BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 400069791b3ca29fe01a93f64bf356cd.SwissProt.fasta
17 sequences; 8,373 total letters
Query= ACIAD2552
Length=413
Score E
Sequences producing significant alignments: (Bits) Value
P40875 Sarcosine oxidase subunit beta [Corynebacterium sp. (strai... 338 1e-116
Q52671 Sarcosine oxidase subunit beta [Rhodobacter capsulatus (st... 337 3e-116
Q9AGP3 Sarcosine oxidase subunit beta [Arthrobacter sp] 335 8e-116
O87388 Sarcosine oxidase subunit beta [Rhizobium meliloti (strain... 317 1e-108
Q8NCN5 Pyruvate dehydrogenase phosphatase regulatory subunit, mit... 108 2e-28
Q0BUV2 D-amino acid dehydrogenase [Granulibacter bethesdensis (st... 99.4 6e-26
O31616 Glycine oxidase [Bacillus subtilis (strain 168)] 89.7 7e-23
A5F3D0 D-amino acid dehydrogenase [Vibrio cholerae serotype O1 (s... 89.4 1e-22
Q64380 Sarcosine dehydrogenase, mitochondrial [Rattus norvegicus] 88.6 6e-22
C3LT39 D-amino acid dehydrogenase [Vibrio cholerae serotype O1 (s... 87.4 6e-22
Q9KTV1 D-amino acid dehydrogenase [Vibrio cholerae serotype O1 (s... 87.4 6e-22
Q9UL12 Sarcosine dehydrogenase, mitochondrial [Homo sapiens] 87.0 2e-21
O85228 Hydrogen cyanide synthase subunit HcnC [Pseudomonas proteg... 81.6 5e-20
Q5L2C2 Glycine oxidase [Geobacillus kaustophilus (strain HTA426)] 79.3 2e-19
G3XD12 Hydrogen cyanide synthase subunit HcnC [Pseudomonas aerugi... 79.3 3e-19
P23342 Monomeric sarcosine oxidase [Bacillus sp. (strain NS-129)] 74.3 1e-17
S5FMM4 Glycine oxidase [Bacillus licheniformis] 72.0 6e-17
>P40875 Sarcosine oxidase subunit beta [Corynebacterium sp. (strain
P-1)]
Length=405
Score = 338 bits (866), Expect = 1e-116
Identities = 174/389 (45%), Positives = 235/389 (60%), Gaps = 1/389 (0%)
Query 25 ELKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTS 84
E K YDVVI+GGGGHGLA AYYL+K HGI+NVAVLEK +L GGN ARNT +IRSNYL
Sbjct 17 EPKKSYDVVIVGGGGHGLATAYYLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWD 76
Query 85 DGVKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEM 144
+ Y +S+++++ L E D++ ++S+RG L LAHT VR +R E NK G E
Sbjct 77 ESAGIYEKSLKLWEQLPEELDYDFLFSQRGVLNLAHTLGDVRESVRRVEANKFNGVDAEW 136
Query 145 IDRKQIKELVPCLNL-DPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTE 203
+ +Q+KE+ P +N+ D PV+ + A+HD VAW +A++A + GV+I Q E
Sbjct 137 LTPEQVKEVCPIINIGDDIRYPVMGATYQPRAGIAKHDHVAWAFARKANEMGVDIIQNCE 196
Query 204 VQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAMVSQPF 263
V F+ G KVT VKT RG + G V A AG SS+L PI ++PLQA+VS+ F
Sbjct 197 VTGFLKDGEKVTGVKTTRGTIHAGKVALAGAGHSSVLAELAGFELPIQSHPLQALVSELF 256
Query 264 KPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFM 323
+P +V S+ +H YV Q +GE+V G G D Y Y R + E +A A+E+FP
Sbjct 257 EPVHPTVVMSNHIHVYVSQAHKGELVMGAGIDSYNGYGQRGAFHVIEEQMAAAVELFPIF 316
Query 324 ANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKTMAELVATGR 383
A ++R W G+ D T D SPI+ K+P N Y++ GWGT GFK TP G T+A +A
Sbjct 317 ARAHVLRTWGGIVDTTMDASPIISKTPIQNLYVNCGWGTGGFKGTPGAGFTLAHTIANDE 376
Query 384 TPDLIKPFELSRFSRFQQVNEMGATAASH 412
L PF L RF ++E GA A +H
Sbjct 377 AHALNAPFSLERFETGHLIDEHGAAAVAH 405
>Q52671 Sarcosine oxidase subunit beta [Rhodobacter capsulatus
(strain ATCC BAA-309 / NBRC 16581 / SB1003)]
Length=414
Score = 337 bits (864), Expect = 3e-116
Identities = 168/388 (43%), Positives = 239/388 (62%), Gaps = 1/388 (0%)
Query 25 ELKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTS 84
E K YDV+++G GGHGLA AYYL K HGI NVA++EK +LGGGNT RNT +IRSNYL
Sbjct 28 EPKKRYDVIVVGAGGHGLATAYYLGKVHGIKNVAIIEKGWLGGGNTGRNTTIIRSNYLQD 87
Query 85 DGVKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEM 144
Y ++ +++ LS + ++N+M+S RG L LA ++ +R +++ N T
Sbjct 88 PSAAIYEKARSLYEGLSQDLNYNVMFSPRGLLMLAQSEHEMRGYKRTVYANNLQNVETRW 147
Query 145 IDRKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEV 204
I+ K++K+LVP LN+ PVL L G TARHDAVAWGYA+ + G+++ Q TEV
Sbjct 148 IEPKEVKKLVPILNIAGPRYPVLGALLQEKGGTARHDAVAWGYARACSDMGMDLLQNTEV 207
Query 205 QDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAMVSQPFK 264
+G +V V T+RG + CG + +AG SS+L R PI + LQA VS+P K
Sbjct 208 TGVRTEGGRVVGVDTSRGSIDCGKLAIVVAGHSSVLAGMAGFRLPIESMALQAWVSEPIK 267
Query 265 PFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFMA 324
P I+ +V ++ +H Y+ Q+ +GE+V GGG+D + Y+ R + E IE FP ++
Sbjct 268 PTIDVVVMANLVHGYMSQSDKGELVIGGGTDGFNNYSQRGSWHHVEETTRALIETFPVIS 327
Query 325 NVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKTMAELVATGRT 384
+K++RQW G+ DMT D SPI+ K+P D +++ GWGT GFK+ P G MAELVA G +
Sbjct 328 RLKMLRQWGGIVDMTGDRSPILSKTPVDGIFVNCGWGTGGFKAIPGSGFAMAELVAKGYS 387
Query 385 PDLIKPFELSRFSRFQQVNEMGATAASH 412
P L F L RF Q ++E A +H
Sbjct 388 P-LAAEFGLHRFKEGQFIDESVAAGVAH 414
>Q9AGP3 Sarcosine oxidase subunit beta [Arthrobacter sp]
Length=405
Score = 335 bits (860), Expect = 8e-116
Identities = 173/389 (44%), Positives = 234/389 (60%), Gaps = 1/389 (0%)
Query 25 ELKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTS 84
E K YDVVI+GGGGHGLA AYYL+K HGI+NVAVLEK +L GGN ARNT +IRSNYL
Sbjct 17 EPKKSYDVVIVGGGGHGLATAYYLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWD 76
Query 85 DGVKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEM 144
+ Y +S+++++ L E D++ ++S+RG L LAHT VR +R E NK G E
Sbjct 77 ESAGIYEKSLKLWEQLPEELDYDFLFSQRGVLNLAHTLGDVRESIRRVEANKFNGVDAEW 136
Query 145 IDRKQIKELVPCLNL-DPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTE 203
+ +Q+KE+ P +N+ D PV+ + A+HD VAW +A++A + GV+I Q E
Sbjct 137 LTPEQVKEVCPIINIGDDIRYPVMGATYQPRAGIAKHDHVAWAFARKANEMGVDIIQNCE 196
Query 204 VQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAMVSQPF 263
V F+ G KVT VKT RG + G V A AG SS+L PI ++PLQA+VS+ F
Sbjct 197 VTGFLKDGEKVTGVKTTRGTIHAGKVALAGAGHSSVLAELAGFELPIQSHPLQALVSELF 256
Query 264 KPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFM 323
+P +V S+ +H YV Q +GE+V G G D Y Y R + E +A A+E+FP
Sbjct 257 EPVHPTVVMSNHIHVYVSQAHKGELVMGAGIDTYNGYGQRGAFHVIEEQMAAAVELFPIF 316
Query 324 ANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKTMAELVATGR 383
A ++R W G+ D T D PI+ K+P N Y++ GWGT GFK TP G T+A +A
Sbjct 317 ARAHVLRTWGGIVDTTMDALPIISKTPIQNLYVNCGWGTGGFKGTPGAGFTLAHTIANDE 376
Query 384 TPDLIKPFELSRFSRFQQVNEMGATAASH 412
L PF L RF ++E GA A +H
Sbjct 377 AHALNAPFSLERFETGHLIDEHGAAAVAH 405
>O87388 Sarcosine oxidase subunit beta [Rhizobium meliloti (strain
1021)]
Length=416
Score = 317 bits (813), Expect = 1e-108
Identities = 166/383 (43%), Positives = 230/383 (60%), Gaps = 0/383 (0%)
Query 27 KSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTSDG 86
K HYDV+I+GGGGHGLA AYYL+K GI+NVAVLEK+Y+G GN RNT +IRSNYL
Sbjct 29 KPHYDVIIVGGGGHGLATAYYLAKEFGITNVAVLEKNYIGSGNVGRNTTIIRSNYLLPGN 88
Query 87 VKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEMID 146
FY S+++++ L +F+FN M S+RG L L H+D+ A+ +R + G E++
Sbjct 89 NPFYELSMKLWEGLEQDFNFNAMVSQRGVLNLFHSDAQRDAYTRRGNAMRLHGVDAELLY 148
Query 147 RKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQD 206
R +++++P L+ D A P+ GL G T RHDAVAWGYA+ A RGV+I Q EV
Sbjct 149 RAAVRKMLPFLDFDNARFPIQGGLLQRRGGTVRHDAVAWGYARGADSRGVDIIQNCEVTG 208
Query 207 FVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAMVSQPFKPF 266
+ +V V+T+RG + C + A AG SS + +R PI ++ LQA VS+ KPF
Sbjct 209 IRRENGRVIGVETSRGFIGCAKLALAAAGNSSQVAEMAGLRLPIESHVLQAFVSEGLKPF 268
Query 267 INPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFMANV 326
I+ +V+ A H YV Q+ +G +VFGG D Y Y R L E + M P ++ V
Sbjct 269 IDGVVTFGAGHFYVSQSDKGGLVFGGDIDGYNSYAQRGNLATVEHVAEAGKAMIPALSRV 328
Query 327 KLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKTMAELVATGRTPD 386
+++R W G+ DM+ D SPI+ ++P DN YL+AGW GFK+TP G A L+A G
Sbjct 329 RVLRSWGGIMDMSMDGSPIIDRTPIDNLYLNAGWCYGGFKATPASGFCFAHLLARGAPQK 388
Query 387 LIKPFELSRFSRFQQVNEMGATA 409
F L RF R ++E G A
Sbjct 389 TAAAFRLDRFERGFLIDEKGQGA 411
>Q8NCN5 Pyruvate dehydrogenase phosphatase regulatory subunit,
mitochondrial [Homo sapiens]
Length=879
Score = 108 bits (270), Expect = 2e-28
Identities = 102/394 (26%), Positives = 176/394 (45%), Gaps = 27/394 (7%)
Query 26 LKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTSD 85
L + VVI GGG G ++AY+LSK G ++ +LE+ L G+T ++ + +
Sbjct 39 LPTQAQVVICGGGITGTSVAYHLSKM-GWKDIVLLEQGRLAAGSTRFCAGILSTARHLTI 97
Query 86 GVKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHT-DSTVRAFRQRAEVNKHFGGRTEM 144
K S +++ L E Y+ G + LA T D + R A +N G +E+
Sbjct 98 EQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNV-IGIPSEI 156
Query 145 IDRKQIKELVPCLNLDPAHLPVLAGLWHI-DGATARHDAVAWGYAKEAAKRGVEIHQLTE 203
I K++ EL LN+ L G H+ + A VA A A++ GV+I+ T
Sbjct 157 ISPKKVAELHHLLNVHD-----LVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTS 211
Query 204 VQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSI---LMNKLKIRAPIHTYPLQAMVS 260
V +V+ +VT V+T++G ++C V AG + L N+ + P+H +++
Sbjct 212 VLHVMVKKGQVTGVETDKGQIECQYFVNC-AGQWAYELGLSNEEPVSIPLHACEHFYLLT 270
Query 261 QPFKPFI---NPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLY----------NTRSTLD 307
+P + + P + + Y++ G + G +P P++ N + D
Sbjct 271 RPLETPLQSSTPTIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWD 330
Query 308 LKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYYLDAGWGTWGFK 366
E LL+ + P + +++M+ TPD IMG+SP Y++ AG + G
Sbjct 331 HFEPLLSSLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLS 390
Query 367 STPICGKTMAELVATGRTPDLIKPFELSRFSRFQ 400
GK +AE + G + + +L RF Q
Sbjct 391 FGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQ 424
>Q0BUV2 D-amino acid dehydrogenase [Granulibacter bethesdensis
(strain ATCC BAA-1260 / CGDNIH1)]
Length=418
Score = 99.4 bits (246), Expect = 6e-26
Identities = 77/278 (28%), Positives = 134/278 (48%), Gaps = 7/278 (3%)
Query 112 ERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEMIDRKQIKELVPCLNLDPAHLPVLAGLW 171
ERG L L T + V K +G E++DR P L A +P++ GL
Sbjct 134 ERGTLQLFRTQKQMDHTADDIAVLKSYGVAYEVLDRAGCIAAEP--GLQWAQVPLVGGLR 191
Query 172 HIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQDFVVQGNKVTAVKTNRGMVQCGCVVQ 231
T A+ +RGV T++ F QG+K+TA++++RG + V
Sbjct 192 LPGDETGDAHLFTRELARICMERGVSFLFGTQIHGFSTQGDKITAIRSSRGDLMADAYVC 251
Query 232 AIAGASSILMNKLKIRAPIHTYPLQAM-VSQPFKPFINPLVSSSALHCY-VQQTSRGEIV 289
A+ S +L+ ++ I API YP++ ++ P + VS+ Y + T G +
Sbjct 252 ALGSYSPLLLKQIGIAAPI--YPVKGYSMTIPITDETHAPVSTVMDETYKIAITRLGNRI 309
Query 290 FGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKS 349
GG+ Y+TR + + +L E+FP ++ W+G+ MTPD +PI+G +
Sbjct 310 RVGGTAELAGYDTRLRQERRMTLEGSVKELFPDSGDLPAATFWSGLRPMTPDGTPIIGPT 369
Query 350 PYDNYYLDAGWGTWGFKSTPICGKTMAELVATGRTPDL 387
Y N +L+ G GT G+ + G+ +A+++ +G+ P++
Sbjct 370 RYRNLHLNTGHGTLGWTMSCGSGRLLADMI-SGKRPNI 406
>O31616 Glycine oxidase [Bacillus subtilis (strain 168)]
Length=369
Score = 89.7 bits (221), Expect = 7e-23
Identities = 96/379 (25%), Positives = 153/379 (40%), Gaps = 25/379 (7%)
Query 26 LKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTSD 85
+K HY+ V+IGGG G AIAYYL+K + N A+ E +GG T+ ++ ++ +
Sbjct 1 MKRHYEAVVIGGGIIGSAIAYYLAKEN--KNTALFESGTMGGRTTSAAAGMLGAHAECEE 58
Query 86 GVKFY---AESVRMFKNLSNEF----DFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHF 138
F+ S R++K L E +I G LA ++ V RQ +++
Sbjct 59 RDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDS-- 116
Query 139 GGRTEMIDRKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEI 198
++++ E P + D + + D V Y K A G EI
Sbjct 117 ---VSWYSKEEVLEKEPYASGD-----IFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEI 168
Query 199 HQLTEVQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAM 258
+ T V V + + +KT G V VV A S + +L + P++
Sbjct 169 FEHTPVL-HVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAF--LPVKGE 225
Query 259 VSQPFKPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIE 318
+ I + HCY+ G +V G P T L ES++ A
Sbjct 226 CLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGL-ESVMKKAKT 284
Query 319 MFPFMANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYL-DAGWGTWGFKSTPICGKTMAE 377
M P + N+K+ R WAG+ T D P +G+ P D+ L AG G P G +++
Sbjct 285 MLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISD 344
Query 378 LVATGR-TPDLIKPFELSR 395
L+ D + F + R
Sbjct 345 LIMNKEVNQDWLHAFRIDR 363
>A5F3D0 D-amino acid dehydrogenase [Vibrio cholerae serotype O1
(strain ATCC 39541 / Classical Ogawa 395 / O395)]
Length=421
Score = 89.4 bits (220), Expect = 1e-22
Identities = 74/305 (24%), Positives = 135/305 (44%), Gaps = 36/305 (12%)
Query 98 KNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEMIDRKQIKELVPCL 157
K L+ + + +RG L + + + A + ++ G R E+++ Q CL
Sbjct 121 KALNQTYSLDYQGRQRGTLQVFRDEKQLTAIEKDMQLLAQSGVRFELLNVAQ------CL 174
Query 158 NLDPAHLPV----LAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQDFVVQGNK 213
+P PV + GLW D T + + A ++GV H +Q V +G K
Sbjct 175 THEPGLAPVQEKLVGGLWLPDDETGDYYLFCQQLTELAKQQGVRFHFDCHIQQLVCEGKK 234
Query 214 VTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQA------MVSQPFKPFI 267
+ V+T+ G+++ V A+ S+ L+ L I P+ YP++ ++ + F P
Sbjct 235 IIGVQTDLGLLKADAYVVALGSYSTSLLKPLGIEIPV--YPVKGYSLTLPIIDEKFAPQS 292
Query 268 NPL-----VSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPF 322
+ V+ + ++ E+ G DP ++T+++ A ++FP
Sbjct 293 TVMDETYKVALTRFSDRIRVAGTAELA---GFDPAIPEARKATIEMV------ARDLFPH 343
Query 323 MANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKT--MAELVA 380
+ + W G MTPD +PI+G +PY N Y + G GT G+ T CG +A+++
Sbjct 344 GGDFAKGQFWTGFRPMTPDGTPIIGATPYTNLYTNTGHGTLGW--TMACGSASILADVLT 401
Query 381 TGRTP 385
G +P
Sbjct 402 HGESP 406
>Q64380 Sarcosine dehydrogenase, mitochondrial [Rattus norvegicus]
Length=919
Score = 88.6 bits (218), Expect = 6e-22
Identities = 91/401 (23%), Positives = 170/401 (42%), Gaps = 40/401 (10%)
Query 22 PPKELKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNY 81
P + L S +VV+IGGG G Y+L+K G+ V +LE+ L G T ++
Sbjct 60 PSQPLPSTANVVVIGGGSLGCQTLYHLAKL-GVGGVVLLERERLTSGTTWHTAGLLWQLR 118
Query 82 LTSDGVKFYAESVRMFK-NLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGG 140
+ V+ A + ++ +L E + + + G L +A + +++ + K +G
Sbjct 119 PSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQQRLDEYKRLMSLGKAYGI 178
Query 141 RTEMIDRKQIKELVPCLNLDPAHLPVLAGLWHI--DG--------ATARHDAVAWG--YA 188
+ ++ + K+L P +N+D L G ++ DG T AVA G
Sbjct 179 ESHVLSPAETKDLYPLMNVDD-----LYGTLYVPRDGTMDPAGTCTTLTRAAVARGAQVI 233
Query 189 KEAAKRGVEIHQLTEVQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRA 248
+ A G+ + DF V+ +VTAV+T G +Q CVV +S + ++
Sbjct 234 ENCAVTGIRV----RTDDFGVR--RVTAVETQHGSIQTPCVVNCAGVWASSVGRMAGVKV 287
Query 249 PIHTYPLQAMVSQPFKPFIN-PLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRST-- 305
P+ +V++ + N P V Y++ +G+ + GG + P++ +
Sbjct 288 PLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLR--LQGDALSVGGYEANPIFWDEVSDK 345
Query 306 ---------LDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYY 355
D+ + AI P + + G TPD+ P+MG++P ++
Sbjct 346 FAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFF 405
Query 356 LDAGWGTWGFKSTPICGKTMAELVATGRTPDLIKPFELSRF 396
L G+ + G CG+ +A + GR + +++ RF
Sbjct 406 LGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRF 446
>C3LT39 D-amino acid dehydrogenase [Vibrio cholerae serotype O1
(strain M66-2)]
Length=421
Score = 87.4 bits (215), Expect = 6e-22
Identities = 74/305 (24%), Positives = 134/305 (44%), Gaps = 36/305 (12%)
Query 98 KNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEMIDRKQIKELVPCL 157
K L+ + + +RG L + + + A + ++ G R E+++ Q CL
Sbjct 121 KALNQTYSLDYQGRQRGTLQVFRDEKQLTAIEKDMQLLAQSGVRFELLNVAQ------CL 174
Query 158 NLDPAHLPV----LAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQDFVVQGNK 213
+P PV + GLW D T + A ++GV H +Q V +G K
Sbjct 175 THEPGLAPVQEKLVGGLWLPDDETGDCYLFCQQLTELAKQQGVRFHFDCHIQQLVCEGKK 234
Query 214 VTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQA------MVSQPFKPFI 267
+ V+T+ G+++ V A+ S+ L+ L I P+ YP++ ++ + F P
Sbjct 235 IIGVQTDLGLLKADAYVVALGSYSTSLLKPLGIEIPV--YPVKGYSLTLPIIDEKFAPQS 292
Query 268 NPL-----VSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPF 322
+ V+ + ++ E+ G DP ++T+++ A ++FP
Sbjct 293 TVMDETYKVALTRFSDRIRVAGTAELA---GFDPAIPEARKATIEMV------ARDLFPH 343
Query 323 MANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKT--MAELVA 380
+ + W G MTPD +PI+G +PY N Y + G GT G+ T CG +A+++
Sbjct 344 GGDFAKGQFWTGFRPMTPDGTPIIGATPYTNLYTNTGHGTLGW--TMACGSASILADVLT 401
Query 381 TGRTP 385
G +P
Sbjct 402 HGESP 406
>Q9KTV1 D-amino acid dehydrogenase [Vibrio cholerae serotype O1
(strain ATCC 39315 / El Tor Inaba N16961)]
Length=421
Score = 87.4 bits (215), Expect = 6e-22
Identities = 74/305 (24%), Positives = 134/305 (44%), Gaps = 36/305 (12%)
Query 98 KNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRTEMIDRKQIKELVPCL 157
K L+ + + +RG L + + + A + ++ G R E+++ Q CL
Sbjct 121 KALNQTYSLDYQGRQRGTLQVFRDEKQLTAIEKDMQLLAQSGVRFELLNVAQ------CL 174
Query 158 NLDPAHLPV----LAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQDFVVQGNK 213
+P PV + GLW D T + A ++GV H +Q V +G K
Sbjct 175 THEPGLAPVQEKLVGGLWLPDDETGDCYLFCQQLTELAKQQGVRFHFDCHIQQLVCEGKK 234
Query 214 VTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQA------MVSQPFKPFI 267
+ V+T+ G+++ V A+ S+ L+ L I P+ YP++ ++ + F P
Sbjct 235 IIGVQTDLGLLKADAYVVALGSYSTSLLKPLGIEIPV--YPVKGYSLTLPIIDEKFAPQS 292
Query 268 NPL-----VSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPF 322
+ V+ + ++ E+ G DP ++T+++ A ++FP
Sbjct 293 TVMDETYKVALTRFSDRIRVAGTAELA---GFDPAIPEARKATIEMV------ARDLFPH 343
Query 323 MANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDAGWGTWGFKSTPICGKT--MAELVA 380
+ + W G MTPD +PI+G +PY N Y + G GT G+ T CG +A+++
Sbjct 344 GGDFAKGQFWTGFRPMTPDGTPIIGATPYTNLYTNTGHGTLGW--TMACGSASILADVLT 401
Query 381 TGRTP 385
G +P
Sbjct 402 HGESP 406
>Q9UL12 Sarcosine dehydrogenase, mitochondrial [Homo sapiens]
Length=918
Score = 87.0 bits (214), Expect = 2e-21
Identities = 87/396 (22%), Positives = 164/396 (41%), Gaps = 30/396 (8%)
Query 22 PPKELKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNY 81
P + L S +VV+IGGG G Y+L+K G+S +LE+ L G T ++
Sbjct 59 PSRPLPSTANVVVIGGGSLGCQTLYHLAKL-GMSGAVLLERERLTSGTTWHTAGLLWQLR 117
Query 82 LTSDGVKFYAESVRMF-KNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGG 140
+ V+ A + R+ + L E + + + G L +A + +++ + K +G
Sbjct 118 PSDVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGV 177
Query 141 RTEMIDRKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQ 200
+ ++ + K L P +N+D + L+ T A+ A+ RG ++ +
Sbjct 178 ESHVLSPAETKTLYPLMNVDDLY----GTLYVPHDGTMDPAGTCTTLARAASARGAQVIE 233
Query 201 LTEV-------QDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTY 253
V DF V+ +V V+T G +Q CVV +S + ++ P+
Sbjct 234 NCPVTGIRVWTDDFGVR--RVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAM 291
Query 254 PLQAMVSQPFKPFIN-PLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTR-------ST 305
+V++ + N P V Y++ +G+ + GG + P++
Sbjct 292 HHAYVVTERIEGIQNMPNVRDHDASVYLR--LQGDALSVGGYEANPIFWEEVSDKFAFGL 349
Query 306 LDLKESLLAH----AIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYYLDAGW 360
DL + AI P + + G TPD+ P+MG++P ++L G+
Sbjct 350 FDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGF 409
Query 361 GTWGFKSTPICGKTMAELVATGRTPDLIKPFELSRF 396
+ G CG+ +A + GR + +++ RF
Sbjct 410 NSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Score = 19.6 bits (39), Expect = 3.6
Identities = 12/48 (25%), Positives = 18/48 (38%), Gaps = 2/48 (4%)
Query 298 PLYNTRSTLDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPI 345
P+Y K L+ ++ K R W D+ PD SP+
Sbjct 746 PVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHA--DLRPDDSPL 791
>O85228 Hydrogen cyanide synthase subunit HcnC [Pseudomonas protegens
(strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)]
Length=417
Score = 81.6 bits (200), Expect = 5e-20
Identities = 61/214 (29%), Positives = 106/214 (50%), Gaps = 6/214 (3%)
Query 187 YAKEAAKRGVEIHQLTEVQDFVVQGNKVTAVKTN-RGMVQCGCVVQAI-AGASSILMNKL 244
Y + A + GV+++ T V + QGN+V+ VKT+ G+ +C ++ A A A+ + +
Sbjct 196 YTEGARQNGVDVYFNTNVTGVLHQGNRVSGVKTDVAGLFRCTTLINAAGAWAAELSLQAT 255
Query 245 KIRAPIHTYPLQAMVSQPFKPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRS 304
I P+ Q ++++ +N +++S CY+ Q GEI+ G ++ ++ +
Sbjct 256 GIEIPVKPVKGQILLTERMPKLLNGCLTTS--DCYMAQKDNGEILIGSTTEDKG-FDVTT 312
Query 305 TLDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSPYDNYYLDA-GWGTW 363
T L+ A+ P +A+V L R WAG+ +PD PI+G YL+A G
Sbjct 313 TYPEINGLVQGAVRCVPELAHVNLKRCWAGLRPGSPDELPILGPMDGVEGYLNACGHFRT 372
Query 364 GFKSTPICGKTMAELVATGRTPDLIKPFELSRFS 397
G ++ I G + +LV P I PF RF+
Sbjct 373 GILTSAITGVLLDKLVNEEALPLDITPFLARRFA 406
Score = 33.5 bits (75), Expect = 2e-04
Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query 29 HYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTA 71
HYDVVI GGG G + AY LSK + VA+++ G + A
Sbjct 4 HYDVVIAGGGVIGASCAYQLSKRKDL-KVALIDAKRPGNASRA 45
>Q5L2C2 Glycine oxidase [Geobacillus kaustophilus (strain HTA426)]
Length=377
Score = 79.3 bits (194), Expect = 2e-19
Identities = 96/380 (25%), Positives = 161/380 (42%), Gaps = 29/380 (8%)
Query 30 YDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVI--RSNYLTSDGV 87
YDV I+GGG G AI + L+K VA+ EK +G G ++ ++ +S + TS +
Sbjct 5 YDVAIVGGGVIGAAIGFELAKRR--HRVAIFEKGTMGSGASSAAAGMLGAQSEFSTSSPL 62
Query 88 KFYAESVR-----MFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRT 142
A R + + L +I E+G + LA T+ + + G
Sbjct 63 VPLALQSRALMPALAEELRERTGIDIGLVEKGLIKLATTEEEADDLYRHYTFWRGIGEPV 122
Query 143 EMIDRKQIKELVPCLNLDPAHLPVLAGLWHI--DGATARHD-AVAWGYAKEAAKRGVEIH 199
+ + + + E+ P L + LAG +I DG + D A A YA AA G ++
Sbjct 123 QWLTKGEALEMEPRLAAE-----ALAGAMYIPGDGQVSAPDLAAALAYA--AASAGACLY 175
Query 200 QLTEVQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQ--- 256
+ TEV D + + + T G VV IA + ++ + YP++
Sbjct 176 EYTEVFD-IRSDSSGHVLDTTGGTFAAEAVV--IASGAWAARLGARVGLSLSVYPVKGEC 232
Query 257 AMVSQPFKPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHA 316
MV P P + V + CY+ S ++ G S P ++ R + +LL A
Sbjct 233 VMVRAPV-PLLQTTVFAKN-GCYIVPKSGNRLLIGATSTP-GTFDRRVSAGGVMNLLHRA 289
Query 317 IEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYYLDAGWGTWGFKSTPICGKTM 375
+ P + + + W+G+ T D P +G+ P ++ AG G +P+ G +
Sbjct 290 AHLVPDIEQAEWVASWSGIRPQTEDGLPYLGEHPERRGLFVAAGHYRNGILLSPLTGLLV 349
Query 376 AELVATGRTPDLIKPFELSR 395
A+LV T + PF L+R
Sbjct 350 ADLVERKETAFDLAPFSLTR 369
>G3XD12 Hydrogen cyanide synthase subunit HcnC [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=417
Score = 79.3 bits (194), Expect = 3e-19
Identities = 101/416 (24%), Positives = 169/416 (41%), Gaps = 64/416 (15%)
Query 30 YDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTA----VIRSNYLTSD 85
YD+VI GGG G + AY LS+ G +AV++ GN R +A I +
Sbjct 5 YDIVIAGGGVIGASCAYQLSR-RGNLRIAVVDDKR--PGNATRASAGGLWAIGESVGLGC 61
Query 86 GVKFYA----------------------------------ESVRMFKNLSNEF------D 105
GV F+ +S ++ L E D
Sbjct 62 GVIFFRMMSSRNRREAQGAAVAVDASTPHILPPAFFDLALQSNALYPELHRELIERHGMD 121
Query 106 FNIMYSERGQLTLAHTDSTVRAFRQRAEVN-KHFGGRTEMIDRKQIKELVPCLNLDPAHL 164
F ER L D R + + H + +DR++++ P ++ AH
Sbjct 122 FKF---ERTGLKYVIQDDEDRQYAEHIVAQIPHLAEQVRWLDREELRRAEPAVS-HAAH- 176
Query 165 PVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLTEVQDFVVQGNKVTAVKT-NRGM 223
L + +A Y + A + GVE+ T V + QG +++ V+T N G+
Sbjct 177 ---GALEFLCDHQVSPFRLADAYLEAARQNGVELLPGTNVTGVLRQGRRISGVRTDNAGV 233
Query 224 VQCGCVVQAIAGASSILMNKLKI--RAPIHTYPLQAMVSQPFKPFINPLVSSSALHCYVQ 281
+ C ++ A AGA + ++++ R P+ Q ++++ +N +++S CY+
Sbjct 234 LHCRTLINA-AGAWAAELSEMATGRRIPVKPVKGQIVLTERMPRLLNGCLTTS--DCYMA 290
Query 282 QTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPD 341
Q GEI+ G ++ ++ +T L+ A+ P + V L R WAG+ +PD
Sbjct 291 QKDNGEILIGSTTEDKG-FDVSNTFPEIAGLVQGAVRCVPELQQVNLKRTWAGLRPGSPD 349
Query 342 YSPIMGKSPYDNYYLDA-GWGTWGFKSTPICGKTMAELVATGRTPDLIKPFELSRF 396
PI+G YL+A G G ++ I G + LV P I PF +RF
Sbjct 350 ELPILGPVAEVEGYLNACGHFRTGILTSAITGVLLDRLVHEETLPLDIAPFLAARF 405
>P23342 Monomeric sarcosine oxidase [Bacillus sp. (strain NS-129)]
Length=387
Score = 74.3 bits (181), Expect = 1e-17
Identities = 89/391 (23%), Positives = 162/391 (41%), Gaps = 34/391 (9%)
Query 26 LKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAV--LEKSYLGGGNTARNTAVIRSNYLT 83
+ +H+DV+++G G G+A YYL+K G+ + V + + G + +T +IR Y
Sbjct 1 MSTHFDVIVVGAGSMGMAAGYYLAK-QGVKTLLVDSFDPPHTNGSHHG-DTRIIRHAYGE 58
Query 84 S-DGVKFYAESVRMFKNLSNEFDFNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHFGGRT 142
+ V F + ++ L E I +++ G L + N H
Sbjct 59 GREYVPFALRAQELWYELEKETHHKI-FTQTGVLVYGPKGGSAFVSETMEAANIH-SLEH 116
Query 143 EMIDRKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEIHQLT 202
E+ + KQ+ + + + + ++ + + Y + A G + T
Sbjct 117 ELFEGKQLTDRWAGVEVPDNY----EAIFEPNSGVLFSENCIQAYRELAEAHGATVLTYT 172
Query 203 EVQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAMVSQP 262
V+DF V + VT +KT +G +V ++ +S L++KL + P+ Y V
Sbjct 173 PVEDFEVTEDLVT-IKTAKGSYTANKLVVSMGAWNSKLLSKLDVEIPLQPY---RQVVGF 228
Query 263 FKPFINPLVSSSALHCYVQQTSRGEIVFG----GGS-------------DPYPLYNTRST 305
F+ +++ ++ + G I +G GGS DP +
Sbjct 229 FECDEAKYSNNAHYPAFMVEVENG-IYYGFPSFGGSGLKIGYHSYGQQIDPDTINREFGA 287
Query 306 LDLKESLLAHAIEMFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYYLDAGWGTWG 364
E+ L +E + AN +L + M TPD ++ P Y N + AG+ G
Sbjct 288 YPEDEANLRKFLEQYMPGANGELKKGAVCMYTKTPDEHFVIDLHPKYSNVAIAAGFSGHG 347
Query 365 FKSTPICGKTMAELVATGRTPDLIKPFELSR 395
FK + + G+T+A+L TG+T I F L+R
Sbjct 348 FKFSSVVGETLAQLATTGKTEHDISIFSLNR 378
>S5FMM4 Glycine oxidase [Bacillus licheniformis]
Length=369
Score = 72.0 bits (175), Expect = 6e-17
Identities = 82/362 (23%), Positives = 146/362 (40%), Gaps = 24/362 (7%)
Query 26 LKSHYDVVIIGGGGHGLAIAYYLSKYHGISNVAVLEKSYLGGGNTARNTAVIRSNYLTSD 85
++ YD ++IGGG G +IAY+L+K AV E +G T+ ++ ++
Sbjct 1 MRKRYDTIVIGGGIIGTSIAYHLAKAG--KKTAVFESGEVGKKATSAAAGMLGAHAECDK 58
Query 86 GVKFYA---ESVRMFKNLSNEFD----FNIMYSERGQLTLAHTDSTVRAFRQRAEVNKHF 138
F+ S + +K L+ E +I + G L LA ++S Q ++
Sbjct 59 PGTFFEFARASQKAYKRLTGELKDISGIDIRRHDGGILKLAFSESDREHLMQMGALDS-- 116
Query 139 GGRTEMIDRKQIKELVPCLNLDPAHLPVLAGLWHIDGATARHDAVAWGYAKEAAKRGVEI 198
E ++ ++ +L P A +L + D AV +A+ A G ++
Sbjct 117 ---VEWLEADEVYKLEP-----NAGKGILGANFIRDDVHVEPAAVCRAFARGARMLGADV 168
Query 199 HQLTEVQDFVVQGNKVTAVKTNRGMVQCGCVVQAIAGASSILMNKLKIRAPIHTYPLQAM 258
+ T V + V + G + V A S L ++ + YP++
Sbjct 169 FEYTPVLSIESEAGAVRVTSAS-GTAEAEHAVIASGVWSGALFKQIGLDKRF--YPVKGE 225
Query 259 VSQPFKPFINPLVSSSALHCYVQQTSRGEIVFGGGSDPYPLYNTRSTLDLKESLLAHAIE 318
+ I+ + HCY+ G +V G P +N + L E L+ A
Sbjct 226 CLSVWNDGISLTRTLYHDHCYIVPRHSGRLVVGATMKPGD-WNEQPELGGIEELIRKAKS 284
Query 319 MFPFMANVKLMRQWAGMTDMTPDYSPIMGKSP-YDNYYLDAGWGTWGFKSTPICGKTMAE 377
M P + ++K+ + WAG+ T D +P +G+ P D AG G P G+ MA+
Sbjct 285 MLPGIESMKIDQCWAGLRPETGDGNPYIGRHPENDRILFAAGHFRNGILLAPATGEMMAD 344
Query 378 LV 379
++
Sbjct 345 MI 346
Lambda K H a alpha
0.321 0.136 0.413 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 2703529
Database: 400069791b3ca29fe01a93f64bf356cd.SwissProt.fasta
Posted date: May 16, 2024 12:51 AM
Number of letters in database: 8,373
Number of sequences in database: 17
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
