKVASSLDGRTAMASGESKWI 175
V VLE+ + +N + +P+ LK A +LDG+ A +SG + WI
Sbjct 151 VNVLGEDFESKVLEDARKSCLLVNAPLIHRACSRVPFSVLKYAMTLDGKIAASSGHAAWI 210
Query 176 TGVDARLDVQYWRARSGAIITGVDTVLADDCQLNVRALPDVDDLSEIVQPKRIILDRQGR 235
+ +R V R S A+I G +TV DD +L R + P RI++ +
Sbjct 211 SSKLSRTRVFELRGGSDAVIVGGNTVRQDDPRLTARH-------GQGHTPTRIVMTQSLD 263
Query 236 LPLTAKL--LQHPETVVV-----MGPFRQELADLG--VVQFPVLPLQQLLEHIAKEHHIY 286
LP A L + T+VV F++ LA G VV+F +L ++++E+ ++
Sbjct 264 LPEKANLWDVSEVSTIVVTQRGARKSFQKLLASKGVEVVEFDMLNPREVMEYFHLRGYL- 322
Query 287 DVMIEAGATLSTAFLQEDLVDEVISYVAPTLLGCSARAMFNAELDKMAQQLRFELIDL-- 344
++ E G TL+ + + ++ +V+++VAP ++G S +L + LID+
Sbjct 323 SILWECGGTLAASAISSSVIHKVVAFVAPKIIGGSKAPSPVGDLGMVEMTQALNLIDVCY 382
Query 345 TQLGQDI 351
Q+G D+
Sbjct 383 EQVGPDM 389
>P33312 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate
reductase [Saccharomyces cerevisiae (strain ATCC 204508
/ S288c)]
Length=244
Score = 59.3 bits (142), Expect = 2e-13
Identities = 53/191 (28%), Positives = 84/191 (44%), Gaps = 27/191 (14%)
Query 150 LPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQYWRARSGAIITGVDTVLADDCQLN 209
+P+V L A SLD R + G I+ + + Y R I+ G TVLAD+ LN
Sbjct 29 VPFVTLTYAQSLDARVSRGPGVRTTISHPETKTMTHYLRHHHDGILVGSGTVLADNPGLN 88
Query 210 VRALPDVDDLSEIVQPKRIILDRQGRLPLTAKLLQH---------PETVVVMGPFRQELA 260
+ PD S P+ II+D + + +Q P VV P +E
Sbjct 89 CKWGPDPAANS----PRPIIIDTKQKWRFDGSKMQELFIKRQGKPPIVVVTSEPIIKEQH 144
Query 261 DLGVVQFPVLPL---------QQLLEHIAKEHHIYDVMIEAGA-TLSTAFLQEDLVDEVI 310
V + + P+ ++L E + +E +I VM+E GA ++ L+ D+V+ +I
Sbjct 145 ----VDYAICPINDTTKLVDWKKLFEILKEEFNIRSVMVEGGANVINQLLLRSDIVNSLI 200
Query 311 SYVAPTLLGCS 321
+ T LG S
Sbjct 201 ITIGSTFLGSS 211
>Q6FU96 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate
reductase [Candida glabrata (strain ATCC 2001 / BCRC 20586
/ JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)]
Length=244
Score = 51.2 bits (121), Expect = 1e-10
Identities = 46/188 (24%), Positives = 82/188 (44%), Gaps = 17/188 (9%)
Query 149 GLPYVRLKVASSLDGRTAMASGESKWITGVDARLDVQYWRARSGAIITGVDTVLADDCQL 208
G P+V L A S+D + A G I+ ++ + Y R I+ G TVLADD L
Sbjct 23 GRPFVTLTYAQSIDAKIAKQRGVRTTISHIETKEMTHYLRYFHDGILIGSGTVLADDPGL 82
Query 209 NVRAL---PDVDDLSEIVQPKRIILDRQGRLPLTAKLLQH---------PETVVVMGPFR 256
N + + D D+ E P+ IILD + + + ++ P + P
Sbjct 83 NCKWIGPNNDPDESMEEKSPRPIILDPKLKWKYSGSKMEELCNQGMGKPPIVITTKTPKV 142
Query 257 QELADLGVVQFP----VLPLQQLLEHIAKEHHIYDVMIEAGA-TLSTAFLQEDLVDEVIS 311
+E ++ P + + +L+ + + + + VMIE G+ ++ + DL+D +I
Sbjct 143 KEANVEYMIMEPDANDRISWKSILDTLRRNYDMKSVMIEGGSHVINQLLMCSDLIDSLIV 202
Query 312 YVAPTLLG 319
+ LG
Sbjct 203 TIGSIYLG 210
Lambda K H a alpha
0.322 0.136 0.398 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1706276
Database: e677964bef93ddb20d8c57875706d0a1.SwissProt.fasta
Posted date: May 8, 2024 3:24 PM
Number of letters in database: 6,218
Number of sequences in database: 16
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
