BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 3b903f0d7894967b7699045fbf4adaf6.SwissProt.fasta
12 sequences; 16,209 total letters
Query= ACIAD2468
Length=499
Score E
Sequences producing significant alignments: (Bits) Value
Q12553 Xanthine dehydrogenase [Emericella nidulans (strain FGSC A... 240 4e-72
P10351 Xanthine dehydrogenase [Drosophila melanogaster] 206 3e-60
Q54FB7 Xanthine dehydrogenase [Dictyostelium discoideum] 199 5e-58
P91711 Xanthine dehydrogenase [Drosophila subobscura] 197 2e-57
P80457 Xanthine dehydrogenase / Xanthine oxidase [Bos taurus] 197 3e-57
P22985 Xanthine dehydrogenase / Xanthine oxidase [Rattus norvegicus] 196 5e-57
P47989 Xanthine dehydrogenase / Xanthine oxidase [Homo sapiens] 195 1e-56
P22811 Xanthine dehydrogenase [Drosophila pseudoobscura pseudoobs... 194 2e-56
Q00519 Xanthine dehydrogenase / Xanthine oxidase [Mus musculus] 191 4e-55
Q6AUV1 Xanthine dehydrogenase [Oryza sativa subsp. japonica] 164 4e-46
Q8GUQ8 Xanthine dehydrogenase 1 [Arabidopsis thaliana] 162 2e-45
R4ZGN4 Xanthine dehydrogenase [Blastobotrys adeninivorans] 144 1e-39
>Q12553 Xanthine dehydrogenase [Emericella nidulans (strain FGSC
A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)]
Length=1363
Score = 240 bits (613), Expect = 4e-72
Identities = 175/558 (31%), Positives = 262/558 (47%), Gaps = 80/558 (14%)
Query 6 VTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGEL-- 63
+ F+ G + V P +T+L++LR G TGTK GCAEG CGACTVV+ ++
Sbjct 37 IRFYLNGTKVILDSVDPEITLLEYLRGIG------LTGTKLGCAEGGCGACTVVVSQINP 90
Query 64 VNDQLQLRSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFC 123
+L S+NACI L +DGK + TVE + + H +QQ + +GSQCGFC
Sbjct 91 TTKKLYHASINACIAPLVAVDGKHVITVEGIGNVKNP-----HAIQQRLAIGNGSQCGFC 145
Query 124 TPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQ-----------KAF 172
TPG +MSL+++ N+ P + V + GNLCRCTGYRPILDAAQ +A
Sbjct 146 TPGIVMSLYALLRNDP-KPSEHAVEEAFDGNLCRCTGYRPILDAAQSFTSPIGCGKARAN 204
Query 173 DYPKVMLERQ------------NIIEALKQIQALPSLQLEY------------------- 201
+E Q E +K A P +EY
Sbjct 205 GGSGCCMEEQKGTNGCCKGSSEETTEDVKHKFASPDF-IEYKPDTELIFPPSLWKHELRP 263
Query 202 -----QGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQE 256
+ ++++ P TVQ+ ++ +P A+++ GST+ + + G +Y+G + E
Sbjct 264 LAFGNKRKKWYRPVTVQQLLEIKSIHPDAKLIGGSTETQIEIKFKQMRYGASVYLGDLAE 323
Query 257 LKSIDIDQNMLHIGANVSLSDALSKISD------------IYPDFEELQRRFASMPIKNA 304
L+ N L IGAN+SL+D L + D + ++ R FA I+N
Sbjct 324 LRQFAFHDNYLEIGANISLTD-LESVCDQAIERYGSARGQPFAAIKKQLRYFAGRQIRNV 382
Query 305 GTLGGNIANGSPIGDSMPALITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGEFVEA 364
+ GN+A SPI D P + +T L RS ++ +I + ++ Y+ TAL + +
Sbjct 383 ASPAGNLATASPISDLNPVFVATNTTLVARSLDKETEIPMTQFFRGYRSTALPPDAIISS 442
Query 365 ILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKVVQSINIAFGGMAAIPKRA 424
+ IP S K YK SKR + DI+ V AA L + V S+++ FGGMA + A
Sbjct 443 LRIPTASEKGEYLRAYKQSKRKDDDIAIVNAALRVSLSSSNDVTSVSLVFGGMAPLTVSA 502
Query 425 VQAEAVLLGKVMS-AELIQHAQVALAQDFQ-PLSDGRASSAYRLQVAQNCLQRFY---LE 479
AEA L GK + ++ AL QDF + YR +A RFY L
Sbjct 503 RNAEAFLTGKKFTDPATLEGTMGALEQDFNLKFGVPGGMATYRKSLALGFFYRFYHDVLS 562
Query 480 KIEDTPMTRVDDLIALVE 497
+IE + ++A +E
Sbjct 563 QIEARSSDLDNSVVAEIE 580
>P10351 Xanthine dehydrogenase [Drosophila melanogaster]
Length=1335
Score = 206 bits (523), Expect = 3e-60
Identities = 167/555 (30%), Positives = 269/555 (48%), Gaps = 78/555 (14%)
Query 1 MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI 60
MS + FF GK P T+L FLRE ++R GTK GCAEG CGACTV++
Sbjct 1 MSNSVLVFFVNGKKVTEVSPDPECTLLTFLRE-----KLRLCGTKLGCAEGGCGACTVMV 55
Query 61 GELVNDQLQLR--SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGS 118
L ++R +VNAC+ + ++ G A+ TVE + S+++ LHPVQ+ + + HGS
Sbjct 56 SRLDRRANKIRHLAVNACLTPVCSMHGCAVTTVEGIG----STKTRLHPVQERLAKAHGS 111
Query 119 QCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQ---KAF--- 172
QCGFCTPG +MS++++ N + P + GNLCRCTGYRPIL+ + K F
Sbjct 112 QCGFCTPGIVMSMYALLRN-AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACG 170
Query 173 -----------------DYPKVMLERQNI--IEALKQIQALPSLQLE--YQGQQ------ 205
+ + ER ++ ++ P LQL + Q
Sbjct 171 MGEKCCKVSGKGCGTDAETDDKLFERSEFQPLDPSQEPIFPPELQLSDAFDSQSLIFSSD 230
Query 206 ---FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSIDI 262
++ P ++E L+ ++P A++V G+T+VG+ V ++ QV+EL I
Sbjct 231 RVTWYRPTNLEELLQLKAKHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKE 290
Query 263 DQNMLHIGANVSLSDALSKISDIYPDFEELQRR-----------FASMPIKNAGTLGGNI 311
+Q+ ++ GA VSL + + + E + R FA I+N LGGNI
Sbjct 291 NQDGIYFGAAVSLMEIDALLRQRIEQLPESETRLFQCTVDMLHYFAGKQIRNVACLGGNI 350
Query 312 ANGSPIGDSMPALITLDTILRLRS---GE-QRRDIAL-ADYYLDYQKTALQAGEFVEAIL 366
GSPI D P L L + S G+ Q+R + + ++ Y++ ++A E +L
Sbjct 351 MTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSVHMGTGFFTGYRRNVIEAHE----VL 406
Query 367 IPIHSSKTFK---FATYKISKRFEQDISAVCAAFSCELDE-NKVVQSINIAFGGMAAIPK 422
+ IH KT +K ++R + DI+ V AA + +E + +V I++AFGGMA
Sbjct 407 LGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNIVAEISMAFGGMAPTTV 466
Query 423 RAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASS--AYRLQVAQNCLQRFYLE- 479
A + +++G+ S +L++ +L + PL+ AYR + + + YL
Sbjct 467 LAPRTSQLMVGQEWSHQLVERVAESLCTEL-PLAASAPGGMIAYRRALVVSLFFKAYLAI 525
Query 480 --KIEDTPMTRVDDL 492
K+ + +T D L
Sbjct 526 SLKLSKSGITSSDAL 540
>Q54FB7 Xanthine dehydrogenase [Dictyostelium discoideum]
Length=1358
Score = 199 bits (506), Expect = 5e-58
Identities = 150/561 (27%), Positives = 253/561 (45%), Gaps = 98/561 (17%)
Query 3 QRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGE 62
+ + FF G+ + P ++ L ++R G TG K GC+EG CG+CT ++
Sbjct 17 ENQLLFFLNGEKVLINEPNPELSTLDYIRSIG------LTGLKRGCSEGACGSCTFMLSN 70
Query 63 LVND-----QLQLRSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHG 117
+V D ++ R+VN C+ L LDG A+ T+E L + + LH +Q+ + E+ G
Sbjct 71 VVKDDNDTFRIVHRAVNGCLYPLCALDGMAVTTIEGLGNI----DKGLHSIQERISENSG 126
Query 118 SQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQKAFDYP-- 175
SQCGFCTPG IM+L++ + ++ K + GNLCRCTGYRPILDAA+ + P
Sbjct 127 SQCGFCTPGIIMALYAFLRSNPNSTQK-DIEQNFDGNLCRCTGYRPILDAAKSFANQPSD 185
Query 176 ----KVMLERQNIIE-------------------------------ALKQIQALPSLQLE 200
++ L I+ L P +E
Sbjct 186 EQLVELPLPPMATIDDKKDDTQMICPGTGKPCNCKTKTSHIPNKPMELNSEPIFPPFLME 245
Query 201 YQGQQ---------FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYI 251
Y+ + ++ P T++E ++++ A+IV G+T++G+ ++
Sbjct 246 YKKESLKFTGSRVTWYTPTTLEELLKIKKEKTNAKIVVGNTEIGIETRFRSIVYPTIICP 305
Query 252 GQVQELKSIDIDQNMLHIGANVSLSDALSKISDIYPDFEELQ----------------RR 295
+V+EL I + N + +GA+V+L++ S ++ I E + +
Sbjct 306 TRVEELIQIQKEDNGVRVGASVTLTEMKSYLNGIIKSSENDEIANKKNGTFKAIISQLKW 365
Query 296 FASMPIKNAGTLGGNIANGSPIGDSMPALITLDTILRLRS-----GEQRRDIALADYYLD 350
FA ++NA ++GGN+ SPI D P L+ +L + S + RR + + ++L
Sbjct 366 FAGNQVRNAASIGGNLCTASPISDLNPVLLAAGAVLTMVSLDDNGAKVRRQVPINQFFLR 425
Query 351 YQKTALQAGEFVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAF-----------SC 399
Y+ ++ E +E++ IP F YK S+R E DI+ V F S
Sbjct 426 YRVVDIKPEEILESVFIPYTRPLEF-IQAYKQSRRREDDIAIVSCCFRVLLEPIAESASN 484
Query 400 ELDENKVVQSINIAFGGMAAIPKRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGR 459
+D N ++ +A+GGM + E L+G V S EL+ A + L D PL+ G
Sbjct 485 TVDSNFKIKDCVLAYGGMNVKAVTCEKTEKQLIGSVWSRELLNDACLNLESDL-PLAAGA 543
Query 460 ASS--AYRLQVAQNCLQRFYL 478
YR + +++L
Sbjct 544 PGGMIEYRRSLTTGFFFKYFL 564
>P91711 Xanthine dehydrogenase [Drosophila subobscura]
Length=1344
Score = 197 bits (501), Expect = 2e-57
Identities = 160/537 (30%), Positives = 254/537 (47%), Gaps = 79/537 (15%)
Query 6 VTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVN 65
+ FF GK P T+L +LR D++R GTK GCAEG CGACTV+I +
Sbjct 11 LVFFVNGKKVTDTNPDPECTLLTYLR-----DKLRLCGTKLGCAEGGCGACTVMISRMDR 65
Query 66 DQLQLR--SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFC 123
Q ++R +VNAC+ + + G A+ TVE + S+ + LHPVQ+ + + HGSQCGFC
Sbjct 66 GQHKIRHLAVNACLTPVCAMHGCAVTTVEGIG----STRTRLHPVQERLAKAHGSQCGFC 121
Query 124 TPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQ---KAF-------- 172
TPG +MS++++ N + P + GNLCRCTGYRPIL+ + K F
Sbjct 122 TPGIVMSMYALLRN-AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFLCGMGEKC 180
Query 173 -----------DYPK-----VMLERQNI--IEALKQIQALPSLQLE--YQGQQ------- 205
D P+ + ER ++A ++ P LQL Y +
Sbjct 181 CRVNGKGCGGGDDPESVTDDTLFERSKFQPLDASQEPIFPPELQLSNAYDSESLVFSSER 240
Query 206 --FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSIDID 263
++ P T+QE L+ +P A++V G+T+VG+ V ++ V EL+ +
Sbjct 241 VTWYRPTTLQELLQLKAAHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTLVAELQEVRES 300
Query 264 QNMLHIGANVSLSDALSKISDIYPDFEELQRR-----------FASMPIKNAGTLGGNIA 312
+ ++ GA VSL + + + + E Q R FA I+N LGGNI
Sbjct 301 EESIYFGAAVSLMEIDALLRQRIEELPEAQTRLFQCTVDMLHYFAGKQIRNVACLGGNIM 360
Query 313 NGSPIGDSMPALITLDTILRLRS-----GEQRRDIALADYYLDYQKTALQAGEFVEAILI 367
GSPI D P L L + S QR ++ Y++ ++ E +L+
Sbjct 361 TGSPISDMNPVLTAAGARLEVASIVEGKISQRTVHMGTGFFTGYRRNVIEPQE----VLL 416
Query 368 PIHSSKTF---KFATYKISKRFEQDISAVCAAFSCELD-ENKVVQSINIAFGGMAAIPKR 423
IH KT +K ++R + DI+ V AA + + ++ VV I++AFGGMA
Sbjct 417 GIHFQKTTPDQHVVAFKQARRRDDDIAIVNAAVNVRFEPKSNVVAEISMAFGGMAPTTVL 476
Query 424 AVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASS--AYRLQVAQNCLQRFYL 478
A + +++ + + +L++ +L + PL+ AYR + + + + YL
Sbjct 477 APRTSQLMVKQPLDHQLLERVAESLCGEL-PLAASAPGGMIAYRRALVVSLIFKAYL 532
>P80457 Xanthine dehydrogenase / Xanthine oxidase [Bos taurus]
Length=1332
Score = 197 bits (500), Expect = 3e-57
Identities = 149/532 (28%), Positives = 251/532 (47%), Gaps = 65/532 (12%)
Query 1 MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI 60
M+ + FF GK P T+L +LR GL GTK GC EG CGACTV++
Sbjct 1 MTADELVFFVNGKKVVEKNADPETTLLAYLRRKLGL-----RGTKLGCGEGGCGACTVML 55
Query 61 GEL--VNDQLQLRSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGS 118
+ + D++ S NAC+ + TL A+ TVE + S+++ LHPVQ+ + + HGS
Sbjct 56 SKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIG----STKTRLHPVQERIAKSHGS 111
Query 119 QCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDA----------- 167
QCGFCTPG +MS++++ N+ P ++ D GNLCRCTGYRPIL
Sbjct 112 QCGFCTPGIVMSMYTLLRNQPE-PTVEEIEDAFQGNLCRCTGYRPILQGFRTFAKNGGCC 170
Query 168 ---------------------AQKAFDYPKVM----LERQNIIEALKQIQALPSLQLEYQ 202
+ F+ + M + L +++ +P QL ++
Sbjct 171 GGNGNNPNCCMNQKKDHTVTLSPSLFNPEEFMPLDPTQEPIFPPELLRLKDVPPKQLRFE 230
Query 203 GQQ--FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSI 260
G++ + T++E L+ Q+P+A++V G+T++G+ + + ++ + EL ++
Sbjct 231 GERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAV 290
Query 261 DIDQNMLHIGANVSLS-------DALSKI----SDIYPDFEELQRRFASMPIKNAGTLGG 309
+ + GA +LS +A++K+ ++++ E R FA +K+ +LGG
Sbjct 291 EHGPEGISFGAACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGG 350
Query 310 NIANGSPIGDSMPALITLDTILRLRSGEQRRDIAL-ADYYLDYQKTALQAGEFVEAILIP 368
NI SPI D P + T L + S RR + + ++ Y+KT L E + +I IP
Sbjct 351 NIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIP 410
Query 369 IHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKV-VQSINIAFGGMAAIPKRAVQA 427
F F+ +K + R E DI+ V + V+ + + +GGMA A++
Sbjct 411 YSREDEF-FSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKT 469
Query 428 EAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASS-AYRLQVAQNCLQRFYL 478
L K + +L+Q LA++ D +R + + +FYL
Sbjct 470 TQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYL 521
>P22985 Xanthine dehydrogenase / Xanthine oxidase [Rattus norvegicus]
Length=1331
Score = 196 bits (498), Expect = 5e-57
Identities = 153/548 (28%), Positives = 254/548 (46%), Gaps = 70/548 (13%)
Query 1 MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI 60
M+ + FF GK P T+L +LR GL GTK GC EG CGACTV+I
Sbjct 1 MTADELVFFVNGKKVVEKNADPETTLLVYLRRKLGL-----CGTKLGCGEGGCGACTVMI 55
Query 61 GELVNDQLQLR----SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHH 116
+ D+LQ + SVNAC+ + +L A+ TVE + + LHPVQ+ + H
Sbjct 56 SKY--DRLQNKIVHFSVNACLAPICSLHHVAVTTVEGI-----GNTQKLHPVQERIARSH 108
Query 117 GSQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQ------- 169
GSQCGFCTPG +MS++++ N+ P ++ + GNLCRCTGYRPIL +
Sbjct 109 GSQCGFCTPGIVMSMYTLLRNQPE-PTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGG 167
Query 170 ----------------------------KAFDYPKVMLERQNII-EALKQIQALPSLQLE 200
D+ + ++ I L +++ P +L
Sbjct 168 CCGGSGNNPNCCMNQTKDQTVSLSPSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLR 227
Query 201 YQGQQ--FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELK 258
++G++ + T++E L+ Q+P A++V G+T++G+ + ++ + EL
Sbjct 228 FEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIVCPAWIPELN 287
Query 259 SIDIDQNMLHIGANVSLS-------DALSKI----SDIYPDFEELQRRFASMPIKNAGTL 307
S+ + GA+ LS + ++K+ ++++ E R FA +K+ ++
Sbjct 288 SVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLRWFAGKQVKSVASI 347
Query 308 GGNIANGSPIGDSMPALITLDTILRLRSGEQRRDIAL-ADYYLDYQKTALQAGEFVEAIL 366
GGNI SPI D P + L L S RR + + ++ Y+KT L+ E + +I
Sbjct 348 GGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGYRKTLLRPEEILLSIE 407
Query 367 IPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKV-VQSINIAFGGMAAIPKRAV 425
IP F F+ +K + R E DI+ V + + VQ +++ FGGMA A+
Sbjct 408 IPYSKEGEF-FSAFKQASRREDDIAKVTSGMRVLFKPGTIEVQELSLCFGGMADRTISAL 466
Query 426 QAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSA-YRLQVAQNCLQRFYLEKIEDT 484
+ L K + EL+Q LA++ Q D +R + + +FYL ++
Sbjct 467 KTTPKQLSKSWNEELLQSVCAGLAEELQLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKL 526
Query 485 PMTRVDDL 492
++D+
Sbjct 527 GRADLEDM 534
>P47989 Xanthine dehydrogenase / Xanthine oxidase [Homo sapiens]
Length=1333
Score = 195 bits (495), Expect = 1e-56
Identities = 152/547 (28%), Positives = 258/547 (47%), Gaps = 69/547 (13%)
Query 1 MSQRPVTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVI 60
M+ + FF G+ P T+L +LR GL +GTK GC EG CGACTV++
Sbjct 1 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGL-----SGTKLGCGEGGCGACTVML 55
Query 61 GELVNDQLQLR----SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHH 116
+ D+LQ + S NAC+ + +L A+ TVE + S+++ LHPVQ+ + + H
Sbjct 56 SKY--DRLQNKIVHFSANACLAPICSLHHVAVTTVEGIG----STKTRLHPVQERIAKSH 109
Query 117 GSQCGFCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQ------- 169
GSQCGFCTPG +MS++++ N+ P ++ + GNLCRCTGYRPIL +
Sbjct 110 GSQCGFCTPGIVMSMYTLLRNQPE-PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGG 168
Query 170 ----------------------------KAFDYPKVMLERQNII-EALKQIQALPSLQLE 200
K ++ + ++ I L +++ P QL
Sbjct 169 CCGGDGNNPNCCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLR 228
Query 201 YQGQQ--FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELK 258
++G++ + T++E L+ Q+P A++V G+T++G+ + ++ + EL
Sbjct 229 FEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELN 288
Query 259 SIDIDQNMLHIGANVSLS-------DALSKI----SDIYPDFEELQRRFASMPIKNAGTL 307
S++ + + GA LS DA++K+ ++++ E R FA +K+ ++
Sbjct 289 SVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASV 348
Query 308 GGNIANGSPIGDSMPALITLDTILRLRSGEQRRDIAL-ADYYLDYQKTALQAGEFVEAIL 366
GGNI SPI D P + L L S RR + + ++ Y+KT L E + +I
Sbjct 349 GGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIE 408
Query 367 IPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKV-VQSINIAFGGMAAIPKRAV 425
IP +S + F+ +K + R E DI+ V + VQ + + +GGMA A+
Sbjct 409 IP-YSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISAL 467
Query 426 QAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASSA-YRLQVAQNCLQRFYLEKIEDT 484
+ L K+ EL+Q LA++ D +R + + +FYL ++
Sbjct 468 KTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKL 527
Query 485 PMTRVDD 491
++D
Sbjct 528 GQENLED 534
>P22811 Xanthine dehydrogenase [Drosophila pseudoobscura pseudoobscura]
Length=1343
Score = 194 bits (493), Expect = 2e-56
Identities = 158/539 (29%), Positives = 247/539 (46%), Gaps = 83/539 (15%)
Query 6 VTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVN 65
+ FF GK P T+L +LR D++R GTK GCAEG CGACTVVI +
Sbjct 10 LVFFVNGKKVTDTNPDPECTLLTYLR-----DKLRLCGTKLGCAEGGCGACTVVISRMDR 64
Query 66 DQLQLR--SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFC 123
Q ++R +VNAC+ + + G A+ TVE + S+ + LHPVQ+ + + HGSQCGFC
Sbjct 65 GQNKIRHLAVNACLTPVCAMHGCAVTTVEGIG----STRTRLHPVQERLAKAHGSQCGFC 120
Query 124 TPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPIL------------------ 165
TPG +MS++++ + + P + GNLCRCTGYRPIL
Sbjct 121 TPGIVMSMYALLRS-AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGDKC 179
Query 166 -----------DAAQKAFDYPKVMLERQNI--IEALKQIQALPSLQL--EYQGQQ----- 205
D Q D + ER ++ ++ P LQL Y +
Sbjct 180 CKVNGKGCGGGDDTQSVTD--DTLFERSQFQPLDPSQEPIFPPELQLTPTYDSESLIFSS 237
Query 206 ----FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSID 261
++ P T+QE L+ +P A++V G+T+VG+ V ++ QV EL +
Sbjct 238 ERVTWYRPTTLQELLQLKSDHPSAKLVVGNTEVGVEVKFKHFLYPHLINPTQVPELLEVR 297
Query 262 IDQNMLHIGANVSLSDALSKISDIYPDFEELQRR-----------FASMPIKNAGTLGGN 310
+ ++ GA VSL + + + + E Q R FA I+N LGGN
Sbjct 298 ESEESIYFGAAVSLMEIDALLRQRIEELPEAQTRLFQCAVDMLHYFAGKQIRNVACLGGN 357
Query 311 IANGSPIGDSMPALITLDTILRLRS----GEQRRDIAL-ADYYLDYQKTALQAGEFVEAI 365
I GSPI D P L L + S R + + ++ Y++ ++ E +
Sbjct 358 IMTGSPISDMNPVLTAAGARLEVASLVGGKTSHRTVHMGTGFFTGYRRNVIEPHE----V 413
Query 366 LIPIHSSKTF---KFATYKISKRFEQDISAVCAAFSCELD-ENKVVQSINIAFGGMAAIP 421
L+ IH KT +K ++R + DI+ V AA + + VV I++AFGGMA
Sbjct 414 LLGIHFQKTTPDQHVVAFKQARRRDDDIAIVNAAVNVRFEPRTNVVAGISMAFGGMAPTT 473
Query 422 KRAVQAEAVLLGKVMSAELIQHAQVALAQDFQPLSDGRASS--AYRLQVAQNCLQRFYL 478
A + +++ + + L++ +L + PL+ AYR + + + + YL
Sbjct 474 VLAPRTSQLMVKQPLDHHLVERVAESLCGEL-PLAASAPGGMIAYRRALVVSLIFKAYL 531
>Q00519 Xanthine dehydrogenase / Xanthine oxidase [Mus musculus]
Length=1335
Score = 191 bits (484), Expect = 4e-55
Identities = 152/533 (29%), Positives = 250/533 (47%), Gaps = 70/533 (13%)
Query 6 VTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVN 65
+ FF GK P T+L +LR GL GTK GC EG CGACTV+I +
Sbjct 9 LVFFVNGKKVVEKNADPETTLLVYLRRKLGL-----CGTKLGCGEGGCGACTVMISKY-- 61
Query 66 DQLQLR----SVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCG 121
D+LQ + SVNAC+ + +L A+ TVE + + LHPVQ+ + + HGSQCG
Sbjct 62 DRLQNKIVHFSVNACLTPICSLHHVAVTTVEGI-----GNTKKLHPVQERIAKSHGSQCG 116
Query 122 FCTPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAAQK----------A 171
FCTPG +MS++++ N+ P ++ + GNLCRCTGYRPIL + +
Sbjct 117 FCTPGIVMSMYTLLRNKPE-PTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGS 175
Query 172 FDYPKVMLER---QNIIEA-----------------------LKQIQALPSLQLEYQGQQ 205
+ P + + Q I + L +++ P L ++G++
Sbjct 176 GNNPNCCMSQTKDQTIAPSSSLFNPEDFKPLDPTQEPIFPPELLRLKDTPRKTLRFEGER 235
Query 206 --FFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSIDID 263
+ T++E L+ Q+P A++V G+T++G+ + ++ + EL S+
Sbjct 236 VTWIQVSTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIICPAWILELTSVAHG 295
Query 264 QNMLHIGANVSLS-------DALSKI----SDIYPDFEELQRRFASMPIKNAGTLGGNIA 312
+ GA LS DA++ + ++++ E R FA +K+ ++GGNI
Sbjct 296 PEGISFGAACPLSLVESVLADAIATLPEQRTEVFRGVMEQLRWFAGKQVKSVASIGGNII 355
Query 313 NGSPIGDSMPALITLDTILRLRSGEQRRDIAL-ADYYLDYQKTALQAGEFVEAILIPIHS 371
SPI D P L+ L L S +R + + ++ Y++T L E + +I+IP +S
Sbjct 356 TASPISDLNPVLMASRAKLTLASRGTKRTVWMDHTFFPGYRRTLLSPEEILVSIVIP-YS 414
Query 372 SKTFKFATYKISKRFEQDISAVCAAFSCELDENKV-VQSINIAFGGMAAIPKRAVQAEAV 430
K F+ +K + R E DI+ V + VQ +++ FGGMA A++
Sbjct 415 RKGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELSLCFGGMADRTVSALKTTPK 474
Query 431 LLGKVMSAELIQHAQVALAQDFQPLSDGRASSA-YRLQVAQNCLQRFYLEKIE 482
L K + EL+Q LA++ D +R + + +FYL ++
Sbjct 475 QLSKSWNEELLQDVCAGLAEELHLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQ 527
>Q6AUV1 Xanthine dehydrogenase [Oryza sativa subsp. japonica]
Length=1369
Score = 164 bits (415), Expect = 4e-46
Identities = 131/505 (26%), Positives = 236/505 (47%), Gaps = 90/505 (18%)
Query 24 MTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIG--ELVNDQLQLRSVNACIQFLP 81
+T+LQ+LR+ G GTK GC EG CGACTV++ + + Q ++NAC+ L
Sbjct 40 LTLLQYLRDIG------LPGTKLGCGEGGCGACTVMVSCYDQTTKKTQHFAINACLAPLY 93
Query 82 TLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFCTPGFIMSLWSMYENESHA 141
+++G + TVE + + + LHP+Q+ + HGSQCGFCTPGF+MS++++ +
Sbjct 94 SVEGMHIITVEGIG----NRQRGLHPIQERLAMAHGSQCGFCTPGFVMSMYALLRSSEQP 149
Query 142 PDKAKVS---------------------------DYLSGN----------LCRCTGYRPI 164
P + ++ D L N +C TG +P
Sbjct 150 PTEEQIEDSLAGNLCRCTGYRPIIDAFRVFSKRDDLLYNNSSLKNADGRPICPSTG-KPC 208
Query 165 LDAAQKAFDYPKVML---------------------ERQNIIEALKQIQALPSLQLE-YQ 202
QK + + L E++ I Q++ + SL+L +
Sbjct 209 SCGDQKDINGSESSLLTPTKSYSPCSYNEIDGNAYSEKELIFPPELQLRKVTSLKLNGFN 268
Query 203 GQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSIDI 262
G +++ P +++ L+ YP A+++ G+++VG+ ++ + V EL ++ +
Sbjct 269 GIRWYRPLKLKQVLHLKACYPNAKLIIGNSEVGVETKFKNAQYKVLISVTHVPELHTLKV 328
Query 263 DQNMLHIGANVSLSDA--------LSKISDIYPDFEELQRR---FASMPIKNAGTLGGNI 311
++ +HIG++V L+ L + S E + R+ FA I+N ++GGNI
Sbjct 329 KEDGIHIGSSVRLAQLQNFLRKVILERDSHEISSCEAILRQLKWFAGTQIRNVASVGGNI 388
Query 312 ANGSPIGDSMPA-LITLDTILRLRSGEQRRDIALADYYLDYQKTALQAGEFVEAILIPIH 370
SPI D P + T T + R I D++L Y+K L+ E + ++++P
Sbjct 389 CTASPISDLNPLWMATGATFEIIDVNNNIRTIPAKDFFLGYRKVDLKPDEILLSVILP-- 446
Query 371 SSKTFKFA-TYKISKRFEQDISAVCA---AFSCELDENKVVQSINIAFGGMAAIPKRAVQ 426
++ F+F +K + R E DI+ V A + +++ + ++ ++I +GG+AA+ RA +
Sbjct 447 WTRPFEFVKEFKQAHRREDDIALVNAGMRVYIRKVEGDWIISDVSIIYGGVAAVSHRASK 506
Query 427 AEAVLLGKVMSAELIQHAQVALAQD 451
E L GK L+ L +D
Sbjct 507 TETFLTGKKWDYGLLDKTFDLLKED 531
Score = 20.0 bits (40), Expect = 6.6
Identities = 9/28 (32%), Positives = 16/28 (57%), Gaps = 0/28 (0%)
Query 208 APKTVQEFAALRQQYPQARIVAGSTDVG 235
AP+ Q++ A PQ+R+V + +G
Sbjct 805 APQKHQKYVANVLGLPQSRVVCKTKRIG 832
>Q8GUQ8 Xanthine dehydrogenase 1 [Arabidopsis thaliana]
Length=1361
Score = 162 bits (409), Expect = 2e-45
Identities = 133/503 (26%), Positives = 226/503 (45%), Gaps = 89/503 (18%)
Query 24 MTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVNDQLQLRSV----NACIQF 79
MT+L++LR+ G TGTK GC EG CGACTV++ D+ SV NAC+
Sbjct 35 MTLLEYLRDLG------LTGTKLGCGEGGCGACTVMVSSY--DRKSKTSVHYAVNACLAP 86
Query 80 LPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFCTPGFIMSLWSMYENES 139
L +++G + ++E L L LHPVQ+++ HGSQCGFCTPGFIMS++S+ +
Sbjct 87 LYSVEGMHVISIEGLGHRKLG----LHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSK 142
Query 140 HAPDK---------------------------AKVSDYL------------------SGN 154
++P + AK D L +G
Sbjct 143 NSPSEEEIEECLAGNLCRCTGYRPIVDAFRVFAKSDDALYCGVSSLSLQDGSTICPSTGK 202
Query 155 LCRCTGYRPILDAAQ------KAFDYPKV----MLERQNIIEALKQIQALPSLQLEYQGQ 204
C C G + + A ++ Y + +++ I ++ L L+L G
Sbjct 203 PCSC-GSKTTNEVASCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGG 261
Query 205 -QFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLGDMLYIGQVQELKSIDID 263
++ P +Q L+ YP A+++ G+T+VG+ + ++ + QV EL +++++
Sbjct 262 ITWYRPVCLQNLLELKANYPDAKLLVGNTEVGIEMRLKRLQYQVLISVAQVPELNALNVN 321
Query 264 QNMLHIGANVSLSDALSKISDIYPD-----------FEELQRRFASMPIKNAGTLGGNIA 312
N + +G+ + LS+ L I + F E + FA I+N +GGNI
Sbjct 322 DNGIEVGSALRLSELLRLFRKIVKERPAHETSACKAFIEQLKWFAGTQIRNVACIGGNIC 381
Query 313 NGSPIGDSMPALITLDTILRLRS-GEQRRDIALADYYLDYQKTALQAGEFVEAILIPIHS 371
SPI D P + R+ + R I D++L Y+K + + E + ++ +P
Sbjct 382 TASPISDLNPLWMASRAEFRITNCNGDVRSIPAKDFFLGYRKVDMGSNEILLSVFLPWTR 441
Query 372 SKTFKFATYKISKRFEQDISAVCAAFSCELD---ENKVVQSINIAFGGMAAIPKRAVQAE 428
+ +K + R + DI+ V L+ + V +IA+GG+A + A + E
Sbjct 442 PLEY-VKEFKQAHRRDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTE 500
Query 429 AVLLGKVMSAELIQHAQVALAQD 451
L+GK + +L+Q A + D
Sbjct 501 EFLIGKNWNKDLLQDALKVIQSD 523
>R4ZGN4 Xanthine dehydrogenase [Blastobotrys adeninivorans]
Length=1405
Score = 144 bits (364), Expect = 1e-39
Identities = 73/165 (44%), Positives = 103/165 (62%), Gaps = 12/165 (7%)
Query 6 VTFFFRGKTQQVAGVAPVMTVLQFLREHGGLDQVRQTGTKEGCAEGDCGACTVVIGELVN 65
+TF+ G + ++ P T+L F+R H GL TGTK GC+EG CGACTVV+
Sbjct 19 LTFYVNGVKRTISNPDPRGTLLDFIRTHEGL-----TGTKLGCSEGGCGACTVVVASWDR 73
Query 66 DQLQL--RSVNACIQFLPTLDGKALFTVEDLKTLTLSSESVLHPVQQAMVEHHGSQCGFC 123
+Q ++ +VN+CI L ++GK L TVE + S + HP Q+ + HGSQCGFC
Sbjct 74 EQGEIIYSAVNSCIVPLVAVEGKHLITVEGI-----GSSNNPHPAQERIALFHGSQCGFC 128
Query 124 TPGFIMSLWSMYENESHAPDKAKVSDYLSGNLCRCTGYRPILDAA 168
TPG +MSL+++ N P K ++++ GNLCRCTGY+PI+DAA
Sbjct 129 TPGIVMSLYALLRNTGGQPSKEQIAESFDGNLCRCTGYKPIIDAA 173
Score = 118 bits (296), Expect = 6e-31
Identities = 96/340 (28%), Positives = 162/340 (48%), Gaps = 29/340 (9%)
Query 187 ALKQIQALPSLQLEYQGQQFFAPKTVQEFAALRQQYPQARIVAGSTDVGLWVTKLGRDLG 246
ALK+ + P L + + +F P T + ++ YP+++IV G++++ + + +
Sbjct 277 ALKKYELNP-LFFGNEQKVWFRPVTKLQLLQIKHAYPESKIVGGASEIQIEIKMKAANYN 335
Query 247 DMLYIGQVQELKSID-IDQNMLHIGANVSLS------DAL-----SKISDIYPDFEELQR 294
+Y ++ELK+ I L GAN+SLS D L +S IY E +
Sbjct 336 ISVYANDIEELKTHKYIPGKGLEFGANISLSKLEEVCDKLVHELDPNVSQIYGAILEQLK 395
Query 295 RFASMPIKNAGTLGGNIANGSPIGDSMPALITLDTILRLRSGEQRRD-IALADYYLDYQK 353
FA I+NA T GNIA SPI D P L+ + +L + S E + I++ D+++ Y+K
Sbjct 396 YFAGRQIRNAATPAGNIATASPISDLNPVLVAAEAVLTVESIENGEEQISMTDFFVGYRK 455
Query 354 TALQAGEFVEAILIPIHSSKTFKFATYKISKRFEQDISAVCAAFSCELDENKVVQSINIA 413
T L A + I +P + YK +KR + DI+ V A LD++ + +A
Sbjct 456 TKLPAHGVITKIFVPETVPRNEVVMAYKQAKRKDDDIAIVTACLRLALDDDFRISKARLA 515
Query 414 FGGMAAIPKRAVQAEAVLLGKVM----SAELIQHAQVALAQDFQ-PLSDGRASSAYRLQV 468
+GG+ A L GK++ + E+++ A L ++F P S +AYR +
Sbjct 516 YGGVGPFTTAAKGTAEFLTGKLLRRETAKEVLEGAIDCLIKEFDLPYSVPGGMAAYRRTL 575
Query 469 AQNCLQRFY---LEKI-------EDTPMTRVDDLIALVEV 498
+ +FY LEKI +++ + D AL+EV
Sbjct 576 IMSFFYKFYSTVLEKIGLAGEAQDNSALENTYDPQALLEV 615
Lambda K H a alpha
0.322 0.136 0.393 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 6820440
Database: 3b903f0d7894967b7699045fbf4adaf6.SwissProt.fasta
Posted date: May 30, 2024 5:11 AM
Number of letters in database: 16,209
Number of sequences in database: 12
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
