ACIAD2553 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: a3ed98e4ec81d9dcc200d1bf259ceb42.SwissProt.fasta
           20 sequences; 6,096 total letters



Query= ACIAD2553

Length=298
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q6F9E6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  579     0.0   
A4XXZ2 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  385     1e-138
A4XY05 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  377     2e-135
Q883B5 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  362     1e-129
Q48HJ1 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  357     9e-128
Q4ZUA4 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  357     9e-128
B0KLM9 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  355     4e-127
A1B5A7 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  308     1e-108
A4WQ13 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  308     2e-108
A3PM50 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  308     2e-108
Q9X7F6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  268     2e-92 
P96050 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  266     5e-92 
Q9I2U6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  262     1e-90 
P24186 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  262     2e-90 
Q60006 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  253     5e-87 
P51696 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  247     9e-85 
A2RVV7 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahyd...  244     2e-82 
P13995 NAD-dependent methylenetetrahydrofolate dehydrogenase / Me...  221     1e-73 
Q04448 NAD-dependent methylenetetrahydrofolate dehydrogenase / Me...  219     3e-73 
P18155 NAD-dependent methylenetetrahydrofolate dehydrogenase / Me...  218     2e-72 


>Q6F9E6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Acinetobacter baylyi (strain ATCC 
33305 / BD413 / ADP1)]
Length=297

 Score = 579 bits (1493),  Expect = 0.0
 Identities = 297/297 (100%), Positives = 297/297 (100%), Gaps = 0/297 (0%)

Query  1    MSLALLQQHSPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRN  60
            MSLALLQQHSPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRN
Sbjct  1    MSLALLQQHSPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRN  60

Query  61   KVQKAAFVGIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLER  120
            KVQKAAFVGIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLER
Sbjct  61   KVQKAAFVGIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLER  120

Query  121  IHPQKDVDGFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVG  180
            IHPQKDVDGFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVG
Sbjct  121  IHPQKDVDGFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVG  180

Query  181  KPMAALLLKESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGI  240
            KPMAALLLKESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGI
Sbjct  181  KPMAALLLKESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGI  240

Query  241  NRIMTHEKTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQHPQI  297
            NRIMTHEKTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQHPQI
Sbjct  241  NRIMTHEKTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQHPQI  297


>A4XXZ2 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas mendocina (strain ymp)]
Length=303

 Score = 385 bits (988),  Expect = 1e-138
 Identities = 200/286 (70%), Positives = 232/286 (81%), Gaps = 1/286 (0%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG  69
            SPK+IDGKA A  VL EV  +V   KA GI+P LAVVLVG+DPASQVYVRNKV +A   G
Sbjct  6    SPKLIDGKAAAARVLAEVTEDVRTLKAAGIKPALAVVLVGDDPASQVYVRNKVLRAEECG  65

Query  70   IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDG  129
            IRSLE +  AD +E +LL  I  LN +  VHGILVQLPLP  I+ETRVL+ I+P KDVDG
Sbjct  66   IRSLEHKLPADTAEADLLALIHSLNADYSVHGILVQLPLPAHIDETRVLQAINPLKDVDG  125

Query  130  FHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
            FH+ENVGGLSQGRDVLTPCTP GC+RLL+DS G DL+G HAVVIGRSNIVGKPMAALLLK
Sbjct  126  FHAENVGGLSQGRDVLTPCTPAGCLRLLQDSCG-DLTGKHAVVIGRSNIVGKPMAALLLK  184

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKT  249
              C+V+VVHSK+ N+ ++C+QADIVVAAVGK  +++A +LK  AVVIDVGINRI    ++
Sbjct  185  AHCSVSVVHSKSANLRELCRQADIVVAAVGKPRLVDADWLKPGAVVIDVGINRIDEGGRS  244

Query  250  RLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQHP  295
            RLVGDVDF+ AL   +AITPVPGGVGPMTIA+LMKNTL A RLQHP
Sbjct  245  RLVGDVDFDSALTRAAAITPVPGGVGPMTIAFLMKNTLVAARLQHP  290


>A4XY05 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas mendocina (strain ymp)]
Length=307

 Score = 377 bits (967),  Expect = 2e-135
 Identities = 197/282 (70%), Positives = 227/282 (80%), Gaps = 1/282 (0%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGIR  71
            K+IDGKA A  VL EV  +V   KA GI P LAVVLVG+DPASQVYVRNKV +A   GIR
Sbjct  8    KLIDGKAAAARVLAEVAEDVRALKAAGIVPALAVVLVGDDPASQVYVRNKVLRAEECGIR  67

Query  72   SLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGFH  131
            SLEF+  AD +E  L   I  LN +  VHGILVQLPLP  I+E RVL+ + P KDVDGFH
Sbjct  68   SLEFKLPADTAEARLQALIAELNADASVHGILVQLPLPAHIDEQRVLQAVTPLKDVDGFH  127

Query  132  SENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKES  191
            +ENVGGLSQGR+VLTPCTP GC+RLL+DS G DL+G HAVVIGRSNIVGKPMAALLLK  
Sbjct  128  AENVGGLSQGREVLTPCTPAGCLRLLQDSCG-DLTGKHAVVIGRSNIVGKPMAALLLKAH  186

Query  192  CTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTRL  251
            C+VTVVHSK+ N++ +C+QADIVVAAVG+  +++A +LK  AVVIDVGINRI  + ++RL
Sbjct  187  CSVTVVHSKSANLKTLCRQADIVVAAVGRPRLVDADWLKPGAVVIDVGINRIDENGRSRL  246

Query  252  VGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
            VGDVDF+ ALP VSAITPVPGGVGPMTIAYLMKNTL A RLQ
Sbjct  247  VGDVDFDSALPQVSAITPVPGGVGPMTIAYLMKNTLVAARLQ  288


>Q883B5 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas syringae pv. tomato 
(strain ATCC BAA-871 / DC3000)]
Length=300

 Score = 362 bits (928),  Expect = 1e-129
 Identities = 189/284 (67%), Positives = 226/284 (80%), Gaps = 1/284 (0%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG  69
            S +IIDGKA A  VL +V+ +V   KA+GIEP LAV+LVG DPAS+VY+RNK+ +A   G
Sbjct  2    SARIIDGKAAAARVLGQVRDDVHTLKAEGIEPALAVILVGNDPASEVYIRNKIVRAEEAG  61

Query  70   IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDG  129
            IRSLE R  AD SE  LL  I  LNT+R V+GIL+QLPLP  INE   L+ I   KDVDG
Sbjct  62   IRSLEHRLPADCSEARLLALIAELNTDRSVNGILLQLPLPAHINEAHALQAIAAAKDVDG  121

Query  130  FHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
            FHSENVGGLSQGR+VLTPCTP+GC+ LLK++ G DL+G HAVVIGRSNIVGKPMAALLL+
Sbjct  122  FHSENVGGLSQGRNVLTPCTPSGCMHLLKETCG-DLTGKHAVVIGRSNIVGKPMAALLLQ  180

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKT  249
              C+VTVVHS++ + + +CQ ADIVVAAVG+  MI+A +LK  AVVIDVGINRI    ++
Sbjct  181  AHCSVTVVHSRSTDAKALCQLADIVVAAVGRPRMIDAGWLKPGAVVIDVGINRIDDQGRS  240

Query  250  RLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
            RLVGDVDF++AL +VSAITPVPGGVGPMTIA+LMKNT+ A R Q
Sbjct  241  RLVGDVDFDNALDVVSAITPVPGGVGPMTIAFLMKNTVTAARQQ  284


>Q48HJ1 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas savastanoi pv. phaseolicola 
(strain 1448A / Race 6)]
Length=300

 Score = 357 bits (916),  Expect = 9e-128
 Identities = 186/284 (65%), Positives = 224/284 (79%), Gaps = 1/284 (0%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG  69
            S +IIDGKA A  VLE+V  EV+  KA GIEP LAV+LVG DPAS+VYVRNK+ +A   G
Sbjct  2    SARIIDGKAAAARVLEQVSTEVKILKADGIEPALAVILVGNDPASEVYVRNKILRAEEAG  61

Query  70   IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDG  129
            IRSLE R  A  S+ ++L  I  LN +  V+GIL+QLPLP  + E R L+ I P KDVDG
Sbjct  62   IRSLEHRLPAKSSQAQVLALIAELNADDSVNGILLQLPLPSHMEEARALQAIDPGKDVDG  121

Query  130  FHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
            FHSENVGGLSQGR VLTPCTP+GC+ LL+++ G DLSG HAVVIGRSNIVGKPMAALLL+
Sbjct  122  FHSENVGGLSQGRSVLTPCTPSGCMHLLEETCG-DLSGKHAVVIGRSNIVGKPMAALLLQ  180

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKT  249
              C+VTVVHS++ + + +CQ ADIVVAAVG+  MI+AS+LK  AVVIDVGINRI    ++
Sbjct  181  AHCSVTVVHSRSTDAKALCQLADIVVAAVGRPRMIDASWLKPGAVVIDVGINRIEDQGRS  240

Query  250  RLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
            RLVGD+DF++AL + SAITPVPGGVGPMTIA+LMKNT+ A R Q
Sbjct  241  RLVGDIDFDNALSVASAITPVPGGVGPMTIAFLMKNTVTAARQQ  284


>Q4ZUA4 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas syringae pv. syringae 
(strain B728a)]
Length=300

 Score = 357 bits (916),  Expect = 9e-128
 Identities = 187/284 (66%), Positives = 223/284 (79%), Gaps = 1/284 (0%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG  69
            S  IIDGKA A  VL++V+ +V   KA+GIEP LAV+LVG D AS+VYVRNK+ +A   G
Sbjct  2    SAHIIDGKAAAARVLQQVRHDVNILKAEGIEPALAVILVGNDAASEVYVRNKILRAGEAG  61

Query  70   IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDG  129
            IRSLE R  AD S+  LL  I  LN +  V+GIL+QLPLP  I+E RVL+ I P KDVDG
Sbjct  62   IRSLEHRLPADSSQARLLALIAELNADNTVNGILLQLPLPAHIDENRVLQAIDPDKDVDG  121

Query  130  FHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
            FHSENVGGLSQGR+VLTPCTP+GC+ LL+++ G DLSG HAVVIGRSNIVGKPMAALLL+
Sbjct  122  FHSENVGGLSQGRNVLTPCTPSGCLHLLEETCG-DLSGKHAVVIGRSNIVGKPMAALLLQ  180

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKT  249
              C+VTVVHS++ +   +CQ ADIVVAAVG+  +I+AS+LK  AVVIDVGINRI  H ++
Sbjct  181  AHCSVTVVHSRSTDARALCQLADIVVAAVGRPRLIDASWLKRGAVVIDVGINRIEDHGRS  240

Query  250  RLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
            RLVGDVDF  A  + SAITPVPGGVGPMTIA+LMKNT+ A R Q
Sbjct  241  RLVGDVDFASATEVASAITPVPGGVGPMTIAFLMKNTVTAARQQ  284


>B0KLM9 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas putida (strain GB-1)]
Length=303

 Score = 355 bits (912),  Expect = 4e-127
 Identities = 189/284 (67%), Positives = 223/284 (79%), Gaps = 1/284 (0%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG  69
            S K+IDGKA A  VL EV+ +V+  +  G++P L VVLVG D ASQVYVRNKV +A  VG
Sbjct  6    SLKLIDGKATAARVLAEVREQVQELRQGGVQPGLVVVLVGADAASQVYVRNKVLRAEEVG  65

Query  70   IRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDG  129
            IRS E R  AD ++  LLT IDRLN +  V+GILVQLPLP  I+E  VL+ I+P KDVDG
Sbjct  66   IRSQEHRLPADTTQAHLLTLIDRLNRDPEVNGILVQLPLPAHIDEHCVLQAINPLKDVDG  125

Query  130  FHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
            FHSENVGGL+QGRDVLTPCTP+GC+RLL+D+ G +L G HAVV+GRSNIVGKPMAALLL+
Sbjct  126  FHSENVGGLAQGRDVLTPCTPSGCMRLLRDACG-ELRGKHAVVVGRSNIVGKPMAALLLQ  184

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKT  249
              CTVTVVHS++R++  +C+QADI+VAAVGK  +I A  LK  AVVIDVGINRI    + 
Sbjct  185  ADCTVTVVHSRSRDLPALCRQADILVAAVGKPRLIGADCLKPGAVVIDVGINRINEDGQN  244

Query  250  RLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
             LVGDVDF  ALP V+ ITPVPGGVGPMTIAYLMKNTL A+ LQ
Sbjct  245  HLVGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLALDLQ  288


>A1B5A7 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Paracoccus denitrificans (strain 
Pd 1222)]
Length=298

 Score = 308 bits (790),  Expect = 1e-108
 Identities = 163/279 (58%), Positives = 202/279 (72%), Gaps = 2/279 (1%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKA-QGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            +IIDGKA A  V   V   V   +A  G+ P LAVVLVGEDPASQVYVRNK  +    G+
Sbjct  4    RIIDGKAFASGVRGRVASAVAGLEAAHGVVPGLAVVLVGEDPASQVYVRNKGIQTREAGM  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S E +  A+ ++ EL+  I+RLN +  VHGILVQLPLP+ ++   V+  I P+KDVDGF
Sbjct  64   ASFEHKLPAETAQAELMALIERLNADPAVHGILVQLPLPRHMDAEAVINAIDPKKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  NVG L  G+  + PCTP GC+ LL+D+LGD LSGL+AVV+GRSNIVGKPMA LLL E
Sbjct  124  HVLNVGLLGTGQKAMVPCTPLGCLMLLRDTLGD-LSGLNAVVVGRSNIVGKPMAQLLLNE  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
            SCTVT+ HS+TR++  +C+ ADI+VAAVG+  MI   ++K  A VIDVGINRI    ++R
Sbjct  183  SCTVTIAHSRTRDLAGLCRTADILVAAVGRPRMIRGDWIKPGATVIDVGINRIEEAGRSR  242

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA  289
            LVGDVDF+ A P+  AITPVPGGVGPMTIA L+ NTL A
Sbjct  243  LVGDVDFDSAAPVAGAITPVPGGVGPMTIACLLANTLTA  281


>A4WQ13 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Cereibacter sphaeroides (strain 
ATCC 17025 / ATH 2.4.3)]
Length=296

 Score = 308 bits (788),  Expect = 2e-108
 Identities = 167/279 (60%), Positives = 198/279 (71%), Gaps = 2/279 (1%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQ-GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            K IDGKA A  V  +V   V R KA  G+ P LAVVLVGEDPASQVYV  K ++   VG+
Sbjct  4    KRIDGKAFAAGVRAQVADHVARLKADHGLVPGLAVVLVGEDPASQVYVGAKGKQTVEVGM  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S E R  A+ SE ELL  IDRLN +  VHGILVQLPLP  +N   V+  + P KDVDGF
Sbjct  64   ASFEHRLSAETSEAELLALIDRLNRDPLVHGILVQLPLPPHLNSDLVINALDPAKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  NVG L  G+  + PCTP GC+ +L+D LG+ LSGL+AVV+GRSNIVGKPMA LLL E
Sbjct  124  HISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGN-LSGLNAVVVGRSNIVGKPMAQLLLGE  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
            SCTVT+ HS+T+++  VC+ ADI+VAAVG+  MI   ++K  A VIDVGINRI    KT+
Sbjct  183  SCTVTIAHSRTKDLAAVCRGADILVAAVGRPEMITGEFIKPGATVIDVGINRIERDGKTK  242

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA  289
            LVGDVDF  A  +  AITPVPGGVGPMTIA L+ NTL A
Sbjct  243  LVGDVDFASAAEVAGAITPVPGGVGPMTIACLLANTLTA  281


>A3PM50 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Cereibacter sphaeroides (strain 
ATCC 17029 / ATH 2.4.9)]
Length=296

 Score = 308 bits (788),  Expect = 2e-108
 Identities = 168/279 (60%), Positives = 196/279 (70%), Gaps = 2/279 (1%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYK-AQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            K IDGKA A  V   V  EV R K   GI P LAVVLVGEDPASQVYV  K ++   VG+
Sbjct  4    KRIDGKAFAAGVRARVAEEVARLKEGHGIVPGLAVVLVGEDPASQVYVGAKGKQTVEVGM  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S E R  A+ SE ELL  IDRLN +  VHGILVQLPLP  +N   V+  + P KDVDGF
Sbjct  64   ASFEHRLPAETSEAELLALIDRLNHDPAVHGILVQLPLPAHLNADLVINALDPAKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  NVG L  G+  + PCTP GC+ +L+D LG  LSGL+AVV+GRSNIVGKPMA LLL E
Sbjct  124  HISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGT-LSGLNAVVVGRSNIVGKPMAQLLLGE  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
            SCTVT+ HS+TR++  VC+ ADI+VAAVG+  MI   ++K  A VIDVGINRI    KT+
Sbjct  183  SCTVTIAHSRTRDLAAVCRGADILVAAVGRPEMITGDFVKPGATVIDVGINRIERDGKTK  242

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA  289
            LVGDVD+  A  +  AITPVPGGVGPMTIA L+ NTL A
Sbjct  243  LVGDVDYASAAEVAGAITPVPGGVGPMTIACLLANTLTA  281


>Q9X7F6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Methylorubrum extorquens (strain 
CM4 / NCIMB 13688)]
Length=306

 Score = 268 bits (684),  Expect = 2e-92
 Identities = 144/290 (50%), Positives = 195/290 (67%), Gaps = 5/290 (2%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQ-GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            ++IDG+A A  + + V+    R+  + G  P LAVVL+G+DPAS VYV+ K +KA   GI
Sbjct  4    QVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARSTGI  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S   R  +D +ED LL  ID+LN +R V GILVQLPLP  I   RVL+RI P KDVDGF
Sbjct  64   LSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  N G L+ G+  L PCTP GC+RL++ S+  +L G + VV+GRS IVG+P A + L  
Sbjct  124  HPVNAGLLATGQPGLVPCTPLGCLRLVQ-SVAAELVGQNVVVVGRSTIVGRPAAQVFLNA  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
             C+VT++H ++R++   C+ ADI+V A G   ++   ++K  AVVIDVGINRI      R
Sbjct  183  DCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSGYR  242

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTL---QAVRLQHPQI  297
            LVGDVDFE    + SAITPVPGGVGPMT+A LM+NT+   +A+ ++ P++
Sbjct  243  LVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTVACAEALAIRAPEV  292


>P96050 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Streptococcus thermophilus]
Length=284

 Score = 266 bits (679),  Expect = 5e-92
 Identities = 141/278 (51%), Positives = 189/278 (68%), Gaps = 5/278 (2%)

Query  13   IIDGKAIAQSVLEEVKLEVERYKA-QGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGIR  71
            I+DGKA+A ++ E+++ +V R K  + I P L V++VGE+PASQVYVRNK + A   G  
Sbjct  4    IMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFH  63

Query  72   SLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGFH  131
            S        +SE+EL+  I++ N     HGILVQLPLP  INE R+L  I P+KDVDGFH
Sbjct  64   SKTVNLSESISEEELIEVIEKYNQNPLFHGILVQLPLPNHINEMRILLAIDPKKDVDGFH  123

Query  132  SENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKES  191
              N G L  GR  + PCTP G + +L++    +L G  AV+IGRSNIVGKPMA LLL+++
Sbjct  124  PMNTGNLWNGRPQMVPCTPAGIMEILRE-YNVELEGKTAVIIGRSNIVGKPMAQLLLEKN  182

Query  192  CTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTRL  251
             TVT+ HS+T ++ +VC +AD+++ A+G+A  +   ++K  AVVIDVGINR    E+ +L
Sbjct  183  ATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINR---DEEGKL  239

Query  252  VGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA  289
             GDVDF+     VS ITPVPGGVGPMTI  LM+ T QA
Sbjct  240  CGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQA  277


>Q9I2U6 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Pseudomonas aeruginosa (strain 
ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 
/ 1C / PRS 101 / PAO1)]
Length=284

 Score = 262 bits (670),  Expect = 1e-90
 Identities = 145/284 (51%), Positives = 187/284 (66%), Gaps = 5/284 (2%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            ++IDGKAIA ++ +++   V   + QG+  P LAV+LVG DPASQVYV +K +    VG 
Sbjct  4    QLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVGF  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S  +   A+ S+D+LL  IDRLN +  + GILVQLPLP  ++ + +LERIHP KDVDGF
Sbjct  64   LSQAYDLPAETSQDDLLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  N+G L+Q   +L PCTP G + LL  S G DL G+ AVV+G SNIVG+PMA  LL  
Sbjct  124  HPYNIGRLAQRMPLLRPCTPKGIMTLLA-STGADLYGMDAVVVGASNIVGRPMALELLLG  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
             CTVTV H  TR++     +AD+VV A GK  ++   ++K  A+VIDVGINR       R
Sbjct  183  GCTVTVTHRFTRDLADHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINR---QADGR  239

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQH  294
            LVGDV++E A    S ITPVPGGVGPMT A L++NTL A    H
Sbjct  240  LVGDVEYEVAAQRASWITPVPGGVGPMTRACLLENTLHAAEHLH  283


>P24186 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Escherichia coli (strain K12)]
Length=288

 Score = 262 bits (669),  Expect = 2e-90
 Identities = 152/287 (53%), Positives = 184/287 (64%), Gaps = 6/287 (2%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            KIIDGK IAQ V  EV  +V+   A G+  P LAVVLVG +PASQ+YV +K +    VG 
Sbjct  4    KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S  +      SE ELL  ID LN +  + GILVQLPLP  I+  +VLERIHP KDVDGF
Sbjct  64   VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  NVG L Q    L PCTP G + LL +    D  GL+AVVIG SNIVG+PM+  LL  
Sbjct  124  HPYNVGRLCQRAPRLRPCTPRGIVTLL-ERYNIDTFGLNAVVIGASNIVGRPMSMELLLA  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
             CT TV H  T+N+    + AD+++ AVGK   I   ++K  A+VIDVGINR+   E  +
Sbjct  183  GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENGK  239

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA-VRLQHPQ  296
            +VGDV FEDA    S ITPVPGGVGPMT+A L++NTLQA V    PQ
Sbjct  240  VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ  286


>Q60006 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Salmonella typhi]
Length=288

 Score = 253 bits (646),  Expect = 5e-87
 Identities = 147/287 (51%), Positives = 183/287 (64%), Gaps = 6/287 (2%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            KIIDGK IAQ V  EV  +V+   A G+  P LAVVLVG +PASQ+YV +K +    VG 
Sbjct  4    KIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGF  63

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S  +      SE ELL  ID LN +  + GILVQLPLP  I+  +VLERI P KDVDGF
Sbjct  64   VSHSYDLPETTSEAELLALIDTLNADNTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGF  123

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            H  NVG L Q    L PCTP G + LL +    D  GL+AVVIG SNIVG+PM+  LL  
Sbjct  124  HPYNVGRLCQRAPRLRPCTPRGIVTLL-ERYNIDTYGLNAVVIGASNIVGRPMSMELLLA  182

Query  191  SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR  250
             CT TV H  T+++    + AD+++ AVGK   I   ++K  A+VIDVGINR+   E  +
Sbjct  183  GCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRL---ENGK  239

Query  251  LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA-VRLQHPQ  296
            +VGDV F++A    S ITPVPGGVGPMT+A L++NTLQA +    PQ
Sbjct  240  VVGDVVFDEAAARASYITPVPGGVGPMTVATLIENTLQACIEYHDPQ  286


>P51696 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Photobacterium phosphoreum]
Length=285

 Score = 247 bits (631),  Expect = 9e-85
 Identities = 144/286 (50%), Positives = 182/286 (64%), Gaps = 5/286 (2%)

Query  10   SPKIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFV  68
            S +IIDGK I+Q+V +EV   V+     G+  P LAVVLVG+DPASQ+YV +K +    V
Sbjct  2    SAQIIDGKIISQTVRQEVAARVKARTDAGLRAPGLAVVLVGQDPASQIYVGSKRKACEEV  61

Query  69   GIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVD  128
            G  S  F   +  SE +LL  ID LN +  + GILVQLPLP  ++ TR+LERI P+KDVD
Sbjct  62   GFISKSFDLPSSASEQQLLDLIDELNQDPTMDGILVQLPLPAGMDCTRILERIDPEKDVD  121

Query  129  GFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLL  188
            GFH  NVG LSQ    L  CTP G I LL +    ++ G HAV++G SNIVG+PM   LL
Sbjct  122  GFHPYNVGRLSQRIPKLRSCTPKGIITLL-ERYNIEVRGKHAVIVGASNIVGRPMTLELL  180

Query  189  KESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEK  248
                T T  H  T+++E   +QADI+V AVGK N I   ++K  A VIDVGINR+   E 
Sbjct  181  LAGATTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGGWIKEGATVIDVGINRL---EN  237

Query  249  TRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQH  294
             +L GDV+F+ A      ITPVPGGVGPMT+A L++NTL A    H
Sbjct  238  GKLCGDVEFDVACQRAKYITPVPGGVGPMTVASLIENTLLACEQYH  283


>A2RVV7 Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate 
cyclohydrolase [Arabidopsis thaliana]
Length=352

 Score = 244 bits (622),  Expect = 2e-82
 Identities = 136/285 (48%), Positives = 191/285 (67%), Gaps = 7/285 (2%)

Query  13   IIDGKAIAQSVLEEVKLEVERYK-AQGIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGIR  71
            +IDG  IA+ +  ++  EV + K A G  P LAVVLVGE   SQ YVRNK++     GI+
Sbjct  65   VIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGIK  124

Query  72   SLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGFH  131
            S+      D +E ++++ + + N +  +HGILVQLPLP+ +NE+++L  +  +KDVDGFH
Sbjct  125  SVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLPQHLNESKILNMVRLEKDVDGFH  184

Query  132  SENVGGLS-QGRDVL-TPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLK  189
              NVG L+ +GR+ L   CTP GC+ LL  + G +++G +AVVIGRSNIVG PM+ LL +
Sbjct  185  PLNVGNLAMRGREPLFVSCTPKGCVELLIRT-GVEIAGKNAVVIGRSNIVGLPMSLLLQR  243

Query  190  ESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHE--  247
               TV+ VH+ T++ E + ++ADIV+AA G  N++  S+LK  AVVIDVG   +      
Sbjct  244  HDATVSTVHAFTKDPEHITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSSCE  303

Query  248  -KTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVR  291
               RLVGDV +E+AL + SAITPVPGGVGPMTI  L+ NTL+A +
Sbjct  304  FGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLEAAK  348


>P13995 NAD-dependent methylenetetrahydrofolate dehydrogenase 
/ Methenyltetrahydrofolate cyclohydrolase [Homo sapiens]
Length=350

 Score = 221 bits (563),  Expect = 1e-73
 Identities = 133/292 (46%), Positives = 177/292 (61%), Gaps = 14/292 (5%)

Query  13   IIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGIR  71
            +I G+ +AQ + +EV+ EVE + A G + P L+V+LVGE+PAS  YV NK + AA VGI 
Sbjct  39   VISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGIN  98

Query  72   SLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGFH  131
            S      A +SE+ELL  I++LN +  V G+LVQLPLP+ I+E R+   + P KDVDGFH
Sbjct  99   SETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFH  158

Query  132  SENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE-  190
              NVG +   +  + P TP G   ++K + G    G + VV GRS  VG P+A LL  + 
Sbjct  159  VINVGRMCLDQYSMLPATPWGVWEIIKRT-GIPTLGKNVVVAGRSKNVGMPIAMLLHTDG  217

Query  191  -------SCTVTVVHSKT--RNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGIN  241
                     TVT+ H  T    +++    ADIV++A G  N+I A  +K  A VIDVGIN
Sbjct  218  AHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGIN  277

Query  242  RI--MTHEKTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVR  291
            R+      K +LVGDVDFE        ITPVPGGVGPMT+A LMKNT+ A +
Sbjct  278  RVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK  329


>Q04448 NAD-dependent methylenetetrahydrofolate dehydrogenase 
/ Methenyltetrahydrofolate cyclohydrolase [Drosophila melanogaster]
Length=309

 Score = 219 bits (557),  Expect = 3e-73
 Identities = 136/295 (46%), Positives = 177/295 (60%), Gaps = 14/295 (5%)

Query  12   KIIDGKAIAQSVLEEVKLEVERYKAQGI-EPCLAVVLVGEDPASQVYVRNKVQKAAFVGI  70
            +IIDGKAIAQ V  ++  E++  +A G  +P L  V+VGEDPAS+ YV NK+     VGI
Sbjct  9    QIIDGKAIAQEVRTQLAHELKGMEAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGI  68

Query  71   RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF  130
             S   R  A  +++ELL  I  LN +  V GILVQLP+P+ INE  +   +   KDVDGF
Sbjct  69   SSETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPVPEHINERTICNAVDVDKDVDGF  128

Query  131  HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE  190
            +  N+G  +   +   P TP G  RLL+    + L G +AVV+GRS  V  PMA LL  +
Sbjct  129  NEVNIGRTALDMEANIPATPLGVKRLLEHMKIETL-GRNAVVVGRSKNVSLPMAILLHAD  187

Query  191  --------SCTVTVVHSKT--RNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGI  240
                      TVT+ H  T  + + + C+QADI+V AVGK  +I    +K  A VIDVGI
Sbjct  188  GKYATKAMDATVTICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGI  247

Query  241  NRIMTHE--KTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ  293
            NRI      + +LVGDVDFE+   +   ITPVPGGVGPMT+A LM NTL+A R Q
Sbjct  248  NRIKDESTGQFKLVGDVDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARKQ  302


>P18155 NAD-dependent methylenetetrahydrofolate dehydrogenase 
/ Methenyltetrahydrofolate cyclohydrolase [Mus musculus]
Length=350

 Score = 218 bits (555),  Expect = 2e-72
 Identities = 132/292 (45%), Positives = 176/292 (60%), Gaps = 14/292 (5%)

Query  13   IIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGIR  71
            +I G+ +AQ + +EV+ EVE + A G + P L+V+LVG++PAS  YV NK + AA VGI 
Sbjct  39   VISGRKLAQQIKQEVQQEVEEWVASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGIN  98

Query  72   SLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGFH  131
            S      A +SE+ELL  I +LN +  V G+LVQLPLP+ I+E +V   + P KDVDGFH
Sbjct  99   SETIVKPASVSEEELLNSIRKLNNDENVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFH  158

Query  132  SENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE-  190
              NVG +   +  + P TP G   ++K + G    G + VV GRS  VG P+A LL  + 
Sbjct  159  VINVGRMCLDQYSMLPATPWGVWEIIKRT-GIPTLGKNVVVAGRSKNVGMPIAMLLHTDG  217

Query  191  -------SCTVTVVHSKT--RNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGIN  241
                     TVT+ H  T    +++    ADIV++A G  N+I A  +K  A VIDVGIN
Sbjct  218  AHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGIN  277

Query  242  RIM--THEKTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVR  291
            R+      K +LVGDVDFE        ITPVPGGVGPMT+A LMKNT+ A +
Sbjct  278  RVQDPVTAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAK  329



Lambda      K        H        a         alpha
   0.321    0.137    0.390    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1294156


  Database: a3ed98e4ec81d9dcc200d1bf259ceb42.SwissProt.fasta
    Posted date:  May 8, 2024  10:53 PM
  Number of letters in database: 6,096
  Number of sequences in database:  20



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40