BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: bc6a80d283e6b41ef7d8d28a8d5ee003.SwissProt.fasta
           17 sequences; 5,585 total letters



Query= ACIAD2316

Length=291
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium bark...  160     1e-50
P0ABQ3 2-hydroxy-3-oxopropionate reductase [Escherichia coli O6:H...  139     7e-43
P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str...  139     7e-43
O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigi...  134     7e-41
Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial...  134     1e-40
Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aerugino...  134     1e-40
Q55702 Uncharacterized oxidoreductase slr0229 [Synechocystis sp. ...  132     5e-40
O34948 Uncharacterized oxidoreductase YkwC [Bacillus subtilis (st...  129     4e-39
P9WNY5 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium...  119     3e-35
P9WNY4 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium...  119     3e-35
P63936 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium...  119     3e-35
P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str...  119     5e-35
P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa...  119     6e-35
P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo sa...  107     2e-30
P0A9V8 3-sulfolactaldehyde reductase [Escherichia coli (strain K12)]  105     6e-30
Q49A26 Cytokine-like nuclear factor N-PAC [Homo sapiens]              106     3e-29
Q922P9 Cytokine-like nuclear factor N-PAC [Mus musculus]              105     1e-28


>Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium 
barkeri]
Length=301

 Score = 160 bits (404),  Expect = 1e-50
 Identities = 104/293 (35%), Positives = 152/293 (52%), Gaps = 10/293 (3%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAVQA--DIIF  62
            + FIGLGAMG  MA +L +   TVY ++   E         G QA E +Q V A  DIIF
Sbjct  7    IGFIGLGAMGKPMAINLLKEGVTVYAFDL-MEANVAAVVAQGAQACENNQKVAAASDIIF  65

Query  63   SCLPTSADVAQLVEN------LELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPV  116
            + LP +A + + V N         K GT+ VD +S  P    ++      +G+DY+DAPV
Sbjct  66   TSLP-NAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPV  124

Query  117  SGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVN  176
            SG T GA+  TLT+MVG     FE+  P +   GK I HVG++GAG AVK VNN+LL  N
Sbjct  125  SGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLLGCN  184

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKD  236
            + S+AE        G+      + I  SSG+S   E    + +++  F   FA+ L  KD
Sbjct  185  MASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKFIMSGDFAGGFAMDLQHKD  244

Query  237  AGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMYESWSKITL  289
             G+AL+      +P P+ A+   + +          D SA +K++E  + +++
Sbjct  245  LGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIKVWEQMTGVSV  297


>P0ABQ3 2-hydroxy-3-oxopropionate reductase [Escherichia coli 
O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=294

 Score = 139 bits (351),  Expect = 7e-43
 Identities = 98/290 (34%), Positives = 146/290 (50%), Gaps = 9/290 (3%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAV--QADIIF  62
            V FIGLG MG  M+ +L +   ++ V +R+ E A       G +    ++A+  Q D+I 
Sbjct  3    VGFIGLGIMGKPMSKNLLKAGYSLVVADRNPE-AIADVIAAGAETASTAKAIAEQCDVII  61

Query  63   SCLPTSADVAQLV--ENLEL---KPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            + LP S  V ++   EN  +   KPGT+ +D +S  P  +R++   LK +G+D LDAPVS
Sbjct  62   TMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVS  121

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNL  177
            G    A + TL+VMVGGD   F++ Y  M+A    + H GE GAG   K  N +++A+N+
Sbjct  122  GGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNI  181

Query  178  WSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKDA  237
             +++E  T     GVN       I      S V +   P  V++R+F   F + L  KD 
Sbjct  182  AAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPM-VMDRNFKPGFRIDLHIKDL  240

Query  238  GIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMYESWSKI  287
              ALD  H      PL A    ++QA        +D SA    YE  +K+
Sbjct  241  ANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKV  290


>P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli 
(strain K12)]
Length=294

 Score = 139 bits (351),  Expect = 7e-43
 Identities = 98/290 (34%), Positives = 146/290 (50%), Gaps = 9/290 (3%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAV--QADIIF  62
            V FIGLG MG  M+ +L +   ++ V +R+ E A       G +    ++A+  Q D+I 
Sbjct  3    VGFIGLGIMGKPMSKNLLKAGYSLVVADRNPE-AIADVIAAGAETASTAKAIAEQCDVII  61

Query  63   SCLPTSADVAQLV--ENLEL---KPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            + LP S  V ++   EN  +   KPGT+ +D +S  P  +R++   LK +G+D LDAPVS
Sbjct  62   TMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVS  121

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNL  177
            G    A + TL+VMVGGD   F++ Y  M+A    + H GE GAG   K  N +++A+N+
Sbjct  122  GGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNI  181

Query  178  WSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKDA  237
             +++E  T     GVN       I      S V +   P  V++R+F   F + L  KD 
Sbjct  182  AAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPM-VMDRNFKPGFRIDLHIKDL  240

Query  238  GIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMYESWSKI  287
              ALD  H      PL A    ++QA        +D SA    YE  +K+
Sbjct  241  ANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKV  290


>O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigidimarina 
(strain NCIMB 400)]
Length=291

 Score = 134 bits (337),  Expect = 7e-41
 Identities = 92/289 (32%), Positives = 146/289 (51%), Gaps = 11/289 (4%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQ--AVQADIIF  62
            VAFIGLG MG+ MA HL +    V V+NR+  KA Q   +YG +  +  +  A   DI+F
Sbjct  4    VAFIGLGVMGFPMAGHLVKQGHDVTVYNRTGAKATQWVEQYGGKKADTPKDAAQGQDIVF  63

Query  63   SCLPTSADVAQLVENLE-----LKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            +C+    D+ Q+V         +  G I VD T+   D+AR++   ++   + +LDAPVS
Sbjct  64   TCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLDAPVS  123

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNL  177
            G   GA+N  LTVM+GGD   F+   P + A+ +  + +G  GAG   K VN + +A  +
Sbjct  124  GGQAGAENGALTVMMGGDQAHFDTVKPVISAYSRCAELLGPVGAGQLTKMVNQICIAGVV  183

Query  178  WSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKDA  237
              +AEG    K+ G++  + ++ I+  + +S   E  + + +    +   FA+  + KD 
Sbjct  184  QGLAEGLHFAKSAGLDGLKVIEVISKGAAQSWQMENRY-KTMWQGQYDFGFAIDWMRKDL  242

Query  238  GIALDLVHAAKLPAPLIALTQ---SLIQAANQTAEENSDFSAAVKMYES  283
            GIALD         P+ AL     S +QA      + S   A ++   S
Sbjct  243  GIALDEARRNGSHLPVAALVDQFYSEVQAMKGNRWDTSSLLARLEKSRS  291


>Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial 
[Drosophila melanogaster]
Length=324

 Score = 134 bits (338),  Expect = 1e-40
 Identities = 86/283 (30%), Positives = 143/283 (51%), Gaps = 10/283 (4%)

Query  3    QSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQ-AVQADII  61
            +++ F+GLG MG  MAS+L +    ++V++ S       A +  T   + S+ A  +D +
Sbjct  29   KNIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYAKTSELAKNSDFV  88

Query  62   FSCLPTSADVAQLVENLE---LKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVSG  118
             + LP +A V    + +    +   TI++D ++  PDL + L  ++  +G  ++DAPVSG
Sbjct  89   ITMLPNNAIVDASYDEMTADGVNKDTIFIDSSTISPDLVKSLQKKISAKGARFIDAPVSG  148

Query  119  QTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNLW  178
               GA+ ATLT MVGG    +      ++  GK I H G  G G A K  NNM+LA+++ 
Sbjct  149  GVPGAEQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNMMLAISMI  208

Query  179  SVAEGFTTLKAHGVNLGEALDCINASSGKSGVTET------IFPQRVLNRSFPVTFALPL  232
             V+E        G++     + IN+S+G+   +E       + P    NR +   F+  L
Sbjct  209  GVSEAMNLAVRQGLDANVFAEIINSSTGRCWASEIYNPVPGVCPSAPANRDYAGGFSSAL  268

Query  233  LAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFS  275
            + KD G+A  + +A+  P PL +L   + Q+       N DFS
Sbjct  269  ITKDLGLASGVANASNSPIPLGSLAHKVYQSLCDKGLGNKDFS  311


>Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aeruginosa 
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298

 Score = 134 bits (336),  Expect = 1e-40
 Identities = 95/293 (32%), Positives = 141/293 (48%), Gaps = 12/293 (4%)

Query  2    IQSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAVQ-ADI  60
            ++ +AFIGLG MG  MA++L +    + V++              + A     AVQ AD+
Sbjct  1    MKQIAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGASAARSARDAVQGADV  60

Query  61   IFSCLPTSADVAQLVEN-----LELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAP  115
            + S LP S  V  L  +       + PGT+ ++C++  P  AR++    + +G+  LDAP
Sbjct  61   VISMLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAP  120

Query  116  VSGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAV  175
            VSG T GA   TLT MVGGD  A E+A P  +A G+ I H G  GAG   K  NN LLAV
Sbjct  121  VSGGTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAV  180

Query  176  NLWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFP------QRVLNRSFPVTFA  229
             +   AE      A+G+      + +  SSG +   E   P          +R +   F 
Sbjct  181  LMIGTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPWPGVMENAPASRDYSGGFM  240

Query  230  LPLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMYE  282
              L+AKD G+A +   A+    P+ +L  SL +   +      DFS   K+++
Sbjct  241  AQLMAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQKLFD  293


>Q55702 Uncharacterized oxidoreductase slr0229 [Synechocystis 
sp. (strain PCC 6803 / Kazusa)]
Length=290

 Score = 132 bits (331),  Expect = 5e-40
 Identities = 90/288 (31%), Positives = 140/288 (49%), Gaps = 11/288 (4%)

Query  2    IQSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAK-QHATEYGTQAVE--LSQAVQA  58
            +  +A  GLG MG  MA +L ++      +NR+ E+   Q A + G + V      A  A
Sbjct  3    VSKIAVFGLGVMGSPMAQNLVKNGYQTVGYNRTLERPSVQEAAKAGVKVVTSIAVAAANA  62

Query  59   DIIFSCLPTSADVAQLVENLE-----LKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLD  113
            DII +C+    DV QL+          KP  + +DC++     A +L T LK QG+ +LD
Sbjct  63   DIILTCVGDEKDVQQLILGSGGIAEYAKPQALIIDCSTIGKTAAYELATNLKLQGLRFLD  122

Query  114  APVSGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLL  173
            APV+G  +GA N TLT+MVGGD + FE A P +++ G+ I H G SG+G AVK  N +L 
Sbjct  123  APVTGGDVGAINGTLTIMVGGDISDFEEALPVLKSIGEKIVHCGPSGSGQAVKLCNQVLC  182

Query  174  AVNLWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLL  233
             ++  + AE     +  G+     +D   + +  S     + P ++    F   F +  L
Sbjct  183  GIHAIAAAEAIQLSEQLGIAPELVIDTCGSGAAGSWALTNLAP-KMSEADFAPGFMVKHL  241

Query  234  AKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMY  281
             KD  +  +   A   P P + L +SL  +      E+    A ++ Y
Sbjct  242  LKDLRLVREA--AENGPLPGVTLAESLFTSVQLLGGEDQGSQAIIRAY  287


>O34948 Uncharacterized oxidoreductase YkwC [Bacillus subtilis 
(strain 168)]
Length=288

 Score = 129 bits (325),  Expect = 4e-39
 Identities = 92/291 (32%), Positives = 141/291 (48%), Gaps = 15/291 (5%)

Query  1    MIQSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAK---QHATEYGTQAVELSQAVQ  57
            M +++ FIGLG MG  MASH+      V V+ R+ EKA+   Q    +     +LS+  +
Sbjct  1    MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQKGAIWKDTVKDLSK--E  58

Query  58   ADIIFSCLPTSADVAQ-------LVENLELKPGTIWVDCTSGVPDLARQLVTQLKNQGVD  110
            AD+I + +   +DV +       ++EN   K G   +D T+  P LA+++    K + + 
Sbjct  59   ADVIITMVGYPSDVEEVYFGSNGIIENA--KEGAYLIDMTTSKPSLAKKIAEAAKEKALF  116

Query  111  YLDAPVSGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNN  170
             LDAPVSG  IGA N TL +MVGG+  AFE   P     G+ I++ G +G+G   K  N 
Sbjct  117  ALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQYQGPAGSGQHTKMCNQ  176

Query  171  MLLAVNLWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFAL  230
            + +A  +  VAE     +  G+     L  I   +  S     + P R+L  +F   F +
Sbjct  177  IAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLSNLAP-RMLQGNFEPGFYV  235

Query  231  PLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMY  281
                KD GIAL+         P ++L +SL        EENS   +  K++
Sbjct  236  KHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEENSGTQSIYKLW  286


>P9WNY5 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=294

 Score = 119 bits (299),  Expect = 3e-35
 Identities = 90/288 (31%), Positives = 138/288 (48%), Gaps = 18/288 (6%)

Query  4    SVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAV-----QA  58
            ++AF+GLG MG  M+++L      V    R F+ A   A+      V + ++      +A
Sbjct  3    TIAFLGLGNMGAPMSANLVGAGHVV----RGFDPAPTAASGAAAHGVAVFRSAPEAVAEA  58

Query  59   DIIFSCLPTSADVAQLVENL--ELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPV  116
            D++ + LPT   V +   ++    +P T+++D ++     AR++    ++ G+  LDAPV
Sbjct  59   DVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPV  118

Query  117  SGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVN  176
            SG   GA  ATL  MVGGD +   RA P ++     I H G +GAG A K  NNM+LAV 
Sbjct  119  SGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQ  178

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTET------IFPQRVLNRSFPVTFAL  230
              ++AE F   +  G++     D I  ++G      T        P    N  F   F+ 
Sbjct  179  QIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFST  238

Query  231  PLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAV  278
             L+ KD G+A+D V A    APL +     I A       + DFSA +
Sbjct  239  ALMNKDLGLAMDAVAATGATAPLGSHAAD-IYAKFAADHADLDFSAVI  285


 Score = 17.7 bits (34),  Expect = 5.8
 Identities = 7/23 (30%), Positives = 13/23 (57%), Gaps = 0/23 (0%)

Query  101  VTQLKNQGVDYLDAPVSGQTIGA  123
            +T +   G+  + AP+S   +GA
Sbjct  1    MTTIAFLGLGNMGAPMSANLVGA  23


>P9WNY4 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium 
tuberculosis (strain CDC 1551 / Oshkosh)]
Length=294

 Score = 119 bits (299),  Expect = 3e-35
 Identities = 90/288 (31%), Positives = 138/288 (48%), Gaps = 18/288 (6%)

Query  4    SVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAV-----QA  58
            ++AF+GLG MG  M+++L      V    R F+ A   A+      V + ++      +A
Sbjct  3    TIAFLGLGNMGAPMSANLVGAGHVV----RGFDPAPTAASGAAAHGVAVFRSAPEAVAEA  58

Query  59   DIIFSCLPTSADVAQLVENL--ELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPV  116
            D++ + LPT   V +   ++    +P T+++D ++     AR++    ++ G+  LDAPV
Sbjct  59   DVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPV  118

Query  117  SGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVN  176
            SG   GA  ATL  MVGGD +   RA P ++     I H G +GAG A K  NNM+LAV 
Sbjct  119  SGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQ  178

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTET------IFPQRVLNRSFPVTFAL  230
              ++AE F   +  G++     D I  ++G      T        P    N  F   F+ 
Sbjct  179  QIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFST  238

Query  231  PLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAV  278
             L+ KD G+A+D V A    APL +     I A       + DFSA +
Sbjct  239  ALMNKDLGLAMDAVAATGATAPLGSHAAD-IYAKFAADHADLDFSAVI  285


 Score = 17.7 bits (34),  Expect = 5.8
 Identities = 7/23 (30%), Positives = 13/23 (57%), Gaps = 0/23 (0%)

Query  101  VTQLKNQGVDYLDAPVSGQTIGA  123
            +T +   G+  + AP+S   +GA
Sbjct  1    MTTIAFLGLGNMGAPMSANLVGA  23


>P63936 Probable 3-hydroxyisobutyrate dehydrogenase [Mycobacterium 
bovis (strain ATCC BAA-935 / AF2122/97)]
Length=294

 Score = 119 bits (299),  Expect = 3e-35
 Identities = 90/288 (31%), Positives = 138/288 (48%), Gaps = 18/288 (6%)

Query  4    SVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAV-----QA  58
            ++AF+GLG MG  M+++L      V    R F+ A   A+      V + ++      +A
Sbjct  3    TIAFLGLGNMGAPMSANLVGAGHVV----RGFDPAPTAASGAAAHGVAVFRSAPEAVAEA  58

Query  59   DIIFSCLPTSADVAQLVENL--ELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPV  116
            D++ + LPT   V +   ++    +P T+++D ++     AR++    ++ G+  LDAPV
Sbjct  59   DVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPV  118

Query  117  SGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVN  176
            SG   GA  ATL  MVGGD +   RA P ++     I H G +GAG A K  NNM+LAV 
Sbjct  119  SGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQ  178

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTET------IFPQRVLNRSFPVTFAL  230
              ++AE F   +  G++     D I  ++G      T        P    N  F   F+ 
Sbjct  179  QIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFST  238

Query  231  PLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAV  278
             L+ KD G+A+D V A    APL +     I A       + DFSA +
Sbjct  239  ALMNKDLGLAMDAVAATGATAPLGSHAAD-IYAKFAADHADLDFSAVI  285


 Score = 17.7 bits (34),  Expect = 5.8
 Identities = 7/23 (30%), Positives = 13/23 (57%), Gaps = 0/23 (0%)

Query  101  VTQLKNQGVDYLDAPVSGQTIGA  123
            +T +   G+  + AP+S   +GA
Sbjct  1    MTTIAFLGLGNMGAPMSANLVGA  23


>P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli 
(strain K12)]
Length=292

 Score = 119 bits (297),  Expect = 5e-35
 Identities = 93/286 (33%), Positives = 133/286 (47%), Gaps = 12/286 (4%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAVQ--ADIIF  62
            + FIGLG MG  MA +L R    ++V   +           G  +VE ++ V   +DIIF
Sbjct  3    LGFIGLGIMGTPMAINLARAGHQLHV--TTIGPVADELLSLGAVSVETARQVTEASDIIF  60

Query  63   SCLPTSADVAQLV--EN----LELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPV  116
              +P +  V +++  EN      LK  TI VD +S  P   ++   Q+   G DYLDAPV
Sbjct  61   IMVPDTPQVEEVLFGENGCTKASLKGKTI-VDMSSISPIETKRFARQVNELGGDYLDAPV  119

Query  117  SGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVN  176
            SG  IGA   TL++MVGGD   FER  P  +  GK I  VG +G G   K  N +++A+N
Sbjct  120  SGGEIGAREGTLSIMVGGDEAVFERVKPLFELLGKNITLVGGNGDGQTCKVANQIIVALN  179

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKD  236
            + +V+E        G +       +      S + E +  +R++ R+F   F + L  KD
Sbjct  180  IEAVSEALLFASKAGADPVRVRQALMGGFASSRILE-VHGERMIKRTFNPGFKIALHQKD  238

Query  237  AGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMYE  282
              +AL    A  L  P  A  Q L            D SA V+  E
Sbjct  239  LNLALQSAKALALNLPNTATCQELFNTCAANGGSQLDHSALVQALE  284


>P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa 
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298

 Score = 119 bits (297),  Expect = 6e-35
 Identities = 91/294 (31%), Positives = 139/294 (47%), Gaps = 20/294 (7%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVE--LSQAVQADIIF  62
            +AF+GLG MG  MA++L +    V V++    KA     E G Q  +  L     A+++ 
Sbjct  4    IAFLGLGNMGGPMAANLLKAGHRVNVFDLQ-PKAVLGLVEQGAQGADSALQCCEGAEVVI  62

Query  63   SCLPTSADVAQL-------VENLELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAP  115
            S LP    V  L       +  +  KP  + +DC++  P+ AR++      +G+  LDAP
Sbjct  63   SMLPAGQHVESLYLGDDGLLARVAGKP--LLIDCSTIAPETARKVAEAAAAKGLTLLDAP  120

Query  116  VSGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAV  175
            VSG   GA   TL+ +VGG    F RA P ++  G+ I H G+ GAG   K  NNMLL +
Sbjct  121  VSGGVGGARAGTLSFIVGGPAEGFARARPVLENMGRNIFHAGDHGAGQVAKICNNMLLGI  180

Query  176  NLWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTET------IFPQRVLNRSFPVTFA  229
             +   AE       +G++     + +  SSG +           + PQ   +  +   F 
Sbjct  181  LMAGTAEALALGVKNGLDPAVLSEVMKQSSGGNWALNLYNPWPGVMPQAPASNGYAGGFQ  240

Query  230  LPLLAKDAGIALDLVHAAKLPAPLIALTQSL--IQAANQTAEENSDFSAAVKMY  281
            + L+ KD G+AL    A +   PL AL ++L  + A      E  DFS+  K+Y
Sbjct  241  VRLMNKDLGLALANAQAVQASTPLGALARNLFSLHAQADAEHEGLDFSSIQKLY  294


>P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo 
sapiens]
Length=336

 Score = 107 bits (268),  Expect = 2e-30
 Identities = 83/285 (29%), Positives = 132/285 (46%), Gaps = 14/285 (5%)

Query  5    VAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVE--LSQAVQADIIF  62
            V FIGLG MG  MA +L +H   + +++  F  A +   + G Q V      A +AD I 
Sbjct  42   VGFIGLGNMGNPMAKNLMKHGYPLIIYD-VFPDACKEFQDAGEQVVSSPADVAEKADRII  100

Query  63   SCLPTSADVAQLVENL-----ELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            + LPTS +  +          ++K G++ +D ++  P ++++L  +++  G  ++DAPVS
Sbjct  101  TMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVS  160

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNL  177
            G    A +  LT MVGG    F  A   +   G  + + G  G G A K  NNMLLA+++
Sbjct  161  GGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISM  220

Query  178  WSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVT------FALP  231
               AE        G++       +N SSG+   ++T  P   +    P        F   
Sbjct  221  IGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTT  280

Query  232  LLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSA  276
            L+AKD G+A D   + K P  L +L   + +          DFS+
Sbjct  281  LMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSS  325


>P0A9V8 3-sulfolactaldehyde reductase [Escherichia coli (strain 
K12)]
Length=298

 Score = 105 bits (262),  Expect = 6e-30
 Identities = 81/283 (29%), Positives = 136/283 (48%), Gaps = 8/283 (3%)

Query  4    SVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAVQ-ADIIF  62
            ++AFIGLG MG  MAS+L +    + V++ + E  +    +  T A   +QA + A+ I 
Sbjct  3    AIAFIGLGQMGSPMASNLLQQGHQLRVFDVNAEAVRHLVDKGATPAANPAQAAKDAEFII  62

Query  63   SCLPTSADVAQLV--EN---LELKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            + LP    V  ++  EN     L    + +D ++  P    +L+  ++ +G   +D PV 
Sbjct  63   TMLPNGDLVRNVLFGENGVCEGLSTDALVIDMSTIHPLQTDKLIADMQAKGFSMMDVPVG  122

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNN-MLLAVN  176
              +  A   TL ++ GG     ERA P + A G  + + G  G G  VK +NN M +A+N
Sbjct  123  RTSANAITGTLLLLAGGTAEQVERATPILMAMGSELINAGGPGMGIRVKLINNYMSIALN  182

Query  177  LWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIFPQRVLNRSFPVTFALPLLAKD  236
              S AE     +A  +    A+  ++ ++   G   T +P +VL+      F + L  KD
Sbjct  183  ALS-AEAAVLCEALNLPFDVAVKVMSGTAAGKGHFTTSWPNKVLSGDLSPAFMIDLAHKD  241

Query  237  AGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVK  279
             GIALD+ +   +P PL A ++ +   A        D+SA ++
Sbjct  242  LGIALDVANQLHVPMPLGAASREVYSQARAAGRGRQDWSAILE  284


>Q49A26 Cytokine-like nuclear factor N-PAC [Homo sapiens]
Length=553

 Score = 106 bits (265),  Expect = 3e-29
 Identities = 80/291 (27%), Positives = 130/291 (45%), Gaps = 19/291 (7%)

Query  3    QSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAK---QHATEYGTQAVELSQAVQAD  59
            + + F+GLG MG  + S+L +   TV VWNR+ EK     Q     G    E+      D
Sbjct  268  KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVST--CD  325

Query  60   IIFSCLPTSADVAQLVENLE-----LKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDA  114
            I F+C+        LV         ++PG  +VD ++   D   +L   + ++G  +L+A
Sbjct  326  ITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEA  385

Query  115  PVSGQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLA  174
            PVSG    +++  L ++  GD   +E      QA GK    +GE G    +  + NM+  
Sbjct  386  PVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQG  445

Query  175  VNLWSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIF----PQRVLNRSFPVTFAL  230
              + ++AEG T  +  G +    LD +N      G   +IF     Q +L  +F   F L
Sbjct  446  SFMATIAEGLTLAQVTGQSQQTLLDILN-----QGQLASIFLDQKCQNILQGNFKPDFYL  500

Query  231  PLLAKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMY  281
              + KD  +A+ L  A   P P+ A    + + A    + ++D SA  + Y
Sbjct  501  KYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAY  551


>Q922P9 Cytokine-like nuclear factor N-PAC [Mus musculus]
Length=546

 Score = 105 bits (261),  Expect = 1e-28
 Identities = 79/288 (27%), Positives = 129/288 (45%), Gaps = 19/288 (7%)

Query  3    QSVAFIGLGAMGYRMASHLPRHFDTVYVWNRSFEKAKQHATEYGTQAVELSQAVQADIIF  62
            + + F+GLG MG  + S+L +   TV VWNR+ EK        G    E+      DI F
Sbjct  267  KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEK---EGARLGRTPAEVVST--CDITF  321

Query  63   SCLPTSADVAQLVENLE-----LKPGTIWVDCTSGVPDLARQLVTQLKNQGVDYLDAPVS  117
            +C+        LV         ++PG  +VD ++   D   +L   + ++G  +L+APVS
Sbjct  322  ACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVS  381

Query  118  GQTIGADNATLTVMVGGDFTAFERAYPAMQAFGKLIKHVGESGAGFAVKAVNNMLLAVNL  177
            G    +++  L ++  GD   +E      QA GK    +GE G    +  + NM+    +
Sbjct  382  GNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFM  441

Query  178  WSVAEGFTTLKAHGVNLGEALDCINASSGKSGVTETIF----PQRVLNRSFPVTFALPLL  233
             ++AEG T  +  G +    LD +N      G   +IF     Q +L  +F   F L  +
Sbjct  442  ATIAEGLTLAQVTGQSQQTLLDILN-----QGQLASIFLDQKCQNILQGNFKPDFYLKYI  496

Query  234  AKDAGIALDLVHAAKLPAPLIALTQSLIQAANQTAEENSDFSAAVKMY  281
             KD  +A+ L  A   P P+ A    + + A    + ++D SA  + Y
Sbjct  497  QKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAY  544



Lambda      K        H        a         alpha
   0.320    0.133    0.387    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1176735


  Database: bc6a80d283e6b41ef7d8d28a8d5ee003.SwissProt.fasta
    Posted date:  May 18, 2024  7:25 PM
  Number of letters in database: 5,585
  Number of sequences in database:  17



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40