Comparative Genomics

ACIAD2408 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 4f32a1f67f0a3a586bf0b4e7abc515bd.SwissProt.fasta
           18 sequences; 2,960 total letters



Query= ACIAD2408

Length=127
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P0A3E2 Dihydroneopterin aldolase [Streptococcus pyogenes serotype...  79.0    1e-23
P0C0G5 Dihydroneopterin aldolase [Streptococcus pyogenes serotype...  79.0    1e-23
P0DB13 Dihydroneopterin aldolase [Streptococcus pyogenes serotype...  77.4    4e-23
P0DB12 Dihydroneopterin aldolase [Streptococcus pyogenes serotype...  77.4    4e-23
Q5XCA7 Dihydroneopterin aldolase [Streptococcus pyogenes serotype...  76.3    1e-22
P0AC18 Dihydroneopterin aldolase [Shigella flexneri]                  74.3    7e-22
P0AC17 Dihydroneopterin aldolase [Escherichia coli O6:H1 (strain ...  74.3    7e-22
P0AC16 Dihydroneopterin aldolase [Escherichia coli (strain K12)]      74.3    7e-22
P0C0G4 Dihydroneopterin aldolase [Streptococcus pyogenes]             73.6    1e-21
P46362 Dihydroneopterin aldolase [Haemophilus influenzae (strain ...  67.4    3e-19
P28823 Dihydroneopterin aldolase [Bacillus subtilis (strain 168)]     59.7    3e-16
Q9SF23 Dihydroneopterin aldolase 1 [Arabidopsis thaliana]             59.7    6e-16
P74342 Probable dihydroneopterin aldolase [Synechocystis sp. (str...  52.8    2e-13
Q9FM54 Dihydroneopterin aldolase 2 [Arabidopsis thaliana]             51.6    5e-13
Q6GKX5 Probable dihydroneopterin aldolase 3 [Arabidopsis thaliana]    49.7    5e-12
P9WNC5 Dihydroneopterin aldolase [Mycobacterium tuberculosis (str...  48.5    8e-12
P71513 Dihydroneopterin aldolase [Methylorubrum extorquens (strai...  47.0    3e-11
P53848 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropte...  45.8    3e-10


>P0A3E2 Dihydroneopterin aldolase [Streptococcus pyogenes serotype 
M18 (strain MGAS8232)]
Length=119

 Score = 79.0 bits (193),  Expect = 1e-23
 Identities = 47/119 (39%), Positives = 68/119 (57%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+EG +     G F  E+ + Q  L+DL +  DLQ A+ SD+L DT++Y  + +  
Sbjct  1    MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGMVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LIE  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGEKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>P0C0G5 Dihydroneopterin aldolase [Streptococcus pyogenes serotype 
M1]
Length=119

 Score = 79.0 bits (193),  Expect = 1e-23
 Identities = 47/119 (39%), Positives = 68/119 (57%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+EG +     G F  E+ + Q  L+DL +  DLQ A+ SD+L DT++Y  + +  
Sbjct  1    MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGMVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LIE  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGEKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>P0DB13 Dihydroneopterin aldolase [Streptococcus pyogenes serotype 
M3 (strain SSI-1)]
Length=119

 Score = 77.4 bits (189),  Expect = 4e-23
 Identities = 47/119 (39%), Positives = 68/119 (57%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+EG +     G F  E+ + Q  L+DL +  DLQ A+ SD+L DT++Y  + +  
Sbjct  1    MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGIVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LIE  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGGKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>P0DB12 Dihydroneopterin aldolase [Streptococcus pyogenes serotype 
M3 (strain ATCC BAA-595 / MGAS315)]
Length=119

 Score = 77.4 bits (189),  Expect = 4e-23
 Identities = 47/119 (39%), Positives = 68/119 (57%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+EG +     G F  E+ + Q  L+DL +  DLQ A+ SD+L DT++Y  + +  
Sbjct  1    MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGIVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LIE  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGGKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>Q5XCA7 Dihydroneopterin aldolase [Streptococcus pyogenes serotype 
M6 (strain ATCC BAA-946 / MGAS10394)]
Length=119

 Score = 76.3 bits (186),  Expect = 1e-22
 Identities = 46/119 (39%), Positives = 67/119 (56%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+E  +     G F  E+ + Q  L+DL +  DLQ A+ SD+L DT++Y  + +  
Sbjct  1    MDKIVLESCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGMVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LIE  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGGKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>P0AC18 Dihydroneopterin aldolase [Shigella flexneri]
Length=122

 Score = 74.3 bits (181),  Expect = 7e-22
 Identities = 41/115 (36%), Positives = 66/115 (57%), Gaps = 1/115 (1%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD + IE L V T +G ++WE+ I Q L+ D+ +  D +KAA SD++ D L+YA I E  
Sbjct  1    MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLER  115
               ++  +  L+E  A  V ++L   F +   + I + KP  +A A +VG+ +ER
Sbjct  61   VSHVEGARFALVERVAEEVAELLLARFNS-PWVRIKLSKPGAVARAANVGVIIER  114


>P0AC17 Dihydroneopterin aldolase [Escherichia coli O6:H1 (strain 
CFT073 / ATCC 700928 / UPEC)]
Length=122

 Score = 74.3 bits (181),  Expect = 7e-22
 Identities = 41/115 (36%), Positives = 66/115 (57%), Gaps = 1/115 (1%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD + IE L V T +G ++WE+ I Q L+ D+ +  D +KAA SD++ D L+YA I E  
Sbjct  1    MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLER  115
               ++  +  L+E  A  V ++L   F +   + I + KP  +A A +VG+ +ER
Sbjct  61   VSHVEGARFALVERVAEEVAELLLARFNS-PWVRIKLSKPGAVARAANVGVIIER  114


>P0AC16 Dihydroneopterin aldolase [Escherichia coli (strain K12)]
Length=122

 Score = 74.3 bits (181),  Expect = 7e-22
 Identities = 41/115 (36%), Positives = 66/115 (57%), Gaps = 1/115 (1%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD + IE L V T +G ++WE+ I Q L+ D+ +  D +KAA SD++ D L+YA I E  
Sbjct  1    MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLER  115
               ++  +  L+E  A  V ++L   F +   + I + KP  +A A +VG+ +ER
Sbjct  61   VSHVEGARFALVERVAEEVAELLLARFNS-PWVRIKLSKPGAVARAANVGVIIER  114


>P0C0G4 Dihydroneopterin aldolase [Streptococcus pyogenes]
Length=119

 Score = 73.6 bits (179),  Expect = 1e-21
 Identities = 44/119 (37%), Positives = 67/119 (56%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD IV+EG +     G +  E+ + Q  L+DL +  DLQ A+ S +L DT++Y  + +  
Sbjct  1    MDKIVLEGCRFYGYHGAYKEEQTLGQIFLVDLELSVDLQAASLSSQLTDTVHYGMVFDSV  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRK--PAIIAEAHSVGIRLERQR  117
             Q ++  +  LI+  A  + + LF  FP IE+I + I+K  P I     +VGI LERQR
Sbjct  61   RQLVEGEKFILIDGLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR  119


>P46362 Dihydroneopterin aldolase [Haemophilus influenzae (strain 
ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=118

 Score = 67.4 bits (163),  Expect = 3e-19
 Identities = 38/115 (33%), Positives = 68/115 (59%), Gaps = 1/115 (1%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD + IE L V   +G ++WE+QI Q L+ DL +  D ++AA +D++   LNYA++ +  
Sbjct  1    MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAI  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLER  115
               +++    LIE  A+ V  +L E+   ++ + I + KP  +A+A +VG+ + R
Sbjct  61   IDYVESKPFLLIERVAYEVADLL-ESRYQLQGLKIKLSKPKAVAQARNVGVLIVR  114


>P28823 Dihydroneopterin aldolase [Bacillus subtilis (strain 168)]
Length=120

 Score = 59.7 bits (143),  Expect = 3e-16
 Identities = 34/119 (29%), Positives = 59/119 (50%), Gaps = 2/119 (2%)

Query  1    MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
            MD + +EG++     G F  E ++ Q   +DLT   DL KA  +D+LE T+NYA++  + 
Sbjct  1    MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQTDDLEQTINYAELYHVC  60

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAH--SVGIRLERQR  117
               ++    KL+E  A  +   +   F  ++   + + KP      H  SV I + R++
Sbjct  61   KDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDPPIPGHYKSVAIEITRKK  119


>Q9SF23 Dihydroneopterin aldolase 1 [Arabidopsis thaliana]
Length=146

 Score = 59.7 bits (143),  Expect = 6e-16
 Identities = 36/120 (30%), Positives = 61/120 (51%), Gaps = 3/120 (3%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
            D ++++GLK     G    ER + Q  L+D+     L+KA  SD LEDT++Y  I  LA 
Sbjct  22   DKLILKGLKFYGFHGAIAEERTLGQMFLVDIDAWVSLKKAGESDNLEDTISYVDIFSLAK  81

Query  62   QSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSV---GIRLERQRH  118
            + ++     L+E  A L+     E F  I ++ + + KP +     ++   G+ + RQR+
Sbjct  82   EIVEGSPRNLLETVAELIASKTLEKFHQINAVRVKLSKPNVALIKSTIDYLGVDIFRQRN  141


>P74342 Probable dihydroneopterin aldolase [Synechocystis sp. 
(strain PCC 6803 / Kazusa)]
Length=118

 Score = 52.8 bits (125),  Expect = 2e-13
 Identities = 31/89 (35%), Positives = 48/89 (54%), Gaps = 0/89 (0%)

Query  1   MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA  60
           MD + ++G++     G F+ E+ + Q   +DLTI  DL KA  SD+L DTLNYA    + 
Sbjct  1   MDTLNVKGIRAYGYTGYFDAEQFLGQWFEVDLTIWIDLAKAGQSDDLNDTLNYADAVAIV  60

Query  61  AQSIQTVQPKLIEHAAHLVLKILFETFPT  89
            + I+  + K+IE  A  +   +  T  T
Sbjct  61  QKLIRESKFKMIEKLAEAIADAILGTGKT  89


>Q9FM54 Dihydroneopterin aldolase 2 [Arabidopsis thaliana]
Length=131

 Score = 51.6 bits (122),  Expect = 5e-13
 Identities = 31/119 (26%), Positives = 57/119 (48%), Gaps = 3/119 (3%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
            D +++ GLK     G    E+ + Q  +LD+     L+KA  SD L D+++Y  I  +A 
Sbjct  10   DKLILRGLKFYGFHGAIPEEKTLGQMFMLDIDAWMCLKKAGLSDNLADSVSYVDIYNVAK  69

Query  62   QSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSV---GIRLERQR  117
            + ++     L+E  A L+     E  P I ++ + + KP +     ++   G+ + R R
Sbjct  70   EVVEGSSRNLLERVAGLIASKTLEISPRITAVRVKLWKPNVALIQSTIDYLGVEIFRDR  128


>Q6GKX5 Probable dihydroneopterin aldolase 3 [Arabidopsis thaliana]
Length=160

 Score = 49.7 bits (117),  Expect = 5e-12
 Identities = 33/121 (27%), Positives = 58/121 (48%), Gaps = 3/121 (2%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
            D +++ GLK     G    ER++    ++D+ +   L+KA  SD L DT+++A    L  
Sbjct  40   DKLILRGLKFYGFHGVLPEERELGGLFIVDINLWLSLKKAIESDNLADTVSFADTFRLVK  99

Query  62   QSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKP---AIIAEAHSVGIRLERQRH  118
            + ++     L E  A  +   + ETFP I  I +   KP    + +    +G  L R+R+
Sbjct  100  KIVEGPPRNLYETVADDIASEMLETFPKINVIRVKFGKPNPSLVNSTVDFLGAELFRKRN  159

Query  119  N  119
            +
Sbjct  160  H  160


>P9WNC5 Dihydroneopterin aldolase [Mycobacterium tuberculosis 
(strain ATCC 25618 / H37Rv)]
Length=133

 Score = 48.5 bits (114),  Expect = 8e-12
 Identities = 29/99 (29%), Positives = 52/99 (53%), Gaps = 1/99 (1%)

Query  2   DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
           D I + GL V+   G ++ ER   Q  ++D+T+  DL +AA SD+L DT +Y ++   AA
Sbjct  3   DRIELRGLTVHGRHGVYDHERVAGQRFVIDVTVWIDLAEAANSDDLADTYDYVRLASRAA  62

Query  62  QSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKP  100
           + +     KLIE     +   + +    + ++ + + KP
Sbjct  63  EIVAGPPRKLIETVGAEIADHVMDD-QRVHAVEVAVHKP  100


>P71513 Dihydroneopterin aldolase [Methylorubrum extorquens (strain 
ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)]
Length=130

 Score = 47.0 bits (110),  Expect = 3e-11
 Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 0/100 (0%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
            D I++  L V    G    E ++ Q   + L    DL  A  SD++  T++YA + E+A 
Sbjct  3    DRILVHRLAVFARHGVLPEEERLGQRFYISLECRLDLAPAGRSDDVAATVSYADLAEIAL  62

Query  62   QSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPA  101
                  +  LIE  A  + +     FP IE+I + I KP+
Sbjct  63   DIATNRRFALIEALAEAIAETCLARFPRIETIAVRIDKPS  102


>P53848 Dihydroneopterin aldolase / 6-hydroxymethyl-7,8-dihydropterin 
pyrophosphokinase / Dihydropteroate synthase [Saccharomyces 
cerevisiae (strain ATCC 204508 / S288c)]
Length=824

 Score = 45.8 bits (107),  Expect = 3e-10
 Identities = 28/126 (22%), Positives = 64/126 (51%), Gaps = 1/126 (1%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAA  61
            D + I+ L++NTV+G  +W + + Q  LL L +  D  K+A +D+L+ +LNYA I     
Sbjct  22   DYVHIKKLEMNTVLGPDSWNQLMPQKCLLSLDMGTDFSKSAATDDLKYSLNYAVISRDLT  81

Query  62   QSIQTVQP-KLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNF  120
              +   +    + + A  V + + + +  +E + + ++       +  +   ++++R N 
Sbjct  82   NFVSKKKNWGSVSNLAKSVSQFVMDKYSGVECLNLEVQADTTHIRSDHISCIIQQERGNP  141

Query  121  CTRTFE  126
             ++ F+
Sbjct  142  ESQEFD  147


 Score = 28.5 bits (62),  Expect = 3e-04
 Identities = 27/116 (23%), Positives = 53/116 (46%), Gaps = 5/116 (4%)

Query  2    DAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTL-NYAQICELA  60
            D + I  LK+ T++G F +ER   Q + LD+ +    +KA     ++  + N  +  E  
Sbjct  147  DVVRISELKMLTLIGVFTFERLKKQYVTLDIKLPWP-KKAELPPPVQSIIDNVVKFVE--  203

Query  61   AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQ  116
              + +TV+  +   +A +     F+ FP    +++ + K   I     VG+   R+
Sbjct  204  ESNFKTVEALVESVSAVIAHNEYFQKFPD-SPLVVKVLKLNAITATEGVGVSCIRE  258



Lambda      K        H        a         alpha
   0.329    0.140    0.416    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 218364


  Database: 4f32a1f67f0a3a586bf0b4e7abc515bd.SwissProt.fasta
    Posted date:  May 29, 2024  9:08 PM
  Number of letters in database: 2,960
  Number of sequences in database:  18



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40