Comparative Genomics

ACIAD0989 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 133c47877461e6978cb74f3d87910052.SwissProt.fasta
           20 sequences; 5,048 total letters



Query= ACIAD0989

Length=257
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q9X248 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Thermotog...  135     3e-42
Q988B7 Pyridoxal 4-dehydrogenase [Mesorhizobium japonicum (strain...  135     3e-42
P66782 Uncharacterized oxidoreductase Mb1385 [Mycobacterium bovis...  135     4e-42
P9WGR9 Uncharacterized oxidoreductase Rv1350 [Mycobacterium tuber...  135     4e-42
P9WGR8 Uncharacterized oxidoreductase MT1393 [Mycobacterium tuber...  135     4e-42
P69166 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobac...  131     1e-40
P9WGT1 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobac...  131     1e-40
P9WGT0 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobac...  131     2e-40
P9WGQ9 Uncharacterized oxidoreductase Rv0769 [Mycobacterium tuber...  129     7e-40
P9WGQ8 Uncharacterized oxidoreductase MT0793 [Mycobacterium tuber...  129     7e-40
P51831 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Bacillus ...  128     2e-39
P0A9Q0 5-keto-D-gluconate 5-reductase [Escherichia coli O6:H1 (st...  128     2e-39
P0A9P9 5-keto-D-gluconate 5-reductase [Escherichia coli (strain K...  128     2e-39
Q8WNV7 Dehydrogenase/reductase SDR family member 4 [Sus scrofa]       127     6e-39
Q92EU6 NAD-dependent glycerol dehydrogenase [Listeria innocua ser...  126     9e-39
A7IQH5 2-(S)-hydroxypropyl-CoM dehydrogenase 3 [Xanthobacter auto...  126     1e-38
Q937L4 Cyclopentanol dehydrogenase [Comamonas testosteroni]           125     2e-38
Q8GAV9 Cyclopentanol dehydrogenase [Comamonas sp. (strain NCIMB 9...  125     2e-38
Q5P5I4 (S)-1-Phenylethanol dehydrogenase [Aromatoleum aromaticum ...  124     5e-38
P99093 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Staphyloc...  122     2e-37


>Q9X248 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Thermotoga 
maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 
100826 / MSB8)]
Length=246

 Score = 135 bits (340),  Expect = 3e-42
 Identities = 79/246 (32%), Positives = 134/246 (54%), Gaps = 3/246 (1%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK  ++TGAA G+G       A+ GA VI  DI  E ++   K+ +    +V    L+
Sbjct  3    LEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLN  62

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++  + I+  V+  V  +G +D LVN A +        L +   + WD V+ VN+KG + 
Sbjct  63   VTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDAL---LVRMKEEDWDAVINVNLKGVFN  119

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
            + Q  VPY+ + ++  I+N++S   ++G P    Y ASK  ++ MT++ A+EL   NI V
Sbjct  120  VTQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRV  179

Query  189  NTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQNIP  248
            N ++PG      TE +P++  +  ++   + R   P+++    L+L SD +S+VTGQ I 
Sbjct  180  NAVAPGFIETPMTEKLPEKARETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIG  239

Query  249  VNGGFV  254
            ++GG V
Sbjct  240  IDGGLV  245


>Q988B7 Pyridoxal 4-dehydrogenase [Mesorhizobium japonicum (strain 
LMG 29417 / CECT 9101 / MAFF 303099)]
Length=248

 Score = 135 bits (340),  Expect = 3e-42
 Identities = 83/248 (33%), Positives = 139/248 (56%), Gaps = 8/248 (3%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK  +VTGAA+G+G   A  +A  GA VI++DI  E  +  A  +   G + +A+  D
Sbjct  5    LAGKTALVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASI---GKKARAIAAD  61

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            +S P S++          GG+D LVN A++   V   D+   D D W +++ VN+ GT++
Sbjct  62   ISDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDV---DLDHWRKIIDVNLTGTFI  118

Query  129  MVQACVPYLKQSQSA-KIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNIC  187
            + +A    ++ +  A ++I+IAS+T   G P + AYVA+KG ++  TR++A ELG++NI 
Sbjct  119  VTRAGTDQMRAAGKAGRVISIASNTFFAGTPNMAAYVAAKGGVIGFTRALATELGKYNIT  178

Query  188  VNTLSPGLTLVEATEYVP-QERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
             N ++PGL   +  +  P  E        +A++ +  P+ +     +L SD A ++TGQ 
Sbjct  179  ANAVTPGLIESDGVKASPHNEAFGFVEMLQAMKGKGQPEHIADVVSFLASDDARWITGQT  238

Query  247  IPVNGGFV  254
            + V+ G V
Sbjct  239  LNVDAGMV  246


>P66782 Uncharacterized oxidoreductase Mb1385 [Mycobacterium bovis 
(strain ATCC BAA-935 / AF2122/97)]
Length=247

 Score = 135 bits (339),  Expect = 4e-42
 Identities = 77/246 (31%), Positives = 136/246 (55%), Gaps = 4/246 (2%)

Query  7    TLLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVG  66
            +LL+ +  ++TG A+GLGL   Q     GA+V++ D+ +E  E  AK+L    + + AV 
Sbjct  3    SLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGGDDVAL-AVR  61

Query  67   LDLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGT  126
             D++Q + +   ++ AV  +GGLD +VN A +      + +T+   + +D+V+ V++KGT
Sbjct  62   CDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE---EQFDQVIAVHLKGT  118

Query  127  WLMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNI  186
            W   +     +++ +   I+N++S +   G      Y A+K  I+ MT++ A+EL    I
Sbjct  119  WNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGI  178

Query  187  CVNTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
             VN ++PGL     TE +PQ   D  +    + R   P ++   A++L SDL+S++TG  
Sbjct  179  RVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTV  238

Query  247  IPVNGG  252
            + V GG
Sbjct  239  LDVTGG  244


>P9WGR9 Uncharacterized oxidoreductase Rv1350 [Mycobacterium tuberculosis 
(strain ATCC 25618 / H37Rv)]
Length=247

 Score = 135 bits (339),  Expect = 4e-42
 Identities = 77/246 (31%), Positives = 136/246 (55%), Gaps = 4/246 (2%)

Query  7    TLLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVG  66
            +LL+ +  ++TG A+GLGL   Q     GA+V++ D+ +E  E  AK+L    + + AV 
Sbjct  3    SLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGGDDVAL-AVR  61

Query  67   LDLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGT  126
             D++Q + +   ++ AV  +GGLD +VN A +      + +T+   + +D+V+ V++KGT
Sbjct  62   CDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE---EQFDQVIAVHLKGT  118

Query  127  WLMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNI  186
            W   +     +++ +   I+N++S +   G      Y A+K  I+ MT++ A+EL    I
Sbjct  119  WNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGI  178

Query  187  CVNTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
             VN ++PGL     TE +PQ   D  +    + R   P ++   A++L SDL+S++TG  
Sbjct  179  RVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTV  238

Query  247  IPVNGG  252
            + V GG
Sbjct  239  LDVTGG  244


>P9WGR8 Uncharacterized oxidoreductase MT1393 [Mycobacterium tuberculosis 
(strain CDC 1551 / Oshkosh)]
Length=247

 Score = 135 bits (339),  Expect = 4e-42
 Identities = 77/246 (31%), Positives = 136/246 (55%), Gaps = 4/246 (2%)

Query  7    TLLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVG  66
            +LL+ +  ++TG A+GLGL   Q     GA+V++ D+ +E  E  AK+L    + + AV 
Sbjct  3    SLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGGDDVAL-AVR  61

Query  67   LDLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGT  126
             D++Q + +   ++ AV  +GGLD +VN A +      + +T+   + +D+V+ V++KGT
Sbjct  62   CDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE---EQFDQVIAVHLKGT  118

Query  127  WLMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNI  186
            W   +     +++ +   I+N++S +   G      Y A+K  I+ MT++ A+EL    I
Sbjct  119  WNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGI  178

Query  187  CVNTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
             VN ++PGL     TE +PQ   D  +    + R   P ++   A++L SDL+S++TG  
Sbjct  179  RVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTV  238

Query  247  IPVNGG  252
            + V GG
Sbjct  239  LDVTGG  244


>P69166 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobacterium 
bovis (strain ATCC BAA-935 / AF2122/97)]
Length=260

 Score = 131 bits (330),  Expect = 1e-40
 Identities = 88/246 (36%), Positives = 132/246 (54%), Gaps = 11/246 (4%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK  +V+G ARG+G    +A+   GA+V+  DIL E  +  A +L      V    LD
Sbjct  5    LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVH---LD  61

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++QP     AV  AV  +GGL  LVN A +   +G   +  Y    W R++ VN+ G +L
Sbjct  62   VTQPAQWTAAVDTAVTAFGGLHVLVNNAGILN-IG--TIEDYALTEWQRILDVNLTGVFL  118

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
             ++A V  +K++    IINI+S   L G      Y A+K A+  +T+S A ELG   I V
Sbjct  119  GIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRV  178

Query  189  NTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQNIP  248
            N++ PGL     T++VP+   D++ T  A+ R   P +++   +YL SD +S+ TG    
Sbjct  179  NSIHPGLVKTPMTDWVPE---DIFQT--ALGRAAEPVEVSNLVVYLASDESSYSTGAEFV  233

Query  249  VNGGFV  254
            V+GG V
Sbjct  234  VDGGTV  239


>P9WGT1 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=260

 Score = 131 bits (330),  Expect = 1e-40
 Identities = 88/246 (36%), Positives = 132/246 (54%), Gaps = 11/246 (4%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK  +V+G ARG+G    +A+   GA+V+  DIL E  +  A +L      V    LD
Sbjct  5    LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVH---LD  61

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++QP     AV  AV  +GGL  LVN A +   +G   +  Y    W R++ VN+ G +L
Sbjct  62   VTQPAQWTAAVDTAVTAFGGLHVLVNNAGILN-IG--TIEDYALTEWQRILDVNLTGVFL  118

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
             ++A V  +K++    IINI+S   L G      Y A+K A+  +T+S A ELG   I V
Sbjct  119  GIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRV  178

Query  189  NTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQNIP  248
            N++ PGL     T++VP+   D++ T  A+ R   P +++   +YL SD +S+ TG    
Sbjct  179  NSIHPGLVKTPMTDWVPE---DIFQT--ALGRAAEPVEVSNLVVYLASDESSYSTGAEFV  233

Query  249  VNGGFV  254
            V+GG V
Sbjct  234  VDGGTV  239


>P9WGT0 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Mycobacterium 
tuberculosis (strain CDC 1551 / Oshkosh)]
Length=260

 Score = 131 bits (329),  Expect = 2e-40
 Identities = 88/246 (36%), Positives = 132/246 (54%), Gaps = 11/246 (4%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK  +V+G ARG+G    +A+   GA+V+  DIL E  +  A +L      V    LD
Sbjct  5    LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVH---LD  61

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++QP     AV  AV  +GGL  LVN A +   +G   +  Y    W R++ VN+ G +L
Sbjct  62   VTQPAQWTAAVDTAVTAFGGLHVLVNNAGILN-IG--TIEDYALTEWQRILDVNLTGVFL  118

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
             ++A V  +K++    IINI+S   L G      Y A+K A+  +T+S A ELG   I V
Sbjct  119  GIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPGGIRV  178

Query  189  NTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQNIP  248
            N++ PGL     T++VP+   D++ T  A+ R   P +++   +YL SD +S+ TG    
Sbjct  179  NSIHPGLVKTPMTDWVPE---DIFQT--ALGRAAEPVEVSNLVVYLASDESSYSTGAEFV  233

Query  249  VNGGFV  254
            V+GG V
Sbjct  234  VDGGTV  239


>P9WGQ9 Uncharacterized oxidoreductase Rv0769 [Mycobacterium tuberculosis 
(strain ATCC 25618 / H37Rv)]
Length=248

 Score = 129 bits (324),  Expect = 7e-40
 Identities = 89/246 (36%), Positives = 129/246 (52%), Gaps = 4/246 (2%)

Query  8    LLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGL  67
            +   K  IVTGAA+G+G  +AQA+A  GA V++ADI  +     AKQ+   G     V +
Sbjct  1    MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPV  60

Query  68   DLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTW  127
            D+S  +S +  V  AV  +GG+D LVN AA+  G+    L     D + + M+VN  G  
Sbjct  61   DVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVL  120

Query  128  LMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNIC  187
            +  +A   ++ +     I+N  S TA W       Y  +K  +  +T+ +ARELG   I 
Sbjct  121  VCTRAVYKHMAKRGGGAIVN-QSSTAAWLYSNF--YGLAKVGVNGLTQQLARELGGMKIR  177

Query  188  VNTLSPGLTLVEATEYV-PQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            +N ++PG    EAT  V P E     V    + R   P+DL G  L+LLSD AS++TGQ 
Sbjct  178  INAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQI  237

Query  247  IPVNGG  252
              V+GG
Sbjct  238  FNVDGG  243


>P9WGQ8 Uncharacterized oxidoreductase MT0793 [Mycobacterium tuberculosis 
(strain CDC 1551 / Oshkosh)]
Length=248

 Score = 129 bits (324),  Expect = 7e-40
 Identities = 89/246 (36%), Positives = 129/246 (52%), Gaps = 4/246 (2%)

Query  8    LLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGL  67
            +   K  IVTGAA+G+G  +AQA+A  GA V++ADI  +     AKQ+   G     V +
Sbjct  1    MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPV  60

Query  68   DLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTW  127
            D+S  +S +  V  AV  +GG+D LVN AA+  G+    L     D + + M+VN  G  
Sbjct  61   DVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVL  120

Query  128  LMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNIC  187
            +  +A   ++ +     I+N  S TA W       Y  +K  +  +T+ +ARELG   I 
Sbjct  121  VCTRAVYKHMAKRGGGAIVN-QSSTAAWLYSNF--YGLAKVGVNGLTQQLARELGGMKIR  177

Query  188  VNTLSPGLTLVEATEYV-PQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            +N ++PG    EAT  V P E     V    + R   P+DL G  L+LLSD AS++TGQ 
Sbjct  178  INAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQI  237

Query  247  IPVNGG  252
              V+GG
Sbjct  238  FNVDGG  243


>P51831 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Bacillus 
subtilis (strain 168)]
Length=246

 Score = 128 bits (321),  Expect = 2e-39
 Identities = 74/248 (30%), Positives = 134/248 (54%), Gaps = 4/248 (2%)

Query  8    LLHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEA-KQLQQQGLQVQAVG  66
            +L+ K  IVTGA+RG+G   A  +A++GA V++     E    E   +++  G +  AV 
Sbjct  1    MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANEVVDEIKSMGRKAIAVK  60

Query  67   LDLSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGT  126
             D+S PE +Q  ++  ++ +  +D LVN A +        + +   D WD V+ +N+KG 
Sbjct  61   ADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRD---NLIMRMKEDEWDDVININLKGV  117

Query  127  WLMVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNI  186
            +   +A    + + +S +IIN++S   + G P    YVA+K  ++ +T+S A+EL   NI
Sbjct  118  FNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAGVIGLTKSSAKELASRNI  177

Query  187  CVNTLSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
             VN ++PG    + T+ + ++  D  +    + R   P D++    +L S+ A ++TGQ 
Sbjct  178  TVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDVSSVVTFLASEGARYMTGQT  237

Query  247  IPVNGGFV  254
            + ++GG V
Sbjct  238  LHIDGGMV  245


>P0A9Q0 5-keto-D-gluconate 5-reductase [Escherichia coli O6:H1 
(strain CFT073 / ATCC 700928 / UPEC)]
Length=254

 Score = 128 bits (321),  Expect = 2e-39
 Identities = 82/248 (33%), Positives = 129/248 (52%), Gaps = 5/248 (2%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK I++TG+A+G+G   A  + + GAQ+I+ DI  E  E   ++L Q+G+Q  A   +
Sbjct  7    LAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFN  66

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++    I  AV+      G +D LVN A +         T++    W+ V+ VN    +L
Sbjct  67   VTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRR---HPFTEFPEQEWNDVIAVNQTAVFL  123

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
            + QA   ++ + ++ K+INI S  +  G   +  Y ASKGA+  +TR M  EL   NI V
Sbjct  124  VSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQV  183

Query  189  NTLSPGLTLVEATE-YVPQERHDLYVTGRA-IQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            N ++PG    E T+  V  E    ++  R    R   PQ+L G A++L S  + FV G  
Sbjct  184  NGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHL  243

Query  247  IPVNGGFV  254
            + V+GG +
Sbjct  244  LFVDGGML  251


>P0A9P9 5-keto-D-gluconate 5-reductase [Escherichia coli (strain 
K12)]
Length=254

 Score = 128 bits (321),  Expect = 2e-39
 Identities = 82/248 (33%), Positives = 129/248 (52%), Gaps = 5/248 (2%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L GK I++TG+A+G+G   A  + + GAQ+I+ DI  E  E   ++L Q+G+Q  A   +
Sbjct  7    LAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFN  66

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++    I  AV+      G +D LVN A +         T++    W+ V+ VN    +L
Sbjct  67   VTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRR---HPFTEFPEQEWNDVIAVNQTAVFL  123

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
            + QA   ++ + ++ K+INI S  +  G   +  Y ASKGA+  +TR M  EL   NI V
Sbjct  124  VSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQV  183

Query  189  NTLSPGLTLVEATE-YVPQERHDLYVTGRA-IQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            N ++PG    E T+  V  E    ++  R    R   PQ+L G A++L S  + FV G  
Sbjct  184  NGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHL  243

Query  247  IPVNGGFV  254
            + V+GG +
Sbjct  244  LFVDGGML  251


>Q8WNV7 Dehydrogenase/reductase SDR family member 4 [Sus scrofa]
Length=279

 Score = 127 bits (320),  Expect = 6e-39
 Identities = 80/246 (33%), Positives = 133/246 (54%), Gaps = 4/246 (2%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L  K  +VT +  G+GL  A+ +A+ GA V+++    E V+     LQ +GL V      
Sbjct  31   LENKVALVTASTDGIGLAIARRLAQDGAHVVVSSRKQENVDRTVATLQGEGLSVTGTVCH  90

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            + + E  +  V  AVN  GG+D LV+ AA+    G  ++     ++WD+++ VNVK T L
Sbjct  91   VGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFG--NIIDATEEVWDKILHVNVKATVL  148

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
            M +A VP +++     ++ ++S  A    P L  Y  SK A+L +T+++A EL   NI V
Sbjct  149  MTKAVVPEMEKRGGGSVLIVSSVGAYHPFPNLGPYNVSKTALLGLTKNLAVELAPRNIRV  208

Query  189  NTLSPGLTLVEATE--YVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            N L+PGL     ++  ++ + R +       I+R  +P+D  G   +L S+ AS++TG+ 
Sbjct  209  NCLAPGLIKTNFSQVLWMDKARKEYMKESLRIRRLGNPEDCAGIVSFLCSEDASYITGET  268

Query  247  IPVNGG  252
            + V GG
Sbjct  269  VVVGGG  274


>Q92EU6 NAD-dependent glycerol dehydrogenase [Listeria innocua 
serovar 6a (strain ATCC BAA-680 / CLIP 11262)]
Length=254

 Score = 126 bits (317),  Expect = 9e-39
 Identities = 83/247 (34%), Positives = 138/247 (56%), Gaps = 15/247 (6%)

Query  12   KKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLDLSQ  71
            K  +VTGAA G+G   A+  +E GA V++ DI  E V+  A Q+     +  A+ +D+++
Sbjct  15   KVAVVTGAASGIGKAMAELFSEKGAYVVLLDIK-EDVKDVAAQINPS--RTLALQVDITK  71

Query  72   PESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWLMVQ  131
             E+I+  V      +  +D L N A +A     +DL +   + WD+ M +N+KG++LM Q
Sbjct  72   KENIEKVVAEIKKVYPKIDILANSAGVALLEKAEDLPE---EYWDKTMELNLKGSFLMAQ  128

Query  132  ACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICVNTL  191
                 +  +   KI+N+AS  ++    K +AY ASK AI+SMT+ +A E   +NI VN +
Sbjct  129  IIGREMIATGGGKIVNMASQASVIALDKHVAYCASKAAIVSMTQVLAMEWAPYNINVNAI  188

Query  192  SPGLTLVEATE-----YVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            SP + L E  +      V ++   L   GR      +P+++   AL+L+SD AS +TG+N
Sbjct  189  SPTVILTELGKKAWAGQVGEDMKKLIPAGRF----GYPEEVAACALFLVSDAASLITGEN  244

Query  247  IPVNGGF  253
            + ++GG+
Sbjct  245  LIIDGGY  251


>A7IQH5 2-(S)-hydroxypropyl-CoM dehydrogenase 3 [Xanthobacter 
autotrophicus (strain ATCC BAA-1158 / Py2)]
Length=255

 Score = 126 bits (317),  Expect = 1e-38
 Identities = 86/254 (34%), Positives = 122/254 (48%), Gaps = 17/254 (7%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L  + I +TG   G+GL  A A    GA+V + D+   L E  A  L   G   +  G D
Sbjct  5    LKNEVIAITGGGAGIGLAIASAALREGAKVALIDLDQGLAERSAAMLSTGGAVAKGFGAD  64

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            +++   I  A+  A  T G L GLVN A +A   G   +   D   WDR+M VNV GT+L
Sbjct  65   VTKAADITAAITSAEQTIGSLTGLVNNAGIA---GFGSVHDADAAAWDRIMAVNVTGTFL  121

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
              +A +  + +     I+N  S   L G P + AY A+KGAI+++TR MA +     + V
Sbjct  122  ASKAALAGMLERHKGTIVNFGSVAGLVGIPTMAAYCAAKGAIVNLTRQMAADYSGRGVRV  181

Query  189  NTLSPG----------LTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDL  238
            N + PG          L   + +  V   R   Y  GR       P+D+    ++LLSD 
Sbjct  182  NAVCPGTVTSTGMGQQLLGSDTSPEVQARRLAKYPIGRF----GTPEDIAEAVIFLLSDQ  237

Query  239  ASFVTGQNIPVNGG  252
            A+FVTG    V+GG
Sbjct  238  AAFVTGAAFAVDGG  251


>Q937L4 Cyclopentanol dehydrogenase [Comamonas testosteroni]
Length=250

 Score = 125 bits (314),  Expect = 2e-38
 Identities = 82/254 (32%), Positives = 135/254 (53%), Gaps = 13/254 (5%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            ++ K ++VTG A G+GL     +A  GA V ++D+  EL      ++++QG +   + LD
Sbjct  4    VNDKVVLVTGGAMGMGLTHCTLLAREGATVYLSDMNEELGHQAVAEIRRQGGKAHFLHLD  63

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++       AV   +     LD LVN A + T    +D +  +   WDR+  +NV+  +L
Sbjct  64   VTNENHWTGAVDTILAESDRLDALVNNAGILTLKPVQDTSNEE---WDRIFEINVRSVFL  120

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
              +A +  ++++    I+N++S   L GAP   AY ASKGA+   T++ A +L  FNI V
Sbjct  121  GTRAVIEPMRKAHKGCIVNVSSIYGLVGAPGAAAYEASKGAVRLFTKACAVDLAPFNIRV  180

Query  189  NTLSPGLTLVEATEYV---PQERHDLY---VTGRAIQRQQHPQDLNGTALYLLSDLASFV  242
            N++ PG+     T+ +   PQ    L    + GRA Q    P +++   L+L+SD ASFV
Sbjct  181  NSVHPGVIATPMTQQILDAPQSARALLGPTLLGRAAQ----PMEVSQAVLFLVSDEASFV  236

Query  243  TGQNIPVNGGFVFN  256
             G  + V+GG+  N
Sbjct  237  HGSELVVDGGYTAN  250


>Q8GAV9 Cyclopentanol dehydrogenase [Comamonas sp. (strain NCIMB 
9872)]
Length=250

 Score = 125 bits (314),  Expect = 2e-38
 Identities = 82/254 (32%), Positives = 135/254 (53%), Gaps = 13/254 (5%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            ++ K ++VTG A G+GL     +A  GA V ++D+  EL      ++++QG +   + LD
Sbjct  4    VNDKVVLVTGGAMGMGLTHCTLLAREGATVYLSDMNEELGHQAVAEIRRQGGKAHFLHLD  63

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            ++       AV   +     LD LVN A + T    +D +  +   WDR+  +NV+  +L
Sbjct  64   VTNENHWTGAVDTILAESDRLDALVNNAGILTLKPVQDTSNEE---WDRIFEINVRSVFL  120

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
              +A +  ++++    I+N++S   L GAP   AY ASKGA+   T++ A +L  FNI V
Sbjct  121  GTRAVIEPMRKAHKGCIVNVSSIYGLVGAPGAAAYEASKGAVRLFTKACAVDLAPFNIRV  180

Query  189  NTLSPGLTLVEATEYV---PQERHDLY---VTGRAIQRQQHPQDLNGTALYLLSDLASFV  242
            N++ PG+     T+ +   PQ    L    + GRA Q    P +++   L+L+SD ASFV
Sbjct  181  NSVHPGVIATPMTQQILDAPQSARALLGPTLLGRAAQ----PMEVSQAVLFLVSDEASFV  236

Query  243  TGQNIPVNGGFVFN  256
             G  + V+GG+  N
Sbjct  237  HGSELVVDGGYTAN  250


>Q5P5I4 (S)-1-Phenylethanol dehydrogenase [Aromatoleum aromaticum 
(strain EbN1)]
Length=249

 Score = 124 bits (312),  Expect = 5e-38
 Identities = 84/248 (34%), Positives = 130/248 (52%), Gaps = 7/248 (3%)

Query  9    LHGKKIIVTGAARGLGLGFAQAIAEAGAQVIMADILIELVEGEAKQLQQQGLQVQAVGLD  68
            L  K  ++TG A G+G   A+  A  GA + +AD L+   E EA  ++  G +V  V  D
Sbjct  5    LKDKLAVITGGANGIGRAIAERFAVEGADIAIAD-LVPAPEAEAA-IRNLGRRVLTVKCD  62

Query  69   LSQPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWL  128
            +SQP  ++   +  ++T+G  D LVN A +   +   +LT    + W +   +NV   +L
Sbjct  63   VSQPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTF---EQWKKTFEINVDSGFL  119

Query  129  MVQACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICV  188
            M +A VP +K++   +IIN+ S T          Y+++K A +  TR++A +LG+  I V
Sbjct  120  MAKAFVPGMKRNGWGRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGKDGITV  179

Query  189  NTLSPGLTLVEATEYVPQERHDLYVTG--RAIQRQQHPQDLNGTALYLLSDLASFVTGQN  246
            N ++P L     TE          +    +AI R Q P DL G A +L SD ASF+TGQ 
Sbjct  180  NAIAPSLVRTATTEASALSAMFDVLPNMLQAIPRLQVPLDLTGAAAFLASDDASFITGQT  239

Query  247  IPVNGGFV  254
            + V+GG V
Sbjct  240  LAVDGGMV  247


>P99093 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Staphylococcus 
aureus (strain N315)]
Length=246

 Score = 122 bits (307),  Expect = 2e-37
 Identities = 74/242 (31%), Positives = 125/242 (52%), Gaps = 4/242 (2%)

Query  12   KKIIVTGAARGLGLGFAQAIAEAGAQVIMADI-LIELVEGEAKQLQQQGLQVQAVGLDLS  70
            K  +VTGA+RG+G   A  +AE G  V +      E  E   ++++ +G+   A+  +++
Sbjct  5    KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVA  64

Query  71   QPESIQTAVQFAVNTWGGLDGLVNCAALATGVGGKDLTQYDPDLWDRVMTVNVKGTWLMV  130
              + ++  ++  V+ +G LD LVN A +        L +     WD V+  N+KG +  +
Sbjct  65   DADEVKAMIKEVVSQFGSLDVLVNNAGITRD---NLLMRMKEQEWDDVIDTNLKGVFNCI  121

Query  131  QACVPYLKQSQSAKIINIASDTALWGAPKLMAYVASKGAILSMTRSMARELGEFNICVNT  190
            Q   P + + +S  IIN++S     G P    YVA+K  ++ +T+S AREL    I VN 
Sbjct  122  QKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNA  181

Query  191  LSPGLTLVEATEYVPQERHDLYVTGRAIQRQQHPQDLNGTALYLLSDLASFVTGQNIPVN  250
            ++PG  + + T+ +  E  +  +T   + R     D+  T  +L SD A ++TGQ I VN
Sbjct  182  VAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVN  241

Query  251  GG  252
            GG
Sbjct  242  GG  243



Lambda      K        H        a         alpha
   0.321    0.136    0.399    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 887784


  Database: 133c47877461e6978cb74f3d87910052.SwissProt.fasta
    Posted date:  May 20, 2024  3:03 AM
  Number of letters in database: 5,048
  Number of sequences in database:  20



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40