BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 816c63130a01934fb04ccbea3a9ffb01.SwissProt.fasta
16 sequences; 5,052 total letters
Query= ACIAD1605
Length=298
Score E
Sequences producing significant alignments: (Bits) Value
Q54CX6 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial... 298 4e-104
P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo sa... 271 1e-93
Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Mus mus... 271 2e-93
Q5R5E7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Pongo a... 270 6e-93
Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Bos tau... 269 1e-92
P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Rattus ... 268 2e-92
Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aerugino... 266 3e-92
P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa... 256 5e-88
Q9XTI0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial... 252 2e-86
Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial... 241 6e-82
Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium bark... 208 2e-69
P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str... 170 1e-54
P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str... 147 1e-45
P0A9V8 3-sulfolactaldehyde reductase [Escherichia coli (strain K12)] 142 1e-43
O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigi... 140 3e-43
F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplasti... 133 9e-40
>Q54CX6 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
[Dictyostelium discoideum]
Length=321
Score = 298 bits (762), Expect = 4e-104
Identities = 144/293 (49%), Positives = 201/293 (69%), Gaps = 1/293 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIGLGNMGG NL+K G + FD+S+ + E G ++SP + AK AD+++T
Sbjct 25 VGFIGLGNMGGHQAINLIKKGHNLIVFDMSKDNMNRLKEKGAKIANSPAEVAKEADVIVT 84
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLPA+ HVK +Y E+G+F ++ G++ +DSSTIDP + +++A I + + D PVSG
Sbjct 85 MLPASAHVKNVYCGENGIFQTVRPGTLLLDSSTIDPATAREVASIAKKHQSTMLDCPVSG 144
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
GT GA+AGTLTFMVG F K+ L MGKNIV+CG+VG+GQ+AK+CNNL+LGISM
Sbjct 145 GTGGAEAGTLTFMVGGSEQDFNTAKTYLECMGKNIVHCGDVGTGQVAKVCNNLVLGISMI 204
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AV+E M LG K G+DP+ LAG+ N+SS RCW+SE+ NP P V +PA RGY+ GF + L
Sbjct 205 AVSEAMNLGVKQGMDPKKLAGIFNTSSARCWTSELYNPCPGVIETSPASRGYTGGFGSAL 264
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQN 295
M KDLGLA+++A + +P+LL Q Y L +G+ Q DF S++ +L +N
Sbjct 265 MTKDLGLAVDSAKSIGEPLLLGNSAHQLYTLLVAKGDGQKDF-SVVYDFLNKN 316
>P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo
sapiens]
Length=336
Score = 271 bits (694), Expect = 1e-93
Identities = 138/287 (48%), Positives = 182/287 (63%), Gaps = 0/287 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIGLGNMG M +NL+K G + +D+ A F +AG SP D A+ AD +IT
Sbjct 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLP + + E Y +G+ +K+GS+ IDSSTIDP K++AK + G DAPVSG
Sbjct 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSG 161
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
G A++G LTFMVG D F + +L MG N+VYCG VG+GQ AKICNN++L ISM
Sbjct 162 GVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMI 221
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE M LG +LG+DP++LA ++N SSGRCWSS+ NP P V P+ Y GF T L
Sbjct 222 GTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTL 281
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
M KDLGLA ++A K P+LL L Q Y+ +C +G ++ DFSS+ Q
Sbjct 282 MAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQ 328
>Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Mus
musculus]
Length=335
Score = 271 bits (693), Expect = 2e-93
Identities = 136/287 (47%), Positives = 183/287 (64%), Gaps = 0/287 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIGLGNMG M +NL+K G + +D+ F EAG + SP + A+ AD +IT
Sbjct 41 VGFIGLGNMGNPMAKNLMKHGYPLILYDVFPDVCKEFKEAGEQVASSPAEVAEKADRIIT 100
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLP++ + E+Y +G+ +K+GS+ IDSSTIDP K++AK + G DAPVSG
Sbjct 101 MLPSSMNAVEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSG 160
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
G A++G LTFMVG D F + +L MG N+VYCG VG+GQ AKICNN++L ISM
Sbjct 161 GVGAARSGNLTFMVGGVEDEFAAAQELLECMGSNVVYCGAVGTGQSAKICNNMLLAISMI 220
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE M LG + G+DP++LA ++N SSGRCWSS+ NP P V P+ Y GF T L
Sbjct 221 GTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMHGVPSSNNYQGGFGTTL 280
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
M KDLGLA ++A K P+LL L Q Y+ +C +G ++ DFSS+ Q
Sbjct 281 MAKDLGLAQDSATSTKTPILLGSLAHQIYRMMCSKGYSKKDFSSVFQ 327
>Q5R5E7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Pongo
abelii]
Length=336
Score = 270 bits (689), Expect = 6e-93
Identities = 137/287 (48%), Positives = 181/287 (63%), Gaps = 0/287 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIGLGNMG M +NL+K G + +D+ A F +AG SP D A+ AD +IT
Sbjct 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLP + + E Y +G+ +K+GS+ IDSSTIDP K++AK + G DAPVSG
Sbjct 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSG 161
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
G A++G LTFMVG D F + +L MG N+VYCG VG+GQ AKICNN++L ISM
Sbjct 162 GVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMI 221
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE M LG +LG+DP++LA ++N SSGRCWSS+ NP P V P+ Y GF L
Sbjct 222 GTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGATL 281
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
M KDLGLA ++A K P+LL L Q Y+ +C +G ++ DFSS+ Q
Sbjct 282 MAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQ 328
>Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Bos
taurus]
Length=336
Score = 269 bits (687), Expect = 1e-92
Identities = 136/287 (47%), Positives = 182/287 (63%), Gaps = 0/287 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIG+GNMG M +NL+K G + +D+ A F++AG SP D A+ AD +IT
Sbjct 42 VGFIGVGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFLDAGEQVVSSPADVAEKADRIIT 101
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLP + + E Y +G+ +K+GS+ IDSSTIDP K++AK + G DAPVSG
Sbjct 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPMVSKELAKEVEKMGAVFMDAPVSG 161
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
G A++G LTFMVG + F + +L MG N+VYCG VG+GQ AKICNNL+L ISM
Sbjct 162 GVGAARSGNLTFMVGGVEEEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNLLLAISMI 221
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE M LG +LG+DP++LA ++N SSGRCWSS+ NP P V P+ Y GF T L
Sbjct 222 GTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTL 281
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
M KDLGLA ++A K P+LL Q Y+ +C +G ++ DFSS+ Q
Sbjct 282 MAKDLGLAQDSATSTKSPILLGSQAHQIYRMMCAKGYSKKDFSSVFQ 328
>P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Rattus
norvegicus]
Length=335
Score = 268 bits (686), Expect = 2e-92
Identities = 135/287 (47%), Positives = 183/287 (64%), Gaps = 0/287 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
+ FIGLGNMG M +NL+K G + +D+ F EAG + SP D A+ AD +IT
Sbjct 41 VGFIGLGNMGNPMAKNLIKHGYPLILYDVFPDVCKEFKEAGEQVASSPADVAEKADRIIT 100
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLP++ + E+Y +G+ +K+GS+ IDSSTIDP K++AK + G DAPVSG
Sbjct 101 MLPSSMNSIEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSG 160
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
G A++G LTFMVG + F + +L MG N++YCG VGSGQ AKICNN++L ISM
Sbjct 161 GVGAARSGNLTFMVGGVENEFAAAQELLGCMGSNVLYCGAVGSGQSAKICNNMLLAISMI 220
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE M LG + G+DP++LA ++N SSGRCWSS+ NP P V P+ Y GF T L
Sbjct 221 GTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSSNNYQGGFGTTL 280
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
M KDLGLA ++A K P+LL + Q Y+ +C +G ++ DFSS+ Q
Sbjct 281 MAKDLGLAQDSATSTKTPILLGSVAHQIYRMMCSKGYSKKDFSSVFQ 327
>Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298
Score = 266 bits (681), Expect = 3e-92
Identities = 139/295 (47%), Positives = 187/295 (63%), Gaps = 0/295 (0%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
IAFIGLG+MG M NLLK G + FDL Q+A+ V AG A+ S DA + AD+VI+
Sbjct 4 IAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGASAARSARDAVQGADVVIS 63
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSG 122
MLPA++HV+ +YL +DG+ + G++ ++ STI P S + I E+G+ + DAPVSG
Sbjct 64 MLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAPVSG 123
Query 123 GTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMT 182
GT GA AGTLTFMVG DA+ E+ + + +MG+NI + G G+GQ+AK+CNN +L + M
Sbjct 124 GTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAVLMI 183
Query 183 AVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQL 242
AE MALG G++ ++LA ++ SSG W+ EV NPWP V NAPA R YS GF QL
Sbjct 184 GTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPWPGVMENAPASRDYSGGFMAQL 243
Query 243 MLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ 297
M KDLGLA EAA + L Y+ L QG A+ DFS + + + P Q
Sbjct 244 MAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQKLFDPTQGQ 298
>P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298
Score = 256 bits (653), Expect = 5e-88
Identities = 136/293 (46%), Positives = 188/293 (64%), Gaps = 4/293 (1%)
Query 2 NIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVI 61
+IAF+GLGNMGG M NLLK G V FDL A+ VE G +DS + A++VI
Sbjct 3 DIAFLGLGNMGGPMAANLLKAGHRVNVFDLQPKAVLGLVEQGAQGADSALQCCEGAEVVI 62
Query 62 TMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVS 121
+MLPA +HV+ +YL +DG+ + + ID STI P++ + +A+ A KG+ + DAPVS
Sbjct 63 SMLPAGQHVESLYLGDDGLLARVAGKPLLIDCSTIAPETARKVAEAAAAKGLTLLDAPVS 122
Query 122 GGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISM 181
GG GA+AGTL+F+VG A+ F + + VL +MG+NI + G+ G+GQ+AKICNN++LGI M
Sbjct 123 GGVGGARAGTLSFIVGGPAEGFARARPVLENMGRNIFHAGDHGAGQVAKICNNMLLGILM 182
Query 182 TAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQ 241
AE +ALG K G+DP +L+ V+ SSG W+ + NPWP V APA GY+ GF +
Sbjct 183 AGTAEALALGVKNGLDPAVLSEVMKQSSGGNWALNLYNPWPGVMPQAPASNGYAGGFQVR 242
Query 242 LMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQ---LDFSSIIQQY 291
LM KDLGLA+ A V+ L L + + L Q +A+ LDFSSI + Y
Sbjct 243 LMNKDLGLALANAQAVQASTPLGALARNLF-SLHAQADAEHEGLDFSSIQKLY 294
>Q9XTI0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
[Caenorhabditis elegans]
Length=299
Score = 252 bits (643), Expect = 2e-86
Identities = 135/294 (46%), Positives = 182/294 (62%), Gaps = 2/294 (1%)
Query 5 FIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVITML 64
FIGLGNMGG M +NL+K G + +D+++ + F G + P D A + +IT+L
Sbjct 6 FIGLGNMGGHMARNLIKNGKKLIVYDVNKAVVQEFKAEGCEVAAHPADIAAASKEIITVL 65
Query 65 PAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSGGT 124
P++ HVK +Y E G+F ++ G++C+DSSTID ++A+ A + DAP+SGG
Sbjct 66 PSSPHVKAVYQGEAGIFKTIQPGTLCMDSSTIDQIVSLEVAQAAALLKAEYIDAPISGGV 125
Query 125 IGAQAGTLTFMVGTDADL-FEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISMTA 183
GAQ TLTFMVG D F++ ++VLS MGKNIV G VG+G AKICNN++LGI M A
Sbjct 126 TGAQQATLTFMVGAGNDATFKRAEAVLSLMGKNIVNLGAVGNGTAAKICNNMLLGIQMVA 185
Query 184 VAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQLM 243
VAE M LG +G+D + LAG++N+SSGRCWSS+ NP P V N P+ RGY+ GF T LM
Sbjct 186 VAETMNLGISMGLDAKALAGIVNTSSGRCWSSDTYNPVPGVIENIPSCRGYAGGFGTTLM 245
Query 244 LKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQL-DFSSIIQQYLPQNS 296
KDL LA A+ + P + L Q Y+ L Q DF + Q QNS
Sbjct 246 AKDLSLAQNASTNTQAPTPMGSLAHQIYRILARDPQYQAKDFGVVYQFLKKQNS 299
>Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
[Drosophila melanogaster]
Length=324
Score = 241 bits (615), Expect = 6e-82
Identities = 131/288 (45%), Positives = 170/288 (59%), Gaps = 6/288 (2%)
Query 2 NIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVI 61
NI F+GLGNMG M NL+K G ++ FD+S+ A G + AKN+D VI
Sbjct 30 NIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYAKTSELAKNSDFVI 89
Query 62 TMLPAAKHVKEIY--LAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAP 119
TMLP V Y + DGV + +I IDSSTI P +K + K + KG + DAP
Sbjct 90 TMLPNNAIVDASYDEMTADGV----NKDTIFIDSSTISPDLVKSLQKKISAKGARFIDAP 145
Query 120 VSGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGI 179
VSGG GA+ TLTFMVG + VK+VL MGK I +CG G GQ AK+CNN++L I
Sbjct 146 VSGGVPGAEQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNMMLAI 205
Query 180 SMTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFA 239
SM V+E M L + G+D + A +INSS+GRCW+SE+ NP P V +APA R Y+ GF+
Sbjct 206 SMIGVSEAMNLAVRQGLDANVFAEIINSSTGRCWASEIYNPVPGVCPSAPANRDYAGGFS 265
Query 240 TQLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSI 287
+ L+ KDLGLA A P+ L L + YQ LC +G DFS +
Sbjct 266 SALITKDLGLASGVANASNSPIPLGSLAHKVYQSLCDKGLGNKDFSVV 313
Score = 17.3 bits (33), Expect = 7.2
Identities = 7/15 (47%), Positives = 10/15 (67%), Gaps = 0/15 (0%)
Query 7 GLGNMGGKMVQNLLK 21
GLGN +V +L+K
Sbjct 304 GLGNKDFSVVYDLMK 318
>Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium
barkeri]
Length=301
Score = 208 bits (530), Expect = 2e-69
Identities = 116/289 (40%), Positives = 169/289 (58%), Gaps = 6/289 (2%)
Query 1 MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV 60
+ I FIGLG MG M NLLK G TVY FDL + +A V G A ++ A +DI+
Sbjct 5 IKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQACENNQKVAAASDII 64
Query 61 ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV 120
T LP A V+ + GV + K G++ +D S++ P S +AK+ AEKGI DAPV
Sbjct 65 FTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPV 124
Query 121 SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS 180
SGGT GA+AGTLT MVG +FE+++ VLS +GK+I + G+ G+G KI NNL+LG +
Sbjct 125 SGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLLGCN 184
Query 181 MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT 240
M ++AE + LG K G+ P+ + +I SSGR ++ E +S + ++ GFA
Sbjct 185 MASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKFIMSGD------FAGGFAM 238
Query 241 QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
L KDLGLA+EA + P+ + + Q ++ G + D S++I+
Sbjct 239 DLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIK 287
>P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli
(strain K12)]
Length=294
Score = 170 bits (430), Expect = 1e-54
Identities = 98/291 (34%), Positives = 159/291 (55%), Gaps = 7/291 (2%)
Query 1 MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV 60
M + FIGLG MG M +NLLK G ++ D + AIA + AG + + A+ D++
Sbjct 1 MKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVI 60
Query 61 ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV 120
ITMLP + HVKE+ L E+G+ K G++ ID S+I P + ++I++ KGI + DAPV
Sbjct 61 ITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPV 120
Query 121 SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS 180
SGG A GTL+ MVG D +F++ ++ +M ++V+ GE+G+G + K+ N +I+ ++
Sbjct 121 SGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALN 180
Query 181 MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT 240
+ A++E + L K G++P ++ I G S+ + D A R + GF
Sbjct 181 IAAMSEALTLATKAGVNPDLVYQAIR--GGLAGSTVL-----DAKAPMVMDRNFKPGFRI 233
Query 241 QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQY 291
L +KDL A++ + V + L V + Q L G D S++ Y
Sbjct 234 DLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYY 284
>P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli
(strain K12)]
Length=292
Score = 147 bits (370), Expect = 1e-45
Identities = 92/289 (32%), Positives = 144/289 (50%), Gaps = 8/289 (3%)
Query 1 MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV 60
M + FIGLG MG M NL + G ++ + A + G ++ ++ + +DI+
Sbjct 1 MKLGFIGLGIMGTPMAINLARAGHQLHVTTIGPVA-DELLSLGAVSVETARQVTEASDII 59
Query 61 ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV 120
M+P V+E+ E+G +G +D S+I P K A+ E G DAPV
Sbjct 60 FIMVPDTPQVEEVLFGENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPV 119
Query 121 SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS 180
SGG IGA+ GTL+ MVG D +FE+VK + +GKNI G G GQ K+ N +I+ ++
Sbjct 120 SGGEIGAREGTLSIMVGGDEAVFERVKPLFELLGKNITLVGGNGDGQTCKVANQIIVALN 179
Query 181 MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT 240
+ AV+E + +K G DP V + G SS + +V R ++ GF
Sbjct 180 IEAVSEALLFASKAGADP---VRVRQALMGGFASSRIL----EVHGERMIKRTFNPGFKI 232
Query 241 QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
L KDL LA+++A + + Q+ + G +QLD S+++Q
Sbjct 233 ALHQKDLNLALQSAKALALNLPNTATCQELFNTCAANGGSQLDHSALVQ 281
>P0A9V8 3-sulfolactaldehyde reductase [Escherichia coli (strain
K12)]
Length=298
Score = 142 bits (357), Expect = 1e-43
Identities = 96/290 (33%), Positives = 146/290 (50%), Gaps = 10/290 (3%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVIT 62
IAFIGLG MG M NLL+ G + FD++ A+ H V+ G + +P AAK+A+ +IT
Sbjct 4 IAFIGLGQMGSPMASNLLQQGHQLRVFDVNAEAVRHLVDKGATPAANPAQAAKDAEFIIT 63
Query 63 MLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDP-QSIKDIAKIGAEKGIKVCDAPVS 121
MLP V+ + E+GV L ++ ID STI P Q+ K IA + A KG + D PV
Sbjct 64 MLPNGDLVRNVLFGENGVCEGLSTDALVIDMSTIHPLQTDKLIADMQA-KGFSMMDVPVG 122
Query 122 GGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISM 181
+ A GTL + G A+ E+ +L +MG ++ G G G K+ NN + I++
Sbjct 123 RTSANAITGTLLLLAGGTAEQVERATPILMAMGSELINAGGPGMGIRVKLINN-YMSIAL 181
Query 182 TAV-AEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT 240
A+ AE L L + + V++ ++ WP N S F
Sbjct 182 NALSAEAAVLCEALNLPFDVAVKVMSGTA--AGKGHFTTSWP----NKVLSGDLSPAFMI 235
Query 241 QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQ 290
L KDLG+A++ A Q+ P+ L ++ Y Q G + D+S+I++Q
Sbjct 236 DLAHKDLGIALDVANQLHVPMPLGAASREVYSQARAAGRGRQDWSAILEQ 285
>O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigidimarina
(strain NCIMB 400)]
Length=291
Score = 140 bits (353), Expect = 3e-43
Identities = 95/288 (33%), Positives = 150/288 (52%), Gaps = 10/288 (3%)
Query 3 IAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEA-GGIASDSPHDAAKNADIVI 61
+AFIGLG MG M +L+K G V ++ + +VE GG +D+P DAA+ DIV
Sbjct 4 VAFIGLGVMGFPMAGHLVKQGHDVTVYNRTGAKATQWVEQYGGKKADTPKDAAQGQDIVF 63
Query 62 TMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVS 121
T + ++++ L E G+ + G+I +D +T ++IA I DAPVS
Sbjct 64 TCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLDAPVS 123
Query 122 GGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGISM 181
GG GA+ G LT M+G D F+ VK V+S+ + G VG+GQ+ K+ N + + +
Sbjct 124 GGQAGAENGALTVMMGGDQAHFDTVKPVISAYSRCAELLGPVGAGQLTKMVNQICIAGVV 183
Query 182 TAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFATQ 241
+AEG+ G+D + VI+ + + W E N + + Y GFA
Sbjct 184 QGLAEGLHFAKSAGLDGLKVIEVISKGAAQSWQME--NRYKTMWQGQ-----YDFGFAID 236
Query 242 LMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQL-CMQGNAQLDFSSII 288
M KDLG+A++ A + + +A LV Q Y ++ M+GN + D SS++
Sbjct 237 WMRKDLGIALDEARRNGSHLPVAALVDQFYSEVQAMKGN-RWDTSSLL 283
>F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplastic
[Arabidopsis thaliana]
Length=358
Score = 133 bits (334), Expect = 9e-40
Identities = 84/289 (29%), Positives = 137/289 (47%), Gaps = 7/289 (2%)
Query 1 MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV 60
++I F+G+G MG M QNL+K G V ++ +++ V G SP + D+
Sbjct 67 VSIGFLGMGIMGSPMAQNLIKAGCDVTVWNRTKSKCDPLVGLGAKYKSSPEEVTATCDLT 126
Query 61 ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV 120
ML + ++ ++G + G +D ST+D S I+K + G +APV
Sbjct 127 FAMLADPESAIDVACGKNGAIFGISSGKGYVDVSTVDVASSILISKQIKDTGALFLEAPV 186
Query 121 SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS 180
SG A+ G L F+ D L+E+ L MGK+ Y GEVG+G K+ N+I+G
Sbjct 187 SGSKKPAEDGQLIFLTAGDKPLYEKAAPFLDIMGKSKFYLGEVGNGAAMKLVVNMIMGSM 246
Query 181 MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT 240
M + AEG+ L K+G+DP +L V++ + + P + + Y F
Sbjct 247 MASFAEGILLSQKVGLDPNVLVEVVSQGA-------INAPMYSLKGPSMIKSVYPTAFPL 299
Query 241 QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQ 289
+ KD+ LA+ A V Q +A + Y+ G + DFS++I+
Sbjct 300 KHQQKDMRLALGLAESVSQSTPIAAAANELYKVAKSYGLSDEDFSAVIE 348
Lambda K H a alpha
0.319 0.135 0.392 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1087632
Database: 816c63130a01934fb04ccbea3a9ffb01.SwissProt.fasta
Posted date: May 18, 2024 8:23 PM
Number of letters in database: 5,052
Number of sequences in database: 16
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
