BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 3a9ea3222745dd9171cf6830c3158df7.SwissProt.fasta
19 sequences; 10,351 total letters
Query= ACIAD1193
Length=410
Score E
Sequences producing significant alignments: (Bits) Value
Q87WD2 Chloride/fluoride channel protein [Pseudomonas syringae pv... 359 2e-124
Q57753 Uncharacterized protein MJ0305 [Methanocaldococcus jannasc... 110 7e-30
C3LVE3 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae sero... 100 4e-26
Q9KM62 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae sero... 100 4e-26
Q8ZPK5 Voltage-gated ClC-type chloride channel ClcB [Salmonella t... 99.8 5e-26
B5FHR3 Voltage-gated ClC-type chloride channel ClcB [Salmonella d... 99.4 7e-26
A5F0D5 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae sero... 99.8 7e-26
Q8Z6Y0 Voltage-gated ClC-type chloride channel ClcB [Salmonella t... 99.0 9e-26
Q87GZ9 H(+)/Cl(-) exchange transporter ClcA [Vibrio parahaemolyti... 98.6 2e-25
A7N6K9 H(+)/Cl(-) exchange transporter ClcA [Vibrio campbellii (s... 98.6 2e-25
Q7MDF0 H(+)/Cl(-) exchange transporter ClcA [Vibrio vulnificus (s... 97.8 3e-25
Q8D6J0 H(+)/Cl(-) exchange transporter ClcA [Vibrio vulnificus (s... 97.8 3e-25
P76175 Voltage-gated ClC-type chloride channel ClcB [Escherichia ... 90.1 9e-23
Q8ZRP8 H(+)/Cl(-) exchange transporter ClcA [Salmonella typhimuri... 84.7 8e-21
P37019 H(+)/Cl(-) exchange transporter ClcA [Escherichia coli (st... 79.7 3e-19
Q1ZXJ0 Chloride channel protein D [Dictyostelium discoideum] 44.3 1e-07
P35522 Chloride channel protein [Tetronarce californica] 38.1 8e-06
P21564 Chloride channel protein [Torpedo marmorata] 36.6 2e-05
Q9BMK9 Chloride channel protein clh-3 [Caenorhabditis elegans] 34.7 1e-04
>Q87WD2 Chloride/fluoride channel protein [Pseudomonas syringae
pv. tomato (strain ATCC BAA-871 / DC3000)]
Length=452
Score = 359 bits (922), Expect = 2e-124
Identities = 166/410 (40%), Positives = 266/410 (65%), Gaps = 8/410 (2%)
Query 1 MKIFPSSEYREIIQYTGYWIVVSILIGLISGVSSSLIFACFDLANKLRMAYPWLIYFLPF 60
M F E +++ Y W+ ++ L+ L++G +S+L D A + R +PW+I+ LP
Sbjct 5 MSKFRRPEQLDLLPYIAKWLALAGLVALLAGSASALFLLSLDHATQWRETHPWVIWLLPV 64
Query 61 IGLMMGYLFYYYGTPIEKGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREA 120
G +G ++ G P++ G +L+IDEIH PK +P RM P++ I +++ +FG S GRE
Sbjct 65 AGFAVGLAYHLIGKPVDAGNNLIIDEIHDPKKIVPLRMVPMVLIGTVVSHLFGASVGREG 124
Query 121 PAVQLSGALTDHLTQVFKVPHDNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLR 180
AVQ+ GAL D LT VF++ ++R++ L+A I +GFA++FG PLAGA++GLE+ ++G++R
Sbjct 125 TAVQMGGALADQLTHVFRLRREDRRVILMAGISAGFASVFGTPLAGALFGLEVLAIGRMR 184
Query 181 YSAVFPCFVSAVIASQVPEFFHIVHPHHYYVVSSFPELTSVVIISLMVAGLIFGIVARIF 240
Y A+FPC V+A++A QV + + +VH H YV+ + +++++ AG++FG+ +F
Sbjct 185 YDALFPCVVAAIVADQVGQAWGVVHTH--YVIGEVVPVQLWSVMAVVAAGIVFGLTGLLF 242
Query 241 IASIHFVSKQLNRYIRFMPFRPMVGGILIMLMTLIVGA------QTFNGLGVHSMIASFY 294
+ H + + R I + P RP GG+LI + +G+ + GLG+ S++ SF
Sbjct 243 ATATHKLGAFVKRLITYSPLRPFAGGLLIAVAVWALGSNHYIDVDKYIGLGIPSIVQSFQ 302
Query 295 HDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQWLPLPISLLAGLGLVS 354
+ D++GKM+FT +LG+GFKGGE+TPLF++G TLGNAL L LP +LAG+G V+
Sbjct 303 MPMAPWDWLGKMVFTVVSLGTGFKGGEVTPLFYIGATLGNALAPLLHLPFGMLAGIGFVA 362
Query 355 LFAGASKAPLTSIILAIELFGVSIAEYAVITCLLAYLFSGNCGLYRNQNL 404
+FAGA+ PL +I++A+ELFG IA A I C+ +YL SG+ G+Y Q +
Sbjct 363 VFAGAANTPLATIVMAMELFGPEIAPLAAIACIASYLVSGHTGIYHAQRV 412
>Q57753 Uncharacterized protein MJ0305 [Methanocaldococcus jannaschii
(strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 /
NBRC 100440)]
Length=395
Score = 110 bits (275), Expect = 7e-30
Identities = 89/375 (24%), Positives = 167/375 (45%), Gaps = 14/375 (4%)
Query 19 WIVVSILIGLISGVSSSLIFACFD-LANKLRMAYPWLIYFLPFIGLMMGYLFYYYGTPIE 77
WI ++ LIG++ G+SS +I + K + +++F+ GL + Y++ G+ I+
Sbjct 18 WIGIASLIGIVGGLSSVIIAIIIEYFPEKHNVLLIPIVFFIA--GLFVDYIYELKGSGID 75
Query 78 KGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVF 137
+ L ++ +I + L+ + I GGSAG+E P VQ S + D L ++
Sbjct 76 RVLKAL--NTNEKLTWIRGLLKVLLAGAVIAV---GGSAGKEGPCVQSSASFADELYRLL 130
Query 138 KVPHDNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSAVFPCFVSAVIASQV 197
K+ NR++ +I I G F PL AI EI Y + P +++V+ +
Sbjct 131 KLK--NRELVIITGIAGGLGGAFSAPLGTAILACEIIEHENFNYINLIPPIIASVVGYLI 188
Query 198 PEFFHIVHPHHYYVVSSFPELTSVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIRF 257
F+ I H + ++ + + ++ ++A +I + +S +
Sbjct 189 --FYLITGRKHLFNITLSYTINIHDFLLFILGAFFCSLIAHCYIKTYRKISSTFDNLKIP 246
Query 258 MPFRPMVGGILIMLMTLIVGAQTFNGLGV--HSMIASFYHDLPITDFIGKMIFTATTLGS 315
+ ++GGIL+ +++ + GL + I F + IGK++ T+ T+GS
Sbjct 247 YCIKTLIGGILVAVISYFIPEVMGMGLTLTKELFIMEFSLVFLVLLLIGKILATSFTVGS 306
Query 316 GFKGGEITPLFFVGTTLGNALGQWLPLPISLLAGLGLVSLFAGASKAPLTSIILAIELFG 375
G GG + P +G G G + + LG+ + + + APL +L E+FG
Sbjct 307 GTPGGLVFPSMCIGAISGIIFGSLIGDCSAPYIVLGIATTLSATTNAPLGGAVLCTEIFG 366
Query 376 VSIAEYAVITCLLAY 390
A A I ++ Y
Sbjct 367 FDFAVPASIGAVIGY 381
>C3LVE3 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae
serotype O1 (strain M66-2)]
Length=468
Score = 100 bits (249), Expect = 4e-26
Identities = 110/414 (27%), Positives = 185/414 (45%), Gaps = 53/414 (13%)
Query 20 IVVSILIGLISGVSSSLIFACFDLANKLRMAYP----------WLIYFLPFIGL-MMGYL 68
+ +S+L+G+++G+ + L ++ R + WL FL L +GY
Sbjct 34 LFLSLLVGILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYF 93
Query 69 FYYYGTPIEKGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSA--------GREA 120
+ P G+ I EI M P+ + + + FGG GRE
Sbjct 94 LVHRFAPEAAGSG--IPEIEGAM----DGMRPVRWWRVLPVKFFGGMGALGSGMVLGREG 147
Query 121 PAVQLSGALTDHLTQVFKVPH-DNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKL 179
P VQ+ GA+ ++ +F+V + D R L A G AA F PLAG ++ +E +
Sbjct 148 PTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGAAGGLAAAFNAPLAGIMFVIE-EMRPQF 206
Query 180 RYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS---SFPELTSVVIISLMVAGLIFG 234
RY+ +V +SAV A+ V F +++ + PEL+++ + L+ G +FG
Sbjct 207 RYTLISVRAVIISAVAANIV---FRVINGQDAVITMPQYDAPELSTLGLFLLL--GALFG 261
Query 235 IVARIF-----IASIHFVSKQLNRYIRFMPFRPMVGGILIMLMTLIVGAQTFNGLGVHSM 289
+ +F +A FV N R++ M+GG +L+ L V T G+ +
Sbjct 262 VFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCFGLLL-LYVPELTGGGISLIPT 320
Query 290 IAS--FYHDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALG----QWLP-- 341
I + + + + F+G++ T GSG GG P+ +GT G A G W P
Sbjct 321 ITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLALGTLFGYAFGLIAKMWFPEL 380
Query 342 -LPISLLAGLGLVSLFAGASKAPLTSIILAIELF-GVSIAEYAVITCLLAYLFS 393
+ + A G+ +LFA +AP+T I+L IE+ + +IT L A +F+
Sbjct 381 NIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLILPLIITSLGAVIFA 434
Score = 31.6 bits (70), Expect = 8e-04
Identities = 45/178 (25%), Positives = 71/178 (40%), Gaps = 34/178 (19%)
Query 220 SVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTL 274
SV+ +SL+V G++ G+V F ++H VS+ +++ F+P + LI
Sbjct 32 SVLFLSLLV-GILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPL--WLAAFLISAFLA 88
Query 275 IVG-------AQTFNGLGVHSMIAS--------FYHDLPITDFIGKMIFTATTLGSGFKG 319
+G A G G+ + + ++ LP+ F G LGSG
Sbjct 89 FIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPVRWWRVLPVKFFGG-----MGALGSGMVL 143
Query 320 GEITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
G P +G +G + + SLLA G A A APL I+ IE
Sbjct 144 GREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAA-GAAGGLAAAFNAPLAGIMFVIE 200
>Q9KM62 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae
serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)]
Length=468
Score = 100 bits (249), Expect = 4e-26
Identities = 110/414 (27%), Positives = 185/414 (45%), Gaps = 53/414 (13%)
Query 20 IVVSILIGLISGVSSSLIFACFDLANKLRMAYP----------WLIYFLPFIGL-MMGYL 68
+ +S+L+G+++G+ + L ++ R + WL FL L +GY
Sbjct 34 LFLSLLVGILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYF 93
Query 69 FYYYGTPIEKGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSA--------GREA 120
+ P G+ I EI M P+ + + + FGG GRE
Sbjct 94 LVHRFAPEAAGSG--IPEIEGAM----DGMRPVRWWRVLPVKFFGGMGALGSGMVLGREG 147
Query 121 PAVQLSGALTDHLTQVFKVPH-DNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKL 179
P VQ+ GA+ ++ +F+V + D R L A G AA F PLAG ++ +E +
Sbjct 148 PTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGAAGGLAAAFNAPLAGIMFVIE-EMRPQF 206
Query 180 RYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS---SFPELTSVVIISLMVAGLIFG 234
RY+ +V +SAV A+ V F +++ + PEL+++ + L+ G +FG
Sbjct 207 RYTLISVRAVIISAVAANIV---FRVINGQDAVITMPQYDAPELSTLGLFLLL--GALFG 261
Query 235 IVARIF-----IASIHFVSKQLNRYIRFMPFRPMVGGILIMLMTLIVGAQTFNGLGVHSM 289
+ +F +A FV N R++ M+GG +L+ L V T G+ +
Sbjct 262 VFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCFGLLL-LYVPELTGGGISLIPT 320
Query 290 IAS--FYHDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALG----QWLP-- 341
I + + + + F+G++ T GSG GG P+ +GT G A G W P
Sbjct 321 ITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLALGTLFGYAFGLIAKMWFPEL 380
Query 342 -LPISLLAGLGLVSLFAGASKAPLTSIILAIELF-GVSIAEYAVITCLLAYLFS 393
+ + A G+ +LFA +AP+T I+L IE+ + +IT L A +F+
Sbjct 381 NIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLILPLIITSLGAVIFA 434
Score = 31.6 bits (70), Expect = 8e-04
Identities = 45/178 (25%), Positives = 71/178 (40%), Gaps = 34/178 (19%)
Query 220 SVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTL 274
SV+ +SL+V G++ G+V F ++H VS+ +++ F+P + LI
Sbjct 32 SVLFLSLLV-GILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPL--WLAAFLISAFLA 88
Query 275 IVG-------AQTFNGLGVHSMIAS--------FYHDLPITDFIGKMIFTATTLGSGFKG 319
+G A G G+ + + ++ LP+ F G LGSG
Sbjct 89 FIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPVRWWRVLPVKFFGG-----MGALGSGMVL 143
Query 320 GEITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
G P +G +G + + SLLA G A A APL I+ IE
Sbjct 144 GREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAA-GAAGGLAAAFNAPLAGIMFVIE 200
>Q8ZPK5 Voltage-gated ClC-type chloride channel ClcB [Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=417
Score = 99.8 bits (247), Expect = 5e-26
Identities = 100/408 (25%), Positives = 183/408 (45%), Gaps = 49/408 (12%)
Query 24 ILIGLISGVSSSLIFACF-----------------DLANKLRMAYPWLIYFLPFIG-LMM 65
+LI + G+ ++L A F L N PW P +G L
Sbjct 5 LLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAA 64
Query 66 GYLFYYYGTPIEKGTHLLID--EIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAPAV 123
G L + + ++ H D E Q S + ++++L + G + GRE +
Sbjct 65 GLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMI 124
Query 124 QLSGALTDHLTQVFKVPHDNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSA 183
L+ + F P + K+++ + +G A + PLAG+++ EI G L ++
Sbjct 125 LLAALAASSFARRF-TPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEIL-FGTLMLAS 182
Query 184 VFPCFVSAVIASQVPEFFHIVHPHH--YYVVSSFPELTSVVIISLMVAGLIFGIVARIFI 241
+ P VSAV+A H+++ Y V +L + + ++ GL+ G+ + +
Sbjct 183 LGPVVVSAVVALLTT---HVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLM 239
Query 242 ASIHFVSKQLNRYIRFM---PFRPMVGGILIMLMTLIVGAQTFNGLGVHSMIASFYHDLP 298
++ N ++R P++ +GG+++ L++L+ NG +S++ SF P
Sbjct 240 ---WLMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNG---YSVVQSFLLSPP 293
Query 299 ITDFIG-----KMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQ----WLP--LPISLL 347
+ IG K++ + GSG GG TP FVG ++G LG+ WLP I++L
Sbjct 294 LFSLIGGIFVCKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAIL 353
Query 348 AGL-GLVSLFAGASKAPLTSIILAIELFG-VSIAEYAVITCLLAYLFS 393
GL G+ +L A + AP+ S ++ E+ G + +I C++A + S
Sbjct 354 LGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLS 401
>B5FHR3 Voltage-gated ClC-type chloride channel ClcB [Salmonella
dublin (strain CT_02021853)]
Length=417
Score = 99.4 bits (246), Expect = 7e-26
Identities = 100/408 (25%), Positives = 183/408 (45%), Gaps = 49/408 (12%)
Query 24 ILIGLISGVSSSLIFACF-----------------DLANKLRMAYPWLIYFLPFIG-LMM 65
+LI + G+ ++L A F L N PW P +G L
Sbjct 5 LLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAA 64
Query 66 GYLFYYYGTPIEKGTHLLID--EIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAPAV 123
G L + + ++ H D E Q S + ++++L + G + GRE +
Sbjct 65 GLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMI 124
Query 124 QLSGALTDHLTQVFKVPHDNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSA 183
L+ + F P + K+++ + +G A + PLAG+++ EI G L ++
Sbjct 125 LLAALAASSFARRF-TPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEIL-FGTLMLAS 182
Query 184 VFPCFVSAVIASQVPEFFHIVHPHH--YYVVSSFPELTSVVIISLMVAGLIFGIVARIFI 241
+ P VSAV+A H+++ Y V +L + + ++ GL+ G+ + +
Sbjct 183 LGPVVVSAVVALLTT---HLLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLM 239
Query 242 ASIHFVSKQLNRYIRFM---PFRPMVGGILIMLMTLIVGAQTFNGLGVHSMIASFYHDLP 298
++ N ++R P++ +GG+++ L++L+ NG +S++ SF P
Sbjct 240 ---WLMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNG---YSVVQSFLLSPP 293
Query 299 ITDFIG-----KMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQ----WLP--LPISLL 347
+ IG K++ + GSG GG TP FVG ++G LG+ WLP I++L
Sbjct 294 LFSLIGGIFACKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAIL 353
Query 348 AGL-GLVSLFAGASKAPLTSIILAIELFG-VSIAEYAVITCLLAYLFS 393
GL G+ +L A + AP+ S ++ E+ G + +I C++A + S
Sbjct 354 LGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLS 401
>A5F0D5 H(+)/Cl(-) exchange transporter ClcA [Vibrio cholerae
serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)]
Length=468
Score = 99.8 bits (247), Expect = 7e-26
Identities = 110/414 (27%), Positives = 185/414 (45%), Gaps = 53/414 (13%)
Query 20 IVVSILIGLISGVSSSLIFACFDLANKLRMAYP----------WLIYFLPFIGL-MMGYL 68
+ +S+L+G+++G+ + L ++ R + WL FL L +GY
Sbjct 34 LFLSLLVGILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYF 93
Query 69 FYYYGTPIEKGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSA--------GREA 120
+ P G+ I EI M P+ + + + FGG GRE
Sbjct 94 LVHRFAPEAAGSG--IPEIEGAM----DGMRPVRWWRVLPVKFFGGMGALGSGMVLGREG 147
Query 121 PAVQLSGALTDHLTQVFKVPH-DNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKL 179
P VQ+ GA+ ++ +F+V + D R L A G AA F PLAG ++ +E +
Sbjct 148 PTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGAAGGLAAAFNAPLAGIMFVIE-EMRPQF 206
Query 180 RYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS---SFPELTSVVIISLMVAGLIFG 234
RY+ +V +SAV A+ V F +++ + PEL+++ + L+ G +FG
Sbjct 207 RYTLISVRAVIISAVAANIV---FRVINGQDAVITMPQYDAPELSTLGLFLLL--GALFG 261
Query 235 IVARIF-----IASIHFVSKQLNRYIRFMPFRPMVGGILIMLMTLIVGAQTFNGLGVHSM 289
+ +F +A FV N R++ M+GG +L+ L V T G+ +
Sbjct 262 VFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCFGLLL-LYVPELTGGGISLIPT 320
Query 290 IAS--FYHDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALG----QWLP-- 341
I + + + + F+G++ T GSG GG P+ +GT G A G W P
Sbjct 321 ITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLALGTLFGYAFGLIAKVWFPEL 380
Query 342 -LPISLLAGLGLVSLFAGASKAPLTSIILAIELF-GVSIAEYAVITCLLAYLFS 393
+ + A G+ +LFA +AP+T I+L IE+ + +IT L A +F+
Sbjct 381 NIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLILPLIITSLGAVIFA 434
Score = 31.6 bits (70), Expect = 8e-04
Identities = 45/178 (25%), Positives = 71/178 (40%), Gaps = 34/178 (19%)
Query 220 SVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTL 274
SV+ +SL+V G++ G+V F ++H VS+ +++ F+P + LI
Sbjct 32 SVLFLSLLV-GILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPL--WLAAFLISAFLA 88
Query 275 IVG-------AQTFNGLGVHSMIAS--------FYHDLPITDFIGKMIFTATTLGSGFKG 319
+G A G G+ + + ++ LP+ F G LGSG
Sbjct 89 FIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPVRWWRVLPVKFFGG-----MGALGSGMVL 143
Query 320 GEITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
G P +G +G + + SLLA G A A APL I+ IE
Sbjct 144 GREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAA-GAAGGLAAAFNAPLAGIMFVIE 200
>Q8Z6Y0 Voltage-gated ClC-type chloride channel ClcB [Salmonella
typhi]
Length=417
Score = 99.0 bits (245), Expect = 9e-26
Identities = 100/408 (25%), Positives = 183/408 (45%), Gaps = 49/408 (12%)
Query 24 ILIGLISGVSSSLIFACF-----------------DLANKLRMAYPWLIYFLPFIG-LMM 65
+LI + G+ ++L A F L N PW P +G L
Sbjct 5 LLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAA 64
Query 66 GYLFYYYGTPIEKGTHLLID--EIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAPAV 123
G L + + ++ H D E Q S + ++++L + G + GRE +
Sbjct 65 GLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMI 124
Query 124 QLSGALTDHLTQVFKVPHDNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSA 183
L+ + F P + K+++ + +G A + PLAG+++ EI G L ++
Sbjct 125 LLAALAASSFARRF-TPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEIL-FGTLMLAS 182
Query 184 VFPCFVSAVIASQVPEFFHIVHPHH--YYVVSSFPELTSVVIISLMVAGLIFGIVARIFI 241
+ P VSAV+A H+++ Y V +L + + ++ GL+ G+ + +
Sbjct 183 LGPVVVSAVVALLTT---HVLNGSDSLLYTVHLTVDLYAREYVMIVSTGLVAGLWGPLLM 239
Query 242 ASIHFVSKQLNRYIRFM---PFRPMVGGILIMLMTLIVGAQTFNGLGVHSMIASFYHDLP 298
++ N ++R P++ +GG+++ L++L+ NG +S++ SF P
Sbjct 240 ---WLMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNG---YSVVQSFLLSPP 293
Query 299 ITDFIG-----KMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQ----WLP--LPISLL 347
+ IG K++ + GSG GG TP FVG ++G LG+ WLP I++L
Sbjct 294 LFSLIGGIFACKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAIL 353
Query 348 AGL-GLVSLFAGASKAPLTSIILAIELFG-VSIAEYAVITCLLAYLFS 393
GL G+ +L A + AP+ S ++ E+ G + +I C++A + S
Sbjct 354 LGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLS 401
>Q87GZ9 H(+)/Cl(-) exchange transporter ClcA [Vibrio parahaemolyticus
serotype O3:K6 (strain RIMD 2210633)]
Length=467
Score = 98.6 bits (244), Expect = 2e-25
Identities = 91/316 (29%), Positives = 153/316 (48%), Gaps = 28/316 (9%)
Query 97 RMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIAS-IGSG 155
R+ P+ F + G GRE P VQ+ GA+ +T +F+V D+ + L+AS G
Sbjct 124 RVLPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLASGAAGG 183
Query 156 FAAIFGLPLAGAIYGLEITSLGKLRYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS 213
AA F PLAG ++ +E + RYS ++ +SA++A+ V F ++ V
Sbjct 184 LAAAFNAPLAGIMFVVE-EMRPQFRYSLISIRAVIISAIMANIV---FRAINGQD--AVI 237
Query 214 SFPELTSVVIISL---MVAGLIFGIVARIF-----IASIHFVSKQLNRYIRFMPFRPMVG 265
+ P+ S + +L ++ G +FG+ IF +A FV+ N R++ ++G
Sbjct 238 TMPQYQSPALQTLWLFLLLGALFGVFGVIFNKLITVAQDSFVAIHKNDRKRYLITGSILG 297
Query 266 GILIMLMTLIVGAQTFNGLGVHSMIASFYHDLPITD--FIGKMIFTATTLGSGFKGGEIT 323
G+ +L+ L V T G+ + + + + + I FIG+++ T GSG GG
Sbjct 298 GVFGLLL-LYVPQLTGGGIALIPDVTTGNYSISILVLLFIGRVVTTLLCFGSGAPGGIFA 356
Query 324 PLFFVGTTLGNALG-------QWLPLPISLLAGLGLVSLFAGASKAPLTSIILAIELF-G 375
P+ +GT G A G L + + A G+ +LFA +AP+T I+L IE+
Sbjct 357 PMLALGTLFGYAFGASADVLLPTLDIEPGVFAIAGMGALFAATVRAPITGILLVIEMTNN 416
Query 376 VSIAEYAVITCLLAYL 391
+ +ITCL A +
Sbjct 417 YYLILPLIITCLGAVI 432
Score = 32.7 bits (73), Expect = 3e-04
Identities = 32/120 (27%), Positives = 53/120 (44%), Gaps = 19/120 (16%)
Query 101 LIFISAILTQIF----GGSAGREAPAVQLS-------GALTDHLTQVFKVPHDNRKIFLI 149
L+FI ++T + G G AP + L GA D L + +F I
Sbjct 333 LLFIGRVVTTLLCFGSGAPGGIFAPMLALGTLFGYAFGASADVLLPTLDIEPG---VFAI 389
Query 150 ASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSAVFPCFVSAVIASQV----PEFFHIVH 205
A +G+ FAA P+ G + +E+T+ L + C + AVI +Q+ P + ++H
Sbjct 390 AGMGALFAATVRAPITGILLVIEMTNNYYLILPLIITC-LGAVIVAQLLGGQPIYSQLLH 448
Score = 31.2 bits (69), Expect = 0.001
Identities = 42/175 (24%), Positives = 66/175 (38%), Gaps = 31/175 (18%)
Query 222 VIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTLIV 276
V+I + G + G V F ++HFVS+ ++R +P + +LI + +
Sbjct 33 VLIMAAIVGTLAGFVGTYFELAVHFVSETRTEWLRSEIGSVLPL--WLAAVLISALLAFI 90
Query 277 G-------AQTFNGLGVHSMIASFYHDLPI-------TDFIGKMIFTATTLGSGFKGGEI 322
G A G G+ + + + P+ F G M LGSG G
Sbjct 91 GYFLVHRFAPEAAGSGIPEIEGAMDNIRPVRWWRVLPVKFFGGM----GALGSGMVLGRE 146
Query 323 TPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
P +G +G + + SLLA G A A APL I+ +E
Sbjct 147 GPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS-GAAGGLAAAFNAPLAGIMFVVE 200
Score = 19.6 bits (39), Expect = 4.2
Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query 146 IFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLR--YSAVFPCFVSAVIASQVPEF--F 201
+ ++A+I A G A++ + T LR +V P +++AV+ S + F +
Sbjct 33 VLIMAAIVGTLAGFVGTYFELAVHFVSETRTEWLRSEIGSVLPLWLAAVLISALLAFIGY 92
Query 202 HIVH 205
+VH
Sbjct 93 FLVH 96
>A7N6K9 H(+)/Cl(-) exchange transporter ClcA [Vibrio campbellii
(strain ATCC BAA-1116)]
Length=468
Score = 98.6 bits (244), Expect = 2e-25
Identities = 88/297 (30%), Positives = 144/297 (48%), Gaps = 27/297 (9%)
Query 97 RMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIAS-IGSG 155
R+ P+ F + G GRE P VQ+ GA+ +T +F+V D+ + L+AS G
Sbjct 126 RVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLASGAAGG 185
Query 156 FAAIFGLPLAGAIYGLEITSLGKLRYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS 213
AA F PLA ++ +E + RYS ++ +SA++A+ V F ++ +
Sbjct 186 LAAAFNAPLAAIMFVVE-EMRPQFRYSLISIRAVIISAIMANIV---FRAINGQEAVITM 241
Query 214 ---SFPELTSVVIISLMVAGLIFGIVARIF-----IASIHFVSKQLNRYIRFMPFRPMVG 265
PEL S+ + L+ G +FG+ +F IA FV+ N R++ ++G
Sbjct 242 PQYQSPELQSLWLFLLL--GSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILG 299
Query 266 GILIMLMTLIVGAQTFNGLGVHSMIASFYHDLPITD--FIGKMIFTATTLGSGFKGGEIT 323
G+ +L+ L V T G+G+ I + + + I F+G++I T GSG GG
Sbjct 300 GVFGLLL-LYVPQLTGGGIGLIPDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFA 358
Query 324 PLFFVGTTLGNALG-------QWLPLPISLLAGLGLVSLFAGASKAPLTSIILAIEL 373
P+ +GT G A G L + + A G+ +LFA +AP+T I+L IE+
Sbjct 359 PMLALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAATVRAPITGILLVIEM 415
Score = 30.8 bits (68), Expect = 0.001
Identities = 30/123 (24%), Positives = 54/123 (44%), Gaps = 25/123 (20%)
Query 101 LIFISAILTQIF----GGSAGREAPAVQLS-------GALTDHLTQVFKVPHDNRKIFLI 149
++F+ ++T + G G AP + L GA D L + +F I
Sbjct 335 MLFVGRVITTLLCFGSGAPGGIFAPMLALGTLFGYAFGASADMLLPSLTIEPG---VFAI 391
Query 150 ASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSAVFPCFVS---AVIASQV----PEFFH 202
A +G+ FAA P+ G + +E+T+ Y + P ++ AVI +Q+ P +
Sbjct 392 AGMGALFAATVRAPITGILLVIEMTN----NYYLILPLIITSLGAVIVAQLLGGQPIYSQ 447
Query 203 IVH 205
++H
Sbjct 448 LLH 450
Score = 30.4 bits (67), Expect = 0.002
Identities = 45/182 (25%), Positives = 71/182 (39%), Gaps = 30/182 (16%)
Query 214 SFPELTSVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIRFMPFRPMVGGILIMLMT 273
S P SV+ ++ +V G + G+V F ++HFVS+ ++ + +G +L + +
Sbjct 28 STPTSFSVLFMAAIV-GTLAGLVGTYFEIAVHFVSETRTEWL-----KSEIGSVLPLWLA 81
Query 274 --LIVGAQTFNGLGVHSMIASFYHDLPITDFIG----------------KMIFTATTLGS 315
LI GA F G + + A I + G K LGS
Sbjct 82 AILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIRSVRWWRVIPVKFFGGMGALGS 141
Query 316 GFKGGEITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILA 370
G G P +G +G + + SLLA G A A APL +I+
Sbjct 142 GMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS-GAAGGLAAAFNAPLAAIMFV 200
Query 371 IE 372
+E
Sbjct 201 VE 202
>Q7MDF0 H(+)/Cl(-) exchange transporter ClcA [Vibrio vulnificus
(strain YJ016)]
Length=467
Score = 97.8 bits (242), Expect = 3e-25
Identities = 92/324 (28%), Positives = 153/324 (47%), Gaps = 32/324 (10%)
Query 97 RMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIAS-IGSG 155
R+ P+ F + G GRE P VQ+ GA+ +T +F+V D+ + L+AS G
Sbjct 124 RVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLASGAAGG 183
Query 156 FAAIFGLPLAGAIYGLEITSLGKLRYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS 213
AA F PLAG ++ +E + RYS ++ +SAV+A+ V F ++ +
Sbjct 184 LAAAFNAPLAGIMFVVE-EMRPQFRYSLISIRAVIISAVMANIV---FRAINGQDAVITM 239
Query 214 ---SFPELTSVVIISLMVAGLIFGIVARIF-----IASIHFVSKQLNRYIRFMPFRPMVG 265
PEL ++ + L+ G +FG+ +F +A FV+ N R++ +G
Sbjct 240 PQYQPPELKALWLFLLL--GGLFGVFGVLFNKLVTVAQDAFVALHKNDRKRYLITGTCLG 297
Query 266 GILIMLMTLIVGAQTFNGLGVHSM----IASFYHDLPITDFIGKMIFTATTLGSGFKGGE 321
GI +L+ + G G+H + ++ L + F+G+++ T GSG GG
Sbjct 298 GIFGLLLLYV---PELTGGGIHLIPDVTNGNYSVSLLVMLFVGRVLTTLICFGSGAPGGI 354
Query 322 ITPLFFVGTTLGNALGQW-------LPLPISLLAGLGLVSLFAGASKAPLTSIILAIELF 374
P+ +GT G A G LP+ + A G+ +LFA +AP+T I+L IE+
Sbjct 355 FAPMLALGTLFGYAFGATAKILLPDLPIEPGMFAIAGMGALFAATVRAPITGILLVIEMT 414
Query 375 -GVSIAEYAVITCLLAYLFSGNCG 397
+ +IT L A + + CG
Sbjct 415 NNYYLILPLIITSLGAVICAQICG 438
Score = 29.6 bits (65), Expect = 0.003
Identities = 44/177 (25%), Positives = 70/177 (40%), Gaps = 32/177 (18%)
Query 220 SVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTL 274
SV+ ++ +V G++ G+V F ++HFVS+ +++ +P + ILI
Sbjct 32 SVLFLAALV-GVLAGLVGTYFEIAVHFVSETRTEWLKSEIGHLLPL--WLAAILISAALA 88
Query 275 IVG-------AQTFNGLGVHSMIASFYHDLPI-------TDFIGKMIFTATTLGSGFKGG 320
VG A G G+ + + + P+ F G M LGSG G
Sbjct 89 FVGYFLVHRFAPEAAGSGIPEIEGAMDNIRPVRWWRVIPVKFFGGM----GALGSGMVLG 144
Query 321 EITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
P +G +G + + SLLA G A A APL I+ +E
Sbjct 145 REGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS-GAAGGLAAAFNAPLAGIMFVVE 200
>Q8D6J0 H(+)/Cl(-) exchange transporter ClcA [Vibrio vulnificus
(strain CMCP6)]
Length=467
Score = 97.8 bits (242), Expect = 3e-25
Identities = 92/324 (28%), Positives = 153/324 (47%), Gaps = 32/324 (10%)
Query 97 RMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIAS-IGSG 155
R+ P+ F + G GRE P VQ+ GA+ +T +F+V D+ + L+AS G
Sbjct 124 RVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLASGAAGG 183
Query 156 FAAIFGLPLAGAIYGLEITSLGKLRYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS 213
AA F PLAG ++ +E + RYS ++ +SAV+A+ V F ++ +
Sbjct 184 LAAAFNAPLAGIMFVVE-EMRPQFRYSLISIRAVIISAVMANIV---FRAINGQDAVITM 239
Query 214 ---SFPELTSVVIISLMVAGLIFGIVARIF-----IASIHFVSKQLNRYIRFMPFRPMVG 265
PEL ++ + L+ G +FG+ +F +A FV+ N R++ +G
Sbjct 240 PQYQPPELKALWLFLLL--GGLFGVFGVLFNKLVTVAQDAFVALHKNDRKRYLITGTCLG 297
Query 266 GILIMLMTLIVGAQTFNGLGVHSM----IASFYHDLPITDFIGKMIFTATTLGSGFKGGE 321
GI +L+ + G G+H + ++ L + F+G+++ T GSG GG
Sbjct 298 GIFGLLLLYV---PELTGGGIHLIPDVTNGNYSVSLLVMLFVGRVLTTLICFGSGAPGGI 354
Query 322 ITPLFFVGTTLGNALGQW-------LPLPISLLAGLGLVSLFAGASKAPLTSIILAIELF 374
P+ +GT G A G LP+ + A G+ +LFA +AP+T I+L IE+
Sbjct 355 FAPMLALGTLFGYAFGATAKILLPDLPIEPGMFAIAGMGALFAATVRAPITGILLVIEMT 414
Query 375 -GVSIAEYAVITCLLAYLFSGNCG 397
+ +IT L A + + CG
Sbjct 415 NNYYLILPLIITSLGAVICAQICG 438
Score = 29.6 bits (65), Expect = 0.003
Identities = 44/177 (25%), Positives = 70/177 (40%), Gaps = 32/177 (18%)
Query 220 SVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIR-----FMPFRPMVGGILIMLMTL 274
SV+ ++ +V G++ G+V F ++HFVS+ +++ +P + ILI
Sbjct 32 SVLFLAALV-GVLAGLVGTYFEIAVHFVSETRTEWLKSEIGHLLPL--WLAAILISAALA 88
Query 275 IVG-------AQTFNGLGVHSMIASFYHDLPI-------TDFIGKMIFTATTLGSGFKGG 320
VG A G G+ + + + P+ F G M LGSG G
Sbjct 89 FVGYFLVHRFAPEAAGSGIPEIEGAMDNIRPVRWWRVIPVKFFGGM----GALGSGMVLG 144
Query 321 EITPLFFVGTTLGNALGQWLPLP-----ISLLAGLGLVSLFAGASKAPLTSIILAIE 372
P +G +G + + SLLA G A A APL I+ +E
Sbjct 145 REGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS-GAAGGLAAAFNAPLAGIMFVVE 200
>P76175 Voltage-gated ClC-type chloride channel ClcB [Escherichia
coli (strain K12)]
Length=418
Score = 90.1 bits (222), Expect = 9e-23
Identities = 100/385 (26%), Positives = 167/385 (43%), Gaps = 32/385 (8%)
Query 43 LANKLRMAYPWLIYFLPFIG-LMMGYLFYYYGTPIEKGTHLLID--EIHQPKAFIPKRMS 99
L N PW P +G L G L + ++ H D E Q S
Sbjct 41 LVNAATNLSPWRRLLTPALGGLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAAS 100
Query 100 PLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIASIGSGFAAI 159
+ ++++L G + GRE + L+ Q F P K+++ +G AA
Sbjct 101 LVKSLASLLVVTSGSAIGREGAMILLAALAASCFAQRF-TPRQEWKLWIACGAAAGMAAA 159
Query 160 FGLPLAGAIYGLEITSLGKLRYSAVFPCFVSAVIASQVPEFFHIVHPHHYYVVSSFPELT 219
+ PLAG+++ E+ G + +++ P +SAV+A V + Y V S
Sbjct 160 YRAPLAGSLFIAEVL-FGTMMLASLGPVIISAVVALLVSNLINHSDALLYNVQLSVTVQA 218
Query 220 S--VVIISLMVAGLIFGIVARIFIASIH--FVSKQLNRYIRFMPFRPMVGGILIMLMTLI 275
+IIS V + G + + + H FVS +L P++ +GG+++ L++L
Sbjct 219 RDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAP-----PWQLALGGLIVGLLSLF 273
Query 276 VGAQTFNGLGVHSMIASFYHDLPITD-----FIGKMIFTATTLGSGFKGGEITPLFFVGT 330
A NG +S + SF P+ F+ K+ + GSG GG TP F+G
Sbjct 274 TPAVWGNG---YSTVQSFLTAPPLLMIIAGIFLCKLCAVLASSGSGAPGGVFTPTLFIGL 330
Query 331 TL----GNALGQWLP--LPISLLAGL-GLVSLFAGASKAPLTSIILAIELFG-VSIAEYA 382
+ G +LG W P I+LL GL G+ +L A + AP+ S ++ E+ G +
Sbjct 331 AIGMLYGRSLGLWFPDGEEITLLLGLTGMATLLAATTHAPIMSTLMICEMTGEYQLLPGL 390
Query 383 VITCLLAYLFSGNCGLYRNQNLKLH 407
+I C++A + S L+R+ + H
Sbjct 391 LIACVIASVISRT--LHRDSIYRQH 413
Score = 24.6 bits (52), Expect = 0.11
Identities = 18/58 (31%), Positives = 30/58 (52%), Gaps = 5/58 (9%)
Query 13 IQYTGYWIVVS--ILIGLISGVSSSLIFACFDLANKLRMAYPWLIYFLPFIGLMMGYL 68
+Q Y +++S +L GL + +L+ AC L++A PW L GL++G L
Sbjct 216 VQARDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAPPWQ---LALGGLIVGLL 270
>Q8ZRP8 H(+)/Cl(-) exchange transporter ClcA [Salmonella typhimurium
(strain LT2 / SGSC1412 / ATCC 700720)]
Length=473
Score = 84.7 bits (208), Expect = 8e-21
Identities = 107/416 (26%), Positives = 180/416 (43%), Gaps = 48/416 (12%)
Query 21 VVSILIGLI--------SGVSSSLIFACFDLANKLRMAYPWLIYFLPFIGLMMGYLFYYY 72
VV L GL+ S V + I A +A+ + +P L + L + M+GY
Sbjct 41 VVGTLTGLVGVAFEKAVSWVQNMRIGALVQVADHAFLLWP-LAFILSALLAMVGYFLVRK 99
Query 73 GTPIEKGTHL-----LIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAPAVQLSG 127
P G+ + ++E+ + + R+ P+ FI + T G GRE P VQ+ G
Sbjct 100 FAPEAGGSGIPEIEGALEELRPVRWW---RVLPVKFIGGMGTLGAGMVLGREGPTVQIGG 156
Query 128 ALTDHLTQVFKVPH-DNRKIFLIASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYS--AV 184
L + VF++ + R L +G +A F PLAG ++ +E + RY+ ++
Sbjct 157 NLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIE-EMRPQFRYNLISI 215
Query 185 FPCFVSAVIASQVPEFFHIVHPHHYYVVSSFPELTSVVIISL---MVAGLIFGIVARIFI 241
F +++S V F+ P + +L+ + +L ++ G+IFG V +F
Sbjct 216 KAVFTGVIMSSIVFRIFNGEAP-----IIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFN 270
Query 242 ASIHFVSKQLNRYI-----RFMPFRPMVGGILIMLMTLIVGAQTFNGLGVHSMIAS--FY 294
+ + R+ +++ +GG L ++ LI A G + + A+ F
Sbjct 271 SLVLRTQDMFQRFHGGEIKKWVLMGGAIGG-LCGILGLIEPAAAGGGFNLIPIAAAGNFS 329
Query 295 HDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQ-------WLPLPISLL 347
L + FI +++ T SG GG P+ +GT LG A G L
Sbjct 330 VGLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHLEAGTF 389
Query 348 AGLGLVSLFAGASKAPLTSIILAIELF-GVSIAEYAVITCLLAYL---FSGNCGLY 399
A G+ +L A + +APLT I+L +E+ + +ITCL A L F G LY
Sbjct 390 AIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLY 445
>P37019 H(+)/Cl(-) exchange transporter ClcA [Escherichia coli
(strain K12)]
Length=473
Score = 79.7 bits (195), Expect = 3e-19
Identities = 76/297 (26%), Positives = 138/297 (46%), Gaps = 27/297 (9%)
Query 97 RMSPLIFISAILTQIFGGSAGREAPAVQLSGALTDHLTQVFKVPHDNRKIFLIAS-IGSG 155
R+ P+ F + T G GRE P VQ+ G + + +F++ D + L+A+ +G
Sbjct 126 RVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAG 185
Query 156 FAAIFGLPLAGAIYGLEITSLGKLRYS--AVFPCFVSAVIASQVPEFFHIVHPHHYYVVS 213
AA F PLAG ++ +E + RY+ ++ F+ ++++ + F+ H +
Sbjct 186 LAAAFNAPLAGILFIIE-EMRPQFRYTLISIKAVFIGVIMSTIMYRIFN-----HEVALI 239
Query 214 SFPELTSVVIISL---MVAGLIFGIVARIFIASIHFVSKQLNRY-----IRFMPFRPMVG 265
+L+ + +L ++ G+IFGI IF + + L+R +++ +G
Sbjct 240 DVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIG 299
Query 266 GILIMLMTLIVGAQTFNGLGVHSMIAS--FYHDLPITDFIGKMIFTATTLGSGFKGGEIT 323
G L L+ + A + G + + + F + + F+ ++I T SG GG
Sbjct 300 G-LCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFA 358
Query 324 PLFFVGTTLGNALG----QWLP---LPISLLAGLGLVSLFAGASKAPLTSIILAIEL 373
P+ +GT LG A G + P L A G+ +L A + +APLT IIL +E+
Sbjct 359 PMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEM 415
Score = 34.3 bits (77), Expect = 1e-04
Identities = 29/111 (26%), Positives = 47/111 (42%), Gaps = 12/111 (11%)
Query 98 MSPLIFISAILTQIF----GGSAGREAPAVQLSGALTDHL----TQVFKVPHDNRKIFLI 149
M IF++ ++T + G G AP + L L ++F H F I
Sbjct 332 MLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAI 391
Query 150 ASIGSGFAAIFGLPLAGAIYGLEITSLGKLRYSAVFPCFVSAVIASQVPEF 200
A +G+ AA PL G I LE+T Y + P ++ + A+ + +F
Sbjct 392 AGMGALLAASIRAPLTGIILVLEMTD----NYQLILPMIITGLGATLLAQF 438
Score = 18.9 bits (37), Expect = 7.3
Identities = 6/13 (46%), Positives = 7/13 (54%), Gaps = 0/13 (0%)
Query 339 WLPLPISLLAGLG 351
W LP+ GLG
Sbjct 125 WRVLPVKFFGGLG 137
>Q1ZXJ0 Chloride channel protein D [Dictyostelium discoideum]
Length=1000
Score = 44.3 bits (103), Expect = 1e-07
Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 38/205 (19%)
Query 21 VVSILIGLISGVSSSLIFACFDLANKLRMAYPWLIYFLPFIGLMMGYLFYYYGTPIEKGT 80
+VS+ +G+ GV + AC K + + + L L + +L Y+ +
Sbjct 257 IVSLFMGIFIGVIAYFSHACVSNITKYKFKFVEAVLELD---LFLAFLTYFLLNTLLATC 313
Query 81 HLLIDEIHQPKAF---IPK--------------RMSPLI--FISAILTQIFGGSAGREAP 121
L+ ++P A IP+ +M L F+S +L G AG E P
Sbjct 314 SSLLAVYYEPTAAGSGIPEVKGYLNGTKIPHTLKMKTLWTKFLSMVLAVSSGLQAGSEGP 373
Query 122 AVQLSGALTDHLTQV------FKVPH-------DNRKIFLIASIGSGFAAIFGLPLAGAI 168
+ + + + +Q FK+P +++ F+ + G+G AA F PL G +
Sbjct 374 MIHIGAIVGNGFSQAQSKEFGFKIPFLRSFRNDKDKRDFVTSGAGAGVAAAFSAPLGGTL 433
Query 169 YGLEITSLG---KLRYSAVFPCFVS 190
+ LE S L + A F C V+
Sbjct 434 FSLEEVSSFWSIALTWRAFFCCMVA 458
Score = 25.4 bits (54), Expect = 0.072
Identities = 11/44 (25%), Positives = 18/44 (41%), Gaps = 0/44 (0%)
Query 295 HDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQ 338
H L + K + + SG + G P+ +G +GN Q
Sbjct 344 HTLKMKTLWTKFLSMVLAVSSGLQAGSEGPMIHIGAIVGNGFSQ 387
>P35522 Chloride channel protein [Tetronarce californica]
Length=810
Score = 38.1 bits (87), Expect = 8e-06
Identities = 98/462 (21%), Positives = 171/462 (37%), Gaps = 93/462 (20%)
Query 9 YREIIQYTGY-WIVVSILIGLISGVSSSL-------------IFACFDLANKLRMAY-PW 53
YR +++ G WI + +L L++ VS ++ +FA + L + Y W
Sbjct 41 YRHLVKVLGEDWIFLLLLGALMALVSWAMDFIGSRGLRFYKYLFAMVE--GNLGLQYLVW 98
Query 54 LIYFLPFIGLMMGYLFYYYGTPIEKGTHL----------LIDEIHQPKAFIPKRMSPLIF 103
+ Y P I ++ LF +P G+ + ++ E + F+ K + +
Sbjct 99 VCY--PLILILFSSLFCQIVSPQAVGSGIPELKTIIRGAVLHEYLTLRTFVAKTVGLTVA 156
Query 104 ISAILTQIFGGSAGREAPAVQLSGALTDHLTQVF-------KVPHDNRKIFLIASIGSGF 156
+SA G G+E P V ++ L Q+ + P+ R L G
Sbjct 157 LSA------GFPLGKEGPFVHIASICATLLNQLLCFISGRREEPYYLRADILTVGCALGI 210
Query 157 AAIFGLPLAGAIYGLEIT--SLGKLRY-----SAVFPCFVSAVIASQVPEFFHIVHPHHY 209
+ FG PLAG ++ +E+T G Y F F+ V++ V + +
Sbjct 211 SCCFGTPLAGVLFSIEVTCSHFGVRSYWRGFLGGAFSAFIFRVLSVWVKDTVTLTALFKT 270
Query 210 YVVSSFP----ELTSVVIISLMVA--GLIFGIVAR---IFIASIHFVSKQLNRYIRFMP- 259
P EL + II + G +F + R +F+ +FV+K L + P
Sbjct 271 NFRGDIPFDLQELPAFAIIGIASGFFGALFVYLNRQIIVFMRKKNFVTKILKKQRLIYPA 330
Query 260 ----------FRPMVG---GILIM-------LMTLIVGAQTFNGLGVHSMIASFYHDLPI 299
F P VG G +M L +T + G+ + F L I
Sbjct 331 VVTFVLATLRFPPGVGQFFGAGLMPRETINSLFDNYTWTKTIDPRGLGNSAQWFIPHLNI 390
Query 300 -----TDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNALGQWLPL--PISLLAGLGL 352
F+ A + G P+F +G LG +G+ + L P L++ L
Sbjct 391 FIVMALYFVMHFWMAALAVTMPVPCGAFVPVFNLGAVLGRFVGELMALLFPDGLVSNGNL 450
Query 353 VSLFAGASKAPLTSIILAIELFGVSIAEYAVITCLLAYLFSG 394
+ G ++I A + G +AV T ++ + +G
Sbjct 451 YHILPGE-----YAVIGAAAMTGA--VTHAVSTAVICFELTG 485
>P21564 Chloride channel protein [Torpedo marmorata]
Length=805
Score = 36.6 bits (83), Expect = 2e-05
Identities = 95/436 (22%), Positives = 162/436 (37%), Gaps = 66/436 (15%)
Query 9 YREIIQYTGY-WIVVSILIGLISGVSSSLIFA----------CFDLAN-KLRMAY-PWLI 55
YR +++ G WI + +L L++ VS ++ F F L + + Y W+
Sbjct 41 YRHLVKVLGEDWIFLLLLGALMALVSWAMDFIGSRGLRFYKYLFALVEGNIGLQYLVWVC 100
Query 56 YFLPFIGLMMGYLFYYYGTPIEKGTHL----------LIDEIHQPKAFIPKRMSPLIFIS 105
Y P ++ LF +P G+ + ++ E + F+ K + + +S
Sbjct 101 Y--PLALILFSSLFCQIVSPQAVGSGIPELKTIIRGAVLHEYLTLRTFVAKTVGLTVALS 158
Query 106 AILTQIFGGSAGREAPAVQLSGALTDHLTQVF-------KVPHDNRKIFLIASIGSGFAA 158
A G G+E P V ++ L Q+ + P+ R L G +
Sbjct 159 A------GFPLGKEGPFVHIASICATLLNQLLCFISGRREEPYYLRADILTVGCALGISC 212
Query 159 IFGLPLAGAIYGLEIT--SLGKLRY-----SAVFPCFVSAVIASQVPEFFHIVHPHHYYV 211
FG PLAG ++ +E+T G Y F F+ V++ V + +
Sbjct 213 CFGTPLAGVLFSIEVTCSHFGVRSYWRGFLGGAFSAFIFRVLSVWVKDTVTLTALFKTNF 272
Query 212 VSSFPELTSVVIISLMVAGLIFGIVARIFIASIHFVSKQLNRYIRFMPFRPMVGGILIML 271
P + M A I GI + F A ++++Q+ I FM + V IL
Sbjct 273 RGDIP-----FDLQEMPAFAIIGIASGFFGALFVYLNRQI---IVFMRKKNFVTKILKKQ 324
Query 272 MTLIVGAQTFNGLGVHSMIASFYHDLPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTT 331
+ TF ++A+ + F G + T+ S F T
Sbjct 325 RLIYPAVVTF-------VLATLRFPPGVGQFFGAGLMPRETINSLFDNYTWTKT-IDPRG 376
Query 332 LGNALGQWLP-LPISLLAGLGLVSLFAGASKAPLTSIILA--IELFGVSIAEYAVITCLL 388
LGN+ ++P L I ++ L V F A+ A + + +F + + L+
Sbjct 377 LGNSAQWFIPHLNIFIVMALYFVMHFWMAALAVTMPVPCGAFVPVFNLGAVLGRFVGELM 436
Query 389 AYLFSGNCGLYRNQNL 404
A LF GL N NL
Sbjct 437 ALLFPD--GLVSNGNL 450
>Q9BMK9 Chloride channel protein clh-3 [Caenorhabditis elegans]
Length=1001
Score = 34.7 bits (78), Expect = 1e-04
Identities = 56/262 (21%), Positives = 107/262 (41%), Gaps = 49/262 (19%)
Query 19 WIVVSILIGLISGVSSSLIFACFDLAN------KLRMAYPWLIYFLPFIGLMMGYLFY-- 70
WI +++L +++ +S + +A +L N L Y + + +L ++G ++G +
Sbjct 52 WIFLALLGFIMASLSFGMDYAILNLQNGQMRLFDLVKEYHFTLAYLVWVGYVVGLILLSA 111
Query 71 ---YY------GTPIEKGTHLLIDEIHQPKAFIPKRMSPLIFISAILTQIFGGSAGREAP 121
+Y G+ I + +L I + + +S +I ++ L G G+E P
Sbjct 112 VCAHYIAPQAIGSGIPEMKTILRGVILKEYLSVRTLLSKMIGLTLSLGS--GLPMGKEGP 169
Query 122 AVQLSGALTDHLTQVFKVPHDNRKIF---------LIASIGSGFAAIFGLPLAGAIYGLE 172
V ++ + LT++ V + IF L A G A F P+ G ++ +E
Sbjct 170 FVHVASVVASQLTRL--VHGSSGGIFENESRSGEMLAAGCAVGVACTFSAPIGGVLFSIE 227
Query 173 ITSLGKLRYSAVFPCFVSAVIASQVPEFFHIVHPH----------HYYVVSSFPELTSVV 222
+TS+ Y AV + A+ F I+ HY ++FP +
Sbjct 228 VTSV----YFAVRNYWRGFFAATCSATLFRILRMFSVSAAVTVEAHYQ--TNFPPQNVFL 281
Query 223 IISLMV---AGLIFGIVARIFI 241
L + GL+ G+ IF+
Sbjct 282 PQELPIFALIGLVCGLAGSIFV 303
Score = 23.5 bits (49), Expect = 0.28
Identities = 12/40 (30%), Positives = 19/40 (48%), Gaps = 0/40 (0%)
Query 297 LPITDFIGKMIFTATTLGSGFKGGEITPLFFVGTTLGNAL 336
L + + KMI +LGSG G+ P V + + + L
Sbjct 142 LSVRTLLSKMIGLTLSLGSGLPMGKEGPFVHVASVVASQL 181
Lambda K H a alpha
0.331 0.146 0.447 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3319700
Database: 3a9ea3222745dd9171cf6830c3158df7.SwissProt.fasta
Posted date: May 19, 2024 10:12 PM
Number of letters in database: 10,351
Number of sequences in database: 19
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
