BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 318d4e2bbff69f6c5f3c9ceb40f31dc7.TrEMBL.fasta
19 sequences; 8,215 total letters
Query= ACIAD0644
Length=429
Score E
Sequences producing significant alignments: (Bits) Value
Q6FEE4 Dihydrofolate synthase/folylpolyglutamate synthase [Acinet... 841 0.0
A0A7G2SD04 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 838 0.0
A0A009YIZ3 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 676 0.0
N9C603 Dihydrofolate synthase/folylpolyglutamate synthase [Acinet... 675 0.0
A0A3A8ELI8 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 674 0.0
A0A427PQW3 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 674 0.0
A0A3R9BB53 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 673 0.0
A0A3G9G084 Dihydrofolate synthase/folylpolyglutamate synthase [Ac... 673 0.0
A0A6H0FQZ6 tetrahydrofolate synthase [Acinetobacter pittii] 663 0.0
G3XCM6 tetrahydrofolate synthase [Pseudomonas aeruginosa] 289 4e-97
Q50990 tetrahydrofolate synthase [Neisseria gonorrhoeae] 233 2e-75
Q8GJP1 tetrahydrofolate synthase [Lactococcus lactis subsp. cremo... 179 6e-55
Q84FV7 Dihydrofolate synthase/folylpolyglutamate synthase [Methyl... 166 1e-49
Q9X7F5 Dihydrofolate synthase/folylpolyglutamate synthase [Methyl... 163 2e-48
A0A0M4G2P0 Dihydrofolate synthase/folylpolyglutamate synthase [Ri... 158 5e-47
O08416 tetrahydrofolate synthase [Streptomyces coelicolor] 140 2e-40
Q5VAN8 Dihydrofolate synthase/folylpolyglutamate synthase [Rhizob... 140 3e-40
Q54614 tetrahydrofolate synthase [Streptococcus pneumoniae] 139 4e-40
Q2VIK1 Dihydrofolate synthetase [Pneumocystis carinii] 135 2e-38
>Q6FEE4 Dihydrofolate synthase/folylpolyglutamate synthase [Acinetobacter
baylyi (strain ATCC 33305 / BD413 / ADP1)]
Length=428
Score = 841 bits (2172), Expect = 0.0
Identities = 427/428 (99%), Positives = 428/428 (100%), Gaps = 0/428 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+KLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG
Sbjct 1 MKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL
Sbjct 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW
Sbjct 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN
Sbjct 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW
Sbjct 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV
Sbjct 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
Query 421 WEYLEKCQ 428
WEYLEKCQ
Sbjct 421 WEYLEKCQ 428
>A0A7G2SD04 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter sp]
Length=428
Score = 838 bits (2165), Expect = 0.0
Identities = 426/428 (99%), Positives = 427/428 (99%), Gaps = 0/428 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+KLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG
Sbjct 1 MKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL
Sbjct 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW
Sbjct 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN
Sbjct 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW
Sbjct 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEA
Sbjct 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAG 420
Query 421 WEYLEKCQ 428
WEYLEKCQ
Sbjct 421 WEYLEKCQ 428
>A0A009YIZ3 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter sp. 479375]
Length=428
Score = 676 bits (1745), Expect = 0.0
Identities = 334/428 (78%), Positives = 379/428 (89%), Gaps = 0/428 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+K DAP I D+L TWL YWGHVHVTGIDLGLERVIPVAE LGV Q AKVFTVAGTNGKG
Sbjct 1 MKPDAPKITDNLDTWLDYWGHVHVTGIDLGLERVIPVAEALGVMQPQAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASIL EQGY+VGLYQSPHIYRFNERVKL GQE DQ LI+AFV+VDQ RR+C L
Sbjct 61 STTTTLASILNEQGYQVGLYQSPHIYRFNERVKLKGQEVDDQTLIDAFVQVDQARRQCEL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAF+IF+Q+ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFVIFKQKQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
+IEKIAFEKAGI+R +IPVIF G+Q LPQAI +A A+LYV +DYFYQ A D +SW
Sbjct 181 SIEKIAFEKAGIMRPDIPVIFAGLQDLPQAIQTQADQVNAKLYVAQQDYFYQAAGDGQSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPL SLALENISTAVAA+L+SG+D+SQAA++SGI+KA LAGRFEQR+I N
Sbjct 241 NFASSGTTLKLPLSSLALENISTAVAAVLLSGLDISQAALSSGIKKAQLAGRFEQRVIAN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K V+FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV LK VL+W
Sbjct 301 KTVIFDAGHNAHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVERLKSTVLNW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
K+A L+VPRAAP++QL+DAL GE ++SI+EAF +ALE++ +QLILVCGSFHTLEAV
Sbjct 361 KIAPLNVPRAAPLSQLMDALQGETVHSFESIQEAFKLALEQTNNNQLILVCGSFHTLEAV 420
Query 421 WEYLEKCQ 428
WEYLE+CQ
Sbjct 421 WEYLEQCQ 428
>N9C603 Dihydrofolate synthase/folylpolyglutamate synthase [Acinetobacter
ursingii ANC 3649]
Length=425
Score = 675 bits (1742), Expect = 0.0
Identities = 335/425 (79%), Positives = 375/425 (88%), Gaps = 0/425 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+K DAP I DDL TWL YWGHVHVTGIDLGLERVIPVAE LGV Q AKVFTVAGTNGKG
Sbjct 1 MKPDAPKITDDLDTWLDYWGHVHVTGIDLGLERVIPVAEALGVMQPQAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASIL EQGY+VGLYQSPHIYRFNERVKL GQE DQ LI AFV+VDQ RR+C L
Sbjct 61 STTTTLASILNEQGYQVGLYQSPHIYRFNERVKLKGQEVDDQTLIHAFVEVDQARRQCEL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAF+IF+Q+ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFVIFKQKQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
TIEKIAFEKAGI+R +IPVIF G+Q LPQAI +A A+LYV +DYFYQ A D +SW
Sbjct 181 TIEKIAFEKAGIMRPDIPVIFAGLQDLPQAIQTQANQVNAKLYVAQQDYFYQAAGDGQSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPL SLALENISTAVAA+L+SG+D+SQAA++SGI+KA LAGRFEQR+I N
Sbjct 241 NFASSGTTLKLPLSSLALENISTAVAAVLLSGLDISQAALSSGIKKAQLAGRFEQRVIAN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K V+FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV LKP VL+W
Sbjct 301 KTVIFDAGHNAHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVERLKPTVLNW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
K+A L+VPRAAP+ QL+DAL GE ++SI+EAF +ALE++ +QLILVCGSFHTLEAV
Sbjct 361 KIAPLNVPRAAPLFQLMDALQGETVDSFESIQEAFKLALEQTNNNQLILVCGSFHTLEAV 420
Query 421 WEYLE 425
WEYLE
Sbjct 421 WEYLE 425
>A0A3A8ELI8 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter guerrae]
Length=428
Score = 674 bits (1738), Expect = 0.0
Identities = 334/428 (78%), Positives = 374/428 (87%), Gaps = 0/428 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+K DAP I DDL TWL YWGHVHVTGIDLGLERVIPVAE LGV Q AKVFTVAGTNGKG
Sbjct 1 MKPDAPKITDDLDTWLDYWGHVHVTGIDLGLERVIPVAEALGVMQPQAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASIL EQGY+VGLYQSPHIYRFNERVKL GQE DQ LIEAFV VDQ RR C L
Sbjct 61 STTTTLASILNEQGYQVGLYQSPHIYRFNERVKLKGQEVDDQTLIEAFVLVDQARRHCEL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAF+IF+Q+ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFVIFKQEQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
+IEKIAFEKAGIIR +IPVIF G+Q LPQAI KA A+LYV +DYFYQ D +SW
Sbjct 181 SIEKIAFEKAGIIRPDIPVIFAGLQDLPQAIQTKADQANAKLYVAQKDYFYQDVGDGQSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPL SLALENISTAVAA+L+S + +SQAA+ +GI+KA LAGRFEQR+I N
Sbjct 241 NFASSGTTLKLPLSSLALENISTAVAAVLLSDLVISQAALNNGIKKAQLAGRFEQRVIAN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K ++FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV LKP VL+W
Sbjct 301 KTIIFDAGHNAHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVERLKPTVLNW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
K+A L+VPRAAP++QL+DAL GE ++SI+EAF +ALE++ +QLILVCGSFHTLEAV
Sbjct 361 KIAPLNVPRAAPLSQLMDALQGETVHSFESIQEAFKLALEQANNNQLILVCGSFHTLEAV 420
Query 421 WEYLEKCQ 428
WEYLE+CQ
Sbjct 421 WEYLEQCQ 428
>A0A427PQW3 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter sp. FDAARGOS_515]
Length=425
Score = 674 bits (1738), Expect = 0.0
Identities = 333/425 (78%), Positives = 377/425 (89%), Gaps = 0/425 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+K DAP I D+L TWL YWGHVHVTGIDLGLERVIPVAE LGV Q AKVFTVAGTNGKG
Sbjct 1 MKPDAPKITDNLDTWLDYWGHVHVTGIDLGLERVIPVAEALGVMQPQAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTTTLASIL EQGY+VGLYQSPHIYRFNERVKL GQE DQ LI+AFV+VDQ RR+C L
Sbjct 61 STTTTLASILNEQGYQVGLYQSPHIYRFNERVKLKGQEVDDQTLIDAFVQVDQARRQCEL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAF+IF+Q+ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFVIFKQKQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
+IEKIAFEKAGI+R +IPVIF G+Q LPQAI +A A+LYV +DYFYQ A D +SW
Sbjct 181 SIEKIAFEKAGIMRPDIPVIFAGLQDLPQAIQTQADQVNAKLYVAQQDYFYQAAGDGQSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPL SLALENISTAVAA+L+SG+D+SQAA++SGI+KA LAGRFEQR+I N
Sbjct 241 NFASSGTTLKLPLSSLALENISTAVAAVLLSGLDISQAALSSGIKKAQLAGRFEQRVIAN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K V+FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV LKP VL+W
Sbjct 301 KTVIFDAGHNAHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVERLKPTVLNW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
K+A L+VPRAAP++QL+DAL GE ++SI+EAF +ALE++ +QLILVCGSFHTLEAV
Sbjct 361 KIAPLNVPRAAPLSQLMDALQGETVDSFESIQEAFKLALEQTNNNQLILVCGSFHTLEAV 420
Query 421 WEYLE 425
WEYLE
Sbjct 421 WEYLE 425
>A0A3R9BB53 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter soli]
Length=428
Score = 673 bits (1737), Expect = 0.0
Identities = 336/428 (79%), Positives = 373/428 (87%), Gaps = 0/428 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+KLDAP I DDLMTWLTYWGHVHVTGIDLGLERV+PVA+KLGVTQ SAK+FTVAGTNGKG
Sbjct 1 MKLDAPRINDDLMTWLTYWGHVHVTGIDLGLERVLPVAQKLGVTQPSAKIFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTT LASIL QGY+VGLYQSPHIYRFNERVKL GQEA+DQ+LIEAFV+VDQ RRECGL
Sbjct 61 STTTVLASILQAQGYKVGLYQSPHIYRFNERVKLAGQEATDQELIEAFVQVDQTRRECGL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAFLIFQ+QACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFLIFQKQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
TIEKIAFEKAGIIR IPV+FGG+QTLP AIA KAA +A L V RDYFYQ+A +W
Sbjct 181 TIEKIAFEKAGIIRPGIPVVFGGLQTLPDAIASKAAECRANLQVAQRDYFYQLAETPNTW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
FAS+G TL+LP GSLALENI+TAVAA+L+S + VSQ AI GI+ A L+GRFE R I+
Sbjct 241 QFASAGVTLQLPTGSLALENIATAVAAILMSDVIVSQDAICQGIQNAKLSGRFELRNIEQ 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K V+FDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDI VV+LLKP + W
Sbjct 301 KTVIFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDISTVVDLLKPVITSW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
VA L+ PRAA + L+ AL + TQ +DSI++AFS A+ + +PHQLILVCGSFHTLEAV
Sbjct 361 HVAPLNNPRAASLEHLMHALKDQTTQTFDSIQDAFSTAIAKVKPHQLILVCGSFHTLEAV 420
Query 421 WEYLEKCQ 428
WEYLE+CQ
Sbjct 421 WEYLEECQ 428
>A0A3G9G084 Dihydrofolate synthase/folylpolyglutamate synthase
[Acinetobacter ursingii]
Length=425
Score = 673 bits (1737), Expect = 0.0
Identities = 333/425 (78%), Positives = 376/425 (88%), Gaps = 0/425 (0%)
Query 1 LKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60
+K DAP I DDL TWL YWGHVHVTGIDLGLERVIPVAE LGV Q AKVFTVAGTNGKG
Sbjct 1 MKPDAPKITDDLDTWLDYWGHVHVTGIDLGLERVIPVAEALGVMQPQAKVFTVAGTNGKG 60
Query 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120
STTT LASIL EQGY+VGLYQSPHIYRFNERVKL GQE DQ LI+AFV+VDQ RR+C L
Sbjct 61 STTTALASILNEQGYQVGLYQSPHIYRFNERVKLKGQEVDDQTLIDAFVQVDQARRQCEL 120
Query 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180
SLSFFEATTLAAF+IF+Q+ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGD
Sbjct 121 SLSFFEATTLAAFVIFKQKQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGD 180
Query 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240
+IEKIAFEKAGIIR +IPVIF G+Q LPQAI +A A+LYV +DYFYQ A D +SW
Sbjct 181 SIEKIAFEKAGIIRPDIPVIFAGLQDLPQAIQTQANQVNAKLYVAQQDYFYQAAGDGQSW 240
Query 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300
NFASSGTTLKLPL SLALENISTAVAA+L+SG+D+SQAA++SGI++A LAGRFEQR+I N
Sbjct 241 NFASSGTTLKLPLSSLALENISTAVAAVLLSGLDISQAALSSGIKEAQLAGRFEQRVIAN 300
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
K V+FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV LKP VL+W
Sbjct 301 KTVIFDAGHNAHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVERLKPTVLNW 360
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420
K+A L+VPRAAP++QL+DAL GE ++SI+EAF +ALE++ +QLILVCGSFHTLEAV
Sbjct 361 KIAPLNVPRAAPLSQLMDALQGETVDSFESIQEAFKLALEQTNNNQLILVCGSFHTLEAV 420
Query 421 WEYLE 425
WEYLE
Sbjct 421 WEYLE 425
>A0A6H0FQZ6 tetrahydrofolate synthase [Acinetobacter pittii]
Length=428
Score = 663 bits (1710), Expect = 0.0
Identities = 325/424 (77%), Positives = 370/424 (87%), Gaps = 0/424 (0%)
Query 5 APSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTT 64
AP D L TWL YW HVHVTGIDLGLERVIPVAEKLGVTQ +AKVFTVAGTNGKGSTTT
Sbjct 5 APLSIDSLDTWLNYWSHVHVTGIDLGLERVIPVAEKLGVTQPNAKVFTVAGTNGKGSTTT 64
Query 65 TLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGLSLSF 124
TLA+IL QGY+VGLYQSPHIYRFNERVKL G EA DQ LI+AFV+VDQ RR+C LSLSF
Sbjct 65 TLAAILNAQGYKVGLYQSPHIYRFNERVKLGGVEADDQSLIDAFVQVDQARRDCDLSLSF 124
Query 125 FEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEK 184
FEATTLAAF+IF+QQ CD+WVLEVGLGGRLDVVNVIDPD+AVITNIGLDHTDWLGDTIEK
Sbjct 125 FEATTLAAFVIFKQQQCDVWVLEVGLGGRLDVVNVIDPDIAVITNIGLDHTDWLGDTIEK 184
Query 185 IAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNFAS 244
IAFEKAGIIR +IPVIF G Q LPQAI DKA + QA+LY + RDYFY++A D ++W FAS
Sbjct 185 IAFEKAGIIRPHIPVIFAGEQPLPQAIQDKAQSTQAELYTVNRDYFYKLADDGQNWYFAS 244
Query 245 SGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKNKAVV 304
GTTLKLPLG+LA+ENI+ AVAA+L SG+++SQ+A+ GI+ A LAGRFEQR + K V+
Sbjct 245 EGTTLKLPLGTLAIENIAGAVAAILNSGLEISQSALEKGIQSARLAGRFEQRQVDGKTVI 304
Query 305 FDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHWKVAA 364
FDAGHN HGV+FLLKQLRNFLEYNKQYTEV+AVFSMLADKDIK+VV+LLKP VLHWK+A
Sbjct 305 FDAGHNPHGVEFLLKQLRNFLEYNKQYTEVVAVFSMLADKDIKSVVDLLKPTVLHWKIAE 364
Query 365 LSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAVWEYL 424
L+VPRAAP+ QL DAL G+ QQY +I+EAF ALE++ +QLIL CGSFHTLEA+WEYL
Sbjct 365 LNVPRAAPIQQLNDALQGQTVQQYGNIKEAFKSALEQTNNNQLILACGSFHTLEAIWEYL 424
Query 425 EKCQ 428
E+CQ
Sbjct 425 EECQ 428
>G3XCM6 tetrahydrofolate synthase [Pseudomonas aeruginosa]
Length=429
Score = 289 bits (739), Expect = 4e-97
Identities = 174/431 (40%), Positives = 249/431 (58%), Gaps = 23/431 (5%)
Query 9 QDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLAS 68
Q L WL+Y +H T ID+GLER VA +LG+ + + +V TV GTNGKGST LA
Sbjct 3 QRSLADWLSYLEQLHPTAIDMGLERSREVARRLGLGRPAKRVVTVTGTNGKGSTCALLAE 62
Query 69 ILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGLSLSFFEAT 128
+L EQG VG+Y SPH+ R+NERV+++G EA D QL +AF V+ R E +SL++FE
Sbjct 63 LLREQGLSVGVYSSPHLLRYNERVRIDGIEAGDAQLCDAFSAVEAARGE--ISLTYFEMG 120
Query 129 TLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKIAFE 188
TLAAF +F++ D VLEVGLGGRLD VN+ID D+A+IT+IGLDH DWLGDT E +AFE
Sbjct 121 TLAAFWLFERAGLDFAVLEVGLGGRLDAVNLIDADLALITSIGLDHADWLGDTRESVAFE 180
Query 189 KAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW-NFASSGT 247
KAGI+R+ P + G + PQ + ++ AA A LY+ GRDY +A W A+ G
Sbjct 181 KAGILRAGKPALCGDLDP-PQPLLEQVAALGAPLYLRGRDYDLALADHGWHWRGLAADGQ 239
Query 248 TL---KLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRII----KN 300
L LPL L +EN + A+ A + + + + + + GR ++R + +
Sbjct 240 ALALHDLPLLGLPMENAALALQAYALLELPWQAERLAEALRRTRVTGRLDRRDLSWNGQP 299
Query 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360
+ ++ D GHN +L ++LR + +AVF +LADKD+ V+ L V W
Sbjct 300 RQLLLDVGHNPQAAQYLAQRLRAAAPRGR----YLAVFGLLADKDLDGVLEPLTGLVQDW 355
Query 361 KVAALSVPRAAPVTQLLDALDGEITQQ-----YDSIREAFSVALEESRPHQLILVCGSFH 415
VA L PR+ P +L AL I +Q + I A ++ +IL+ GSF+
Sbjct 356 AVAPLPTPRSRPAAELEAAL---ILRQVPASSHADIAAALDAQCAKATADDVILLFGSFY 412
Query 416 TLEAVWEYLEK 426
++ E+L +
Sbjct 413 SVAEGLEWLAR 423
>Q50990 tetrahydrofolate synthase [Neisseria gonorrhoeae]
Length=424
Score = 233 bits (594), Expect = 2e-75
Identities = 159/431 (37%), Positives = 226/431 (52%), Gaps = 28/431 (6%)
Query 12 LMTWLTYWGHVHVTG-IDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLASIL 70
L WL++ H G ID+GLERV V +++ +T V VAGTNGKGS L I
Sbjct 4 LQDWLSHLETAHSGGLIDMGLERVSEVKKRMNLTP-QCPVVVVAGTNGKGSVCAYLTQIY 62
Query 71 TEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGLSLSFFEATTL 130
+ G++ G SPH+ +NER+ +N + SD +I +F +++ R E +SL++FE L
Sbjct 63 KQAGFKTGTLTSPHLLHYNERIAINAEPVSDDTIIASFERIEAARGE--ISLTYFEFNAL 120
Query 131 AAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKIAFEKA 190
AA IF ++ D+ +LEVGLGGRLD VN D D AV+T++ LDH +LGDT+E++ FEKA
Sbjct 121 AAVDIFIREQVDVMILEVGLGGRLDAVNGFDGDCAVVTSVDLDHQAFLGDTVEQVGFEKA 180
Query 191 GIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNF-------- 242
G+ RS P I G P ++ A A A+L ++ RD+ + A + WN+
Sbjct 181 GVFRSGKPAIC-GQNPAPASLVAHAEAIGAKLLMVQRDFEFH-AMENIQWNYRFRPQHSD 238
Query 243 --ASSGTTLKLPL--GSLALENISTAVAAL--LVSGIDVSQAAITSGIEKAHLAGRFEQR 296
A + L P G+ L N + A+ L L + V AI G+ GRF Q
Sbjct 239 GPARNRNALPFPALRGAYQLSNAACALTVLECLDDRLPVDIGAIKRGLLLVENPGRF-QV 297
Query 297 IIKNKAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPA 356
+ V D GHN H L + L N L Y ++ T AVFSML+DKDI V +K
Sbjct 298 LPGRPLTVLDVGHNPHAARALRRNLIN-LAYAQKRT---AVFSMLSDKDIDGVSETVKDQ 353
Query 357 VLHWKVAALSVPRAAPVTQLLDALDG---EITQQYDSIREAFSVALEESRPHQLILVCGS 413
W +A L VPR L L+ E Q + ++R+A+ A ++ I+V GS
Sbjct 354 FDEWYIAPLDVPRGMTADALKAKLEQHHIENIQTFAAVRDAYRAAASKAGEDDRIVVFGS 413
Query 414 FHTLEAVWEYL 424
FHT+ V L
Sbjct 414 FHTVADVMSVL 424
>Q8GJP1 tetrahydrofolate synthase [Lactococcus lactis subsp. cremoris]
Length=427
Score = 179 bits (454), Expect = 6e-55
Identities = 136/414 (33%), Positives = 212/414 (51%), Gaps = 26/414 (6%)
Query 30 GLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLASILTEQGYRVGLYQSPHIYRFN 89
GL RV + E LG + S + +AGTNGKGST SI + G +V + SP I F
Sbjct 21 GLNRVSALLELLGNPEESLSMIHIAGTNGKGSTVAFTRSIFMQAGLKVASFTSPFITTFG 80
Query 90 ERVKLNGQEASDQQLIEAFVK-----VDQVRRECGLS-LSFFEATTLAAFLIFQQQACDI 143
ER+ +N Q D++LI +VK V+Q+ + L+ ++ FE T AF F + D+
Sbjct 81 ERMSINAQPIPDEKLIY-YVKMIQPLVEQLDNDAELTGITEFEIITAMAFKYFADEKVDL 139
Query 144 WVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIRSNIPVIFGG 203
V+EVGLGG LD NVI P V+ IT IGLDH D LG TIE+IA +KAGII++ IPV+ G
Sbjct 140 AVIEVGLGGLLDSTNVIRPVVSGITTIGLDHIDILGSTIEEIAAQKAGIIKAGIPVVVGN 199
Query 204 VQTLP-QAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNFASSGTTLKLP---LGSLALE 259
++ + I + A A++Y DY ++ + FA L L +G +E
Sbjct 200 IELKALRVIWEVARKNTARIYQYPYDYRTELKEHEHFDFFAGQEAILDLEKSLIGLHQVE 259
Query 260 NISTAVAALLV----SGIDVSQAAITSGIEKAHLAGRFEQRIIKNKAVVFDAGHNGHGVD 315
N A+ LV GI++++ I +GI +A R E ++ +N ++ D HN H ++
Sbjct 260 NAGMAIELALVYANKVGINLNEEIIRAGIREAFWPARME-KLGENPLILLDGAHNVHAMN 318
Query 316 FLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAV-LHWKVAALSVPRAAPVT 374
LL+ L K + +FS + KDI+ ++ +L+ + P+A +
Sbjct 319 RLLENLGKEFPDKK----ITIIFSAITTKDIRQMIKMLQTVKNSRLILTTFDYPKALDLK 374
Query 375 --QLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAVWEYLEK 426
+ L+ E+ ++ AL+E +L+L+ GS + V E+L+K
Sbjct 375 DFRYLEDEGVELAPSWELAIVRAQKALDED---ELLLITGSLYFSSQVREFLKK 425
>Q84FV7 Dihydrofolate synthase/folylpolyglutamate synthase [Methylorubrum
extorquens]
Length=441
Score = 166 bits (419), Expect = 1e-49
Identities = 132/431 (31%), Positives = 207/431 (48%), Gaps = 40/431 (9%)
Query 22 VHVTGIDLGLERVIPVAEKLGVTQTSAK-VFTVAGTNGKGSTTTTLASILTEQGYRVGLY 80
+H IDL L R+ + L + V VAGTNGKGST + +IL G +Y
Sbjct 14 LHPRTIDLSLGRIQRLLAALNHPERRLPPVIHVAGTNGKGSTIAFMRAILEAGGLAAHVY 73
Query 81 QSPHIYRFNERVKL----NGQEASDQQLIEAFVKVDQVRRECGLSLSFFEATTLAAFLIF 136
SPH+ RF+ER++L G ++ +L +AF + + + G ++ FE TT AA L+F
Sbjct 74 TSPHLVRFHERIRLGGIGGGHYVAEDRLADAFARCEAANK--GDPITVFEITTAAALLLF 131
Query 137 QQQACDIWVLEVGLGGRLDVVNVID-PDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIRS 195
+ D+ +LEVGLGGR+D NVID P AV+T IG DH ++LGDT+E +A EKAGI +
Sbjct 132 SECPADVLLLEVGLGGRVDATNVIDHPACAVVTPIGRDHAEYLGDTVEAVAMEKAGIFKR 191
Query 196 NIPVIFGGVQTLPQAIADKAAAQQAQ----LYVLGRDYFYQVAPDQKSWNFASSGTTLKL 251
P + + A AD +QA+ + V + + V + + + L
Sbjct 192 GCPAV---IAAQDYAGADAVLCRQAERIGAVPVRIGNQDFSVHEESGRFVYQDEIDLFDL 248
Query 252 PLGSLA----LENISTAVAALLVSGI-DVSQAAITSGIEKAHLAGRFE--------QRII 298
P LA L N TA+AAL +G D+ A+ +G+ GR + +R+
Sbjct 249 PRPRLAGRHQLTNAGTAIAALRAAGFGDIGTVALEAGLRNVDWPGRLQRLVRGALAERMP 308
Query 299 KNKAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKD----IKAVVNLLK 354
K+ + D GHN G L + + E + ++ + +L KD +K V L +
Sbjct 309 KDAELWLDGGHNADGGRILAAAMADLGE--RSDVPLVLIVGLLGTKDAEGFLKNFVGLAR 366
Query 355 PAV---LHWKVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVC 411
V + ++AA A + + + L E+ ++ A + + E P +L+C
Sbjct 367 SLVAVPITGQMAARPAEEVAEIAREV-GLSAEVAPSVEAALAALADTVFERPPR--VLIC 423
Query 412 GSFHTLEAVWE 422
GS + AV E
Sbjct 424 GSLYLAGAVLE 434
>Q9X7F5 Dihydrofolate synthase/folylpolyglutamate synthase [Methylorubrum
extorquens]
Length=467
Score = 163 bits (412), Expect = 2e-48
Identities = 136/420 (32%), Positives = 194/420 (46%), Gaps = 21/420 (5%)
Query 22 VHVTGIDLGLERVIPVAEKLGVTQ-TSAKVFTVAGTNGKGSTTTTLASILTEQGYRVGLY 80
+H ID L R+ + LG + V VAGTNGKGS + ++L G RV Y
Sbjct 36 LHTQEIDYSLHRMHRLLADLGSPERVLPPVIHVAGTNGKGSAIAVMRTLLEAGGLRVHTY 95
Query 81 QSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRREC--GLSLSFFEATTLAAFLIFQQ 138
SPH+ FNER++L AS + EC G ++ FE T AAF +F
Sbjct 96 TSPHLVHFNERIRLASINASRPVADDVLENALMYCLECNRGRPITQFEVVTAAAFHMFAT 155
Query 139 QACDIWVLEVGLGGRLDVVNVIDPDVA-VITNIGLDHTDWLGDTIEKIAFEKAGIIRSNI 197
D+ +LE GLGGR D NV+ VA VIT+I DH +LG +IE+IA EKAGI R I
Sbjct 156 HDADVVLLEAGLGGRCDATNVVPKPVATVITSISYDHETYLGSSIEQIAVEKAGIFRPGI 215
Query 198 PVIFGGVQ--TLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNFASSGTTLKLP--L 253
PVI G Q I+ A+ A ++ GRD+ +V D+ + + + LP
Sbjct 216 PVIVGPQQYFVAENVISRAASLIGAPIHKAGRDFRGKVRGDKFVYIDSEGLHSWPLPGLA 275
Query 254 GSLALENISTAVAALLVSGIDVSQAAITSGIEKAH-------LAGRFEQRIIKNKAVVFD 306
G ++N STA+A LL +G+ A + + L GR + + + VV D
Sbjct 276 GEHQIDNSSTAIATLLTTGLMPDSATVRRALPLVRWPGRLQPLTGRVAEMLPPDTDVVVD 335
Query 307 AGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHWKVAALS 366
GHN + +LR E +++ T + + MLA KD A + +V L
Sbjct 336 GGHNPGAAAVIASELRRRNETDQRST--VLILGMLATKDAAAFLAPFLGSVFRVVTVPLR 393
Query 367 VPRAAPVTQLLDALDGEI---TQQYDSIREAFSVALEESRPHQL-ILVCGSFHTLEAVWE 422
+ Q L A+ G+I S+ EA + A + +L +L GS H V E
Sbjct 394 PDLISHDPQTLAAIAGDIGLSGHAASSVTEAIAEAGRLTSTLKLRLLFIGSLHLAGEVLE 453
>A0A0M4G2P0 Dihydrofolate synthase/folylpolyglutamate synthase
[Rickettsia endosymbiont of Ixodes pacificus]
Length=426
Score = 158 bits (399), Expect = 5e-47
Identities = 113/365 (31%), Positives = 181/365 (50%), Gaps = 24/365 (7%)
Query 50 VFTVAGTNGKGSTTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFV 109
V +AGTNGKGS+T L SI GY+V Y SPH+ FNER+ + G++ SD +L +
Sbjct 39 VIHIAGTNGKGSSTAMLKSIFMLAGYKVHCYTSPHLLEFNERIVVAGEKISDNELWQVCE 98
Query 110 KVDQVRRECGLSLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVID-PDVAVIT 168
+V + + SFFE TT AAFL F++ DI +LE GLGGRLD N+++ P + +IT
Sbjct 99 QVRVASEKFNIEPSFFEGTTAAAFLAFEKTKADILILETGLGGRLDATNIVERPLITLIT 158
Query 169 NIGLDHTDWLGDTIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRD 228
I DH + LG+T+ IA EKAGI++S +P + +Q L A A++ ++ +
Sbjct 159 PISYDHMNMLGNTLPLIAIEKAGIMKSCVPCVI-SMQALEVYETLFAKAEELEVPSFCYE 217
Query 229 YFYQVAPDQKSWNFASSGTTLKLP----LGSLALENISTAVA--ALLVSGIDVSQAAITS 282
Y + + ++S + + P LG L N ++ +A +L+ ++S I+
Sbjct 218 YDSGIKKTDNGFIYSSRNFSYEFPTPSLLGGHQLINAASVIALISLINKQFNISNEIISK 277
Query 283 GIEKAHLAGRFE--------QRIIKNKAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEV 334
G++ R E + I N + DA HN G L +R+ L+ + +
Sbjct 278 GLQNTIWGARIEKIEPKKYSKLIGDNVQIWVDAAHNNSGAQVLANWIRDNLK-----SPI 332
Query 335 IAVFSMLADKDIKAVVNLLKPAVLH-WKVAALSVP--RAAPVTQLLDALDGEITQQYDSI 391
+ M +++I+ + K + + V LS P +A L G + DS+
Sbjct 333 YLILGMTKNRNIEEFCSYFKGLTIKGYGVKVLSEPLSHSAETINLEGRKSGIDFSESDSL 392
Query 392 REAFS 396
EA S
Sbjct 393 EEAIS 397
>O08416 tetrahydrofolate synthase [Streptomyces coelicolor]
Length=444
Score = 140 bits (354), Expect = 2e-40
Identities = 115/377 (31%), Positives = 170/377 (45%), Gaps = 27/377 (7%)
Query 19 WGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLASILTEQGYRVG 78
WG T ++ + R+ + + LG Q S + GTNGK ST + ++L R G
Sbjct 16 WGE---TKLEPSVTRIAALMDVLGEPQRSYPSIHITGTNGKTSTARMIEALLGAFDLRTG 72
Query 79 LYQSPHIYRFNERVKLNGQEASDQQLIEAFVK----VDQVRRECGLSLSFFEATTLAAFL 134
Y SPH+ ER+ L+G S ++ IE + V+ V + SFFE T A+
Sbjct 73 RYTSPHVQSITERISLDGAPISAERFIETYEDIKPYVEMVDAQRSTGCSFFEVLTGMAYA 132
Query 135 IFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIR 194
F D+ V+EVG+GG D NVID DVAV+T I LDHTD LG T +IA EKAGI++
Sbjct 133 AFADAPVDVAVVEVGMGGSWDATNVIDGDVAVVTPIDLDHTDRLGGTPGEIAVEKAGIVK 192
Query 195 SNIPVIFGGVQT-LPQAIADKAAAQQAQLYVLGRDY--FYQVAPDQKSW----NFASSGT 247
+ VI Q + KA A + G ++ + P SW T
Sbjct 193 QDATVILAQQPVDAAQVMLKKAVDVNATVAREGLEFGVVAREVPSAGSWPPCAGLGGEYT 252
Query 248 TLKLPL-GSLALENISTAVAAL---LVSGIDVSQAAITSGIEKAHLA----GRFEQRIIK 299
+ LPL G+ N + A+AA+ G + + KA + GR E + +
Sbjct 253 EVYLPLHGAHQAHNAAVALAAVEAFFGVGAQRPEPLDVDTVRKAFASVASPGRMEV-VRR 311
Query 300 NKAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLH 359
+ VV DA HN G + + Q++ +I V ADK+++ ++ +P
Sbjct 312 SPTVVLDAAHNPAGARVTAEAVGEAF----QFSRLIGVVGASADKNVRGLLEAFEPVFAE 367
Query 360 WKVAALSVPRAAPVTQL 376
V S RA +L
Sbjct 368 VVVTQNSSHRAMDADEL 384
>Q5VAN8 Dihydrofolate synthase/folylpolyglutamate synthase [Rhizobium
etli]
Length=450
Score = 140 bits (353), Expect = 3e-40
Identities = 104/344 (30%), Positives = 165/344 (48%), Gaps = 25/344 (7%)
Query 22 VHVTGIDLGLERVIPVAEKLGVTQTSAK-VFTVAGTNGKGSTTTTLASILTEQGYRVGLY 80
+H G DL L+R+ + ++LG V VAGTNGKGS T ++L GY ++
Sbjct 22 LHPKGFDLSLDRITRLLDRLGNPHRKLPPVVHVAGTNGKGSVTAFCRALLEAGGYSAHVH 81
Query 81 QSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRR----ECGLSLSFFEATTLAAFLIF 136
SPH+ ++ER ++ G QL++ V + VRR G ++ FE T F++F
Sbjct 82 TSPHLVNWHERYRI-GVAGGRGQLVDDAVFAEAVRRVAEANAGQHITVFEILTAVTFILF 140
Query 137 QQQACDIWVLEVGLGGRLDVVNVI-DPDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIRS 195
+ D ++EVGLGGR D NVI DP V+VI I LDH +LGD +E IA EKAGI++
Sbjct 141 SEHPADAAIIEVGLGGRFDATNVISDPAVSVIMPISLDHQPYLGDRVELIAAEKAGIMKP 200
Query 196 NIPVIFGGVQTLPQAIADKAAAQQAQLY----VLGRDYFYQVAPDQKSWNFASSGTTLKL 251
+PV+ G + A D + +L+ V G+D+ + + L L
Sbjct 201 GLPVVIGHQEY--DAALDVLMSTAERLHCPSAVFGQDFMAHEEYGRLVYQDEYGLADLPL 258
Query 252 PL--GSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRF----EQRIIKN----K 301
P G N + A+ A+ +G V++ + + GR E R++ +
Sbjct 259 PRLPGRHQYANAAAAIRAVKAAGFTVTETMMEKAMNCVEWPGRLQRLSEGRLLSHAPLGA 318
Query 302 AVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKD 345
+ D GHN + + + + +F E +Q + + M+ KD
Sbjct 319 EIWVDGGHNPGAGEVIAEAMASFEE--RQPRPLFLIIGMINTKD 360
>Q54614 tetrahydrofolate synthase [Streptococcus pneumoniae]
Length=440
Score = 139 bits (351), Expect = 4e-40
Identities = 104/342 (30%), Positives = 174/342 (51%), Gaps = 25/342 (7%)
Query 30 GLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLASILTEQGYRVGLYQSPHIYRFN 89
GLER++ + G KV + GTNGKGST L +L + G RVG++ SP++ +
Sbjct 21 GLERMVELLALRGNPHLKLKVLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYT 80
Query 90 ERVKLNGQEASDQQLIEAFVKVDQ--VRRECGLSL---SFFEATTLAAFLIFQQQACDIW 144
+++ +NG+ S+ +L EA + Q + E +L + FE T A+ F + D+
Sbjct 81 DQISINGESISEARL-EALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVA 139
Query 145 VLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIRSNIPVIFGGV 204
++EVG+GG D NV P + IT IGLDH LGDT+E IA +KAGII+ +P++ G +
Sbjct 140 IMEVGMGGLFDSTNVCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRI 199
Query 205 QTLPQAIADK-AAAQQAQLYVLGRDY---FYQVAPDQKSWNFASS---GTTLKLPLGSLA 257
A+ D+ A + A G DY + + +++ S+ G LG
Sbjct 200 APEALAVIDRIAEGKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQ 259
Query 258 LENISTAVAAL----LVSGIDV-SQAAITSGIEKAHLAGRFEQRIIKNKAVVFDAGHNGH 312
+EN A+A L G ++ S + +E+ GR E + ++ ++ D HN H
Sbjct 260 IENAGMAIALLDTFCQEDGRELASNDFLGQALEETSWPGRLE-IVSRDPLMILDGAHNPH 318
Query 313 GVDFLLKQLR-NFLEYNKQYTEVIAVFSMLADKDIKAVVNLL 353
+ LL L+ F +Y+K+ +F+ + K ++ +++LL
Sbjct 319 AIKALLVTLQERFADYHKE-----ILFTCIKTKALEDMLDLL 355
>Q2VIK1 Dihydrofolate synthetase [Pneumocystis carinii]
Length=424
Score = 135 bits (339), Expect = 2e-38
Identities = 114/419 (27%), Positives = 196/419 (47%), Gaps = 26/419 (6%)
Query 27 IDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTTLASILTEQGYRVGLYQSPHIY 86
+ LGL R+ + + LG Q S + VAGTNGKGS L+S L G RVG Y SPH+
Sbjct 3 VKLGLLRIRQLLKYLGNPQNSFQAVHVAGTNGKGSVCAYLSSCLALSGIRVGQYCSPHLI 62
Query 87 RFNERVKLNGQEASDQQLIEAFVKVDQVRRECGLSLSFFEATTLAAFLIFQQQACDIWVL 146
+ VK+ G++ Q +E K+ + + C + + FE T AF I + ++ V+
Sbjct 63 DRWDCVKVIGRDIDKHQFLEIESKIKNLNQRCNIGATEFEIMTAVAFEILSKNNVELAVI 122
Query 147 EVGLGGRLDVVNVIDPD-VAVITNIGLDHTDWLGDTIEKIAFEKAGIIRSNIPVIFGG-- 203
E G+GGRLD NV+ + +IT I +DH + LG+TI+KIA EK+GI++ NIP I G
Sbjct 123 ETGVGGRLDATNVLSQVLLTIITKISMDHQELLGNTIQKIAREKSGIMKKNIPCIVDGTN 182
Query 204 ---VQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNFASSGTTLKLPLGSLALEN 260
V + + + K+ + + L + D + + W T+L L
Sbjct 183 EDSVLKVIKEESIKSGSSRVILTPMDLDKSLYI----QEWKKHEFKTSLYRTYQRTNLAC 238
Query 261 ISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFE-----QRIIKNKAVVFDAGHNGHGVD 315
+S ++ L ++ ++ G+ + + GR E Q ++ D HN G++
Sbjct 239 VSASLEILSKYYPKITPDILSKGLLETYWPGRLEWIDLSQIAFGANKILLDGAHNIDGIN 298
Query 316 FLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVN-LLKPAVLHWKVAALSVPRAAPVT 374
L + + N + Q + F+ KD+ ++++ LLKP V V +
Sbjct 299 SLSEYI-NSIRNGVQSVSWLTAFTQ--GKDVDSLLSILLKPYDKIHSVEFEPVDGMQWIK 355
Query 375 QLLDALDGEITQQY---DSIR----EAFSVALEESRPHQLILVCGSFHTLEAVWEYLEK 426
+ + +I ++Y ++++ + S S+ L ++CGS + + V L K
Sbjct 356 PVNSSEIAKIARKYLYEENVKQHGTDLLSAIRSISQDKGLQVICGSLYLIGQVHRLLHK 414
Lambda K H a alpha
0.322 0.136 0.399 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 2724579
Database: 318d4e2bbff69f6c5f3c9ceb40f31dc7.TrEMBL.fasta
Posted date: May 9, 2024 8:43 PM
Number of letters in database: 8,215
Number of sequences in database: 19
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
Loading
Data ...
