BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 457804fc88e28a3a30a26c8c265ba3b3.SwissProt.fasta
           15 sequences; 5,378 total letters



Query= ACIAD1878

Length=352
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P00888 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive...  321     5e-112
P0A1B6 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive...  318     6e-111
P0A1B5 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive...  318     6e-111
Q09755 Putative phospho-2-dehydro-3-deoxyheptonate aldolase [Schi...  304     3e-105
P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhi...  296     5e-102
P0AB92 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive...  292     9e-101
P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive...  292     9e-101
O54459 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive...  292     1e-100
C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16 [Alterna...  291     5e-100
P59736 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive...  290     9e-100
P00887 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive...  290     9e-100
Q8X5W4 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive...  288     3e-99 
P35170 Phospho-2-dehydro-3-deoxyheptonate aldolase [Corynebacteri...  287     2e-98 
P79023 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhi...  285     8e-98 
P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine...  281     4e-96 


>P00888 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive 
[Escherichia coli (strain K12)]
Length=356

 Score = 321 bits (823),  Expect = 5e-112
 Identities = 163/348 (47%), Positives = 238/348 (68%), Gaps = 11/348 (3%)

Query  2    NALNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTG  61
            +ALN +   + T E  L  P+QLKA + L+     QIA+ R++I +I+AG+D RLLVV G
Sbjct  4    DALNNV---HITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCG  60

Query  62   PCSIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDL  121
            PCSIHDP +AL+YA+R   L  +V D ++LVMR Y EKPRTT+GWKG + DP++DGS D+
Sbjct  61   PCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDV  120

Query  122  QLGLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHM  181
            + GL+ +R L L+++ MGLP+A+E L P +  Y  DL +W AIGART+ESQ HRE++S +
Sbjct  121  EAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGL  180

Query  182  PFPIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDG  241
              P+GFKNGTDGS+  A++A+++A   H+F+G++Q GQ A+LQ+ GNP  H+ILRG    
Sbjct  181  SMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGK-A  239

Query  242  PNYDIQSISNI--RAKHKGELPALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD--VRG  297
            PNY    ++      +  G  P+L++DCSHGNS+KD  +QP V   ++A+  + +  + G
Sbjct  240  PNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIG  299

Query  298  VMLESHLVDGNQKIS---CDITYGQSVTDGCLGWEKTENLLLEMADQL  342
            +M+ES++ +GNQ       ++ YG SVTD C+ WE T+ LL E+   L
Sbjct  300  LMIESNIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHQDL  347


>P0A1B6 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive 
[Salmonella typhi]
Length=356

 Score = 318 bits (816),  Expect = 6e-111
 Identities = 162/349 (46%), Positives = 236/349 (68%), Gaps = 11/349 (3%)

Query  2    NALNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTG  61
            +ALN +     T E  L  P+QLKA + L+     QIA+ R  I +I+AG+D RLLVV G
Sbjct  4    DALNNV---RITDEQVLMTPEQLKAAFPLSLAQEAQIAQSRGIISDIIAGRDPRLLVVCG  60

Query  62   PCSIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDL  121
            PCSIHDP +AL+YA+R   L  +V D ++LVMR Y EKPRTT+GWKG + DP++DGS D+
Sbjct  61   PCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDV  120

Query  122  QLGLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHM  181
            + GL+ +R L ++++ MGLP+A+E L P +  Y  DL +W AIGART+ESQ HRE++S +
Sbjct  121  EAGLKIARQLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGL  180

Query  182  PFPIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDG  241
              P+GFKNGTDGS+  A++A+++A   H+F+G++Q GQ A+LQ+ GNP  H+ILRG    
Sbjct  181  SMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPHGHVILRGGK-A  239

Query  242  PNYDIQSISNI--RAKHKGELPALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD--VRG  297
            PNY    ++      +  G  P+L++DCSHGNS+KD  +QP V   ++A+  + +  + G
Sbjct  240  PNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIG  299

Query  298  VMLESHLVDGNQKIS---CDITYGQSVTDGCLGWEKTENLLLEMADQLA  343
            +M+ES++ +GNQ       ++ YG SVTD C+ WE T+ LL E+   L+
Sbjct  300  LMIESNIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHKDLS  348


>P0A1B5 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive 
[Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=356

 Score = 318 bits (816),  Expect = 6e-111
 Identities = 162/349 (46%), Positives = 236/349 (68%), Gaps = 11/349 (3%)

Query  2    NALNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTG  61
            +ALN +     T E  L  P+QLKA + L+     QIA+ R  I +I+AG+D RLLVV G
Sbjct  4    DALNNV---RITDEQVLMTPEQLKAAFPLSLAQEAQIAQSRGIISDIIAGRDPRLLVVCG  60

Query  62   PCSIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDL  121
            PCSIHDP +AL+YA+R   L  +V D ++LVMR Y EKPRTT+GWKG + DP++DGS D+
Sbjct  61   PCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDV  120

Query  122  QLGLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHM  181
            + GL+ +R L ++++ MGLP+A+E L P +  Y  DL +W AIGART+ESQ HRE++S +
Sbjct  121  EAGLKIARQLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGL  180

Query  182  PFPIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDG  241
              P+GFKNGTDGS+  A++A+++A   H+F+G++Q GQ A+LQ+ GNP  H+ILRG    
Sbjct  181  SMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPHGHVILRGGK-A  239

Query  242  PNYDIQSISNI--RAKHKGELPALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD--VRG  297
            PNY    ++      +  G  P+L++DCSHGNS+KD  +QP V   ++A+  + +  + G
Sbjct  240  PNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIG  299

Query  298  VMLESHLVDGNQKIS---CDITYGQSVTDGCLGWEKTENLLLEMADQLA  343
            +M+ES++ +GNQ       ++ YG SVTD C+ WE T+ LL E+   L+
Sbjct  300  LMIESNIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHKDLS  348


>Q09755 Putative phospho-2-dehydro-3-deoxyheptonate aldolase [Schizosaccharomyces 
pombe (strain 972 / ATCC 24843)]
Length=368

 Score = 304 bits (779),  Expect = 3e-105
 Identities = 151/328 (46%), Positives = 229/328 (70%), Gaps = 10/328 (3%)

Query  21   PQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPCSIHDPVSALQYAQRLVK  80
            P  ++++ + +   L  +++ R+   +I+AG+D RLL++ GPCS+HDPV+A +YA RL K
Sbjct  33   PALIQSELAASDETLAFVSDQRRQAADIIAGRDDRLLLIVGPCSLHDPVAAKEYAIRLQK  92

Query  81   LQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQIIEMGL  140
               + K  + ++MRAYLEKPRTT+GWKG + DP+LDGS ++  G+  +R ++L+++E G+
Sbjct  93   EAIKHKKDLHIIMRAYLEKPRTTVGWKGLINDPDLDGSYNINKGIRVARRIFLELLETGV  152

Query  141  PIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSIQIALD  200
             IASE+L  ++  Y  DL+ WGAIGART+ESQ+HRE++S + FPIGFKN TDG+I IA+D
Sbjct  153  GIASEMLDTISPQYLADLICWGAIGARTTESQLHRELASGLSFPIGFKNATDGNIGIAID  212

Query  201  AIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIRAKHK--G  258
            A+ S+ N H FL +++ G  AI+ ++GNP  H+ILRG   G N+D  S++  +AK +   
Sbjct  213  AMNSSANPHHFLSVTKQGVVAIVTTTGNPDTHIILRGGKSGTNFDADSVAGAKAKLEECN  272

Query  259  ELPALVIDCSHGNSSKDPMKQPQVLRQIIAERI---ESDVRGVMLESHLVDGNQKISCD-  314
            +LP+++IDCSHGNSSK+   QP+V    IAE++   +  + GVM+ESHL +G Q I  D 
Sbjct  273  KLPSIMIDCSHGNSSKNHKNQPKV-AACIAEQVANGQKAITGVMIESHLNEGKQAIPEDD  331

Query  315  ---ITYGQSVTDGCLGWEKTENLLLEMA  339
               + YG SVTD C+GW+ T  +  ++A
Sbjct  332  LSSMKYGVSVTDACIGWDDTTAVFEQLA  359


>P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited 
[Saccharomyces cerevisiae (strain ATCC 204508 / S288c)]
Length=370

 Score = 296 bits (758),  Expect = 5e-102
 Identities = 147/334 (44%), Positives = 226/334 (68%), Gaps = 8/334 (2%)

Query  18   LSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPCSIHDPVSALQYAQR  77
            L+ P  L+ +    P  LE     R+   +I+ GKD R+LV+ GPCSIHD  +A +YA R
Sbjct  31   LASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDRVLVIVGPCSIHDLEAAQEYALR  90

Query  78   LVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQIIE  137
            L KL D++K  + ++MRAYLEKPRTT+GWKG + DP+++ + ++  GL+ +R L++ +  
Sbjct  91   LKKLSDELKGDLSIIMRAYLEKPRTTVGWKGLINDPDVNNTFNINKGLQSARQLFVNLTN  150

Query  138  MGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSIQI  197
            +GLPI SE+L  ++  Y  DL+++GAIGART+ESQ+HRE++S + FP+GFKNGTDG++ +
Sbjct  151  IGLPIGSEMLDTISPQYLADLVSFGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNV  210

Query  198  ALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIRAKHK  257
            A+DA Q+A + H F+G+++ G  AI  + GN    +ILRG   G NYD +S++  +A+  
Sbjct  211  AVDACQAAAHSHHFMGVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQLP  270

Query  258  GELPALVIDCSHGNSSKDPMKQPQVLRQIIAERI---ESDVRGVMLESHLVDGNQKISCD  314
                 L+ID SHGNS+KD   QP+V   ++ E+I   E+ + GVM+ES++ +GNQ I  +
Sbjct  271  AGSNGLMIDYSHGNSNKDFRNQPKV-NDVVCEQIANGENAITGVMIESNINEGNQGIPAE  329

Query  315  ----ITYGQSVTDGCLGWEKTENLLLEMADQLAQ  344
                + YG S+TD C+GWE TE++L ++A  + Q
Sbjct  330  GKAGLKYGVSITDACIGWETTEDVLRKLAAAVRQ  363


 Score = 21.9 bits (45),  Expect = 0.33
 Identities = 9/22 (41%), Positives = 13/22 (59%), Gaps = 0/22 (0%)

Query  203  QSAQNEHQFLGMSQLGQPAILQ  224
            Q A+ + + LG   L  PA+LQ
Sbjct  17   QGAEEDVRILGYDPLASPALLQ  38


>P0AB92 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive 
[Escherichia coli O157:H7]
Length=350

 Score = 292 bits (748),  Expect = 9e-101
 Identities = 158/346 (46%), Positives = 223/346 (64%), Gaps = 9/346 (3%)

Query  1    MNALNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVT  60
            MN  N  ++    KE  L  P  L  K+         +A  R+ I  IL G D RLLVV 
Sbjct  1    MNYQNDDLRIKEIKE--LLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVI  58

Query  61   GPCSIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSD  120
            GPCSIHDPV+A +YA RL+ L++++KD++ +VMR Y EKPRTT+GWKG + DP++D S  
Sbjct  59   GPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQ  118

Query  121  LQLGLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSH  180
            +  GL  +R L L I + GLP A E L  +   Y  DL++WGAIGART+ESQ+HRE++S 
Sbjct  119  INDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASG  178

Query  181  MPFPIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGAND  240
            +  P+GFKNGTDG+I++A+DAI +A   H FL +++ G  AI+ +SGN   H+ILRG  +
Sbjct  179  LSCPVGFKNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKE  238

Query  241  GPNYDIQSISNIR-AKHKGELPA-LVIDCSHGNSSKDPMKQPQVLRQIIAERI--ESDVR  296
             PNY  + ++ ++   +K  LPA ++ID SH NSSK   KQ  V   +  +    E  + 
Sbjct  239  -PNYSAKHVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAII  297

Query  297  GVMLESHLVDGNQKISC--DITYGQSVTDGCLGWEKTENLLLEMAD  340
            GVM+ESHLV+GNQ +     + YG+S+TD C+GWE T+ LL ++A+
Sbjct  298  GVMVESHLVEGNQSLESGEPLAYGKSITDACIGWEDTDALLRQLAN  343


>P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive 
[Escherichia coli (strain K12)]
Length=350

 Score = 292 bits (748),  Expect = 9e-101
 Identities = 158/346 (46%), Positives = 223/346 (64%), Gaps = 9/346 (3%)

Query  1    MNALNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVT  60
            MN  N  ++    KE  L  P  L  K+         +A  R+ I  IL G D RLLVV 
Sbjct  1    MNYQNDDLRIKEIKE--LLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVI  58

Query  61   GPCSIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSD  120
            GPCSIHDPV+A +YA RL+ L++++KD++ +VMR Y EKPRTT+GWKG + DP++D S  
Sbjct  59   GPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQ  118

Query  121  LQLGLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSH  180
            +  GL  +R L L I + GLP A E L  +   Y  DL++WGAIGART+ESQ+HRE++S 
Sbjct  119  INDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASG  178

Query  181  MPFPIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGAND  240
            +  P+GFKNGTDG+I++A+DAI +A   H FL +++ G  AI+ +SGN   H+ILRG  +
Sbjct  179  LSCPVGFKNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKE  238

Query  241  GPNYDIQSISNIR-AKHKGELPA-LVIDCSHGNSSKDPMKQPQVLRQIIAERI--ESDVR  296
             PNY  + ++ ++   +K  LPA ++ID SH NSSK   KQ  V   +  +    E  + 
Sbjct  239  -PNYSAKHVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAII  297

Query  297  GVMLESHLVDGNQKISC--DITYGQSVTDGCLGWEKTENLLLEMAD  340
            GVM+ESHLV+GNQ +     + YG+S+TD C+GWE T+ LL ++A+
Sbjct  298  GVMVESHLVEGNQSLESGEPLAYGKSITDACIGWEDTDALLRQLAN  343


>O54459 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive 
[Enterobacter agglomerans]
Length=348

 Score = 292 bits (747),  Expect = 1e-100
 Identities = 157/347 (45%), Positives = 228/347 (66%), Gaps = 9/347 (3%)

Query  4    LNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPC  63
            +N   +  T +  +L  P  L A++ ++P   + +   R+ I  IL G+D RLLVV GPC
Sbjct  1    MNKTDELRTARIGSLITPPSLAAEHPVSPAIADNVTAARKRIACILTGEDHRLLVVIGPC  60

Query  64   SIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQL  123
            S+HDP +AL+YA+RL  L+ + +D++ +VMRAY EKPRT +GWKG + DP+LDGS D+  
Sbjct  61   SLHDPKAALEYAERLNALRRRYEDRLEIVMRAYFEKPRTVVGWKGLISDPDLDGSYDVNR  120

Query  124  GLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPF  183
            G+  +R L + I  +GLP A+E L  +   +  DL++WGAIGART+ESQIHRE++S +  
Sbjct  121  GIGIARQLLIDINALGLPTATEFLDMVIGQFIADLISWGAIGARTTESQIHREMASALSC  180

Query  184  PIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPN  243
            P+GFKNGTDG++QIA+DAI++A+  H FL   +LGQ  I Q+SGNP  H+ILRG    PN
Sbjct  181  PVGFKNGTDGNVQIAVDAIRAARASHMFLSPDKLGQMTIYQTSGNPHGHVILRGGKQ-PN  239

Query  244  YDIQSISNIRAKHKG-ELP-ALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD---VRGV  298
            Y    ++          LP  LVID SHGN  K   +Q  V  + +AE+I++    V GV
Sbjct  240  YHASDVAAAAESLSAFNLPQQLVIDFSHGNCLKQHRRQMDVAAE-VAEQIKAGSQAVAGV  298

Query  299  MLESHLVDGNQKISC--DITYGQSVTDGCLGWEKTENLLLEMADQLA  343
            M+ES L +GNQK+     + YG+S+TD CLGW+++E +L  +A+ ++
Sbjct  299  MIESFLEEGNQKVVSGEPLVYGKSITDPCLGWQESEKVLALLAEAVS  345


 Score = 19.6 bits (39),  Expect = 1.8
 Identities = 14/39 (36%), Positives = 21/39 (54%), Gaps = 6/39 (15%)

Query  314  DITYGQSVTD----GCLGWEKTENLL-LEMADQLAQCPL  347
            D+  GQ + D    G +G   TE+ +  EMA  L+ CP+
Sbjct  145  DMVIGQFIADLISWGAIGARTTESQIHREMASALS-CPV  182


>C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16 [Alternaria 
alternata]
Length=374

 Score = 291 bits (745),  Expect = 5e-100
 Identities = 153/338 (45%), Positives = 225/338 (67%), Gaps = 12/338 (4%)

Query  18   LSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDS--RLLVVTGPCSIHDPVSALQYA  75
            L+ P  L+++        + + + R+ +  I   KD+  RLLVV GPCSIHDP++AL+Y 
Sbjct  27   LTPPNLLQSEIPQTAKSRDTVFKAREEVIAIFQNKDAQKRLLVVIGPCSIHDPLAALEYC  86

Query  76   QRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQI  135
             RL+KL+++ +D + +VMR+YLEKPRTTIGWKG + DP++D S  +  GL  SR L+  +
Sbjct  87   DRLMKLKEKYQDDLLIVMRSYLEKPRTTIGWKGLINDPDIDNSFKINKGLRISRQLFADL  146

Query  136  IEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSI  195
             E G+P+ASE+L  ++  +  D+ + G IGART+ESQ+HRE++S + FP+GFKNGTDG++
Sbjct  147  TEKGMPLASEMLDTISPQFLADMFSVGVIGARTTESQLHRELASGLSFPVGFKNGTDGTL  206

Query  196  QIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIRAK  255
             +A+DAI SA+  H FL +++ G  AI+ + GN    +ILRG   G NYD +SI   R K
Sbjct  207  DVAIDAIDSAKYPHHFLSVTKPGVVAIVGTIGNHDCFIILRGGRKGTNYDAKSIKEAREK  266

Query  256  --HKGELPALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD---VRGVMLESHLVDGNQK  310
               +G  P L+IDCSHGNS K+ M QP+V+   +AE+IE+    V GVM+ES+L  G QK
Sbjct  267  LESEGMNPRLMIDCSHGNSEKNHMNQPKVV-HAVAEQIEAGETAVIGVMIESNLKAGTQK  325

Query  311  I----SCDITYGQSVTDGCLGWEKTENLLLEMADQLAQ  344
            +       + YG S+TD C+ W+ TE +L E+A  +A+
Sbjct  326  VPKEGKAGLEYGMSITDACIDWKTTETVLAELAGAVAK  363


>P59736 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive 
[Shigella flexneri]
Length=348

 Score = 290 bits (741),  Expect = 9e-100
 Identities = 153/342 (45%), Positives = 221/342 (65%), Gaps = 7/342 (2%)

Query  4    LNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPC  63
            +N   +  T +  +L  P +L  +Y + P     + + R+ I+ IL G+D RLLV+ GPC
Sbjct  1    MNRTDELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKRLLVIIGPC  60

Query  64   SIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQL  123
            SIHD  +A++YA RL  L++Q + ++ +VMR Y EKPRT +GWKG + DP+L+GS  +  
Sbjct  61   SIHDLTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRVNH  120

Query  124  GLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPF  183
            GLE +R L LQ+ E+G+P A+E L  +   +  DL++WGAIGART+ESQIHRE++S +  
Sbjct  121  GLELARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSC  180

Query  184  PIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPN  243
            P+GFKNGTDG+ +IA+DAI++A+  H FL   + GQ  I Q+SGNP  H+I+RG    PN
Sbjct  181  PVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGKK-PN  239

Query  244  YDIQSI-SNIRAKHKGELPA-LVIDCSHGNSSKDPMKQPQVLRQIIAE--RIESDVRGVM  299
            Y    I +     H+ +LP  LV+D SHGN  K   +Q +V   I  +     +++ G+M
Sbjct  240  YHADDIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTEIAGIM  299

Query  300  LESHLVDGNQKI--SCDITYGQSVTDGCLGWEKTENLLLEMA  339
             ES L +G QKI     +TYGQS+TD CLGWE TE L+ ++A
Sbjct  300  AESFLREGTQKIVGGQPLTYGQSITDPCLGWEDTERLVEKLA  341


 Score = 19.2 bits (38),  Expect = 2.3
 Identities = 14/39 (36%), Positives = 21/39 (54%), Gaps = 6/39 (15%)

Query  314  DITYGQSVTD----GCLGWEKTENLL-LEMADQLAQCPL  347
            D+  GQ + D    G +G   TE+ +  EMA  L+ CP+
Sbjct  145  DMVTGQFIADLISWGAIGARTTESQIHREMASALS-CPV  182


>P00887 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive 
[Escherichia coli (strain K12)]
Length=348

 Score = 290 bits (741),  Expect = 9e-100
 Identities = 154/342 (45%), Positives = 221/342 (65%), Gaps = 7/342 (2%)

Query  4    LNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPC  63
            +N   +  T +  +L  P +L  +Y + P     + + R+ I+ IL G+D RLLV+ GPC
Sbjct  1    MNRTDELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKRLLVIIGPC  60

Query  64   SIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQL  123
            SIHD  +A++YA RL  L++Q + ++ +VMR Y EKPRT +GWKG + DP+L+GS  +  
Sbjct  61   SIHDLTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRVNH  120

Query  124  GLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPF  183
            GLE +R L LQ+ E+G+P A+E L  +   +  DL++WGAIGART+ESQIHRE++S +  
Sbjct  121  GLELARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSC  180

Query  184  PIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPN  243
            P+GFKNGTDG+ +IA+DAI++A+  H FL   + GQ  I Q+SGNP  H+I+RG    PN
Sbjct  181  PVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGKK-PN  239

Query  244  YDIQSI-SNIRAKHKGELPA-LVIDCSHGNSSKDPMKQPQVLRQIIAE--RIESDVRGVM  299
            Y    I +     H+ +LP  LV+D SHGN  K   +Q +V   I  +     + + G+M
Sbjct  240  YHADDIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTAIAGIM  299

Query  300  LESHLVDGNQKI--SCDITYGQSVTDGCLGWEKTENLLLEMA  339
             ES L +G QKI  S  +TYGQS+TD CLGWE TE L+ ++A
Sbjct  300  AESFLREGTQKIVGSQPLTYGQSITDPCLGWEDTERLVEKLA  341


 Score = 19.2 bits (38),  Expect = 2.3
 Identities = 14/39 (36%), Positives = 21/39 (54%), Gaps = 6/39 (15%)

Query  314  DITYGQSVTD----GCLGWEKTENLL-LEMADQLAQCPL  347
            D+  GQ + D    G +G   TE+ +  EMA  L+ CP+
Sbjct  145  DMVTGQFIADLISWGAIGARTTESQIHREMASALS-CPV  182


>Q8X5W4 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive 
[Escherichia coli O157:H7]
Length=348

 Score = 288 bits (738),  Expect = 3e-99
 Identities = 153/342 (45%), Positives = 220/342 (64%), Gaps = 7/342 (2%)

Query  4    LNTLIQKNTTKEITLSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPC  63
            +N   +  T +  +L  P +L  +Y + P     + + R+ I+ IL G+D RLLV+ GPC
Sbjct  1    MNRTDELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKRLLVIIGPC  60

Query  64   SIHDPVSALQYAQRLVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQL  123
            SIHD  +A++YA RL  L++Q + ++ +VMR Y EKPRT +GWKG + DP+L+GS  +  
Sbjct  61   SIHDLTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRINH  120

Query  124  GLEKSRALYLQIIEMGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPF  183
            GLE +R L LQ+ E+G+P A+E L  +   +  DL++WGAIGART+ESQIHRE++S +  
Sbjct  121  GLELARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSC  180

Query  184  PIGFKNGTDGSIQIALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPN  243
            P+GFKNGTDG+ +IA+DAI++A+  H FL   + GQ  I Q+SGNP  H+I+RG    PN
Sbjct  181  PVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGKK-PN  239

Query  244  YDIQSI-SNIRAKHKGELPA-LVIDCSHGNSSKDPMKQPQVLRQIIAE--RIESDVRGVM  299
            Y    I +     H+ +LP  LV+D SHGN  K   +Q +V   I  +     + + G+M
Sbjct  240  YHADDIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTAIAGIM  299

Query  300  LESHLVDGNQKI--SCDITYGQSVTDGCLGWEKTENLLLEMA  339
             ES L +G QKI     +TYGQS+TD CLGWE TE L+ ++A
Sbjct  300  AESFLREGTQKIVGGQPLTYGQSITDPCLGWEDTERLVEKLA  341


 Score = 19.2 bits (38),  Expect = 2.3
 Identities = 14/39 (36%), Positives = 21/39 (54%), Gaps = 6/39 (15%)

Query  314  DITYGQSVTD----GCLGWEKTENLL-LEMADQLAQCPL  347
            D+  GQ + D    G +G   TE+ +  EMA  L+ CP+
Sbjct  145  DMVTGQFIADLISWGAIGARTTESQIHREMASALS-CPV  182


>P35170 Phospho-2-dehydro-3-deoxyheptonate aldolase [Corynebacterium 
glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 
/ JCM 1318 / LMG 3730 / NCIMB 10025)]
Length=366

 Score = 287 bits (734),  Expect = 2e-98
 Identities = 150/334 (45%), Positives = 213/334 (64%), Gaps = 14/334 (4%)

Query  18   LSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPCSIHDPVSALQYAQR  77
            L  P  L A   L P    ++ + RQ I +I AG D RL+VV GPCS+HDP +A+ YA R
Sbjct  24   LPSPTDLIAANPLTPKQASKVEQDRQDIADIFAGDDDRLVVVVGPCSVHDPEAAIDYANR  83

Query  78   LVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQIIE  137
            L  L  ++   + +VMR Y EKPRT +GWKG + DP+L+ + D+  GL  +R + + ++ 
Sbjct  84   LAPLAKRLDQDLKIVMRVYFEKPRTIVGWKGLINDPHLNETYDIPEGLRIARKVLIDVVN  143

Query  138  MGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSIQI  197
            + LP+  E L P +  Y+ D +AWGAIGART+ESQ+HR+++S M  PIGFKNGTDG+IQ+
Sbjct  144  LDLPVGCEFLEPNSPQYYADTVAWGAIGARTTESQVHRQLASGMSMPIGFKNGTDGNIQV  203

Query  198  ALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIRAKHK  257
            A+DA+Q+AQN H F G S  G  ++++++GN   H+ILRG   GPN+D  S+  +  K  
Sbjct  204  AVDAVQAAQNPHFFFGTSDDGALSVVETAGNSNSHIILRGGTSGPNHDAASVEAVVEK-L  262

Query  258  GELPALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD---VRGVMLESHLVDGNQKISC-  313
            GE   L+ID SH NS KD ++Q +V+R+ IAE+I      V G+M+ES LV G Q +   
Sbjct  263  GENARLMIDASHANSGKDHIRQVEVVRE-IAEQISGGSEAVAGIMIESFLVGGAQNLDPA  321

Query  314  --------DITYGQSVTDGCLGWEKTENLLLEMA  339
                     + YGQSVTD C+  + T +LL E+A
Sbjct  322  KLRINGGEGLVYGQSVTDKCIDIDTTIDLLAELA  355


>P79023 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited 
[Candida albicans (strain SC5314 / ATCC MYA-2876)]
Length=370

 Score = 285 bits (730),  Expect = 8e-98
 Identities = 149/332 (45%), Positives = 214/332 (64%), Gaps = 14/332 (4%)

Query  21   PQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPCSIHDPVSALQYAQRLVK  80
            P  L+ +   +   L+ + + R     IL G D R +V+ GPCSIHDP  AL+Y +RL K
Sbjct  24   PALLQHEIKASAESLDVVIKGRYDSAQILKGNDDRCIVIVGPCSIHDPPQALEYGKRLKK  83

Query  81   LQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQIIEM-G  139
            L D++KD + ++MRAYLEKPRTT+GWKG + DP++D S D+  GL+ SR LY  +  + G
Sbjct  84   LADELKDDLVIIMRAYLEKPRTTVGWKGLINDPDVDNSFDINRGLKISRQLYSDLTSVVG  143

Query  140  LPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSIQIAL  199
            LPI SE+L  ++  YF D L++GAIGART+ESQ+HRE++S + FPIGFKNGTDG + +AL
Sbjct  144  LPIGSEMLDTISPQYFSDFLSFGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLAVAL  203

Query  200  DAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIR---AKH  256
            DA+Q++   H F+G+++ G  AI  + GN    +ILRG     NYD++S+   +   AK 
Sbjct  204  DAVQASSKGHHFMGVTKNGMAAITTTKGNDCCFIILRGGKKITNYDVESVKAAKEAIAKC  263

Query  257  KGELPALVIDCSHGNSSKDPMKQPQVLRQIIAERI---ESDVRGVMLESHLVDGNQKI--  311
                  L++DCSH NS KD   QPQVL   +AE+I   E  + GVM+ES++ +G Q +  
Sbjct  264  TDPSIKLMVDCSHDNSRKDYRNQPQVL-DSVAEQISNGEDSIIGVMIESNIHEGKQPMPP  322

Query  312  ----SCDITYGQSVTDGCLGWEKTENLLLEMA  339
                   + YG S+TDGC+ WE T  +L +++
Sbjct  323  AGSGKEALKYGVSITDGCVSWETTVEMLTKLS  354


>P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited 
[Saccharomyces cerevisiae (strain ATCC 204508 
/ S288c)]
Length=370

 Score = 281 bits (719),  Expect = 4e-96
 Identities = 145/336 (43%), Positives = 224/336 (67%), Gaps = 14/336 (4%)

Query  18   LSLPQQLKAKYSLAPIFLEQIAEHRQTIQNILAGKDSRLLVVTGPCSIHDPVSALQYAQR  77
            L+ P  L+ ++ ++    E I + R ++ +IL GKD RL++V GPCS+HDP +A  YA R
Sbjct  25   LTPPDLLQHEFPISAKGEENIIKARDSVCDILNGKDDRLVIVIGPCSLHDPKAAYDYADR  84

Query  78   LVKLQDQVKDQIFLVMRAYLEKPRTTIGWKGFLYDPNLDGSSDLQLGLEKSRALYLQIIE  137
            L K+ +++   + ++MRAYLEKPRTT+GWKG + DP+++ S  +  GL  SR ++++++E
Sbjct  85   LAKISEKLSKDLLIIMRAYLEKPRTTVGWKGLINDPDMNNSFQINKGLRISREMFIKLVE  144

Query  138  MGLPIASEILSPMATGYFDDLLAWGAIGARTSESQIHREISSHMPFPIGFKNGTDGSIQI  197
              LPIA E+L  ++  +  D  + GAIGART+ESQ+HRE++S + FPIGFKNGTDG +Q+
Sbjct  145  K-LPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLQV  203

Query  198  ALDAIQSAQNEHQFLGMSQLGQPAILQSSGNPLPHLILRGANDGPNYDIQSISNIRAK-H  256
            A+DA+++A +EH FL +++ G  AI+ + GN    LILRG  +G N+D +S+ N + +  
Sbjct  204  AIDAMRAAAHEHYFLSVTKPGVTAIVGTEGNKDTFLILRGGKNGTNFDKESVQNTKKQLE  263

Query  257  KGEL-----PALVIDCSHGNSSKDPMKQPQVLRQIIAERIESD--VRGVMLESHLVDGNQ  309
            K  L       ++IDCSHGNS+KD   QP+V + I  +  E +  + GVM+ES++ +G Q
Sbjct  264  KAGLTDDSQKRIMIDCSHGNSNKDFKNQPKVAKCIYDQLTEGENSLCGVMIESNINEGRQ  323

Query  310  KISCD-----ITYGQSVTDGCLGWEKTENLLLEMAD  340
             I  +     + YG SVTD C+GWE TE +L  +A+
Sbjct  324  DIPKEGGREGLKYGCSVTDACIGWESTEQVLELLAE  359



Lambda      K        H        a         alpha
   0.319    0.135    0.393    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1416032


  Database: 457804fc88e28a3a30a26c8c265ba3b3.SwissProt.fasta
    Posted date:  May 9, 2024  4:49 AM
  Number of letters in database: 5,378
  Number of sequences in database:  15



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40