BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 17c3e9a8f1a294ec483d29c3e3c999eb.SwissProt.fasta
12 sequences; 6,936 total letters
Query= ACIAD1611
Length=548
Score E
Sequences producing significant alignments: (Bits) Value
P39062 Acetyl-coenzyme A synthetase [Bacillus subtilis (strain 168)] 271 3e-87
Q7TN78 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Rattus no... 259 2e-82
P0C7M7 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Homo sapi... 257 1e-81
Q80W40 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Mus muscu... 252 1e-79
A4YDT1 4-hydroxybutyrate--CoA ligase 1 [Metallosphaera sedula (st... 238 9e-75
Q3UNX5 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Mus muscu... 239 9e-75
Q53FZ2 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Homo sapi... 238 1e-74
Q5REV5 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Pongo abe... 238 3e-74
Q6SKG1 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Rattus no... 237 4e-74
Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial [Homo sapi... 233 1e-72
O70490 Acyl-coenzyme A synthetase ACSM2, mitochondrial [Rattus no... 228 1e-70
Q08AH1 Acyl-coenzyme A synthetase ACSM1, mitochondrial [Homo sapi... 227 3e-70
>P39062 Acetyl-coenzyme A synthetase [Bacillus subtilis (strain
168)]
Length=572
Score = 271 bits (694), Expect = 3e-87
Identities = 190/554 (34%), Positives = 289/554 (52%), Gaps = 20/554 (4%)
Query 1 MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVG---QNKIALIWEGLEGETKQ 57
++ E+ Y+ FD + + +NA E R+ +NK+AL ++ + + K
Sbjct 15 LKNYEETYRHFDWAEAEKHFSWHETGKLNAAYEAIDRHAESFRKNKVALYYKDAKRDEK- 73
Query 58 FTFDELATYSGQLANYFKSQG-VQPGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAF 116
+TF E+ S + N + G V+ G + +PR+PEL +L ++GAI PLF AF
Sbjct 74 YTFKEMKEESNRAGNVLRRYGNVEKGDRVFIFMPRSPELYFIMLGAIKIGAIAGPLFEAF 133
Query 117 ESKAIEHRLSVAQTQLVVTNKE-----QAAKLNAVNNLKVLTVEKDSFDILDQPDFWNAL 171
A++ RL ++ ++VVT E KL + ++ V+ E +S + D A
Sbjct 134 MEGAVKDRLENSEAKVVVTTPELLERIPVDKLPHLQHVFVVGGEAESGTNIINYD--EAA 191
Query 172 KHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFW 231
K + E + D FL+ +TSG+TG K V +A++ + L + D +W
Sbjct 192 KQESTRLDIEWMDKKDGFLLHYTSGSTGTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYW 251
Query 232 NLADPGWAYGLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFF 291
ADPGW G YGI P G + ++ FS + I++ V+ +PTAFRM
Sbjct 252 CTADPGWVTGTVYGIFAPWLNGATNVIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLM 311
Query 292 GFKEKFDAEIK-DYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQYGQTELG-MVIANHHA 349
G ++ A+ LR V S GEPL PEV+ W + I+D + TE G +I N+
Sbjct 312 GAGDEMAAKYDLTSLRHVLSVGEPLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPC 371
Query 350 LEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSA-ASPLFWFTGYGENNRSA 408
++ +K GS G IPG ++D EL +G LAI S + E S
Sbjct 372 MD--IKPGSMGKPIPGVEAAIVDNQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESY 429
Query 409 FV-GQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIG 467
F+ G +Y++GD+ M+ G F GR+DDVI TSG RVGPF+VES L+E + E+ VIG
Sbjct 430 FMPGGWYVSGDSAYMDEEGYFWFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIG 489
Query 468 KPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTAS 527
KPD +R EI+KAF+ L+ + + L E+++ +V+ L+ HA P+EIEF D+LPKT S
Sbjct 490 KPDPVRGEIIKAFIALREGF--EPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRS 547
Query 528 GKIQRGVLKQQEIS 541
GKI R VLK E++
Sbjct 548 GKIMRRVLKAWELN 561
>Q7TN78 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Rattus
norvegicus]
Length=580
Score = 259 bits (662), Expect = 2e-82
Identities = 170/520 (33%), Positives = 268/520 (52%), Gaps = 38/520 (7%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
AL W +G+ +++F EL + S + AN K G+Q G +A +LPR PE + +A
Sbjct 76 ALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACM 135
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVN----NLKVLTVEKDSF 159
R G ++ P K I +RL ++ + +V ++E A ++++ NLK
Sbjct 136 RTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSIASECPNLKT-------- 187
Query 160 DILDQPDFWNALKHFDAQYQSEMITFN-------DHFLMMFTSGTTGLAKPVPVPLKAI- 211
+L P W+ F QS N + + FTSGTTG K ++
Sbjct 188 KLLVSPHRWDGWLSFQELLQSASEEHNCVQTGSQEPMAIYFTSGTTGSPKMAQHSQSSLG 247
Query 212 LSFKGYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDEQG-FSVDRAIE 270
+ + + + L SD WN++D GW + G + + F+ D ++
Sbjct 248 IGYALCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFNTDTFLD 307
Query 271 LIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDY----LRVVSSAGEPLTPEVVHWFKND 326
+ Y ++ L +PT +RM ++K Y LR + GEPL PEV+ +K
Sbjct 308 TLTSYPITTLCSAPTVYRMLV------QQDLKRYQFKRLRHCLTGGEPLNPEVLEQWKAQ 361
Query 327 LDINIYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVL 386
+ +Y+ YGQTE+G++ AN E +K GS G + Y ++DEH L S G +
Sbjct 362 TGLELYEGYGQTEVGIICANRKGEE--IKPGSMGKGVVPYDVQIIDEHGNILPSGKEGEI 419
Query 387 AIDSAAS-PLFWFTGYGENNR---SAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSG 442
A+ + P +F+ Y +N + +YITGD M+ G + FVGR DDVI +SG
Sbjct 420 ALRLGSDRPFCFFSEYVDNPEKTDATIRRNFYITGDRGVMDDDGYLWFVGRADDVIISSG 479
Query 443 YRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQY 502
YR+GPF+VES L+E V+ESAV+ PD IR E+VKAF+VL + +KS + L+ +L+ +
Sbjct 480 YRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPFKSSNREKLTAELQDH 539
Query 503 VRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEISR 542
V+ + + YP+++EFV +LPKT +GKI+R VL+ QE R
Sbjct 540 VKNSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGR 579
>P0C7M7 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Homo
sapiens]
Length=580
Score = 257 bits (657), Expect = 1e-81
Identities = 170/513 (33%), Positives = 265/513 (52%), Gaps = 30/513 (6%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
AL W +G+ +++F EL + S + AN K G+Q G +A +LPR PE + +A
Sbjct 76 ALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACI 135
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILD 163
R G I+ P +K I +RL ++ + +V ++E A + ++ VL +L
Sbjct 136 RTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESI----VLECPDLKTKLLV 191
Query 164 QPDFWNALKHFDA--QYQSEMITF-----NDHFLMMFTSGTTGLAKPVPVPLKAI-LSFK 215
P WN F Q+ SE + + + FTSGTTG K ++ + F
Sbjct 192 SPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFT 251
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDEQG-FSVDRAIELIKK 274
+ + L SD WN++D GW + G + + F D ++ +
Sbjct 252 LCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTT 311
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDY----LRVVSSAGEPLTPEVVHWFKNDLDIN 330
Y ++ L PT +RM ++K Y LR + GEPL PEV+ ++ +
Sbjct 312 YPITTLCSPPTVYRMLV------QKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLE 365
Query 331 IYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAID- 389
+Y+ YGQTE+GM+ AN E +K GS G + Y ++DE+ L G +A+
Sbjct 366 LYEGYGQTEVGMICANQKGQE--IKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRL 423
Query 390 SAASPLFWFTGYGENNRSAFV---GQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVG 446
P +F+ Y +N + G +Y+TGD M++ G FVGR DDVI +SGYR+G
Sbjct 424 KPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIG 483
Query 447 PFDVESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGR 506
PF+VES L+E V+ESAV+ PD IR E+VKAFVVL + +KS + L+ +L+ +V+
Sbjct 484 PFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKS 543
Query 507 LSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQE 539
+ + YP+++EFV +LPKT +GKI+R VL+ QE
Sbjct 544 TAPYKYPRKVEFVQELPKTITGKIKRNVLRDQE 576
>Q80W40 Acyl-coenzyme A synthetase ACSM4, mitochondrial [Mus musculus]
Length=580
Score = 252 bits (643), Expect = 1e-79
Identities = 165/516 (32%), Positives = 263/516 (51%), Gaps = 30/516 (6%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
AL W +G+ +++F EL + S + AN K G+Q G +A +LPR PE + +A
Sbjct 76 ALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACM 135
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILD 163
R G ++ P K I +RL ++ + +V ++E A ++++ V +L
Sbjct 136 RTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSI----VSECPSLKTKLLV 191
Query 164 QPDFWNALKHFDAQYQSEMITFN-------DHFLMMFTSGTTGLAKPVPVPLKAI-LSFK 215
P W+ +F QS N + + FTSGTTG K ++ + +
Sbjct 192 SPHHWDGWLNFQELLQSASEEHNCVETGSQEPMAIYFTSGTTGSPKMAQHSQGSLGIGYT 251
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDEQG-FSVDRAIELIKK 274
+ + L SD WN++D GW + G + + F D ++ +
Sbjct 252 LCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFDTDIFLDTLTT 311
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDY----LRVVSSAGEPLTPEVVHWFKNDLDIN 330
Y ++ L +PT +RM ++K Y LR + GEPL PEV+ +K +
Sbjct 312 YPITTLCSAPTVYRMLV------QKDLKRYQFKRLRHCLTGGEPLNPEVLEQWKMQTGLE 365
Query 331 IYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDS 390
+Y+ YGQTE+G++ AN +K GS G + Y ++DE+ L S G +A+
Sbjct 366 LYEGYGQTEVGIICANRKG--EAIKPGSMGKGVVPYDVQIIDENGNILPSGKEGEIALRL 423
Query 391 AAS-PLFWFTGYGENNR---SAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVG 446
+ P +F+ Y +N + +Y+TGD M+ G FVGR DDVI +SGYR+G
Sbjct 424 KSDRPFCFFSEYVDNPEKTDATIRRNFYVTGDRGVMDDDGYFWFVGRADDVIISSGYRIG 483
Query 447 PFDVESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGR 506
PF+VES L+E V+ESAV+ PD IR E+VKAF+VL + YK + L+ +L+ +V+
Sbjct 484 PFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPYKCSNREKLTAELQDHVKNS 543
Query 507 LSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEISR 542
+ + YP+++EFV +LPKT +GKI+R VL+ QE R
Sbjct 544 TAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGR 579
>A4YDT1 4-hydroxybutyrate--CoA ligase 1 [Metallosphaera sedula
(strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)]
Length=564
Score = 238 bits (608), Expect = 9e-75
Identities = 169/508 (33%), Positives = 272/508 (54%), Gaps = 24/508 (5%)
Query 42 NKIALIWEGLE-GETKQFTFDELATYSGQLANYFKSQGVQPGQCIAGLLPRTPELLITIL 100
+K ALIW + GE + ++ EL+ S ++ + + G++ G + + P L
Sbjct 55 SKTALIWRDINTGEEAKLSYHELSLMSNRVLSTLRKHGLKKGDVVYLMTKVHPMHWAVFL 114
Query 101 ATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLN-AVNNLKVLTVEKDSF 159
A + G + P T +++R S + ++++ +A+ + A+ +LKV + F
Sbjct 115 AVIKGGFVMVPSATNLTVAEMKYRFSDLKPSAIISDSLRASVMEEALGSLKV-----EKF 169
Query 160 DILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFK-GYM 218
I + + WN+L+ + + E D + FTSGTTG+ K V + +S+ G +
Sbjct 170 LIDGKRETWNSLEDESSNAEPEDTRGEDVIINYFTSGTTGMPKRV---IHTAVSYPVGSI 226
Query 219 THA--VGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSII-LDEQG-FSVDRAIELIKK 274
T A VG+ +SD NL+ GWA + PL +G +++ ++ +G R + ++
Sbjct 227 TTASIVGVRESDLHLNLSATGWAKFAWSSFFSPLLVGATVVGINYEGKLDTRRYLGEVEN 286
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQ 334
V++ PTA+R F D + LR V SAGEPL PEV+ +K+ ++ I D
Sbjct 287 LGVTSFCAPPTAWRQFITLD--LDQFRFERLRSVVSAGEPLNPEVIKIWKDKFNLTIRDF 344
Query 335 YGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSD-SIGVLAIDSAAS 393
YGQTE ++ N L+ VK GS G P Y +LD+ +E++ +G + +
Sbjct 345 YGQTETTAMVGNFPFLK--VKPGSMGKPHPLYDIRLLDDEGKEITKPYEVGHITVKLNPR 402
Query 394 PLFWFTGYGEN--NRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVE 451
P+ F GY + N +F YY TGD + G FVGR DDVI TS YRVGPF+VE
Sbjct 403 PIGLFLGYSDEKKNMESFREGYYYTGDKAYFDEEGYFYFVGRGDDVIKTSDYRVGPFEVE 462
Query 452 STLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKHA 511
S LLE V E+AV+G PD +R ++VKA++VLK Y + L+E++++ ++ LS +
Sbjct 463 SALLEHPAVAEAAVVGVPDTVRWQLVKAYIVLKKGY--MPSKELAEEIREKMKTLLSPYK 520
Query 512 YPKEIEFVDQLPKTASGKIQRGVLKQQE 539
P+ IEFVD+LPKT SGKI+R L+++E
Sbjct 521 VPRIIEFVDELPKTISGKIRRVELRKRE 548
>Q3UNX5 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Mus musculus]
Length=580
Score = 239 bits (609), Expect = 9e-75
Identities = 163/509 (32%), Positives = 260/509 (51%), Gaps = 22/509 (4%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
A W GE +++F+EL S + AN ++ +Q G + +LP+ PE + +A
Sbjct 76 AFWWIDGNGEELRWSFEELGLLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACL 135
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILD 163
R G + P T K I +RL ++ + ++T+ A ++AV K +
Sbjct 136 RTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDDTLAPAVDAVA-AKCENLHSKLIVSQH 194
Query 164 QPDFWNALKHFDAQYQSEMITFND--HFLMM---FTSGTTGLAKPVPVPLKAI---LSFK 215
+ W LK +Y S+ T D H MM FTSGTTG K + + LS
Sbjct 195 SREGWGNLKEM-MKYASDSHTCVDTKHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVN 253
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDE-QGFSVDRAIELIKK 274
G + L SD WN +D GWA + + P + G + F ++ + K
Sbjct 254 GRFW--LDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSK 311
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQ 334
+ ++ +PTA+RM + + + L+ SAGEP+ PEV+ ++ ++IY+
Sbjct 312 FPITVFCSAPTAYRMLV--QNDMSSYKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEG 369
Query 335 YGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSAAS- 393
YGQTE ++ N ++ +K GS G P + +LDE+ L G +A+
Sbjct 370 YGQTETVLICGNFKGMK--IKPGSMGKPSPAFDVKILDENGATLPPGQEGDIALQVLPER 427
Query 394 PLFWFTGYGEN---NRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDV 450
P FT Y +N S G +YITGD M+ G FV R DD+I +SGYR+GPF+V
Sbjct 428 PFGLFTHYVDNPSKTASTLRGSFYITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEV 487
Query 451 ESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKH 510
ES L+E + ESAV+ PD IR E+VKAF+VL YKS + L ++++++V+ + +
Sbjct 488 ESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPY 547
Query 511 AYPKEIEFVDQLPKTASGKIQRGVLKQQE 539
YP+++EF+++LPKT SGK++R L+++E
Sbjct 548 KYPRKVEFIEELPKTVSGKVKRNELRKKE 576
>Q53FZ2 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Homo
sapiens]
Length=586
Score = 238 bits (608), Expect = 1e-74
Identities = 167/543 (31%), Positives = 263/543 (48%), Gaps = 37/543 (7%)
Query 22 IGHPQSINAYEECCGRYVGQNKI-------ALIWEGLEGETKQFTFDELATYSGQLANYF 74
+G P+ N ++ ++ + K A W GE +++F+EL + S + AN
Sbjct 52 LGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANIL 111
Query 75 KSQ-GVQPGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLV 133
+Q G + +LPR PE + +A R G + P T K I +RL ++ +
Sbjct 112 SEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCI 171
Query 134 VTNKEQAAKLNAV-----NNLKVLTVEKDSFDILDQPDFWNALKHFDAQYQSEMITFNDH 188
+TN A ++AV N L V ++S + + +KH + N+
Sbjct 172 ITNDVLAPAVDAVASKCENLHSKLIVSENSRE--GWGNLKELMKHASDSHTCVKTKHNEI 229
Query 189 FLMMFTSGTTGLAKPVPVPLKAI---LSFKGYMTHAVGLNQSDSFWNLADPGWAYGLYYG 245
+ FTSGT+G K + LS G + L SD WN +D GWA +
Sbjct 230 MAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFW--LDLTPSDVMWNTSDTGWAKSAWSS 287
Query 246 ITGPLSLGHSIILDE-QGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDY 304
+ P G + F ++ + KY ++ +PT +RM +I Y
Sbjct 288 VFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLV------QNDITSY 341
Query 305 ----LRVVSSAGEPLTPEVVHWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAG 360
L+ SAGEP+TP+V ++N ++IY+ YGQTE ++ N ++ +K GS G
Sbjct 342 KFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMK--IKPGSMG 399
Query 361 YAIPGYRFVVLDEHHQELSSDSIGVLAIDSAAS-PLFWFTGYGEN---NRSAFVGQYYIT 416
P + ++D + L G + I + P FT Y +N S G +YIT
Sbjct 400 KPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYIT 459
Query 417 GDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEI 476
GD M+ G FV R DDVI +SGYR+GPF+VE+ L E V ESAV+ PD IR E+
Sbjct 460 GDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEV 519
Query 477 VKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLK 536
VKAFVVL YKS + L ++++++V+ + + YP+++EF+ +LPKT SGK +R L+
Sbjct 520 VKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELR 579
Query 537 QQE 539
++E
Sbjct 580 KKE 582
>Q5REV5 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Pongo
abelii]
Length=586
Score = 238 bits (606), Expect = 3e-74
Identities = 166/539 (31%), Positives = 262/539 (49%), Gaps = 29/539 (5%)
Query 22 IGHPQSINAYEECCGRYVGQNKI-------ALIWEGLEGETKQFTFDELATYSGQLANYF 74
+G P+ N ++ ++ + K A W GE +++F+EL + S + AN
Sbjct 52 LGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEVRWSFEELGSLSRKFANIL 111
Query 75 KSQ-GVQPGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLV 133
+Q G + +LPR PE + +A R G + P T K I +RL ++ +
Sbjct 112 SEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCI 171
Query 134 VTNKEQAAKLNAV-----NNLKVLTVEKDSFDILDQPDFWNALKHFDAQYQSEMITFNDH 188
+TN A ++AV N L V ++S + + +KH + N+
Sbjct 172 ITNDVLAPAVDAVAPKCENLHSKLIVSENSRE--GWGNLKEMMKHASDSHTCVKTKHNEI 229
Query 189 FLMMFTSGTTGLAKPVPVPLKAI---LSFKGYMTHAVGLNQSDSFWNLADPGWAYGLYYG 245
+ FTSGT+G K + LS G + L SD WN +D GWA +
Sbjct 230 MAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFW--LDLTPSDVMWNTSDTGWAKSAWSS 287
Query 246 ITGPLSLGHSIILDE-QGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDY 304
+ P G + F ++ + KY ++ +PT +RM + + K
Sbjct 288 VFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQ-NDMASYKFKSL 346
Query 305 LRVVSSAGEPLTPEVVHWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAGYAIP 364
VS AGEP+TP+V ++N ++IY+ YGQTE ++ N ++ +K GS G P
Sbjct 347 KHCVS-AGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMK--IKPGSMGKPSP 403
Query 365 GYRFVVLDEHHQELSSDSIGVLAIDSAAS-PLFWFTGYGEN---NRSAFVGQYYITGDTV 420
+ ++D + L G + I + P FT Y +N S G +YITGD
Sbjct 404 AFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRG 463
Query 421 KMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF 480
M+ G FV R DDVI +SGYR+GPF+VE+ L E V ESAV+ PD IR E+VKAF
Sbjct 464 YMDEDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAF 523
Query 481 VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQE 539
VVL YKS + L ++++++V+ + + YP+++EF+ +LPKT SGK +R L+++E
Sbjct 524 VVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKE 582
>Q6SKG1 Acyl-coenzyme A synthetase ACSM3, mitochondrial [Rattus
norvegicus]
Length=580
Score = 237 bits (605), Expect = 4e-74
Identities = 162/513 (32%), Positives = 259/513 (50%), Gaps = 30/513 (6%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
A W G+ +++F+EL + S + AN ++ +Q G + +LP+ PE + +A
Sbjct 76 AFWWVDGNGKEVRWSFEELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACL 135
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILD 163
R G + P T K I +RL ++++ ++T+ A ++ V K +
Sbjct 136 RTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDTLAPAVDIVA-AKCENLHSKLIVSQH 194
Query 164 QPDFWNALKHFDAQYQSEMIT-----FNDHFLMMFTSGTTGLAKPVPVPLKAI---LSFK 215
+ W LK +Y S+ T N+ + FTSGTTG K + + LS
Sbjct 195 SREGWGNLKEM-MKYASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVN 253
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDE-QGFSVDRAIELIKK 274
G + L SD WN +D GWA + + P + G + F ++ + K
Sbjct 254 GRFW--LDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSK 311
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDY----LRVVSSAGEPLTPEVVHWFKNDLDIN 330
+ ++ +PTA+RM +I Y L+ SAGEP+ PEV+ +K ++
Sbjct 312 FPITVFCSAPTAYRMLI------QNDITSYKFNSLKHCVSAGEPINPEVMEQWKKKTGLD 365
Query 331 IYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDS 390
IY+ YGQTE ++ N ++ +K GS G P + +LDE+ L G +A+
Sbjct 366 IYEGYGQTETVLICGNFKGMK--IKPGSMGKPSPAFNVEILDENGTILPPGQEGDIAVQV 423
Query 391 AAS-PLFWFTGYGEN---NRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVG 446
P FT Y +N S G +YITGD M+ G FV R DDVI +SGYR+G
Sbjct 424 LPDRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDEDGYFWFVARSDDVILSSGYRIG 483
Query 447 PFDVESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGR 506
PF+VES L+E + ESAV+ PD IR E+VKAF+VL YK + L ++++++V+
Sbjct 484 PFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKLHDQEQLKKEIQEHVKKT 543
Query 507 LSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQE 539
+ + YP++IEF+++LPKT SGK++R L+++E
Sbjct 544 TAPYKYPRKIEFIEELPKTVSGKVKRNELRRKE 576
>Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial [Homo
sapiens]
Length=579
Score = 233 bits (595), Expect = 1e-72
Identities = 164/510 (32%), Positives = 256/510 (50%), Gaps = 25/510 (5%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYFKSQ-GVQPGQCIAGLLPRTPELLITILATW 103
A W G +++F+EL S + AN G+QPG + +LPR PE + +A
Sbjct 77 AFWWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACM 136
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVN----NLKVLTVEKDSF 159
R G + P T K +++RL ++ + ++T+ A +++A++ +L+ + DS
Sbjct 137 RTGTVMIPGVTQLTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDS- 195
Query 160 DILDQPDFWN---ALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAI-LSFK 215
+P + N L+ ++ D + FTSGTTG K V + L F
Sbjct 196 ---SRPGWLNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFV 252
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDEQGFSVDRAIEL--IK 273
V L +SD FWN D GW + + G I + E VD + L +
Sbjct 253 ASGRRWVALTESDIFWNTTDTGWVKAAWT-LFSAWPNGSCIFVHELP-RVDAKVILNTLS 310
Query 274 KYKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYD 333
K+ ++ L PT FR+ +E LR + GE L P+V +K+ + +Y+
Sbjct 311 KFPITTLCCVPTIFRLLV--QEDLTRYQFQSLRHCLTGGEALNPDVREKWKHQTGVELYE 368
Query 334 QYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSAAS 393
YGQ+E ++ AN ++ +K GS G A P Y ++D+ L G +A+ +
Sbjct 369 GYGQSETVVICANPKGMK--IKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPT 426
Query 394 -PLFWFTGYGENNRSAFV---GQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFD 449
P +F Y +N G +YITGD +M+ G F+GR DDVI +S YR+GP +
Sbjct 427 RPFCFFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVE 486
Query 450 VESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSK 509
VES L E VLESAV+ PD IR E+VKAF+VL Y S ++L+ +L+++V+ +
Sbjct 487 VESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQEHVKRVTAP 546
Query 510 HAYPKEIEFVDQLPKTASGKIQRGVLKQQE 539
+ YP+++ FV +LPKT SGKIQR L+ QE
Sbjct 547 YKYPRKVAFVSELPKTVSGKIQRSKLRSQE 576
>O70490 Acyl-coenzyme A synthetase ACSM2, mitochondrial [Rattus
norvegicus]
Length=572
Score = 228 bits (580), Expect = 1e-70
Identities = 161/508 (32%), Positives = 251/508 (49%), Gaps = 21/508 (4%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYFKSQ-GVQPGQCIAGLLPRTPELLITILATW 103
AL W GE ++ F EL+ S Q AN G+Q G +A +LPR PE + L
Sbjct 68 ALWWMNGSGEELKWNFRELSEISKQTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCM 127
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVN------NLKVLTVEKD 157
R G ++ P T +S I +RL ++ + +V E +++AV +K+L EK+
Sbjct 128 RSGLVFMPGTTQMKSTDILYRLQSSKARAIVAGDEVVQEVDAVAPDCSFLKIKLLVSEKN 187
Query 158 SFDILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGY 217
L+ F LK +Q + + FTSGT+G K + L K
Sbjct 188 REGWLN---FKALLKDASPIHQCVETVSQESAAIYFTSGTSGPPK-MAEHSHCSLGLKAK 243
Query 218 MTHA-VGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDE-QGFSVDRAIELIKKY 275
M GL SD+ W ++D GW + P LG I + F ++++ Y
Sbjct 244 MDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSY 303
Query 276 KVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQY 335
++ L+G+P +RM ++ + +L S GE L PE + +K + I + Y
Sbjct 304 PINTLLGAPLIYRMLL--QQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLEIREIY 361
Query 336 GQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAID-SAASP 394
GQTE G+ ++ VK G G AI Y V+DE L G +A+ P
Sbjct 362 GQTETGITCRVSRTMK--VKPGYLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRP 419
Query 395 LFWFTGYGENNRSAFV---GQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVE 451
+ F+GY +N + G +++ GD + G F+GR DD+I +SGYR+GP +VE
Sbjct 420 IGMFSGYVDNPKKTQANIRGDFWLLGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVE 479
Query 452 STLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKHA 511
+ L+E V+E+AVI PD IR E+VKAFVVL ++ S L++ L+++V+ + +
Sbjct 480 NALMEHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLTKVLQEHVKSVTAPYK 539
Query 512 YPKEIEFVDQLPKTASGKIQRGVLKQQE 539
YP+++EFV LPKT +GKI+R L+ +E
Sbjct 540 YPRKVEFVLDLPKTITGKIERAKLRAKE 567
>Q08AH1 Acyl-coenzyme A synthetase ACSM1, mitochondrial [Homo
sapiens]
Length=577
Score = 227 bits (578), Expect = 3e-70
Identities = 159/513 (31%), Positives = 268/513 (52%), Gaps = 22/513 (4%)
Query 45 ALIWEGLEGETKQFTFDELATYSGQLANYF-KSQGVQPGQCIAGLLPRTPELLITILATW 103
A W +G+ +++F E+ + ++AN F ++ G+Q G +A +LPR PE + +
Sbjct 73 AFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCM 132
Query 104 RMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNN------LKVLTVEKD 157
R G I+ P ++K I +RL +++ + +VT A++++++ + K+L +
Sbjct 133 RTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHS 192
Query 158 SFDILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAIL--SFK 215
LD F + +K ++ D ++ FTSGTTG K L SF
Sbjct 193 REGWLD---FRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFP 249
Query 216 GYMTHAVGLNQSDSFWNLADPGWAYGLYYGITGPLSLGHSIILDE-QGFSVDRAIELIKK 274
G L SD W L+D GW + + P + G ++ + F I+ + K
Sbjct 250 G-SRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLK 308
Query 275 YKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQ 334
Y +++ G + +RM ++ F + L + GE + P+ +K + +Y+
Sbjct 309 YPINHFWGVSSIYRMIL--QQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYEN 366
Query 335 YGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAID-SAAS 393
YGQ+E G++ A + ++ +K G G A P Y V+D+ L ++ G + I
Sbjct 367 YGQSETGLICATYWGMK--IKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVR 424
Query 394 PLFWFTGY-GENNRSAFV--GQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDV 450
P+ F Y G+ ++A V G +Y TGD KM+ G I F+GR DD+I SGYR+GP +V
Sbjct 425 PVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEV 484
Query 451 ESTLLECQEVLESAVIGKPDAIRTEIVKAFVVLKSQYKSQADQSLSEKLKQYVRGRLSKH 510
ES L+E V ESAV+G PD IR E+VKAF+VL Q+ S L+++L+Q+V+ + +
Sbjct 485 ESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPY 544
Query 511 AYPKEIEFVDQLPKTASGKIQRGVLKQQEISRM 543
YP+++EFV +LPKT +GKI+R L+++E +M
Sbjct 545 KYPRKVEFVSELPKTITGKIERKELRKKETGQM 577
Lambda K H a alpha
0.320 0.137 0.404 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3118500
Database: 17c3e9a8f1a294ec483d29c3e3c999eb.SwissProt.fasta
Posted date: May 19, 2024 10:47 PM
Number of letters in database: 6,936
Number of sequences in database: 12
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
