BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: e39dffb2a1b04b36e6398e858a7bc1ac.SwissProt.fasta
14 sequences; 5,573 total letters
Query= ACIAD2314
Length=397
Score E
Sequences producing significant alignments: (Bits) Value
P55218 O-succinylhomoserine sulfhydrylase [Pseudomonas aeruginosa... 498 3e-180
Q8L0X4 L-methionine gamma-lyase [Fusobacterium nucleatum subsp. p... 343 1e-119
P9WGB5 O-succinylhomoserine sulfhydrylase [Mycobacterium tubercul... 338 4e-117
P9WGB4 O-succinylhomoserine sulfhydrylase [Mycobacterium tubercul... 338 4e-117
Q8RDT4 L-methionine gamma-lyase [Fusobacterium nucleatum subsp. n... 333 1e-115
Q7MX71 L-methionine gamma-lyase [Porphyromonas gingivalis (strain... 318 2e-109
Q73KL7 L-methionine gamma-lyase [Treponema denticola (strain ATCC... 313 2e-107
P13254 L-methionine gamma-lyase [Pseudomonas putida] 295 2e-100
A0A0J6G7P5 L-methionine gamma-lyase [Pseudomonas deceptionensis] 283 1e-95
Q79VI4 O-acetyl-L-homoserine sulfhydrylase [Corynebacterium gluta... 276 8e-93
Q83A83 Cystathionine beta-lyase [Coxiella burnetii (strain RSA 49... 269 2e-90
A2RM21 Cystathionine beta-lyase [Lactococcus lactis subsp. cremor... 263 4e-88
P9WGB7 Cystathionine gamma-synthase [Mycobacterium tuberculosis (... 261 2e-87
O05394 Cystathionine gamma-lyase [Bacillus subtilis (strain 168)] 259 6e-87
>P55218 O-succinylhomoserine sulfhydrylase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=403
Score = 498 bits (1282), Expect = 3e-180
Identities = 235/384 (61%), Positives = 306/384 (80%), Gaps = 0/384 (0%)
Query 13 DTLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFE 72
DTLA+R G R+ EGEH E +F TSS+V+ AA+AAA+F+GEV GN+YSR+TNPTV FE
Sbjct 20 DTLAVRAGQRRTPEGEHGEALFTTSSYVFRTAADAAARFAGEVPGNVYSRYTNPTVRTFE 79
Query 73 KRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVD 132
+R+AA++GAE+AVAT+SGM A+L++ M+ +GDHV+ SR+VFGS ++LF+KY +F +
Sbjct 80 ERIAALEGAEQAVATASGMSAILALVMSLCSSGDHVLVSRSVFGSTISLFDKYFKRFGIQ 139
Query 133 ITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCT 192
+ + L+DL AW+ A +P TK+ F+ESPSNPLAE+ DI ALAEIAHA A+L VDN FCT
Sbjct 140 VDYPPLSDLAAWEAACKPNTKLFFVESPSNPLAELVDIAALAEIAHAKGALLAVDNCFCT 199
Query 193 PALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEVFGVVRTLGPSMSPFNAW 252
PALQQPLKLGAD+V++SATKYIDGQGR +GG V G + ++EV G +RT GP++SPFNAW
Sbjct 200 PALQQPLKLGADVVIHSATKYIDGQGRGMGGVVAGRGEQMKEVVGFLRTAGPTLSPFNAW 259
Query 253 VFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGI 312
+FLKGLETLR+RM+AH +A LAEWL++ +E+VYYAGLP H HE A +QQ GFG +
Sbjct 260 LFLKGLETLRIRMQAHSASALALAEWLERQPGIERVYYAGLPSHPQHELARRQQSGFGAV 319
Query 313 VSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQEGL 372
VSF VKGGR+ AW+ ID T+ +SIT NLGD K+TI HPATT+HG+LSPE + AGI + L
Sbjct 320 VSFDVKGGRDAAWRFIDATRMVSITTNLGDTKTTIAHPATTSHGRLSPEDRARAGIGDSL 379
Query 373 IRVSVGLEDISDIIRDLDRGLALI 396
IRV+VGLED+ D+ D+ RGLA +
Sbjct 380 IRVAVGLEDLDDLKADMARGLAAL 403
>Q8L0X4 L-methionine gamma-lyase [Fusobacterium nucleatum subsp.
polymorphum]
Length=395
Score = 343 bits (881), Expect = 1e-119
Identities = 164/391 (42%), Positives = 267/391 (68%), Gaps = 3/391 (1%)
Query 9 EYQLDTLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTV 68
+Y L T AI G ++ G A PI+ TS+F++++A + +F+ E +G IY+R NPT
Sbjct 5 KYGLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTT 64
Query 69 AMFEKRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAK 128
+ E ++AA++ E AVATSSGMGA+ S LKAGDHV+ + ++G AL + +
Sbjct 65 TVLENKIAALEEGEAAVATSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMCHGLTR 124
Query 129 FAVDITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAH-NAMLVVD 187
F +++TFVD ++LD KNAM+ T+++++E+P+NP +I D+ AL+++AH + N +++VD
Sbjct 125 FGIEVTFVDTSNLDEVKNAMKKNTRVVYLETPANPNLKIVDLEALSKLAHTNPNTLVIVD 184
Query 188 NSFCTPALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPS 245
N+F TP +Q+PLKLGAD+V++S TKYI+G G + G V + +L +++ G+ G
Sbjct 185 NTFATPYMQKPLKLGADIVVHSVTKYINGHGDVIAGLVITNKELADQIRFIGLKDMTGAV 244
Query 246 MSPFNAWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQ 305
+ P +A+ ++G++T +RM+ HC+NA+++ E+L++H +E+VYY GL H GHE A KQ
Sbjct 245 LGPQDAYYIIRGMKTFEIRMERHCKNAKKVVEFLNKHPKIERVYYPGLETHPGHEIAKKQ 304
Query 306 QQGFGGIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQA 365
+ FG ++SF +KGG E +++N + S+ +LGD ++ I HPA+ TH + E ++A
Sbjct 305 MKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREA 364
Query 366 AGIQEGLIRVSVGLEDISDIIRDLDRGLALI 396
AGI +GL+R+SVGLE++ DII DL++GL I
Sbjct 365 AGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
>P9WGB5 O-succinylhomoserine sulfhydrylase [Mycobacterium tuberculosis
(strain ATCC 25618 / H37Rv)]
Length=406
Score = 338 bits (866), Expect = 4e-117
Identities = 173/386 (45%), Positives = 256/386 (66%), Gaps = 5/386 (1%)
Query 14 TLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEK 73
T+ +R G RS E AE ++LTS +VY +AA A F+GE+ +YSR+ NPTV++FE+
Sbjct 21 TVGVRGGMLRSGFEETAEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEE 80
Query 74 RLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDI 133
RL ++GA A AT+SGM A+ + A L AGD ++ +R++FGS + + + ++ V
Sbjct 81 RLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQT 140
Query 134 TFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCTP 193
FVD +DL W+ A+ T+ +F E+PSNP+ + DI A+ E+AHA A +V+DN F TP
Sbjct 141 VFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATP 200
Query 194 ALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLE-EVFGVVRTLGPSMSPFNAW 252
LQQ LG D+V+YS TK+IDGQGR LGGA+ G + ++ V ++R GP+MS FNAW
Sbjct 201 LLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAW 260
Query 253 VFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGI 312
V LKGLETL +R++ +AQ++AE+L+ H +V V Y LP H ++ A +Q G G +
Sbjct 261 VLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTV 320
Query 313 VSFVV----KGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGI 368
V+F + ++ A++V+D + I I+ NLGD KS +THPATTTH + PE + A G+
Sbjct 321 VTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGL 380
Query 369 QEGLIRVSVGLEDISDIIRDLDRGLA 394
+G++R+SVGLED D+I D+DR L+
Sbjct 381 GDGVVRISVGLEDTDDLIADIDRALS 406
Score = 18.9 bits (37), Expect = 3.7
Identities = 9/20 (45%), Positives = 12/20 (60%), Gaps = 0/20 (0%)
Query 12 LDTLAIRTGHTRSFEGEHAE 31
L+TLAIR H+ + AE
Sbjct 266 LETLAIRVQHSNASAQRIAE 285
>P9WGB4 O-succinylhomoserine sulfhydrylase [Mycobacterium tuberculosis
(strain CDC 1551 / Oshkosh)]
Length=406
Score = 338 bits (866), Expect = 4e-117
Identities = 173/386 (45%), Positives = 256/386 (66%), Gaps = 5/386 (1%)
Query 14 TLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEK 73
T+ +R G RS E AE ++LTS +VY +AA A F+GE+ +YSR+ NPTV++FE+
Sbjct 21 TVGVRGGMLRSGFEETAEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEE 80
Query 74 RLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDI 133
RL ++GA A AT+SGM A+ + A L AGD ++ +R++FGS + + + ++ V
Sbjct 81 RLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQT 140
Query 134 TFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCTP 193
FVD +DL W+ A+ T+ +F E+PSNP+ + DI A+ E+AHA A +V+DN F TP
Sbjct 141 VFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATP 200
Query 194 ALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLE-EVFGVVRTLGPSMSPFNAW 252
LQQ LG D+V+YS TK+IDGQGR LGGA+ G + ++ V ++R GP+MS FNAW
Sbjct 201 LLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAW 260
Query 253 VFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGI 312
V LKGLETL +R++ +AQ++AE+L+ H +V V Y LP H ++ A +Q G G +
Sbjct 261 VLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTV 320
Query 313 VSFVV----KGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGI 368
V+F + ++ A++V+D + I I+ NLGD KS +THPATTTH + PE + A G+
Sbjct 321 VTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGL 380
Query 369 QEGLIRVSVGLEDISDIIRDLDRGLA 394
+G++R+SVGLED D+I D+DR L+
Sbjct 381 GDGVVRISVGLEDTDDLIADIDRALS 406
Score = 18.9 bits (37), Expect = 3.7
Identities = 9/20 (45%), Positives = 12/20 (60%), Gaps = 0/20 (0%)
Query 12 LDTLAIRTGHTRSFEGEHAE 31
L+TLAIR H+ + AE
Sbjct 266 LETLAIRVQHSNASAQRIAE 285
>Q8RDT4 L-methionine gamma-lyase [Fusobacterium nucleatum subsp.
nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP
101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)]
Length=395
Score = 333 bits (855), Expect = 1e-115
Identities = 160/388 (41%), Positives = 259/388 (67%), Gaps = 3/388 (1%)
Query 12 LDTLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMF 71
L T AI G ++ G A PI+ TS+F++++A + +F+ E +G IY+R NPT +
Sbjct 8 LGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVL 67
Query 72 EKRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAV 131
E ++AA++ E +A SSGMGA+ S LKAGDHV+ + ++G AL + +F V
Sbjct 68 ENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTRFGV 127
Query 132 DITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAH-NAMLVVDNSF 190
++TFVD ++L+ KNAM+ T+++++E+P+NP +I D+ AL++IAH + N +++VDN+F
Sbjct 128 EVTFVDTSNLEEVKNAMKKNTRVVYLETPANPNLKIVDLEALSKIAHTNPNTLVIVDNTF 187
Query 191 CTPALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPSMSP 248
TP +Q+PLKLG D+V++SATKY++G G + G V +L +++ G+ G + P
Sbjct 188 ATPYMQKPLKLGVDIVVHSATKYLNGHGDVIAGLVVTRQELADQIRFVGLKDMTGAVLGP 247
Query 249 FNAWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQG 308
A+ ++GL+T +RM+ HC+NA+ + ++L++H VEKVYY GL H G+E A KQ +
Sbjct 248 QEAYYIIRGLKTFEIRMERHCKNARTIVDFLNKHPKVEKVYYPGLETHPGYEIAKKQMKD 307
Query 309 FGGIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGI 368
FG ++SF +KGG E +++N + S+ +LGD ++ I HPA+ TH + E ++ AGI
Sbjct 308 FGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREVAGI 367
Query 369 QEGLIRVSVGLEDISDIIRDLDRGLALI 396
+GL+R+SVGLE++ DII DL++GL I
Sbjct 368 TDGLVRLSVGLENVEDIIADLEQGLEKI 395
>Q7MX71 L-methionine gamma-lyase [Porphyromonas gingivalis (strain
ATCC BAA-308 / W83)]
Length=399
Score = 318 bits (814), Expect = 2e-109
Identities = 159/383 (42%), Positives = 247/383 (64%), Gaps = 3/383 (1%)
Query 14 TLAIRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEK 73
T AI G + G A PI+ TS+FV++ A + +F+GE G IY+R NP E+
Sbjct 13 TRAIHGGAIENAFGCLATPIYQTSTFVFDTAEQGGRRFAGEEDGYIYTRLGNPNCTQVEE 72
Query 74 RLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDI 133
+LA ++G E A + SSG+GA+ S +KAGDH++ + ++G A ++++ V++
Sbjct 73 KLAMLEGGEAAASASSGIGAISSAIWVCVKAGDHIVAGKTLYGCTFAFLTHGLSRYGVEV 132
Query 134 TFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLV-VDNSFCT 192
T VD + + A+RP TK++++E+P+NP + DI A+ +IAH H + V VDN++CT
Sbjct 133 TLVDTRHPEEVEAAIRPNTKLVYLETPANPNMYLTDIKAVCDIAHKHEGVRVMVDNTYCT 192
Query 193 PALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPSMSPFN 250
P + +PL+LGAD+V++SATKY++G G + G V G ++EV GV G +MSPF+
Sbjct 193 PYICRPLELGADIVVHSATKYLNGHGDVIAGFVVGKEDYIKEVKLVGVKDLTGANMSPFD 252
Query 251 AWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFG 310
A++ +G++TL++RM+ HC NAQ +AE+L++H VE VY+ GLP +E A KQ G
Sbjct 253 AYLISRGMKTLQIRMEQHCRNAQTVAEFLEKHPAVEAVYFPGLPSFPQYELAKKQMALPG 312
Query 311 GIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQE 370
+++F VKGG E K+++N S+ +LGD ++ I HPA+ TH +PE + A+ I E
Sbjct 313 AMIAFEVKGGCEAGKKLMNNLHLCSLAVSLGDTETLIQHPASMTHSPYTPEERAASDISE 372
Query 371 GLIRVSVGLEDISDIIRDLDRGL 393
GL+R+SVGLE++ DII DL GL
Sbjct 373 GLVRLSVGLENVEDIIADLKHGL 395
>Q73KL7 L-methionine gamma-lyase [Treponema denticola (strain
ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)]
Length=401
Score = 313 bits (801), Expect = 2e-107
Identities = 153/381 (40%), Positives = 248/381 (65%), Gaps = 4/381 (1%)
Query 17 IRTGHTRSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEKRLA 76
I G ++ G A PI+ TS+F +++A + +F+ E G IY+R NPT + E++LA
Sbjct 16 IHAGSIKNKYGALATPIYQTSTFAFDSAEQGGRRFALEEEGYIYTRLGNPTTTVVEEKLA 75
Query 77 AMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDITFV 136
++ E ++ SSG+GA+ S + + AGDH++ + ++G A +++F VD+TFV
Sbjct 76 CLENGEACMSASSGIGAVTSCIWSIVNAGDHIVAGKTLYGCTFAFLNHGLSRFGVDVTFV 135
Query 137 DLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHN--AMLVVDNSFCTPA 194
D D + K A++P TK++++E+P+NP + DI A+++IAHAHN ++VDN++ TP
Sbjct 136 DTRDPENVKKALKPNTKIVYLETPANPNMYLCDIAAVSKIAHAHNPECKVIVDNTYMTPY 195
Query 195 LQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPSMSPFNAW 252
LQ+PL LGAD+V++SATKY++G G + G V G + +++V GV G ++ PF A+
Sbjct 196 LQRPLDLGADVVLHSATKYLNGHGDVIAGFVVGKKEFIDQVRFVGVKDMTGSTLGPFEAY 255
Query 253 VFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGI 312
+ +G++TL +RM+ HC NAQ++AE+L++H VE + + GL +E A KQ + G +
Sbjct 256 LIGRGMKTLDIRMEKHCANAQKVAEFLEKHPAVESIAFPGLKSFPQYELAKKQMKLCGAM 315
Query 313 VSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQEGL 372
++F VKGG E +I++ +F +I +LGD ++ I HPA+ TH +PE + A+ I EGL
Sbjct 316 IAFTVKGGLEAGKTLINSVKFATIAVSLGDAETLIQHPASMTHSPYTPEERAASDIAEGL 375
Query 373 IRVSVGLEDISDIIRDLDRGL 393
+R+SVGLED DII DL + L
Sbjct 376 VRLSVGLEDAEDIIADLKQAL 396
>P13254 L-methionine gamma-lyase [Pseudomonas putida]
Length=398
Score = 295 bits (754), Expect = 2e-100
Identities = 153/383 (40%), Positives = 233/383 (61%), Gaps = 3/383 (1%)
Query 14 TLAIRTGHT-RSFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFE 72
T AI G+ + G P++ T++F + AA F+GE +G+ YSR +NPT+ + E
Sbjct 12 TRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLE 71
Query 73 KRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVD 132
R+A+++G E +A +SGMGA+ S L+ GD V+ ++G A + +F V
Sbjct 72 ARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVK 131
Query 133 ITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCT 192
+ VD+ DL A + AM P T++++ ESP+NP +ADI +A+IA H A +VVDN++CT
Sbjct 132 LRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYCT 191
Query 193 PALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPSMSPFN 250
P LQ+PL+LGADLV++SATKY+ G G G V GS L++ + G+ G +SP +
Sbjct 192 PYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLSPHD 251
Query 251 AWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFG 310
A + ++G++TL LRM HC NAQ LAE+L + VE ++Y GL + A +Q G
Sbjct 252 AALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPG 311
Query 311 GIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQE 370
G+++F +KGG + ++ Q S +LGD +S HPA+ TH +PE + GI E
Sbjct 312 GMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISE 371
Query 371 GLIRVSVGLEDISDIIRDLDRGL 393
GL+R+SVGLEDI D++ D+ + L
Sbjct 372 GLVRLSVGLEDIDDLLADVQQAL 394
>A0A0J6G7P5 L-methionine gamma-lyase [Pseudomonas deceptionensis]
Length=399
Score = 283 bits (723), Expect = 1e-95
Identities = 146/388 (38%), Positives = 235/388 (61%), Gaps = 4/388 (1%)
Query 10 YQLDTLAIRTGHTR-SFEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTV 68
+ T AI G+ G P+++TS+F + A F+GE SG+ Y+R +NPT+
Sbjct 8 FGFSTRAIHYGYNALENNGALIPPVYMTSTFAFPTVEYGAGCFAGEESGHFYTRISNPTL 67
Query 69 AMFEKRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAK 128
A+ E R+AA++ E VA SSGMGA+ + L+ GD +I +R ++G AL + +
Sbjct 68 ALLESRMAALENGEAGVAFSSGMGAIAATFWTLLRPGDEIIVNRTLYGCTFALLHHGIGE 127
Query 129 FAVDITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVV-D 187
F V + VD+++L + A+ P T+M++ E+P+NP ++ DI A++ IAH HN ++VV D
Sbjct 128 FGVVVKHVDMSNLAELEAAIGPATRMIYFETPANPNMQLVDIAAVSAIAHTHNDLIVVID 187
Query 188 NSFCTPALQQPLKLGADLVMYSATKYIDGQGRALGGAVTGSHKLLEEV--FGVVRTLGPS 245
N++CTP LQ+PL+LGAD+V++SATKY+ G G V L + + G+ G
Sbjct 188 NTYCTPYLQRPLELGADVVVHSATKYLSGHSDITAGVVVTRQSLADRIRLQGLKDLTGAV 247
Query 246 MSPFNAWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQ 305
+SP +A + ++G++TL LRM HC +AQ +A+ L H VE V Y GLP + A++Q
Sbjct 248 LSPHDAHLLMRGIKTLALRMDRHCSSAQVIAQMLQDHPAVEWVAYPGLPSFPQYALASRQ 307
Query 306 QQGFGGIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQA 365
+ GG+++F +KGG + ++ Q S +LG +S HPA+ TH + E +
Sbjct 308 MKLPGGMIAFELKGGMAAGQRFMNALQLFSRAVSLGGAESLAQHPASMTHSTYTLEERAK 367
Query 366 AGIQEGLIRVSVGLEDISDIIRDLDRGL 393
GI EGL+R++VGLEDI+D++ D+++ +
Sbjct 368 HGISEGLVRLAVGLEDIADLLADIEQAM 395
>Q79VI4 O-acetyl-L-homoserine sulfhydrylase [Corynebacterium glutamicum
(strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM
1318 / LMG 3730 / NCIMB 10025)]
Length=437
Score = 276 bits (707), Expect = 8e-93
Identities = 151/405 (37%), Positives = 237/405 (59%), Gaps = 42/405 (10%)
Query 32 PIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEKRLAAMDGAERAVATSSGM 91
PI+ +++FV+++A A +F+ E G +YSR TNPTV E R+A+++G AVA SSG
Sbjct 35 PIYQSTAFVFDSAEHAKQRFALEDLGPVYSRLTNPTVEALENRIASLEGGVHAVAFSSGQ 94
Query 92 GALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDITFVDL-NDLDAWKNAMRP 150
A + + AGDH++ S ++G LF + + +D++FV+ +D ++W+ A++P
Sbjct 95 AATTNAILNLAGAGDHIVTSPRLYGGTETLFLITLNRLGIDVSFVENPDDPESWQAAVQP 154
Query 151 ETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCTPALQQPLKLGADLVMYSA 210
TK F E+ +NP A++ DIPA+AE+AH ++ L++DN+ T AL +PL+LGAD+V+ S
Sbjct 155 NTKAFFGETFANPQADVLDIPAVAEVAHRNSVPLIIDNTIATAALVRPLELGADVVVASL 214
Query 211 TKYIDGQGRALGGAVTGSHKL------------------------------------LEE 234
TK+ G G LGG + K L+
Sbjct 215 TKFYTGNGSGLGGVLIDGGKFDWTVEKDGKPVFPYFVTPDAAYHGLKYADLGAPAFGLKV 274
Query 235 VFGVVRTLGPSMSPFNAWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLP 294
G++R G ++S FNAW ++G++TL LR++ H ENA ++AE+L+ H+ VEKV +AGL
Sbjct 275 RVGLLRDTGSTLSAFNAWAAVQGIDTLSLRLERHNENAIKVAEFLNNHEKVEKVNFAGLK 334
Query 295 QHIGHERATKQQQGF---GGIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPA 351
+ ATK++ G G +++F +KGG++ AW ID + S N+GDV+S + HPA
Sbjct 335 DSPWY--ATKEKLGLKYTGSVLTFEIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPA 392
Query 352 TTTHGKLSPEAKQAAGIQEGLIRVSVGLEDISDIIRDLDRGLALI 396
TTTH + AG+ + +R+SVG+E I DII DL+ G A I
Sbjct 393 TTTHSQSDEAGLARAGVTQSTVRLSVGIETIDDIIADLEGGFAAI 437
>Q83A83 Cystathionine beta-lyase [Coxiella burnetii (strain RSA
493 / Nine Mile phase I)]
Length=387
Score = 269 bits (687), Expect = 2e-90
Identities = 152/393 (39%), Positives = 229/393 (58%), Gaps = 13/393 (3%)
Query 5 NDELEYQLDTLAIRTGHTRS-FEGEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRF 63
N+ + +DT I G G PI+ S++ A K G G YSR
Sbjct 4 NNNKKSHIDTRVIHAGQKPDPLTGAVMTPIYTASTY--------AQKSPGVHQGYEYSRS 55
Query 64 TNPTVAMFEKRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFE 123
NPT +E+ +A ++ + A +SGM A ++ + L+ GDHV+ V+G LFE
Sbjct 56 QNPTRFAYERCVADLESGQHGFAFASGMAATATI-LELLQPGDHVVVMDDVYGGSYRLFE 114
Query 124 KYVAKFA-VDITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNA 182
+ A + +FVD D + + A+ +TKML++ESPSNP +I D+ +AEIA N
Sbjct 115 NVRKRSAGLSFSFVDFTDENKVREAVTAKTKMLWVESPSNPRLKIVDLAKIAEIAKEKNI 174
Query 183 MLVVDNSFCTPALQQPLKLGADLVMYSATKYIDGQGRALGG-AVTGSHKLLEEVFGVVRT 241
+ V DN+F TP +Q+PL+LG D+V +SATKY++G +GG AV G +K L E ++
Sbjct 175 IAVADNTFATPIIQRPLELGFDIVTHSATKYLNGHSDIIGGVAVVGDNKTLAEQLKYLQN 234
Query 242 -LGPSMSPFNAWVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHE 300
+G +PF++++ L+GL+TL +RM+ HCENA QLA+WL++H V++VYY GLP H H
Sbjct 235 AIGAIAAPFDSFMVLRGLKTLAIRMERHCENAMQLAQWLEKHPKVKRVYYPGLPSHPQHS 294
Query 301 RATKQQQGFGGIVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSP 360
A KQ + FGG++S +K KV++ Q ++ +LG V+S I HPA TH +
Sbjct 295 IAKKQMRYFGGMISVELKCDLNETKKVLERCQLFTLAESLGGVESLIEHPAIMTHASIPQ 354
Query 361 EAKQAAGIQEGLIRVSVGLEDISDIIRDLDRGL 393
+Q GI +G IR+SVG+E I+D+ DL+ L
Sbjct 355 AERQKLGITDGFIRLSVGIEAITDLRHDLEAAL 387
>A2RM21 Cystathionine beta-lyase [Lactococcus lactis subsp. cremoris
(strain MG1363)]
Length=380
Score = 263 bits (671), Expect = 4e-88
Identities = 146/369 (40%), Positives = 222/369 (60%), Gaps = 13/369 (4%)
Query 27 GEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEKRLAAMDGAERAVA 86
G + PI+ TS++ G+ YSR NPT E+ +A ++G + A
Sbjct 20 GAVSVPIYQTSTYKQNGL--------GQPKEYEYSRSGNPTRHALEELIADLEGGVQGFA 71
Query 87 TSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDITFVDLNDLDAWKN 146
SSG+ + +V F AGDH+I + V+G L +K + K + VDL++LD K
Sbjct 72 FSSGLAGIHAVLSLF-SAGDHIILADDVYGGTFRLMDKVLTKTGIIYDLVDLSNLDDLKA 130
Query 147 AMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCTPALQQPLKLGADLV 206
A + ETK ++ E+PSNPL ++ DI ++ IA AH+A+ +VDN+F TP LQQP+ LGAD+V
Sbjct 131 AFKEETKAIYFETPSNPLLKVLDIKEISAIAKAHDALTLVDNTFATPYLQQPIALGADIV 190
Query 207 MYSATKYIDGQGRALGGAV-TGSHKLLEEVFGVVRTLGPSMSPFNAWVFLKGLETLRLRM 265
++SATKY+ G + G V T S +L E+ + ++G + P ++W+ +G++TL LRM
Sbjct 191 LHSATKYLGGHSDVVAGLVTTNSKELASEIGFLQNSIGAVLGPQDSWLVQRGIKTLALRM 250
Query 266 KAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGIVSFVVKGGREGAW 325
+AH NAQ++AE+L+ K V KVYY GL H GHE A KQ FGG++SF + E A
Sbjct 251 EAHSANAQKIAEFLETSKAVSKVYYPGLNSHPGHEIAKKQMSAFGGMISFELTD--ENAV 308
Query 326 K-VIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQEGLIRVSVGLEDISD 384
K ++N + ++ +LG V+S I PA TH + E ++ GI++GLIR+SVG+E I D
Sbjct 309 KDFVENLSYFTLAESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEAIED 368
Query 385 IIRDLDRGL 393
++ D+ L
Sbjct 369 LLTDIKEAL 377
>P9WGB7 Cystathionine gamma-synthase [Mycobacterium tuberculosis
(strain ATCC 25618 / H37Rv)]
Length=388
Score = 261 bits (667), Expect = 2e-87
Identities = 146/363 (40%), Positives = 217/363 (60%), Gaps = 11/363 (3%)
Query 32 PIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFEKRLAAMDGAERAVATSSGM 91
PI+ +S+F + F Y+R NPT A E LAA++ A A SSGM
Sbjct 35 PIYASSTFAQDGVGGLRGGFE-------YARTGNPTRAALEASLAAVEEGAFARAFSSGM 87
Query 92 GALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVDITFVDLNDLDAWKNAMRPE 151
A A L+ GDHV+ +G L +K ++ V T V L DLDA A+ P
Sbjct 88 AATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPR 147
Query 152 TKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCTPALQQPLKLGADLVMYSAT 211
T+++++E+P+NPL IADI A+AE+ +A ++VDN+F +PALQQPL+LGAD+V++S T
Sbjct 148 TRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTT 207
Query 212 KYIDGQGRALGGAVTGSHKLLEEVFGVVRT-LGPSMSPFNAWVFLKGLETLRLRMKAHCE 270
KYI G +GGA+ + + L+E F ++ G PF+A++ ++GL+TL LRM+ H E
Sbjct 208 KYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSE 267
Query 271 NAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGGIVSFVVKGGREGAWKVIDN 330
NA +AE+L H +V V Y GLP H GHE A +Q +GFGG+VS ++ GR A +
Sbjct 268 NACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAK 327
Query 331 TQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQEGLIRVSVGLEDISDIIRDLD 390
T+ + +LG V+S I HP+ TH + A + + L+R+SVG+EDI+D++ DL+
Sbjct 328 TRVFILAESLGGVESLIEHPSAMTH---ASTAGSQLEVPDDLVRLSVGIEDIADLLGDLE 384
Query 391 RGL 393
+ L
Sbjct 385 QAL 387
>O05394 Cystathionine gamma-lyase [Bacillus subtilis (strain 168)]
Length=379
Score = 259 bits (663), Expect = 6e-87
Identities = 146/382 (38%), Positives = 225/382 (59%), Gaps = 12/382 (3%)
Query 14 TLAIRTGHTRSFE-GEHAEPIFLTSSFVYENAAEAAAKFSGEVSGNIYSRFTNPTVAMFE 72
TL I G T + G + PI+ S++ A G+ +G YSR NPT E
Sbjct 5 TLMIHGGITGDEKTGAVSVPIYQVSTYKQPKA--------GQHTGYEYSRTANPTRTALE 56
Query 73 KRLAAMDGAERAVATSSGMGALLSVCMAFLKAGDHVICSRAVFGSIVALFEKYVAKFAVD 132
+ ++ E A SSGM A+ +V M F +GDHV+ + V+G + K + + ++
Sbjct 57 ALVTELESGEAGYAFSSGMAAITAVMMLF-NSGDHVVLTDDVYGGTYRVMTKVLNRLGIE 115
Query 133 ITFVDLNDLDAWKNAMRPETKMLFIESPSNPLAEIADIPALAEIAHAHNAMLVVDNSFCT 192
TFVD + + + A+RP TK ++IE+P+NPL +I D+ +A+IA +L+VDN+F T
Sbjct 116 STFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIAKKAGVLLIVDNTFNT 175
Query 193 PALQQPLKLGADLVMYSATKYIDGQGRALGG-AVTGSHKLLEEVFGVVRTLGPSMSPFNA 251
P QQPL LGAD+V++SATKY+ G +GG VT S +L EE+ V + G + P ++
Sbjct 176 PYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDS 235
Query 252 WVFLKGLETLRLRMKAHCENAQQLAEWLDQHKNVEKVYYAGLPQHIGHERATKQQQGFGG 311
W+ ++G++TL LRM+A +NA+++A +L+ H V+ +YY G H GHE A Q GFGG
Sbjct 236 WLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPGSSNHPGHELAKTQGAGFGG 295
Query 312 IVSFVVKGGREGAWKVIDNTQFISITGNLGDVKSTITHPATTTHGKLSPEAKQAAGIQEG 371
++SF + G E + N + +I +LG V+S I+ PA TH + E + GI +G
Sbjct 296 MISFDI-GSEERVDAFLGNLKLFTIAESLGAVESLISVPARMTHASIPRERRLELGITDG 354
Query 372 LIRVSVGLEDISDIIRDLDRGL 393
LIR+SVG+ED D++ D+ + L
Sbjct 355 LIRISVGIEDAEDLLEDIGQAL 376
Lambda K H a alpha
0.320 0.135 0.394 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1700676
Database: e39dffb2a1b04b36e6398e858a7bc1ac.SwissProt.fasta
Posted date: May 29, 2024 11:31 AM
Number of letters in database: 5,573
Number of sequences in database: 14
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
