BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: b7022d79209420ab5c0323ef637face3.SwissProt.fasta
20 sequences; 5,538 total letters
Query= ACIAD0715
Length=220
Score E
Sequences producing significant alignments: (Bits) Value
Q87LD3 Dual-specificity RNA pseudouridine synthase RluA [Vibrio p... 202 8e-69
Q8DCG0 Dual-specificity RNA pseudouridine synthase RluA [Vibrio v... 202 8e-69
P0AA38 Dual-specificity RNA pseudouridine synthase RluA [Shigella... 194 5e-66
P0AA37 Dual-specificity RNA pseudouridine synthase RluA [Escheric... 194 5e-66
Q8FL93 Dual-specificity RNA pseudouridine synthase RluA [Escheric... 194 5e-66
Q8XA10 Dual-specificity RNA pseudouridine synthase RluA [Escheric... 194 7e-66
Q9CK02 Dual-specificity RNA pseudouridine synthase RluA [Pasteure... 190 2e-64
Q8ZRV9 Dual-specificity RNA pseudouridine synthase RluA [Salmonel... 186 7e-63
Q8Z9J5 Dual-specificity RNA pseudouridine synthase RluA [Salmonel... 186 1e-62
Q9KP71 Dual-specificity RNA pseudouridine synthase RluA [Vibrio c... 183 2e-61
Q8ZIK1 Dual-specificity RNA pseudouridine synthase RluA [Yersinia... 177 1e-59
Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 [Chlo... 120 2e-36
P50513 Ribosomal large subunit pseudouridine synthase D [Zymomona... 113 2e-33
P33643 Ribosomal large subunit pseudouridine synthase D [Escheric... 112 4e-33
P33640 Ribosomal large subunit pseudouridine synthase D [Pseudomo... 112 5e-33
Q9L7A7 Ribosomal large subunit pseudouridine synthase D [Haemophi... 112 6e-33
P65836 Ribosomal large subunit pseudouridine synthase D [Salmonel... 110 2e-32
P0AA39 Ribosomal large subunit pseudouridine synthase C [Escheric... 98.6 6e-28
P0AA41 tRNA pseudouridine synthase C [Escherichia coli (strain K12)] 92.4 5e-26
Q8IZ73 Pseudouridylate synthase RPUSD2 [Homo sapiens] 94.4 1e-25
>Q87LD3 Dual-specificity RNA pseudouridine synthase RluA [Vibrio
parahaemolyticus serotype O3:K6 (strain RIMD 2210633)]
Length=250
Score = 202 bits (514), Expect = 8e-69
Identities = 104/204 (51%), Positives = 139/204 (68%), Gaps = 5/204 (2%)
Query 7 YMPPQDPMC-MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PP DP +V+EDD ++ ++KP+GLLSV GRL EH DS + R++++YP +V HRLDM
Sbjct 6 YNPPTDPWTDIVFEDDHILAVNKPSGLLSVPGRLAEHHDSMWSRLQEEYPDIQVVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEV-QAQGMVEAPLITDWPNRPKQ 124
+TSGL++ AK++RAE A+ K FQ R K Y A V G V Q +G ++ PLI DWPNRP Q
Sbjct 66 STSGLMVLAKNKRAESALKKQFQFRLTHKIYYARVWGHVEQEEGEIDLPLICDWPNRPLQ 125
Query 125 KIDFVEGKAAKTCYQPL---DYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLY 181
K+ F +GK +KT +Q + T ++L PITGRSHQLRVHMQ +GHPI+GD+ Y
Sbjct 126 KVCFEDGKPSKTLFQVAKREEQEDGTKTTIVRLLPITGRSHQLRVHMQALGHPIVGDEFY 185
Query 182 HPEPAKFALKRMALHATSLKFIQP 205
E AK +R+ LHA+ L F P
Sbjct 186 ATEEAKVFSERLELHASELSFYHP 209
>Q8DCG0 Dual-specificity RNA pseudouridine synthase RluA [Vibrio
vulnificus (strain CMCP6)]
Length=250
Score = 202 bits (514), Expect = 8e-69
Identities = 103/204 (50%), Positives = 138/204 (68%), Gaps = 5/204 (2%)
Query 7 YMPPQDPMC-MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y+PP DP +++EDD ++ ++KP+GLLSV GRLPEH DS + R+++QYP +V HRLDM
Sbjct 6 YLPPTDPWTEIIFEDDHILAVNKPSGLLSVPGRLPEHHDSMWSRLQEQYPEIQVVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQA-QGMVEAPLITDWPNRPKQ 124
+TSGL++FAK++RAE A+ K FQ R K Y A V G V+A GM++ PLI DWPNRP Q
Sbjct 66 STSGLMVFAKNKRAEAALKKQFQYRLTHKVYYARVWGHVEADSGMIDLPLICDWPNRPMQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFN---QTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLY 181
K+ GK ++T +Q N T ++L P+TGRSHQLRVHMQ +GHPI+GD+ Y
Sbjct 126 KVCHEHGKPSQTAFQVAKREVHANGAQTTIMRLLPVTGRSHQLRVHMQALGHPIVGDEFY 185
Query 182 HPEPAKFALKRMALHATSLKFIQP 205
A +R+ LHA L F P
Sbjct 186 AQGDAFTFSERLELHAAELSFYHP 209
>P0AA38 Dual-specificity RNA pseudouridine synthase RluA [Shigella
flexneri]
Length=219
Score = 194 bits (493), Expect = 5e-66
Identities = 100/201 (50%), Positives = 138/201 (69%), Gaps = 3/201 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P + ++Y+DD ++V++KP+GLLSV GRL EH+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+A V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y+ ++Y AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A+ R+ LHA L P
Sbjct 185 EARAMAPRLLLHAEMLTITHP 205
>P0AA37 Dual-specificity RNA pseudouridine synthase RluA [Escherichia
coli (strain K12)]
Length=219
Score = 194 bits (493), Expect = 5e-66
Identities = 100/201 (50%), Positives = 138/201 (69%), Gaps = 3/201 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P + ++Y+DD ++V++KP+GLLSV GRL EH+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+A V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y+ ++Y AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A+ R+ LHA L P
Sbjct 185 EARAMAPRLLLHAEMLTITHP 205
>Q8FL93 Dual-specificity RNA pseudouridine synthase RluA [Escherichia
coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=219
Score = 194 bits (493), Expect = 5e-66
Identities = 101/201 (50%), Positives = 137/201 (68%), Gaps = 3/201 (1%)
Query 7 YMPPQDPMCMV-YEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P +V Y+DD ++V++KP+GLLSV GRL EH+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVVLYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+A V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y+ ++Y AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A+ R+ LHA L P
Sbjct 185 EARAMAPRLLLHAEMLTITHP 205
>Q8XA10 Dual-specificity RNA pseudouridine synthase RluA [Escherichia
coli O157:H7]
Length=219
Score = 194 bits (492), Expect = 7e-66
Identities = 99/201 (49%), Positives = 137/201 (68%), Gaps = 3/201 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P + ++Y+DD ++V++KP+GLLSV GRL EH+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+ V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFRERVPKKQYVTRVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y+ ++Y AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A+ R+ LHA L P
Sbjct 185 EARAMAPRLLLHAEMLTITHP 205
>Q9CK02 Dual-specificity RNA pseudouridine synthase RluA [Pasteurella
multocida (strain Pm70)]
Length=219
Score = 190 bits (482), Expect = 2e-64
Identities = 104/215 (48%), Positives = 137/215 (64%), Gaps = 3/215 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PP DP + +V+ DD +VI+KP+GLLSV G P++ DSA R++++Y HRLDM
Sbjct 6 YTPPTDPYLDIVHYDDHFVVINKPSGLLSVPGNQPQYYDSAMSRVKEKYGFCEPAHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQA-QGMVEAPLITDWPNRPKQ 124
+TSGL++FA + A+ + + F+ R +K+Y ALV G ++ QG V PLI DW NRP+Q
Sbjct 66 STSGLILFALSKVADRELKRQFREREPKKHYQALVWGHLEEDQGEVNLPLICDWENRPRQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
KI F GK A T Y+ L N TR++L PITGRSHQLR+HM +GHPI+GDK Y P
Sbjct 126 KICFERGKPALTLYEVL-ARYPNNTTRVKLTPITGRSHQLRLHMLALGHPILGDKFYAPP 184
Query 185 PAKFALKRMALHATSLKFIQPFTQQPLDIVATVPF 219
AK R+ LHA L F P TQ+ L A F
Sbjct 185 QAKALSPRLCLHAEQLAFRHPITQEWLSFSAPPAF 219
>Q8ZRV9 Dual-specificity RNA pseudouridine synthase RluA [Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=219
Score = 186 bits (472), Expect = 7e-63
Identities = 97/201 (48%), Positives = 135/201 (67%), Gaps = 3/201 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P + ++Y+D+ ++V++KP+GLLSV GRL H+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVILYQDEHIMVVNKPSGLLSVPGRLEAHKDSIMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+A V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y +++ AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYNVVEF-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A R+ LHA L P
Sbjct 185 EALSLAPRLQLHAEMLTITHP 205
>Q8Z9J5 Dual-specificity RNA pseudouridine synthase RluA [Salmonella
typhi]
Length=219
Score = 186 bits (471), Expect = 1e-62
Identities = 97/201 (48%), Positives = 135/201 (67%), Gaps = 3/201 (1%)
Query 7 YMPPQDP-MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PPQ+P + ++Y+D+ ++V++KP+GLLSV GRL H+DS RI++ YP A HRLDM
Sbjct 6 YNPPQEPWLVILYQDEHIMVVNKPSGLLSVPGRLEAHKDSIMTRIQRDYPQAESVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQ-AQGMVEAPLITDWPNRPKQ 124
ATSG+++ A + AE + + F+ R +K Y+A V G A+G+V+ PLI DWPNRPKQ
Sbjct 66 ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ + GK A+T Y +++ AA N R+ L+PITGRSHQLRVHM +GHPI+GD+ Y
Sbjct 126 KVCYETGKPAQTEYNVVEF-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDQFYASP 184
Query 185 PAKFALKRMALHATSLKFIQP 205
A R+ LHA L P
Sbjct 185 EALSLAPRLQLHAEMLTITHP 205
>Q9KP71 Dual-specificity RNA pseudouridine synthase RluA [Vibrio
cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)]
Length=245
Score = 183 bits (465), Expect = 2e-61
Identities = 101/201 (50%), Positives = 127/201 (63%), Gaps = 4/201 (2%)
Query 7 YMPPQDPMC-MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDM 65
Y PP+DP ++YED+ +I +KP+GLLSV GR EH DS + R+ P +V HRLDM
Sbjct 6 YNPPKDPWIDVIYEDEHIIAANKPSGLLSVPGRPVEHYDSMWARLVDYCPDVKVVHRLDM 65
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEV-QAQGMVEAPLITDWPNRPKQ 124
+TSGL++FAK + E A+ K FQ R K Y A V G + Q +G V PL DWPNRPKQ
Sbjct 66 STSGLILFAKGKHMESALKKQFQYRLTHKIYYARVWGVMEQNEGEVNLPLCCDWPNRPKQ 125
Query 125 KIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE 184
K+ F EG+ + T YQ + T ++L PITGRSHQLRVHMQ +GHPI+GD LY P
Sbjct 126 KVCFEEGRDSLTRYQVVKREE--KTTVVRLIPITGRSHQLRVHMQSLGHPIVGDDLYAPP 183
Query 185 PAKFALKRMALHATSLKFIQP 205
A R+ LHA L F P
Sbjct 184 EAVEFADRLQLHAAELCFYHP 204
>Q8ZIK1 Dual-specificity RNA pseudouridine synthase RluA [Yersinia
pestis]
Length=206
Score = 177 bits (450), Expect = 1e-59
Identities = 96/208 (46%), Positives = 134/208 (64%), Gaps = 4/208 (2%)
Query 14 MCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDMATSGLLMF 73
M ++Y+D ++V++KP+GLLSV GR PE++DS R++ +P A HRLDMATSG+++
Sbjct 1 MIVLYQDKHIMVVNKPSGLLSVPGRAPENKDSVMTRVQNDFPTAESVHRLDMATSGVIVV 60
Query 74 AKHRRAEIAISKLFQTRCIQKYYIALVDGEV-QAQGMVEAPLITDWPNRPKQKIDFVEGK 132
A + AE + + F+ R +K YIA V G + Q +G+++ PLI DWPNRPKQK+ + GK
Sbjct 61 ALTKAAERELKRQFREREPKKTYIARVWGHLAQDEGLIDLPLICDWPNRPKQKVCYETGK 120
Query 133 AAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLY-HPEPAKFALK 191
+A+T YQ + + TR++L PITGRSHQLRVHM +GHPI+GD Y HPE AK
Sbjct 121 SAQTEYQVISRDDD-GSTRVKLSPITGRSHQLRVHMLAMGHPILGDGFYAHPE-AKAMAS 178
Query 192 RMALHATSLKFIQPFTQQPLDIVATVPF 219
R+ LHA L P P+ F
Sbjct 179 RLQLHAQQLCITHPEFGTPMHFKCEAEF 206
>Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 [Chloroflexus
aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)]
Length=316
Score = 120 bits (302), Expect = 2e-36
Identities = 76/215 (35%), Positives = 120/215 (56%), Gaps = 14/215 (7%)
Query 13 PMCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLR-IRQQYP--------LARVTHRL 63
P+ +VYED D+ VI+KPAG+ V+ P H + + +YP + HRL
Sbjct 90 PLDVVYEDADIAVINKPAGM--VVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHRL 147
Query 64 DMATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWPNRPK 123
D TSGLL+ A+H +A ++ Q R ++K Y ALV G G ++AP+ D +R +
Sbjct 148 DRDTSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRPPETGTIDAPIGRDPRDRLR 207
Query 124 QKIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHP 183
+ +G+ A+T Y+ LD ++ +QLE TGR+HQ+RVH++H+G+PI+GD +Y P
Sbjct 208 MAV-VPDGRPARTHYRLLDTFGDYSLLEVQLE--TGRTHQIRVHLRHLGYPIVGDPVYGP 264
Query 184 EPAKFALKRMALHATSLKFIQPFTQQPLDIVATVP 218
+ L R LHA L + P + + + A +P
Sbjct 265 RRSHLHLSRQFLHAAYLGLVHPRSGRWQEFTAPLP 299
>P50513 Ribosomal large subunit pseudouridine synthase D [Zymomonas
mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)]
Length=317
Score = 113 bits (282), Expect = 2e-33
Identities = 83/229 (36%), Positives = 120/229 (52%), Gaps = 24/229 (10%)
Query 10 PQD-PMCMVYEDDDLIVIDKPAGLL--SVMGRLPEHQDSAYL-----RIRQQYPLAR--V 59
PQD P+ +V+ED+ L+V++KPAG++ G +A L ++ +AR +
Sbjct 77 PQDIPLEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVARPGI 136
Query 60 THRLDMATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWP 119
HR+D TSGLL+ AK A ++ F I + Y A+VDG QG V+APL
Sbjct 137 VHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPSLQGHVDAPLARSSV 196
Query 120 NRPKQKI-DFVEGKAAKTCYQPLD--YNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIM 176
NR K I GK A T Y+ + NA+ + R++ TGR+HQ+RVHM IGH ++
Sbjct 197 NRQKMAIVSDGRGKRAVTHYRMITPLKNASLIECRLE----TGRTHQVRVHMSSIGHSLL 252
Query 177 GDKLY-------HPEPAKFALKRMALHATSLKFIQPFTQQPLDIVATVP 218
GD +Y H A +R ALHA L FI P + + +D A +P
Sbjct 253 GDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDAEMP 301
>P33643 Ribosomal large subunit pseudouridine synthase D [Escherichia
coli (strain K12)]
Length=326
Score = 112 bits (280), Expect = 4e-33
Identities = 80/229 (35%), Positives = 118/229 (52%), Gaps = 25/229 (11%)
Query 10 PQD-PMCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQY-------PLARVTH 61
PQD P+ +VYED+D+I+I+KP L+ G + D L Y P A + H
Sbjct 79 PQDIPLDIVYEDEDIIIINKPRDLVVHPGA--GNPDGTVLNALLHYYPPIADVPRAGIVH 136
Query 62 RLDMATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWPNR 121
RLD T+GL++ AK A+ + + Q R I + Y A+ G + A G V+ P I+ P +
Sbjct 137 RLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEP-ISRHPTK 195
Query 122 PKQKIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLY 181
GK A T Y+ +++ + R++LE TGR+HQ+RVHM HI HP++GD +Y
Sbjct 196 RTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLE--TGRTHQIRVHMAHITHPLVGDPVY 253
Query 182 --HPEPAKFA----------LKRMALHATSLKFIQPFTQQPLDIVATVP 218
P P K A R ALHAT L+ P + ++ A +P
Sbjct 254 GGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIP 302
>P33640 Ribosomal large subunit pseudouridine synthase D [Pseudomonas
aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116
/ JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)]
Length=320
Score = 112 bits (279), Expect = 5e-33
Identities = 77/211 (36%), Positives = 109/211 (52%), Gaps = 24/211 (11%)
Query 16 MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQY-------PLARVTHRLDMATS 68
+VYED+ ++VIDKPAGL V+ HQD L + P A + HRLD T+
Sbjct 85 IVYEDEHILVIDKPAGL--VVHPAAGHQDGTLLNALLYHVPDIANVPRAGIVHRLDKDTT 142
Query 69 GLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWPNRPKQKIDF 128
GL++ AK A + Q R + + Y A+V G + + G ++AP+ R K +
Sbjct 143 GLMVVAKTLEAHTKLVAQLQARSVSRIYEAIVIGVITSGGTIDAPIGRHGVQRQKMAV-V 201
Query 129 VEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYH-----P 183
GK A + Y+ L+ A TR++LE TGR+HQ+RVHM HIG+P++GD +Y P
Sbjct 202 DAGKVAVSHYRVLERFRAHTHTRVKLE--TGRTHQIRVHMSHIGYPLVGDPVYGGRFRIP 259
Query 184 EPAKFAL-------KRMALHATSLKFIQPFT 207
A L R ALHA L+ P T
Sbjct 260 PVASQTLVQTLREFPRQALHARFLELDHPAT 290
>Q9L7A7 Ribosomal large subunit pseudouridine synthase D [Haemophilus
ducreyi (strain 35000HP / ATCC 700724)]
Length=325
Score = 112 bits (279), Expect = 6e-33
Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 24/231 (10%)
Query 7 YMPPQDPMCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQY-------PLARV 59
+ P P+ +V+EDDD+I+I+KP L+ G + D L Y P A +
Sbjct 77 FEPQNIPLNIVHEDDDIIIINKPKNLVVHPGA--GNPDGTVLNALLYYYPPIAEVPRAGI 134
Query 60 THRLDMATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWP 119
HRLD T+GL++ AK+ A+ + Q R I + Y A+ G + G V+ P+
Sbjct 135 IHRLDKDTTGLMVVAKNIPAQTHLVTALQKRRITREYEAIASGIMTQGGKVDEPMARHPT 194
Query 120 NRPKQKIDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDK 179
R + + GK A T Y+ ++ + + R++LE TGR+HQ+RVHM HI HP++GD+
Sbjct 195 KRTAMAVHPM-GKPAITHYRIMERFRNYTRLRLRLE--TGRTHQIRVHMAHIAHPLLGDQ 251
Query 180 LY--HPEPAK----------FALKRMALHATSLKFIQPFTQQPLDIVATVP 218
LY P P K A +R ALHAT L+ P + ++ A +P
Sbjct 252 LYGGRPRPPKGSSEAFLTVLRAFQRQALHATMLRLEHPINGELIECHAPLP 302
>P65836 Ribosomal large subunit pseudouridine synthase D [Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=326
Score = 110 bits (275), Expect = 2e-32
Identities = 78/225 (35%), Positives = 115/225 (51%), Gaps = 24/225 (11%)
Query 13 PMCMVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLRIRQQY-------PLARVTHRLDM 65
P+ +VYEDDD++VI+KP L+ G + D L Y P A + HRLD
Sbjct 83 PLDIVYEDDDILVINKPRDLVVHPGA--GNPDGTVLNALLHYYPPIADVPRAGIVHRLDK 140
Query 66 ATSGLLMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWPNRPKQK 125
T+GL++ AK A+ + + Q R I + Y A+ G + A G V P I+ P +
Sbjct 141 DTTGLMVVAKTVPAQTRLVESLQLREITREYEAVAIGHMTAGGTVNEP-ISRHPTKRTHM 199
Query 126 IDFVEGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLY--HP 183
GK A T Y+ +++ + R++LE TGR+HQ+RVHM HI HP++GD++Y P
Sbjct 200 SVHPMGKPAVTHYRIMEHFRVHTRLRLRLE--TGRTHQIRVHMAHITHPLVGDQVYGGRP 257
Query 184 EPAKFA----------LKRMALHATSLKFIQPFTQQPLDIVATVP 218
P K A R ALHAT L+ P + ++ A +P
Sbjct 258 RPPKGASEEFISTLRKFDRQALHATMLRLYHPVSGIEMEWHAPIP 302
>P0AA39 Ribosomal large subunit pseudouridine synthase C [Escherichia
coli (strain K12)]
Length=319
Score = 98.6 bits (244), Expect = 6e-28
Identities = 72/210 (34%), Positives = 115/210 (55%), Gaps = 12/210 (6%)
Query 16 MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLR-IRQQYPLARVTHRLDMATSGLLMFA 74
++YEDD ++V++KP+G G LR +R + + HRLD TSG+L+ A
Sbjct 95 ILYEDDHILVLNKPSGTAVHGGSGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLLVA 154
Query 75 KHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQ-GMVEAPLITDWPNRPKQKIDFV-EGK 132
K R A ++ + + + +QK Y+ALV G+ Q+ V+APL+ + ++ + EGK
Sbjct 155 KKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLLKNILQSGERIVRVSQEGK 214
Query 133 AAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYHPE-------P 185
++T ++ ++ AF T ++ P+TGR+HQ+RVH Q+ GHPI D Y
Sbjct 215 PSETRFK-VEERYAF-ATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDRQLTE 272
Query 186 AKFALKRMALHATSLKFIQPFTQQPLDIVA 215
A L R+ LHA +LKF P T + + I A
Sbjct 273 AGTGLNRLFLHAAALKFTHPGTGEVMRIEA 302
>P0AA41 tRNA pseudouridine synthase C [Escherichia coli (strain
K12)]
Length=260
Score = 92.4 bits (228), Expect = 5e-26
Identities = 68/221 (31%), Positives = 108/221 (49%), Gaps = 24/221 (11%)
Query 16 MVYEDDDLIVIDKPAGLLSVMGRLPEHQDSAYLR-IRQQYPLARVT-HRLDMATSGLLMF 73
++Y+D+ L+ ++KP+G L L + ++ +R Q T HRLD TSG+L+
Sbjct 4 ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
Query 74 AKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMVEAPLITDWPN----------RPK 123
A +++ F+ IQK Y A+V G + + +++ PL+ + P+
Sbjct 64 GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
Query 124 QKIDFVEGKAAKTCYQPLDYNAAFNQTR---IQLEPITGRSHQLRVHMQHIGHPIMGDKL 180
+ G A T P+ + TR ++LEP TGR HQLR H+ H+ HPI+GD
Sbjct 124 PAVTHYRGLA--TVEMPVA-TGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
Query 181 Y------HPEPAKFALKRMALHATSLKFIQPFTQQPLDIVA 215
+ F L+R+ LHA+ L PFT +PL I A
Sbjct 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
>Q8IZ73 Pseudouridylate synthase RPUSD2 [Homo sapiens]
Length=545
Score = 94.4 bits (233), Expect = 1e-25
Identities = 56/173 (32%), Positives = 95/173 (55%), Gaps = 5/173 (3%)
Query 12 DPMCMVYEDDDLIVIDKPAGL-LSVMGRLPEHQDSAYLRIRQQYPLARVTHRLDMATSGL 70
+P+ ++ E++D++V+DKP+ + + GR + L Q HRLD TSG+
Sbjct 221 EPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGV 280
Query 71 LMFAKHRRAEIAISKLFQTRCIQKYYIALVDGEVQAQGMV-EAPLITDWPNRPKQKIDFV 129
LMFAK I + + R ++K Y+ V+GE + + + P++ ++D
Sbjct 281 LMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEEVTCKEPILVVSYKVGVCRVD-P 339
Query 130 EGKAAKTCYQPLDYNAAFNQTRIQLEPITGRSHQLRVHMQHIGHPIMGDKLYH 182
GK +T +Q L YN + R + P+TGR+HQ+RVH+Q +GHPI+ D +Y+
Sbjct 340 RGKPCETVFQRLSYNGQSSVVRCR--PLTGRTHQIRVHLQFLGHPILNDPIYN 390
Lambda K H a alpha
0.327 0.140 0.428 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 819808
Database: b7022d79209420ab5c0323ef637face3.SwissProt.fasta
Posted date: Jun 1, 2024 9:49 AM
Number of letters in database: 5,538
Number of sequences in database: 20
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
