BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 22dd2775dd2b5c0e3a30ea390dd492e2.SwissProt.fasta
22 sequences; 6,943 total letters
Query= ACIAD0964
Length=294
Score E
Sequences producing significant alignments: (Bits) Value
Q8U458 Ribose-phosphate pyrophosphokinase [Pyrococcus furiosus (s... 81.6 3e-21
Q98R83 Ribose-phosphate pyrophosphokinase [Mycoplasmopsis pulmoni... 82.0 4e-21
Q7U7L5 Ribose-phosphate pyrophosphokinase [Parasynechococcus mare... 78.2 1e-19
O52958 Ribose-phosphate pyrophosphokinase [Thermococcus kodakaren... 75.9 4e-19
Q9UY08 Ribose-phosphate pyrophosphokinase [Pyrococcus abyssi (str... 75.9 4e-19
Q7V6S2 Ribose-phosphate pyrophosphokinase [Prochlorococcus marinu... 74.7 2e-18
O59586 Ribose-phosphate pyrophosphokinase [Pyrococcus horikoshii ... 71.2 2e-17
Q8FQV2 Ribose-phosphate pyrophosphokinase [Corynebacterium effici... 71.6 2e-17
Q7VBH4 Ribose-phosphate pyrophosphokinase [Prochlorococcus marinu... 71.6 2e-17
Q8YN97 Ribose-phosphate pyrophosphokinase [Nostoc sp. (strain PCC... 68.6 2e-16
P38063 Ribose-phosphate pyrophosphokinase 4 [Saccharomyces cerevi... 65.5 2e-15
P09330 Ribose-phosphate pyrophosphokinase 2 [Rattus norvegicus] 63.9 7e-15
P11908 Ribose-phosphate pyrophosphokinase 2 [Homo sapiens] 63.5 1e-14
P38620 Ribose-phosphate pyrophosphokinase 2 [Saccharomyces cerevi... 63.2 1e-14
P9WKE3 Ribose-phosphate pyrophosphokinase [Mycobacterium tubercul... 63.2 1e-14
Q59988 Ribose-phosphate pyrophosphokinase [Synechococcus elongatu... 62.8 2e-14
P60891 Ribose-phosphate pyrophosphokinase 1 [Homo sapiens] 61.6 4e-14
P60892 Ribose-phosphate pyrophosphokinase 1 [Rattus norvegicus] 61.6 4e-14
Q9D7G0 Ribose-phosphate pyrophosphokinase 1 [Mus musculus] 61.6 4e-14
P14193 Ribose-phosphate pyrophosphokinase [Bacillus subtilis (str... 61.2 6e-14
P38689 Ribose-phosphate pyrophosphokinase 3 [Saccharomyces cerevi... 61.2 6e-14
P21108 Ribose-phosphate pyrophosphokinase 3 [Homo sapiens] 60.8 8e-14
>Q8U458 Ribose-phosphate pyrophosphokinase [Pyrococcus furiosus
(strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)]
Length=279
Score = 81.6 bits (200), Expect = 3e-21
Identities = 71/277 (26%), Positives = 128/277 (46%), Gaps = 37/277 (13%)
Query 13 NIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDIL-DYLLLENVLIQHR-KNIE 70
N+E +F GE++V++ L+ + V++ D+ L + LLL + L ++ + ++
Sbjct 23 NVEIKKFPDGEKYVRI----LEKGDKAIVVQSTYKPQDEFLIEALLLGDALRENGYRKLK 78
Query 71 VEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNG 130
+ IPY Y+RQDRV G+ S+ +L + ++ + + D H+ + G
Sbjct 79 IVIPYMAYSRQDRVTKEGEPISIRAVLKMLGLYYDE-------LYVMDIHNPKTLEFFPG 131
Query 131 YSSHLDLYQVEPVEIIKTSPALTELLQQQ--HTVLVCPDRGAKARTAAIAQYFNPKRSQQ 188
+ E I S + E + +++ PD+GA R AIA+ + S
Sbjct 132 RA-----------ENILPSKEIAEYFSDKLGEGIILAPDKGALERAKAIAEILGLEYS-- 178
Query 189 IAIIHCDKTR-EPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEH 247
H +K R PT ++T + + GK +I DDI G T I + LRKL E
Sbjct 179 ----HFEKKRISPTEVQMTPVNI---DVKGKNVLIVDDIISTGGTMIKATEILRKLGAEK 231
Query 248 IILYVTHGIFSRG-LDVFDGLIDQIFTSNSRPQQFHK 283
+ + THG+F+ G ++ +D++ +N+ P K
Sbjct 232 VFVAATHGVFAEGAIERLSKAVDELAVTNTIPTPVSK 268
Score = 17.3 bits (33), Expect = 9.6
Identities = 14/52 (27%), Positives = 20/52 (38%), Gaps = 0/52 (0%)
Query 234 IGIAKELRKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNL 285
I I L+ L + LYV + L+ F G + I S + F L
Sbjct 99 ISIRAVLKMLGLYYDELYVMDIHNPKTLEFFPGRAENILPSKEIAEYFSDKL 150
>Q98R83 Ribose-phosphate pyrophosphokinase [Mycoplasmopsis pulmonis
(strain UAB CTIP)]
Length=321
Score = 82.0 bits (201), Expect = 4e-21
Identities = 69/234 (29%), Positives = 112/234 (48%), Gaps = 28/234 (12%)
Query 48 SSDDILDYLLLENVLIQ-HRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEK 106
++++I+D L+ + L + K I V + Y+ YARQDR Q + + LL +
Sbjct 65 ANNNIMDLLIFVDSLKRASAKTINVILSYYGYARQDRKAEGRQPIAAKLLADLLQV---- 120
Query 107 HTSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTE--LLQQQHTVLV 164
+ RI + D H+ I N PV+ IK L++ ++ + +V
Sbjct 121 --AGISRIVVVDLHNPSIQGFFN-----------IPVDDIKAQYILSKEFTIKDEKFTIV 167
Query 165 CPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITD 224
PD G R +A+ + +IAII DK R T V+ G + + AVI D
Sbjct 168 SPDHGGTIRARIMAEIIS--NDVKIAII--DKRRVSTNKTEVLGVI--GDINNENAVIVD 221
Query 225 DICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGLDVFD--GLIDQIFTSNS 276
DI D G T + A+ L+K + I + +HGIFS+G D+F+ +ID++ +NS
Sbjct 222 DIIDTGGTIVNAAEVLKKNGAKKISIVASHGIFSKGFDIFEDADVIDEVIVTNS 275
>Q7U7L5 Ribose-phosphate pyrophosphokinase [Parasynechococcus
marenigrum (strain WH8102)]
Length=331
Score = 78.2 bits (191), Expect = 1e-19
Identities = 77/284 (27%), Positives = 130/284 (46%), Gaps = 34/284 (12%)
Query 18 QFSGGERHVQLSSQLLDTLGNTVRVR-AELNSSDDILDYLLLENVLIQ-HRKNIEVEIPY 75
+F+ GE +VQ+ + ++ A +N D +++ L++ + + + I +PY
Sbjct 52 RFADGELYVQIQESIRGCDVFLIQPTCAPVN--DHLMELLIMVDACRRASARQITAVVPY 109
Query 76 FPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHL 135
+ YAR DR A ++ + + +LL S R+ D HS I +
Sbjct 110 YGYARADRKTAGRESITAKLTANLLV------KSGVDRVLAMDLHSAQI-------QGYF 156
Query 136 DLYQVEPVEIIKTSPALTELLQQQHT---VLVCPDRGAKARTAAIAQYFNPKRSQQIAII 192
D+ P + I SP L + L Q+ V+V PD G AR A A+ N +AII
Sbjct 157 DI----PCDHIYGSPVLVDYLSTQNLDDIVVVSPDVGGVARARAFAKQMN---DAPLAII 209
Query 193 HCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHIILYV 252
DK R T + S+ G ++G+TA++ DD+ D G T A+ LR+ + +I
Sbjct 210 --DKRR--TGHNLAESLTVIGDVSGRTAILIDDMIDTGGTICAGARLLRQQGAKRVIACA 265
Query 253 THGIFSRGLD---VFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI 293
TH +FS DGL +Q+ +NS P Q + ++ ++
Sbjct 266 THAVFSPPASERLSADGLFEQVVVTNSIPIQQERTFPQLQVLSV 309
>O52958 Ribose-phosphate pyrophosphokinase [Thermococcus kodakarensis
(strain ATCC BAA-918 / JCM 12380 / KOD1)]
Length=280
Score = 75.9 bits (185), Expect = 4e-19
Identities = 71/278 (26%), Positives = 130/278 (47%), Gaps = 47/278 (17%)
Query 12 VNIEFIQFSGGERHVQLSSQLLDTLGN----TVRVRAELNSSDDILDYLLLENVLIQHR- 66
+ +E +F GE++V++ +GN TV + I++ LLL + L +
Sbjct 23 LEVEIKRFPDGEKYVRV-------MGNGDEATVVSSTFYPQDEKIVELLLLGDALREKGF 75
Query 67 KNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQ 126
+ +++ +PYF Y+RQDRV G+ S+ L I E+ + ++D H+
Sbjct 76 EKLKLVVPYFAYSRQDRVTKDGEPISVRAVMRALGIYYEE-------LYIFDTHNP---- 124
Query 127 LLNGYSSHLDLYQVEPVEIIKTSPA--LTELLQQQ--HTVLVCPDRGAKARTAAIAQYFN 182
+ + P + + SPA + E +++ +++ PD+GA R A+A+
Sbjct 125 ---------ETLRFFPGKAVNVSPARVIGEYFREKLGDGLVLAPDKGALERARAVAEVLG 175
Query 183 PKRSQQIAIIHCDKTR-EPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELR 241
+ S H +K R PT ++ V + GK +I DDI G T + A+ LR
Sbjct 176 LEYS------HFEKRRISPTEVEMHPVDV---DVKGKNVLIVDDIISTGGTMVRAAELLR 226
Query 242 KLQCEHIILYVTHGIFSRG-LDVFDGLIDQIFTSNSRP 278
KL + I + THG+F+ G ++ +D++ +N+ P
Sbjct 227 KLGAKKIYVSATHGVFAEGAIERVSRAVDELAVTNTIP 264
>Q9UY08 Ribose-phosphate pyrophosphokinase [Pyrococcus abyssi
(strain GE5 / Orsay)]
Length=285
Score = 75.9 bits (185), Expect = 4e-19
Identities = 69/285 (24%), Positives = 136/285 (48%), Gaps = 38/285 (13%)
Query 12 VNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDD-ILDYLLLENVLIQHR-KNI 69
+N+E +F GE++V++ L+ + +++ + D+ +++ LLL + L + K +
Sbjct 25 INVEIKKFPDGEKYVRV----LERGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKL 80
Query 70 EVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLN 129
++ IPY Y+RQDRV G+ S+ +L + ++ + ++D H+ +
Sbjct 81 KIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDE-------LYVFDIHNPKTLEHFP 133
Query 130 GYSSHLDLYQVEPVEIIKT--SPALTELLQQQHTVLVCPDRGAKARTAAIAQYFNPKRSQ 187
G + + + P E I L E L ++ PD+GA R +A+ + S
Sbjct 134 GIAKN-----IYPAEAIANYFKDKLGEGL------ILAPDKGALERAKRVAEVLGLEYS- 181
Query 188 QIAIIHCDKTR-EPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCE 246
H +K R PT ++ V GK +I DDI G T I A LR+L +
Sbjct 182 -----HFEKERISPTEVRMKPVDVDVN---GKNVLIVDDIISTGGTMIKAANILRELGAK 233
Query 247 HIILYVTHGIFSRG-LDVFDGLIDQIFTSNSRPQQFHKNLNVIEF 290
I + THG+F+ G ++ ++++ +N+ P + K ++++++
Sbjct 234 EIFVVATHGVFAEGAIERVSKAVNELAVTNTIPTEVSK-ISIVDY 277
>Q7V6S2 Ribose-phosphate pyrophosphokinase [Prochlorococcus marinus
(strain MIT 9313)]
Length=332
Score = 74.7 bits (182), Expect = 2e-18
Identities = 75/269 (28%), Positives = 124/269 (46%), Gaps = 34/269 (13%)
Query 18 QFSGGERHVQLSSQLLDTLGNTVRVR-AELNSSDDILDYLLLENVLIQ-HRKNIEVEIPY 75
+F+ GE +VQ+ + ++ A +N D++++ L++ + + + I +PY
Sbjct 52 RFADGELYVQIQESIRGCDVFLIQPTCAPVN--DNLMELLIMVDACQRASARQITAVVPY 109
Query 76 FPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHL 135
+ YAR DR A ++ + + +LL S R+ D HS I +
Sbjct 110 YGYARADRKTAGRESITAKLTANLLV------KSGVNRVLAMDLHSAQI-------QGYF 156
Query 136 DLYQVEPVEIIKTSPALTELLQQQH---TVLVCPDRGAKARTAAIAQYFNPKRSQQIAII 192
D+ P + I SP L + L Q V+V PD G AR A A+ R +AII
Sbjct 157 DI----PCDHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQM---RDAPLAII 209
Query 193 HCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHIILYV 252
DK R + + S+ G +AGKTA++ DD+ D G T A+ LR+ + +I
Sbjct 210 --DKRR--SGHNVAESLTVIGDVAGKTAILIDDMIDTGGTICSGARLLRQQGAKRVIACA 265
Query 253 THGIFSRGLD---VFDGLIDQIFTSNSRP 278
+H +FS +GL +Q+ +NS P
Sbjct 266 SHAVFSPPACERLSEEGLFEQVLVTNSIP 294
>O59586 Ribose-phosphate pyrophosphokinase [Pyrococcus horikoshii
(strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139
/ OT-3)]
Length=287
Score = 71.2 bits (173), Expect = 2e-17
Identities = 64/275 (23%), Positives = 129/275 (47%), Gaps = 37/275 (13%)
Query 15 EFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDD-ILDYLLLENVLIQHR-KNIEVE 72
E +F GE++V++ L+ + V++ D+ +++ +++ + L + + +++
Sbjct 28 EIKKFPDGEKYVRI----LEHGEEVIVVQSTYRPQDEHLIETIIIGDALKEAGFEKLKLV 83
Query 73 IPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYS 132
+PY Y+RQDRV G+ S+ +L + ++ + ++D H+
Sbjct 84 VPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDE-------LYVFDIHN----------P 126
Query 133 SHLDLYQVEPVEIIKTSPALTELLQQ--QHTVLVCPDRGAKARTAAIAQYFNPKRSQQIA 190
LD + + V I + E + ++ +++ PDRGA R +A + S
Sbjct 127 KTLDFFPGKAVNIYPAK-VIAEYFRDKLENGLVLAPDRGALERAKEVANILGLEYS---- 181
Query 191 IIHCDKTR-EPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHII 249
H +K R PT K+T V ++ G+ +I DDI G T I A+ L+ L E +
Sbjct 182 --HFEKERISPTEVKMTPVDV---NVKGRNVLIVDDIISTGGTMIRAAEILKDLGAEKVF 236
Query 250 LYVTHGIFSRG-LDVFDGLIDQIFTSNSRPQQFHK 283
+ THG+F+ G ++ +D++ +N+ P + K
Sbjct 237 VVATHGVFAEGAIERVSKAVDELAVTNTIPTKVSK 271
>Q8FQV2 Ribose-phosphate pyrophosphokinase [Corynebacterium efficiens
(strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 /
NBRC 100395)]
Length=325
Score = 71.6 bits (174), Expect = 2e-17
Identities = 56/212 (26%), Positives = 97/212 (46%), Gaps = 27/212 (13%)
Query 52 ILDYLLLENVLIQ-HRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSI 110
+++ LL+ + L + K I +P++PYARQD+ + S + LL T+
Sbjct 75 LMEQLLMIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLIADLLQ------TAG 128
Query 111 RRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT----VLVCP 166
RI D H++ I +G PV+ + P LT+ ++ ++ V+V P
Sbjct 129 ADRIVSVDLHTDQIQGFFDG-----------PVDHMHAMPILTDYIKDKYDLSNIVVVSP 177
Query 167 DRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDI 226
D G R ++ N +A +H ++ E + + VV G +AGK V+ DD+
Sbjct 178 DAG---RVKVAEKWANTLGDAPMAFVHKTRSTEVANEVVANRVV--GDVAGKDCVLLDDM 232
Query 227 CDGGATFIGIAKELRKLQCEHIILYVTHGIFS 258
D G T G L++ +++ THG+FS
Sbjct 233 IDTGGTIAGAVGVLKEAGARSVVIACTHGVFS 264
>Q7VBH4 Ribose-phosphate pyrophosphokinase [Prochlorococcus marinus
(strain SARG / CCMP1375 / SS120)]
Length=327
Score = 71.6 bits (174), Expect = 2e-17
Identities = 78/297 (26%), Positives = 134/297 (45%), Gaps = 37/297 (12%)
Query 3 IQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVR-AELNSSDDILDYLLLENV 61
I +I + V + +F+ GE +VQ+ + ++ A +N D +++ +++ +
Sbjct 33 ISSYIGIEDVPVVSKRFADGELYVQIQQSIRGCDVFLIQPTCAPVN--DSLMELMIMVDA 90
Query 62 LIQ-HRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAH 120
+ + + IPYF YAR DR A ++ + + +LL +S R+ D H
Sbjct 91 CKRASARQVTAVIPYFGYARADRKTAGRESITAKLTANLLV------SSGVDRVLAMDLH 144
Query 121 SNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT---VLVCPDRGAKARTAAI 177
S I + D+ P + I SP L + L ++ V+V PD G AR A
Sbjct 145 SAQI-------QGYFDI----PCDHIYGSPVLIDYLSTKNLDEIVVVSPDVGGVARARAF 193
Query 178 AQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIA 237
A+ + +AII DK R + S+ G +A KTA++ DD+ D G T A
Sbjct 194 AKQM---KDSPLAII--DKRR--AAHNVAQSLTVIGDVANKTAILIDDMIDTGGTICAGA 246
Query 238 KELRKLQCEHIILYVTHGIFS---RGLDVFDGLIDQIFTSNSRP---QQFHKNLNVI 288
+ LRK + +I +H +FS D L +++ +NS P Q+ + L V+
Sbjct 247 ELLRKEGAKRVIACASHAVFSPPAYSRLSADDLFEEVVVTNSIPVPTSQYFEQLKVL 303
>Q8YN97 Ribose-phosphate pyrophosphokinase [Nostoc sp. (strain
PCC 7120 / SAG 25.82 / UTEX 2576)]
Length=330
Score = 68.6 bits (166), Expect = 2e-16
Identities = 68/267 (25%), Positives = 119/267 (45%), Gaps = 31/267 (12%)
Query 18 QFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLENVLIQ-HRKNIEVEIPYF 76
+F+ GE +VQ+ + ++ + +D +++ L++ + + + + IPY+
Sbjct 52 RFADGELYVQIQESIRGCDVYLIQPCCQ-PVNDHLMELLIMVDACRRASARQVTAVIPYY 110
Query 77 PYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHLD 136
YAR DR A ++ + + +L+ + R+ D H+ I + D
Sbjct 111 GYARADRKTAGRESITAKLVANLIT------QAGANRVLAMDLHAAQI-------QGYFD 157
Query 137 LYQVEPVEIIKTSPALTELL---QQQHTVLVCPDRGAKARTAAIAQYFNPKRSQQIAIIH 193
+ P + + SP L + L Q V+V PD G AR A A+ N +AII
Sbjct 158 I----PFDHVYGSPVLLDYLTSKQLHDIVVVSPDVGGVARARAFAKKLN---DAPLAII- 209
Query 194 CDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHIILYVT 253
DK R+ +V+ G + GKTAV+ DD+ D G T AK LR+ + T
Sbjct 210 -DKRRQAHNVAEVLNVI--GDVKGKTAVLVDDMIDTGGTIAAGAKLLREEGARQVYACAT 266
Query 254 HGIFSRGL--DVFDGLIDQIFTSNSRP 278
H +FS + GL +++ +N+ P
Sbjct 267 HAVFSPPAVERLSSGLFEEVIVTNTIP 293
>P38063 Ribose-phosphate pyrophosphokinase 4 [Saccharomyces cerevisiae
(strain ATCC 204508 / S288c)]
Length=326
Score = 65.5 bits (158), Expect = 2e-15
Identities = 64/247 (26%), Positives = 106/247 (43%), Gaps = 31/247 (13%)
Query 18 QFSGGERHVQLSSQLLDTLGNTVRVR-AELNSSDDILDYLLLENVL-IQHRKNIEVEIPY 75
Q+S E V + L D ++ E +D +++ L+L + I + I IP
Sbjct 44 QYSNKETSVTIGESLRDEDVYIIQTGIGEQEINDFLMELLILIHACKIASARKITTVIPN 103
Query 76 FPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHL 135
FPYARQD+ + + + +LL H IT+ D H++ I H+
Sbjct 104 FPYARQDKKDKSRAPITAKLVANLLQTAGADHV-----ITM-DLHASQIQGFF-----HI 152
Query 136 DLYQVEPVEIIKTSPALTELLQQQ----HTVLVCPDRGAKARTAAIAQYFNPKRSQQIAI 191
PV+ + P++ ++ + + +LV PD G R AA+A K A+
Sbjct 153 ------PVDNLYAEPSVLNYIRTKTDFDNAILVSPDAGGAKRVAALAD----KLDLNFAL 202
Query 192 IHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHIILY 251
IH +E S +V G + K+ ++ DD+ D T + L + + +I
Sbjct 203 IH----KERQKANEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIAI 258
Query 252 VTHGIFS 258
VTHGIFS
Sbjct 259 VTHGIFS 265
>P09330 Ribose-phosphate pyrophosphokinase 2 [Rattus norvegicus]
Length=318
Score = 63.9 bits (154), Expect = 7e-15
Identities = 55/240 (23%), Positives = 105/240 (44%), Gaps = 33/240 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D++++ L++ N I + IP FPYARQD+ + S + ++L++ H
Sbjct 64 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT-----V 162
I D H++ I D+ PV+ + PA+ + +++ T +
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPAVLQWIRENITEWRNCI 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N + A+IH ++ + ++ V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADRLNV----EFALIHKERKKANEVDRM----VLVGDVKDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGL--DVFDGLIDQIFTSNSRPQQ 280
DD+ D T A +L + +THGIFS + + + + +N+ PQ+
Sbjct 219 VDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQE 278
>P11908 Ribose-phosphate pyrophosphokinase 2 [Homo sapiens]
Length=318
Score = 63.5 bits (153), Expect = 1e-14
Identities = 54/240 (23%), Positives = 106/240 (44%), Gaps = 33/240 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D++++ L++ N I + IP FPYARQD+ + S + ++L++ H
Sbjct 64 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQ-----QHTV 162
I D H++ I D+ PV+ + PA+ + +++ ++ +
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPAVLQWIRENIAEWKNCI 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N + A+IH ++ + ++ V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADRLNV----EFALIHKERKKANEVDRM----VLVGDVKDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGL--DVFDGLIDQIFTSNSRPQQ 280
DD+ D T A +L + +THGIFS + + + + +N+ PQ+
Sbjct 219 VDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQE 278
>P38620 Ribose-phosphate pyrophosphokinase 2 [Saccharomyces cerevisiae
(strain ATCC 204508 / S288c)]
Length=318
Score = 63.2 bits (152), Expect = 1e-14
Identities = 63/250 (25%), Positives = 104/250 (42%), Gaps = 37/250 (15%)
Query 18 QFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLENVLIQHRKNIEVE----- 72
Q+S E V + + D V + +I D+L+ +LI K V
Sbjct 36 QYSNKETSVTIGESIRD---EDVYIIQTGYGEHEINDFLMELLILIHACKTASVRRITAV 92
Query 73 IPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYS 132
IP FPYARQD+ + + + +LL T+ + D H++ I
Sbjct 93 IPNFPYARQDKKDKSRAPITAKLIANLLE------TAGCDHVITMDLHASQIQGFF---- 142
Query 133 SHLDLYQVEPVEIIKTSPALTELLQQQ----HTVLVCPDRGAKARTAAIAQYFNPKRSQQ 188
H+ PV+ + P++ ++ + + +LV PD G R A++A K
Sbjct 143 -HI------PVDNLYGEPSVLNYIRTKTDFNNAILVSPDAGGAKRVASLAD----KLDMN 191
Query 189 IAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKLQCEHI 248
A+IH +E S ++ G +AGK+ ++ DD+ D T + L + +
Sbjct 192 FALIH----KERQKANEVSRMLLVGDVAGKSCLLIDDMADTCGTLVKACDTLMDHGAKEV 247
Query 249 ILYVTHGIFS 258
I VTHGIFS
Sbjct 248 IAIVTHGIFS 257
>P9WKE3 Ribose-phosphate pyrophosphokinase [Mycobacterium tuberculosis
(strain ATCC 25618 / H37Rv)]
Length=326
Score = 63.2 bits (152), Expect = 1e-14
Identities = 54/196 (28%), Positives = 83/196 (42%), Gaps = 26/196 (13%)
Query 67 KNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQ 126
K I +P++PYARQD+ + S + LL T+ RI D H++ I
Sbjct 91 KRITAVMPFYPYARQDKKHRGREPISARLIADLLK------TAGADRIVTVDLHTDQIQG 144
Query 127 LLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT----VLVCPDRGAKARTAAIAQYFN 182
+G PV+ ++ LT ++ + V+V PD G R ++ +
Sbjct 145 FFDG-----------PVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSG---RVRIAEKWAD 190
Query 183 PKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRK 242
+A IH KTR+P S G +AG+T V+ DD+ D G T G L
Sbjct 191 ALGGVPLAFIH--KTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHN 248
Query 243 LQCEHIILYVTHGIFS 258
+I+ THG+ S
Sbjct 249 DGAGDVIIAATHGVLS 264
>Q59988 Ribose-phosphate pyrophosphokinase [Synechococcus elongatus
(strain ATCC 33912 / PCC 7942 / FACHB-805)]
Length=331
Score = 62.8 bits (151), Expect = 2e-14
Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 32/219 (15%)
Query 67 KNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQ 126
+ I +PY+ YAR DR A ++ + + +L+ + R+ D HS I
Sbjct 101 RQITAVLPYYGYARADRKTAGRESITAKLVANLIT------QAGANRVLAMDLHSAQI-- 152
Query 127 LLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT---VLVCPDRGAKARTAAIAQYFNP 183
+ D+ P + + SP L + L+ ++ V+V PD G AR A A+ +
Sbjct 153 -----QGYFDI----PFDHVYGSPVLIDYLRSKNLADLVVVSPDVGGVARARAFAKKLD- 202
Query 184 KRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELRKL 243
+AII DK R+ +V+ G + GKTAV+ DD+ D T A+ LRK
Sbjct 203 --DAPLAII--DKRRQAHNVAEVLNVI--GDVQGKTAVLVDDMIDTAGTICEGARLLRKQ 256
Query 244 QCEHIILYVTHGIFS----RGLDVFDGLIDQIFTSNSRP 278
+ TH +FS L GL +++ +N+ P
Sbjct 257 GASQVYACATHAVFSPPAIERLSA-SGLFEEVIVTNTIP 294
>P60891 Ribose-phosphate pyrophosphokinase 1 [Homo sapiens]
Length=318
Score = 61.6 bits (148), Expect = 4e-14
Identities = 54/240 (23%), Positives = 104/240 (43%), Gaps = 33/240 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D++++ L++ N I + IP FPYARQD+ + S + ++L++ H
Sbjct 64 NDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQ-----QHTV 162
I D H++ I D+ PV+ + PA+ + +++ ++
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPAVLKWIRENISEWRNCT 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N A+IH ++ + ++ V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADRLNV----DFALIHKERKKANEVDRM----VLVGDVKDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGL--DVFDGLIDQIFTSNSRPQQ 280
DD+ D T A +L + +THGIFS + + + + +N+ PQ+
Sbjct 219 VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQE 278
>P60892 Ribose-phosphate pyrophosphokinase 1 [Rattus norvegicus]
Length=318
Score = 61.6 bits (148), Expect = 4e-14
Identities = 54/240 (23%), Positives = 104/240 (43%), Gaps = 33/240 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D++++ L++ N I + IP FPYARQD+ + S + ++L++ H
Sbjct 64 NDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQ-----QHTV 162
I D H++ I D+ PV+ + PA+ + +++ ++
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPAVLKWIRENISEWRNCT 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N A+IH ++ + ++ V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADRLNV----DFALIHKERKKANEVDRM----VLVGDVKDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGL--DVFDGLIDQIFTSNSRPQQ 280
DD+ D T A +L + +THGIFS + + + + +N+ PQ+
Sbjct 219 VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQE 278
>Q9D7G0 Ribose-phosphate pyrophosphokinase 1 [Mus musculus]
Length=318
Score = 61.6 bits (148), Expect = 4e-14
Identities = 54/240 (23%), Positives = 104/240 (43%), Gaps = 33/240 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D++++ L++ N I + IP FPYARQD+ + S + ++L++ H
Sbjct 64 NDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQ-----QHTV 162
I D H++ I D+ PV+ + PA+ + +++ ++
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPAVLKWIRENISEWRNCT 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N A+IH ++ + ++ V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADRLNV----DFALIHKERKKANEVDRM----VLVGDVKDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFSRGL--DVFDGLIDQIFTSNSRPQQ 280
DD+ D T A +L + +THGIFS + + + + +N+ PQ+
Sbjct 219 VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQE 278
>P14193 Ribose-phosphate pyrophosphokinase [Bacillus subtilis
(strain 168)]
Length=317
Score = 61.2 bits (147), Expect = 6e-14
Identities = 58/215 (27%), Positives = 97/215 (45%), Gaps = 31/215 (14%)
Query 49 SDDILDYLLLENVLIQ-HRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
++ I++ L++ + L + K I + IPY+ YARQDR + + + +F +LL
Sbjct 70 NEHIMELLIMVDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLFANLL------E 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQH---TVLV 164
T+ R+ D H+ I D+ P++ + P L E + ++ V+V
Sbjct 124 TAGATRVIALDLHAPQI-------QGFFDI----PIDHLMGVPILGEYFEGKNLEDIVIV 172
Query 165 CPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTR-EPTTGKITSSVVKTGSLAGKTAVIT 223
PD G R +A + IAII DK R P ++ + V G++ GKTA++
Sbjct 173 SPDHGGVTRARKLAD----RLKAPIAII--DKRRPRPNVAEVMNIV---GNIEGKTAILI 223
Query 224 DDICDGGATFIGIAKELRKLQCEHIILYVTHGIFS 258
DDI D T A L + + + TH + S
Sbjct 224 DDIIDTAGTITLAANALVENGAKEVYACCTHPVLS 258
>P38689 Ribose-phosphate pyrophosphokinase 3 [Saccharomyces cerevisiae
(strain ATCC 204508 / S288c)]
Length=320
Score = 61.2 bits (147), Expect = 6e-14
Identities = 58/235 (25%), Positives = 104/235 (44%), Gaps = 28/235 (12%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D +L+ L++ N + I IP FPYARQDR + + + +L
Sbjct 67 NDRVLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLT------ 120
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEP--VEIIKTSPALTELLQQQHTVLVC 165
T+ + D H++ Q+ + +D EP V IK E + ++++
Sbjct 121 TAGCDHVITMDLHAS---QIQGFFDVPVDNLYAEPSVVRYIK------ENVNYMDSIIIS 171
Query 166 PDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDD 225
PD G R A +A + A+IH ++ R S +V G + K +I DD
Sbjct 172 PDAGGAKRAATLAD----RLDLNFALIHKERAR----ANEVSRMVLVGDVTDKICIIVDD 223
Query 226 ICDGGATFIGIAKELRKLQCEHIILYVTHGIFS-RGLD-VFDGLIDQIFTSNSRP 278
+ D T A+ L + + + +I VTHG+ S R ++ + + +D++ +N+ P
Sbjct 224 MADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKLDRVVCTNTVP 278
Score = 23.1 bits (48), Expect = 0.14
Identities = 13/54 (24%), Positives = 25/54 (46%), Gaps = 2/54 (4%)
Query 236 IAKELRKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIE 289
+A L C+H+I H +G FD +D ++ S + +N+N ++
Sbjct 115 MADMLTTAGCDHVITMDLHASQIQGF--FDVPVDNLYAEPSVVRYIKENVNYMD 166
>P21108 Ribose-phosphate pyrophosphokinase 3 [Homo sapiens]
Length=318
Score = 60.8 bits (146), Expect = 8e-14
Identities = 52/216 (24%), Positives = 91/216 (42%), Gaps = 31/216 (14%)
Query 49 SDDILDYLLLENVL-IQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKH 107
+D +++ L++ N I + IP FPYARQD+ + S + ++L+I H
Sbjct 64 NDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAGADH 123
Query 108 TSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQ-----QHTV 162
I D H++ I D+ PV+ + P + + +++ ++ +
Sbjct 124 ------IITMDLHASQI-------QGFFDI----PVDNLYAEPTVLKWIRENIPEWKNCI 166
Query 163 LVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVI 222
+V PD G R +IA N A+IH +E +V G + + A++
Sbjct 167 IVSPDAGGAKRVTSIADQLNV----DFALIH----KERKKANEVDCIVLVGDVNDRVAIL 218
Query 223 TDDICDGGATFIGIAKELRKLQCEHIILYVTHGIFS 258
DD+ D T A +L + +THGIFS
Sbjct 219 VDDMADTCVTICLAADKLLSAGATRVYAILTHGIFS 254
Lambda K H a alpha
0.325 0.139 0.406 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1448202
Database: 22dd2775dd2b5c0e3a30ea390dd492e2.SwissProt.fasta
Posted date: May 9, 2024 4:43 AM
Number of letters in database: 6,943
Number of sequences in database: 22
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
