BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 7288313078715d3d9fb0ae9d134dc0f5.SwissProt.fasta
           13 sequences; 4,688 total letters



Query= ACIAD1021

Length=372
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

O34788 (R,R)-butanediol dehydrogenase [Bacillus subtilis (strain ...  279     2e-95
P39714 (R,R)-butanediol dehydrogenase [Saccharomyces cerevisiae (...  222     8e-73
P39713 Probable diacetyl reductase [(R)-acetoin forming] 2 [Sacch...  192     5e-61
Q15SS1 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase [Pseudoalt...  174     9e-55
Q06004 Sorbitol dehydrogenase [Bacillus subtilis (strain 168)]        172     9e-54
P0DMQ6 Sorbitol dehydrogenase [Gallus gallus]                         157     3e-48
Q4R639 Sorbitol dehydrogenase [Macaca fascicularis]                   155     3e-47
Q58D31 Sorbitol dehydrogenase [Bos taurus]                            153     1e-46
Q00796 Sorbitol dehydrogenase [Homo sapiens]                          153     1e-46
Q07786 Sorbitol dehydrogenase 2 [Saccharomyces cerevisiae (strain...  152     3e-46
P35497 Sorbitol dehydrogenase 1 [Saccharomyces cerevisiae (strain...  152     4e-46
Q07993 D-xylulose reductase [Saccharomyces cerevisiae (strain ATC...  151     8e-46
P07846 Sorbitol dehydrogenase [Ovis aries]                            150     2e-45


>O34788 (R,R)-butanediol dehydrogenase [Bacillus subtilis (strain 
168)]
Length=346

 Score = 279 bits (713),  Expect = 2e-95
 Identities = 159/354 (45%), Positives = 222/354 (63%), Gaps = 11/354 (3%)

Query  20   MKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPI  79
            MKAAR++++ DIRIE I EP+   G V I+V WCGICG+DLHE++ GPIFIP    PHP+
Sbjct  1    MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIP-VDKPHPL  59

Query  80   SGESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNF  139
            + E+AP+TMGHEFSG V  VGEGV++ +VG  VVVEP         G    Y+L + M F
Sbjct  60   TNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATH----GHQGAYNLDEQMGF  115

Query  140  IGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVG  199
            +GL G GGG SE ++V    +  + + +  +Q AL+EP +V  +A   S  KAGD A V 
Sbjct  116  LGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYAVRSSKLKAGDKAAVF  175

Query  200  GAGPIGLLLSAILKAKGLT-VIITELSSKRKEKAKESGVADYILDPTQV-DVIAEVMKIT  257
            G GPIGLL+   LKA G T +   ELS +R++KA+E G    I+DP++  DV+AE+ + T
Sbjct  176  GCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGA--IIVDPSKTDDVVAEIAERT  233

Query  258  QDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIA  317
               G D+AFE + V  VL   + ST   G  VIVSIW   A ++ + +V+KE  ++G I 
Sbjct  234  -GGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIG  292

Query  318  YVNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP  371
            Y +     + L+++G  +    +T++I LDDLI +GF  LI   +S VKI+V P
Sbjct  293  YRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALI-KEKSQVKILVRP  345


>P39714 (R,R)-butanediol dehydrogenase [Saccharomyces cerevisiae 
(strain ATCC 204508 / S288c)]
Length=382

 Score = 222 bits (566),  Expect = 8e-73
 Identities = 132/379 (35%), Positives = 211/379 (56%), Gaps = 31/379 (8%)

Query  20   MKAARFYDRGDIRI-EDIPEPEV-TAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPH  77
            M+A  ++ +GDI    DIP PE+ T   V I V+WCGICG+DLHE+++GPIF+P  G  H
Sbjct  1    MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECH  60

Query  78   PISGESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSK--  135
             +S  + P+ MGHE SG+V  VG  V  ++VG HVVV+      D+   P   ++ SK  
Sbjct  61   KLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPC  120

Query  136  ------------NMNFIGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHH  183
                        +  F+GLG   GG +E++ V +  + P+ + IPLD AAL+EPLSV  H
Sbjct  121  DACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWH  180

Query  184  AYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLT-VIITELSSKRKEKAKESGVADYIL  242
            A   SG K G  ALV GAGPIGL    +LK  G + ++++E++ +R E AK+ GV   + 
Sbjct  181  AVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVE--VF  238

Query  243  DPTQ-----VDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWS-H  296
            +P++     ++++  + K     G D +++CS +    +T + +    G    +++W   
Sbjct  239  NPSKHGHKSIEILRGLTK--SHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPK  296

Query  297  PATVNVHSVVMKELDIRGTIAY-VNDHQETIKLVEQGKI---NLAPFITQRIKLDDLISQ  352
            P       V ++E  + G+I Y V D +E ++ +  G I   +    IT + +++D   +
Sbjct  297  PVPFQPMDVTLQEKVMTGSIGYVVEDFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEK  356

Query  353  GFETLIHNNESAVKIIVHP  371
            GF+ L+ + ES VKI++ P
Sbjct  357  GFQELMDHKESNVKILLTP  375


>P39713 Probable diacetyl reductase [(R)-acetoin forming] 2 [Saccharomyces 
cerevisiae (strain ATCC 204508 / S288c)]
Length=417

 Score = 192 bits (489),  Expect = 5e-61
 Identities = 124/380 (33%), Positives = 194/380 (51%), Gaps = 32/380 (8%)

Query  20   MKAARFYDRGDIRIED-IPEPEVTA-GTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPH  77
            M+A  ++ +G+IR  + + EP + A   + I + WCGICGTDLHE+ +GPIF P  GH H
Sbjct  1    MRALAYFGKGNIRFTNHLKEPHIVAPDELVIDIEWCGICGTDLHEYTDGPIFFPEDGHTH  60

Query  78   PISGESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADD---VPTGPGEN----  130
             IS    P  MGHE +G V  VG GV +++VG  VVVEP     D    P  P  +    
Sbjct  61   EISHNPLPQAMGHEMAGTVLEVGPGVKNLKVGDKVVVEPTGTCRDRYRWPLSPNVDKEWC  120

Query  131  -------YHLSKNMNFIGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHH  183
                   Y++   +   G G + GG +E++ +     + + + +PLD AALI+PL+V  H
Sbjct  121  AACKKGYYNICSYLGLCGAGVQSGGFAERVVMNESHCYKVPDFVPLDVAALIQPLAVCWH  180

Query  184  AYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGL-TVIITELSSKRKEKAKESGVADYIL  242
            A      KAG  AL+ GAGPIGL     L A G   ++++E +  R+E A++ G   Y  
Sbjct  181  AIRVCEFKAGSTALIIGAGPIGLGTILALNAAGCKDIVVSEPAKVRRELAEKMGARVY--  238

Query  243  DPT------QVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWS-  295
            DPT       +D +  +       G D  F+CS +   L+  +      G  V +++W  
Sbjct  239  DPTAHAAKESIDYLRSI--ADGGDGFDYTFDCSGLEVTLNAAIQCLTFRGTAVNLAMWGH  296

Query  296  HPATVNVHSVVMKELDIRGTIAYV-NDHQETIKLVEQGKINL---APFITQRIKLDDLIS  351
            H    +   + + E    G++ Y  +D +  I+ +E+G+I++      IT R+ ++D + 
Sbjct  297  HKIQFSPMDITLHERKYTGSMCYTHHDFEAVIEALEEGRIDIDRARHMITGRVNIEDGLD  356

Query  352  QGFETLIHNNESAVKIIVHP  371
                 LI+  ES +KII+ P
Sbjct  357  GAIMKLINEKESTIKIILTP  376


>Q15SS1 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase [Pseudoalteromonas 
atlantica (strain T6c / ATCC BAA-1087)]
Length=341

 Score = 174 bits (441),  Expect = 9e-55
 Identities = 115/331 (35%), Positives = 171/331 (52%), Gaps = 28/331 (8%)

Query  43   AGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGE--SAPITMGHEFSGVVYAVG  100
            AG V + V + GICGTD+H +             H +  +  S P T+GHE SGVV  +G
Sbjct  24   AGEVRLDVGYVGICGTDMHIY-------------HGVMDQRVSIPQTIGHEISGVVAQIG  70

Query  101  EGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWV  160
            EGV+   VG+ VVV P     + PT      H+ +N+ F+G+    G       V+ R +
Sbjct  71   EGVEGFTVGEKVVVRPLDWCGECPTCEAGLTHICQNLKFMGID-TPGAFQSSWTVKARTL  129

Query  161  HPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVI  220
            H +   + L Q AL+EPLSV  H   RS  KAG+ A++ G GPIG L++A+ K+ G  V+
Sbjct  130  HKLPAGVDLKQGALVEPLSVACHDVRRSRLKAGEKAVILGGGPIGQLVAAVAKSVGAEVL  189

Query  221  ITELSSKRKEKAKESGVADYILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVA  280
            ++E +  R+E A E GV    ++P   D+ A V + T  KGAD+ FE S V   + ++  
Sbjct  190  VSEPNDSRREFADELGVKS--VNPMDTDLAAYVDQWTGTKGADVVFEVSGVLPAIQSMTQ  247

Query  281  STKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAY-VNDHQETIKLVEQGKINLAPF  339
                 G IV+V+I S    +++     KEL++ G   Y   D    I+L+  G+I+L PF
Sbjct  248  IAGRRGRIVMVAIHSTAPPIDLFQFFWKELELLGARVYEAADFDWAIELIASGQIDLKPF  307

Query  340  ITQRIKLDDLIS---------QGFETLIHNN  361
            I+    L D+ S         QG + L+  N
Sbjct  308  ISSVSPLADIGSAFANMDGNPQGMKALVECN  338


>Q06004 Sorbitol dehydrogenase [Bacillus subtilis (strain 168)]
Length=353

 Score = 172 bits (435),  Expect = 9e-54
 Identities = 110/357 (31%), Positives = 181/357 (51%), Gaps = 19/357 (5%)

Query  20   MKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPI  79
            MKAA  ++  +I+IE +P P++    V I+V   GICG+DLH +  G I           
Sbjct  9    MKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGICGSDLHYYTNGRI-----------  57

Query  80   SGE---SAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKN  136
             G      P  +GHE +G + AVG  VD  +VG  V VEP +            Y+L  +
Sbjct  58   -GNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGRCEACKEGRYNLCPD  116

Query  137  MNFIGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVA  196
            + F+      G   + I +++ +V  I +++  ++AALIEP SVG HA  R+  + G   
Sbjct  117  VQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSVGIHAAARTKLQPGSTI  176

Query  197  LVGGAGPIGLLLSAILKAKGL-TVIITELSSKRKEKAKESGVADYILDPTQVDVIAEVMK  255
             + G GP+GL+  A  KA G  T+I+T+L   R E AK+ G A +I++  + D + E+  
Sbjct  177  AIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMG-ATHIINIREQDALEEIKT  235

Query  256  ITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWS-HPATVNVHSVVMKELDIRG  314
            IT D+G D+A+E +     L + +AS +  G + IV + S +   +NV  +   E+DI G
Sbjct  236  ITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQNEIPLNVPFIADNEIDIYG  295

Query  315  TIAYVNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP  371
               Y N + + I+ +  G ++    +T +  L+       E  +      +K++V+P
Sbjct  296  IFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQ-TQDAMERALQFKNECLKVMVYP  351


>P0DMQ6 Sorbitol dehydrogenase [Gallus gallus]
Length=355

 Score = 157 bits (398),  Expect = 3e-48
 Identities = 106/334 (32%), Positives = 167/334 (50%), Gaps = 20/334 (6%)

Query  29   GDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPI--FIPPCGHPHPISGESAPI  86
            GD+R+E+ P PE     V +++   GICG+D+H +  G I  F+              P+
Sbjct  16   GDLRLENRPIPEPGPNEVLLRMHSVGICGSDVHYWQHGRIGDFVV-----------KDPM  64

Query  87   TMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRG  146
             +GHE SG V  VG GV  ++ G  V +EP +  +         Y+LS  + F       
Sbjct  65   VLGHEASGTVIKVGAGVTHLKPGDRVAIEPGVPRETDEFCKTGRYNLSPTIFFCATPPDD  124

Query  147  GGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGL  206
            G L         + + + +++  ++ ALIEPLSVG HA  R+G   G    V G+GPIGL
Sbjct  125  GNLCRYYKHSASYCYKLPDSVTFEEGALIEPLSVGIHACKRAGVTLGSRVFVSGSGPIGL  184

Query  207  LLSAILKAKG-LTVIITELSSKRKEKAKESGVADY---ILDPTQVDVIAEVMKITQDKGA  262
            +   I K  G   V++T+LS+ R + AKE G AD+   I + T  +V A+V  +      
Sbjct  185  VNVIIAKMMGAAAVVVTDLSASRLQTAKELG-ADFTIQIKNETPQEVAAKVESLLGCM-P  242

Query  263  DIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVNDH  322
            +I  EC+ V   +   + +T+  G +V+V +     TV + +  ++E+DIRG   Y N  
Sbjct  243  EITVECTGVQACIQASIYATRSGGTLVLVGLGPEMVTVPIVNAAVREVDIRGIFRYCNTW  302

Query  323  QETIKLVEQGKINLAPFITQRIKLDDLISQGFET  356
               I L+   +IN+ P +T R  L+  + + FET
Sbjct  303  PVAISLLASKRINIKPLVTHRFPLEKAL-EAFET  335


>Q4R639 Sorbitol dehydrogenase [Macaca fascicularis]
Length=357

 Score = 155 bits (391),  Expect = 3e-47
 Identities = 103/333 (31%), Positives = 165/333 (50%), Gaps = 18/333 (5%)

Query  29   GDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPI--FIPPCGHPHPISGESAPI  86
            GD+R+E+ P PE     V +++   GICG+D+H + EG I  FI              P+
Sbjct  18   GDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEEGRIGNFIV-----------KKPM  66

Query  87   TMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRG  146
             +GHE SG V  VG  V  ++ G  V +EP +  ++        Y+LS ++ F       
Sbjct  67   VLGHEASGTVEKVGSLVKHLKPGDRVAIEPGVPRENDEFCKSGRYNLSPSIFFCATPPDD  126

Query  147  GGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGL  206
            G L         + + + +N+  ++ ALIEPLSVG HA  R G   G   LV GAGPIG+
Sbjct  127  GNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHRVLVCGAGPIGV  186

Query  207  LLSAILKAKGLT-VIITELSSKRKEKAKESGVADYILDPTQVDVIAEVMKITQDKGA--D  263
            +   + KA G   V++T+LS+ R  KAKE G AD +L  ++        K+    G   +
Sbjct  187  VSLLVAKAMGAAQVVVTDLSAPRLSKAKEIG-ADLVLQISKESPQEIAGKVEGLLGCKPE  245

Query  264  IAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVNDHQ  323
            +  EC+     +   + +T+  G +V+V + S   T+ +    ++E+DI+G   Y N   
Sbjct  246  VTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTIPLLHAAVREVDIKGVFRYCNTWP  305

Query  324  ETIKLVEQGKINLAPFITQRIKLDDLISQGFET  356
              I ++    +N+ P +T R  L+  + + FET
Sbjct  306  VAISMLASKSVNIKPLVTHRFPLEKAL-EAFET  337


>Q58D31 Sorbitol dehydrogenase [Bos taurus]
Length=356

 Score = 153 bits (387),  Expect = 1e-46
 Identities = 105/333 (32%), Positives = 163/333 (49%), Gaps = 18/333 (5%)

Query  29   GDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPI--FIPPCGHPHPISGESAPI  86
            GD+R+E+ P PE     V +++   GICG+D+H +  G I  F+              P+
Sbjct  17   GDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVV-----------KKPM  65

Query  87   TMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRG  146
             +GHE SG V  VG  V  +Q G  V +EP    +         Y+LS  + F       
Sbjct  66   VLGHEASGTVVKVGSLVRHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPTIFFCATPPDD  125

Query  147  GGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGL  206
            G L         + + + +N+  ++ ALIEPLSVG HA  R+G   G+  LV GAGPIGL
Sbjct  126  GNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGL  185

Query  207  LLSAILKAKGLT-VIITELSSKRKEKAKESGVADYILDPT--QVDVIAEVMKITQDKGAD  263
            +     KA G   V++T+LS+ R  KAKE G AD+IL  +      IA+ ++       +
Sbjct  186  VSLLAAKAMGAAQVVVTDLSASRLSKAKEVG-ADFILQISNESPQEIAKKVEGLLGSKPE  244

Query  264  IAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVNDHQ  323
            +  EC+ V   +   + +T   G +V+V + S   +V +     +E+DI+G   Y N   
Sbjct  245  VTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNTWP  304

Query  324  ETIKLVEQGKINLAPFITQRIKLDDLISQGFET  356
              I ++    +N+ P +T R  L+  + + FET
Sbjct  305  MAISMLASKSVNVKPLVTHRFPLEKAL-EAFET  336


>Q00796 Sorbitol dehydrogenase [Homo sapiens]
Length=357

 Score = 153 bits (387),  Expect = 1e-46
 Identities = 103/333 (31%), Positives = 163/333 (49%), Gaps = 18/333 (5%)

Query  29   GDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPI--FIPPCGHPHPISGESAPI  86
            GD+R+E+ P PE     V +++   GICG+D+H +  G I  FI              P+
Sbjct  18   GDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIV-----------KKPM  66

Query  87   TMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRG  146
             +GHE SG V  VG  V  ++ G  V +EP    ++        Y+LS ++ F       
Sbjct  67   VLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDD  126

Query  147  GGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGL  206
            G L         + + + +N+  ++ ALIEPLSVG HA  R G   G   LV GAGPIG+
Sbjct  127  GNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGM  186

Query  207  LLSAILKAKGLT-VIITELSSKRKEKAKESGVADYILDPTQVDVIAEVMKITQDKGA--D  263
            +   + KA G   V++T+LS+ R  KAKE G AD +L  ++        K+    G   +
Sbjct  187  VTLLVAKAMGAAQVVVTDLSATRLSKAKEIG-ADLVLQISKESPQEIARKVEGQLGCKPE  245

Query  264  IAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVNDHQ  323
            +  EC+     +   + +T+  G +V+V + S   TV +    ++E+DI+G   Y N   
Sbjct  246  VTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWP  305

Query  324  ETIKLVEQGKINLAPFITQRIKLDDLISQGFET  356
              I ++    +N+ P +T R  L+  + + FET
Sbjct  306  VAISMLASKSVNVKPLVTHRFPLEKAL-EAFET  337


>Q07786 Sorbitol dehydrogenase 2 [Saccharomyces cerevisiae (strain 
ATCC 204508 / S288c)]
Length=357

 Score = 152 bits (384),  Expect = 3e-46
 Identities = 108/358 (30%), Positives = 171/358 (48%), Gaps = 31/358 (9%)

Query  29   GDIRIEDIPEPEVT-AGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGE---SA  84
            GDI IE  P P +     V + +   GICG+D+H +  G I            G+    A
Sbjct  15   GDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGI------------GKYILKA  62

Query  85   PITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYI---VADDVPTGPGENYHLSKNMNFIG  141
            P+ +GHE SG V  VG+ V  ++VG  V +EP +    +D+   G   +Y+L  +M F  
Sbjct  63   PMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEG---SYNLCPHMAFAA  119

Query  142  LGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGA  201
                 G L +       ++  + E +  ++ A +EPLSVG H+   +G + G   +V GA
Sbjct  120  TPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGA  179

Query  202  GPIGLLLSAILKAKGLT-VIITELSSKRKEKAKESGV------ADYILDPTQVDVIAEVM  254
            GP+GLL  A+ +A G T VI  ++   + ++AK+ G       + +  D  Q D+   V 
Sbjct  180  GPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQ-DLADGVQ  238

Query  255  KITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRG  314
            K+     AD+ FECS  +  +D  V +TK  G +V V +  +     +  V  KE+ + G
Sbjct  239  KLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIG  298

Query  315  TIAY-VNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP  371
               Y   D+++ + LV  GK+N+ P IT + K +D        + H  E    II  P
Sbjct  299  CFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGP  356


>P35497 Sorbitol dehydrogenase 1 [Saccharomyces cerevisiae (strain 
ATCC 204508 / S288c)]
Length=357

 Score = 152 bits (383),  Expect = 4e-46
 Identities = 108/358 (30%), Positives = 170/358 (47%), Gaps = 31/358 (9%)

Query  29   GDIRIEDIPEPEVT-AGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGE---SA  84
            GDI IE  P P +     V + +   GICG+D+H +  G I            G+    A
Sbjct  15   GDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGI------------GKYILKA  62

Query  85   PITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYI---VADDVPTGPGENYHLSKNMNFIG  141
            P+ +GHE SG V  VG+ V  ++VG  V +EP +    +D+   G    Y+L  +M F  
Sbjct  63   PMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEG---RYNLCPHMAFAA  119

Query  142  LGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGA  201
                 G L +       ++  + E +  ++ A +EPLSVG H+   +G + G   +V GA
Sbjct  120  TPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGA  179

Query  202  GPIGLLLSAILKAKGLT-VIITELSSKRKEKAKESGV------ADYILDPTQVDVIAEVM  254
            GP+GLL  A+ +A G T VI  ++   + ++AK+ G       + +  D  Q D+   V 
Sbjct  180  GPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQ-DLADGVQ  238

Query  255  KITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRG  314
            K+     AD+ FECS  +  +D  V +TK  G +V V +  +     +  V  KE+ + G
Sbjct  239  KLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIG  298

Query  315  TIAY-VNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP  371
               Y   D+++ + LV  GK+N+ P IT + K +D        + H  E    II  P
Sbjct  299  CFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGP  356


>Q07993 D-xylulose reductase [Saccharomyces cerevisiae (strain 
ATCC 204508 / S288c)]
Length=356

 Score = 151 bits (381),  Expect = 8e-46
 Identities = 106/348 (30%), Positives = 169/348 (49%), Gaps = 18/348 (5%)

Query  29   GDIRIEDIPEPEVT-AGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPIT  87
            G I + ++  P+++    V IQ+   GICG+D+H +  G I               +P+ 
Sbjct  16   GKITLTNVSIPKISDPNEVIIQIKATGICGSDIHYYTHGRIANYVV---------ESPMV  66

Query  88   MGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRGG  147
            +GHE SG+V  +GE V  ++VG  V +EP I     P      Y+L  N+ F       G
Sbjct  67   LGHESSGIVALIGENVKTLKVGDRVALEPGIPDRFSPEMKEGRYNLDPNLKFAATPPFDG  126

Query  148  GLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLL  207
             L++     + +V+ + +++  ++ ALIEPLSV  HA   +  K G   +V GAGPIGLL
Sbjct  127  TLTKYYKTMKDFVYKLPDDVSFEEGALIEPLSVAIHANKLAKIKFGARCVVFGAGPIGLL  186

Query  208  LSAILKAKGLT-VIITELSSKRKEKAKESGVADYILD----PTQVDVIAEVMKITQDKGA  262
               +    G   V+  +L   + E A++ G A +I++    P  V V + + K    KGA
Sbjct  187  AGKVASVFGAADVVFVDLLENKLETARQFG-ATHIVNSGDLPHGVTVDSVIKKAIGKKGA  245

Query  263  DIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYV-ND  321
            D+ FECS     +   +   K  G IV V +        +  +  KEL  +G   Y   D
Sbjct  246  DVVFECSGAEPCVRAGIEVCKAGGTIVQVGMGQEEIQFPISIIPTKELTFQGCFRYCQGD  305

Query  322  HQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIV  369
            + ++I+LV   K++L PFIT R    D + + FE   H+  + +K I+
Sbjct  306  YSDSIELVSSRKLSLKPFITHRYSFKDAV-EAFEETSHHPLNNIKTII  352


>P07846 Sorbitol dehydrogenase [Ovis aries]
Length=354

 Score = 150 bits (378),  Expect = 2e-45
 Identities = 104/333 (31%), Positives = 165/333 (50%), Gaps = 19/333 (6%)

Query  29   GDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPI--FIPPCGHPHPISGESAPI  86
            GD+R+E+ P PE     V +++   GICG+D+H + +G I  F+              P+
Sbjct  16   GDLRLENYPIPEPGPNEVLLKMHSVGICGSDVH-YWQGRIGDFVV-----------KKPM  63

Query  87   TMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRG  146
             +GHE SG V  VG  V  +Q G  V ++P              Y+LS  + F       
Sbjct  64   VLGHEASGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFCKIGRYNLSPTIFFCATPPDD  123

Query  147  GGLSEKIAVQRRWVHPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGL  206
            G L         + + + +N+  ++ ALIEPLSVG HA  R+G   G+  LV GAGPIGL
Sbjct  124  GNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGL  183

Query  207  LLSAILKAKGLT-VIITELSSKRKEKAKESGVADYILDPT--QVDVIAEVMKITQDKGAD  263
            +     KA G   V++T+LS+ R  KAKE G AD+IL+ +    + IA+ ++       +
Sbjct  184  VNLLAAKAMGAAQVVVTDLSASRLSKAKEVG-ADFILEISNESPEEIAKKVEGLLGSKPE  242

Query  264  IAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVNDHQ  323
            +  EC+ V   +   + +T   G +V+V + S   +V +     +E+DI+G   Y N   
Sbjct  243  VTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNTWP  302

Query  324  ETIKLVEQGKINLAPFITQRIKLDDLISQGFET  356
              I ++    +N+ P +T R  L+  + + FET
Sbjct  303  MAISMLASKSVNVKPLVTHRFPLEKAL-EAFET  334



Lambda      K        H        a         alpha
   0.320    0.139    0.412    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1325025


  Database: 7288313078715d3d9fb0ae9d134dc0f5.SwissProt.fasta
    Posted date:  May 20, 2024  3:36 AM
  Number of letters in database: 4,688
  Number of sequences in database:  13



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40