BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: b8dbf01f93a658702d42bec63a6f4fb9.SwissProt.fasta
18 sequences; 8,976 total letters
Query= ACIAD1084
Length=533
Score E
Sequences producing significant alignments: (Bits) Value
Q9I0K4 Isocitrate lyase [Pseudomonas aeruginosa (strain ATCC 1569... 771 0.0
O50078 Isocitrate lyase [Hyphomicrobium methylovorum] 589 0.0
P51066 Isocitrate lyase [Salmonella typhimurium (strain LT2 / SGS... 141 5e-40
Q8RQN6 Isocitrate lyase [Corynebacterium efficiens (strain DSM 44... 141 6e-40
P42449 Isocitrate lyase [Corynebacterium glutamicum (strain ATCC ... 140 2e-39
P0A9G7 Isocitrate lyase [Escherichia coli O6:H1 (strain CFT073 / ... 137 1e-38
P0A9G6 Isocitrate lyase [Escherichia coli (strain K12)] 137 1e-38
Q6BZP5 2-methylisocitrate lyase, mitochondrial [Yarrowia lipolyti... 138 3e-38
Q10663 Isocitrate lyase / Malate synthase [Caenorhabditis elegans] 140 4e-38
P41554 Isocitrate lyase [Rhodococcus fascians] 135 9e-38
Q9K9H0 Isocitrate lyase [Halalkalibacterium halodurans (strain AT... 134 2e-37
P9WKK7 Isocitrate lyase [Mycobacterium tuberculosis (strain ATCC ... 127 6e-35
P9WKK6 Isocitrate lyase 1 [Mycobacterium tuberculosis (strain CDC... 127 6e-35
H8EVV4 Isocitrate lyase 1 [Mycobacterium tuberculosis (strain ATC... 127 6e-35
P0A5H4 Isocitrate lyase 1 [Mycobacterium bovis (strain ATCC BAA-9... 127 6e-35
Q8NJ72 Isocitrate lyase [Kluyveromyces lactis (strain ATCC 8585 /... 110 1e-28
P28240 Isocitrate lyase [Saccharomyces cerevisiae (strain ATCC 20... 105 5e-27
P41555 Isocitrate lyase [Yarrowia lipolytica (strain CLIB 122 / E... 84.0 3e-20
>Q9I0K4 Isocitrate lyase [Pseudomonas aeruginosa (strain ATCC
15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C
/ PRS 101 / PAO1)]
Length=531
Score = 771 bits (1992), Expect = 0.0
Identities = 388/528 (73%), Positives = 437/528 (83%), Gaps = 1/528 (0%)
Query 3 YQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDAD 62
YQ+ ++ V A+K K G +W AI PE AARM +QNRF TGLDIAKYTAAIMRKDMAEYDAD
Sbjct 4 YQNEIKAVAALKEKNGSSWSAINPEYAARMRIQNRFKTGLDIAKYTAAIMRKDMAEYDAD 63
Query 63 NSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMHEK 122
+S YTQSLGCWHGFI QQK+I+ KK+ TTNKRY+YLSGWMVAALRS+FGPLPDQSMHEK
Sbjct 64 SSVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSDFGPLPDQSMHEK 123
Query 123 TAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIA 182
TAV LI E+YTFLRQADA+EL+ LF L A AAGD AK ++ +QIDNFETHVVPIIA
Sbjct 124 TAVSGLIEELYTFLRQADARELDLLFTGLDAARAAGDKAKEAELLAQIDNFETHVVPIIA 183
Query 183 DIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAV 242
DIDAGFGN EATYLL K+MIEAGAC IQIENQVSD KQCGHQ GKVTVPH DFLAKINAV
Sbjct 184 DIDAGFGNAEATYLLAKKMIEAGACCIQIENQVSDEKQCGHQDGKVTVPHIDFLAKINAV 243
Query 243 RYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDE 302
RYAFLELGVD+GVIVARTDS GA LT++I V+ E GDL Y S+LD +EI ++ +
Sbjct 244 RYAFLELGVDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDLYNSFLDCEEISESELGNGD 303
Query 303 ILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAG 362
++IKR+GKL RP RLAS L+QFR+GT DR VLDC+TSLQNGAD++WIET P V I
Sbjct 304 VVIKREGKLLRPKRLASNLFQFRKGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKA 363
Query 363 FVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTE 422
V+ I++ +PNAKLVYNNSPSFNWTLNFRQQ +D + AEGKDVSAYDR KLMS EYD+TE
Sbjct 364 MVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAFVAEGKDVSAYDRNKLMSVEYDDTE 423
Query 423 LAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQ 482
LA ADEKIRTFQ D + AG+FHHLITLPTYHTAALST LAKGYF +EGMLAYV GVQ
Sbjct 424 LAKVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDNLAKGYFADEGMLAYVKGVQ 483
Query 483 RKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQF 530
R+E+R GIACVKHQ MAGSDIGD+HKE FAGE ALKA NTMNQF
Sbjct 484 RQELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKA-SGKDNTMNQF 530
>O50078 Isocitrate lyase [Hyphomicrobium methylovorum]
Length=540
Score = 589 bits (1518), Expect = 0.0
Identities = 309/520 (59%), Positives = 381/520 (73%), Gaps = 6/520 (1%)
Query 17 LGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGF 76
+G T + +D ++ +Q+ + + LD+A+ A++MR DMA YD D +TQSLGCW GF
Sbjct 20 VGLTKGGVSIDDIVQLRLQSPYESHLDVARAMASVMRADMAAYDRDTGKFTQSLGCWSGF 79
Query 77 IAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMHEKTAVPKLIAEIYTFL 136
AQQ + A K+ GTT Y+YLSGWMVA LR+ +G LPDQSMHEKT+V LI EIY L
Sbjct 80 HAQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRWGHLPDQSMHEKTSVVDLIEEIYVSL 139
Query 137 RQADAKELNDLFRALQKAEAAGDSAKV-KDIESQIDNFETHVVPIIADIDAGFGNEEATY 195
RQAD LNDLF L+ A A G + K ++I S+ID FE+HVVPIIADIDAGFGNE ATY
Sbjct 140 RQADEVALNDLFNELKDARAKGATNKACEEIISRIDGFESHVVPIIADIDAGFGNEHATY 199
Query 196 LLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGV 255
LL K+MI+AGAC +QIENQVSDAKQCGHQ GKVTVP EDF+ K+ A R AF ELGVD+GV
Sbjct 200 LLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIEKLRACRLAFEELGVDDGV 259
Query 256 IVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEI-DIADAQEDEILIKRDGKLHRP 314
IVARTDS GA LTQKIPVS++ GD AS YI +L T+ I D E E+ I + G RP
Sbjct 260 IVARTDSLGASLTQKIPVSQQAGDFASSYIKWLKTEPITDANPLSEGELAIWQSGNFARP 319
Query 315 TRLASGLYQFREGTQHDRVVLDCVTSLQNG-ADMIWIETPTPDVAGIAGFVNDIKKQVPN 373
R+ +GL+ FREGT RV+ DC+ SL++G AD+IWIET TP+V IA V +I+KQVP+
Sbjct 320 IRMPNGLFSFREGTGRARVIEDCIASLKDGDADLIWIETDTPNVDEIASMVAEIRKQVPD 379
Query 374 AKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSA--YDRAKLMSAEYDNTELAADADEKI 431
AKLVYNNSPSFNWTLN R+Q +W +EGK A D LMSA+YD +EL +AD+++
Sbjct 380 AKLVYNNSPSFNWTLNLRKQVRAQWISEGKIAEADYPDGTALMSAQYDTSELGREADDRL 439
Query 432 RTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEIRGGIA 491
R FQ D + AGVFH+LITLPT+H A ST EL+ GYFGE+ MLAYVA VQR+EIR I+
Sbjct 440 RQFQVDISARAGVFHNLITLPTFHLTAKSTDELSHGYFGEDRMLAYVATVQREEIRRSIS 499
Query 492 CVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFA 531
V+HQ GSD+GD KE+ +G++ALKAG A NTMNQFA
Sbjct 500 AVRHQHEVGSDLGDTFKEMVSGDRALKAGGA-HNTMNQFA 538
>P51066 Isocitrate lyase [Salmonella typhimurium (strain LT2 /
SGSC1412 / ATCC 700720)]
Length=434
Score = 141 bits (356), Expect = 5e-40
Identities = 136/499 (27%), Positives = 203/499 (41%), Gaps = 107/499 (21%)
Query 21 WDAI-RPEDAARMI-VQNRFHTGLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIA 78
W+ I RP A ++ ++ + +A+ AA M + + + Y SLG G A
Sbjct 20 WEGITRPYSAEEVVKLRGSVNPECTLAQLGAAKMWRLL--HGEAKKGYINSLGALTGGQA 77
Query 79 QQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPL-PDQSMHEKTAVPKLIAEIYTFLR 137
Q+ A + IYLSGW VAA + + PDQS++ +VP ++ I R
Sbjct 78 LQQAKAGIEA--------IYLSGWQVAADANLASSMYPDQSLYPANSVPAVVDRINNTFR 129
Query 138 QADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLL 197
+AD Q A+G IE + + +PI+AD +AGFG + L
Sbjct 130 RAD-----------QIQWASG-------IEPNDPRYVDYFLPIVADAEAGFGGVLNAFEL 171
Query 198 TKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIV 257
K MIEAGA A+ E+Q++ K+CGH GKV VP ++ + K+ A R A +GV +++
Sbjct 172 MKSMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVMGVPT-LVI 230
Query 258 ARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRL 317
ARTD++ ADL + G + + R
Sbjct 231 ARTDADAADLITSDCDPYDSGFITGE--------------------------------RT 258
Query 318 ASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLV 377
+ G Y+ G + + + AD++W ET TPD+ F + I + P L
Sbjct 259 SEGFYRTHAGIEQ---AISRGLAYAPYADLVWCETSTPDLELARRFADAIHAKYPGKLLA 315
Query 378 YNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQAD 437
YN SPSFNW N D+ I +FQ
Sbjct 316 YNCSPSFNWQKNL------------------------------------DDKTIASFQQQ 339
Query 438 AAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEI---RGGIACVK 494
+ + G + ITL H+ + +LA Y EGM YV VQ+ E + G V
Sbjct 340 LS-DMGYKYQFITLAGIHSMWFNMFDLAHAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVS 398
Query 495 HQAMAGSDIGDDHKEIFAG 513
HQ G+ D I G
Sbjct 399 HQQEVGTGYFDKVTTIIQG 417
>Q8RQN6 Isocitrate lyase [Corynebacterium efficiens (strain DSM
44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)]
Length=431
Score = 141 bits (355), Expect = 6e-40
Identities = 131/453 (29%), Positives = 190/453 (42%), Gaps = 116/453 (26%)
Query 61 ADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFG-PLPDQSM 119
A+ Y +LG G A Q++ A K +YLSGW VA + G PDQS+
Sbjct 62 AEGDDYINALGALTGNQAVQQVRAGLKA--------VYLSGWQVAGDANLAGHTYPDQSL 113
Query 120 HEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVP 179
+ +VP ++ I N L RA + A GD++ +DN+ +VP
Sbjct 114 YPANSVPNVVRRIN-----------NALLRADEIARVEGDTS--------VDNW---LVP 151
Query 180 IIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKI 239
I+AD +AGFG Y L K MI AGA E+Q++ K+CGH GKV +P + + +
Sbjct 152 IVADGEAGFGGALNVYELQKGMITAGAAGTHWEDQLASEKKCGHLGGKVLIPTQQHIRTL 211
Query 240 NAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQ 299
N+ R A ++ V++ARTD+E A L T ++D
Sbjct 212 NSARLA-ADVANTPTVVIARTDAEAATLI---------------------TSDVD----- 244
Query 300 EDEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGA---DMIWIETPTPD 356
+RD R A G Y + G + C+ ++ A DMIW+ET TPD
Sbjct 245 ------ERDRPFITGERTAEGYYHVKPGLE------PCIARAKSYAPYADMIWMETGTPD 292
Query 357 VAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSA 416
+ F ++ + P+ L YN SPSFNW+ +
Sbjct 293 LELAKKFAEGVRSEFPDQLLSYNCSPSFNWSAHL-------------------------- 326
Query 417 EYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLA 476
+ADE I FQ + G ITL +H+ +LA GY EGM A
Sbjct 327 ---------EADE-IAKFQKELG-AMGFKFQFITLAGFHSLNYGMFDLAYGY-AREGMPA 374
Query 477 YVAGVQRKEIRG----GIACVKHQAMAGSDIGD 505
+V +Q +E + G VKHQ G+ D
Sbjct 375 FV-DLQNREFKAAEERGFTAVKHQREVGAGYFD 406
>P42449 Isocitrate lyase [Corynebacterium glutamicum (strain ATCC
13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
10025)]
Length=432
Score = 140 bits (352), Expect = 2e-39
Identities = 129/452 (29%), Positives = 189/452 (42%), Gaps = 116/452 (26%)
Query 62 DNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFG-PLPDQSMH 120
+ Y +LG G A Q++ A K +YLSGW VA + G PDQS++
Sbjct 63 EGDGYINALGALTGNQAVQQVRAGLKA--------VYLSGWQVAGDANLSGHTYPDQSLY 114
Query 121 EKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPI 180
+VP ++ I N L R+ + A GD++ +DN+ VVPI
Sbjct 115 PANSVPSVVRRIN-----------NALLRSDEIARTEGDTS--------VDNW---VVPI 152
Query 181 IADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN 240
+AD +AGFG Y L K MI AGA E+Q++ K+CGH GKV +P + + +N
Sbjct 153 VADGEAGFGGALNVYELQKAMIAAGAAGTHWEDQLASEKKCGHLGGKVLIPTQQHIRTLN 212
Query 241 AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQE 300
+ R A ++ V++ARTD+E A L T ++D
Sbjct 213 SARLA-ADVANTPTVVIARTDAEAATLI---------------------TSDVD------ 244
Query 301 DEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGA---DMIWIETPTPDV 357
+RD R A G Y + G + C+ ++ A DMIW+ET TPD+
Sbjct 245 -----ERDQPFITGERTAEGYYHVKNGLE------PCIARAKSYAPYADMIWMETGTPDL 293
Query 358 AGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAE 417
F ++ + P+ L YN SPSFNW+ +
Sbjct 294 ELAKKFAEGVRSEFPDQLLSYNCSPSFNWSAHL--------------------------- 326
Query 418 YDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAY 477
+ADE I FQ + G ITL +H+ +LA GY EGM ++
Sbjct 327 --------EADE-IAKFQKELG-AMGFKFQFITLAGFHSLNYGMFDLAYGY-AREGMTSF 375
Query 478 VAGVQRKEIRG----GIACVKHQAMAGSDIGD 505
V +Q +E + G VKHQ G+ D
Sbjct 376 V-DLQNREFKAAEERGFTAVKHQREVGAGYFD 406
>P0A9G7 Isocitrate lyase [Escherichia coli O6:H1 (strain CFT073
/ ATCC 700928 / UPEC)]
Length=434
Score = 137 bits (346), Expect = 1e-38
Identities = 136/499 (27%), Positives = 203/499 (41%), Gaps = 107/499 (21%)
Query 21 WDAIRPEDAARMIVQNRFHTGLD--IAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIA 78
W+ I +A +V+ R + +A+ AA M + + + Y SLG G A
Sbjct 20 WEGITRPYSAEDVVKLRGSVNPECTLAQLGAAKMWRLL--HGESKKGYINSLGALTGGQA 77
Query 79 QQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPL-PDQSMHEKTAVPKLIAEIYTFLR 137
Q+ A + +YLSGW VAA + + PDQS++ +VP ++ I R
Sbjct 78 LQQAKAGIEA--------VYLSGWQVAADANLAASMYPDQSLYPANSVPAVVERINNTFR 129
Query 138 QADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLL 197
+AD Q +AG IE + + +PI+AD +AGFG + L
Sbjct 130 RAD-----------QIQWSAG-------IEPGDPRYVDYFLPIVADAEAGFGGVLNAFEL 171
Query 198 TKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIV 257
K MIEAGA A+ E+Q++ K+CGH GKV VP ++ + K+ A R A GV ++V
Sbjct 172 MKAMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVTGVPT-LLV 230
Query 258 ARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRL 317
ARTD++ ADL ++ + S++I+ R
Sbjct 231 ARTDADAADL-----ITSDCDPYDSEFIT---------------------------GERT 258
Query 318 ASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLV 377
+ G ++ G + + + AD++W ET TPD+ F I + P L
Sbjct 259 SEGFFRTHAGIEQ---AISRGLAYAPYADLVWCETSTPDLELARRFAQAIHAKYPGKLLA 315
Query 378 YNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQAD 437
YN SPSFNW N D+ I +FQ
Sbjct 316 YNCSPSFNWQKNL------------------------------------DDKTIASFQQQ 339
Query 438 AAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEI---RGGIACVK 494
+ + G ITL H+ + +LA Y EGM YV VQ+ E + G V
Sbjct 340 LS-DMGYKFQFITLAGIHSMWFNMFDLANAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVS 398
Query 495 HQAMAGSDIGDDHKEIFAG 513
HQ G+ D I G
Sbjct 399 HQQEVGTGYFDKVTTIIQG 417
>P0A9G6 Isocitrate lyase [Escherichia coli (strain K12)]
Length=434
Score = 137 bits (346), Expect = 1e-38
Identities = 136/499 (27%), Positives = 203/499 (41%), Gaps = 107/499 (21%)
Query 21 WDAIRPEDAARMIVQNRFHTGLD--IAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIA 78
W+ I +A +V+ R + +A+ AA M + + + Y SLG G A
Sbjct 20 WEGITRPYSAEDVVKLRGSVNPECTLAQLGAAKMWRLL--HGESKKGYINSLGALTGGQA 77
Query 79 QQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPL-PDQSMHEKTAVPKLIAEIYTFLR 137
Q+ A + +YLSGW VAA + + PDQS++ +VP ++ I R
Sbjct 78 LQQAKAGIEA--------VYLSGWQVAADANLAASMYPDQSLYPANSVPAVVERINNTFR 129
Query 138 QADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLL 197
+AD Q +AG IE + + +PI+AD +AGFG + L
Sbjct 130 RAD-----------QIQWSAG-------IEPGDPRYVDYFLPIVADAEAGFGGVLNAFEL 171
Query 198 TKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIV 257
K MIEAGA A+ E+Q++ K+CGH GKV VP ++ + K+ A R A GV ++V
Sbjct 172 MKAMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVTGVPT-LLV 230
Query 258 ARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRL 317
ARTD++ ADL ++ + S++I+ R
Sbjct 231 ARTDADAADL-----ITSDCDPYDSEFIT---------------------------GERT 258
Query 318 ASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLV 377
+ G ++ G + + + AD++W ET TPD+ F I + P L
Sbjct 259 SEGFFRTHAGIEQ---AISRGLAYAPYADLVWCETSTPDLELARRFAQAIHAKYPGKLLA 315
Query 378 YNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQAD 437
YN SPSFNW N D+ I +FQ
Sbjct 316 YNCSPSFNWQKNL------------------------------------DDKTIASFQQQ 339
Query 438 AAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEI---RGGIACVK 494
+ + G ITL H+ + +LA Y EGM YV VQ+ E + G V
Sbjct 340 LS-DMGYKFQFITLAGIHSMWFNMFDLANAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVS 398
Query 495 HQAMAGSDIGDDHKEIFAG 513
HQ G+ D I G
Sbjct 399 HQQEVGTGYFDKVTTIIQG 417
>Q6BZP5 2-methylisocitrate lyase, mitochondrial [Yarrowia lipolytica
(strain CLIB 122 / E 150)]
Length=565
Score = 138 bits (348), Expect = 3e-38
Identities = 135/498 (27%), Positives = 215/498 (43%), Gaps = 109/498 (22%)
Query 93 NKRYIYLSGWMVAALRSEFGPL-PDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRAL 151
++ +Y+SGW ++L + + PD + VP + I+ D K ++
Sbjct 117 HQEVVYISGWACSSLLTTTNEVSPDFGDYPYDTVPNQVDRIFRAQGLHDKKAWHEWMSLS 176
Query 152 QKAEAAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQI 211
+ D ++ + +ID ++ PIIAD D G G A L K E GA AI +
Sbjct 177 HEERVKRD----QEGKGRID----YLRPIIADADTGHGGLSAVMKLAKLFAERGAAAIHL 228
Query 212 ENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQ-- 269
E+Q+ K+CGH AGKV VP ++++NA R + +G +++ARTDSE A L
Sbjct 229 EDQLHGGKKCGHLAGKVIVPTGSHISRLNATRMQWDIMGC-SNLVIARTDSESAKLLSSA 287
Query 270 --------------------KIPVSKEKGDLASQYISYLD---TQEIDIADAQE------ 300
++ ++ E + ++ L+ T+E ++ E
Sbjct 288 ADPSDHEYILGVVKPIKPLAEVLLTAEANGATADMVNKLELEWTKEAEMMTYDEAVQRAL 347
Query 301 ---------DEILIKRDGKLHRPTRL----ASGLYQF--------REGTQHDRV----VL 335
+E L K GK + R +G + F REG H + +
Sbjct 348 TEAGKSDKIEEYLTKAKGKSNFEARQIADELAGKHIFFDWDAPKTREGHYHVQCGIEPAI 407
Query 336 DCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAY 395
+ AD+IW+ET TPD+A F I+++ P LVYN SPSFNW+ +
Sbjct 408 KRALAFAPYADLIWLETKTPDLAQAQAFAKRIREKFPGKWLVYNLSPSFNWSAH------ 461
Query 396 DRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYH 455
+DE++++F D A+ +G LI+L H
Sbjct 462 -----------------------------GYSDEQLKSFVWDLAK-SGFVMQLISLAGLH 491
Query 456 TAALSTHELAKGYFGEEGMLAYVAGVQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQ 515
+ A++THEL+ F EGM AYV VQRKE G + HQ +G++ D I + Q
Sbjct 492 SNAVATHELST-RFKTEGMKAYVDLVQRKEKELGCDVLTHQKWSGANYLD---SIISTVQ 547
Query 516 ALKAGDAS---KNTMNQF 530
+ +G +S +T NQF
Sbjct 548 SGSSGTSSTGGDSTENQF 565
>Q10663 Isocitrate lyase / Malate synthase [Caenorhabditis elegans]
Length=968
Score = 140 bits (352), Expect = 4e-38
Identities = 137/505 (27%), Positives = 203/505 (40%), Gaps = 106/505 (21%)
Query 5 SALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDADNS 64
+A + VK+ G + I+ + +++ R +D YT A +
Sbjct 4 AAKNFYQVVKSAPKGRFKGIKRDYTVEDVLKLRGSIDID---YTLATRGANKLWQLLHTE 60
Query 65 SYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPL-PDQSMHEKT 123
+ +LG G A Q + A K IYLSGW VAA + G + PDQS++
Sbjct 61 PFVPALGAQTGNQAVQMVRAGLKA--------IYLSGWQVAADANSAGDMYPDQSLYPAN 112
Query 124 AVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIAD 183
+ P+L I LR+AD E + + +D +Q D + PI+AD
Sbjct 113 SGPELAKRINRSLRRADQIE----------------ACEAEDYLAQRDWY----APIVAD 152
Query 184 IDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVR 243
+AGFG + L K IEAGA + E+Q+ K+CGH GKV +P + +NA R
Sbjct 153 AEAGFGGALNCFELMKAYIEAGAAGVHYEDQLGSEKKCGHMGGKVLIPTAQHIRHLNASR 212
Query 244 YAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEI 303
A GV +IVARTD+E + L D+ + Y+D
Sbjct 213 LAADVCGVPT-IIVARTDAESSRLLTS--------DIDPRDHPYID-------------- 249
Query 304 LIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGF 363
+ R G Y+ ++ T + +D D+IW+ET P +A F
Sbjct 250 --------YEAGRTIEGFYRLKDSTAI-QYCIDRAIQYAPYTDLIWMETSHPTIADAREF 300
Query 364 VNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTEL 423
+ KQ P+ YN SPSFNW + +++ EL
Sbjct 301 AEGVHKQYPDKMFAYNCSPSFNWKKHLSPSQMEKF---------------------QKEL 339
Query 424 AADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQR 483
A G + ITL YH + S +LA+ Y E+GMLAY +G+Q
Sbjct 340 GA----------------MGFKYQFITLAGYHANSYSMFDLARNY-KEKGMLAY-SGLQE 381
Query 484 KEI---RGGIACVKHQAMAGSDIGD 505
E + G VKHQ G+ D
Sbjct 382 GEFAAEKHGYTAVKHQREVGTGYFD 406
>P41554 Isocitrate lyase [Rhodococcus fascians]
Length=429
Score = 135 bits (339), Expect = 9e-38
Identities = 127/452 (28%), Positives = 184/452 (41%), Gaps = 116/452 (26%)
Query 62 DNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFG-PLPDQSMH 120
+N Y SLG G A Q++ A + IYLSGW VA + G PDQS++
Sbjct 61 NNEDYINSLGALTGNQAVQQIRAGLQA--------IYLSGWQVAGDANLSGHTYPDQSLY 112
Query 121 EKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPI 180
+VP ++ I N L RA + A+ GD++ + V PI
Sbjct 113 PANSVPSVVRRIN-----------NALLRADEIAKIEGDTS-----------VKNWVAPI 150
Query 181 IADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN 240
+AD +AGFG Y L K MI AGA + E+Q++ K+CGH GKV +P + + +
Sbjct 151 VADAEAGFGGALNAYELQKAMIVAGAAGVHWEDQLASEKKCGHLGGKVLIPTQQHIRTLT 210
Query 241 AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQE 300
+ R A ++ VI+ARTD+E A L T ++D
Sbjct 211 SARLA-SDVADVPSVIIARTDAEAATLI---------------------TSDVD------ 242
Query 301 DEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVT---SLQNGADMIWIETPTPDV 357
+RD + TR A G + + G + C+ + AD+IW+ET PD+
Sbjct 243 -----ERDREFLDGTRTAEGFFGVKNGIE------PCIARAKAYAPYADLIWMETGVPDL 291
Query 358 AGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAE 417
F ++ + P+ L YN SPSFNW A
Sbjct 292 EVAKKFSESVRSEFPDQLLAYNWSPSFNW----------------------------KAH 323
Query 418 YDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAY 477
D D I FQ + G ITL +H+ +LA GY EGM A+
Sbjct 324 LD--------DATIAKFQKELG-AMGFKFQFITLAGFHSLNYGMFDLAHGY-AREGMTAF 373
Query 478 VAGVQRKEIRG----GIACVKHQAMAGSDIGD 505
V +Q +E + G +KHQ G+ D
Sbjct 374 V-DLQEREFKAAEERGFTAIKHQREVGAGYFD 404
>Q9K9H0 Isocitrate lyase [Halalkalibacterium halodurans (strain
ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)]
Length=427
Score = 134 bits (337), Expect = 2e-37
Identities = 138/499 (28%), Positives = 203/499 (41%), Gaps = 117/499 (23%)
Query 21 WDAIRPEDAARMIVQNRFHTGLD--IAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIA 78
W + + +V+ R ++ +AK A + K + E D Y +LG G A
Sbjct 21 WQGVERPYSGEEVVKLRGSLKIEYTLAKTGAEKLWKLLHEED-----YVNALGAMTGGQA 75
Query 79 QQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPL-PDQSMHEKTAVPKLIAEIYTFLR 137
Q++ A K IYLSGW VAA + G + PDQS++ +VP ++ I L+
Sbjct 76 IQQVKAGLKA--------IYLSGWQVAADANLAGHMYPDQSLYPANSVPSVVKRINQALQ 127
Query 138 QADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLL 197
+AD +Q E G+ +D F PI+AD +AGFG + + L
Sbjct 128 RADQ---------IQHLEGEGE----------VDYF----APIVADAEAGFGGQLNVFEL 164
Query 198 TKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIV 257
K MIEAGA + E+Q++ K+CGH GKV +P + + + + R A +GV ++V
Sbjct 165 MKAMIEAGASGVHFEDQLASEKKCGHLGGKVLIPTQTAIRNLVSARLAADVMGVPT-ILV 223
Query 258 ARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRL 317
ARTD++ ADL T +ID AD + R
Sbjct 224 ARTDADAADLI---------------------TSDIDPADQ-----------RFITGERT 251
Query 318 ASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLV 377
G Y+ G + + + AD+IW ET P + F + I ++ P L
Sbjct 252 PEGFYRTNAGIEQ---AIARGLAYAPYADLIWCETSKPSLEEAKQFADAIHEKFPGKLLA 308
Query 378 YNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQAD 437
YN SPSFNW N DRA I TFQ +
Sbjct 309 YNCSPSFNWEANL------------------DRA------------------TIETFQQE 332
Query 438 AAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEIRG---GIACVK 494
+ G +TL +H S ELA GY + GM AY + +Q+ E G +
Sbjct 333 LGK-MGYKFQFVTLAGFHALNHSMFELAYGY-KQRGMGAY-SELQQAEFASEVKGYTATR 389
Query 495 HQAMAGSDIGDDHKEIFAG 513
HQ G+ D + G
Sbjct 390 HQREVGTGYFDQVAQTITG 408
>P9WKK7 Isocitrate lyase [Mycobacterium tuberculosis (strain ATCC
25618 / H37Rv)]
Length=428
Score = 127 bits (318), Expect = 6e-35
Identities = 125/472 (26%), Positives = 188/472 (40%), Gaps = 115/472 (24%)
Query 41 GLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLS 100
G + ++T A ++ + + +LG G +A Q++ A K IYLS
Sbjct 40 GSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKA--------IYLS 91
Query 101 GWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGD 159
GW VA + G PDQS++ +VP+++ I L++AD Q A+ GD
Sbjct 92 GWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRAD-----------QIAKIEGD 140
Query 160 SAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAK 219
++ E + PI+AD +AGFG Y L K +I AG E+Q++ K
Sbjct 141 TS-----------VENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEK 189
Query 220 QCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGD 279
+CGH GKV +P + + + + R A ++ V++ARTD+E A L
Sbjct 190 KCGHLGGKVLIPTQQHIRTLTSARLA-ADVADVPTVVIARTDAEAATLI----------- 237
Query 280 LASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVT 339
T ++D +RD R G Y+ + G + C+
Sbjct 238 ----------TSDVD-----------ERDQPFITGERTREGFYRTKNGIE------PCIA 270
Query 340 ---SLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYD 396
+ AD+IW+ET TPD+ F +K + P+ L YN SPSFNW +
Sbjct 271 RAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHL------ 324
Query 397 RWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHT 456
D I FQ + A G ITL +H
Sbjct 325 ------------------------------DDATIAKFQKELA-AMGFKFQFITLAGFHA 353
Query 457 AALSTHELAKGYFGEEGMLAYVAGVQRKEIRG---GIACVKHQAMAGSDIGD 505
S +LA GY + M AYV +Q +E G KHQ G+ D
Sbjct 354 LNYSMFDLAYGY-AQNQMSAYVE-LQEREFAAEERGYTATKHQREVGAGYFD 403
>P9WKK6 Isocitrate lyase 1 [Mycobacterium tuberculosis (strain
CDC 1551 / Oshkosh)]
Length=428
Score = 127 bits (318), Expect = 6e-35
Identities = 125/472 (26%), Positives = 188/472 (40%), Gaps = 115/472 (24%)
Query 41 GLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLS 100
G + ++T A ++ + + +LG G +A Q++ A K IYLS
Sbjct 40 GSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKA--------IYLS 91
Query 101 GWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGD 159
GW VA + G PDQS++ +VP+++ I L++AD Q A+ GD
Sbjct 92 GWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRAD-----------QIAKIEGD 140
Query 160 SAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAK 219
++ E + PI+AD +AGFG Y L K +I AG E+Q++ K
Sbjct 141 TS-----------VENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEK 189
Query 220 QCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGD 279
+CGH GKV +P + + + + R A ++ V++ARTD+E A L
Sbjct 190 KCGHLGGKVLIPTQQHIRTLTSARLA-ADVADVPTVVIARTDAEAATLI----------- 237
Query 280 LASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVT 339
T ++D +RD R G Y+ + G + C+
Sbjct 238 ----------TSDVD-----------ERDQPFITGERTREGFYRTKNGIE------PCIA 270
Query 340 ---SLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYD 396
+ AD+IW+ET TPD+ F +K + P+ L YN SPSFNW +
Sbjct 271 RAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHL------ 324
Query 397 RWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHT 456
D I FQ + A G ITL +H
Sbjct 325 ------------------------------DDATIAKFQKELA-AMGFKFQFITLAGFHA 353
Query 457 AALSTHELAKGYFGEEGMLAYVAGVQRKEIRG---GIACVKHQAMAGSDIGD 505
S +LA GY + M AYV +Q +E G KHQ G+ D
Sbjct 354 LNYSMFDLAYGY-AQNQMSAYVE-LQEREFAAEERGYTATKHQREVGAGYFD 403
>H8EVV4 Isocitrate lyase 1 [Mycobacterium tuberculosis (strain
ATCC 35801 / TMC 107 / Erdman)]
Length=428
Score = 127 bits (318), Expect = 6e-35
Identities = 125/472 (26%), Positives = 188/472 (40%), Gaps = 115/472 (24%)
Query 41 GLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLS 100
G + ++T A ++ + + +LG G +A Q++ A K IYLS
Sbjct 40 GSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKA--------IYLS 91
Query 101 GWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGD 159
GW VA + G PDQS++ +VP+++ I L++AD Q A+ GD
Sbjct 92 GWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRAD-----------QIAKIEGD 140
Query 160 SAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAK 219
++ E + PI+AD +AGFG Y L K +I AG E+Q++ K
Sbjct 141 TS-----------VENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEK 189
Query 220 QCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGD 279
+CGH GKV +P + + + + R A ++ V++ARTD+E A L
Sbjct 190 KCGHLGGKVLIPTQQHIRTLTSARLA-ADVADVPTVVIARTDAEAATLI----------- 237
Query 280 LASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVT 339
T ++D +RD R G Y+ + G + C+
Sbjct 238 ----------TSDVD-----------ERDQPFITGERTREGFYRTKNGIE------PCIA 270
Query 340 ---SLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYD 396
+ AD+IW+ET TPD+ F +K + P+ L YN SPSFNW +
Sbjct 271 RAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHL------ 324
Query 397 RWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHT 456
D I FQ + A G ITL +H
Sbjct 325 ------------------------------DDATIAKFQKELA-AMGFKFQFITLAGFHA 353
Query 457 AALSTHELAKGYFGEEGMLAYVAGVQRKEIRG---GIACVKHQAMAGSDIGD 505
S +LA GY + M AYV +Q +E G KHQ G+ D
Sbjct 354 LNYSMFDLAYGY-AQNQMSAYVE-LQEREFAAEERGYTATKHQREVGAGYFD 403
>P0A5H4 Isocitrate lyase 1 [Mycobacterium bovis (strain ATCC BAA-935
/ AF2122/97)]
Length=428
Score = 127 bits (318), Expect = 6e-35
Identities = 125/472 (26%), Positives = 188/472 (40%), Gaps = 115/472 (24%)
Query 41 GLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLS 100
G + ++T A ++ + + +LG G +A Q++ A K IYLS
Sbjct 40 GSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKA--------IYLS 91
Query 101 GWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGD 159
GW VA + G PDQS++ +VP+++ I L++AD Q A+ GD
Sbjct 92 GWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRAD-----------QIAKIEGD 140
Query 160 SAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAK 219
++ E + PI+AD +AGFG Y L K +I AG E+Q++ K
Sbjct 141 TS-----------VENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEK 189
Query 220 QCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGD 279
+CGH GKV +P + + + + R A ++ V++ARTD+E A L
Sbjct 190 KCGHLGGKVLIPTQQHIRTLTSARLA-ADVADVPTVVIARTDAEAATLI----------- 237
Query 280 LASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVT 339
T ++D +RD R G Y+ + G + C+
Sbjct 238 ----------TSDVD-----------ERDQPFITGERTREGFYRTKNGIE------PCIA 270
Query 340 ---SLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYD 396
+ AD+IW+ET TPD+ F +K + P+ L YN SPSFNW +
Sbjct 271 RAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHL------ 324
Query 397 RWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHT 456
D I FQ + A G ITL +H
Sbjct 325 ------------------------------DDATIAKFQKELA-AMGFKFQFITLAGFHA 353
Query 457 AALSTHELAKGYFGEEGMLAYVAGVQRKEIRG---GIACVKHQAMAGSDIGD 505
S +LA GY + M AYV +Q +E G KHQ G+ D
Sbjct 354 LNYSMFDLAYGY-AQNQMSAYVE-LQEREFAAEERGYTATKHQREVGAGYFD 403
>Q8NJ72 Isocitrate lyase [Kluyveromyces lactis (strain ATCC 8585
/ CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)]
Length=542
Score = 110 bits (274), Expect = 1e-28
Identities = 129/472 (27%), Positives = 191/472 (40%), Gaps = 67/472 (14%)
Query 97 IYLSGWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAE 155
IY+SGW ++ S P PD + + VP + ++ + D K+ + +
Sbjct 99 IYVSGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQQFHDRKQWERICDGTIE-- 156
Query 156 AAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQV 215
ES+I ++ T PI+AD DAG G A + LTK IE GA I IE+Q
Sbjct 157 -----------ESEIIDYLT---PIVADGDAGHGGLTAVFKLTKMFIERGAAGIHIEDQT 202
Query 216 SDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSK 275
S K+CGH AG+ +P ++ + ++ R A LG D ++VARTDSE A L S+
Sbjct 203 STNKKCGHMAGRCVIPVQEHINRLITCRMAADVLGSDL-ILVARTDSEAATLLSSTADSR 261
Query 276 E------------KG----DLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLAS 319
+ KG DL ++ I LD ID E E L K D KL
Sbjct 262 DHYFILGASNPAVKGKPLNDLLNKAI--LDGATIDDLQTIEKEWLAKADVKLFHEV---- 315
Query 320 GLYQFREGTQHDRVVLDCVTSLQN------------------GADMIWIETPTPDVAGIA 361
+ D+ V+D S N G ++ + G+
Sbjct 316 -FADAAKAAGKDQSVIDQFNSKVNPLSETSIYEMQALAKELLGTELFFDWDLPRGREGLY 374
Query 362 GFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYD-- 419
+ + V A+ + N+ + AEG V+A K M+
Sbjct 375 RYQGGTQCSVMRARAFAPYADLCWMESNYPDYEQAKEFAEG--VTAKFPGKWMAYNLSPS 432
Query 420 -NTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYV 478
N A DE+ TF + G ITL HT+ L+ + +K F + GM AY
Sbjct 433 FNWTKAMSVDEQ-ETF-IQRLGDLGYIWQFITLAGLHTSGLAIEQFSKN-FAKLGMKAYA 489
Query 479 AGVQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQF 530
+Q+KE+ GI VKHQ +G++ D + G A A T +QF
Sbjct 490 QDIQKKELDNGIDMVKHQKWSGAEYIDGLLRLAQGGLAATAAMGQGVTEDQF 541
Score = 18.9 bits (37), Expect = 8.5
Identities = 12/48 (25%), Positives = 20/48 (42%), Gaps = 0/48 (0%)
Query 397 RWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGV 444
RW + SAY+ AK + NT + +K+ + A+ V
Sbjct 30 RWKDTKRIYSAYEIAKRRGSVKPNTFPSTVMSQKLFKILGEHAKNGTV 77
>P28240 Isocitrate lyase [Saccharomyces cerevisiae (strain ATCC
204508 / S288c)]
Length=557
Score = 105 bits (261), Expect = 5e-27
Identities = 115/476 (24%), Positives = 203/476 (43%), Gaps = 70/476 (15%)
Query 97 IYLSGWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAE 155
IY+SGW ++ S P PD + + VP + ++ D K+L +A + E
Sbjct 103 IYISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEE 162
Query 156 AAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQV 215
+ ++ + ID ++ PI+AD DAG G A + LTK IE GA I +E+Q
Sbjct 163 -------LDEMGAPID----YLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQT 211
Query 216 SDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSK 275
S K+CGH AG+ +P ++ + ++ +R ++ + ++VARTDSE A L +S
Sbjct 212 STNKKCGHMAGRCVIPVQEHVNRLVTIRMC-ADIMHSDLIVVARTDSEAATL-----ISS 265
Query 276 EKGDLASQYISYLDTQEID-IADAQEDEILIKRDGK----LHRPTRLASGLYQFREGTQH 330
+I I+ A+ D I+ G+ + + +GL F E
Sbjct 266 TIDTRDHYFIVGATNPNIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHE---- 321
Query 331 DRVVLDCV--TSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTL 388
V+D + ++L N ++ I+ T V + + K++ AK + + F+W L
Sbjct 322 --AVIDEIERSALSNKQEL--IKKFTSKVGPLTETSHREAKKL--AKEILGHEIFFDWEL 375
Query 389 NFRQQAYDRWAA-------EGKDVSAYDRAKLMSAEYDNTELAADADEKIR--------- 432
++ R+ + + Y M + Y + + A + E ++
Sbjct 376 PRVREGLYRYRGGTQCSIMRARAFAPYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLA 435
Query 433 -----TFQADAAREAGVFHHLI-------------TLPTYHTAALSTHELAKGYFGEEGM 474
+F A H I TL HT AL+ H ++ F ++GM
Sbjct 436 YNLSPSFNWPKAMSVDEQHTFIQRLGDLGYIWQFITLAGLHTNALAVHNFSRD-FAKDGM 494
Query 475 LAYVAGVQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQF 530
AY VQ++E+ G+ +KHQ +G++ D ++ G + A + T +QF
Sbjct 495 KAYAQNVQQREMDDGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQF 550
>P41555 Isocitrate lyase [Yarrowia lipolytica (strain CLIB 122
/ E 150)]
Length=540
Score = 84.0 bits (206), Expect = 3e-20
Identities = 58/172 (34%), Positives = 89/172 (52%), Gaps = 14/172 (8%)
Query 97 IYLSGWMVAALRSEFG-PLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAE 155
IY+SGW ++ S P PD + + VP + ++ F + ++ N+ +L ++E
Sbjct 90 IYVSGWQSSSTASTSNEPSPDLADYPMDTVPNKVEHLW-FAQLFHDRKQNEERLSLPESE 148
Query 156 AAGDSAKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQV 215
+ A V ++ PIIAD D G G A LTK IE GA I IE+Q
Sbjct 149 RSKLPAPVD-----------YLRPIIADADTGHGGLTAVVKLTKMFIERGAAGIHIEDQA 197
Query 216 SDAKQCGHQAGKVTVPHEDFLAKINAVRYAFLELGVDEGVIVARTDSEGADL 267
K+CGH AGKV VP ++ + ++ A+R A ++ + + +ARTDSE A L
Sbjct 198 PGTKKCGHMAGKVLVPIQEHINRLIAIR-ASADIFGSDLLAIARTDSEAATL 248
Score = 76.6 bits (187), Expect = 7e-18
Identities = 64/215 (30%), Positives = 89/215 (41%), Gaps = 41/215 (19%)
Query 316 RLASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAK 375
R+ G Y+++ GTQ ++ + AD+IW+E+ PD A F +K VP+
Sbjct 363 RVREGYYRYQGGTQ---CAVNRGIAYAPYADLIWMESKLPDYAQAKEFAEGVKNAVPHQW 419
Query 376 LVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQ 435
L YN SPSFNWT MS E T ++ A
Sbjct 420 LAYNLSPSFNWT------------------------TAMSPEDQETYISRLA-------- 447
Query 436 ADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGVQRKEIRGGIACVKH 495
+ G ITL HT AL + + AK Y E GM AY +Q+ EI G VKH
Sbjct 448 -----KLGYVWQFITLAGLHTNALISDKFAKAY-SERGMKAYGGEIQQPEIDQGCEVVKH 501
Query 496 QAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQF 530
Q +G++ D + G A + T +QF
Sbjct 502 QKWSGAEYIDGILRMVTGGITSTAAMGAGVTEDQF 536
Lambda K H a alpha
0.318 0.133 0.386 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3817308
Database: b8dbf01f93a658702d42bec63a6f4fb9.SwissProt.fasta
Posted date: May 20, 2024 1:00 PM
Number of letters in database: 8,976
Number of sequences in database: 18
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
