BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 5648c36e65d8dc324e0b38b89dec51b2.SwissProt.fasta
15 sequences; 5,416 total letters
Query= ACIAD2330
Length=371
Score E
Sequences producing significant alignments: (Bits) Value
P00888 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive... 397 1e-141
P0A1B6 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive... 396 3e-141
P0A1B5 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive... 396 3e-141
P0AB92 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive... 370 3e-131
P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive... 370 3e-131
P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhi... 354 2e-124
C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16 [Alterna... 348 6e-122
P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine... 343 5e-120
P79023 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhi... 342 7e-120
Q09755 Putative phospho-2-dehydro-3-deoxyheptonate aldolase [Schi... 341 2e-119
P44303 Phospho-2-dehydro-3-deoxyheptonate aldolase [Haemophilus i... 337 5e-118
Q9UT09 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhi... 336 3e-117
P35170 Phospho-2-dehydro-3-deoxyheptonate aldolase [Corynebacteri... 334 1e-116
P46245 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive... 333 2e-116
P00887 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive... 327 3e-114
>P00888 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
[Escherichia coli (strain K12)]
Length=356
Score = 397 bits (1021), Expect = 1e-141
Identities = 197/350 (56%), Positives = 250/350 (71%), Gaps = 1/350 (0%)
Query 21 IDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH 80
+++V+I Q L+TP +LKA PL+ + R++I +I+ G D R+ VV GPCSIH
Sbjct 6 LNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIH 65
Query 81 DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLR 140
DP+ A EYA R K L+ +V DSLY+VMRVYFEKPRTTVGWKGLINDP M+ SF++E GL+
Sbjct 66 DPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQ 125
Query 141 IGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVG 200
I RKLLLEL GLP ATEALDPNSPQY DL SWSAIGARTTESQTHREM+SGLS PVG
Sbjct 126 IARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVG 185
Query 201 FKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDA 260
FKNGTDG L A NAM++ H F+G+N+AGQV+++ T GNP HV+LRGG PNY
Sbjct 186 FKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKA-PNYSP 244
Query 261 GSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES 320
VA+ E + +A + +M+D SH NSNKD QP V ++V QI DGN+SI+G+M+ES
Sbjct 245 ADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIES 304
Query 321 HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR 370
++ G Q + +++YG SVTD CI WE T+ +L E+H+ L L R
Sbjct 305 NIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHQDLNGQLTAR 354
>P0A1B6 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
[Salmonella typhi]
Length=356
Score = 396 bits (1018), Expect = 3e-141
Identities = 196/350 (56%), Positives = 250/350 (71%), Gaps = 1/350 (0%)
Query 21 IDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH 80
+++V I Q L+TP +LKA PL+ + + R I +I+ G D R+ VV GPCSIH
Sbjct 6 LNNVRITDEQVLMTPEQLKAAFPLSLAQEAQIAQSRGIISDIIAGRDPRLLVVCGPCSIH 65
Query 81 DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLR 140
DP+ A EYA R K L+ +V DSLY+VMRVYFEKPRTTVGWKGLINDP M+ SF++E GL+
Sbjct 66 DPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLK 125
Query 141 IGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVG 200
I R+LL+EL GLP ATEALDPNSPQY DL SWSAIGARTTESQTHREM+SGLS PVG
Sbjct 126 IARQLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVG 185
Query 201 FKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDA 260
FKNGTDG L A NAM++ H F+G+N+AGQV+++ T GNP+ HV+LRGG PNY
Sbjct 186 FKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPHGHVILRGGKA-PNYSP 244
Query 261 GSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES 320
VA+ E + +A + +M+D SH NSNKD QP V ++V QI DGN+SI+G+M+ES
Sbjct 245 ADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIES 304
Query 321 HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR 370
++ G Q + +++YG SVTD CI WE T+ +L E+H+ L LA R
Sbjct 305 NIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHKDLSGQLAVR 354
>P0A1B5 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
[Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=356
Score = 396 bits (1018), Expect = 3e-141
Identities = 196/350 (56%), Positives = 250/350 (71%), Gaps = 1/350 (0%)
Query 21 IDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH 80
+++V I Q L+TP +LKA PL+ + + R I +I+ G D R+ VV GPCSIH
Sbjct 6 LNNVRITDEQVLMTPEQLKAAFPLSLAQEAQIAQSRGIISDIIAGRDPRLLVVCGPCSIH 65
Query 81 DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLR 140
DP+ A EYA R K L+ +V DSLY+VMRVYFEKPRTTVGWKGLINDP M+ SF++E GL+
Sbjct 66 DPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLK 125
Query 141 IGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVG 200
I R+LL+EL GLP ATEALDPNSPQY DL SWSAIGARTTESQTHREM+SGLS PVG
Sbjct 126 IARQLLVELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVG 185
Query 201 FKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDA 260
FKNGTDG L A NAM++ H F+G+N+AGQV+++ T GNP+ HV+LRGG PNY
Sbjct 186 FKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPHGHVILRGGKA-PNYSP 244
Query 261 GSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVES 320
VA+ E + +A + +M+D SH NSNKD QP V ++V QI DGN+SI+G+M+ES
Sbjct 245 ADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIES 304
Query 321 HLKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR 370
++ G Q + +++YG SVTD CI WE T+ +L E+H+ L LA R
Sbjct 305 NIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHKDLSGQLAVR 354
>P0AB92 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
[Escherichia coli O157:H7]
Length=350
Score = 370 bits (951), Expect = 3e-131
Identities = 193/343 (56%), Positives = 241/343 (70%), Gaps = 2/343 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
DD+ IK I+ L+ P L + P TE+A TV H R+ I IL G D R+ VVIGPCSIHD
Sbjct 6 DDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVIGPCSIHD 65
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
P AA EYATRL L E++KD L IVMRVYFEKPRTTVGWKGLINDP M++SF I GLRI
Sbjct 66 PVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQINDGLRI 125
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
RKLLL++N+ GLP A E LD +PQY DL+SW AIGARTTESQ HRE++SGLS PVGF
Sbjct 126 ARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASGLSCPVGF 185
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KNGTDG + VA +A+ + H FL + + G ++++TSGN H++LRGG +PNY A
Sbjct 186 KNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGK-EPNYSAK 244
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
VAE + L KA + ++MID SHANS+K Q V +V +QI G K+I+GVMVESH
Sbjct 245 HVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESH 304
Query 322 LKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALK 364
L G Q + E+ L YGKS+TD CI WE T+ +L ++ A+K
Sbjct 305 LVEGNQSL-ESGEPLAYGKSITDACIGWEDTDALLRQLANAVK 346
>P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
[Escherichia coli (strain K12)]
Length=350
Score = 370 bits (951), Expect = 3e-131
Identities = 193/343 (56%), Positives = 241/343 (70%), Gaps = 2/343 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
DD+ IK I+ L+ P L + P TE+A TV H R+ I IL G D R+ VVIGPCSIHD
Sbjct 6 DDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVIGPCSIHD 65
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
P AA EYATRL L E++KD L IVMRVYFEKPRTTVGWKGLINDP M++SF I GLRI
Sbjct 66 PVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQINDGLRI 125
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
RKLLL++N+ GLP A E LD +PQY DL+SW AIGARTTESQ HRE++SGLS PVGF
Sbjct 126 ARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASGLSCPVGF 185
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KNGTDG + VA +A+ + H FL + + G ++++TSGN H++LRGG +PNY A
Sbjct 186 KNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGK-EPNYSAK 244
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
VAE + L KA + ++MID SHANS+K Q V +V +QI G K+I+GVMVESH
Sbjct 245 HVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESH 304
Query 322 LKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALK 364
L G Q + E+ L YGKS+TD CI WE T+ +L ++ A+K
Sbjct 305 LVEGNQSL-ESGEPLAYGKSITDACIGWEDTDALLRQLANAVK 346
>P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
[Saccharomyces cerevisiae (strain ATCC 204508 / S288c)]
Length=370
Score = 354 bits (908), Expect = 2e-124
Identities = 184/350 (53%), Positives = 237/350 (68%), Gaps = 3/350 (1%)
Query 16 VSQPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIG 75
V+Q +DV I PL +PA L+ ++P T ++ +T GR +I+ G D R+ V++G
Sbjct 15 VNQGAEEDVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDRVLVIVG 74
Query 76 PCSIHDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNI 135
PCSIHD +AA EYA RLK LS+++K L I+MR Y EKPRTTVGWKGLINDPD+N++FNI
Sbjct 75 PCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPRTTVGWKGLINDPDVNNTFNI 134
Query 136 EKGLRIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGL 195
KGL+ R+L + L GLP +E LD SPQY DL+S+ AIGARTTESQ HRE++SGL
Sbjct 135 NKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYLADLVSFGAIGARTTESQLHRELASGL 194
Query 196 SSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGK 255
S PVGFKNGTDG L VA +A Q+ H H F+G+ + G ++ T GN + V+LRGG
Sbjct 195 SFPVGFKNGTDGTLNVAVDACQAAAHSHHFMGVTKHGVAAITTTKGNEHCFVILRGGKKG 254
Query 256 PNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVG 315
NYDA SVAEA+ L S +MID SH NSNKD QP V V EQI +G +I G
Sbjct 255 TNYDAKSVAEAKAQLPAG--SNGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITG 312
Query 316 VMVESHLKGGRQDIP-ENLCDLEYGKSVTDGCIDWETTENVLLEMHEALK 364
VM+ES++ G Q IP E L+YG S+TD CI WETTE+VL ++ A++
Sbjct 313 VMIESNINEGNQGIPAEGKAGLKYGVSITDACIGWETTEDVLRKLAAAVR 362
>C9K7C8 Phospho-2-dehydro-3-deoxyheptonate aldolase AMT16 [Alternaria
alternata]
Length=374
Score = 348 bits (892), Expect = 6e-122
Identities = 181/345 (52%), Positives = 229/345 (66%), Gaps = 3/345 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTD--KRIFVVIGPCSI 79
+D IK PL P L++E+P T + TV RE + I D KR+ VVIGPCSI
Sbjct 17 EDWRIKGYNPLTPPNLLQSEIPQTAKSRDTVFKAREEVIAIFQNKDAQKRLLVVIGPCSI 76
Query 80 HDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGL 139
HDP AA EY RL L EK +D L IVMR Y EKPRTT+GWKGLINDPD+++SF I KGL
Sbjct 77 HDPLAALEYCDRLMKLKEKYQDDLLIVMRSYLEKPRTTIGWKGLINDPDIDNSFKINKGL 136
Query 140 RIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPV 199
RI R+L +L E+G+P A+E LD SPQ+ D+ S IGARTTESQ HRE++SGLS PV
Sbjct 137 RISRQLFADLTEKGMPLASEMLDTISPQFLADMFSVGVIGARTTESQLHRELASGLSFPV 196
Query 200 GFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYD 259
GFKNGTDG L VA +A+ S K+ H FL + + G V+++ T GN ++LRGG NYD
Sbjct 197 GFKNGTDGTLDVAIDAIDSAKYPHHFLSVTKPGVVAIVGTIGNHDCFIILRGGRKGTNYD 256
Query 260 AGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVE 319
A S+ EA L ++ ++MID SH NS K+ QP V+ V EQI G +++GVM+E
Sbjct 257 AKSIKEAREKLESEGMNPRLMIDCSHGNSEKNHMNQPKVVHAVAEQIEAGETAVIGVMIE 316
Query 320 SHLKGGRQDIP-ENLCDLEYGKSVTDGCIDWETTENVLLEMHEAL 363
S+LK G Q +P E LEYG S+TD CIDW+TTE VL E+ A+
Sbjct 317 SNLKAGTQKVPKEGKAGLEYGMSITDACIDWKTTETVLAELAGAV 361
>P14843 Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited
[Saccharomyces cerevisiae (strain ATCC 204508
/ S288c)]
Length=370
Score = 343 bits (879), Expect = 5e-120
Identities = 176/351 (50%), Positives = 237/351 (68%), Gaps = 7/351 (2%)
Query 21 IDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIH 80
++D IK PL P L+ E P++ + ++ R+++ +IL+G D R+ +VIGPCS+H
Sbjct 14 LEDWRIKGYDPLTPPDLLQHEFPISAKGEENIIKARDSVCDILNGKDDRLVIVIGPCSLH 73
Query 81 DPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLR 140
DPKAA++YA RL +SEK+ L I+MR Y EKPRTTVGWKGLINDPDMN+SF I KGLR
Sbjct 74 DPKAAYDYADRLAKISEKLSKDLLIIMRAYLEKPRTTVGWKGLINDPDMNNSFQINKGLR 133
Query 141 IGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVG 200
I R++ ++L E+ LP A E LD SPQ+ D S AIGARTTESQ HRE++SGLS P+G
Sbjct 134 ISREMFIKLVEK-LPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIG 192
Query 201 FKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDA 260
FKNGTDGGL VA +AM++ H H FL + + G +++ T GN ++LRGG N+D
Sbjct 193 FKNGTDGGLQVAIDAMRAAAHEHYFLSVTKPGVTAIVGTEGNKDTFLILRGGKNGTNFDK 252
Query 261 GSVAEAENALAKAKVS----TKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGV 316
SV + L KA ++ +IMID SH NSNKD QP V K + +Q+ +G S+ GV
Sbjct 253 ESVQNTKKQLEKAGLTDDSQKRIMIDCSHGNSNKDFKNQPKVAKCIYDQLTEGENSLCGV 312
Query 317 MVESHLKGGRQDIPE--NLCDLEYGKSVTDGCIDWETTENVLLEMHEALKD 365
M+ES++ GRQDIP+ L+YG SVTD CI WE+TE VL + E +++
Sbjct 313 MIESNINEGRQDIPKEGGREGLKYGCSVTDACIGWESTEQVLELLAEGVRN 363
>P79023 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
[Candida albicans (strain SC5314 / ATCC MYA-2876)]
Length=370
Score = 342 bits (878), Expect = 7e-120
Identities = 175/350 (50%), Positives = 234/350 (67%), Gaps = 5/350 (1%)
Query 20 DIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSI 79
+ DD I PLV PA L+ E+ + + V+ GR IL G D R V++GPCSI
Sbjct 9 EYDDTRILGYDPLVPPALLQHEIKASAESLDVVIKGRYDSAQILKGNDDRCIVIVGPCSI 68
Query 80 HDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGL 139
HDP A EY RLK L++++KD L I+MR Y EKPRTTVGWKGLINDPD+++SF+I +GL
Sbjct 69 HDPPQALEYGKRLKKLADELKDDLVIIMRAYLEKPRTTVGWKGLINDPDVDNSFDINRGL 128
Query 140 RIGRKLLLELNE-QGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSP 198
+I R+L +L GLP +E LD SPQY+ D +S+ AIGARTTESQ HRE++SGLS P
Sbjct 129 KISRQLYSDLTSVVGLPIGSEMLDTISPQYFSDFLSFGAIGARTTESQLHRELASGLSFP 188
Query 199 VGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNY 258
+GFKNGTDGGL VA +A+Q+ GH F+G+ + G ++ T GN ++LRGG NY
Sbjct 189 IGFKNGTDGGLAVALDAVQASSKGHHFMGVTKNGMAAITTTKGNDCCFIILRGGKKITNY 248
Query 259 DAGSVAEAENALAK-AKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVM 317
D SV A+ A+AK S K+M+D SH NS KD QP VL +V EQI +G SI+GVM
Sbjct 249 DVESVKAAKEAIAKCTDPSIKLMVDCSHDNSRKDYRNQPQVLDSVAEQISNGEDSIIGVM 308
Query 318 VESHLKGGRQDIP---ENLCDLEYGKSVTDGCIDWETTENVLLEMHEALK 364
+ES++ G+Q +P L+YG S+TDGC+ WETT +L ++ +A++
Sbjct 309 IESNIHEGKQPMPPAGSGKEALKYGVSITDGCVSWETTVEMLTKLSQAVQ 358
>Q09755 Putative phospho-2-dehydro-3-deoxyheptonate aldolase [Schizosaccharomyces
pombe (strain 972 / ATCC 24843)]
Length=368
Score = 341 bits (875), Expect = 2e-119
Identities = 169/344 (49%), Positives = 232/344 (67%), Gaps = 1/344 (0%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
+D IK P+++PA +++EL ++ V R +I+ G D R+ +++GPCS+HD
Sbjct 20 EDSRIKGYDPVISPALIQSELAASDETLAFVSDQRRQAADIIAGRDDRLLLIVGPCSLHD 79
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
P AA EYA RL+ + K K L+I+MR Y EKPRTTVGWKGLINDPD++ S+NI KG+R+
Sbjct 80 PVAAKEYAIRLQKEAIKHKKDLHIIMRAYLEKPRTTVGWKGLINDPDLDGSYNINKGIRV 139
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
R++ LEL E G+ A+E LD SPQY DLI W AIGARTTESQ HRE++SGLS P+GF
Sbjct 140 ARRIFLELLETGVGIASEMLDTISPQYLADLICWGAIGARTTESQLHRELASGLSFPIGF 199
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KN TDG + +A +AM S + H FL + + G V+++ T+GNP H++LRGG N+DA
Sbjct 200 KNATDGNIGIAIDAMNSSANPHHFLSVTKQGVVAIVTTTGNPDTHIILRGGKSGTNFDAD 259
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
SVA A+ L + IMID SH NS+K+ QP V + EQ+ +G K+I GVM+ESH
Sbjct 260 SVAGAKAKLEECNKLPSIMIDCSHGNSSKNHKNQPKVAACIAEQVANGQKAITGVMIESH 319
Query 322 LKGGRQDIPE-NLCDLEYGKSVTDGCIDWETTENVLLEMHEALK 364
L G+Q IPE +L ++YG SVTD CI W+ T V ++ A++
Sbjct 320 LNEGKQAIPEDDLSSMKYGVSVTDACIGWDDTTAVFEQLAAAVR 363
>P44303 Phospho-2-dehydro-3-deoxyheptonate aldolase [Haemophilus
influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=362
Score = 337 bits (865), Expect = 5e-118
Identities = 176/349 (50%), Positives = 231/349 (66%), Gaps = 4/349 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
DD I+ + ++ P L + P +E A V R NI+ G D R+ VVIGPCSIHD
Sbjct 13 DDTRIEKVDQVLPPIALLEKYPASEQAAALVKQTRHEAHNIIHGKDDRLLVVIGPCSIHD 72
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
PKAA EYATRLK L EK KDSL I+MRVYFEKPRTTVGWKGLIN+P +ND++ + GLRI
Sbjct 73 PKAAIEYATRLKPLREKYKDSLEIIMRVYFEKPRTTVGWKGLINEPYLNDTYRLNDGLRI 132
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
RKLL ++N+ G+P A E LD +PQY D +SW AIGARTTESQ HRE++SGLS VGF
Sbjct 133 ARKLLSDINDLGVPAAGEFLDMITPQYLADFMSWGAIGARTTESQVHRELASGLSCAVGF 192
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KN T+GG+ VA +A+ + + H FL + + G +++ T GN H++LRGG+ PNY A
Sbjct 193 KNATNGGVKVALDAIGAAEAPHYFLSVTKFGHSAIVSTKGNEDCHIILRGGDKGPNYSAE 252
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
V + + K +M+D SHANS+K Q V ++V QI G+K I GVMVESH
Sbjct 253 DVEKVCADIEKTGRIPHVMVDFSHANSSKQYKKQMDVCQDVCNQIAFGSKQIFGVMVESH 312
Query 322 LKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEALKDVLAQR 370
L GRQD+ + YG+S+TD CI WE +E +L ++ +A V+A+R
Sbjct 313 LVEGRQDLVDGKAQ-TYGQSITDACIGWEDSERLLQQLSDA---VIARR 357
>Q9UT09 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
[Schizosaccharomyces pombe (strain 972 / ATCC 24843)]
Length=372
Score = 336 bits (861), Expect = 3e-117
Identities = 168/350 (48%), Positives = 240/350 (69%), Gaps = 3/350 (1%)
Query 18 QPDIDDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPC 77
Q +DD + PLV A ++ E+P++E++ + + R+ I+ IL+ D RI VV+GPC
Sbjct 14 QEHLDDNRVLGYNPLVPAALVQQEIPVSETSRKVITDSRKEIQAILNKQDDRIIVVVGPC 73
Query 78 SIHDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEK 137
SIHDPK A +YA LK +++++D+L +VMR Y EKPRTT+GWKGL+NDP+++ SF I K
Sbjct 74 SIHDPKLAMDYAKLLKPKADELQDALCVVMRCYLEKPRTTIGWKGLVNDPNLDGSFAINK 133
Query 138 GLRIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSS 197
G+R+ R++ ++ G+P A+E LD SPQ++ DL+S+ AIGARTTESQ HRE++S LS
Sbjct 134 GIRMARQMYCDVTNFGIPLASEMLDNISPQFFADLLSFGAIGARTTESQLHRELASALSF 193
Query 198 PVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPN 257
PVGFKNGTDG + VA +A+ + H H+ LG+ + G ++ T GN ++LRGG PN
Sbjct 194 PVGFKNGTDGTVGVAIDAIGATAHPHTMLGVTKQGLAAITMTRGNKDTFIILRGGKKGPN 253
Query 258 YDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVM 317
YDA VA L KA + +IMID SH NS+K+ QP V K++ EQI +G+ SIVGVM
Sbjct 254 YDAEHVAAVRKDLEKANLPPRIMIDCSHGNSSKNHLNQPKVSKSIAEQIRNGDSSIVGVM 313
Query 318 VESHLKGGRQDIP--ENLCD-LEYGKSVTDGCIDWETTENVLLEMHEALK 364
+ESH+ GRQD P + D L+YG S+TD C+ WE T +L ++ EA++
Sbjct 314 IESHINEGRQDAPIRPGVKDTLKYGVSITDACVSWEQTAPMLDDLAEAVR 363
>P35170 Phospho-2-dehydro-3-deoxyheptonate aldolase [Corynebacterium
glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384
/ JCM 1318 / LMG 3730 / NCIMB 10025)]
Length=366
Score = 334 bits (856), Expect = 1e-116
Identities = 172/362 (48%), Positives = 245/362 (68%), Gaps = 12/362 (3%)
Query 13 SNPVSQPDIDDVNIKSI---QPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKR 69
S+PVS + + K + L +P +L A PLT V R+ I +I G D R
Sbjct 2 SSPVSLENAASTSNKRVVAFHELPSPTDLIAANPLTPKQASKVEQDRQDIADIFAGDDDR 61
Query 70 IFVVIGPCSIHDPKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDM 129
+ VV+GPCS+HDP+AA +YA RL L++++ L IVMRVYFEKPRT VGWKGLINDP +
Sbjct 62 LVVVVGPCSVHDPEAAIDYANRLAPLAKRLDQDLKIVMRVYFEKPRTIVGWKGLINDPHL 121
Query 130 NDSFNIEKGLRIGRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHR 189
N++++I +GLRI RK+L+++ LP E L+PNSPQYY D ++W AIGARTTESQ HR
Sbjct 122 NETYDIPEGLRIARKVLIDVVNLDLPVGCEFLEPNSPQYYADTVAWGAIGARTTESQVHR 181
Query 190 EMSSGLSSPVGFKNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVL 249
+++SG+S P+GFKNGTDG + VA +A+Q+ ++ H F G ++ G +SV+ T+GN +H++L
Sbjct 182 QLASGMSMPIGFKNGTDGNIQVAVDAVQAAQNPHFFFGTSDDGALSVVETAGNSNSHIIL 241
Query 250 RGGNGKPNYDAGSVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDG 309
RGG PN+DA SV E + K + ++MIDASHANS KD Q V++ + EQI G
Sbjct 242 RGGTSGPNHDAASV---EAVVEKLGENARLMIDASHANSGKDHIRQVEVVREIAEQISGG 298
Query 310 NKSIVGVMVESHLKGGRQDI-PENLC-----DLEYGKSVTDGCIDWETTENVLLEMHEAL 363
++++ G+M+ES L GG Q++ P L L YG+SVTD CID +TT ++L E+ A+
Sbjct 299 SEAVAGIMIESFLVGGAQNLDPAKLRINGGEGLVYGQSVTDKCIDIDTTIDLLAELAAAV 358
Query 364 KD 365
++
Sbjct 359 RE 360
>P46245 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
[Buchnera aphidicola subsp. Schizaphis graminum (strain
Sg)]
Length=348
Score = 333 bits (854), Expect = 2e-116
Identities = 169/342 (49%), Positives = 230/342 (67%), Gaps = 2/342 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
D++ I PL+TP+EL + +T V+ R+ I I+ G D R+ VVIGPCS+HD
Sbjct 5 DELRTIRIDPLITPSELAKKYAITSEIMDNVIITRQNIARIMTGEDLRLLVVIGPCSVHD 64
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
P AA EYA RL L +K +D L I+MR YFEKPRT VGWKGLI+DPD+N SF + GL +
Sbjct 65 PIAAVEYAHRLYELRKKYQDRLEIIMRTYFEKPRTVVGWKGLISDPDLNGSFRVNHGLAV 124
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
RKLLL++NE G+P ATE LD Q+ DLISW AIGARTTESQ HREM+S LS PVGF
Sbjct 125 ARKLLLDINELGMPAATEFLDMVIGQFIADLISWGAIGARTTESQIHREMASALSCPVGF 184
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KNGTDG + +A +A+++ + H F N+ GQ+++ HTSGNPY H+++RGG PNY A
Sbjct 185 KNGTDGNIRIAIDAIRAAQARHLFFAPNKDGQMTINHTSGNPYGHIIMRGGR-TPNYHAH 243
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
+ A L + + +MID SH N K+ Q V K+V++QI G+K+I GVM+ES
Sbjct 244 DINSAIEHLREFNLLEHLMIDFSHGNCLKEHIRQKDVAKSVSKQISQGSKTIFGVMIESF 303
Query 322 LKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEAL 363
L+ G Q + EN L YGKS+TD C++W+ + ++ ++ +A+
Sbjct 304 LEEGFQTVKENQ-PLIYGKSITDACLNWKDSVLIIKQLADAV 344
>P00887 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
[Escherichia coli (strain K12)]
Length=348
Score = 327 bits (839), Expect = 3e-114
Identities = 167/342 (49%), Positives = 227/342 (66%), Gaps = 2/342 (1%)
Query 22 DDVNIKSIQPLVTPAELKAELPLTESAYQTVLHGRETIRNILDGTDKRIFVVIGPCSIHD 81
D++ I+ LVTPAEL P+T V R I IL+G DKR+ V+IGPCSIHD
Sbjct 5 DELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKRLLVIIGPCSIHD 64
Query 82 PKAAHEYATRLKVLSEKVKDSLYIVMRVYFEKPRTTVGWKGLINDPDMNDSFNIEKGLRI 141
AA EYATRL+ L + + L IVMR YFEKPRT VGWKGLI+DPD+N S+ + GL +
Sbjct 65 LTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRVNHGLEL 124
Query 142 GRKLLLELNEQGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGF 201
RKLLL++NE G+P ATE LD + Q+ DLISW AIGARTTESQ HREM+S LS PVGF
Sbjct 125 ARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSCPVGF 184
Query 202 KNGTDGGLTVATNAMQSVKHGHSFLGLNEAGQVSVIHTSGNPYAHVVLRGGNGKPNYDAG 261
KNGTDG +A +A+++ + H FL ++ GQ+++ TSGNPY H+++RGG KPNY A
Sbjct 185 KNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGK-KPNYHAD 243
Query 262 SVAEAENALAKAKVSTKIMIDASHANSNKDPYLQPLVLKNVTEQIIDGNKSIVGVMVESH 321
+A A + L + + +++D SH N K Q V +++ +QI +G+ +I G+M ES
Sbjct 244 DIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTAIAGIMAESF 303
Query 322 LKGGRQDIPENLCDLEYGKSVTDGCIDWETTENVLLEMHEAL 363
L+ G Q I + L YG+S+TD C+ WE TE ++ ++ A+
Sbjct 304 LREGTQKIVGSQ-PLTYGQSITDPCLGWEDTERLVEKLASAV 344
Lambda K H a alpha
0.315 0.132 0.382 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1516808
Database: 5648c36e65d8dc324e0b38b89dec51b2.SwissProt.fasta
Posted date: May 9, 2024 3:29 AM
Number of letters in database: 5,416
Number of sequences in database: 15
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
