BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: bc114296fbfca835bca98e124ed84d59.SwissProt.fasta
20 sequences; 11,100 total letters
Query= ACIAD2572
Length=482
Score E
Sequences producing significant alignments: (Bits) Value
Q8X8Q3 Diguanylate cyclase DgcM [Escherichia coli O157:H7] 89.7 2e-22
P77302 Diguanylate cyclase DgcM [Escherichia coli (strain K12)] 89.4 3e-22
A0A0H3AFM6 Diguanylate cyclase [Vibrio cholerae serotype O1 (stra... 84.0 8e-21
P64826 Uncharacterized protein Mb1389c [Mycobacterium bovis (stra... 80.1 6e-19
P9WM13 Uncharacterized protein Rv1354c [Mycobacterium tuberculosi... 80.1 6e-19
P9WM12 Uncharacterized protein MT1397 [Mycobacterium tuberculosis... 80.1 6e-19
Q8ZNT5 Probable diguanylate cyclase DgcQ [Salmonella typhimurium ... 78.6 2e-18
Q5PLI4 Probable diguanylate cyclase DgcQ [Salmonella paratyphi A ... 78.6 2e-18
Q57N14 Probable diguanylate cyclase DgcQ [Salmonella choleraesuis... 78.6 2e-18
O34311 Signaling protein YkoW [Bacillus subtilis (strain 168)] 78.2 3e-18
Q9HT84 Diguanylate cyclase DgcP [Pseudomonas aeruginosa (strain A... 77.0 6e-18
P55552 Uncharacterized protein y4lL [Sinorhizobium fredii (strain... 77.0 7e-18
A0A0H2ZJS2 Diguanylate cyclase DgcP [Pseudomonas aeruginosa (stra... 76.6 8e-18
Q8Z5R0 Probable diguanylate cyclase DgcQ [Salmonella typhi] 75.9 1e-17
B8GZM2 Diguanylate cyclase [Caulobacter vibrioides (strain NA1000... 75.1 2e-17
Q9A5I5 Diguanylate cyclase [Caulobacter vibrioides (strain ATCC 1... 75.1 2e-17
P77334 Cyclic di-GMP phosphodiesterase PdeR [Escherichia coli (st... 73.9 6e-17
P76237 Probable diguanylate cyclase DgcJ [Escherichia coli (strai... 72.8 1e-16
Q73RG3 Diguanylate cyclase A [Treponema denticola (strain ATCC 35... 71.6 2e-16
P46139 Diguanylate cyclase DgcN [Escherichia coli (strain K12)] 71.2 2e-16
>Q8X8Q3 Diguanylate cyclase DgcM [Escherichia coli O157:H7]
Length=410
Score = 89.7 bits (221), Expect = 2e-22
Identities = 74/257 (29%), Positives = 121/257 (47%), Gaps = 12/257 (5%)
Query 226 ILDVNQATLDLFQAPDKATLLKNTHKI-FAKEMASTFREQLIELWKGNIHHQREAINYAL 284
I+D N A L+ + + K+T +I ++ L G H I+
Sbjct 153 IVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGG--HKPLNFIHKLA 210
Query 285 DGSIRNVLLQFTVFPGYEHNWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNR-SFY 343
DGS R+V Q P + ++ + DIT +K+ E LE+ HD +T L NR FY
Sbjct 211 DGSTRHV--QTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFY 268
Query 344 --TEEINRLERSIVRPVSCIFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYT 401
TE +I + S + +D + K +ND GH GD++L + L ++
Sbjct 269 HITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLV 328
Query 402 ASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSSQP-ISIAIGYATTQHNESI 460
R GG+EFV+L+P T + + +TI +++ S P +++IG A + NESI
Sbjct 329 F-RWGGEEFVLLLPRTPLDTALSLAETIR--VSVAKVSISGLPRFTVSIGVAHHEGNESI 385
Query 461 EDMLKRADQDMYKKKRD 477
+++ KR D +Y+ K D
Sbjct 386 DELFKRVDDALYRAKND 402
>P77302 Diguanylate cyclase DgcM [Escherichia coli (strain K12)]
Length=410
Score = 89.4 bits (220), Expect = 3e-22
Identities = 73/257 (28%), Positives = 121/257 (47%), Gaps = 12/257 (5%)
Query 226 ILDVNQATLDLFQAPDKATLLKNTHKI-FAKEMASTFREQLIELWKGNIHHQREAINYAL 284
I+D N A L+ + + K+T +I ++ L G H ++
Sbjct 153 IVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGG--HKPLNFVHKLA 210
Query 285 DGSIRNVLLQFTVFPGYEHNWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNR-SFY 343
DGS R+V Q P + ++ + DIT +K+ E LE+ HD +T L NR FY
Sbjct 211 DGSTRHV--QTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFY 268
Query 344 --TEEINRLERSIVRPVSCIFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYT 401
TE +I + S + +D + K +ND GH GD++L + L ++
Sbjct 269 HITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLV 328
Query 402 ASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSSQP-ISIAIGYATTQHNESI 460
R GG+EFV+L+P T + + +TI +++ S P +++IG A + NESI
Sbjct 329 F-RWGGEEFVLLLPRTPLDTALSLAETIR--VSVAKVSISGLPRFTVSIGVAHHEGNESI 385
Query 461 EDMLKRADQDMYKKKRD 477
+++ KR D +Y+ K D
Sbjct 386 DELFKRVDDALYRAKND 402
>A0A0H3AFM6 Diguanylate cyclase [Vibrio cholerae serotype O1 (strain
ATCC 39541 / Classical Ogawa 395 / O395)]
Length=321
Score = 84.0 bits (206), Expect = 8e-21
Identities = 72/263 (27%), Positives = 121/263 (46%), Gaps = 19/263 (7%)
Query 227 LDVNQATLDLFQAPDKATLLKNTHKIFAKEMASTFR---EQLIELWKGNIHHQREAINYA 283
L N TL LF+ ++ L K H F + S +Q+ E +H +R A
Sbjct 53 LYANPLTLKLFETNAQSLLGKTDHDFFHDDQLSDILAADQQVFETRLSVVHEER-----A 107
Query 284 LDGSIRNVLLQFTVFPGYEHNWSVVQVAL----TDITARKKAENYLEYLGKHDVLTKLHN 339
+ S V + V H + + L TDIT + L L D LT+L N
Sbjct 108 IAKSNGLVRIYRAVKHPILHRVTGEVIGLIGVSTDITDIVELREQLYQLANTDSLTQLCN 167
Query 340 R----SFYTEEINRLERSIVRPVSCIFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAI 395
R + + R +R + +P+SCI +D++ K +ND GHD GD++L + L Q++
Sbjct 168 RRKLWADFRAAFARAKR-LRQPLSCISIDIDNFKLINDQFGHDKGDEVLCFLAK-LFQSV 225
Query 396 QQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSSQPISIAIGYATTQ 455
+ R+GG+EF+I++ T + + I + F ++ I + G ++
Sbjct 226 ISDHHFCGRVGGEEFIIVLENTHVETAFHLAEQIRQRFAEHPFFEQNEHIYLCAGVSSLH 285
Query 456 HNE-SIEDMLKRADQDMYKKKRD 477
H + I D+ +R+DQ +YK KR+
Sbjct 286 HGDHDIADIYRRSDQALYKAKRN 308
>P64826 Uncharacterized protein Mb1389c [Mycobacterium bovis (strain
ATCC BAA-935 / AF2122/97)]
Length=623
Score = 80.1 bits (196), Expect = 6e-19
Identities = 70/228 (31%), Positives = 108/228 (47%), Gaps = 12/228 (5%)
Query 252 IFAKEMASTFREQLIELWKGNIHHQREAINYALDGSIRNVLLQFTVFPGYEHNWSVVQVA 311
+F E A+ ++LIE +G A+ + G I LL F F + + + +
Sbjct 102 VFRPEPATEDYQRLIEEARGVPVTSAAAVPL-VSGEITTGLLGFIKFGDRKWHEAELNAL 160
Query 312 LT------DITARKKAENYLEYLGKHDVLTKLHNRSFYTEEIN-RLERSIVRPVSCIFLD 364
+T + AR AE L YL HD LT LHNR + ++ RL PV+ +FLD
Sbjct 161 MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLD 220
Query 365 MNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQ 424
++ LK +ND+LGH AGD + + A+ S A R+GGDEFV++ Q
Sbjct 221 LDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIA-RLGGDEFVLIPASPMSADAAQ 279
Query 425 ILQTIYELLNIDNQFYSSQPI--SIAIGYAT-TQHNESIEDMLKRADQ 469
L D+ + + +++IG A+ T + D+L+RADQ
Sbjct 280 PLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQ 327
Score = 19.6 bits (39), Expect = 5.5
Identities = 10/28 (36%), Positives = 16/28 (57%), Gaps = 4/28 (14%)
Query 185 VEDFTRVKMRLDQLRDIG----IDDFRT 208
V+D + L +L+++G IDDF T
Sbjct 488 VQDLHTARATLARLKEVGVHIAIDDFGT 515
>P9WM13 Uncharacterized protein Rv1354c [Mycobacterium tuberculosis
(strain ATCC 25618 / H37Rv)]
Length=623
Score = 80.1 bits (196), Expect = 6e-19
Identities = 70/228 (31%), Positives = 108/228 (47%), Gaps = 12/228 (5%)
Query 252 IFAKEMASTFREQLIELWKGNIHHQREAINYALDGSIRNVLLQFTVFPGYEHNWSVVQVA 311
+F E A+ ++LIE +G A+ + G I LL F F + + + +
Sbjct 102 VFRPEPATEDYQRLIEEARGVPVTSAAAVPL-VSGEITTGLLGFIKFGDRKWHEAELNAL 160
Query 312 LT------DITARKKAENYLEYLGKHDVLTKLHNRSFYTEEIN-RLERSIVRPVSCIFLD 364
+T + AR AE L YL HD LT LHNR + ++ RL PV+ +FLD
Sbjct 161 MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLD 220
Query 365 MNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQ 424
++ LK +ND+LGH AGD + + A+ S A R+GGDEFV++ Q
Sbjct 221 LDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIA-RLGGDEFVLIPASPMSADAAQ 279
Query 425 ILQTIYELLNIDNQFYSSQPI--SIAIGYAT-TQHNESIEDMLKRADQ 469
L D+ + + +++IG A+ T + D+L+RADQ
Sbjct 280 PLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQ 327
Score = 19.6 bits (39), Expect = 5.5
Identities = 10/28 (36%), Positives = 16/28 (57%), Gaps = 4/28 (14%)
Query 185 VEDFTRVKMRLDQLRDIG----IDDFRT 208
V+D + L +L+++G IDDF T
Sbjct 488 VQDLHTARATLARLKEVGVHIAIDDFGT 515
>P9WM12 Uncharacterized protein MT1397 [Mycobacterium tuberculosis
(strain CDC 1551 / Oshkosh)]
Length=623
Score = 80.1 bits (196), Expect = 6e-19
Identities = 70/228 (31%), Positives = 108/228 (47%), Gaps = 12/228 (5%)
Query 252 IFAKEMASTFREQLIELWKGNIHHQREAINYALDGSIRNVLLQFTVFPGYEHNWSVVQVA 311
+F E A+ ++LIE +G A+ + G I LL F F + + + +
Sbjct 102 VFRPEPATEDYQRLIEEARGVPVTSAAAVPL-VSGEITTGLLGFIKFGDRKWHEAELNAL 160
Query 312 LT------DITARKKAENYLEYLGKHDVLTKLHNRSFYTEEIN-RLERSIVRPVSCIFLD 364
+T + AR AE L YL HD LT LHNR + ++ RL PV+ +FLD
Sbjct 161 MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLD 220
Query 365 MNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQ 424
++ LK +ND+LGH AGD + + A+ S A R+GGDEFV++ Q
Sbjct 221 LDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIA-RLGGDEFVLIPASPMSADAAQ 279
Query 425 ILQTIYELLNIDNQFYSSQPI--SIAIGYAT-TQHNESIEDMLKRADQ 469
L D+ + + +++IG A+ T + D+L+RADQ
Sbjct 280 PLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQ 327
Score = 19.6 bits (39), Expect = 5.5
Identities = 10/28 (36%), Positives = 16/28 (57%), Gaps = 4/28 (14%)
Query 185 VEDFTRVKMRLDQLRDIG----IDDFRT 208
V+D + L +L+++G IDDF T
Sbjct 488 VQDLHTARATLARLKEVGVHIAIDDFGT 515
>Q8ZNT5 Probable diguanylate cyclase DgcQ [Salmonella typhimurium
(strain LT2 / SGSC1412 / ATCC 700720)]
Length=570
Score = 78.6 bits (192), Expect = 2e-18
Identities = 53/182 (29%), Positives = 95/182 (52%), Gaps = 14/182 (8%)
Query 304 NWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLE---RSIVRPVSC 360
+W V++ + ++ +N L++ HD LT+L+NR E+ +RL R +P S
Sbjct 376 SWGVIRHMVKNMFV---LQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSV 432
Query 361 IFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEET 420
I LD++ K VND GH AGD +L ++ I+ A R+GG+EF I++PG +
Sbjct 433 IQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHD-IAGRVGGEEFCIVLPGATKA 491
Query 421 AVMQILQTIYELLNIDNQFYSSQP----ISIAIGYATTQH--NESIEDMLKRADQDMYKK 474
+QI + I + +N D + ++ IS ++G ++ + + E + AD+ +Y
Sbjct 492 QALQIAERIRQRIN-DKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYA 550
Query 475 KR 476
K+
Sbjct 551 KQ 552
>Q5PLI4 Probable diguanylate cyclase DgcQ [Salmonella paratyphi
A (strain ATCC 9150 / SARB42)]
Length=570
Score = 78.6 bits (192), Expect = 2e-18
Identities = 53/182 (29%), Positives = 95/182 (52%), Gaps = 14/182 (8%)
Query 304 NWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLE---RSIVRPVSC 360
+W V++ + ++ +N L++ HD LT+L+NR E+ +RL R +P S
Sbjct 376 SWGVIRHIVKNMFV---LQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSV 432
Query 361 IFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEET 420
I LD++ K VND GH AGD +L ++ I+ A R+GG+EF I++PG +
Sbjct 433 IQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHD-IAGRVGGEEFCIVLPGATKA 491
Query 421 AVMQILQTIYELLNIDNQFYSSQP----ISIAIGYATTQH--NESIEDMLKRADQDMYKK 474
+QI + I + +N D + ++ IS ++G ++ + + E + AD+ +Y
Sbjct 492 QALQIAERIRQRIN-DKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYA 550
Query 475 KR 476
K+
Sbjct 551 KQ 552
>Q57N14 Probable diguanylate cyclase DgcQ [Salmonella choleraesuis
(strain SC-B67)]
Length=570
Score = 78.6 bits (192), Expect = 2e-18
Identities = 53/182 (29%), Positives = 95/182 (52%), Gaps = 14/182 (8%)
Query 304 NWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLE---RSIVRPVSC 360
+W V++ + ++ +N L++ HD LT+L+NR E+ +RL R +P S
Sbjct 376 SWGVIRHMVKNMFV---LQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSV 432
Query 361 IFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEET 420
I LD++ K VND GH AGD +L ++ I+ A R+GG+EF I++PG +
Sbjct 433 IQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHD-IAGRVGGEEFCIVLPGATKA 491
Query 421 AVMQILQTIYELLNIDNQFYSSQP----ISIAIGYATTQH--NESIEDMLKRADQDMYKK 474
+QI + I + +N D + ++ IS ++G ++ + + E + AD+ +Y
Sbjct 492 QALQIAERIRQRIN-DKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYA 550
Query 475 KR 476
K+
Sbjct 551 KQ 552
>O34311 Signaling protein YkoW [Bacillus subtilis (strain 168)]
Length=800
Score = 78.2 bits (191), Expect = 3e-18
Identities = 60/179 (34%), Positives = 93/179 (52%), Gaps = 16/179 (9%)
Query 308 VQVALTDITARKKAENYLEYLGKHDVLTKLHNR----SFYTEEINRLERSIVRPVSCIFL 363
+ V D+T + KAE + + +D LT L NR S T+ +NR E S+ FL
Sbjct 351 IYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTKVLNR-EHSLHYNTVVFFL 409
Query 364 DMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILM----PGTEE 419
D+N K +ND LGH+ GD LL+ L+ + + A R+GGDEF+I++ GT E
Sbjct 410 DLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIA-RLGGDEFIIILTDANTGTGE 468
Query 420 TAVM--QILQTIYELLNI-DNQFYSSQPISIAIGYATTQHNESIEDMLKRADQDMYKKK 475
V+ +I+Q + I D+ +S +SI I + + +E ++K+AD MY K
Sbjct 469 ADVLARKIIQKFKKPFKIQDHTLVTS--VSIGIAISPKDGTDGLE-LMKKADMAMYAAK 524
>Q9HT84 Diguanylate cyclase DgcP [Pseudomonas aeruginosa (strain
ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228
/ 1C / PRS 101 / PAO1)]
Length=671
Score = 77.0 bits (188), Expect = 6e-18
Identities = 51/153 (33%), Positives = 83/153 (54%), Gaps = 12/153 (8%)
Query 332 DVLTKLHNRSFYTEEINRLERSIVR------PVSCIFLDMNGLKDVNDHLGHDAGDDLLR 385
D LT L NR+ +E RLE+ + R + LD++ K +ND GH AGD +L+
Sbjct 514 DPLTGLPNRAALSE---RLEQEVARRHRDGGDLLLAVLDIDHFKRINDDFGHLAGDKVLK 570
Query 386 RVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSSQPI 445
+ L + ++Q + A R GG+EFV+L+P T A Q+L+ + + + +P+
Sbjct 571 IIAGELRKRLRQADFIA-RFGGEEFVVLLPATSLEAGRQLLERLRAAIAACPFHFKGEPL 629
Query 446 SI--AIGYATTQHNESIEDMLKRADQDMYKKKR 476
SI + G + NE+ E + +RADQ +Y+ KR
Sbjct 630 SITCSAGITAFEGNEAGEAVFERADQALYRAKR 662
>P55552 Uncharacterized protein y4lL [Sinorhizobium fredii (strain
NBRC 101917 / NGR234)]
Length=827
Score = 77.0 bits (188), Expect = 7e-18
Identities = 55/180 (31%), Positives = 94/180 (52%), Gaps = 14/180 (8%)
Query 308 VQVALTDITARKKAEN-------YLEYLGKHDVLTKLHNRSFYTEEINRLERSIV--RPV 358
V +AL DIT R+ AE + ++ +HD LT L NR F EE RL I +
Sbjct 372 VGIAL-DITERRNAEQERLLAQKQIHHMARHDALTGLPNRQFLREEFERLSDHIAPSTRL 430
Query 359 SCIFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTE 418
+ + LD++G K +ND G GD LLR V L ++Q+ R+ GDEFV+L G
Sbjct 431 AILCLDLDGFKAINDAYGRATGDLLLRHVTERLRNFLKQSDILC-RLSGDEFVVLRVGIN 489
Query 419 ETAVMQIL-QTIYELLNIDNQFYSSQ-PISIAIGY-ATTQHNESIEDMLKRADQDMYKKK 475
A ++L Q + +++ + + + + +G A ++ ++S+++++K AD + + K
Sbjct 490 SNAEARLLAQQLIDVIEAPYELAGTHVDLQVVVGLAAASKSDQSLDELIKTADIALERAK 549
>A0A0H2ZJS2 Diguanylate cyclase DgcP [Pseudomonas aeruginosa (strain
UCBPP-PA14)]
Length=671
Score = 76.6 bits (187), Expect = 8e-18
Identities = 51/153 (33%), Positives = 83/153 (54%), Gaps = 12/153 (8%)
Query 332 DVLTKLHNRSFYTEEINRLERSIVR------PVSCIFLDMNGLKDVNDHLGHDAGDDLLR 385
D LT L NR+ +E RLE+ + R + LD++ K +ND GH AGD +L+
Sbjct 514 DPLTGLPNRAALSE---RLEQEVARRHRDGGDLLLAVLDIDHFKRINDDFGHLAGDKVLK 570
Query 386 RVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSSQPI 445
+ L + ++Q + A R GG+EFV+L+P T A Q+L+ + + + +P+
Sbjct 571 IIAGELRKRLRQADFIA-RFGGEEFVVLLPATSLEAGRQLLERLRAAIAACPFHFKGEPL 629
Query 446 SI--AIGYATTQHNESIEDMLKRADQDMYKKKR 476
SI + G + NE+ E + +RADQ +Y+ KR
Sbjct 630 SITCSAGITAFEGNEAGEVVFERADQALYRAKR 662
>Q8Z5R0 Probable diguanylate cyclase DgcQ [Salmonella typhi]
Length=567
Score = 75.9 bits (185), Expect = 1e-17
Identities = 52/182 (29%), Positives = 94/182 (52%), Gaps = 14/182 (8%)
Query 304 NWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLE---RSIVRPVSC 360
+W V++ + ++ +N ++ HD LT+L+NR E+ +RL R +P S
Sbjct 373 SWGVIRHMVKNMFV---LQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSV 429
Query 361 IFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEET 420
I LD++ K VND GH AGD +L ++ I+ A R+GG+EF I++PG +
Sbjct 430 IQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHD-IAGRVGGEEFCIVLPGATKA 488
Query 421 AVMQILQTIYELLNIDNQFYSSQP----ISIAIGYATTQH--NESIEDMLKRADQDMYKK 474
+QI + I + +N D + ++ IS ++G ++ + + E + AD+ +Y
Sbjct 489 QALQIAERIRQRIN-DKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYA 547
Query 475 KR 476
K+
Sbjct 548 KQ 549
>B8GZM2 Diguanylate cyclase [Caulobacter vibrioides (strain NA1000
/ CB15N)]
Length=454
Score = 75.1 bits (183), Expect = 2e-17
Identities = 53/173 (31%), Positives = 83/173 (48%), Gaps = 24/173 (14%)
Query 318 RKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLERSIVR---PVSCIFLDMNGLKDVNDH 374
R ++ LE L D LT LHNR + T +++ L + PVS + +D++ K +ND
Sbjct 279 RNNLDHSLE-LAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDT 337
Query 375 LGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLN 434
GHD GD++LR L ++ R GG+EFV++MP T ++I + I
Sbjct 338 FGHDIGDEVLREFALRLASNVRAIDLPC-RYGGEEFVVIMPDTALADALRIAERI----- 391
Query 435 IDNQFYSSQPISIAIG------------YATTQHNESIEDMLKRADQDMYKKK 475
S P ++A G AT ++ E +LKRAD+ +Y+ K
Sbjct 392 --RMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAK 442
>Q9A5I5 Diguanylate cyclase [Caulobacter vibrioides (strain ATCC
19089 / CB15)]
Length=454
Score = 75.1 bits (183), Expect = 2e-17
Identities = 53/173 (31%), Positives = 83/173 (48%), Gaps = 24/173 (14%)
Query 318 RKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLERSIVR---PVSCIFLDMNGLKDVNDH 374
R ++ LE L D LT LHNR + T +++ L + PVS + +D++ K +ND
Sbjct 279 RNNLDHSLE-LAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDT 337
Query 375 LGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLN 434
GHD GD++LR L ++ R GG+EFV++MP T ++I + I
Sbjct 338 FGHDIGDEVLREFALRLASNVRAIDLPC-RYGGEEFVVIMPDTALADALRIAERI----- 391
Query 435 IDNQFYSSQPISIAIG------------YATTQHNESIEDMLKRADQDMYKKK 475
S P ++A G AT ++ E +LKRAD+ +Y+ K
Sbjct 392 --RMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAK 442
>P77334 Cyclic di-GMP phosphodiesterase PdeR [Escherichia coli
(strain K12)]
Length=661
Score = 73.9 bits (180), Expect = 6e-17
Identities = 65/256 (25%), Positives = 114/256 (45%), Gaps = 31/256 (12%)
Query 229 VNQATLDLFQAPDKATLLKNTHKIFAKEMASTFREQLIELWKGNIHHQREAI---NYALD 285
+ Q+ LF + +A + +++F + + + +ELW QR + +
Sbjct 152 IGQSVFKLFMSRREAAASRRNNRVFFRS-GNAYE---VELWIPTCKGQRLFLFRNKFVHS 207
Query 286 GSIRNVLLQFTVFPGYEHNWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTE 345
GS +N + F + G TDIT ++A+ L L D +T L NR+ +
Sbjct 208 GSGKNEI--FLICSG------------TDITEERRAQERLRILANTDSITGLPNRNAMQD 253
Query 346 EINR-LERSIVRPVSCIFLDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASR 404
I+ + + V ++LD++ K VND GH GD LLR V + ++ A R
Sbjct 254 LIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLA-R 312
Query 405 IGGDEFVILMPGTEETAVMQILQTIYELLNID-----NQFYSSQPISIAIGYATTQHNES 459
GGDEF++L T ++A+ + I L + + Y+S + IA+ + +H
Sbjct 313 PGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIAL---SPEHGSD 369
Query 460 IEDMLKRADQDMYKKK 475
+++ AD MY K
Sbjct 370 STAIIRHADTAMYTAK 385
Score = 20.4 bits (41), Expect = 3.2
Identities = 10/42 (24%), Positives = 19/42 (45%), Gaps = 0/42 (0%)
Query 428 TIYELLNIDNQFYSSQPISIAIGYATTQHNESIEDMLKRADQ 469
T+Y L N ++ S + ++TT+ E + A+Q
Sbjct 9 TLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQ 50
>P76237 Probable diguanylate cyclase DgcJ [Escherichia coli (strain
K12)]
Length=496
Score = 72.8 bits (177), Expect = 1e-16
Identities = 65/275 (24%), Positives = 126/275 (46%), Gaps = 19/275 (7%)
Query 214 PEFVNQCVEDILILDVNQATL-DLFQAPDKATLLKNTHKIFAKEMASTFREQLIELWKGN 272
P +V ++ I++LD+N+ L ++F D+ L + + + R+ +I + N
Sbjct 225 PVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTD--TDSGRDIIINQSEDN 282
Query 273 IHHQREAINYALDGSIRNVLLQFTVFPGYEHNWSVVQ-------VALTDITARKKAENYL 325
+ Q + + L G IR V L + +W V + L + + +
Sbjct 283 LF-QYVSYVHDLPGGIR-VSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNV 340
Query 326 EYLGKHDVLTKLHNRSFYTEEINRLERSIVRPVSCIF---LDMNGLKDVNDHLGHDAGDD 382
D +T L+NR T E+ + + +V+ S + +DM+ LK +ND LGH GD
Sbjct 341 SRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDL 400
Query 383 LLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAVMQILQTIYELLNIDNQFYSS 442
+ + + Q+I+++ Y A R+GGDEF I++ + Q+ + I + L
Sbjct 401 AITLLAQAIKQSIRKSDY-AIRLGGDEFCIILVDSTPQIAAQLPERIEKRL---QHIAPQ 456
Query 443 QPISIAIGYATTQHNESIEDMLKRADQDMYKKKRD 477
+ I + G + N+++ D K +D+ +Y K++
Sbjct 457 KEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQN 491
>Q73RG3 Diguanylate cyclase A [Treponema denticola (strain ATCC
35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)]
Length=371
Score = 71.6 bits (174), Expect = 2e-16
Identities = 46/178 (26%), Positives = 91/178 (51%), Gaps = 16/178 (9%)
Query 303 HNWSVVQVALTDITARKKAENYLEYLGKHDVLTKLHNRSFYTEEINRLERSIVRPVSCIF 362
+N ++++ TDI K ++Y L + T N S +E +S +
Sbjct 192 NNSQLLEMTTTDIMTHLKLKHYFFTLLMEHLYTI--NSSGEKKET----------LSILM 239
Query 363 LDMNGLKDVNDHLGHDAGDDLLRRVGHILTQAIQQTSYTASRIGGDEFVILMPGTEETAV 422
+D++ K++ND GH AGD +L V I+ + TA+R GG+EF++++ T +A
Sbjct 240 IDIDFFKNINDTYGHAAGDIVLEEVAKIIKSCTRNAD-TAARYGGEEFIVMLNNTSASAA 298
Query 423 MQILQTIYELLNIDNQFYSSQPISIAIGYATTQHN---ESIEDMLKRADQDMYKKKRD 477
M + + I + + + Y + I++ I + +N ES + +++RAD+ +Y+ K++
Sbjct 299 MAVAERIRKSVEEKSIMYDGKKINVTISIGVSSYNFDLESAKSIVERADKALYESKQN 356
>P46139 Diguanylate cyclase DgcN [Escherichia coli (strain K12)]
Length=408
Score = 71.2 bits (173), Expect = 2e-16
Identities = 49/150 (33%), Positives = 79/150 (53%), Gaps = 6/150 (4%)
Query 331 HDVLTKLHNRSFYTEEINRL-ERSIVRPVSCI-FLDMNGLKDVNDHLGHDAGDDLLRRVG 388
HD LT L NR+ + IN L S R S + FLD + K +ND GH GD +L +
Sbjct 251 HDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIA 310
Query 389 HILTQAIQQTSYTASRIGGDEFVILMPGTE-ETAVMQILQTIYELLNIDNQFYSSQP--I 445
L + + A R+GGDEF +++ + E+ V QI + ++ N+ ++ +
Sbjct 311 KRLAE-FGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTM 369
Query 446 SIAIGYATTQHNESIEDMLKRADQDMYKKK 475
+++IGYA T + S E + + AD +MY+ K
Sbjct 370 TLSIGYAMTIEHASAEKLQELADHNMYQAK 399
Score = 21.2 bits (43), Expect = 1.7
Identities = 9/19 (47%), Positives = 12/19 (63%), Gaps = 0/19 (0%)
Query 75 DLFEASSQQELCSQLHQIF 93
D+ S Q++CS L QIF
Sbjct 337 DVQSESEVQQICSALTQIF 355
Lambda K H a alpha
0.322 0.137 0.400 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 4270000
Database: bc114296fbfca835bca98e124ed84d59.SwissProt.fasta
Posted date: May 20, 2024 2:45 AM
Number of letters in database: 11,100
Number of sequences in database: 20
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
