BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 018e802c6975f0d63103267619b2cf63.SwissProt.fasta
11 sequences; 6,358 total letters
Query= ACIAD0929
Length=654
Score E
Sequences producing significant alignments: (Bits) Value
P54422 Glutathione hydrolase proenzyme [Bacillus subtilis (strain... 297 1e-95
P63186 Glutathione hydrolase proenzyme [Bacillus subtilis subsp. ... 280 3e-89
P18956 Glutathione hydrolase proenzyme [Escherichia coli (strain ... 256 3e-80
P36267 Glutathione hydrolase proenzyme [Pseudomonas sp. (strain A... 224 2e-68
Q9I406 Glutathione hydrolase proenzyme [Pseudomonas aeruginosa (s... 214 1e-64
Q680I5 Glutathione hydrolase 2 [Arabidopsis thaliana] 196 5e-58
Q05053 Cephalosporin acylase / Gamma-glutamyltranspeptidase [Pseu... 190 4e-56
Q8VYW6 Glutathione hydrolase 1 [Arabidopsis thaliana] 190 7e-56
P15557 Cephalosporin acylase / Gamma-glutamyltranspeptidase [Pseu... 189 8e-56
Q9M0G0 Glutathione hydrolase 3 [Arabidopsis thaliana] 191 1e-55
P19440 Glutathione hydrolase 1 proenzyme [Homo sapiens] 171 4e-49
>P54422 Glutathione hydrolase proenzyme [Bacillus subtilis (strain
168)]
Length=587
Score = 297 bits (761), Expect = 1e-95
Identities = 210/618 (34%), Positives = 303/618 (49%), Gaps = 57/618 (9%)
Query 44 LTSDGSTVVVGSGQVGDPSAPEPASAYRLGLKAKTSNQYMVVANTPLATKAGCDILKAGG 103
LT+ S ++V A +P +Y + MV PLA++ G D+LK GG
Sbjct 9 LTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVGKDGMVATAHPLASEIGADVLKKGG 68
Query 104 SAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVTAYDGRETAPAAANEYYLVRQ 163
+A+DAA+A+Q L + EP S I G FMM YD +T+ T D RE APA A + +
Sbjct 69 NAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKTKDTTIIDSRERAPAGATPDMFLDE 128
Query 164 NLEDPNSLAPVPSARRSGRSIGVPGVMRMLEMAHNEHGKLRWNQLFDNSVQLAEGGFKVP 223
N P G ++GVPG ++ LE A ++ G QL S++LAE GF +
Sbjct 129 N----GKAIPFSERVTKGTAVGVPGTLKGLEEALDKWGTRSMKQLITPSIKLAEKGFPID 184
Query 224 GRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGETMTNQDYARTIRTIAANGAQAMYS 283
LA AI L+ A K F +G P + G+T+ +D A+T + I + G A Y
Sbjct 185 SVLAEAISDYQEKLS--RTAAKDVFLPNGEPLKEGDTLIQKDLAKTFKLIRSKGTDAFYK 242
Query 284 GTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAKKRDAICFTYRSQYHVCTMPP 343
G A+ + Q G MT DL NY + I Y+ Y + T PP
Sbjct 243 GKFAKTLSDTVQDFGGS-----------MTEKDLENYDITIDEPIWGDYQG-YQIATTPP 290
Query 344 PSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTVMGVHLVSEAERLAYADRDKYVAD 403
PSSGGI + Q L IL++F+L+ Y E L++E L+YADR Y D
Sbjct 291 PSSGGIFLLQMLKILDHFNLSQYDVRSWEK---------YQLLAETMHLSYADRASYAGD 341
Query 404 TDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVATAGD-FSVNAGIDN---------T 453
+FV +P +G +L+ +Y+K+R LIN DQ K AGD + G N
Sbjct 342 PEFVNVPLKG---LLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQVEQPKDK 398
Query 454 VEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMVD--GFLLTNQLTDFSAQPVDSTGNLV 511
VE TT FT+AD +GNVVS T+T+E G+ MV G +L N+LTDF A P
Sbjct 399 VEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIPGG------ 452
Query 512 ANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKTLVGALDWNLDAQQ 571
AN VQ NKRP S+M PT++FK P + GSPGG TII V++T++ +++ ++ +
Sbjct 453 ANEVQPNKRPLSSMTPTILFKDDKP---VLTVGSPGGATIISSVLQTILYHIEYGMELKA 509
Query 572 ATSLVNFGATNSANTNVDSSNTSLDLTALIDGLKAKGHGINSSAQSSGVATIMRIAIQNQ 631
A TNS ++ D+ + ++G+ GH +S G + I+I ++
Sbjct 510 AVEEPRI-YTNSMSSYRYEDGVPKDVLSKLNGM---GHKFGTSPVDIG--NVQSISIDHE 563
Query 632 QIKYVGGVDPRREGIVLG 649
+ G D R G +G
Sbjct 564 NGTFKGVADSSRNGAAIG 581
>P63186 Glutathione hydrolase proenzyme [Bacillus subtilis subsp.
natto]
Length=587
Score = 280 bits (717), Expect = 3e-89
Identities = 202/605 (33%), Positives = 293/605 (48%), Gaps = 55/605 (9%)
Query 44 LTSDGSTVVVGSGQVGDPSAPEPASAYRLGLKAKTSNQYMVVANTPLATKAGCDILKAGG 103
LT+ S ++V A +P +Y + MV LA++ G D+LK GG
Sbjct 9 LTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVGKDGMVATAHALASEIGADVLKKGG 68
Query 104 SAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVTAYDGRETAPAAANEYYLVRQ 163
+A+DAA+A+Q L + EP S I G FMM YD +T+ T D RE APA A + +
Sbjct 69 NAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKTKDTTIIDSRERAPAGATPDMFLDE 128
Query 164 NLEDPNSLAPVPSARRSGRSIGVPGVMRMLEMAHNEHGKLRWNQLFDNSVQLAEGGFKVP 223
N P G ++GVPG ++ LE A ++ G L +++LAE GF +
Sbjct 129 N----GKAIPFSERVTKGTAVGVPGTLKGLEEALDKWGTRSMKLLITLTIKLAEKGFPID 184
Query 224 GRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGETMTNQDYARTIRTIAANGAQAMYS 283
LA AI L+ A K F +G P + G+T+ +D A+T + I + G A Y
Sbjct 185 SVLADAISDYQEKLS--RTAAKDVFLPNGEPLKEGDTLIQKDLAKTFKLIRSKGTDAFYK 242
Query 284 GTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAKKRDAICFTYRSQYHVCTMPP 343
G A+ + Q G MT DL NY + I Y+ Y + T PP
Sbjct 243 GKFAKTLSDTVQDFGGS-----------MTEKDLENYDITIDEPIWGDYQG-YQIATTPP 290
Query 344 PSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTVMGVHLVSEAERLAYADRDKYVAD 403
PSSGGI + Q L IL++F+L+ Y E L++E L+YADR Y D
Sbjct 291 PSSGGIFLLQMLKILDDFNLSQYDVRSWEK---------YQLLAETMHLSYADRASYAGD 341
Query 404 TDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVATAGD-FSVNAGIDN---------T 453
+FV +P +G +L+ +Y+K+R LIN DQ K AGD + G N
Sbjct 342 PEFVNVPLKG---LLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQVEQPKDK 398
Query 454 VEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMVD--GFLLTNQLTDFSAQPVDSTGNLV 511
VE TT FT+AD +GNVVS T+T+E G+ MV G +L N+LTDF A P
Sbjct 399 VEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIPGG------ 452
Query 512 ANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKTLVGALDWNLDAQQ 571
AN VQ NKRP S+M PT++FK P + GSPGG TII V++T++ +++ + +
Sbjct 453 ANEVQPNKRPLSSMTPTILFKDDKP---VLTVGSPGGATIISSVLQTILYHIEYGMGLKA 509
Query 572 ATSLVNFGATNSANTNVDSSNTSLDLTALIDGLKAKGHGINSSAQSSGVATIMRIAIQNQ 631
A T+ ++ + D+ + ++G+ GH +S G + I +N
Sbjct 510 AVEEPRIYTTSMSSYRYE-DGVPKDVLSKLNGM---GHRFGTSPVDIGNVQSISIDHENG 565
Query 632 QIKYV 636
K V
Sbjct 566 TFKGV 570
>P18956 Glutathione hydrolase proenzyme [Escherichia coli (strain
K12)]
Length=580
Score = 256 bits (654), Expect = 3e-80
Identities = 184/541 (34%), Positives = 279/541 (52%), Gaps = 60/541 (11%)
Query 55 SGQVGDPSAPEPASAYRLGLKAKT-----SNQYMVVANTPLATKAGCDILKAGGSAVDAA 109
SG +A PA G++ + Q MV + AT+ G DILK GG+AVDAA
Sbjct 17 SGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAA 76
Query 110 IAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVTAYDGRETAPA-AANEYYLVRQNLEDP 168
+AV L + PQ+ + G FM+ ++ TA D RE APA A + +L Q +P
Sbjct 77 VAVGYALAVTHPQAGNLGGGGFMLIR-SKNGNTTAIDFREMAPAKATRDMFLDDQG--NP 133
Query 169 NSLAPVPSARRSGRSIGVPGVMRMLEMAHNEHGKLRWNQLFDNSVQLAEGGFKVPGRLAA 228
+S + S SG PG + +A +++G + N++ + +LA GF V LA
Sbjct 134 DSKKSLTSHLASG----TPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVNDALAD 189
Query 229 AIQSNAASLALDANAVKTYFHADGSPYQVGETMTNQDYARTIRTIAANGAQAMYSGTIAQ 288
+++ + + + K F +G P + G+T+ + A+++ IA NG Y GTIA+
Sbjct 190 DLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPDEFYKGTIAE 249
Query 289 AIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAKKRDAICFTYRSQYHVCTMPPPSSGG 348
I + Q++ G L+T DLA Y+A +R I YR Y V +MPPPSSGG
Sbjct 250 QIAQEMQKNGG-----------LITKEDLAAYKAVERTPISGDYRG-YQVYSMPPPSSGG 297
Query 349 IAVAQTLGILENFDLASYGPTQPETEGGVPTVMGVHLVSEAERLAYADRDKYVADTDFVP 408
I + Q L ILENFD+ Y G + + +++EAE+ AYADR +Y+ D DFV
Sbjct 298 IHIVQILNILENFDMKKY---------GFGSADAMQIMAEAEKYAYADRSEYLGDPDFVK 348
Query 409 LPAQGVSSMLNKNYLKQRAGLIN-----PDQSMKVATAGDFSVNAGIDNTVEHGTTQFTI 463
+P Q ++ NK Y K A I+ P ++ + N TT +++
Sbjct 349 VPWQ---ALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQ---------TTHYSV 396
Query 464 ADAYGNVVSMTSTVESSMGSFHMV--DGFLLTNQLTDFSAQP-VDSTGNLV---ANRVQA 517
D GN V++T T+ ++ G+ + G LL NQ+ DFSA+P V + LV AN V
Sbjct 397 VDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGP 456
Query 518 NKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKTLVGALDWNLDAQQATSLVN 577
NKRP S+M+PT+V K G ++ TGSPGG II V++ +V ++D+ L+ +AT+
Sbjct 457 NKRPLSSMSPTIVVK---DGKTWLVTGSPGGSRIITTVLQMVVNSIDYGLNVAEATNAPR 513
Query 578 F 578
F
Sbjct 514 F 514
>P36267 Glutathione hydrolase proenzyme [Pseudomonas sp. (strain
A14)]
Length=575
Score = 224 bits (572), Expect = 2e-68
Identities = 175/580 (30%), Positives = 278/580 (48%), Gaps = 54/580 (9%)
Query 83 MVVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKV 142
MVV +A+K G ++LK+GG+A+DAA+AV L +V P + I G FM A +K
Sbjct 36 MVVTAQHIASKVGVEVLKSGGNAIDAAVAVGYALAVVYPAAGNIGGGGFMTIQLADGRK- 94
Query 143 TAYDGRETAPAAAN-EYYLVRQNLEDPNSLAPVPSARRSG-RSIGVPGVMRMLEMAHNEH 200
T D RE AP AA YL + D N + A +G ++GVPG + +E A ++
Sbjct 95 TFLDFREKAPLAATANMYLDK----DGN---VIKGASTTGYLAVGVPGTVSGMEYAREKY 147
Query 201 GKLRWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGET 260
G QL ++ LA+ GF + + ++ D F G P+Q GE
Sbjct 148 GTKTRQQLISPAITLADKGFVLEQGDVDMLWTSTKDFEKDRANSGAIFMNKGQPFQPGER 207
Query 261 MTNQDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANY 320
+ +D ART+R I+A G Y G +A ++A + G ++T DL Y
Sbjct 208 LVQKDLARTLRLISAKGTDGFYKGEVADKLVASMKAGGG-----------IITQADLDQY 256
Query 321 QAKKRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTV 380
+ ++ + YR YHV + PPPSSGG+ + + + ILE + P E G +
Sbjct 257 KTRELAPVECDYRG-YHVVSAPPPSSGGVVICEIMNILEGY---------PMKELGYHSA 306
Query 381 MGVHLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVAT 440
GVH EA R AY DR+ Y+ D DFV P ++ +L+K+Y + INP ++
Sbjct 307 QGVHYTIEAMRHAYVDRNSYLGDPDFVKNP---LAHLLDKDYAAKIRAAINPQKA----- 358
Query 441 AGDFSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMVD--GFLLTNQLTD 498
+ G+ TT ++I D GN VS+T T+ G+ M + G LL +++ D
Sbjct 359 GISQEIKPGVPPHEGSNTTHYSIVDKDGNAVSVTYTLNDWFGAKVMANGTGVLLNDEMDD 418
Query 499 FSAQ-PVDSTGNLV---ANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQY 554
F+++ V + L+ AN + +RP S+M+PT+V T G M G+PGG II
Sbjct 419 FTSKVGVPNMYGLIQGEANAIGPGRRPLSSMSPTIV---TKDGKTVMVVGTPGGSRIITA 475
Query 555 VVKTLVGALDWNLDAQQATSLVNFGAT-NSANTNVDSSNTSLDLTALIDGLKAKGHGINS 613
+ T++ +D+ ++ Q+A F +TN+++ S D +++ K G
Sbjct 476 TLLTMLNMIDYGMNLQEAVDAPRFHQQWMPESTNIEAFALSPDTQKILESWGQKFAG-PQ 534
Query 614 SAQSSGVATIMRIAIQNQQI---KYVGGVDPRRE-GIVLG 649
A + ++ + I ++ G DPRR G+ LG
Sbjct 535 PANHIAAILVGAPSLGGKPIGKNRFYGANDPRRNTGLALG 574
>Q9I406 Glutathione hydrolase proenzyme [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 /
LMG 12228 / 1C / PRS 101 / PAO1)]
Length=557
Score = 214 bits (544), Expect = 1e-64
Identities = 185/584 (32%), Positives = 274/584 (47%), Gaps = 65/584 (11%)
Query 76 AKTSNQYMVVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYY 135
A T + V A K ILKAGG+AVDAA+A L + P++ I G FM Y
Sbjct 24 AATLDGGAVAAPDEYGAKVAAQILKAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFMTLY 83
Query 136 DAQTQKVTAYDGRETAPAAANEYYLVRQNLEDPNSLAPVPSARRSGRSIGVPGVMRMLEM 195
K D RE AP AA++ + E +L+ V ++ GVPG + L
Sbjct 84 --MDGKPYFLDYREVAPKAASKTMYLDDKGEVIENLSLV-----GAKAAGVPGTVMGLWE 136
Query 196 AHNEHGKLRWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPY 255
AH GKL W++L ++ A+ GFKV + Q ++AL KT F
Sbjct 137 AHKRFGKLPWSELLTPAIGYAQKGFKVADK---QFQYRQDAVALFNG--KTNFGDYFGHM 191
Query 256 QVGETMTNQDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLN 315
+ GE D A+T+ IA G Y G A ++A+ QQDKG L+T
Sbjct 192 KAGEAFLQPDLAKTLERIADKGPDEFYKGHTADLLVAQMQQDKG-----------LITHQ 240
Query 316 DLANYQAKKRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEG 375
DLA+Y+ + R+ + ++ + T P PSSGGIA+AQ LGI EN G
Sbjct 241 DLADYKVRWREPMRVDWQGN-TLYTAPLPSSGGIALAQLLGIKENRAADFKGVE------ 293
Query 376 GVPTVMGVHLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQS 435
+ + +HL++E E+ +ADR Y+ D DF +P V+ + + YLKQRA +NP
Sbjct 294 -LNSARYIHLLAEIEKRVFADRADYLGDPDFSKVP---VARLTDPAYLKQRAAEVNP--- 346
Query 436 MKVATAGDFSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMVD--GFLLT 493
A + V G++ H TT F+I DA GN VS T T+ GS +V GFLL
Sbjct 347 --TAISPTEKVRPGLE---PHQTTHFSIVDADGNAVSNTYTLNWDFGSGVVVKGAGFLLN 401
Query 494 NQLTDFSAQP-VDSTGNLV---ANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGG 549
+++ DFSA+P V + +V AN ++ KR S+M+P++V T G + G+PGG
Sbjct 402 DEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPSIV---TRDGKVSLVVGTPGGS 458
Query 550 TIIQYVVKTLVGALDWNLDAQQATSLVNFGATNSANTNVDSSNTSLDLTALIDG-----L 604
I + + L D++L ++A + A + + D A + G L
Sbjct 459 RIFTSIFQVLNNIYDFHLPLEKAVA-----AQRVHHQLLPKDTIYYDAYAPLAGKVAEEL 513
Query 605 KAKGHGINSSAQSSGVATIMRIAIQNQQIKYVGGVDPRREGIVL 648
KA G+ + + G I I + + ++ DPR G+ L
Sbjct 514 KAMGYTLEDQGWNMG--DIQAIRVDGKALETAS--DPRGRGVGL 553
>Q680I5 Glutathione hydrolase 2 [Arabidopsis thaliana]
Length=578
Score = 196 bits (498), Expect = 5e-58
Identities = 154/483 (32%), Positives = 230/483 (48%), Gaps = 54/483 (11%)
Query 95 GCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVTAYDGRETAPAA 154
G ++L+ GG+A+DA++A LG+V P SS I G AF M A +V AYD RETAP +
Sbjct 51 GTNVLRQGGNAIDASVAAALCLGVVSPASSGIGGGAFTMIKLANGTEV-AYDSRETAPLS 109
Query 155 ANEYYLVRQNLEDPNSLAPVPSARRSGR-SIGVPGVMRMLEMAHNEHGKLRWNQLFDNSV 213
A E + P ++ G S+GVPG + L A +HGKL W QL + +
Sbjct 110 ATE-----------DMYGDNPERKKKGSLSVGVPGEVAGLYTAWTQHGKLPWKQLVEPAE 158
Query 214 QLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGETMTNQDYARTIRTI 273
+LA GFK+ L + + + + D + F ++G + G N A T+ I
Sbjct 159 KLAAEGFKISKYLYMQMNATRSDILAD-KGLSELFVSNGELKKPGAICRNPKLADTLSQI 217
Query 274 AANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAKKRDAICFTYR 333
A G +A Y+GT+ +++ Q+ G ++TL DL NY K ++ + T
Sbjct 218 AEYGPKAFYNGTVGFNLVSDIQKAGG-----------IITLKDLQNYNVKVKEPLS-TEI 265
Query 334 SQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTVMGVHLVSEAERLA 393
Y + MPPPSSGG A+ L IL + + S GV +GVH + EA + A
Sbjct 266 LGYRLLGMPPPSSGGPAMMLILNILAQYGIPS----------GVSGPLGVHRLVEALKHA 315
Query 394 YADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVATAGDFSVNAGIDNT 453
+A R + D DFVP V+ ML+ + + IN +++ G
Sbjct 316 FAVR-MNLGDPDFVPEVTNVVADMLSPKFAQDLKSKINDEKTFDPKYYG-----GKWGQI 369
Query 454 VEHGTTQFTIADAYGNVVSMTSTVESSMGSFHM--VDGFLLTNQLTDFSAQPVDSTGN-- 509
+HGT+ +I D+ N VSMTST+ G+ + G +L N++ DFS P S G+
Sbjct 370 KDHGTSHLSIIDSERNAVSMTSTINGYFGAIMLSPSTGIVLNNEMDDFSI-PTKSGGDPD 428
Query 510 ----LVANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKTLVGALDW 565
AN ++ KRP S+M PT+V K G A G+ GG II + +
Sbjct 429 VPPPAPANFIRPGKRPLSSMTPTIVLK---DGKVKAALGASGGMYIIAGTTQVYLNHFFL 485
Query 566 NLD 568
N+D
Sbjct 486 NMD 488
Score = 20.8 bits (42), Expect = 1.9
Identities = 14/54 (26%), Positives = 24/54 (44%), Gaps = 6/54 (11%)
Query 22 NDSNDQEQTSTI------VDTNPNSCNQLTSDGSTVVVGSGQVGDPSAPEPASA 69
++ N TSTI + +P++ L ++ + + GDP P PA A
Sbjct 382 SERNAVSMTSTINGYFGAIMLSPSTGIVLNNEMDDFSIPTKSGGDPDVPPPAPA 435
>Q05053 Cephalosporin acylase / Gamma-glutamyltranspeptidase [Pseudomonas
sp. (strain V22)]
Length=558
Score = 190 bits (483), Expect = 4e-56
Identities = 157/505 (31%), Positives = 234/505 (46%), Gaps = 54/505 (11%)
Query 75 KAKTSNQYMVVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMY 134
K T ++ MVV N PLA+ AG IL AGG+A+DAA+A L + EP I G
Sbjct 18 KPATGSRGMVVTNHPLASAAGAQILLAGGNAIDAAVASLFALTVAEPMMVGILGGGLSHI 77
Query 135 YDAQTQKVTAYDGRETAP--AAANEYYLVRQNL---EDPNSLAPVPSARRSGRSIGVPGV 189
A + V D TAP A A+ Y + + D V A +++ VPG
Sbjct 78 RLADGRHV-VIDNLSTAPGKATADMYECLSDEIGKQRDTRDRENVVGA----KAVAVPGA 132
Query 190 MRMLEMAHNEHGKLRWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFH 249
++ A G L ++ ++ LAE GF V L+ I NAA LA D +
Sbjct 133 LKGWCEALARFGTLPLAEVLQPAIGLAERGFVVTPYLSNCITDNAADLARDP-GLAAMLL 191
Query 250 ADGSPYQVGETMTNQDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITP 309
G P Q G + DYA +++ IAA G +A+Y G + +A+ + G
Sbjct 192 PGGQPLQPGMRLIQSDYAASLKLIAAEGPEALYGGKLGRALTDYMAANGG---------- 241
Query 310 SLMTLNDLANYQAKKRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPT 369
L+ DL+NY+ + R+ I +YR Y + PPPSS G+ +AQ L ILE +D+ +
Sbjct 242 -LIDQADLSNYRIELREPIRGSYRG-YEIIGPPPPSSSGVHIAQMLNILEGYDIGAL--- 296
Query 370 QPETEGGVPTVMGVHLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGL 429
G + VHL++EA ++A+ADR AD FV +P V+ +++K Y +R L
Sbjct 297 ------GFGSTDAVHLLAEALKIAFADRAVATADPAFVKVP---VARLIDKAYADERRAL 347
Query 430 INPDQSMKVATAGDFSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMV-- 487
I +Q+ S AG+ TT T+ADA GNVVS T T+ G+
Sbjct 348 IAMEQAK--------SWTAGLSGGESADTTHVTVADAMGNVVSATQTINGLFGACVQTPG 399
Query 488 DGFLLTNQLTDFSAQPVDSTGNLVANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPG 547
G + N + +F P G ++ + KR ++MAP + K G A G PG
Sbjct 400 TGMIANNYMYNFDPHP----GRALS--IAPGKRVFTSMAPMMAVK---EGRLAFALGLPG 450
Query 548 GGTIIQYVVKTLVGALDWNLDAQQA 572
I ++ +V +D + Q+A
Sbjct 451 ALRIFPSALQAIVNLIDHRMSLQEA 475
>Q8VYW6 Glutathione hydrolase 1 [Arabidopsis thaliana]
Length=572
Score = 190 bits (482), Expect = 7e-56
Identities = 170/573 (30%), Positives = 267/573 (47%), Gaps = 66/573 (12%)
Query 95 GCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVTAYDGRETAPAA 154
G +L+ GG+A+DA++A LG+V P SS I G AF + A +++ AYD RETAP
Sbjct 47 GMRVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTVVKIAGGKEI-AYDSRETAPLR 105
Query 155 ANEYYLVRQNLEDPNSLAPVPSARRSGRSIGVPGVMRMLEMAHNEHGKLRWNQLFDNSVQ 214
A E N+ N V ++ S+GVPG + L A +HGKL W +L + +
Sbjct 106 ATE------NMYGGN----VDLKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVTPAEK 155
Query 215 LAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGETMTNQDYARTIRTIA 274
LAE GFK+ L + + + + D + F ++G + G N A T++ I
Sbjct 156 LAE-GFKISKYLYMQMNATRSDILAD-KGLSDLFVSNGELKKPGTICHNPKLALTLKLIG 213
Query 275 ANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAKKRDAICFTYRS 334
G +A Y+GT+ + ++ G ++TL DL +Y+ K ++ +
Sbjct 214 EYGPKAFYNGTVGVNLARDIKKSGG-----------IITLKDLQSYRVKIKEPLSADILG 262
Query 335 QYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTVMGVHLVSEAERLAY 394
Y V MPPPSSGG A+ L IL + + S GV +GVH + EA + A+
Sbjct 263 -YRVLGMPPPSSGGAAMMLVLNILSQYGIPS----------GVSGPLGVHRLIEALKHAF 311
Query 395 ADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVATAGDFSVNAGIDNTV 454
A R + D DF + + VS ML+ + K IN ++ D G+ N +
Sbjct 312 AVR-MNLGDPDFTDV-TKVVSDMLSPKFAKDLKSKINDQKTF------DPKYYGGMWNQI 363
Query 455 -EHGTTQFTIADAYGNVVSMTSTVESSMGSFHM--VDGFLLTNQLTDFSAQPVDSTGNL- 510
+HGT+ +I D N VSMTST+ G+ + G +L N++ DFS P+ S GNL
Sbjct 364 DDHGTSHLSIIDRERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSI-PMKSNGNLD 422
Query 511 -----VANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKTLVGALDW 565
AN ++ KRP S+M+PT+V K G A G+ GG II + +
Sbjct 423 VPPPAPANFIRPGKRPLSSMSPTIVLK---DGKVKAAVGASGGANIIAGTTEVYLNHFFL 479
Query 566 NLDAQQAT-------SLVNFGATNSANTNVDSSNTSLDLTALIDGLKAKGHGINSSAQSS 618
+D + L+ A+ T V + + + + L+ KGH ++ A +
Sbjct 480 KMDPLSSVLAPRIYHQLIPNRASYENWTTVFNDHFEIPKATRV-VLEKKGHVLSPIAGGT 538
Query 619 GVATIMRIAIQNQ--QIKYVGGVDPRREGIVLG 649
I++ + +N + + V DPR+ G G
Sbjct 539 IAQFIVQESGENSGGRSELVAVSDPRKGGFPSG 571
>P15557 Cephalosporin acylase / Gamma-glutamyltranspeptidase [Pseudomonas
sp. (strain SE83)]
Length=558
Score = 189 bits (481), Expect = 8e-56
Identities = 156/505 (31%), Positives = 231/505 (46%), Gaps = 54/505 (11%)
Query 75 KAKTSNQYMVVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMY 134
K + ++ MVV N PLA+ AG IL AGG+A+DAA+A L + EP I G
Sbjct 18 KPASGSRGMVVTNHPLASAAGAQILLAGGNAIDAAVASLFALTVAEPMMVGILGGGLSHI 77
Query 135 YDAQTQKVTAYDGRETAP--AAANEYYLVRQNL---EDPNSLAPVPSARRSGRSIGVPGV 189
A + V D TAP A A Y + + D V A +++ VPG
Sbjct 78 RLADGRHV-VIDNLSTAPGKATAEMYECLSDEIGKQRDTRDRQNVVGA----KAVAVPGA 132
Query 190 MRMLEMAHNEHGKLRWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFH 249
++ A G L ++ ++ LAE GF V L+ I NA LA D +
Sbjct 133 LKGWCEALARFGTLPLAEVLQPAIGLAERGFVVTPYLSNCITDNAGDLARDP-GLAAMLL 191
Query 250 ADGSPYQVGETMTNQDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITP 309
G P Q G + DYA +++ IAA G A+Y G + +A+ + G
Sbjct 192 PGGKPLQPGMRLVQSDYAASLKLIAAEGPDALYGGKLGRALTDYMAANGG---------- 241
Query 310 SLMTLNDLANYQAKKRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPT 369
L+ DLANY+ + R+ I +YR Y + PPPSS G+ + Q L ILE +D+ S
Sbjct 242 -LIDQADLANYRIELREPIRGSYRG-YEIIGPPPPSSSGVHITQMLNILEGYDIGSL--- 296
Query 370 QPETEGGVPTVMGVHLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGL 429
G + VHL++EA ++A+ADR AD FV +P V+ +++K Y +R L
Sbjct 297 ------GFGSTDAVHLLAEALKIAFADRAVATADPAFVKVP---VARLIDKAYADERRAL 347
Query 430 INPDQSMKVATAGDFSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGSFHMV-- 487
I +Q+ S AG+ TT T+ADA GNVVS T T+ G+ +
Sbjct 348 IEMEQAK--------SWTAGLSGGESADTTHVTVADAMGNVVSATQTINGLFGACVQIPG 399
Query 488 DGFLLTNQLTDFSAQPVDSTGNLVANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPG 547
G + N + +F P G ++ + KR ++MAP + K G A G PG
Sbjct 400 TGMIANNYMYNFDPHP----GRALS--IAPGKRVFTSMAPMMALK---EGRIAFALGLPG 450
Query 548 GGTIIQYVVKTLVGALDWNLDAQQA 572
I ++ +V +D + Q+A
Sbjct 451 ALRIFPSALQAIVNLIDHRMSLQEA 475
>Q9M0G0 Glutathione hydrolase 3 [Arabidopsis thaliana]
Length=637
Score = 191 bits (484), Expect = 1e-55
Identities = 146/500 (29%), Positives = 246/500 (49%), Gaps = 49/500 (10%)
Query 79 SNQYMVVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQ 138
S +V A+ ++ G +L++GG AVDAA+A+ +G+V P SS I G +F++ +
Sbjct 78 SENGVVAADDARCSEIGASVLRSGGHAVDAAVAITLCVGVVNPMSSGIGGGSFLIVSSQK 137
Query 139 TQKVTAYDGRETAPAAANEYYLVRQNLEDPNSLAPVPSARRSGRSIGVPGVMRMLEMAHN 198
K A+D RETAP AA++ + +N SL + S+GVPG + L A
Sbjct 138 DSKAEAFDMRETAPLAASKD--MYKNDASAKSLGAL--------SMGVPGEIAGLYEAWK 187
Query 199 EHGKLRWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPYQVG 258
+G+L W LF+ +++LA GF V L AI + A + D +++ F +G + G
Sbjct 188 RYGRLPWKPLFEPAIKLARDGFVVYPYLGKAISTKVAMILKDP-GMRSVFSRNGQVLKTG 246
Query 259 ETMTNQDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLA 318
ET N + A+++ TI+ G A Y+GT+ + ++ ++ G ++T++DL
Sbjct 247 ETCYNPELAQSLETISEQGPGAFYNGTVGEKLVKDVKKAGG-----------IITMDDLR 295
Query 319 NYQAKKRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEGGVP 378
+Y+ + DA+ Y V MPPPS G + + + IL+++ + T G
Sbjct 296 SYKVRVTDAMSVDVMG-YTVHGMPPPSGGTVGFSMVMNILDSY-------SNLYTASG-- 345
Query 379 TVMGVHLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKV 438
+G+H + EA + +A R + D +FV V++ +N+ K A I
Sbjct 346 RELGLHRLIEAMKHMFAAR-MDLGDPEFV-----NVTNSMNQMLSKAHAEEIQKRIFDNT 399
Query 439 ATAGDFSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGS--FHMVDGFLLTNQL 496
++ +N + GT+ F + DA N VSMTSTV G+ G +L N++
Sbjct 400 TFPPEYYMNRW-SQLRDQGTSHFCVVDADRNSVSMTSTVNYRFGAGVLSPSTGIVLNNEM 458
Query 497 TDFSAQPVDSTGNLV----ANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTII 552
DFS P + T +++ N ++ NKRP S+M P ++ T G+F A G GG II
Sbjct 459 DDFST-PTEITPDMLPPAPTNFIEPNKRPLSSMTPLVI---TKDGEFVAALGGAGGMHII 514
Query 553 QYVVKTLVGALDWNLDAQQA 572
V++ + N+ ++A
Sbjct 515 PAVLQVFLNCFVLNMKPKEA 534
>P19440 Glutathione hydrolase 1 proenzyme [Homo sapiens]
Length=569
Score = 171 bits (433), Expect = 4e-49
Identities = 154/548 (28%), Positives = 244/548 (45%), Gaps = 48/548 (9%)
Query 84 VVANTPLATKAGCDILKAGGSAVDAAIAVQAVLGLVEPQSSTIAGSAFMMYYDAQTQKVT 143
V A+ +K G D L+ GGSAVDAAIA +GL+ S I G F+ Y++ T+K
Sbjct 43 VAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAE 102
Query 144 AYDGRETAPAAANEYYLVRQNLEDPNSLAPVPSARRSGRSIGVPGVMRMLEMAHNEHGKL 203
+ RE AP A + N + +++ G S+ VPG +R E+AH HG+L
Sbjct 103 VINAREVAPRLA---FATMFNSSE--------QSQKGGLSVAVPGEIRGYELAHQRHGRL 151
Query 204 RWNQLFDNSVQLAEGGFKVPGRLAAAIQSNAASLALDANAVKTYFHADGSPYQVGETMTN 263
W +LF S+QLA GF V LAAA++ N ++ + F D + GE +T
Sbjct 152 PWARLFQPSIQLARQGFPVGKGLAAALE-NKRTVIEQQPVLCEVFCRDRKVLREGERLTL 210
Query 264 QDYARTIRTIAANGAQAMYSGTIAQAIIAKAQQDKGDDAANTPITPSLMTLNDLANYQAK 323
A T T+A GAQA Y+G++ I+ Q G ++T DL NY+A+
Sbjct 211 PQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGG-----------IVTAEDLNNYRAE 259
Query 324 KRDAICFTYRSQYHVCTMPPPSSGGIAVAQTLGILENFDLASYGPTQPETEGGVPTVMGV 383
+ V MP G +A L IL+ ++ + PE +G +
Sbjct 260 LIEHPLNISLGDV-VLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKG-----LTY 313
Query 384 HLVSEAERLAYADRDKYVADTDFVPLPAQGVSSMLNKNYLKQRAGLINPDQSMKVATAGD 443
H + EA R AYA R + D FV + + V +M ++ + Q I+ D + ++
Sbjct 314 HRIVEAFRFAYAKR-TLLGDPKFVDV-TEVVRNMTSEFFAAQLRAQISDDTTHPIS---- 367
Query 444 FSVNAGIDNTVEHGTTQFTIADAYGNVVSMTSTVESSMGS--FHMVDGFLLTNQLTDFSA 501
+ GT ++ G+ VS TST+ GS V G L N++ DFS+
Sbjct 368 -YYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSS 426
Query 502 QPVDSTGNL---VANRVQANKRPRSTMAPTLVFKGTAPGDFYMATGSPGGGTIIQYVVKT 558
+ + + AN +Q K+P S+M PT++ G M G+ GG I
Sbjct 427 PSITNEFGVPPSPANFIQPGKQPLSSMCPTIMV--GQDGQVRMVVGAAGGTQITTATALA 484
Query 559 LVGALDWNLDAQQATSLVNFGATNSANTNVDSSNTSLDLTALIDGLKAKGHGINSSAQSS 618
++ L + D ++A N NV + ++D A+ L+ + H ++ S+
Sbjct 485 IIYNLWFGYDVKRAVEEPRL--HNQLLPNVTTVERNID-QAVTAALETRHH--HTQIAST 539
Query 619 GVATIMRI 626
+A + I
Sbjct 540 FIAVVQAI 547
Lambda K H a alpha
0.314 0.129 0.367 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3458400
Database: 018e802c6975f0d63103267619b2cf63.SwissProt.fasta
Posted date: May 29, 2024 4:16 PM
Number of letters in database: 6,358
Number of sequences in database: 11
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
