Comparative Genomics

ACIAD1390 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: c1940c8b6872d7d61cf3dd520378af20.SwissProt.fasta
           11 sequences; 2,545 total letters



Query= ACIAD1390

Length=221
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P45469 Putative NAD(P)-binding protein YraR [Escherichia coli (st...  97.4    1e-28
Q6BLA6 Protein FMP52, mitochondrial [Debaryomyces hansenii (strai...  90.1    8e-26
Q5AP65 Protein FMP52, mitochondrial [Candida albicans (strain SC5...  86.3    3e-24
A3LSB6 Protein FMP52-2, mitochondrial [Scheffersomyces stipitis (...  84.0    2e-23
A3LUX6 Protein FMP52-1, mitochondrial [Scheffersomyces stipitis (...  83.6    2e-23
Q9Z2G9 Oxidoreductase HTATIP2 [Mus musculus]                          82.8    6e-23
Q75AB3 Protein FMP52, mitochondrial [Eremothecium gossypii (strai...  79.7    6e-22
A2T7G9 Oxidoreductase HTATIP2 [Pongo pygmaeus]                        79.7    9e-22
A5DEZ6 Protein FMP52, mitochondrial [Meyerozyma guilliermondii (s...  78.2    3e-21
A1YER2 Oxidoreductase HTATIP2 [Gorilla gorilla gorilla]               78.2    3e-21
Q9BUP3 Oxidoreductase HTATIP2 [Homo sapiens]                          78.2    3e-21


>P45469 Putative NAD(P)-binding protein YraR [Escherichia coli 
(strain K12)]
Length=211

 Score = 97.4 bits (241),  Expect = 1e-28
 Identities = 66/197 (34%), Positives = 105/197 (53%), Gaps = 14/197 (7%)

Query  6    NKALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKSFSKVQQFVLEDFLLLNDQ  65
            ++ L+ GATGLVG  L+  L    + +AI    R+ L +           L D L    Q
Sbjct  2    SQVLITGATGLVGGHLLRMLINEPKVNAIAAPTRRPLGDMPGVFNPHDPQLSDALA---Q  58

Query  66   DVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQT---HLLLVSALGANS  122
              +     F CLG+T ++AGSK+ F   DY +    A  +  ++    H+L+VSA+GAN+
Sbjct  59   VTDPIDIVFCCLGTTRREAGSKEAFIHADYTLVVDTA--LTGRRLGAQHMLVVSAMGANA  116

Query  123  SSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIFLVVKDVIKK  182
             S  FYNRVKG++E+ L      KL+I  PS+L+G+R +QR+ E +   +F ++      
Sbjct  117  HSPFFYNRVKGEMEEALIAQNWPKLTIARPSMLLGDRSKQRMNETLFAPLFRLL------  170

Query  183  PFRYKPVTAQQLAHTMV  199
            P  +K + A+ +A  M+
Sbjct  171  PGNWKSIDARDVARVML  187


>Q6BLA6 Protein FMP52, mitochondrial [Debaryomyces hansenii (strain 
ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 
/ IGC 2968)]
Length=226

 Score = 90.1 bits (222),  Expect = 8e-26
 Identities = 64/203 (32%), Positives = 109/203 (54%), Gaps = 13/203 (6%)

Query  8    ALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKSFSKVQQFVLEDFLLLND---  64
            A +IG+TGLVG  L++   E+++F+ +  + R+ +D      KVQ  V  D     +   
Sbjct  3    AFIIGSTGLVGAQLLKVAAESNKFETVHTVSRRPVD---GRDKVQGVVETDTAKWPEVIR  59

Query  65   QDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTH-LLLVSALGANSS  123
            ++  G    FS  G+T   AG  + F  IDY IN   A   ++      +LVS+LGAN S
Sbjct  60   ENSKGVRTFFSAFGTTRADAGGVENFKKIDYGINYECAKAAKEAGIETFVLVSSLGANES  119

Query  124  SIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIFLVVKDVIK-K  182
            S++FY + KG+LE+ +  L   +  I  P  L+G+R++    + +A +IF    +++K  
Sbjct  120  SMLFYLKSKGKLENDIIALEFPRTIIIRPGALLGKRQKS---QGIANEIFQKWGNMVKGT  176

Query  183  PFRYK--PVTAQQLAHTMVVAAN  203
            PF++   P+T +++A   V  A+
Sbjct  177  PFKFTAYPITGEEVAKVAVHLAS  199


>Q5AP65 Protein FMP52, mitochondrial [Candida albicans (strain 
SC5314 / ATCC MYA-2876)]
Length=229

 Score = 86.3 bits (212),  Expect = 3e-24
 Identities = 59/169 (35%), Positives = 90/169 (53%), Gaps = 7/169 (4%)

Query  10   VIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKSFSKVQQFVLEDFL----LLNDQ  65
            ++GATGLVG  +V+  + +    +IT + R+  D   S SK++     D      ++  Q
Sbjct  5    ILGATGLVGSQIVKVAESSPAIKSITTLTRRTPDFANSSSKLKTLEESDSSKWSEIIKSQ  64

Query  66   DVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTHL-LLVSALGANSSS  124
             V+   +  S  G+T  KAGS + F  IDY IN   A   ++  + + +LVS++GAN+SS
Sbjct  65   AVSSDVY-LSAFGTTRAKAGSAENFKKIDYGINYSSAKAAKENGSKVCVLVSSMGANASS  123

Query  125  IIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILEN-VAQKI  172
               Y + KG+LED +  L      I  P  L+GER+E   L N +AQ I
Sbjct  124  PFLYMKTKGELEDDIIKLGFDHTVILRPGALLGERKESHGLGNSIAQTI  172


 Score = 16.5 bits (31),  Expect = 4.4
 Identities = 5/13 (38%), Positives = 9/13 (69%), Gaps = 0/13 (0%)

Query  5    KNKALVIGATGLV  17
            K+K +++G   LV
Sbjct  210  KDKVIIVGGDDLV  222


>A3LSB6 Protein FMP52-2, mitochondrial [Scheffersomyces stipitis 
(strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)]
Length=229

 Score = 84.0 bits (206),  Expect = 2e-23
 Identities = 55/159 (35%), Positives = 90/159 (57%), Gaps = 4/159 (3%)

Query  8    ALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKS--FSKVQQFVLEDFLLLNDQ  65
            A ++G+TGL G  ++   +++S FD I+ + R+ L +FKS     +Q+   + +  + ++
Sbjct  5    AFILGSTGLCGYQMLRFAEKSSLFDKISTVGRK-LPDFKSEKVHLIQEADSDKWPEIIEK  63

Query  66   DVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTH-LLLVSALGANSSS  124
            +  GY+  FS LGSTI  AGS + F  IDY IN   A   +       +L+SA  +N++S
Sbjct  64   EAKGYSTFFSGLGSTIGAAGSAENFERIDYGINYAAAKAAKKAGVQTFVLISAPLSNANS  123

Query  125  IIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQR  163
               Y R KG+LED +  L  ++  I  P +L+GER + R
Sbjct  124  RFLYIRTKGKLEDDIIALKFARTIILRPGILLGEREKFR  162


>A3LUX6 Protein FMP52-1, mitochondrial [Scheffersomyces stipitis 
(strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)]
Length=226

 Score = 83.6 bits (205),  Expect = 2e-23
 Identities = 61/214 (29%), Positives = 103/214 (48%), Gaps = 7/214 (3%)

Query  8    ALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKS--FSKVQQFVLEDFLLLNDQ  65
            A V+G+TGLVG  +++ L  ++ F  ++ + R+ L    S   + +++   E++  + ++
Sbjct  3    AFVLGSTGLVGLQILKVLDSSTAFKKVSTVSRR-LPSVTSGKINSIEKKESEEWPAIIEK  61

Query  66   DVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTH-LLLVSALGANSSS  124
            +   Y+  FS  G+T   AGS   F  IDY IN   A   +       +LVS +GAN+ S
Sbjct  62   EAKDYSAFFSAFGTTRAAAGSADNFKKIDYGINYEAAKAAKAAGVETFVLVSTIGANAQS  121

Query  125  IIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIFLVVKDVIKKPF  184
               Y +VKGQLE+ +  L   +  I  P +L+GER   + L N      L         F
Sbjct  122  SFLYLQVKGQLEEDIIALKFPRTIILRPGILLGERETSKGLLNNLSVGVLKYLHGTPLTF  181

Query  185  RYKPVTAQQLAHTMVVAANTQMETFKVYDNLAIQ  218
               P+   ++A    +A N   E+F+  D   ++
Sbjct  182  LGNPIFGAEVAQ---IAVNAAQESFEKGDEPVVK  212


>Q9Z2G9 Oxidoreductase HTATIP2 [Mus musculus]
Length=242

 Score = 82.8 bits (203),  Expect = 6e-23
 Identities = 63/208 (30%), Positives = 117/208 (56%), Gaps = 6/208 (3%)

Query  5    KNKAL-VIGATGLVGKSLVEQLQEASEFDAITVIVRQELD-EFKSFSKVQQFVLE-DFLL  61
            +NK++ ++GA+G  GK L++++   + F  +T+I R++L  E +++  V Q V++ + L 
Sbjct  17   QNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYKNVNQEVVDFEKLD  76

Query  62   LNDQDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQT-HLLLVSALGA  120
            +      G+   F CLG+T  KAG+ + F  +D +     A+L +     H  L+S+ GA
Sbjct  77   VYASAFQGHDVGFCCLGTTRSKAGA-EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGA  135

Query  121  NSSSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIFLVVKDVI  180
            + SS   Y +VKG++E  ++ L   +LS+F P +L+ +R+E R  E +A+K F  + D  
Sbjct  136  DKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRPGEWLARKFFGSLPDSW  195

Query  181  KKPFRYKPVT-AQQLAHTMVVAANTQME  207
               +    VT  + + + +V  ++ QME
Sbjct  196  ASGYAVPVVTVVRAMLNNLVSPSSGQME  223


>Q75AB3 Protein FMP52, mitochondrial [Eremothecium gossypii (strain 
ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)]
Length=224

 Score = 79.7 bits (195),  Expect = 6e-22
 Identities = 48/153 (31%), Positives = 87/153 (57%), Gaps = 3/153 (2%)

Query  8    ALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKSFSKVQQFVLEDFLLLNDQDV  67
            ALV+GATGL G ++++   EA+ F+ +  +VR+++    S ++V+  V E      +   
Sbjct  3    ALVVGATGLCGAAILKHAAEATSFNKVYALVRRQIPN--SAARVETIVNEQSDSWPESVP  60

Query  68   NGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTHL-LLVSALGANSSSII  126
             G    FS LG+T   AG  +  Y +D+++N   A   +++   + ++VSA+GA+ ++ +
Sbjct  61   AGVDVFFSGLGTTRANAGGLENQYKVDHDLNIAVAKAAKERGCRVCVIVSAIGASVNARL  120

Query  127  FYNRVKGQLEDYLQTLALSKLSIFHPSLLIGER  159
             YN++KG +E  L  L   +  I  P +L+GER
Sbjct  121  PYNKLKGDIERDLLALEFERTVILRPGVLLGER  153


>A2T7G9 Oxidoreductase HTATIP2 [Pongo pygmaeus]
Length=242

 Score = 79.7 bits (195),  Expect = 9e-22
 Identities = 63/209 (30%), Positives = 115/209 (55%), Gaps = 8/209 (4%)

Query  5    KNKAL-VIGATGLVGKSLVEQLQEASEFDAITVIVRQELD-EFKSFSKVQQFVLEDFLLL  62
            +NK++ ++GA+G  G+ L++++ E   F  +T+I R++L  + +++  V Q V+ DF  L
Sbjct  17   QNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVV-DFEKL  75

Query  63   ND--QDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQT-HLLLVSALG  119
            +D      G+   F CLG+T  KAG+ + F  +D +     A+L +     H  L+S+ G
Sbjct  76   DDYASAFQGHDVGFCCLGTTRVKAGA-EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKG  134

Query  120  ANSSSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIFLVVKDV  179
            A+ SS   Y +VKG++E  ++ L   + S+F P +L+ +R+E R  E + +K F  + + 
Sbjct  135  ADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPES  194

Query  180  IKKPFRYKPVT-AQQLAHTMVVAANTQME  207
                +    VT  + + + MV   + QME
Sbjct  195  WASGYSVPVVTVVRAMLNNMVRPRDKQME  223


>A5DEZ6 Protein FMP52, mitochondrial [Meyerozyma guilliermondii 
(strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 
/ NRRL Y-324)]
Length=232

 Score = 78.2 bits (191),  Expect = 3e-21
 Identities = 62/203 (31%), Positives = 101/203 (50%), Gaps = 13/203 (6%)

Query  7    KALVIGATGLVGKSLVEQLQEASEFDAITVIVRQELDEFKSFSKVQQFVLEDF-----LL  61
            +A+++G+TGLVG S ++ L E  E D+I  + R+        SK+   + +D      ++
Sbjct  2    RAILLGSTGLVGSSALKILNECKEIDSIFTVSRRAPKV--EGSKIDSVIEKDSDVWGDII  59

Query  62   LNDQDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQTH-LLLVSALGA  120
               +D + +  AF   G+T K AG  + F  IDY IN   A   +D      +LVS+  A
Sbjct  60   RKQKDNDVFISAF---GTTKKLAGGNEGFLKIDYGINYDAAKAAKDAGVKTFVLVSSGAA  116

Query  121  NSSSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQR-ILENVAQKIFLVVKDV  179
            +SSS  FY + KG+LED +  L   +  I  P +L+GER       E+   K+  +VK+ 
Sbjct  117  SSSSPFFYLKTKGKLEDDIVALKFPRTIIIRPGVLLGEREASHGFFESSLVKVASLVKNS  176

Query  180  IKKPFRYKPVTAQQLAHTMVVAA  202
            +   F   P   +++A   +  A
Sbjct  177  V-FAFPLYPAYDEEVAKAAIFTA  198


>A1YER2 Oxidoreductase HTATIP2 [Gorilla gorilla gorilla]
Length=242

 Score = 78.2 bits (191),  Expect = 3e-21
 Identities = 56/174 (32%), Positives = 101/174 (58%), Gaps = 7/174 (4%)

Query  5    KNKAL-VIGATGLVGKSLVEQLQEASEFDAITVIVRQELD-EFKSFSKVQQFVLEDFLLL  62
            +NK++ ++GA+G  G+ L++++ E   F  +T+I R++L  + +++  V Q V+ DF  L
Sbjct  17   QNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVV-DFEKL  75

Query  63   ND--QDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQT-HLLLVSALG  119
            +D      G+   F CLG+T  KAG+ + F  +D +     A+L +     H  L+S+ G
Sbjct  76   DDYASAFQGHDVGFCCLGTTRGKAGA-EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKG  134

Query  120  ANSSSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIF  173
            A+ SS   Y +VKG++E  ++ L   + S+F P +L+ +R+E R  E + +K F
Sbjct  135  ADKSSKFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFF  188


>Q9BUP3 Oxidoreductase HTATIP2 [Homo sapiens]
Length=242

 Score = 78.2 bits (191),  Expect = 3e-21
 Identities = 56/174 (32%), Positives = 101/174 (58%), Gaps = 7/174 (4%)

Query  5    KNKAL-VIGATGLVGKSLVEQLQEASEFDAITVIVRQELD-EFKSFSKVQQFVLEDFLLL  62
            +NK++ ++GA+G  G+ L++++ E   F  +T+I R++L  + +++  V Q V+ DF  L
Sbjct  17   QNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVV-DFEKL  75

Query  63   ND--QDVNGYTHAFSCLGSTIKKAGSKQKFYAIDYEINAHFADLIQDKQT-HLLLVSALG  119
            +D      G+   F CLG+T  KAG+ + F  +D +     A+L +     H  L+S+ G
Sbjct  76   DDYASAFQGHDVGFCCLGTTRGKAGA-EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKG  134

Query  120  ANSSSIIFYNRVKGQLEDYLQTLALSKLSIFHPSLLIGERREQRILENVAQKIF  173
            A+ SS   Y +VKG++E  ++ L   + S+F P +L+ +R+E R  E + +K F
Sbjct  135  ADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFF  188



Lambda      K        H        a         alpha
   0.324    0.136    0.372    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 389241


  Database: c1940c8b6872d7d61cf3dd520378af20.SwissProt.fasta
    Posted date:  May 20, 2024  1:36 PM
  Number of letters in database: 2,545
  Number of sequences in database:  11



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40