BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 02477935e68713be1869007a42485f71.SwissProt.fasta
17 sequences; 7,718 total letters
Query= ACIAD1707
Length=452
Score E
Sequences producing significant alignments: (Bits) Value
Q59092 3-carboxy-cis,cis-muconate cycloisomerase [Acinetobacter b... 880 0.0
O31385 3-carboxy-cis,cis-muconate cycloisomerase [Bradyrhizobium ... 398 4e-139
Q9I6Q8 3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas aer... 392 8e-137
P32427 3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas put... 378 1e-131
O42889 Uncharacterized protein C8E4.05c [Schizosaccharomyces pomb... 327 3e-111
A0A0U2UYC4 Trans-aconitate decarboxylase 1 [Ustilago maydis] 294 4e-98
Q58339 Adenylosuccinate lyase [Methanocaldococcus jannaschii (str... 233 8e-75
O27580 Adenylosuccinate lyase [Methanothermobacter thermautotroph... 223 3e-71
Q9UZ99 Adenylosuccinate lyase [Pyrococcus abyssi (strain GE5 / Or... 210 4e-66
O58582 Adenylosuccinate lyase [Pyrococcus horikoshii (strain ATCC... 209 5e-66
Q7A0G9 Adenylosuccinate lyase [Staphylococcus aureus (strain MW2)] 183 4e-56
P12047 Adenylosuccinate lyase [Bacillus subtilis (strain 168)] 172 6e-52
Q9X0I0 Adenylosuccinate lyase [Thermotoga maritima (strain ATCC 4... 164 6e-49
P30566 Adenylosuccinate lyase [Homo sapiens] 95.1 3e-24
P54822 Adenylosuccinate lyase [Mus musculus] 94.0 8e-24
P21265 Adenylosuccinate lyase [Gallus gallus] 88.6 5e-22
P39461 Fumarate hydratase class II [Saccharolobus solfataricus (s... 87.0 1e-21
>Q59092 3-carboxy-cis,cis-muconate cycloisomerase [Acinetobacter
baylyi (strain ATCC 33305 / BD413 / ADP1)]
Length=451
Score = 880 bits (2275), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%), Gaps = 0/451 (0%)
Query 1 MSQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAI 60
MSQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAI
Sbjct 1 MSQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAI 60
Query 61 DKIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCR 120
DKIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCR
Sbjct 61 DKIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCR 120
Query 121 DALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDR 180
DALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDR
Sbjct 121 DALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDR 180
Query 181 INAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASV 240
INAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASV
Sbjct 181 INAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASV 240
Query 241 LGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVP 300
LGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVP
Sbjct 241 LGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVP 300
Query 301 ALMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNI 360
ALMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNI
Sbjct 301 ALMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNI 360
Query 361 ECTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPS 420
ECTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPS
Sbjct 361 ECTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPS 420
Query 421 QLDEIFKPESYLGNIQDQIDAVLQEAKGEAK 451
QLDEIFKPESYLGNIQDQIDAVLQEAKGEAK
Sbjct 421 QLDEIFKPESYLGNIQDQIDAVLQEAKGEAK 451
>O31385 3-carboxy-cis,cis-muconate cycloisomerase [Bradyrhizobium
diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628
/ NBRC 14792 / USDA 110)]
Length=451
Score = 398 bits (1022), Expect = 4e-139
Identities = 206/443 (47%), Positives = 288/443 (65%), Gaps = 2/443 (0%)
Query 1 MSQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAI 60
+S L A + + DR+ + M++ E ALA+A+A GVIP +A IE A K A
Sbjct 5 LSPLLAPMLSSAAMRAACDDRSTLQNMLDFEAALARAEAATGVIPAAAVGPIETACKAAT 64
Query 61 DKIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCR 120
D ALA A +GN+AIP VK LTA V AD +AARYVHWGATSQD++DTA +L R
Sbjct 65 --FDIAALAEAATRSGNLAIPLVKALTANVAKADAEAARYVHWGATSQDVIDTATMLTLR 122
Query 121 DALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDR 180
A+ + + + + + A+ +R+ M+ RTWLQ ALP+ G K A +A++ R R
Sbjct 123 AAIDALDADLSRAIKGFAALARNHRNTAMVARTWLQHALPMPFGLKAAEYAASLARARCR 182
Query 181 INAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASV 240
+ + L Q GGA G+LA+L D+G +V E A++L L WH RDRI E AS
Sbjct 183 LRRLSRDGLALQFGGAAGTLAALGDKGLVVAERLAQELNLPLPEAPWHTHRDRIAEAASA 242
Query 241 LGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVP 300
L I+ G+ GK+ARD SLMMQT++AE FEP +GRGGSSTMPHKRNPVAAAS L A P
Sbjct 243 LAILAGSCGKIARDVSLMMQTDVAEAFEPAGEGRGGSSTMPHKRNPVAAASALGCATMAP 302
Query 301 ALMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNI 360
L ++I+ + VQ+HERS G WHAEW +LP++ +T+GAL +D+ +G++V+A M N+
Sbjct 303 QLAATIFAAQVQDHERSAGPWHAEWPTLPQLMLVTSGALAAIVDIAEGLDVDAARMRSNL 362
Query 361 ECTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPS 420
+ THGLIMAEAV ALA +G+ +AHH++EAA K AVAE+KHL+++++ +V + +P
Sbjct 363 DATHGLIMAEAVTFALAERIGKSDAHHLIEAASKRAVAEKKHLREVLAADSQVTAHLSPE 422
Query 421 QLDEIFKPESYLGNIQDQIDAVL 443
++ +F+P +Y G Q ID +L
Sbjct 423 KIAALFEPMAYQGASQAMIDRLL 445
>Q9I6Q8 3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas
aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
14847 / LMG 12228 / 1C / PRS 101 / PAO1)]
Length=459
Score = 392 bits (1008), Expect = 8e-137
Identities = 204/444 (46%), Positives = 288/444 (65%), Gaps = 2/444 (0%)
Query 2 SQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAID 61
+QL+ + F + +FSDR + M++ E ALA+A+A+ GV+P +A IE A + +
Sbjct 7 NQLFDAYFMAAPMRAVFSDRGRLQGMLDFEAALARAEARTGVVPATAVAPIEAACRAEL- 65
Query 62 KIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRD 121
D ALA A AGN AIP VK L V D +A RYVH GATSQD +D+ +LQ R
Sbjct 66 -YDPLALAEAVATAGNSAIPLVKALGRQVAAGDAEAERYVHLGATSQDAMDSGLVLQLRR 124
Query 122 ALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRI 181
ALA+++ +Q+ E QA+ + + GRTWLQ A P+TLG KLA A R R+
Sbjct 125 ALALLEQDLQRLAEVLADQAERHADTPLAGRTWLQHATPVTLGMKLAGLLGALTRHRQRL 184
Query 182 NAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASVL 241
++ R+LV Q GGA G+LA+L +Q V A A++L L WH +RDR+VE ASVL
Sbjct 185 RELRPRLLVLQFGGASGTLAALGEQALPVAAALAEELGLALPEQPWHTQRDRLVEFASVL 244
Query 242 GIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPA 301
G++ G++GK RD SL+MQTE EVFEP GRGGSSTMPHKRNPV++A ++AAA R P
Sbjct 245 GLVAGSLGKFGRDVSLLMQTEAGEVFEPAGAGRGGSSTMPHKRNPVSSAVLIAAATRAPG 304
Query 302 LMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIE 361
L+S+++ +M QEHERSLG WHAEW +LPE+ L AGAL++ + +L+G+EV+A+ M +N+
Sbjct 305 LVSTLFAAMPQEHERSLGLWHAEWETLPELCCLVAGALQQAIGLLEGLEVDAQRMRRNLG 364
Query 362 CTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQ 421
THGL++AEAV +ALA +GR AHH+VE C+ AV +++ L+ ++ + V + +
Sbjct 365 LTHGLVLAEAVSIALARRIGREAAHHLVEQCCRRAVEQRRELRAVLGEEARVSAELSGDE 424
Query 422 LDEIFKPESYLGNIQDQIDAVLQE 445
LD + P YLG + ++ L E
Sbjct 425 LDRLLDPAHYLGQARAWVERALAE 448
>P32427 3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas
putida]
Length=422
Score = 378 bits (970), Expect = 1e-131
Identities = 199/422 (47%), Positives = 272/422 (64%), Gaps = 2/422 (0%)
Query 2 SQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAID 61
+QL+ + F + EIFSDR + M++ E ALA+A+A G++P SA IE A K +
Sbjct 3 NQLFDAYFTAPAMREIFSDRGRLQGMLDFEAALARAEAAAGLVPHSAVAAIEAACKA--E 60
Query 62 KIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRD 121
+ D ALA A AGN AIP VK L ++ +A RYVH GATSQD +DT +LQ RD
Sbjct 61 RYDVGALANAIATAGNSAIPLVKALGKVIASGVPEAERYVHLGATSQDAMDTGLVLQLRD 120
Query 122 ALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRI 181
AL +++ + + +T QA + M+GRTWLQ A P+TLG KLA A R R+
Sbjct 121 ALDLIEADLGKLADTLSQQALKHADTPMVGRTWLQHATPVTLGMKLAGVLGALTRHRQRL 180
Query 182 NAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASVL 241
+ GGA GSLA+L + V EA A+QLKL WH +RDR+VE ASVL
Sbjct 181 QELGPPCWCCSSGGASGSLAALGSKAMPVAEALAEQLKLSLPEQPWHTQRDRLVEFASVL 240
Query 242 GIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPA 301
G++ G++GK RD SL+MQTE EVFEP+A G+GGSSTMPHKRNPV AA ++ AA RVP
Sbjct 241 GLVAGSLGKFGRDVSLLMQTEAGEVFEPSAPGKGGSSTMPHKRNPVGAAVLIGAATRVPG 300
Query 302 LMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIE 361
L+S+++ +M QEHERSLG WHAEW +LP+I L +GAL + + +G+EV+A M +N++
Sbjct 301 LVSTLFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGIEVDAARMRRNLD 360
Query 362 CTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQ 421
T GL++AEAV + LA +GR AHH++E C+ AVAEQ+HL+ ++ +V + +
Sbjct 361 LTQGLVLAEAVSIVLARTLGRDRAHHLLEQCCQRAVAEQRHLRAVLGDDPQVSAELSAEE 420
Query 422 LD 423
LD
Sbjct 421 LD 422
Score = 18.5 bits (36), Expect = 7.9
Identities = 12/35 (34%), Positives = 16/35 (46%), Gaps = 3/35 (9%)
Query 416 YFNPSQLDEIFKPESYLGNIQDQIDAVLQEAKGEA 450
YF + EIF S G +Q +D A+ EA
Sbjct 9 YFTAPAMREIF---SDRGRLQGMLDFEAALARAEA 40
>O42889 Uncharacterized protein C8E4.05c [Schizosaccharomyces
pombe (strain 972 / ATCC 24843)]
Length=447
Score = 327 bits (837), Expect = 3e-111
Identities = 171/443 (39%), Positives = 270/443 (61%), Gaps = 5/443 (1%)
Query 2 SQLYASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAID 61
S ++ ++F ++ +I+SD + E ALA+A+A +G+IP+ A I+R K ++
Sbjct 8 SFVFRNIFGDAEIRKIWSDENRTQEYLNWEAALARAEASLGIIPKYAGEEIQRVCK--VE 65
Query 62 KIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRD 121
IDF L T G + V QL + D+ +Y HWGAT+QD+ D+A + Q D
Sbjct 66 NIDFSKLEEETINIGYPVLGVVHQLANLCSG---DSGKYCHWGATTQDVTDSATVRQMID 122
Query 122 ALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRI 181
+ I++ +++ E A +R M GR+ LQQA+PIT G K+AR+ + +R R+
Sbjct 123 SFKIIKGYLEKAIELATVLVIKHRETTMAGRSNLQQAVPITFGFKMARFVATLRRHHQRL 182
Query 182 NAIKARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASVL 241
+ RV V + GGA G+LASL+++G +V + A++L L Q WH ERDRI E L
Sbjct 183 CELLPRVSVLEFGGACGTLASLENKGLMVQQKLAEELGLLQPEIAWHTERDRIAEAGCFL 242
Query 242 GIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPA 301
G++TG + K A D L+MQTE+AEVFEP RG SSTMP KRNP++ + A+ + V
Sbjct 243 GMLTGTLAKFATDIKLLMQTEVAEVFEPFKANRGSSSTMPQKRNPISCVYITASTSFVRQ 302
Query 302 LMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIE 361
++++ +MV++HER+ GAW EW+ LP++F T G L++T+ +L+G+EV+ M++N+
Sbjct 303 GVAALLDAMVEDHERATGAWEIEWIVLPDVFVHTVGTLKQTVFLLEGLEVHPSRMNENLS 362
Query 362 CTHGLIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQ 421
T+GLI++EAVMMALAP +GR AH +V C ++ E K L +++ +V Y + +
Sbjct 363 ITNGLIVSEAVMMALAPKLGRDEAHDLVYRLCHLSIQENKPLVELLLAERQVTNYLSKEE 422
Query 422 LDEIFKPESYLGNIQDQIDAVLQ 444
+ + PE+YLG+ + I+ LQ
Sbjct 423 VTSLLNPENYLGSTFEMIERALQ 445
>A0A0U2UYC4 Trans-aconitate decarboxylase 1 [Ustilago maydis]
Length=493
Score = 294 bits (753), Expect = 4e-98
Identities = 162/438 (37%), Positives = 247/438 (56%), Gaps = 5/438 (1%)
Query 6 ASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDF 65
+ +F + EI+SD+ V+ +E E ALA QA +G+IP++AA I + + +ID+
Sbjct 55 SDIFGTPQMREIWSDQNRVACYLEIEAALAIVQADLGIIPKNAAHEIVEHCR--VQEIDW 112
Query 66 DALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAI 125
T L G + V+QL A KD Y HWGAT+QDI DTA ++Q R +L +
Sbjct 113 ALYKQKTELIGYPVLGIVQQLVANCKDG---LGEYCHWGATTQDITDTATVMQIRQSLTL 169
Query 126 VQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIK 185
V+ ++ + A+ +R+ M R+ L+QA+PIT G K+AR+ + F+R R+ ++
Sbjct 170 VKQRLDSIVSSLEHLAEQHRNVPMAARSNLKQAVPITFGFKMARFLATFRRHQQRLVELE 229
Query 186 ARVLVAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASVLGIIT 245
RV + GGA G+L+SL DQG +A AK L L WH E DR E+ + LG++T
Sbjct 230 KRVYTLEFGGAAGNLSSLGDQGIATHDALAKMLDLAPAEIAWHTEHDRFAEVGTFLGLLT 289
Query 246 GNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSS 305
G + K+A D LM QTE+ EV EP RG SSTMP K NP++ + A A V ++
Sbjct 290 GTLAKLATDIKLMSQTEVGEVGEPFISNRGSSSTMPQKNNPISCVYIHACAANVRQGAAA 349
Query 306 IYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHG 365
+ +M +HER G W W+ LP + T+ AL VL+G++V + M N++ + G
Sbjct 350 LLDAMQSDHERGTGPWEIIWVQLPLMMNWTSAALNNADFVLRGLQVFPDAMQHNLDLSKG 409
Query 366 LIMAEAVMMALAPHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEI 425
LI++EAVMM L +GR AH V C+TA + + L D++ + E+ + ++L+++
Sbjct 410 LIVSEAVMMGLGNTLGRQYAHDAVYECCRTAFVQDRPLLDVLLENHEIASKLDRTELEKL 469
Query 426 FKPESYLGNIQDQIDAVL 443
P +YLG ID VL
Sbjct 470 CDPANYLGQCSQWIDRVL 487
>Q58339 Adenylosuccinate lyase [Methanocaldococcus jannaschii
(strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)]
Length=462
Score = 233 bits (594), Expect = 8e-75
Identities = 141/442 (32%), Positives = 245/442 (55%), Gaps = 12/442 (3%)
Query 13 DVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATAT 72
++ +++ + + M++ E ALA+AQA++G+IP+ AA I + A T K++
Sbjct 26 EMRKVWEEENKLEKMLKVEAALAKAQAELGLIPKEAAEEINKKASTKYVKLE-----RVK 80
Query 73 GLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQ 132
+ V + A+ + + +A Y+H+GATS DI+DTA L ++++ I++++++Q
Sbjct 81 EIEKQTKHDVVAMIRALAEVCEGNAGEYIHFGATSNDIVDTANSLLIKESIEIIEDKLKQ 140
Query 133 CYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQ 192
+ L +A+ +++ V +GRT Q A+P T G + A WA+ R L+R+ K R+ V+
Sbjct 141 LRDILLDKAEEHKYTVCVGRTHGQHAIPTTYGMRFALWAAEIDRHLERLKEAKKRICVSM 200
Query 193 LGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWHG-ERDRIVEIASVLGIITGNVGKM 251
+ GAVG++A++ ++G V + A+ L L + +RDR E +L +I + K+
Sbjct 201 ITGAVGTMAAMGEKGLEVHKRVAEILGLEPVLISNQVIQRDRHAEFVFLLALIAQTLNKI 260
Query 252 ARDWSLMMQTEIAEV---FEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQ 308
M +TEI E+ F+PT + GSSTMPHKRNP+ + + + +L +
Sbjct 261 GVTVRSMQRTEIGELEEEFDPTK--QTGSSTMPHKRNPITFEQICGLSRVIKSLCIAEMD 318
Query 309 SMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHGLIM 368
++ ER L AE E+ LT L + +K ++VN EN+ +N+E T GLIM
Sbjct 319 NIPLWEERDLTNSSAERCIFAEVCVLTDHILTLAIKGVKKLKVNKENVERNLELTKGLIM 378
Query 369 AEAVMMALAPH-MGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEIFK 427
AE +M+ LA MGR AH +V A E++HLKDI+ + +EV +Y +L+E+
Sbjct 379 AERIMIELAKRGMGRQTAHEIVRQCAMKAYEEKRHLKDILLENEEVMKYITKEELEELMN 438
Query 428 PESYLGNIQDQIDAVLQEAKGE 449
P++Y+G +D V++ K +
Sbjct 439 PKTYIGLAPQIVDEVIKTLKNK 460
>O27580 Adenylosuccinate lyase [Methanothermobacter thermautotrophicus
(strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330
/ Delta H)]
Length=449
Score = 223 bits (569), Expect = 3e-71
Identities = 146/426 (34%), Positives = 230/426 (54%), Gaps = 12/426 (3%)
Query 27 MVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATATGLAGNIAIPFVKQL 86
M++ E ALAQA+ ++G+IP AA+ I R A T +F L + + +
Sbjct 28 MLDVEAALAQAEGELGIIPAEAASEIVRKAST-----EFVTLERVNEIERDTKHDIASLV 82
Query 87 TAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQCYETALSQAQTYRH 146
A+ + + DA YVH+GATS DI+DT+ L RD+++++++++ + E L+ A R
Sbjct 83 KALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRD 142
Query 147 QVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQLGGAVGSLASLQDQ 206
+V +GRT Q ALP T G K A WA R L+R++A R+ V + GAVG+ A+L ++
Sbjct 143 RVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDACSERLCVGMMTGAVGTTAALGEE 202
Query 207 GSIVVEAYAKQLKLGQTACTWH-GERDRIVEIASVLGIITGNVGKMARDWSLMMQTEIAE 265
G V E ++ L L + +RD E VL I + K+A + + +TEI E
Sbjct 203 GLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLANIATTLDKIALEIRNLQRTEIME 262
Query 266 V---FEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQSMVQEHERSLGAWH 322
V F+P + + GSSTMPHK NP+ A + A + + + + ++ HER L
Sbjct 263 VGEKFDP--EKQVGSSTMPHKMNPITAERICGIARVIRSYVVAALENNPLWHERDLTNSS 320
Query 323 AEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHGLIMAEAVMMALAPH-MG 381
+E + LPE LT L+ TLDVL + EN+ +N+E T GLIMAE +M L MG
Sbjct 321 SERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAERLMAELTRRGMG 380
Query 382 RLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEIFKPESYLGNIQDQIDA 441
R A+ V A + L+D++ + E+ Y L+EI PE+Y+G+ + ++
Sbjct 381 RQTAYAAVRQCAIEASRTGRSLRDVVLERSEIMDYLTVEDLEEIMNPETYIGSARRMVER 440
Query 442 VLQEAK 447
VL+E++
Sbjct 441 VLEESQ 446
>Q9UZ99 Adenylosuccinate lyase [Pyrococcus abyssi (strain GE5
/ Orsay)]
Length=450
Score = 210 bits (534), Expect = 4e-66
Identities = 144/441 (33%), Positives = 229/441 (52%), Gaps = 25/441 (6%)
Query 13 DVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATAT 72
++ ++ + + +++ E ALA+A A++G IP+ +A VI A T K++
Sbjct 14 EMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLE-------- 65
Query 73 GLAGNIAIPFVKQLTAIVKDADE---DAARYVHWGATSQDILDTACILQCRDALAIVQNQ 129
I + A+VK E + +YVH GATS DI+DTA L +++LAIV+
Sbjct 66 -RVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
Query 130 VQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVL 189
+++ A+ + V +GRT Q A+P T G K A W +R ++R+ +K RVL
Sbjct 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
Query 190 VAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWH-GERDRIVEIASVLGIITGNV 248
V ++ GAVG+ AS D+ + + + L L T +RD E+ L ++ +
Sbjct 185 VGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTL 244
Query 249 GKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAA-----NRVPALM 303
KMA + + +TEI EV EP + + GSSTMPHKRNP+ V A N +PAL+
Sbjct 245 DKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL 304
Query 304 SSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECT 363
++ HER L E + LPE F L L+ VLKG+E EN+ +N+ T
Sbjct 305 NNPLW-----HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
Query 364 HGLIMAEAVMMALAPH-MGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQL 422
LIMAE +M+ LA MGR AH +V A E + L +++ + +E +Y + L
Sbjct 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
Query 423 DEIFKPESYLGNIQDQIDAVL 443
+ + KPE+Y+G ++ ++ V+
Sbjct 420 EGL-KPENYIGKAREIVENVV 439
>O58582 Adenylosuccinate lyase [Pyrococcus horikoshii (strain
ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)]
Length=450
Score = 209 bits (533), Expect = 5e-66
Identities = 144/442 (33%), Positives = 226/442 (51%), Gaps = 25/442 (6%)
Query 13 DVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATAT 72
++ +I+ ++ + +++ E ALA+A A+VG IP+ +A VI A T K++
Sbjct 14 EMRKIWDEKNKLQKLLDVEAALARAHAKVGNIPEESAKVISERANTKWVKLE-------- 65
Query 73 GLAGNIAIPFVKQLTAIVKDADE---DAARYVHWGATSQDILDTACILQCRDALAIVQNQ 129
I + A+VK E + +YVH GATS DI+DTA L +++L IV+
Sbjct 66 -RVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLEIVERD 124
Query 130 VQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVL 189
+++ A+ + V +GRT Q A+P T G K A W +R ++R+ +K RVL
Sbjct 125 LKELRSILKQLAEKHIGTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLYQLKERVL 184
Query 190 VAQLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWH-GERDRIVEIASVLGIITGNV 248
V ++ GAVG+ AS ++ + + L L T +RD E+ L ++ +
Sbjct 185 VGKMRGAVGTAASFGEKAFEIERLVMEDLGLKPARITNQIVQRDVYAELLFFLALVASTL 244
Query 249 GKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAA-----NRVPALM 303
KM + + +TEI EV EP + + GSSTMPHKRNP+ V A N +PAL+
Sbjct 245 DKMGLEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL 304
Query 304 SSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECT 363
++ HER L E + LPE F L L+ VL G+E EN+ +N+ T
Sbjct 305 NNPLW-----HERDLTNSSVERVILPESFVLLDEMLKTMKKVLTGLEFFPENIRRNLYLT 359
Query 364 HGLIMAEAVMMALAPH-MGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQL 422
LIMAE +M+ LA MGR AH VV A E + L ++ + E+ +Y L
Sbjct 360 KNLIMAEPLMLKLAEKGMGRQEAHEVVRQLAMKAFRENRDLLEVAKESREITKYLTERDL 419
Query 423 DEIFKPESYLGNIQDQIDAVLQ 444
+E+ KPE+Y+G ++ + V++
Sbjct 420 EEL-KPENYIGKAREIVKKVIE 440
>Q7A0G9 Adenylosuccinate lyase [Staphylococcus aureus (strain
MW2)]
Length=431
Score = 183 bits (464), Expect = 4e-56
Identities = 118/441 (27%), Positives = 227/441 (51%), Gaps = 20/441 (5%)
Query 9 FYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDAL 68
+ + +++ I++D+ +E E+ +A +++G IP++ I + AK +++
Sbjct 5 YSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQ 64
Query 69 ATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQN 128
T + + F +Q V + + ++VH+G TS D++DTA + A I++
Sbjct 65 ETRHDV-----VAFTRQ----VSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEK 115
Query 129 QVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARV 188
+++ + +A+ Y++ +MMGRT A P T G K+A W + +R+L R ++ +
Sbjct 116 DLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEI 175
Query 189 LVAQLGGAVGSLASLQDQGSIVVEAYA-KQLKLGQT-ACTWHGERDRIVEIASVLGIITG 246
V ++ GAVG+ A++ + +E+Y K L +G T +RDR + L +I
Sbjct 176 EVGKMSGAVGTFANIPPE----IESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIAT 231
Query 247 NVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSI 306
++ K A + + +TE EV E AKG+ GSS MPHKRNP+ + ++ + + +++
Sbjct 232 SLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTA 291
Query 307 YQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHGL 366
Y+++ HER + AE + LP++ AL R +++ + V +NM NI+ T GL
Sbjct 292 YENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGL 351
Query 367 IMAEAVMMALA-PHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEI 425
I ++ V++AL M R A+ V+ + + +++I Q + + +LDE
Sbjct 352 IFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTKEELDEC 411
Query 426 FKPESYLGNIQDQIDAVLQEA 446
F P+ +L +Q+D + + A
Sbjct 412 FDPKHHL----NQVDTIFERA 428
>P12047 Adenylosuccinate lyase [Bacillus subtilis (strain 168)]
Length=431
Score = 172 bits (435), Expect = 6e-52
Identities = 121/427 (28%), Positives = 215/427 (50%), Gaps = 18/427 (4%)
Query 13 DVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATAT 72
+++ I++D +E E+ +A A++GVIP+ V+ A I++I T
Sbjct 9 EMSAIWTDENRFQAWLEVEILACEAWAELGVIPKEDVKVMRENASFDINRILEIEKDTRH 68
Query 73 GLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQ 132
+ T V ++ + ++VH+G TS D++DTA + A I+ +++
Sbjct 69 DVVA---------FTRAVSESLGEERKWVHYGLTSTDVVDTALSYLLKQANDILLKDLER 119
Query 133 CYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQ 192
+ +A+ +++ VMMGRT A P T G KLA W KR+L+R KA + V +
Sbjct 120 FVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFKQAKAGIEVGK 179
Query 193 LGGAVGSLASLQDQGSIVVEAYAKQLKLGQTAC---TWHGERDRIVEIASVLGIITGNVG 249
+ GAVG+ A++ VE Y + KLG A T +RDR + + L +I ++
Sbjct 180 ISGAVGTYANIDP----FVEQYVCE-KLGLKAAPISTQTLQRDRHADYMATLALIATSIE 234
Query 250 KMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQS 309
K A + + ++E EV E AKG+ GSS MPHKRNP+ + ++ A + M + Y++
Sbjct 235 KFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGYMMTAYEN 294
Query 310 MVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHGLIMA 369
+ HER + AE + LP+ L R +++K + V ENM +N++ T GLI +
Sbjct 295 VPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNLTVFPENMKRNMDRTLGLIYS 354
Query 370 EAVMMALA-PHMGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEIFKP 428
+ V++AL + R A+ V+ A +Q ++++ +++ +P ++ + F
Sbjct 355 QRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFRELVEAEEKITSRLSPEKIADCFDY 414
Query 429 ESYLGNI 435
+L N+
Sbjct 415 NYHLKNV 421
>Q9X0I0 Adenylosuccinate lyase [Thermotoga maritima (strain ATCC
43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)]
Length=431
Score = 164 bits (414), Expect = 6e-49
Identities = 115/422 (27%), Positives = 207/422 (49%), Gaps = 14/422 (3%)
Query 16 EIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATATGLA 75
+++++ A +E E+A+ +A ++G+IP+ V ER A KID +
Sbjct 12 DLWTEEAKYRRWLEVELAVTRAYEELGMIPKG---VTERIRNNA--KIDVELFKKIEEKT 66
Query 76 GNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQCYE 135
+ + FV+ + +++ ED+ R+ H+G TS D+LDTA L +A I+ +++ +
Sbjct 67 NHDVVAFVEGIGSMI---GEDS-RFFHYGLTSSDVLDTANSLALVEAGKILLESLKEFCD 122
Query 136 TALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQLGG 195
A Y+H +GRT A P + G K+ W S KR++ R+ V ++ G
Sbjct 123 VLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKISG 182
Query 196 AVGSLASLQDQGSIVVEAYAKQLKLG-QTACTWHGERDRIVEIASVLGIITGNVGKMARD 254
AVG+ A++ + V E L L + T RDR S L I+ + ++A +
Sbjct 183 AVGNYANVPPE---VEEKALSYLGLKPEPVSTQVVPRDRHAFYLSTLAIVAAGIERIAVE 239
Query 255 WSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQSMVQEH 314
+ +TE+ EV EP KG+ GSS MPHK+NP+ + + + A + +++ H
Sbjct 240 IRHLQRTEVLEVEEPFRKGQRGSSAMPHKKNPITCERLTGLSRMMRAYVDPSLENIALWH 299
Query 315 ERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHGLIMAEAVMM 374
ER + E P+ Q + +V++ M+VN E M +NI+ T GL+ ++ V++
Sbjct 300 ERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDLTKGLVFSQRVLL 359
Query 375 ALAPH-MGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDEIFKPESYLG 433
L + R A+ +V+ +KH + + + +EVK+ +L+E+F YL
Sbjct 360 KLIEKGLTRKEAYDIVQRNALKTWNSEKHFLEYLLEDEEVKKLVTKEELEELFDISYYLK 419
Query 434 NI 435
++
Sbjct 420 HV 421
>P30566 Adenylosuccinate lyase [Homo sapiens]
Length=484
Score = 95.1 bits (235), Expect = 3e-24
Identities = 112/459 (24%), Positives = 199/459 (43%), Gaps = 32/459 (7%)
Query 6 ASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDF 65
AS + ++ +FSDR + + LA+A+ +G +P + + E K+ ++ IDF
Sbjct 18 ASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEM--KSNLENIDF 74
Query 66 DALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAI 125
A + + V A A +H GATS + D ++ R+AL +
Sbjct 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKA----AGIIHLGATSCYVGDNTDLIILRNALDL 130
Query 126 VQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIK 185
+ ++ + A+ +G T Q A T+G + W DL + ++
Sbjct 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190
Query 186 ARVLVAQLGGAVGSLAS-----------LQDQGSIVVEAYAKQLKLGQTACTWHGERDRI 234
+ + G G+ AS ++ +V E + T T+ + D
Sbjct 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD-- 248
Query 235 VEIASVLGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLA 294
+E+ SVL + +V K+ D L+ + E+ EP K + GSS MP+KRNP+ + +
Sbjct 249 IEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCS 306
Query 295 AANRVPAL-MSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTL-DVLKGMEVN 352
A + L M + + VQ ER+L + L E F LTA + TL ++ +G+ V
Sbjct 307 LARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF-LTADTILNTLQNISEGLVVY 365
Query 353 AENMHQNIECTHGLIMAEAVMMALAPHMG-RLNAH---HVVEAACKTAVAEQKHLKDIIS 408
+ + + I + E ++MA+ G R + H V+ + V ++ D+I
Sbjct 366 PKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIE 425
Query 409 QVDEVKQYFNP--SQLDEIFKPESYLGNIQDQIDAVLQE 445
++ +V YF+P SQLD + P S+ G Q+ L+E
Sbjct 426 RI-QVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEE 463
>P54822 Adenylosuccinate lyase [Mus musculus]
Length=484
Score = 94.0 bits (232), Expect = 8e-24
Identities = 111/459 (24%), Positives = 197/459 (43%), Gaps = 32/459 (7%)
Query 6 ASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDF 65
A+ + R++ +FSDR + + LA+A+ +G +P + + E K+ ++ IDF
Sbjct 18 AARYASREMCFLFSDRYKFQTWRQLWLWLAEAEQTLG-LPITDEQIQEM--KSNLNNIDF 74
Query 66 DALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAI 125
A + + V A A +H GATS + D ++ R+A +
Sbjct 75 QMAAEEEKRLRHDVMAHVHTFGHCCPKA----AGIIHLGATSCYVGDNTDLIILRNAFDL 130
Query 126 VQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIK 185
+ ++ + A+ +G T Q A T+G + W DL + ++
Sbjct 131 LLPKLARVISRLADFAKDRADLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190
Query 186 ARVLVAQLGGAVGSLAS-----------LQDQGSIVVEAYAKQLKLGQTACTWHGERDRI 234
+ + G G+ AS ++ +V E + T T+ + D
Sbjct 191 DELRFRGVKGTTGTQASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD-- 248
Query 235 VEIASVLGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLA 294
+E+ SVL + +V K+ D L+ + E+ EP K + GSS MP+KRNP+ + +
Sbjct 249 IEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCS 306
Query 295 AANRVPAL-MSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTL-DVLKGMEVN 352
A + AL M + + VQ ER+L + L E F LTA + TL ++ +G+ V
Sbjct 307 LARHLMALTMDPLQTASVQWFERTLDDSANRRICLAEAF-LTADTILNTLQNISEGLVVY 365
Query 353 AENMHQNIECTHGLIMAEAVMMALAPHMG-RLNAHHVVEAACKTAVAEQKHL---KDIIS 408
+ + + I + E ++MA+ G R + H + + A A K D+I
Sbjct 366 PKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIE 425
Query 409 QVDEVKQYFNP--SQLDEIFKPESYLGNIQDQIDAVLQE 445
++ YF+P SQL+ + P S+ G Q+ L+E
Sbjct 426 RI-RADAYFSPIHSQLEHLLDPSSFTGRAPQQVHRFLEE 463
>P21265 Adenylosuccinate lyase [Gallus gallus]
Length=485
Score = 88.6 bits (218), Expect = 5e-22
Identities = 108/447 (24%), Positives = 185/447 (41%), Gaps = 32/447 (7%)
Query 18 FSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAIDKIDFDALATATGLAGN 77
FS+R + LAQA+ +G +P + + E A +D IDF A +
Sbjct 31 FSERKKFGTWRRLWLYLAQAEKSLG-LPITDEQIKEMEAN--LDNIDFKMAAEEEKKLRH 87
Query 78 IAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQCYETA 137
+ V A A +H GATS + D ++ RD ++ ++ +
Sbjct 88 DVMAHVHTFAHCCPKA----AAIIHLGATSCYVGDNTDLIVLRDGFNLLLPKLARVISRL 143
Query 138 LSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQLGGAV 197
A+T+ +G T Q A T+G + W DL + + + + G
Sbjct 144 ADFAETHADLPTLGFTHYQPAQLTTVGKRCCLWIQDLCMDLQNLERARDDLRFRGVKGTT 203
Query 198 GSLAS-----------LQDQGSIVVEAYAKQLKLGQTACTWHGERDRIVEIASVLGIITG 246
G+ AS +++ +V + T T+ + D +E+ SVL +
Sbjct 204 GTQASFLQLFEGDHSKVEELDRLVTAKAGFKRSYMVTGQTYSRKVD--IEVLSVLASLGA 261
Query 247 NVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPAL-MSS 305
+V K+ D L+ + E+ EP K + GSS MP+KRNP+ + + A + L +
Sbjct 262 SVHKICTDIRLL--ANLKEIEEPFEKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDP 319
Query 306 IYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTL-DVLKGMEVNAENMHQNIECTH 364
+ + VQ ER+L + L E F LTA + TL ++ +G+ V + + + I
Sbjct 320 LQTASVQWFERTLDDSANRRVCLAEAF-LTADIILSTLQNISEGLVVYPKVIDRRIRQEL 378
Query 365 GLIMAEAVMMALAPHMG-RLNAHHVVEAACKTAVAEQKHL---KDIISQVDEVKQYFNP- 419
+ E ++MA+ G R + H + + A A K D I++V YF+P
Sbjct 379 PFMATENIIMAMVKAGGNRQDCHEKIRVLSQQAAAVVKQEGGDNDFIARV-RADPYFSPI 437
Query 420 -SQLDEIFKPESYLGNIQDQIDAVLQE 445
LD + P S+ G Q+ L+E
Sbjct 438 HEHLDSLLDPSSFTGRAPQQVAKFLKE 464
>P39461 Fumarate hydratase class II [Saccharolobus solfataricus
(strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)]
Length=438
Score = 87.0 bits (214), Expect = 1e-21
Identities = 94/366 (26%), Positives = 175/366 (48%), Gaps = 22/366 (6%)
Query 21 RALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAID-----KIDFDALATATGLA 75
R ++ M + + A+ A +G++ + A I +A+ ID KI D T +G
Sbjct 20 RRIIWSMGVLKKSCAKVNADLGLLDKKIADSIIKASDDLIDGKLDDKIVLDVFQTGSGTG 79
Query 76 GNIAI-PFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQV---- 130
N+ + + ++ + + +V++G +S D + TA + A+A V N++
Sbjct 80 LNMNVNEVIAEVASSYSNLKVHPNDHVNFGQSSNDTVPTAIRIA---AVAEVTNRLLPAL 136
Query 131 QQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLV 190
QQ + +A+ Y+ + GRT L+ ALP+TLG +L+ +A AF+ + +++ I V
Sbjct 137 QQIISSLNKKAEEYKDVIKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKE 196
Query 191 AQLGG-AVGS-LASLQDQGSIVVEAYAKQLKLG-QTACTWHGER--DRIVEIASVLGIIT 245
+GG A G+ L S + V+ + LG + A + R ++ ++ L I
Sbjct 197 LPIGGTATGTGLNSHPEFQERVINEINRITGLGFKPANRFRAMRLLTDLLLLSGALRNIA 256
Query 246 GNVGKMARDWSLMMQ---TEIAEVFEPTAKGRGGSSTMPHKRNPVAA-ASVLAAANRVPA 301
++ ++ +D LM T + E+ PT + GSS MP K NPV A++L +A V
Sbjct 257 VDLYRLGQDIRLMFSGPLTGLNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLISAQVVGL 316
Query 302 LMSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIE 361
++ + SM+ E E S+G + + ++ ++ + + V+ GM N E M + E
Sbjct 317 DHANQFASMLGEFELSMGIPLVGYNIVTQVNFISEALEKMSRLVIDGMVANVEKMKRYAE 376
Query 362 CTHGLI 367
+ LI
Sbjct 377 SSPSLI 382
Lambda K H a alpha
0.320 0.130 0.375 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 2733600
Database: 02477935e68713be1869007a42485f71.SwissProt.fasta
Posted date: May 9, 2024 9:25 AM
Number of letters in database: 7,718
Number of sequences in database: 17
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
