BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 542ecffa46fe6d0d37f5b00cafeccf0c.SwissProt.fasta
15 sequences; 6,869 total letters
Query= ACIAD1127
Length=403
Score E
Sequences producing significant alignments: (Bits) Value
P25534 2-octaprenyl-6-methoxyphenol hydroxylase [Escherichia coli... 201 5e-64
Q2RMZ4 Ubiquinone hydroxylase UbiL [Rhodospirillum rubrum (strain... 184 3e-57
P25535 2-octaprenylphenol hydroxylase [Escherichia coli (strain K... 171 2e-52
P75728 3-demethoxyubiquinol 3-hydroxylase [Escherichia coli (stra... 138 3e-40
P72835 Uncharacterized protein slr1300 [Synechocystis sp. (strain... 136 2e-39
Q6DF46 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 120 4e-33
A1KVW0 Ubiquinone hydroxylase UbiM [Neisseria meningitidis serogr... 119 9e-33
Q54EN1 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 117 4e-32
O01884 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 116 5e-32
F1RAX8 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 110 1e-29
Q68FU7 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 102 6e-27
Q8R1S0 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 99.8 5e-26
Q9Y2Z9 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 99.4 6e-26
P53318 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial ... 70.1 3e-16
Q9S158 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydr... 65.5 1e-14
>P25534 2-octaprenyl-6-methoxyphenol hydroxylase [Escherichia
coli (strain K12)]
Length=392
Score = 201 bits (511), Expect = 5e-64
Identities = 135/401 (34%), Positives = 213/401 (53%), Gaps = 21/401 (5%)
Query 5 VIIVGGGMVGLSLALMLAKQK---IAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSRR 61
VIIVGGGM G +LAL +++ + V L+EA A + H FD R AL+
Sbjct 3 VIIVGGGMAGATLALAISRLSHGALPVHLIEAT-------APESHAHPGFDGRAIALAAG 55
Query 62 SVQIYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVL 121
+ Q ++ +W +L AT I VH++++G G L AE ++ + GQV+E +G+ L
Sbjct 56 TCQQLARIGVWQSLADCATAITTVHVSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRL 115
Query 122 LTEVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDSFCRQAL 181
+R+ + L V + + V + + G+ +L+ ++++AADG S A
Sbjct 116 FALLRKAPGVTLHCPDRVANVARTQSHVEVTLESGE---TLTGRVLVAADGTHSALATAC 172
Query 182 GIGADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVW--PVKKG 239
G+ Y+Q+A++ V TS H+ FERF++ GPLA+LP+ + R S+VW P+++
Sbjct 173 GVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPM-SDGRCSLVWCHPLERR 231
Query 240 TES-EWLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVLMGNA 298
E W +D+ F LQ +G R GK GKR +YPL+ A + R VL+GNA
Sbjct 232 EEVLSW----SDEKFCRELQSAFGWRLGKITHAGKRSAYPLALTHAARSITHRTVLVGNA 287
Query 299 AHTIHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFC 358
A T+HP+AGQGFNL +RD L L Q D+G L Y+Q R D++ I
Sbjct 288 AQTLHPIAGQGFNLGMRDVMSLAETLTQAQERGEDMGDYGVLCRYQQRRQSDREATIGVT 347
Query 359 DSVVRGFSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMG 399
DS+V F+++ L + RN GL+ ++ + ++A +G
Sbjct 348 DSLVHLFANRWAPLVVGRNIGLMTMELFTPARDVLAQRTLG 388
>Q2RMZ4 Ubiquinone hydroxylase UbiL [Rhodospirillum rubrum (strain
ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255
/ S1)]
Length=429
Score = 184 bits (468), Expect = 3e-57
Identities = 129/395 (33%), Positives = 201/395 (51%), Gaps = 13/395 (3%)
Query 5 VIIVGGGMVGLSLALMLAKQKIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSRRSVQ 64
V+IVGGG+VG +LA LA++ ++V +++ + +A LA + +D R +A++ +
Sbjct 31 VLIVGGGLVGGTLACALAEKGVSVVVIDG----EDPEALLA---AGYDGRCSAIALACQR 83
Query 65 IYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVLLTE 124
+ + LW+ L + PIL + + + GS A+ E G ++EN L + +LT
Sbjct 84 LLDTIGLWDLLGGESQPILDIRVVDGGSPLFLHY-AQAEAQGPMGYMVENRLLRQAILTR 142
Query 125 VREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDSFCRQALGIG 184
+ L+ +TAL +D + V G ++ ++LV+ ADGR S R++ GIG
Sbjct 143 LGRLPAATLLAPARMTALRRDLDGVSATLSDGQ---TVRARLVVGADGRRSQVRESAGIG 199
Query 185 ADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVWPVKKGTESEW 244
Y Q AIV V+ + H+ E F GP A+LP+PG R S+VW +
Sbjct 200 IRTLGYGQTAIVLTVEHERSHRGCAVEHFLPAGPFAILPMPGN-RSSLVWTERSDLVPGL 258
Query 245 LGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVLMGNAAHTIHP 304
L + HF L++ +GD G G RFSY L+ A++ R+ L+G+AAH +HP
Sbjct 259 LALPAE-HFQAELERRFGDHLGWVRPVGPRFSYRLTLQAANRYVDHRLALVGDAAHGMHP 317
Query 305 VAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRG 364
VAGQG N LRD VL L+ D G P L YE R D ++ D++VR
Sbjct 318 VAGQGMNYGLRDVAVLAERLVAAQRLGLDPGAPALLAEYEALRRPDNLLMLAITDALVRL 377
Query 365 FSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMG 399
FS+ + L R G+ A + + +K L +AMG
Sbjct 378 FSNDIAPVALARRLGIGAVERMGPLKRLFMRHAMG 412
>P25535 2-octaprenylphenol hydroxylase [Escherichia coli (strain
K12)]
Length=400
Score = 171 bits (432), Expect = 2e-52
Identities = 124/397 (31%), Positives = 196/397 (49%), Gaps = 11/397 (3%)
Query 5 VIIVGGGMVGLSLALMLAKQKIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSRRSVQ 64
V IVGGGMVGL++A L + V +LE R + AN P R +A++ S +
Sbjct 6 VAIVGGGMVGLAVACGLQGSGLRVAVLEQ-RVQEPLAANAPP-----QLRVSAINAASEK 59
Query 65 IYQKLELW-NALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVLLT 123
+ +L +W + L + A+ + + ++ SFG + G ++EN+ + L
Sbjct 60 LLTRLGVWQDILSRRASCYHGMEVWDKDSFGHISFDDQSMGYSHLGHIVENSVIHYALWN 119
Query 124 EVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDSFCRQALGI 183
+ + + I L+ E+ + + F+ K G L+++LVI ADG +S+ R I
Sbjct 120 KAHQSSDITLLAPAELQQVAWGENETFLTLKDGS---MLTARLVIGADGANSWLRNKADI 176
Query 184 GADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVWPVKKGTESE 243
DY A+V ++T +PH + + F G LA LPL + S+VW + E++
Sbjct 177 PLTFWDYQHHALVATIRTEEPHDAVARQVFHGEGILAFLPLSDPHLCSIVWSLSP-EEAQ 235
Query 244 WLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVLMGNAAHTIH 303
+ + ++ F AL + +R G + R +PL+ A + A R+ L+G+AAHTIH
Sbjct 236 RMQQASEDEFNRALNIAFDNRLGLCKVESARQVFPLTGRYARQFASHRLALVGDAAHTIH 295
Query 304 PVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVR 363
P+AGQG NL DA L+ L + DIGQ L YE++R ++
Sbjct 296 PLAGQGVNLGFMDAAELIAELKRLHRQGKDIGQYIYLRRYERSRKHSAALMLAGMQGFRD 355
Query 364 GFSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMGL 400
FS NP KLLR+ GL D +PG+KP + AMGL
Sbjct 356 LFSGTNPAKKLLRDIGLKLADTLPGVKPQLIRQAMGL 392
>P75728 3-demethoxyubiquinol 3-hydroxylase [Escherichia coli (strain
K12)]
Length=391
Score = 138 bits (347), Expect = 3e-40
Identities = 122/406 (30%), Positives = 188/406 (46%), Gaps = 30/406 (7%)
Query 4 QVIIVGGGMVGLSLALMLAKQKIAVKLLEAIRYPDYDDANLAPY--HSSFDARNTALSRR 61
++ IVGGGMVG +LAL LA+ AV ++E A AP+ S D R +A+S
Sbjct 7 EIAIVGGGMVGGALALGLAQHGFAVTVIE--------HAEPAPFVADSQPDVRISAISAA 58
Query 62 SVQIYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVL 121
SV + + L +W+A+Q + T + A + K+ G ++EN L + L
Sbjct 59 SVSLLKGLGVWDAVQAMRCHPYRRLETWEWETAHVVFDAAELKLPLLGYMVENTVLQQAL 118
Query 122 LTEVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDSFCRQAL 181
+ + L + ALH+ + +E K G+ + ++LVI ADG +S RQ
Sbjct 119 WQALEAHPKVTLRVPGSLIALHRHDDLQELELKGGEV---IRAKLVIGADGANSQVRQMA 175
Query 182 GIGADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVW---PVK- 237
GIG Y Q ++ +VQ +++F+ GP A LPL + S+VW P +
Sbjct 176 GIGVHAWQYAQSCMLISVQCENDPGDSTWQQFTPDGPRAFLPLFDNWA-SLVWYDSPARI 234
Query 238 ---KGTESEWLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVL 294
+ L + +HF + L AG F PL++ A + + L
Sbjct 235 RQLQNMNMAQLQAEIAKHFPSRLGYVTPLAAGAF---------PLTRRHALQYVQPGLAL 285
Query 295 MGNAAHTIHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRV 354
+G+AAHTIHP+AGQG NL RD D L+ L+ + L Y+ R+ D +
Sbjct 286 VGDAAHTIHPLAGQGVNLGYRDVDALIDVLVNARSYGEAWASYPVLKRYQMRRMADNFIM 345
Query 355 IRFCDSVVRGFSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMGL 400
D GFS+ P L+ +RN GL+A + +K YA+GL
Sbjct 346 QSGMDLFYAGFSNNLPPLRFMRNLGLMAAERAGVLKRQALKYALGL 391
>P72835 Uncharacterized protein slr1300 [Synechocystis sp. (strain
PCC 6803 / Kazusa)]
Length=414
Score = 136 bits (343), Expect = 2e-39
Identities = 110/400 (28%), Positives = 176/400 (44%), Gaps = 14/400 (4%)
Query 2 QQQVIIVGGGMVGLSLALMLAKQKIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSRR 61
Q V I GGG+VGL LA L + + ++EA+ + A P + A+S
Sbjct 12 QFDVAIAGGGVVGLVLAAGLRHTGLKIAIIEAL---PKEQALTKP-------QAYAISLL 61
Query 62 SVQIYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVL 121
S +I L +W ++ ++ I++ G E + G V E+ + + L
Sbjct 62 SGKILAGLGVWENIKDSIGHFERIQISDNDYRGTVPFAKEDVDELALGHVAEHPVILQAL 121
Query 122 LTEVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDSFCRQAL 181
V + I E+ + + ++ +++L ++L++AADG S R
Sbjct 122 ENCVEQCPRIAWFRPAELISFTAGENHKQVTLQQEGREITLQTKLLVAADGARSHTRSLA 181
Query 182 GIGADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVWPVKKGTE 241
GI Y Q + +Q P FERF + GP+ +LPLPG+ R +VW + +
Sbjct 182 GIQTKGWKYWQSCVAFTIQHQAPDNTTAFERFCDTGPMGILPLPGD-RAQIVWTMPHH-K 239
Query 242 SEWLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVLMGNAAHT 301
+ L + F+ L+Q GDR G+F R +P+ + + R+ L+G+AAH
Sbjct 240 AHTLVNLPEADFITELRQRIGDRLGEFHLINARRLFPVQLMQSDCYVQPRLALVGDAAHC 299
Query 302 IHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSV 361
HPV GQG NL +RD L + + + D G L YE R + ++ F D +
Sbjct 300 CHPVGGQGLNLGIRDGAALAQVIATAHSQGEDWGSLAVLKRYEHWRKPENWLILGFTDLL 359
Query 362 VRGF-SHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMGL 400
R F SH P + LR GL ++P K L GL
Sbjct 360 DRFFSSHWLPAI-ALRRFGLEVLRLVPPAKKLALRLMTGL 398
>Q6DF46 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Xenopus tropicalis]
Length=464
Score = 120 bits (300), Expect = 4e-33
Identities = 113/443 (26%), Positives = 190/443 (43%), Gaps = 64/443 (14%)
Query 5 VIIVGGGMVGLSLALMLAK----QKIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
V+I GGGMVG ++A L Q V LLEA +D +F R ++++
Sbjct 34 VVISGGGMVGTAMACALGSDPHLQHKKVLLLEAGNRKPFDHLP-----ENFSNRVSSITP 88
Query 61 RSVQIYQKLELWN-ALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGR 119
S + W+ L P ++ + + S A +T +++ +E G ++EN
Sbjct 89 GSATLLASFGAWDHILAMRLKPYKRMQVWDACS--DALITFDKDALEDMGYIVEND---- 142
Query 120 VLLTEVREQTLIELIDGIEVT------------ALHQDAEKVFIEAKRGDEQLSLSSQLV 167
++ E + L + D +EV + ++E + D Q L ++L+
Sbjct 143 -IIIEALTKQLELMSDHVEVMYRSRALSYSWPPPYNNGKATPWVEIELADGQ-RLHTKLL 200
Query 168 IAADGRDSFCRQALGIGADVHDYDQVAIVTAVQTSKP-HQHIGFERFSELGPLALLPLPG 226
I ADG +S R A G+ + +Y+ A+V + S+ ++ ++RF GP+ALLPL
Sbjct 201 IGADGHNSMVRSAAGMQSVQWNYNHAAVVATLHLSEATDNNVAWQRFLPTGPIALLPL-S 259
Query 227 EYRRSVVWPVKKGTESEWLGED----------------NDQHFLNALQQTYGDRAGKFEK 270
+ S+VW SE + D N F+ + F
Sbjct 260 DTCSSLVWSTSPEHASELVSMDEESFVDTVNSAFWSNENHSEFITSAGSLLHSALSFFMP 319
Query 271 TGK----------------RFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFNLCL 314
TG R S+PL A + RV L+G+AAH +HP+AGQG N+
Sbjct 320 TGSSPRQLPPSVSRVEQNSRASFPLGLKHATEYIRHRVALIGDAAHRVHPLAGQGVNMGF 379
Query 315 RDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPILKL 374
D L +L Q +D+G ++LL YE R + ++ D + R ++ + P + L
Sbjct 380 GDVACLAHHLSQAAFNGSDLGSTKHLLEYETERQRHNLPLMAAVDLLKRLYNTKQPPIVL 439
Query 375 LRNTGLIAFDVIPGIKPLVANYA 397
LR GL A + + +K + +A
Sbjct 440 LRTLGLQATNALTPVKEQIMAFA 462
>A1KVW0 Ubiquinone hydroxylase UbiM [Neisseria meningitidis serogroup
C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)]
Length=461
Score = 119 bits (297), Expect = 9e-33
Identities = 104/404 (26%), Positives = 178/404 (44%), Gaps = 17/404 (4%)
Query 1 VQQQVIIVGGGMVGLSLALMLAKQKIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
+ +++VG G GLS A LA + V L+E R P N PY D R AL+
Sbjct 70 LHSDILVVGAGPAGLSFAAELAGSGLKVTLIE--RSPLTVLQN-PPY----DGREIALTH 122
Query 61 RSVQIYQKLELWNALQQHAT-PILQVHITEQGSFGKARLT----AEQEKVESFGQVIENA 115
S +I Q+L +W+ + ++ P+ + S + A E + G +I N
Sbjct 123 FSREIMQRLGMWDKIPENEIYPLRDAKVLNGRSDYQLHFPQPTEARGEPADCLGYLISNH 182
Query 116 WLGRVLLTEVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDS 175
+ R V + + ++ V + + + + G L+++L++AAD R S
Sbjct 183 NIRRAAYEVVSQLDNVSILTDTVVKEVKTSDNEAQVILENGK---ILTARLLLAADSRFS 239
Query 176 FCRQALGIGADVHDYDQVAIVTAVQTSKPHQHIGFERFSELGPLALLPLPGEYRRSVVWP 235
R+ LGI +D+HDY + V ++ + +QH +E F +ALLPL +V+
Sbjct 240 QTRRQLGISSDMHDYSRTMFVCRMKHTLSNQHTAYECFHYGRTIALLPLEEHLTNTVITV 299
Query 236 VKKGTESEWLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRVVLM 295
S + + + ++++ R G E YPL ++A + R L+
Sbjct 300 DTDKINS--VQNLSPEELAASVKEQLKGRLGDMELVSSIHHYPLVGMIAKRFYGKRSALI 357
Query 296 GNAAHTIHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVI 355
G+AA +HPV GFNL L AD+L + +L+ DIG L Y + +
Sbjct 358 GDAAVGMHPVTAHGFNLGLSSADILAKLILEAEQRGQDIGASSLLEKYSNKHMLHAHPLY 417
Query 356 RFCDSVVRGFSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMG 399
+ +++ F+++ KLLR L A + P +K L+ G
Sbjct 418 HGTNMMLKLFTNETAPAKLLRGLVLRAGNNFPPLKKLITKQLTG 461
>Q54EN1 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Dictyostelium discoideum]
Length=495
Score = 117 bits (293), Expect = 4e-32
Identities = 102/458 (22%), Positives = 206/458 (45%), Gaps = 72/458 (16%)
Query 5 VIIVGGGMVGLSLALMLAKQK----IAVKLLEA--IRYPDYDDANLAPYHSSFDARNTAL 58
+II+GGG+VG ++A + + V L+E+ I+ + +N P + R +
Sbjct 40 IIIIGGGLVGSTMACSIGNNNTTKHLKVALIESSKIQTVEQSISNAIP-----EIRTISF 94
Query 59 SRRSVQIYQKLELWNALQ--QHATPILQVHITEQGSFGKAR-----LTAEQEKVESFGQV 111
+ +++++++ + +W+ ++ + P QV + + F + + + G +
Sbjct 95 NNQTIELFKSINVWDTIKSTKRVNPFNQVRVWDTSGFEGIHFQDNDIIDDGNNTTAMGYI 154
Query 112 IENAWLGRVLLTEVREQTLIELIDGIEVTALHQDAEKVFIEAK-------RGDEQLSLSS 164
IEN + LL++V++ IEL + + V +++ E+ D+QL +
Sbjct 155 IENNIVTSSLLSKVKQFENIELFEQLSVKSMNDYNEETIRTTSILPSVTLSNDQQLH--A 212
Query 165 QLVIAADGRDSFCRQALGIGADVHDYDQVAIVTAVQ-------------TSKPHQHIGFE 211
+L+I ADG +S ++ L + + Y+Q A+V ++ + + + F+
Sbjct 213 KLIIGADGGNSILKKQLQVPSIGRVYNQKAVVCTLKLGIKQDNNNNSSNNNNNNNNTLFQ 272
Query 212 RFSELGPLALLPLPGEYRRSVVWPVKKGTESEWLGEDNDQHFLNALQQTY-----GDRAG 266
RF GP+ALLPL Y +++W +++L E +D+ FL ++ ++ +
Sbjct 273 RFLPTGPIALLPLANGY-ANIIWSTNL-MHAQYLLELDDESFLEQVKDSFLKSPSTSNSS 330
Query 267 KFE-------------------------KTGKRFSYPLSQVLAHKQAVGRVVLMGNAAHT 301
FE KR S+PL + RV +G+A+H
Sbjct 331 FFEIASNLFNLNPKGLSGNEIYLPPIEGLVSKRASFPLRIDHTFNYTLPRVCFIGDASHL 390
Query 302 IHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSV 361
+HP+AGQG NL + D L + Q + + DIG L +E+ R + +++ D++
Sbjct 391 VHPMAGQGVNLGMADVKTLSSIIEQSVQSGYDIGDAMMLKRFEEIRKPENLKMLLSIDTL 450
Query 362 VRGFSHQNPILKLLRNTGLIAFDVIPGIKPLVANYAMG 399
F++ + + LRN G+ + I +K L+ + G
Sbjct 451 FNLFTNNSIFVTGLRNFGMSLLNNISPLKNLIIGVSKG 488
>O01884 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Caenorhabditis elegans]
Length=451
Score = 116 bits (291), Expect = 5e-32
Identities = 121/436 (28%), Positives = 191/436 (44%), Gaps = 55/436 (13%)
Query 6 IIVGGGMVGLSLALMLAKQKI----AVKLLEAIRYPDYDDANLAPYHSSFDARNTALSRR 61
+IVGGGMVG ++A L K +V LL+A R P A+ P + F+ R A S
Sbjct 21 VIVGGGMVGNAMACSLGANKSFQSKSVLLLDAGRSPSL--ASFKP-GAPFNNRVVATSPT 77
Query 62 SVQIYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGRVL 121
S+ ++KL +W+ + H T + + S + + E+ + E +IEN + L
Sbjct 78 SIDTFKKLGVWDQINSHRTKKVN-RLFVFDSCSTSEIEFERGQQEEVAFIIENDLIVGSL 136
Query 122 LTEVREQTLIELIDGIEV------TALHQDAEKVFIEAKRGDEQLSLSSQLVIAADGRDS 175
++ E +++ G +V AL A I+ + GD + + L+I ADG +S
Sbjct 137 YEKLAEYKNVDVKTGAKVEDCSIPNALENMAT---IKLENGDV---IETSLLIGADGVNS 190
Query 176 FCRQALGIGADVHDYDQVAIVTAV--QTSKPHQHIGFERFSELGPLALLPL--------- 224
R A + +Y+Q +V V +T+ ++RF+ LGP+ALLPL
Sbjct 191 KVRHASNLDYTTFNYNQHGLVAIVNIETANGKNETAWQRFTTLGPVALLPLSDTVSGLTW 250
Query 225 ---PGEYRRSVVWPVKKGTE---SEWLGEDNDQHFLN----ALQQTYGDRAGKFEKTGK- 273
P E +R P + + S ++N +N AL + R F + +
Sbjct 251 STSPEEAQRLKQLPSDQFVDELNSALFSQNNQIPLVNQTIFALNRMNPFRTETFGRKAEG 310
Query 274 -------------RFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFNLCLRDADVL 320
R S+PL AH R L+G+AAH +HP+AGQG NL D +L
Sbjct 311 TTPPHVITVQDKSRASFPLGFGNAHSYITTRCALIGDAAHRMHPLAGQGVNLGWSDVQIL 370
Query 321 VRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPILKLLRNTGL 380
+ L + DIG L Y+ A K V+ D + R + P + R GL
Sbjct 371 DKVLGDAVREGADIGSITYLREYDSAAQKHNLPVMVSVDLLNRLYRTDAPAIVAARAFGL 430
Query 381 IAFDVIPGIKPLVANY 396
AF+ + +K + NY
Sbjct 431 NAFNSLGPVKNFLMNY 446
>F1RAX8 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Danio rerio]
Length=484
Score = 110 bits (274), Expect = 1e-29
Identities = 111/440 (25%), Positives = 191/440 (43%), Gaps = 57/440 (13%)
Query 5 VIIVGGGMVGLSLALMLAKQKIA----VKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
+II GGGMVG ++A L + LLEA D ++ R +++S
Sbjct 53 IIISGGGMVGTAMACSLGLDPNLTGKKILLLEAGHEKKMDKIP-----ETYSTRVSSISP 107
Query 61 RSVQIYQKLELWNAL-QQHATPILQVHITEQGSFGKARLTAEQEKVES-FGQVIEN---- 114
S + L W+ + P ++ + + S A +T ++E ++ ++EN
Sbjct 108 GSATLLSGLGAWDHIVNMRCKPYNKMQVWDACS--DALITFDKENLQDEMAYIVENDVIV 165
Query 115 AWLGRVLLT---EVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDEQLSLSSQLVIAAD 171
A L + L T V+ Q +++ H +++ + + +L ++L+I AD
Sbjct 166 AALTKQLQTLSDHVKVQYRTKVVKYTWPHPYHVSESIPWVQVALANGK-TLHTKLLIGAD 224
Query 172 GRDSFCRQALGIGADVHDYDQVAIVTAVQTSKP-HQHIGFERFSELGPLALLPLPGEYRR 230
G +S R+ GI +YDQ A+V + S+P ++ ++RF GP+A+LPL +
Sbjct 225 GPNSMVRREAGIPTVKWNYDQSAVVAVLHLSEPTENNVAWQRFLPTGPIAMLPL-SDTES 283
Query 231 SVVWPVKKGTESEWLGEDNDQHFLNALQQTYG---------DRAGKFEKTG--------- 272
S+VW E L D ++ F++A+ + + AG +
Sbjct 284 SLVWSTSHQHAEELLQMD-EESFVDAINSAFWSNENHSELVETAGSLFRMALSVLMPDSG 342
Query 273 ---------------KRFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFNLCLRDA 317
R +PL A + RV L+G+AAH +HP+AGQG NL D
Sbjct 343 SARQLPPSVSGIGPKSRVMFPLGMGHATEYIRHRVALIGDAAHRVHPLAGQGANLGFGDV 402
Query 318 DVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPILKLLRN 377
L + L Q DIG ++LL +E R + ++ D + R +S + LLR
Sbjct 403 SYLTQVLSQAAYNGKDIGAMQHLLEFETERQRHNLPMMTAIDLMKRLYSSNTAPMVLLRT 462
Query 378 TGLIAFDVIPGIKPLVANYA 397
GL A + +P +K + +A
Sbjct 463 FGLQATNAVPPLKEQIMAFA 482
>Q68FU7 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Rattus norvegicus]
Length=476
Score = 102 bits (254), Expect = 6e-27
Identities = 109/446 (24%), Positives = 188/446 (42%), Gaps = 70/446 (16%)
Query 5 VIIVGGGMVGLSLALMLAKQ----KIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
V++ GGGMVG ++A L + LLEA L ++ R +++S
Sbjct 46 VVVSGGGMVGSAMACALGHDIHFHDKKILLLEA-----GPKKTLEKLSETYSNRVSSISL 100
Query 61 RSVQIYQKLELWNAL-QQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGR 119
S + W+ + ++ + + S +A + +++ ++ G ++EN
Sbjct 101 GSTTLLSSFGAWDHICNMRCKAFRRMQVWD--SCSEALIMFDKDNLDDMGYIVEND---- 154
Query 120 VLLTEVREQTLIELIDGIEVT--------------ALHQDAEKVFIEAKRGDEQLSLSSQ 165
V++ + +Q L + D ++V +L + V I G +L ++
Sbjct 155 VIMHAITKQ-LEAVADRVKVLYESKAVGYAWPGPFSLADSSPWVHITLGDGS---TLQTK 210
Query 166 LVIAADGRDSFCRQALGIGADVHDYDQVAIVTAVQTSK-PHQHIGFERFSELGPLALLPL 224
L+I ADG +S RQA GI +YDQ A+V + S+ ++ ++RF GP+ALLPL
Sbjct 211 LLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPL 270
Query 225 PGEYRRSVVWPVKKGTESEWLGEDNDQHFLNALQQTYGD----------------RAGKF 268
+ S+VW +E L +++ F++A+ + A
Sbjct 271 -SDTLSSLVWSTSHAHAAE-LVSMHEEEFVDAINSAFWSDVHHTDFVDSASAMVHHAVAL 328
Query 269 EKTGK-----------------RFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFN 311
K K R +PL A + RV L+G+AAH +HP+AGQG N
Sbjct 329 LKPTKVSARQLPPSVAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVN 388
Query 312 LCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPI 371
+ D L+ YL D+G +L YE R + ++ D + R +S
Sbjct 389 MGFGDISSLIHYLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSTTP 448
Query 372 LKLLRNTGLIAFDVIPGIKPLVANYA 397
L LLR GL A + + +K + +A
Sbjct 449 LVLLRTWGLQATNAVSPLKEQIMAFA 474
>Q8R1S0 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Mus musculus]
Length=476
Score = 99.8 bits (247), Expect = 5e-26
Identities = 107/444 (24%), Positives = 185/444 (42%), Gaps = 66/444 (15%)
Query 5 VIIVGGGMVGLSLALMLAKQ----KIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
V++ GGG+VG ++A L + LLEA L ++ R +++S
Sbjct 46 VVVSGGGLVGSAMACALGHDIHFHDKKILLLEA-----GPKKALEKLSETYSNRVSSISP 100
Query 61 RSVQIYQKLELWNAL-QQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWLGR 119
S + W+ + ++ + + S +A + +++ ++ G ++EN
Sbjct 101 GSTTLLSSFGAWDHICNMRCKAFRRMQVWD--SCSEALIMFDRDNLDDMGYIVEND---- 154
Query 120 VLLTEVREQTLIELIDGIEVT------------ALHQDAEKVFIEAKRGDEQLSLSSQLV 167
V++ + +Q L + D ++V A ++ GD +L ++L+
Sbjct 155 VIMYALTKQ-LEAVADRVKVLYESKAVGYSWPGAFSMADSSPWVHITLGDGS-TLQTKLL 212
Query 168 IAADGRDSFCRQALGIGADVHDYDQVAIVTAVQTSK-PHQHIGFERFSELGPLALLPLPG 226
I ADG S RQA GI YDQ A+V + S+ ++ ++RF GP+ALLPL
Sbjct 213 IGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPL-S 271
Query 227 EYRRSVVWPVKKGTESEWLGEDNDQHFLNALQQTYG---------DRAGKFEK------- 270
+ S+VW +E + D ++ F++A+ + D A +
Sbjct 272 DTLSSLVWSTSHEHAAELVSMD-EEEFVDAINSAFWSDVHHTDFVDSASAMVRHAVALLK 330
Query 271 -----------------TGKRFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFNLC 313
R +PL A + RV L+G+AAH IHP+AGQG N+
Sbjct 331 PTKVSARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMG 390
Query 314 LRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPILK 373
D LV +L D+G +L YE R + ++ D + R +S L
Sbjct 391 FGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLV 450
Query 374 LLRNTGLIAFDVIPGIKPLVANYA 397
LLR GL A + + +K + +A
Sbjct 451 LLRTWGLQATNAVSPLKEQIMAFA 474
>Q9Y2Z9 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Homo sapiens]
Length=468
Score = 99.4 bits (246), Expect = 6e-26
Identities = 104/441 (24%), Positives = 183/441 (41%), Gaps = 60/441 (14%)
Query 5 VIIVGGGMVGLSLALMLAKQ----KIAVKLLEAIRYPDYDDANLAPYHSSFDARNTALSR 60
V++ GGG+VG ++A L + LLEA L ++ R +++S
Sbjct 38 VVVSGGGLVGAAMACALGYDIHFHDKKILLLEA-----GPKKVLEKLSETYSNRVSSISP 92
Query 61 RSVQIYQKLELWNAL---QQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIENAWL 117
S + W+ + + A +QV + +A + +++ ++ G ++EN +
Sbjct 93 GSATLLSSFGAWDHICNMRYRAFRRMQVW----DACSEALIMFDKDNLDDMGYIVENDVI 148
Query 118 GRVLLTEVR----EQTLIELIDGIEVT---ALHQDAEKVFIEAKRGDEQLSLSSQLVIAA 170
L ++ T++ I T ++ GD + ++L+I A
Sbjct 149 MHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGS-TFQTKLLIGA 207
Query 171 DGRDSFCRQALGIGADVHDYDQVAIVTAVQTSK-PHQHIGFERFSELGPLALLPLPGEYR 229
DG +S RQA+GI +YDQ A+V + S+ ++ ++RF GP+ALLPL +
Sbjct 208 DGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPL-SDTL 266
Query 230 RSVVWPVKKGTESEWLGEDNDQHFLNALQQTY---GDRAGKFEKTG-------------- 272
S+VW +E + D ++ F++A+ + D + G
Sbjct 267 SSLVWSTSHEHAAELVSMD-EEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTK 325
Query 273 ----------------KRFSYPLSQVLAHKQAVGRVVLMGNAAHTIHPVAGQGFNLCLRD 316
R +PL A + RV L+G+AAH +HP+AGQG N+ D
Sbjct 326 VSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGD 385
Query 317 ADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDSVVRGFSHQNPILKLLR 376
L +L D+G +L YE R + ++ D + R +S L LLR
Sbjct 386 ISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLR 445
Query 377 NTGLIAFDVIPGIKPLVANYA 397
GL A + + +K + +A
Sbjct 446 TWGLQATNAVSPLKEQIMAFA 466
>P53318 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
[Saccharomyces cerevisiae (strain ATCC 204508 / S288c)]
Length=479
Score = 70.1 bits (170), Expect = 3e-16
Identities = 101/453 (22%), Positives = 185/453 (41%), Gaps = 76/453 (17%)
Query 5 VIIVGGGMVGLSLALMLAK----QKIAVKLLEAIRYPDYDDANLAPYHSS----FDARNT 56
V+IVGGG GL+LA + + + L++ + D L+ +++S F R
Sbjct 30 VLIVGGGPAGLTLAASIKNSPQLKDLKTTLVDMVDLKD----KLSDFYNSPPDYFTNRIV 85
Query 57 ALSRRSVQIYQKLELWNALQQHATPILQVHITEQGSFGKARLTAEQEKVESFGQVIE-NA 115
+++ RS+ + + +++T+ S KA L ++ + ++I A
Sbjct 86 SVTPRSIHFLENNAGATLMHDRIQSYDGLYVTDGCS--KATLDLARDSMLCMIEIINIQA 143
Query 116 WLGRVLLTEVREQTLIELIDGIEVTAL-HQDAEKVF----IEAKRGDEQLSLSSQLVIAA 170
L + ++ I++ID +V + H D + G+ ++L++ A
Sbjct 144 SLYNRISQYDSKKDSIDIIDNTKVVNIKHSDPNDPLSWPLVTLSNGEVY---KTRLLVGA 200
Query 171 DGRDSFCRQALGIGADVHDYDQVAIVTAVQTSKPHQHI-GFERFSELGPLALLPLPGEYR 229
DG +S R+ I + Y+ +V +++ P + G++RF GP+A LP+P E
Sbjct 201 DGFNSPTRRFSQIPSRGWMYNAYGVVASMKLEYPPFKLRGWQRFLPTGPIAHLPMP-ENN 259
Query 230 RSVVW-------------PVKKGT---ESEWLGEDNDQHFL------------------- 254
++VW P + T + ++ ED D ++
Sbjct 260 ATLVWSSSERLSRLLLSLPPESFTALINAAFVLEDADMNYYYRTLEDGSMDTDKLIEDIK 319
Query 255 -------------NALQQTYGDRAGKF-EKTGKRFSYPLSQVLAHKQAVGRVVLMGNAAH 300
+ + + Y R +KT RF PL A + RV L+G+AAH
Sbjct 320 FRTEEIYATLKDESDIDEIYPPRVVSIIDKTRARF--PLKLTHADRYCTDRVALVGDAAH 377
Query 301 TIHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQRVIRFCDS 360
T HP+AGQG N+ D LV L + + DIG +L + R ++ D
Sbjct 378 TTHPLAGQGLNMGQTDVHGLVYALEKAMERGLDIGSSLSLEPFWAERYPSNNVLLGMADK 437
Query 361 VVRGFSHQNPILKLLRNTGLIAFDVIPGIKPLV 393
+ + + P + LR GL + I +K ++
Sbjct 438 LFKLYHTNFPPVVALRTFGLNLTNKIGPVKNMI 470
>Q9S158 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
hydroxylase [Comamonas testosteroni]
Length=589
Score = 65.5 bits (158), Expect = 1e-14
Identities = 94/402 (23%), Positives = 166/402 (41%), Gaps = 42/402 (10%)
Query 5 VIIVGGGMVGLSLALMLAKQKIAVKLLEAI-RYPDYDDANLAPYHSSFDARNTALSRRSV 63
V+I+G G VGL+LA L + V + E + R DY R + S+
Sbjct 16 VLIIGAGPVGLTLANTLGMAGVRVIVAEKLPRIIDYP-------------RAIGIDDESL 62
Query 64 QIYQKLELWNALQQHATPILQVHI-TEQGSFGKARLTAEQEKVESFGQVIENAWL----G 118
+ Q L + +Q H TP + T G + + + + +G NA++
Sbjct 63 RTLQAAGLSDQVQAHITPHHWMRFYTASGQC----FASIEPRTDEYGWSRRNAFIQPQVD 118
Query 119 RVLLTEVREQTLIELIDGIEVTALHQDAEKVFIEAKRGDE-QLSLSSQLVIAADGRDSFC 177
+L ++ ++++ G E+ + QD + K D + +L ++ ++A+DG +S
Sbjct 119 DILYRGLQRFDQVQVLLGHELHSFSQDDAGITATLKDADGVERTLRAKYLVASDGGNSLV 178
Query 178 RQALGIGADVHDYDQVAIVTAVQTSK---PH--QHIGFERFSELGPLALLPLPGEYRRSV 232
R+ L + + IV V+ PH H +R P LP RR
Sbjct 179 RRMLNVAFEGRTKPNQWIVVDVRNDPLGTPHIDMHCDPQR-----PYVSAALPHGIRRFE 233
Query 233 VWPVKKGTESEWLGEDNDQHFLNALQQTYGDRAGKFEKTGKRFSYPLSQVLAHKQAVGRV 292
+ TE + +N L L + K + KR Y + LA + V R+
Sbjct 234 FMVMPGETEEQLSRPEN----LAQLMRKVVADPDKVDYIRKRV-YTHNARLAAQFRVDRI 288
Query 293 VLMGNAAHTIHPVAGQGFNLCLRDADVLVRYLLQQLATSNDIGQPENLLAYEQARLKDQQ 352
+L G+AAH + GQG+N +RDA L L + + + L +YEQ R +
Sbjct 289 LLAGDAAHIMPVWQGQGYNSGMRDASNLAWKLAMVVKGE---ARSDLLDSYEQERRDHAR 345
Query 353 RVIRFCDSVVRGFSHQNPILKLLRNTGLIAFDVIPGIKPLVA 394
+I + F+ ++ +R+T ++A + +P +K A
Sbjct 346 SMIHLSEVAGDIFAPESHTAAKVRDTVMLALNAVPPVKQYFA 387
Lambda K H a alpha
0.322 0.137 0.398 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 2148608
Database: 542ecffa46fe6d0d37f5b00cafeccf0c.SwissProt.fasta
Posted date: May 8, 2024 8:01 PM
Number of letters in database: 6,869
Number of sequences in database: 15
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
