BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 2c5c1298618d1b11edc738bf8a34a572.SwissProt.fasta
16 sequences; 8,307 total letters
Query= ACIAD1604
Length=503
Score E
Sequences producing significant alignments: (Bits) Value
Q17M80 Probable methylmalonate-semialdehyde/malonate-semialdehyde... 624 0.0
Q02253 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrog... 623 0.0
Q02252 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrog... 622 0.0
Q07536 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrog... 619 0.0
Q9EQ20 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrog... 617 0.0
Q7QC84 Probable methylmalonate-semialdehyde/malonate-semialdehyde... 615 0.0
Q0WM29 Methylmalonate-semialdehyde dehydrogenase [acylating], mit... 598 0.0
Q54I10 Probable methylmalonate-semialdehyde/malonate-semialdehyde... 598 0.0
Q7KW39 Probable methylmalonate-semialdehyde/malonate-semialdehyde... 597 0.0
Q29HB2 Probable methylmalonate-semialdehyde/malonate-semialdehyde... 594 0.0
P28810 Methylmalonate-semialdehyde dehydrogenase [acylating] [Pse... 560 0.0
Q9I702 Malonate-semialdehyde dehydrogenase [Pseudomonas aeruginos... 469 1e-165
A7BJC4 Malonate-semialdehyde dehydrogenase [Bacillus subtilis sub... 430 3e-150
P42412 Malonate-semialdehyde dehydrogenase [Bacillus subtilis (st... 429 5e-150
A5YBJ3 Malonate-semialdehyde dehydrogenase [Lacticaseibacillus ca... 422 2e-147
P42236 Alpha-ketoglutaric semialdehyde dehydrogenase [Bacillus su... 267 5e-87
>Q17M80 Probable methylmalonate-semialdehyde/malonate-semialdehyde
dehydrogenase [acylating], mitochondrial [Aedes aegypti]
Length=521
Score = 624 bits (1610), Expect = 0.0
Identities = 298/486 (61%), Positives = 377/486 (78%), Gaps = 0/486 (0%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
S + T K+FIDGKF+DSKTTEW D+ +PAT +V+ RVP T +E++ A+ ++K+AFKT
Sbjct 20 STASVPTTKMFIDGKFVDSKTTEWIDLHDPATNKVVTRVPKCTQDEMESAVESSKKAFKT 79
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W T I R ++M KLQ LIR NM E+A +T EQGKTL DAEGD+ RGL+VVEH CS+
Sbjct 80 WSQTSILGRQQVMFKLQHLIRNNMSELAKNITKEQGKTLVDAEGDVLRGLQVVEHCCSIT 139
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
+LQMGE + +A+ +DTY+ PLGV AGI PFNFPAMIPLWMFP+AI CGNT ++KPSE
Sbjct 140 SLQMGETVPNIAKDMDTYSYTLPLGVTAGICPFNFPAMIPLWMFPVAITCGNTSIIKPSE 199
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ P +TMML+EL EAG P GV+NV+HG + V+ +C + IKA+SFVGS G ++Y
Sbjct 200 RVPGATMMLMELLNEAGCPPGVVNVIHGAHDAVNFICDNPTIKAVSFVGSDQAGKYIYER 259
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNW 301
AG++GKRVQS MGAKNH V+M DA++E TLN L GAAFGAAGQRCMALS AV VGE K W
Sbjct 260 AGRNGKRVQSNMGAKNHGVIMADANKENTLNQLAGAAFGAAGQRCMALSTAVFVGEAKQW 319
Query 302 VNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNG 361
+ LVE+A+ LKVNAGH P TD+GPVISP++K R+ +L+ SGV+EGA+L+LDGR +KV
Sbjct 320 IPDLVERARKLKVNAGHVPGTDVGPVISPQSKQRINELVESGVKEGAKLVLDGRSIKVEN 379
Query 362 YENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQ 421
+ENGNFVG TI VST+M+ Y EEIFGPVL + VDT+++A+ +IN NP+GNG +FT
Sbjct 380 FENGNFVGPTILTDVSTNMKCYTEEIFGPVLVCLTVDTVDEAVEMINNNPYGNGTAIFTT 439
Query 422 SGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
+GA AR F N ID+GQVG+N+PIPVP+P FSFTGSRGS +GD YGKQ V+FYTQTKT+
Sbjct 440 NGATARKFVNEIDVGQVGVNVPIPVPLPMFSFTGSRGSFMGDCHFYGKQGVKFYTQTKTV 499
Query 482 TSRWFE 487
T W E
Sbjct 500 TQLWRE 505
>Q02253 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase
[acylating], mitochondrial [Rattus norvegicus]
Length=535
Score = 623 bits (1607), Expect = 0.0
Identities = 293/487 (60%), Positives = 382/487 (78%), Gaps = 0/487 (0%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
S+ + T KLFIDGKF++SK+ +W DI NPAT EV+GRVP +T E++ A+AA K+AF
Sbjct 33 SSSSVPTVKLFIDGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMEAAVAACKRAFPA 92
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W T I +R +++L+ Q LI+ N+KEIA ++T EQGKTLADAEGD+ RGL+VVEHACSV
Sbjct 93 WADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVT 152
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
+L +GE + + + +D Y+ + PLGVCAGI PFNFPAMIPLWMFPMA+VCGNTF++KPSE
Sbjct 153 SLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSE 212
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ P +TM+L +L ++G P G LN++HG E V+ +C H DIKAISFVGS G +++
Sbjct 213 RVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFER 272
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNW 301
++GKRVQ+ MGAKNH VVMPDA++E TLN LVGAAFGAAGQRCMALS AV+VGE K W
Sbjct 273 GSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKW 332
Query 302 VNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNG 361
+ +LVE+AK L+VNAG +P D+GP+I+P+AK RV +LI+SG +EGA +LLDGR +KV G
Sbjct 333 LPELVERAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGAKEGASILLDGRKIKVKG 392
Query 362 YENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQ 421
YENGNFVG TI + V SM YKEEIFGPVL ++ +TL++AI ++N NP+GNG +FT
Sbjct 393 YENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTT 452
Query 422 SGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
+GA+AR + + +D+GQVG+N+PIPVP+P FSFTGSR S GD YGKQ +QFYTQ KTI
Sbjct 453 NGAIARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
Query 482 TSRWFED 488
TS+W E+
Sbjct 513 TSQWKEE 519
>Q02252 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase
[acylating], mitochondrial [Homo sapiens]
Length=535
Score = 622 bits (1603), Expect = 0.0
Identities = 293/481 (61%), Positives = 376/481 (78%), Gaps = 0/481 (0%)
Query 8 TAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPI 67
T KLFI GKF++SK+ +W DI NPAT EV+GRVP AT E+D AIA+ K+AF W T +
Sbjct 39 TVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSV 98
Query 68 QARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGE 127
+R +++L+ Q LI+ N+KEIA ++T EQGKTLADAEGD+ RGL+VVEHACSV +L MGE
Sbjct 99 LSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGE 158
Query 128 YIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLST 187
+ + + +D Y+ + PLGVCAGI PFNFPAMIPLWMFPMA+VCGNTF++KPSE+ P +T
Sbjct 159 TMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGAT 218
Query 188 MMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGK 247
M+L +L ++G P G LN++HG E V+ +C H DIKAISFVGS G +++ +HGK
Sbjct 219 MLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGK 278
Query 248 RVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVE 307
RVQ+ MGAKNH VVMPDA++E TLN LVGAAFGAAGQRCMALS AV+VGE K W+ +LVE
Sbjct 279 RVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVE 338
Query 308 KAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNF 367
AK L+VNAG +P D+GP+I+P+AK RV +LI+SG +EGA +LLDGR +KV GYENGNF
Sbjct 339 HAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNF 398
Query 368 VGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVAR 427
VG TI + V +M YKEEIFGPVL ++ +TL++AI ++N NP+GNG +FT +GA AR
Sbjct 399 VGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATAR 458
Query 428 TFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRWFE 487
+ + +D+GQVG+N+PIPVP+P FSFTGSR S GD YGKQ +QFYTQ KTITS+W E
Sbjct 459 KYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKE 518
Query 488 D 488
+
Sbjct 519 E 519
>Q07536 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase
[acylating], mitochondrial [Bos taurus]
Length=537
Score = 619 bits (1596), Expect = 0.0
Identities = 290/487 (60%), Positives = 379/487 (78%), Gaps = 0/487 (0%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
S+ + T KLFIDGKFI+SK+ +W DI NPAT EV+GRVP +T E+D A+++ K+ F
Sbjct 35 SSSSVPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPA 94
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W T I +R +++L+ Q LI+ N+KEIA ++ EQGKTLADAEGD+ RGL+VVEHACSV
Sbjct 95 WADTSILSRQQVLLRYQQLIKENLKEIARLIMLEQGKTLADAEGDVFRGLQVVEHACSVT 154
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
+L +G+ + + + +D Y+ + PLGVCAGI PFNFPAMIPLWMFPMA+VCGNTF++KPSE
Sbjct 155 SLMLGDTMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSE 214
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ P +TM+L +L ++G P G LN++HG E V+ +C H DIKAISFVGS G +++
Sbjct 215 RVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFER 274
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNW 301
+HGKRVQ+ MGAKNH VVMPDA++E TLN LVGAAFGAAGQRCMALS A++VGE K W
Sbjct 275 GSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKW 334
Query 302 VNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNG 361
+ +LVE+AK L+VNAG +P D+GP+I+P+AK RV +LI+SG +EGA +LLDGR +KV G
Sbjct 335 LPELVERAKKLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKG 394
Query 362 YENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQ 421
YENGNFVG TI + V +M YKEEIFGPVL ++ DTL++AI ++N NP+GNG +FT
Sbjct 395 YENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTT 454
Query 422 SGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
+GA AR + + +D+GQVG+N+PIPVP+P FSFTGSR S GD YGKQ +QFYTQ KTI
Sbjct 455 NGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTI 514
Query 482 TSRWFED 488
TS+W E+
Sbjct 515 TSQWKEE 521
>Q9EQ20 Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase
[acylating], mitochondrial [Mus musculus]
Length=535
Score = 617 bits (1592), Expect = 0.0
Identities = 289/487 (59%), Positives = 380/487 (78%), Gaps = 0/487 (0%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
S+ + T KLFIDGKF++SK+ +W DI NPAT EV+GRVP +T E+D A+ + K+AF
Sbjct 33 SSSSVPTVKLFIDGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMDAAVESCKRAFPA 92
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W T I +R +++L+ Q LI+ N+KEIA ++T EQGKTLADAEGD+ RGL+VVEHACSV
Sbjct 93 WADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVT 152
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
+L +GE + + + +D Y+ + PLGVCAGI PFNFPAMIPLWMFPMA+VCGNTF++KPSE
Sbjct 153 SLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSE 212
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ P +TM+L +L ++G P G LN++HG + V+ +C H DIKAISFVGS G +++
Sbjct 213 RVPGATMLLAKLLQDSGAPDGTLNIIHGQHDAVNFICDHPDIKAISFVGSNQAGEYIFER 272
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNW 301
++GKRVQ+ MGAKNH VVMPDA++E TLN LVGAAFGAAGQRCMALS A++VGE K W
Sbjct 273 GSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKW 332
Query 302 VNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNG 361
+ +LV++AK L+VNAG +P D+GP+I+P+AK RV +LI+SG +EGA +LLDGR +KV G
Sbjct 333 LPELVDRAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRRIKVKG 392
Query 362 YENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQ 421
YENGNFVG TI + V SM YKEEIFGPVL ++ +TL++AI ++N NP+GNG +FT
Sbjct 393 YENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTT 452
Query 422 SGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
+GA AR + + +D+GQVG+N+PIPVP+P FSFTGSR S GD YGKQ +QFYTQ KTI
Sbjct 453 NGATARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
Query 482 TSRWFED 488
TS+W E+
Sbjct 513 TSQWKEE 519
>Q7QC84 Probable methylmalonate-semialdehyde/malonate-semialdehyde
dehydrogenase [acylating], mitochondrial [Anopheles gambiae]
Length=521
Score = 615 bits (1586), Expect = 0.0
Identities = 289/486 (59%), Positives = 378/486 (78%), Gaps = 0/486 (0%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
S + T K+FIDGKF++SKT +W D+ +PAT EV+ RVP T +E+ A+ ++K+A+KT
Sbjct 20 STASVPTTKMFIDGKFVESKTNDWIDLHDPATNEVVTRVPKCTQDEMQTAVESSKKAYKT 79
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W + I +R ++MLKLQ +IR NM E+A +T EQGKTL DAEGD+ RGL+VVEH CS+
Sbjct 80 WRQSSILSRQQVMLKLQHIIRNNMSELAKNITKEQGKTLIDAEGDVLRGLQVVEHCCSIT 139
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
+LQMGE + +A+ +DTY+ PLGV AGI PFNFPAMIPLWMFP+AI CGNT ++KPSE
Sbjct 140 SLQMGETVPNIAKDMDTYSYHLPLGVTAGIAPFNFPAMIPLWMFPVAITCGNTSIIKPSE 199
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ P +TM+L+E+ EAG P GV+NV+HG + V+ +C + DI+A+SFVGS G ++Y
Sbjct 200 RVPGATMLLMEMLNEAGCPPGVVNVIHGAHDAVNFVCDNPDIRAVSFVGSDQAGKYIYER 259
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNW 301
AG++GKRVQ MGAKNH V+M DA++E TLN L GAAFGAAGQRCMALS AV VGE +NW
Sbjct 260 AGRNGKRVQCNMGAKNHGVIMADANKENTLNQLAGAAFGAAGQRCMALSTAVFVGEARNW 319
Query 302 VNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNG 361
+ LVE+A+ LKVNAGH P TD+GPVISP++K R+ +L+ SG +EGA+++LDGR++KV G
Sbjct 320 IPDLVERARKLKVNAGHLPGTDLGPVISPQSKQRINELVESGAKEGAKIVLDGRNIKVEG 379
Query 362 YENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQ 421
+E GNFVG TI + V+ +M+ Y EEIFGPVL + VDT+++AI LIN NP+GNG +FT
Sbjct 380 FEKGNFVGPTIISDVTPNMKCYTEEIFGPVLVCLSVDTIDEAIELINNNPYGNGTAIFTT 439
Query 422 SGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
+GA AR F N ID+GQVG+N+PIPVP+P FSFTGSRGS LGD YGKQ ++FYTQTKT+
Sbjct 440 NGATARKFVNDIDVGQVGVNVPIPVPLPMFSFTGSRGSFLGDCHFYGKQGIKFYTQTKTV 499
Query 482 TSRWFE 487
T W E
Sbjct 500 TQLWRE 505
>Q0WM29 Methylmalonate-semialdehyde dehydrogenase [acylating],
mitochondrial [Arabidopsis thaliana]
Length=607
Score = 598 bits (1542), Expect = 0.0
Identities = 282/473 (60%), Positives = 363/473 (77%), Gaps = 0/473 (0%)
Query 13 IDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPIQARMR 72
I G F++S+++ + D++NPATQEV+ +VP+ T EE A++AAKQAF W TPI R R
Sbjct 118 IGGSFVESQSSSFIDVINPATQEVVSKVPLTTNEEFKAAVSAAKQAFPLWRNTPITTRQR 177
Query 73 IMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGEYIEGV 132
+MLK Q+LIR NM ++A +T EQGKTL D+ GDI RGLEVVEHAC + TLQMGEY+ V
Sbjct 178 VMLKFQELIRKNMDKLAMNITTEQGKTLKDSHGDIFRGLEVVEHACGMATLQMGEYLPNV 237
Query 133 ARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMMLVE 192
+ GVDTY++++PLGVCAGI PFNFPAMIPLWMFP+A+ CGNTF+LKPSE+DP ++++L E
Sbjct 238 SNGVDTYSIREPLGVCAGICPFNFPAMIPLWMFPVAVTCGNTFILKPSEKDPGASVILAE 297
Query 193 LAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGKRVQSM 252
LA EAG+P GVLN+VHG + V+ +C +DI+A+SFVGS G H+Y A GKR+QS
Sbjct 298 LAMEAGLPDGVLNIVHGTNDTVNAICDDEDIRAVSFVGSNTAGMHIYARAAAKGKRIQSN 357
Query 253 MGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVEKAKTL 312
MGAKNH +V+PDA+ + TLNAL+ A FGAAGQRCMALS V VG+ K+W ++LVE+AK L
Sbjct 358 MGAKNHGLVLPDANIDATLNALLAAGFGAAGQRCMALSTVVFVGDAKSWEDKLVERAKAL 417
Query 313 KVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNFVGATI 372
KV G EP D+GPVIS +AK R+ LI SGV +GA+LLLDGRD+ V GYE GNF+G TI
Sbjct 418 KVTCGSEPDADLGPVISKQAKERICRLIQSGVDDGAKLLLDGRDIVVPGYEKGNFIGPTI 477
Query 373 FNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVARTFQNA 432
+ V+ M YKEEIFGPVL + ++ ++AI++IN N +GNG +FT SGA AR FQ
Sbjct 478 LSGVTPDMECYKEEIFGPVLVCMQANSFDEAISIINKNKYGNGAAIFTSSGAAARKFQMD 537
Query 433 IDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRW 485
I+ GQ+GIN+PIPVP+PFFSFTG++ S GDL YGK V F+TQ KT+T +W
Sbjct 538 IEAGQIGINVPIPVPLPFFSFTGNKASFAGDLNFYGKAGVDFFTQIKTVTQQW 590
>Q54I10 Probable methylmalonate-semialdehyde/malonate-semialdehyde
dehydrogenase [acylating], mitochondrial [Dictyostelium
discoideum]
Length=528
Score = 598 bits (1542), Expect = 0.0
Identities = 292/487 (60%), Positives = 370/487 (76%), Gaps = 1/487 (0%)
Query 8 TAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPI 67
T KLFI+GKF++SKT EW ++ NPATQE++ +VP++T EE++ A+ AA AF W T +
Sbjct 29 TTKLFINGKFVESKTKEWLEVRNPATQELVTKVPVSTKEEMEAAVKAASDAFPAWRDTSV 88
Query 68 QARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGE 127
R RI+ ++LI NM +IA ++T EQGKTL DA+GD+ RGLEVVEH+ +V +L MGE
Sbjct 89 SNRSRIISNYKNLINKNMDKIAAIITEEQGKTLPDAKGDVFRGLEVVEHSVNVASLMMGE 148
Query 128 YIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLST 187
+E V++ VD Y+ QPLGVCAGITPFNFPAMIPLWMFP+AI CGNTFVLKPSE+ P ++
Sbjct 149 TVENVSKNVDIYSYVQPLGVCAGITPFNFPAMIPLWMFPLAIACGNTFVLKPSERVPSAS 208
Query 188 MMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGK 247
M LV+LA EAGVP GV+NV+HGGKE V+ +C +++AISFVG+ G H++ +GK
Sbjct 209 MFLVQLAQEAGVPDGVVNVIHGGKEAVNFICDAPEVRAISFVGADQAGRHIHARGTANGK 268
Query 248 RVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVE 307
RVQS M AKNH ++PDAH+E+TL+AL GAAFGA+GQRCMALS AV VGE+KNW+ +L E
Sbjct 269 RVQSNMAAKNHATIVPDAHKERTLDALTGAAFGASGQRCMALSAAVFVGESKNWIPELAE 328
Query 308 KAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVN-GYENGN 366
+AK LKV G P D+GPVIS +K R+ +LI SG+ EGA+ +LDGR+V V+ + GN
Sbjct 329 RAKKLKVAGGAAPGADLGPVISAASKQRIHELIQSGIDEGAKCILDGRNVVVDPEFSKGN 388
Query 367 FVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVA 426
FVG TI V MR YKEEIFGPVL ++VDT++ AI LINANP+GNG +FT SGAVA
Sbjct 389 FVGPTILTDVKPHMRCYKEEIFGPVLVCLNVDTVDQAIQLINANPYGNGTAVFTSSGAVA 448
Query 427 RTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRWF 486
R +Q ID+GQVGIN+PIPVP+PFFSFTGSRGS +G YGK VQF+TQ KTITS W
Sbjct 449 RKYQREIDVGQVGINLPIPVPLPFFSFTGSRGSFVGAGHFYGKTGVQFFTQIKTITSNWR 508
Query 487 EDTQEKG 493
+D G
Sbjct 509 DDDISHG 515
>Q7KW39 Probable methylmalonate-semialdehyde/malonate-semialdehyde
dehydrogenase [acylating], mitochondrial [Drosophila melanogaster]
Length=520
Score = 597 bits (1538), Expect = 0.0
Identities = 289/478 (60%), Positives = 367/478 (77%), Gaps = 0/478 (0%)
Query 8 TAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPI 67
T KLFIDGKF++SKT EW D+ +PAT +V+ RVP AT E+ A+ + K+AF++W I
Sbjct 25 TTKLFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFRSWSNQSI 84
Query 68 QARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGE 127
R ++M KLQ LI+ NM E+A +T EQGKTLADAEGD+ RGL+VVEH CS+ +LQMGE
Sbjct 85 LTRQQVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGE 144
Query 128 YIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLST 187
+ VAR +DTY+L PLGV AG+ PFNFPAMIPLWMFP+AI GNT +LKPSE+ P +T
Sbjct 145 TVANVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGAT 204
Query 188 MMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGK 247
M+L+EL EAG P GV+NV+HG + V+ +C +IKA+SFVGS G ++Y AG++GK
Sbjct 205 MLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFVGSDQAGKYIYERAGKNGK 264
Query 248 RVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVE 307
RVQS MGAKNH +++ DA++E TLN L GAAFGAAGQRCMALS AV VG+ + W+ LVE
Sbjct 265 RVQSNMGAKNHGIILGDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQAWIPDLVE 324
Query 308 KAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNF 367
+A+ LKVNAGH P TD+GPVIS ++ R+ DLI SGV+EGA+L+LDGR + V GYE+G F
Sbjct 325 RAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYF 384
Query 368 VGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVAR 427
VG TI + V+ SM+ Y EEIFGPVL I+ DTL+DAI ++NANP+GNG +FT +GA AR
Sbjct 385 VGPTILSDVTPSMKCYTEEIFGPVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAAR 444
Query 428 TFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRW 485
F N ID GQVG+N+PIPVP+P FSFTG+RGS GD YGKQ ++FYTQTKT+T W
Sbjct 445 KFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLW 502
>Q29HB2 Probable methylmalonate-semialdehyde/malonate-semialdehyde
dehydrogenase [acylating], mitochondrial [Drosophila pseudoobscura
pseudoobscura]
Length=520
Score = 594 bits (1532), Expect = 0.0
Identities = 290/480 (60%), Positives = 366/480 (76%), Gaps = 0/480 (0%)
Query 8 TAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPI 67
T KLFIDGKF++SKT EW D+ +PAT +V+ RVP AT +E+ A+ + K+AF++W I
Sbjct 25 TTKLFIDGKFVESKTKEWIDVHDPATNKVVTRVPKATQDEMQTALESNKKAFRSWSNQSI 84
Query 68 QARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGE 127
R +M KLQ LI+ NM E+A +T EQGKTLADAEGD+ RGL+VVEH CS+ +LQMGE
Sbjct 85 LTRQAVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGE 144
Query 128 YIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLST 187
+ VAR +DTY+L PLGV AGI PFNFPAMIPLWMFP+AI GNT +LKPSE+ P +T
Sbjct 145 TVANVARDMDTYSLVMPLGVTAGIAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGAT 204
Query 188 MMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGK 247
M+L+EL EAG P GV+NV+HG + V+ +C IKA+SFVGS G ++Y AG++GK
Sbjct 205 MLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPAIKAVSFVGSDQAGKYIYERAGKNGK 264
Query 248 RVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVE 307
RVQS MGAKNH V++ DA++E TLN L GAAFGAAGQRCMALS AV VG+ + W+ LVE
Sbjct 265 RVQSNMGAKNHGVILSDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQGWIPDLVE 324
Query 308 KAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNF 367
+A+ LKVNAGH P TD+GPVIS ++ R+ DLI SGV+EGA+L+LDGR + V G+E+G F
Sbjct 325 RAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKISVPGFEDGYF 384
Query 368 VGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVAR 427
VG TI + V+ SM+ Y EEIFGPVL I+ D L+DAI ++NANP+GNG +FT +GA AR
Sbjct 385 VGPTILSDVTPSMKCYTEEIFGPVLVILKADNLDDAIDIVNANPYGNGTAVFTTNGAAAR 444
Query 428 TFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRWFE 487
F N ID GQVG+N+PIPVP+P FSFTG+RGS GD YGKQ ++FYTQTKT+T W E
Sbjct 445 KFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRE 504
>P28810 Methylmalonate-semialdehyde dehydrogenase [acylating]
[Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP
104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)]
Length=497
Score = 560 bits (1443), Expect = 0.0
Identities = 270/490 (55%), Positives = 356/490 (73%), Gaps = 1/490 (0%)
Query 13 IDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPIQARMR 72
I G F++ + + NP L + A+ E+V+ A+A+A++ F +W TP+ R R
Sbjct 9 IAGAFVEGLGAQRIPVSNPLDNSTLAEIACASAEQVEQAVASARETFASWKETPVSERAR 68
Query 73 IMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGEYIEGV 132
+ML+ Q L++ + E+A ++++E GKT DA+GD+ RG+EVVEHAC+V +L MGE +E V
Sbjct 69 VMLRYQALLKEHHDELAKIVSSELGKTFEDAKGDVWRGIEVVEHACNVPSLLMGETVENV 128
Query 133 ARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMMLVE 192
AR +DTY++ QPLGVC GITPFNFPAMIPLWMFP+AI CGN F+LKPSEQ PL+++ L E
Sbjct 129 ARNIDTYSITQPLGVCVGITPFNFPAMIPLWMFPLAIACGNAFILKPSEQVPLTSVRLAE 188
Query 193 LAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGKRVQSM 252
L EAG P GVL VVHGGKE VD+L H +KA+SFVGS AVG +VY+ H KRVQS
Sbjct 189 LFLEAGAPKGVLQVVHGGKEQVDQLLKHPQVKAVSFVGSVAVGQYVYHTGTAHNKRVQSF 248
Query 253 MGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGETKNWVNQLVEKAKTL 312
GAKNH+V+MPDA + Q ++ LVGA+ GAAGQRCMA+SVAV+VG + W+ ++ + +
Sbjct 249 AGAKNHMVIMPDADKAQVISNLVGASVGAAGQRCMAISVAVLVGAAREWIPEIRDALAKV 308
Query 313 KVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNFVGATI 372
+ + GPVI+P+AKAR+ LI GV+EGA+LLLDGR KV GY +GN+VG T+
Sbjct 309 RPGPWDDSGASYGPVINPQAKARIERLIGQGVEEGAQLLLDGRGYKVEGYPDGNWVGPTL 368
Query 373 FNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVARTFQNA 432
F V M IY+EE+FGPVL + VD+LE AI LIN +P+GNG +FT SGA ARTFQ+
Sbjct 369 FAGVRPDMAIYREEVFGPVLCLAEVDSLEQAIRLINESPYGNGTSIFTSSGAAARTFQHH 428
Query 433 IDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRWFEDTQEK 492
I++GQVGINIPIPVP+PFFSFTG +GS GDL YGKQ V+FYT+TKT+T+RWF+
Sbjct 429 IEVGQVGINIPIPVPLPFFSFTGWKGSFYGDLHAYGKQGVRFYTETKTVTARWFDSDSVA 488
Query 493 GEVNTTISLR 502
G N +I +R
Sbjct 489 G-TNFSIQMR 497
>Q9I702 Malonate-semialdehyde dehydrogenase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=497
Score = 469 bits (1208), Expect = 1e-165
Identities = 227/461 (49%), Positives = 325/461 (70%), Gaps = 2/461 (0%)
Query 27 DILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPIQARMRIMLKLQDLIRTNMK 86
D+ NP+T E + +VP+A + + AI AA+ AF W TP R +++ + + L+ N
Sbjct 21 DVFNPSTGEAIHKVPLADGKTLQKAIDAARAAFPAWRNTPPAKRAQVLYRFKQLLEQNEA 80
Query 87 EIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGEYIEGVARGVDTYTLQQPLG 146
I+ +++ E GKTL DA G+++RG+E VE+AC+ + GEY V +D ++ QP+G
Sbjct 81 RISKLISEEHGKTLEDAAGELKRGIENVEYACAAPEILKGEYSRNVGPNIDAWSDFQPIG 140
Query 147 VCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMMLVELAAEAGVPAGVLNV 206
V AGITPFNFPAM+PLWM+P+AI CGNTF+LKPSE+DP ST+++ EL EAG+P GVLNV
Sbjct 141 VVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNV 200
Query 207 VHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQHGKRVQSMMGAKNHVVVMPDAH 266
VHG KE VD L ++KAISFVGST + ++Y + GKRVQ++ GAKNH V+MPDA
Sbjct 201 VHGDKEAVDGLLQAPEVKAISFVGSTPIAEYIYAEGTKRGKRVQALGGAKNHAVLMPDAD 260
Query 267 QEQTLNALVGAAFGAAGQRCMALSVAVMVGE--TKNWVNQLVEKAKTLKVNAGHEPQTDI 324
+ ++AL+GAA+G+ G+RCMA+SVAV VG+ + +LV + K LK+ AG D+
Sbjct 261 LDNAVSALMGAAYGSCGERCMAISVAVCVGDQVADALIAKLVPQIKALKIGAGTSCGLDM 320
Query 325 GPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNFVGATIFNQVSTSMRIYK 384
GP+++ A+A+V I+SGV +GAEL++DGR +V G+ENG F+G ++F++V+ M IYK
Sbjct 321 GPLVTAAAQAKVTGYIDSGVAQGAELVVDGRGYQVAGHENGFFLGGSLFDRVTPEMTIYK 380
Query 385 EEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVARTFQNAIDIGQVGINIPI 444
EEIFGPVL ++ V++LE+A+ LIN + +GNG +FT+ G AR F + I++G VG+N+P+
Sbjct 381 EEIFGPVLCVVRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVNVPL 440
Query 445 PVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRW 485
PVPV + SF G + S GDL YG V+FYT+ K IT RW
Sbjct 441 PVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTRRKAITQRW 481
>A7BJC4 Malonate-semialdehyde dehydrogenase [Bacillus subtilis
subsp. natto]
Length=487
Score = 430 bits (1105), Expect = 3e-150
Identities = 217/481 (45%), Positives = 315/481 (65%), Gaps = 4/481 (1%)
Query 6 LKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLT 65
++ K +I+G++++SKT +++D++NPAT+EVL +VP++T E++D A A +AF+TW
Sbjct 4 IRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFETWSKV 63
Query 66 PIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQM 125
+ R RI+ Q L+ + +E+A ++T E GK +A G++ RG+E VE A +L M
Sbjct 64 AVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMM 123
Query 126 GEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPL 185
G+ + +A V+ + P+GV GI PFNFP M+P WMFPMAI GNTF+LKPSE+ PL
Sbjct 124 GDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPL 183
Query 186 STMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQH 245
T LVEL +AG+P GV NVV+G +VV+ + H +IKAISFVGS VG +VY +H
Sbjct 184 LTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSEH 243
Query 246 GKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALS-VAVMVGETKNWVNQ 304
KRVQS+ GAKNH +V+ DA+ E T+ +VGAAFG+AG+RCMA + V V G ++ +
Sbjct 244 LKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAK 303
Query 305 LVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYEN 364
L EK +K+ G + +GPVI K R + I G++EGA L+ DGR+ N ++
Sbjct 304 LQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRE---NVSDD 360
Query 365 GNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGA 424
G FVG TIF+ V+T M I+K+EIF PVL++I V L++AI + N + F NG LFT +
Sbjct 361 GYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSN 420
Query 425 VARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSR 484
R F+ ID G +GIN+ +P P+ FF F+G + S G L GK +V FYT+ K +T+R
Sbjct 421 AIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTAR 480
Query 485 W 485
+
Sbjct 481 F 481
>P42412 Malonate-semialdehyde dehydrogenase [Bacillus subtilis
(strain 168)]
Length=487
Score = 429 bits (1103), Expect = 5e-150
Identities = 217/481 (45%), Positives = 315/481 (65%), Gaps = 4/481 (1%)
Query 6 LKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLT 65
++ K +I+G++++SKT +++D++NPAT+EVL +VP++T E++D A A +AFKTW
Sbjct 4 IRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWSKV 63
Query 66 PIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQM 125
+ R RI+ Q L+ + +E+A ++T E GK +A G++ RG+E VE A +L M
Sbjct 64 AVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMM 123
Query 126 GEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPL 185
G+ + +A V+ + P+GV GI PFNFP M+P WMFPMAI GNTF+LKPSE+ PL
Sbjct 124 GDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPL 183
Query 186 STMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNLAGQH 245
T LVEL +AG+P GV NVV+G +VV+ + H +IKAISFVGS VG +VY ++
Sbjct 184 LTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSEN 243
Query 246 GKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALS-VAVMVGETKNWVNQ 304
KRVQS+ GAKNH +V+ DA+ E T+ +VGAAFG+AG+RCMA + V V G ++ +
Sbjct 244 LKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAK 303
Query 305 LVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYEN 364
L EK +K+ G + +GPVI K R + I G++EGA L+ DGR+ N ++
Sbjct 304 LQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRE---NVSDD 360
Query 365 GNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGA 424
G FVG TIF+ V+T M I+K+EIF PVL++I V L++AI + N + F NG LFT +
Sbjct 361 GYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSN 420
Query 425 VARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSR 484
R F+ ID G +GIN+ +P P+ FF F+G + S G L GK +V FYT+ K +T+R
Sbjct 421 AIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTAR 480
Query 485 W 485
+
Sbjct 481 Y 481
>A5YBJ3 Malonate-semialdehyde dehydrogenase [Lacticaseibacillus
casei]
Length=492
Score = 422 bits (1086), Expect = 2e-147
Identities = 215/485 (44%), Positives = 310/485 (64%), Gaps = 3/485 (1%)
Query 2 SNMHLKTAKLFIDGKFIDSKTTEWQDILNPATQEVLGRVPMATLEEVDVAIAAAKQAFKT 61
+ ++KT K FI+GK++D+KT ++++ NPAT +VL RVP +T E+V A+ AAK+AFK
Sbjct 4 TKQNVKTLKNFINGKWVDAKTETFENVYNPATGDVLARVPHSTSEDVADAVTAAKEAFKI 63
Query 62 WHLTPIQARMRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVG 121
W I R +I+ K Q L+ + +E+ ++T E GK+L +A ++ RG+E VE A V
Sbjct 64 WQKVSIPKRAKILFKYQQLLVEHQEELGRIVTEENGKSLDEAVAEVGRGIENVEFAAGVP 123
Query 122 TLQMGEYIEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSE 181
TL MG+ + VA V+ + P+GV GITPFNFP M+P WMFPMA+ GNTF+LKPSE
Sbjct 124 TLMMGDSLSSVATDVEATNYRYPIGVVGGITPFNFPMMVPCWMFPMAVATGNTFILKPSE 183
Query 182 QDPLSTMMLVELAAEAGVPAGVLNVVHGGKEVVDRLCTHQDIKAISFVGSTAVGTHVYNL 241
+ PL++ LVEL EAG+P GVLN+V+G +VV+ + H DIKAISFVGS VG +VY
Sbjct 184 KTPLTSQRLVELFQEAGLPDGVLNIVNGAVDVVNGILDHPDIKAISFVGSERVGEYVYKR 243
Query 242 AGQHGKRVQSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALSVAVMVGE-TKN 300
H KRVQ++ GAKNH +V+ DA + + ++ ++FG+AG+RCMA SV V+ E
Sbjct 244 GSDHLKRVQALTGAKNHTIVLADADLDAAVKGIISSSFGSAGERCMATSVLVLQDEIADK 303
Query 301 WVNQLVEKAKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVN 360
++ + + AK +K+ G + +GPVI + R ++ I +GV+EGA+L+LDG
Sbjct 304 FMAKFTQAAKDIKIGNGLDKGVFLGPVIRKENQERTLNYIQTGVKEGAKLVLDGSAEAKK 363
Query 361 GYENGNFVGATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFT 420
+G FVG TIF V T M I+ +E+F PVL++I L A+A+ N + NG LFT
Sbjct 364 --HDGYFVGPTIFEDVKTDMTIWHDEMFAPVLSVIRAKDLPQAVAIANTSELANGACLFT 421
Query 421 QSGAVARTFQNAIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKT 480
S A R F+ ID G +GIN+ +P P+ F F+G + S G L GK +V FYT K
Sbjct 422 DSAASIRYFRENIDAGMLGINLGVPAPIAVFPFSGWKHSFFGTLHANGKDSVDFYTHKKV 481
Query 481 ITSRW 485
+T+R+
Sbjct 482 VTARY 486
>P42236 Alpha-ketoglutaric semialdehyde dehydrogenase [Bacillus
subtilis (strain 168)]
Length=488
Score = 267 bits (683), Expect = 5e-87
Identities = 157/476 (33%), Positives = 254/476 (53%), Gaps = 10/476 (2%)
Query 12 FIDGKFIDSKTTEWQDILNPA-TQEVLGRVPMATLEEVDVAIAAAKQAFKTWHLTPIQAR 70
FI+G+++ S++ + + NPA +++G V +T E+V+ A+ AA +A W R
Sbjct 13 FINGEWVKSQSGDMVKVENPADVNDIVGYVQNSTAEDVERAVTAANEAKTAWRKLTGAER 72
Query 71 MRIMLKLQDLIRTNMKEIAGVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGEYIE 130
+ + K D++ ++EIA T E GKTL +A+G+ RG+ ++ + G + G+ I
Sbjct 73 GQYLYKTADIMEQRLEEIAACATREMGKTLPEAKGETARGIAILRYYAGEGMRKTGDVIP 132
Query 131 GVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMML 190
+ +T + PLGV I+P+NFP IP+W A+V GNT V+KP+ + ++ +
Sbjct 133 STDKDALMFTTRVPLGVVGVISPWNFPVAIPIWKMAPALVYGNTVVIKPATETAVTCAKI 192
Query 191 VELAAEAGVPAGVLNVVHGGKEVVDR-LCTHQDIKAISFVGSTAVGTHVYNLAGQHGKRV 249
+ EAG+PAGV+N+V G VV + L H + A++F GS VG + A G +
Sbjct 193 IACFEEAGLPAGVINLVTGPGSVVGQGLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKY 252
Query 250 QSMMGAKNHVVVMPDAHQEQTLNALVGAAFGAAGQRCMALS-VAVMVGETKNWVNQLVEK 308
Q MG KN V+V DA E A++ AF + GQ+C A S V V G + + +L+++
Sbjct 253 QLEMGGKNPVIVADDADLEAAAEAVITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQR 312
Query 309 AKTLKVNAGHEPQTDIGPVISPRAKARVIDLINSGVQEGAELLLDGRDVKVNGYENGNFV 368
K + + + +GP+ S + I G QEGA LL+ G ++ Y+NG +V
Sbjct 313 TKDITIGDSLKEDVWMGPIASKNQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYV 372
Query 369 GATIFNQVSTSMRIYKEEIFGPVLAIIHVDTLEDAIALINANPFGNGVGLFTQSGAVART 428
IF+ V++ M I +EEIFGPV+A+I VD++E+A+ + N FG +FT++ +
Sbjct 373 QPAIFDNVTSEMTIAQEEIFGPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLS 432
Query 429 FQNAIDIGQVGINIP---IPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTI 481
F + ID G V IN + + PF G G+ A F+T KT+
Sbjct 433 FIDEIDAGLVRINAESAGVELQAPF----GGMKQSSSHSREQGEAAKDFFTAIKTV 484
Lambda K H a alpha
0.320 0.135 0.396 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3341907
Database: 2c5c1298618d1b11edc738bf8a34a572.SwissProt.fasta
Posted date: May 18, 2024 4:45 PM
Number of letters in database: 8,307
Number of sequences in database: 16
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
Loading
Data ...
