Comparative Genomics

ACIAD1728 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 8bdcceda742bc6f9da819ad16a2efc66.SwissProt.fasta
           14 sequences; 2,113 total letters



Query= ACIAD1728

Length=160
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P9WME8 HTH-type transcriptional repressor MT2955 [Mycobacterium t...  62.4    8e-17
P67748 HTH-type transcriptional repressor Mb2911 [Mycobacterium b...  62.4    8e-17
P9WME9 HTH-type transcriptional repressor Rv2887 [Mycobacterium t...  62.4    8e-17
P67746 Uncharacterized HTH-type transcriptional regulator Mb0904 ...  58.9    2e-15
P9WMF1 HTH-type transcriptional regulator Rv0880 [Mycobacterium t...  58.9    2e-15
P9WMF0 HTH-type transcriptional regulator MT0903.1 [Mycobacterium...  58.9    2e-15
O33060 Uncharacterized HTH-type transcriptional regulator ML2140 ...  56.6    1e-14
P0A2T5 Multiple antibiotic resistance protein MarR [Salmonella ty...  55.5    4e-14
P0A2T4 Multiple antibiotic resistance protein MarR [Salmonella ty...  55.5    4e-14
P27245 Multiple antibiotic resistance protein MarR [Escherichia c...  54.3    1e-13
Q9HJA6 Riboflavin kinase [Thermoplasma acidophilum (strain ATCC 2...  32.7    1e-05


>P9WME8 HTH-type transcriptional repressor MT2955 [Mycobacterium 
tuberculosis (strain CDC 1551 / Oshkosh)]
Length=139

 Score = 62.4 bits (150),  Expect = 8e-17
 Identities = 33/114 (29%), Positives = 63/114 (55%), Gaps = 0/114 (0%)

Query  13   EEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQ  72
            ++  L Y++ RV  ++   ++  LS L ++LP+F  L +L+  P LS+A+LA  + + PQ
Sbjct  5    DDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQ  64

Query  73   SANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQML  126
            + N +L+ L   G + +    + GR +  T+T  G     +   VV+  +A++L
Sbjct  65   AMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVL  118


>P67748 HTH-type transcriptional repressor Mb2911 [Mycobacterium 
bovis (strain ATCC BAA-935 / AF2122/97)]
Length=139

 Score = 62.4 bits (150),  Expect = 8e-17
 Identities = 33/114 (29%), Positives = 63/114 (55%), Gaps = 0/114 (0%)

Query  13   EEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQ  72
            ++  L Y++ RV  ++   ++  LS L ++LP+F  L +L+  P LS+A+LA  + + PQ
Sbjct  5    DDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQ  64

Query  73   SANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQML  126
            + N +L+ L   G + +    + GR +  T+T  G     +   VV+  +A++L
Sbjct  65   AMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVL  118


>P9WME9 HTH-type transcriptional repressor Rv2887 [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=139

 Score = 62.4 bits (150),  Expect = 8e-17
 Identities = 33/114 (29%), Positives = 63/114 (55%), Gaps = 0/114 (0%)

Query  13   EEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQ  72
            ++  L Y++ RV  ++   ++  LS L ++LP+F  L +L+  P LS+A+LA  + + PQ
Sbjct  5    DDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQ  64

Query  73   SANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQML  126
            + N +L+ L   G + +    + GR +  T+T  G     +   VV+  +A++L
Sbjct  65   AMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVL  118


>P67746 Uncharacterized HTH-type transcriptional regulator Mb0904 
[Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)]
Length=143

 Score = 58.9 bits (141),  Expect = 2e-15
 Identities = 34/134 (25%), Positives = 74/134 (55%), Gaps = 0/134 (0%)

Query  12   EEEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKP  71
            + + RL+  ++     +S+ L     +  +SL Q +AL+ LA +  ++   LA R  ++P
Sbjct  3    DSDARLASDLSLAVMRLSRQLRFRNPSSPVSLSQLSALTTLANEGAMTPGALAIRERVRP  62

Query  72   QSANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQMLQGVDI  131
             S  +++  L   G++++AP P  GR++LV+V+ SG + +    +  Q+  A+ L  ++ 
Sbjct  63   PSMTRVIASLADMGFVDRAPHPIDGRQVLVSVSESGAELVKAARRARQEWLAERLATLNR  122

Query  132  NLAFLIRNNLELMV  145
            +   ++R+  +LM+
Sbjct  123  SERDILRSAADLML  136


>P9WMF1 HTH-type transcriptional regulator Rv0880 [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=143

 Score = 58.9 bits (141),  Expect = 2e-15
 Identities = 34/134 (25%), Positives = 74/134 (55%), Gaps = 0/134 (0%)

Query  12   EEEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKP  71
            + + RL+  ++     +S+ L     +  +SL Q +AL+ LA +  ++   LA R  ++P
Sbjct  3    DSDARLASDLSLAVMRLSRQLRFRNPSSPVSLSQLSALTTLANEGAMTPGALAIRERVRP  62

Query  72   QSANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQMLQGVDI  131
             S  +++  L   G++++AP P  GR++LV+V+ SG + +    +  Q+  A+ L  ++ 
Sbjct  63   PSMTRVIASLADMGFVDRAPHPIDGRQVLVSVSESGAELVKAARRARQEWLAERLATLNR  122

Query  132  NLAFLIRNNLELMV  145
            +   ++R+  +LM+
Sbjct  123  SERDILRSAADLML  136


>P9WMF0 HTH-type transcriptional regulator MT0903.1 [Mycobacterium 
tuberculosis (strain CDC 1551 / Oshkosh)]
Length=143

 Score = 58.9 bits (141),  Expect = 2e-15
 Identities = 34/134 (25%), Positives = 74/134 (55%), Gaps = 0/134 (0%)

Query  12   EEEPRLSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKP  71
            + + RL+  ++     +S+ L     +  +SL Q +AL+ LA +  ++   LA R  ++P
Sbjct  3    DSDARLASDLSLAVMRLSRQLRFRNPSSPVSLSQLSALTTLANEGAMTPGALAIRERVRP  62

Query  72   QSANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQLEAQMLQGVDI  131
             S  +++  L   G++++AP P  GR++LV+V+ SG + +    +  Q+  A+ L  ++ 
Sbjct  63   PSMTRVIASLADMGFVDRAPHPIDGRQVLVSVSESGAELVKAARRARQEWLAERLATLNR  122

Query  132  NLAFLIRNNLELMV  145
            +   ++R+  +LM+
Sbjct  123  SERDILRSAADLML  136


>O33060 Uncharacterized HTH-type transcriptional regulator ML2140 
[Mycobacterium leprae (strain TN)]
Length=143

 Score = 56.6 bits (135),  Expect = 1e-14
 Identities = 28/106 (26%), Positives = 61/106 (58%), Gaps = 0/106 (0%)

Query  41   ISLPQFTALSVLAAKPNLSNAKLAERSFIKPQSANKILQDLLANGWIEKAPDPTHGRRIL  100
            +SL Q +AL+ LA +  ++   LA R  ++P S  +++  L   G++++ P P  GR++L
Sbjct  32   VSLSQLSALTTLANEGAMTPGALAIRERVRPPSMTRVIASLADMGFVDREPHPVDGRQVL  91

Query  101  VTVTPSGLDKLNQCNQVVQQLEAQMLQGVDINLAFLIRNNLELMVK  146
            V+V+ SG + +    +  Q+   + L  ++ +   ++RN  +L+++
Sbjct  92   VSVSQSGAELVKAARRARQEWLVERLMTLNSDKRDILRNAADLILE  137


>P0A2T5 Multiple antibiotic resistance protein MarR [Salmonella 
typhi]
Length=144

 Score = 55.5 bits (132),  Expect = 4e-14
 Identities = 33/102 (32%), Positives = 54/102 (53%), Gaps = 5/102 (5%)

Query  16   RLSYMI-ARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQSA  74
            RL YM+  + DR+++ YL    S L+I+  QF  L  +     ++  +L +   +   + 
Sbjct  16   RLIYMVNQKKDRLLNNYL----SPLDITATQFKVLCSIRCAGCITPVELKKVLSVDLGAL  71

Query  75   NKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQ  116
             ++L  LL  GWIE+ P+P   R +LV +TP G     QC+Q
Sbjct  72   TRMLDRLLCKGWIERLPNPNDKRGVLVKLTPDGAAICEQCHQ  113


>P0A2T4 Multiple antibiotic resistance protein MarR [Salmonella 
typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=144

 Score = 55.5 bits (132),  Expect = 4e-14
 Identities = 33/102 (32%), Positives = 54/102 (53%), Gaps = 5/102 (5%)

Query  16   RLSYMI-ARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQSA  74
            RL YM+  + DR+++ YL    S L+I+  QF  L  +     ++  +L +   +   + 
Sbjct  16   RLIYMVNQKKDRLLNNYL----SPLDITATQFKVLCSIRCAGCITPVELKKVLSVDLGAL  71

Query  75   NKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQ  116
             ++L  LL  GWIE+ P+P   R +LV +TP G     QC+Q
Sbjct  72   TRMLDRLLCKGWIERLPNPNDKRGVLVKLTPDGAAICEQCHQ  113


>P27245 Multiple antibiotic resistance protein MarR [Escherichia 
coli (strain K12)]
Length=144

 Score = 54.3 bits (129),  Expect = 1e-13
 Identities = 30/104 (29%), Positives = 54/104 (52%), Gaps = 0/104 (0%)

Query  17   LSYMIARVDRIISKYLTEHLSALEISLPQFTALSVLAAKPNLSNAKLAERSFIKPQSANK  76
            L  +I  V++   + L E+LS L+I+  QF  L  +     ++  +L +   +   +  +
Sbjct  14   LGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTR  73

Query  77   ILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKLNQCNQVVQQ  120
            +L  L+  GW+E+ P+P   R +LV +T  G     QC+Q+V Q
Sbjct  74   MLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQ  117


>Q9HJA6 Riboflavin kinase [Thermoplasma acidophilum (strain ATCC 
25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)]
Length=220

 Score = 32.7 bits (73),  Expect = 1e-05
 Identities = 20/54 (37%), Positives = 32/54 (59%), Gaps = 3/54 (6%)

Query  58   LSNAKLAERSFIKPQSANKILQDLLANGWIEKAPDPTHGRRILVTVTPSGLDKL  111
            L+++KLA+   I  QSA++I+ DL  NG+I +       R  ++ +T  GLD L
Sbjct  26   LTSSKLADMLGISQQSASRIIIDLEKNGYITRT---VTKRGQILNITEKGLDVL  76



Lambda      K        H        a         alpha
   0.320    0.133    0.364    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 206262


  Database: 8bdcceda742bc6f9da819ad16a2efc66.SwissProt.fasta
    Posted date:  May 20, 2024  12:58 PM
  Number of letters in database: 2,113
  Number of sequences in database:  14



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40