BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 72f691e8d48dd07f6910e9d4fa90bc2d.SwissProt.fasta
22 sequences; 7,976 total letters
Query= ACIAD1906
Length=336
Score E
Sequences producing significant alignments: (Bits) Value
Q7UT69 GTP 3',8-cyclase [Rhodopirellula baltica (strain DSM 10527... 218 1e-71
P39757 GTP 3',8-cyclase [Bacillus subtilis (strain 168)] 216 5e-71
B9KDV3 GTP 3',8-cyclase [Campylobacter lari (strain RM2100 / D67 ... 211 1e-69
A7Z9P0 GTP 3',8-cyclase [Bacillus velezensis (strain DSM 23117 / ... 211 2e-69
A7GU01 GTP 3',8-cyclase [Bacillus cytotoxicus (strain DSM 22905 /... 211 4e-69
A1VXP5 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serot... 208 3e-68
Q9PIW6 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serot... 208 3e-68
A8FJX0 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serot... 208 3e-68
C3LA56 GTP 3',8-cyclase [Bacillus anthracis (strain CDC 684 / NRR... 208 4e-68
Q5HX04 GTP 3',8-cyclase [Campylobacter jejuni (strain RM1221)] 207 5e-68
Q8CNE6 GTP 3',8-cyclase [Staphylococcus epidermidis (strain ATCC ... 207 6e-68
Q5HLY1 GTP 3',8-cyclase [Staphylococcus epidermidis (strain ATCC ... 207 6e-68
Q4L8D2 GTP 3',8-cyclase [Staphylococcus haemolyticus (strain JCSC... 207 6e-68
Q9ZIM6 GTP 3',8-cyclase [Staphylococcus carnosus (strain TM300)] 203 4e-66
P69848 GTP 3',8-cyclase [Staphylococcus aureus (strain NCTC 8325 ... 201 2e-65
Q93KD1 GTP 3',8-cyclase [Peptoclostridium acidaminophilum] 200 3e-65
Q9X5W3 GTP 3',8-cyclase [Rhodobacter capsulatus] 184 6e-59
Q44118 GTP 3',8-cyclase [Paenarthrobacter nicotinovorans] 184 8e-59
P9WJS3 GTP 3',8-cyclase 1 [Mycobacterium tuberculosis (strain ATC... 180 4e-57
Q8IQF1 GTP 3',8-cyclase / Cyclic pyranopterin monophosphate synth... 184 1e-56
Q39055 GTP 3',8-cyclase, mitochondrial [Arabidopsis thaliana] 176 5e-55
Q9NZB8 GTP 3',8-cyclase / Cyclic pyranopterin monophosphate synth... 180 1e-54
>Q7UT69 GTP 3',8-cyclase [Rhodopirellula baltica (strain DSM 10527
/ NCIMB 13988 / SH1)]
Length=359
Score = 218 bits (554), Expect = 1e-71
Identities = 134/344 (39%), Positives = 204/344 (59%), Gaps = 22/344 (6%)
Query 3 PAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQN 61
P D++GR LRIS+TDRCN +C YCMPEH E++ + +L FE + +V+
Sbjct 27 PIALVDRFGRRHDSLRISITDRCNIRCFYCMPEHDAEFLPRSGVLTFEEIERLAGLLVKR 86
Query 62 -GIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDD 120
G++ IRITGGEPL+R+ V +R L ++ GL+ +SMTTN L +A DL+ AGL
Sbjct 87 CGVRDIRITGGEPLVRRDCVDLIRMLARID--GLEDLSMTTNGMLLRDHAADLRSAGLKR 144
Query 121 LNISLDSLDAQQFLKLTKK-SIEPVLQGIQAAQLVGLP-FKINTVLMKGKNDDQILPLVN 178
LN+SLD+LD F+K+ ++ ++ V+ GI AA G K+N + ++G ++ +++ LV
Sbjct 145 LNVSLDTLDEATFVKIARRPGVDRVIDGIDAAIEAGFESIKLNALAIRGLSESELVGLVR 204
Query 179 WAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQF-DLRELKQEH--EPARLY 235
++ S+ LRFIEFMPLD D W + DV++ L +L+ F D+ +E+ PA +
Sbjct 205 FSIEKSVTLRFIEFMPLDSDRAWKSKDVLSGDACLKLLSEAFGDVTPTGRENPSAPAETF 264
Query 236 RL---NDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKN 292
L E IGII +++ FCG+C+R+RLTA G L NCLF+ PL D + + +
Sbjct 265 TLRCDGREGTIGIIRSVTRPFCGDCNRLRLTADGGLRNCLFSQSE---TPLRDAMRSGCD 321
Query 293 TD-LRQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
D L Q +Q+ + EK H A G S + +P + +MH +GG
Sbjct 322 DDKLIQKIQQCVGEK------HAAHGIDSDDFRPPERAMHAIGG 359
>P39757 GTP 3',8-cyclase [Bacillus subtilis (strain 168)]
Length=341
Score = 216 bits (549), Expect = 5e-71
Identities = 133/341 (39%), Positives = 205/341 (60%), Gaps = 22/341 (6%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEH---PEW--IKKKDLLDFEALY-LFCEFMVQN 61
D+ R R LRISVTDRCNF+C YCMP P++ +KK++LL FE L L F+ +
Sbjct 10 DKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDYPFLKKEELLSFEELERLATLFVTRF 69
Query 62 GIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDL 121
G++KIR+TGGEPLMR+ + ++ L ++ G++ I+MTTN L YA LK+AGL +
Sbjct 70 GVEKIRLTGGEPLMRKDMPELIKKLARIP--GIRDIAMTTNGSLLPVYAKRLKEAGLKRV 127
Query 122 NISLDSLDAQQFLKLTKK--SIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNW 179
ISLDSL+ ++F K+ + S+ VL+GI+AA+ GL KIN V+ KG N+ ILP+ +
Sbjct 128 TISLDSLEDERFKKINGRGVSVSKVLEGIEAAKQAGLGVKINMVVQKGVNEKDILPMARY 187
Query 180 AKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLYR- 236
K LRFIEFM + W DV+T+ EI+ ++ + + + E A +R
Sbjct 188 FKEKGHILRFIEFMDVGNTNQWEKKDVMTKAEIIDLINKHMPVEPIAPNYIGEVASRFRY 247
Query 237 LNDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLK-PLLDQIVAEKNTDL 295
L+ +IG+IS++S +FCG C+R RL+A+GEL+ CLFA G L+ P+ ++ ++ +++
Sbjct 248 LDGSGEIGVISSVSDAFCGSCNRARLSARGELFTCLFASSGFDLRAPVRQELSDDELSEM 307
Query 296 RQTLQRTIHEKISA-YIWHKAKGFHSLNKQPRKISMHTLGG 335
T+ + ++ S KA G +K+ M +GG
Sbjct 308 IGTVWKNRIDQYSVDRTLSKASG-------KKKVEMSYIGG 341
>B9KDV3 GTP 3',8-cyclase [Campylobacter lari (strain RM2100 /
D67 / ATCC BAA-1060)]
Length=322
Score = 211 bits (538), Expect = 1e-69
Identities = 117/277 (42%), Positives = 171/277 (62%), Gaps = 7/277 (3%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
D YGR LRISVT RCNF+C+YCMP+ P EW K++LL FE L++F + + G++KI
Sbjct 4 DSYGRVIDYLRISVTQRCNFRCLYCMPKTPFEWSAKENLLSFEELFMFVKVCIDEGVKKI 63
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
RITGGEPL+R+ + F+ + + + +++TTNA L + A DL+QAGL +NISLD
Sbjct 64 RITGGEPLVRKDLYKFIAMISEYKQD--IDLALTTNASLLKQQAKDLRQAGLKRINISLD 121
Query 127 SLDAQQFLKLTKKSI-EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHSI 185
+L KL +K+I + VL GI A +G K NTV +KG ND + + L+ +AK
Sbjct 122 TLKEDVAFKLAQKNILKDVLNGIDEALNLGFNVKFNTVALKGINDSEFIDLLEFAKVRKS 181
Query 186 PLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRE-LKQEHEPARLYRLNDEYDIG 244
+RFIEFM + + + + EIL+++A ++ ++ K + PA +Y L D Y G
Sbjct 182 QIRFIEFM--ENYHAYGDLKGLKSAEILNIIAQKYSFKQGEKSSNAPATIYELEDGYKFG 239
Query 245 IISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLK 281
II SH FC C+RIRL+A+G L CL+ + L +K
Sbjct 240 IIDPHSHDFCDSCNRIRLSAEGLLIPCLYYDEALSIK 276
>A7Z9P0 GTP 3',8-cyclase [Bacillus velezensis (strain DSM 23117
/ BGSC 10A6 / LMG 26770 / FZB42)]
Length=341
Score = 211 bits (538), Expect = 2e-69
Identities = 127/340 (37%), Positives = 197/340 (58%), Gaps = 18/340 (5%)
Query 7 SDQYGRYKRKLRISVTDRCNFKCMYCMPEH---PEW--IKKKDLLDFEALYLFCEFMVQN 61
+D+ R R LRISVTDRCNF+C YCMP P++ ++K +LL FE L + V
Sbjct 9 TDKRERPLRDLRISVTDRCNFRCTYCMPAELFGPDYPFLQKTELLSFEELERLAKLFVGR 68
Query 62 -GIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDD 120
G++KIR+TGGEPLMR+ + ++ L ++ GLK I+MTTN L YA LKQAGL
Sbjct 69 FGVEKIRLTGGEPLMRKDMPELIKKLARIP--GLKDIAMTTNGSLLPVYAEKLKQAGLHR 126
Query 121 LNISLDSLDAQQFLKLTKK--SIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVN 178
+ +SLDSL+ ++F + + S+ VL+GI+AA+ GL KIN V+ KG N+ ILP+
Sbjct 127 VTVSLDSLEDERFKAINGRGVSVNKVLEGIEAAKAAGLGVKINMVVQKGVNEKDILPMAR 186
Query 179 WAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE---PARLY 235
+ K LRFIEFM + W+ DV+T+ EI+ ++ ++ ++ +R
Sbjct 187 YFKEKGHILRFIEFMDVGNTNQWNKKDVITKAEIIDLINQHMPTEPIEANYKGEVASRFR 246
Query 236 RLNDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDL 295
L+ +IG+IS++S +FC C+R RL+A+GEL+ CLFA G ++ L+ + + +L
Sbjct 247 YLDGSGEIGVISSVSDAFCASCNRARLSARGELFTCLFASSGYDVRKLVRGGLTD--DEL 304
Query 296 RQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+++ + Y +A S +K+ M +GG
Sbjct 305 TESIASVWRNRTDQYSIDRAL---SKTDGKKKVEMSYIGG 341
>A7GU01 GTP 3',8-cyclase [Bacillus cytotoxicus (strain DSM 22905
/ CIP 110041 / 391-98 / NVH 391-98)]
Length=337
Score = 211 bits (536), Expect = 4e-69
Identities = 123/338 (36%), Positives = 195/338 (58%), Gaps = 17/338 (5%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEH---PEW--IKKKDLLDFEALYLFCEFMVQNG 62
D +GR + LRISV DRCNF+C YCMP P++ ++++ LL F+ + + G
Sbjct 7 DSFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLQEEFLLTFDEIERLAKLFAGIG 66
Query 63 IQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLN 122
++KIR+TGGEPL+R+ + ++ L L G+ I +TTN +L K A LK+AGL +N
Sbjct 67 VKKIRLTGGEPLLRKDLPKLIKRLASLD--GITDIGLTTNGIHLTKQAKALKEAGLQRVN 124
Query 123 ISLDSLDAQQFLKLTKKSI--EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWA 180
+SLD+++ F K+ +++ +PVL+GI AA+ VGL K+N V+ KG ND Q+LP+
Sbjct 125 VSLDAIEDNVFQKINGRNVSTKPVLKGIIAAKEVGLEVKVNMVVKKGMNDSQVLPMATCF 184
Query 181 KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLY-RL 237
K IPLRFIEFM + W+ VVT+QE++ ++ + + + + E A+ Y +
Sbjct 185 KEQGIPLRFIEFMDVGSTNGWNFEQVVTKQELIEMIGNVYPIEPAEPHYFGEVAKRYCYI 244
Query 238 NDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQ 297
+ ++G I+++S SFC C R R++A G+ Y CLFA +G L+ LL ++ +L Q
Sbjct 245 GSDVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGTDLRALLRTNCSD--NELLQ 302
Query 298 TLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+Q + Y + + K KI M +GG
Sbjct 303 VIQDVWRYRKDRYSDERTE---ESAKNRAKIEMSYIGG 337
>A1VXP5 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serotype
O:23/36 (strain 81-176)]
Length=320
Score = 208 bits (529), Expect = 3e-68
Identities = 118/302 (39%), Positives = 187/302 (62%), Gaps = 8/302 (3%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
DQ+GR LRISVT RCNF+C+YCMP+ P ++ K++LL FE L+LF + + GI+KI
Sbjct 4 DQFGRKINYLRISVTQRCNFRCLYCMPKIPFDYQPKENLLSFEELFLFVKAAIDEGIEKI 63
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
RITGGEPL+R+ + F++ + +S +++TTN L +A DLK AGL LNISLD
Sbjct 64 RITGGEPLLRKDLSIFIKMISDYKSD--IDLAITTNGFLLKDFAKDLKNAGLKRLNISLD 121
Query 127 SLDAQQFLKLTKKSI-EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHSI 185
+LD ++ L +K + + VL GI A + L K+NTV +K NDD+++ L+ +AK+
Sbjct 122 TLDHKKAKTLAQKDVLDSVLSGIDEALNLDLKVKLNTVALKNLNDDELISLLEFAKSKKA 181
Query 186 PLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE-PARLYRLNDEYDIG 244
+RFIEFM + + + EI+ +L+ ++ ++ +K++ + P +Y+ D+Y+ G
Sbjct 182 QIRFIEFM--ENTHAYGKLQGLKRDEIIQILSQKYQIQLIKKDEKAPVSIYKA-DDYEFG 238
Query 245 IISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIH 304
II SH FC C+RIRL+A+G L CL+ + L +K + + + ++ Q + R
Sbjct 239 IIDPHSHEFCDSCNRIRLSAEGLLIPCLYFDEALSIKEAVRKGDIKAAVEILQEVLRNKP 298
Query 305 EK 306
EK
Sbjct 299 EK 300
>Q9PIW6 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serotype
O:2 (strain ATCC 700819 / NCTC 11168)]
Length=320
Score = 208 bits (529), Expect = 3e-68
Identities = 118/302 (39%), Positives = 187/302 (62%), Gaps = 8/302 (3%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
DQ+GR LRISVT RCNF+C+YCMP+ P ++ K++LL FE L+LF + + GI+KI
Sbjct 4 DQFGRKINYLRISVTQRCNFRCLYCMPKIPFDYQPKENLLSFEELFLFVKAAIDEGIEKI 63
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
RITGGEPL+R+ + F++ + +S +++TTN L +A DLK AGL LNISLD
Sbjct 64 RITGGEPLLRKDLSIFIKMISDYKSD--IDLAITTNGFLLKDFAKDLKNAGLKRLNISLD 121
Query 127 SLDAQQFLKLTKKSI-EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHSI 185
+LD ++ L +K + + VL GI A + L K+NTV +K NDD+++ L+ +AK+
Sbjct 122 TLDHKKAKTLAQKDVLDSVLSGIDEALNLDLKVKLNTVALKNLNDDELISLLEFAKSKKA 181
Query 186 PLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE-PARLYRLNDEYDIG 244
+RFIEFM + + + EI+ +L+ ++ ++ +K++ + P +Y+ D+Y+ G
Sbjct 182 QIRFIEFM--ENTHAYGKLQGLKRDEIIQILSQKYQIQLIKKDEKAPVSIYKA-DDYEFG 238
Query 245 IISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIH 304
II SH FC C+RIRL+A+G L CL+ + L +K + + + ++ Q + R
Sbjct 239 IIDPHSHEFCDSCNRIRLSAEGLLIPCLYFDEALSIKEAVRKGDIKAAVEILQEVLRNKP 298
Query 305 EK 306
EK
Sbjct 299 EK 300
>A8FJX0 GTP 3',8-cyclase [Campylobacter jejuni subsp. jejuni serotype
O:6 (strain 81116 / NCTC 11828)]
Length=320
Score = 208 bits (529), Expect = 3e-68
Identities = 118/302 (39%), Positives = 187/302 (62%), Gaps = 8/302 (3%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
DQ+GR LRISVT RCNF+C+YCMP+ P ++ K++LL FE L+LF + + GI+KI
Sbjct 4 DQFGRKINYLRISVTQRCNFRCLYCMPKIPFDYQPKENLLSFEELFLFVKAAIDEGIEKI 63
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
RITGGEPL+R+ + F++ + +S +++TTN L +A DLK AGL LNISLD
Sbjct 64 RITGGEPLLRKDLSIFIKMISDYKSD--IDLAITTNGFLLKDFAKDLKNAGLKRLNISLD 121
Query 127 SLDAQQFLKLTKKSI-EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHSI 185
+LD ++ L +K + + VL GI A + L K+NTV +K NDD+++ L+ +AK+
Sbjct 122 TLDHKKAKTLAQKDVLDSVLSGIDEALNLDLKVKLNTVALKNLNDDELISLLEFAKSKKA 181
Query 186 PLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE-PARLYRLNDEYDIG 244
+RFIEFM + + + EI+ +L+ ++ ++ +K++ + P +Y+ D+Y+ G
Sbjct 182 QIRFIEFM--ENTHAYGKLQGLKRDEIIQILSQKYQIQLIKKDEKAPVSIYKA-DDYEFG 238
Query 245 IISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIH 304
II SH FC C+RIRL+A+G L CL+ + L +K + + + ++ Q + R
Sbjct 239 IIDPHSHEFCDSCNRIRLSAEGLLIPCLYFDEALSIKEAVRKGDIKAAVEILQEVLRNKP 298
Query 305 EK 306
EK
Sbjct 299 EK 300
>C3LA56 GTP 3',8-cyclase [Bacillus anthracis (strain CDC 684 /
NRRL 3495)]
Length=338
Score = 208 bits (529), Expect = 4e-68
Identities = 126/339 (37%), Positives = 196/339 (58%), Gaps = 18/339 (5%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEH---PEW--IKKKDLLDFEALYLFCEFMVQNG 62
D+ R + LRISVTDRCNF+C YCMPE P++ + +L F+ + V G
Sbjct 7 DKLQRPLKDLRISVTDRCNFRCRYCMPEEIFGPDYSFLSNDKILSFDEIERITRIFVSLG 66
Query 63 IQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLN 122
++K+RITGGEPL+R+G+ + L K+ G++ I +TTN L K+A DL +AGL +
Sbjct 67 VRKLRITGGEPLLRRGLPQLIERLNKVD--GVEDIGLTTNGSLLKKFAPDLYKAGLSRVT 124
Query 123 ISLDSLDAQQFLKLT--KKSIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWA 180
+SLDSL+ ++F L + ++ VL+GIQAA VG+ KIN V+ KGKN+ IL + +
Sbjct 125 VSLDSLEEERFFYLNGNRSKVQRVLEGIQAAAEVGMKIKINMVVQKGKNEQDILQMAQYF 184
Query 181 KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLYR-L 237
K + LRFIE+M + W +VV++QEI+ ++ L ++ + E A Y +
Sbjct 185 KENKHILRFIEYMDVGNYNGWELKEVVSKQEIVDMIHQVMPLERIEANYAGEVATRYSYI 244
Query 238 NDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLL-DQIVAEKNTDLR 296
+ +IG+IS+++ SFC C R R++A+G+LY CLFA +G L+ LL E+ TD+
Sbjct 245 GSDEEIGVISSVTDSFCSSCTRARISAEGKLYTCLFASKGNDLRELLRSDYTDEEITDVV 304
Query 297 QTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+ + ++ S + +S K KI M +GG
Sbjct 305 RDIWNNREDRYS-----DERLSNSNKKAMPKIEMSHIGG 338
>Q5HX04 GTP 3',8-cyclase [Campylobacter jejuni (strain RM1221)]
Length=320
Score = 207 bits (527), Expect = 5e-68
Identities = 118/302 (39%), Positives = 187/302 (62%), Gaps = 8/302 (3%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-EWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
DQ+GR LRISVT RCNF+C+YCMP+ P ++ K++LL FE L+LF + + GI+KI
Sbjct 4 DQFGRKINYLRISVTQRCNFRCLYCMPKIPFDYQPKENLLSFEELFLFVKAAMDEGIEKI 63
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
RITGGEPL+R+ + F++ + +S +++TTN L +A DLK AGL LNISLD
Sbjct 64 RITGGEPLLRKDLSIFIKMISDYKSD--IDLAITTNGFLLKDFAKDLKNAGLKRLNISLD 121
Query 127 SLDAQQFLKLTKKSI-EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHSI 185
+LD ++ L +K + + VL GI A + L K+NTV +K NDD+++ L+ +AK+
Sbjct 122 TLDHKKAKTLAQKDVLDSVLSGIDEALNLDLKVKLNTVALKNLNDDELISLLEFAKSKKA 181
Query 186 PLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE-PARLYRLNDEYDIG 244
+RFIEFM + + + EI+ +L+ ++ ++ +K++ + P +Y+ D+Y+ G
Sbjct 182 QIRFIEFM--ENTHAYGKLQGLKRDEIIQILSQKYQIQLIKKDEKAPVSIYKA-DDYEFG 238
Query 245 IISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQRTIH 304
II SH FC C+RIRL+A+G L CL+ + L +K + + + ++ Q + R
Sbjct 239 IIDPHSHEFCDSCNRIRLSAEGLLIPCLYFDEALSIKEAVRKGDIKAAVEILQEVLRNKP 298
Query 305 EK 306
EK
Sbjct 299 EK 300
>Q8CNE6 GTP 3',8-cyclase [Staphylococcus epidermidis (strain ATCC
12228 / FDA PCI 1200)]
Length=340
Score = 207 bits (528), Expect = 6e-68
Identities = 123/342 (36%), Positives = 201/342 (59%), Gaps = 16/342 (5%)
Query 5 IFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHP-----EWIKKKDLLDFEALYLFCEFMV 59
+ D+ GR R LRISVTDRCNF+C YCMP+ ++ K +LL FE L +
Sbjct 4 VIQDKLGRPIRDLRISVTDRCNFRCDYCMPKEIFGDDYTFLPKNELLTFEELTRISKIYA 63
Query 60 QNGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLD 119
Q G++KIRITGGEPL+R+ + V L + G++ I +TTN L K+ +L QAGL
Sbjct 64 QLGVKKIRITGGEPLLRRNLYKLVEQLNLID--GIEDIGLTTNGLLLKKHGKNLYQAGLR 121
Query 120 DLNISLDSLDAQQFLKLTKKSIEP--VLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLV 177
+N+SLD+++ F ++ ++I+ +L+ I A +G K+N V+ KG ND+QI+P++
Sbjct 122 RINVSLDAIEDNVFQEINNRNIKASTILEQIDYAVSIGFEVKVNVVIQKGVNDNQIIPMI 181
Query 178 NWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLY 235
++ K +I +RFIEFM + D W+ + VVT++E+L+++ F++ + ++ E A+ +
Sbjct 182 DYFKNKNIEVRFIEFMDVGNDNGWNFNKVVTKEEMLNMIEQHFEISPVAPKYYGEVAKYF 241
Query 236 RLND-EYDIGIISTISHSFCGECDRIRLTAQGELYNCLFA-PQGLMLKPLLDQIVAEKNT 293
R D + G+I+++S SFC C R RL++ G+ Y CLFA +G +K L+ +
Sbjct 242 RHKDSDAQFGLITSVSESFCSTCTRARLSSDGKFYGCLFASSEGFDVKALIRN--GATDD 299
Query 294 DLRQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
DL+ +R + Y K N + +KI+M+ +GG
Sbjct 300 DLKAQFKRLWSIRNDQYS-DKRTMQTIENNRKKKINMNYIGG 340
>Q5HLY1 GTP 3',8-cyclase [Staphylococcus epidermidis (strain ATCC
35984 / RP62A)]
Length=340
Score = 207 bits (528), Expect = 6e-68
Identities = 123/342 (36%), Positives = 201/342 (59%), Gaps = 16/342 (5%)
Query 5 IFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHP-----EWIKKKDLLDFEALYLFCEFMV 59
+ D+ GR R LRISVTDRCNF+C YCMP+ ++ K +LL FE L +
Sbjct 4 VIQDKLGRPIRDLRISVTDRCNFRCDYCMPKEIFGDDYTFLPKNELLTFEELTRISKIYA 63
Query 60 QNGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLD 119
Q G++KIRITGGEPL+R+ + V L + G++ I +TTN L K+ +L QAGL
Sbjct 64 QLGVKKIRITGGEPLLRRNLYKLVEQLNLID--GIEDIGLTTNGLLLKKHGKNLYQAGLR 121
Query 120 DLNISLDSLDAQQFLKLTKKSIEP--VLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLV 177
+N+SLD+++ F ++ ++I+ +L+ I A +G K+N V+ KG ND+QI+P++
Sbjct 122 RINVSLDAIEDNVFQEINNRNIKASTILEQIDYAVSIGFEVKVNVVIQKGVNDNQIIPMI 181
Query 178 NWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLY 235
++ K +I +RFIEFM + D W+ + VVT++E+L+++ F++ + ++ E A+ +
Sbjct 182 DYFKNKNIEVRFIEFMDVGNDNGWNFNKVVTKEEMLNMIEQHFEISPVAPKYYGEVAKYF 241
Query 236 RLND-EYDIGIISTISHSFCGECDRIRLTAQGELYNCLFA-PQGLMLKPLLDQIVAEKNT 293
R D + G+I+++S SFC C R RL++ G+ Y CLFA +G +K L+ +
Sbjct 242 RHKDSDAQFGLITSVSESFCSTCTRARLSSDGKFYGCLFASSEGFDVKALIRN--GATDD 299
Query 294 DLRQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
DL+ +R + Y K N + +KI+M+ +GG
Sbjct 300 DLKAQFKRLWSIRNDQYS-DKRTMQTIENNRKKKINMNYIGG 340
>Q4L8D2 GTP 3',8-cyclase [Staphylococcus haemolyticus (strain
JCSC1435)]
Length=340
Score = 207 bits (528), Expect = 6e-68
Identities = 123/343 (36%), Positives = 199/343 (58%), Gaps = 16/343 (5%)
Query 4 AIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHP-----EWIKKKDLLDFEALYLFCEFM 58
A D+ GR R LRISVTDRCNF+C YCMP+ ++ K +LL FE + +
Sbjct 3 AQIKDKLGRPIRDLRISVTDRCNFRCDYCMPKEIFGDDYVFLPKDELLTFEEMVRIAKVY 62
Query 59 VQNGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGL 118
+ G++K+RITGGEPL+R+ + + +L ++ G++ I MTTN L K+ L AGL
Sbjct 63 AELGVKKLRITGGEPLLRRNLYQLIAELNQID--GIEDIGMTTNGLLLKKHGQKLYDAGL 120
Query 119 DDLNISLDSLDAQQFLKLTKKSIEP--VLQGIQAAQLVGLPFKINTVLMKGKNDDQILPL 176
+N+SLD++D + F + ++I+ +L I A +G K+N V+ KG NDDQI+P+
Sbjct 121 RRINVSLDAIDNEVFQAINNRNIKATTILDQIDYAVSIGFHVKVNVVIQKGINDDQIIPM 180
Query 177 VNWAKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARL 234
V++ K +I +RFIEFM + D W VVT+ E+L ++ + FD+ + ++ E A+
Sbjct 181 VDYFKDKNIEIRFIEFMDVGNDNGWDFSKVVTKNEMLDMIESHFDIEPVPPKYFGEVAKY 240
Query 235 YRLNDE-YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAP-QGLMLKPLLDQIVAEKN 292
Y+ D G+I+++S SFC C R RL++ G+ Y CLF+ +G +K + V +
Sbjct 241 YKHKDNGAQFGLITSVSASFCSTCTRARLSSDGKFYGCLFSTVEGFNIKSFIRSGVTD-- 298
Query 293 TDLRQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+LR+ L + + Y + + N+Q +KI+M+ +GG
Sbjct 299 DELREQLITLWNVRDDRYSDERTEQTVK-NRQRKKINMNYIGG 340
>Q9ZIM6 GTP 3',8-cyclase [Staphylococcus carnosus (strain TM300)]
Length=340
Score = 203 bits (516), Expect = 4e-66
Identities = 120/340 (35%), Positives = 197/340 (58%), Gaps = 16/340 (5%)
Query 7 SDQYGRYKRKLRISVTDRCNFKCMYCMPEHP-----EWIKKKDLLDFEALYLFCEFMVQN 61
+D+ GR R LR+SVTDRCNF+C YCMP+ ++ K +LL F +
Sbjct 6 TDKLGRPIRDLRLSVTDRCNFRCDYCMPKEIFGDDFVFLPKDELLSFSEMERIARVYTHL 65
Query 62 GIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDL 121
G++KIRITGGEPLMR+ + + L ++ G++ I +TTN L K+ L AGL +
Sbjct 66 GVKKIRITGGEPLMRRDLYKLIAALNEIE--GVEDIGLTTNGLLLKKHGQKLYDAGLRRI 123
Query 122 NISLDSLDAQQFLKLTKKSI--EPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNW 179
N+SLD++D + F + ++I + +L+ I A +G KIN V+ KG NDDQI+P+V +
Sbjct 124 NVSLDAIDNELFQSINNRNIKADTILEQIDYAVSIGFKVKINVVVQKGVNDDQIIPMVQY 183
Query 180 AKAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLYRL 237
K +I +RFIEFM + D W VV++ E+LS++ +FD+ ++ ++ E A+ YR
Sbjct 184 FKDKNIQVRFIEFMDVGNDNGWDFSKVVSKDEMLSMIQEEFDIEAVEPKYYGEVAKYYRH 243
Query 238 NDE-YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAP-QGLMLKPLLDQIVAEKNTDL 295
D G+I+++S SFC C R RL++ G+ Y CLF+ G +K + V++ +L
Sbjct 244 KDNGAQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFSTVDGFNVKEFMRSGVSD--DEL 301
Query 296 RQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+ + + + Y + + ++ K+ +KI+M+ +GG
Sbjct 302 QAKFEELWNIRDDRYSDERTEQTVAIRKR-KKINMNYIGG 340
>P69848 GTP 3',8-cyclase [Staphylococcus aureus (strain NCTC 8325
/ PS 47)]
Length=340
Score = 201 bits (512), Expect = 2e-65
Identities = 120/339 (35%), Positives = 196/339 (58%), Gaps = 16/339 (5%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPEHP-----EWIKKKDLLDFEALYLFCEFMVQNG 62
D+ GR R LR+SVTDRCNF+C YCMP+ ++ K +LL F+ + + + G
Sbjct 7 DKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELG 66
Query 63 IQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLN 122
++KIRITGGEPLMR+ + + L ++ G++ I +TTN L K+ L AGL +N
Sbjct 67 VKKIRITGGEPLMRRDLDVLIAKLNQID--GIEDIGLTTNGLLLKKHGQKLYDAGLRRIN 124
Query 123 ISLDSLDAQQFLKLTKKSIEP--VLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWA 180
+SLD++D F + ++I+ +L+ I A +GL K+N V+ KG NDDQI+P++ +
Sbjct 125 VSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYF 184
Query 181 KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLYRLN 238
K I +RFIEFM + D W VVT+ E+L+++ F++ ++ ++ E A+ YR
Sbjct 185 KDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHK 244
Query 239 DE-YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAP-QGLMLKPLLDQIVAEKNTDLR 296
D G+I+++S SFC C R RL++ G+ Y CLFA G +K + V ++ +L+
Sbjct 245 DNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDE--ELK 302
Query 297 QTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
+ + + Y + + N+Q +KI+M+ +GG
Sbjct 303 EQFKALWQIRDDRYSDERTAQTVA-NRQRKKINMNYIGG 340
>Q93KD1 GTP 3',8-cyclase [Peptoclostridium acidaminophilum]
Length=325
Score = 200 bits (509), Expect = 3e-65
Identities = 124/278 (45%), Positives = 172/278 (62%), Gaps = 16/278 (6%)
Query 4 AIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKK---DLLDFEALYLFCEFMVQ 60
++ D YGR LRISVTDRCN +CMYCMP+ E I K+ D++ E L +V+
Sbjct 5 SVLLDGYGRRINYLRISVTDRCNLRCMYCMPQ--EGIPKRAHHDIMTLEELQEVAVALVE 62
Query 61 NGIQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDD 120
GI KIRITGGEPL+R+G+V VR+L K GL I++TTN L++YA +LK AGL
Sbjct 63 LGIDKIRITGGEPLVRKGIVGLVRELSKCE--GLNEITLTTNGLLLSEYARELKAAGLKR 120
Query 121 LNISLDSLDAQQFLKLTK-KSIEPVLQGIQAAQLVGL-PFKINTVLMKGKNDDQILPLVN 178
+NISLD+L+ Q+F +T+ S+E VL+GI+ AQ VGL P K+NTVL+ G NDD+I V
Sbjct 121 VNISLDTLNPQKFEYITRGGSLEKVLEGIKEAQSVGLTPIKLNTVLIGGFNDDEIEDFVA 180
Query 179 WAKAHSIPLRFIEFMPL-DGDALWHNHDVVTEQEILSVLATQFDLRELKQE--HEPARLY 235
+ I +RFIE MP G LW ++ +L + + L ++K E PA Y
Sbjct 181 LTVDNEIDVRFIELMPYRTGSRLWSLEKFISSDSVLKKVPS---LEKIKSEDISSPAEYY 237
Query 236 RLNDEY-DIGIISTISHSFCGECDRIRLTAQGELYNCL 272
R+ +G+I+ I+ FC C+R+RLT+ G+L CL
Sbjct 238 RIPGALGKVGLINPITCKFCENCNRLRLTSDGKLKLCL 275
>Q9X5W3 GTP 3',8-cyclase [Rhodobacter capsulatus]
Length=328
Score = 184 bits (467), Expect = 6e-59
Identities = 115/295 (39%), Positives = 162/295 (55%), Gaps = 24/295 (8%)
Query 1 MSPAIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKDLLDFEALYLFCEFMVQ 60
M P D +GR R LR+SVTDRC+ +C YCM E ++ + +L E L
Sbjct 1 MLPDPLCDGFGRDVRYLRVSVTDRCDLRCSYCMKEDVTFLPRNQVLSLEELDRL------ 54
Query 61 NGIQKIRITGGEPLMRQGVVHFVRDL-QKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLD 119
G++K+R+TGGEPL+R+G+ F + LR+ L +++TTN LA +A L + G+
Sbjct 55 -GVRKLRVTGGEPLVRRGIGTFFAAMGTHLRAGRLDELTLTTNGTQLAAHAQSLAECGVK 113
Query 120 DLNISLDSLDAQQFLKLTKKS-IEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVN 178
+N+SLD+L A+++ +LT+ IE V GI AAQ GL K+N + +KG NDD+I L +
Sbjct 114 RVNVSLDTLQAEKYARLTRFGRIEQVFAGIAAAQAAGLRVKLNAMALKGVNDDEIFALTD 173
Query 179 WAKAHSIPLRFIEFMPLDG-------DALWHNHDVVTEQEILSVLATQFDLREL-KQEHE 230
WA AH L FIE MP+ D W DV L T+F L +
Sbjct 174 WAAAHHCDLTFIELMPMGDIPAGTRLDQFWPLDDVRAH------LETRFRLIDNGLNTGG 227
Query 231 PARLYRL-NDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLL 284
PAR + IG IS +SH+FC C+R+RLT +GELY CL L+P+L
Sbjct 228 PARYVTVAQTGQRIGFISPLSHNFCTSCNRVRLTCKGELYTCLGQEGSSDLRPVL 282
>Q44118 GTP 3',8-cyclase [Paenarthrobacter nicotinovorans]
Length=355
Score = 184 bits (468), Expect = 8e-59
Identities = 112/295 (38%), Positives = 167/295 (57%), Gaps = 20/295 (7%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMP-EHPEWIKKKDLLDFEALYLFCEFMVQN-GIQK 65
D+YGR +R+S+TD+CN +C YCMP E EW+ K+ ++ + V G+++
Sbjct 15 DRYGRRATDMRLSLTDKCNLRCTYCMPAEGLEWLSKQAVMSASEIVRIVGIGVGRLGVRE 74
Query 66 IRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISL 125
+R+TGGEPL+R +V + +L+ R+ ISMTTN LAK LK AGL +N+SL
Sbjct 75 LRLTGGEPLVRHDLVDIIAELR--RNHPELPISMTTNGVGLAKKVAPLKAAGLTRINVSL 132
Query 126 DSLDAQQFLKLTKKS-IEPVLQGIQAAQLVGL-PFKINTVLMKGKNDDQILPLVNWAKAH 183
DSL + F KLT++ ++ VL G+ AA GL P K+N VLM+G ND + L+ WA
Sbjct 133 DSLHEETFTKLTRRPFLDQVLAGVDAAWAAGLGPVKLNAVLMRGINDAEAPSLLAWAVER 192
Query 184 SIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLR--ELKQEHEPARLYRLNDEY 241
LRFIE MPLD D W +++T EI +L+T F L ++ PA + +
Sbjct 193 GYELRFIEQMPLDADHGWTRRNMITAAEIRDLLSTDFVLTPDPRARDGAPAERFEVRRRV 252
Query 242 ------------DIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLL 284
+GII++++ FC +C R R+TA+G + +CLF+ + L LL
Sbjct 253 AGSGAGLGPVLGTVGIIASVTEPFCSDCRRTRITAEGRIMSCLFSREEFDLLVLL 307
>P9WJS3 GTP 3',8-cyclase 1 [Mycobacterium tuberculosis (strain
ATCC 25618 / H37Rv)]
Length=359
Score = 180 bits (457), Expect = 4e-57
Identities = 114/341 (33%), Positives = 179/341 (52%), Gaps = 14/341 (4%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMPE-HPEWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
D+ R LR+SV D+CN +C YCMPE H W+ ++DLL + + + + G+ K+
Sbjct 20 DRCRRMMGDLRLSVIDQCNLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKV 79
Query 67 RITGGEPLMRQGVVHFVRDLQKL--RSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNIS 124
RITGGEPL+R + VR L GL+ +++TTN LA LK AG+ + +S
Sbjct 80 RITGGEPLIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVS 139
Query 125 LDSLDAQQFLKLTKK-SIEPVLQGIQAAQLVGLP-FKINTVLMKGKNDDQILPLVNWAKA 182
LD+L ++F ++++ S + V+ GI+A G KI+T +M+G N D++ L+ +A+
Sbjct 140 LDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFART 199
Query 183 HSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEHE--PARLYRLNDE 240
+ +RFIE+M + G W V T+ +L L ++ E +H+ PA Y L D
Sbjct 200 VNAEVRFIEYMDVGGATHWAWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDG 259
Query 241 YDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLL------DQIVAEKNTD 294
GII++ + FC CDR RLTA G +CL+A G+ L+ L D +V T
Sbjct 260 TTFGIIASTTEPFCATCDRSRLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTG 319
Query 295 LRQTLQRTIHEKISAYIWHKAKGFHSLNKQPRKISMHTLGG 335
R+ R ++++ +L P + MHT GG
Sbjct 320 WRRRTDRGAEQRLAQRERGVFLPLSTLKADPH-LEMHTRGG 359
>Q8IQF1 GTP 3',8-cyclase / Cyclic pyranopterin monophosphate synthase
[Drosophila melanogaster]
Length=565
Score = 184 bits (466), Expect = 1e-56
Identities = 116/344 (34%), Positives = 192/344 (56%), Gaps = 21/344 (6%)
Query 7 SDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKKD-LLDFEALYLFCEFMVQNGIQK 65
+D +GR+ LRIS+T+RCN +C YCMP ++ K+ LL E + V+ G++K
Sbjct 62 TDSFGRHHTYLRISLTERCNLRCDYCMPAEGVPLQPKNKLLTTEEILRLARIFVEQGVRK 121
Query 66 IRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISL 125
IR+TGGEP +R+ +V V ++ L L++I +TTN L + L++AGLD+LNISL
Sbjct 122 IRLTGGEPTVRRDIVEIVAQMKALPE--LEQIGITTNGLVLTRLLLPLQRAGLDNLNISL 179
Query 126 DSLDAQQFLKLTK-KSIEPVLQGIQAAQLVGLPFKINTVLMKGKNDDQILPLVNWAKAHS 184
D+L +F K+T+ K E V+ GI A +G K+N VLM+ N+D+I V + +
Sbjct 180 DTLKRDRFEKITRRKGWERVIAGIDLAVQLGYRPKVNCVLMRDFNEDEICDFVEFTRNRP 239
Query 185 IPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQF-DLRELKQ-EHEPARLYRL-NDEY 241
+ +RFIE+MP G+ WH +++ ++ L ++ ++ D + L ++ ++ Y + +
Sbjct 240 VDVRFIEYMPFSGNK-WHTERLISYKDTLQIIRQRWPDFKALPNGPNDTSKAYAVPGFKG 298
Query 242 DIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLL-DQIVAEKN-TDL---- 295
+G I++++ FCG C+R+RLTA G + CLF + L+ + D+ V+E+ DL
Sbjct 299 QVGFITSMTEHFCGTCNRLRLTADGNIKVCLFGNKEFSLRDAMRDESVSEEQLVDLIGAA 358
Query 296 --RQTLQRT-----IHEKISAYIWHKAKGFHSLNKQPRKISMHT 332
R+ Q +H + Y +H A L Q R S T
Sbjct 359 VQRKKKQHADAAPRLHHHLHPYSYHHAYHTSRLQLQARNYSQLT 402
>Q39055 GTP 3',8-cyclase, mitochondrial [Arabidopsis thaliana]
Length=390
Score = 176 bits (445), Expect = 5e-55
Identities = 111/309 (36%), Positives = 169/309 (55%), Gaps = 11/309 (4%)
Query 8 DQYGRYKRKLRISVTDRCNFKCMYCMP-EHPEWIKKKDLLDFEALYLFCEFMVQNGIQKI 66
D++GR LRIS+T+RCN +C YCMP E E K LL + V G+ KI
Sbjct 68 DKFGRLHTYLRISLTERCNLRCQYCMPSEGVELTPKPQLLSQSEIVRLAGLFVSAGVNKI 127
Query 67 RITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLNISLD 126
R+TGGEP +R+ + L L+ GLK +++TTN LAK LK+ GLD LNISLD
Sbjct 128 RLTGGEPTVRKDIEEICLQLSSLK--GLKNLAITTNGITLAKKLPRLKECGLDSLNISLD 185
Query 127 SLDAQQFLKLTK-KSIEPVLQGIQAAQLVGL-PFKINTVLMKGKNDDQILPLVNWAKAHS 184
+L +F LT+ K + V++ I A +G P K+N V+M+G NDD+I V +
Sbjct 186 TLVPAKFEFLTRRKGHDRVMKSIDTAIELGYNPVKVNCVIMRGLNDDEICDFVELTRDKP 245
Query 185 IPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLRELKQEH--EPARLYRLNDEY- 241
I +RFIEFMP DG+ +W+ +V E++ + +F + Q+H E A+ + ++
Sbjct 246 INVRFIEFMPFDGN-VWNVKKLVPYAEVMDKVVKRFPSIKRMQDHPTETAKNFTIDGHCG 304
Query 242 DIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLKPLLDQIVAEKNTDLRQTLQR 301
+ I++++ FC C+R+RL A G CLF P + L+ L + LR+ +
Sbjct 305 SVSFITSMTEHFCAGCNRLRLLADGNFKVCLFGPSEVSLRDPLRS--GADDEALREIIGA 362
Query 302 TIHEKISAY 310
+ K +A+
Sbjct 363 AVKRKKAAH 371
>Q9NZB8 GTP 3',8-cyclase / Cyclic pyranopterin monophosphate synthase
[Homo sapiens]
Length=636
Score = 180 bits (456), Expect = 1e-54
Identities = 107/284 (38%), Positives = 166/284 (58%), Gaps = 9/284 (3%)
Query 4 AIFSDQYGRYKRKLRISVTDRCNFKCMYCMPEHPEWIKKK-DLLDFEALYLFCEFMVQNG 62
A +D +GR LRIS+T++CN +C YCMPE + K +LL E + V+ G
Sbjct 59 AFLTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKANLLTTEEILTLARLFVKEG 118
Query 63 IQKIRITGGEPLMRQGVVHFVRDLQKLRSIGLKRISMTTNAHYLAKYAYDLKQAGLDDLN 122
I KIR+TGGEPL+R VV V LQ+L GL+ I +TTN LA+ L++AGL +N
Sbjct 119 IDKIRLTGGEPLIRPDVVDIVAQLQRLE--GLRTIGVTTNGINLARLLPQLQKAGLSAIN 176
Query 123 ISLDSLDAQQF-LKLTKKSIEPVLQGIQAAQLVGL-PFKINTVLMKGKNDDQILPLVNWA 180
ISLD+L +F + +K V++GI A +G P K+N V+M+G N+D++L
Sbjct 177 ISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALT 236
Query 181 KAHSIPLRFIEFMPLDGDALWHNHDVVTEQEILSVLATQFDLREL--KQEHEPARLYRL- 237
+ + +RFIE+MP DG+ W+ +V+ +E+L + Q+ E ++E A+ +++
Sbjct 237 EGLPLDVRFIEYMPFDGNK-WNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAKAFKIP 295
Query 238 NDEYDIGIISTISHSFCGECDRIRLTAQGELYNCLFAPQGLMLK 281
+ I I+++S FCG C+R+R+TA G L CLF + L+
Sbjct 296 GFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLR 339
Lambda K H a alpha
0.325 0.140 0.426 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1966536
Database: 72f691e8d48dd07f6910e9d4fa90bc2d.SwissProt.fasta
Posted date: May 30, 2024 2:05 AM
Number of letters in database: 7,976
Number of sequences in database: 22
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
