Comparative Genomics

ACIAD2920 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 039cfcfd897ee21500f4aae291ade56f.SwissProt.fasta
           17 sequences; 2,586 total letters



Query= ACIAD2920

Length=147
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q8ZCA8 HTH-type transcriptional regulator CueR [Yersinia pestis]      58.9    2e-15
Q8FK74 HTH-type transcriptional regulator CueR [Escherichia coli ...  58.5    2e-15
Q8XD09 HTH-type transcriptional regulator CueR [Escherichia coli ...  57.8    4e-15
P0A9G5 HTH-type transcriptional regulator CueR [Shigella flexneri]    57.4    5e-15
P0A9G4 HTH-type transcriptional regulator CueR [Escherichia coli ...  57.4    5e-15
Q8Z8S3 HTH-type transcriptional regulator CueR [Salmonella typhi]     57.0    8e-15
Q93CH6 HTH-type transcriptional regulator CueR [Salmonella typhim...  57.0    8e-15
Q9ZHI4 HTH-type transcriptional activator SoxR homolog [Chromobac...  52.4    5e-13
P0ACS6 HTH-type transcriptional regulator ZntR [Escherichia coli ...  50.4    3e-12
P0ACS5 HTH-type transcriptional regulator ZntR [Escherichia coli ...  50.4    3e-12
Q55963 Uncharacterized HTH-type transcriptional regulator slr0701...  48.1    2e-11
P22896 Mercuric resistance operon regulatory protein [Acidithioba...  47.4    3e-11
Q51506 Redox-sensitive transcriptional activator SoxR [Pseudomona...  45.4    2e-10
P39842 Multidrug-efflux transporter 2 regulator [Bacillus subtili...  42.0    8e-09
P50329 Nodulation protein NolA [Bradyrhizobium elkanii]               39.3    6e-08
O06474 HTH-type transcriptional regulator YfmP [Bacillus subtilis...  38.5    6e-08


>Q8ZCA8 HTH-type transcriptional regulator CueR [Yersinia pestis]
Length=139

 Score = 58.9 bits (141),  Expect = 2e-15
 Identities = 37/121 (31%), Positives = 67/121 (55%), Gaps = 7/121 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A++TGL S AIR+YE++KL+  P+      R ++ + I++L L+  A+Q GF++
Sbjct  1    MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRTDNGYRSYTAKHIEELTLLRQARQVGFTL  60

Query  63   QEIRSMLEKPQSPID-----KNQLKQKALQIEEKIVEMKVLSKTLRHVA-QCSFDNPLNC  116
             E R +L    +P       K     K  +IE+ I ++  +   L  +A +C  D   +C
Sbjct  61   DECRELLALFHNPARHSADVKAATLLKVAEIEQHINDLNQMRMRLLALAEECPGDEGADC  120

Query  117  P  117
            P
Sbjct  121  P  121


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 10/14 (71%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           ++E+T+   ARQ G
Sbjct  44  IEELTLLRQARQVG  57


>Q8FK74 HTH-type transcriptional regulator CueR [Escherichia coli 
O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=135

 Score = 58.5 bits (140),  Expect = 2e-15
 Identities = 38/126 (30%), Positives = 73/126 (58%), Gaps = 7/126 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLIHPIGR-KGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A+ TGL S AIR+YE++ L+ P  R +   R ++ Q +++L L+  A+Q GF++
Sbjct  1    MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNL  60

Query  63   Q---EIRSMLEKPQ--SPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +   E+ ++   PQ  S   K +  +K  +IE+ I E++ +   L  +A  C  D+  +C
Sbjct  61   EESGELVNLFNDPQRHSADVKRRTLEKVAEIEQHIEELQSMRNQLLALANACPGDDSADC  120

Query  117  PKFQKI  122
            P  + +
Sbjct  121  PIIENL  126


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>Q8XD09 HTH-type transcriptional regulator CueR [Escherichia coli 
O157:H7]
Length=135

 Score = 57.8 bits (138),  Expect = 4e-15
 Identities = 38/126 (30%), Positives = 72/126 (57%), Gaps = 7/126 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLIHPIGR-KGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A+ TGL S AIR+YE++ L+ P  R +   R ++ Q +++L L+  A+Q GF++
Sbjct  1    MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNL  60

Query  63   Q---EIRSMLEKPQ--SPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +   E+ ++   PQ  S   K +  +K  +IE  I E++ +   L  +A  C  D+  +C
Sbjct  61   EESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRNQLLALANACPGDDSADC  120

Query  117  PKFQKI  122
            P  + +
Sbjct  121  PIIENL  126


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>P0A9G5 HTH-type transcriptional regulator CueR [Shigella flexneri]
Length=135

 Score = 57.4 bits (137),  Expect = 5e-15
 Identities = 38/126 (30%), Positives = 72/126 (57%), Gaps = 7/126 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLIHPIGR-KGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A+ TGL S AIR+YE++ L+ P  R +   R ++ Q +++L L+  A+Q GF++
Sbjct  1    MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNL  60

Query  63   Q---EIRSMLEKPQ--SPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +   E+ ++   PQ  S   K +  +K  +IE  I E++ +   L  +A  C  D+  +C
Sbjct  61   EESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADC  120

Query  117  PKFQKI  122
            P  + +
Sbjct  121  PIIENL  126


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>P0A9G4 HTH-type transcriptional regulator CueR [Escherichia coli 
(strain K12)]
Length=135

 Score = 57.4 bits (137),  Expect = 5e-15
 Identities = 38/126 (30%), Positives = 72/126 (57%), Gaps = 7/126 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLIHPIGR-KGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A+ TGL S AIR+YE++ L+ P  R +   R ++ Q +++L L+  A+Q GF++
Sbjct  1    MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNL  60

Query  63   Q---EIRSMLEKPQ--SPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +   E+ ++   PQ  S   K +  +K  +IE  I E++ +   L  +A  C  D+  +C
Sbjct  61   EESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADC  120

Query  117  PKFQKI  122
            P  + +
Sbjct  121  PIIENL  126


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>Q8Z8S3 HTH-type transcriptional regulator CueR [Salmonella typhi]
Length=138

 Score = 57.0 bits (136),  Expect = 8e-15
 Identities = 34/121 (28%), Positives = 70/121 (58%), Gaps = 7/121 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A++TGL S AIR+YE++ L+  P+  +   R ++ + +++L L+  A+Q GF++
Sbjct  1    MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYTQKHLNELTLLRQARQVGFNL  60

Query  63   QEIRSMLE-----KPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +E   ++      +  S   K +  +K  +IE  I E++ +   L  +A+ C  D+  +C
Sbjct  61   EECGELVNLFNDPRRHSADVKKRTLEKVAEIERHISELQSMRDQLLAMAESCPGDDSADC  120

Query  117  P  117
            P
Sbjct  121  P  121


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>Q93CH6 HTH-type transcriptional regulator CueR [Salmonella typhimurium 
(strain LT2 / SGSC1412 / ATCC 700720)]
Length=138

 Score = 57.0 bits (136),  Expect = 8e-15
 Identities = 34/121 (28%), Positives = 70/121 (58%), Gaps = 7/121 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            + +S++A++TGL S AIR+YE++ L+  P+  +   R ++ + +++L L+  A+Q GF++
Sbjct  1    MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYTQKHLNELTLLRQARQVGFNL  60

Query  63   QEIRSMLE-----KPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLRHVAQ-CSFDNPLNC  116
            +E   ++      +  S   K +  +K  +IE  I E++ +   L  +A+ C  D+  +C
Sbjct  61   EECGELVNLFNDPRRHSADVKKRTLEKVAEIERHISELQSMRDQLLALAESCPGDDSADC  120

Query  117  P  117
            P
Sbjct  121  P  121


 Score = 16.9 bits (32),  Expect = 1.8
 Identities = 6/14 (43%), Positives = 9/14 (64%), Gaps = 0/14 (0%)

Query  1   MKEITMSELARQTG  14
           + E+T+   ARQ G
Sbjct  44  LNELTLLRQARQVG  57


>Q9ZHI4 HTH-type transcriptional activator SoxR homolog [Chromobacterium 
violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 
/ NBRC 12614 / NCIMB 9131 / NCTC 9757)]
Length=148

 Score = 52.4 bits (124),  Expect = 5e-13
 Identities = 25/66 (38%), Positives = 42/66 (64%), Gaps = 0/66 (0%)

Query  4   ITMSELARQTGLKSSAIRYYEKEKLIHPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSIQ  63
           IT+  LA++TG+ +SA+R+YE   LIH +G  G  R +    I +++ I +A+  G S+Q
Sbjct  6   ITIGRLAKRTGVAASALRFYEARGLIHSVGEAGKTRRYRRDAIRRVSFIRVAQAMGMSLQ  65

Query  64  EIRSML  69
           +I + L
Sbjct  66  DIGAAL  71


>P0ACS6 HTH-type transcriptional regulator ZntR [Escherichia coli 
O157:H7]
Length=141

 Score = 50.4 bits (119),  Expect = 3e-12
 Identities = 28/107 (26%), Positives = 60/107 (56%), Gaps = 7/107 (7%)

Query  6    MSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSIQE  64
            + ELA+   +    IRYYEK++++ H +  +G  R+++   + +L  I  A+Q GFS++ 
Sbjct  4    IGELAKMAEVTPDTIRYYEKQQMMEHEVRTEGGFRLYTESDLQRLKFIRHARQLGFSLES  63

Query  65   IRSML------EKPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLRHV  105
            IR +L      E       K  ++++  ++E +I E++ + ++L+ +
Sbjct  64   IRELLSIRIDPEHHTCQESKGIVQERLQEVEARIAELQSMQRSLQRL  110


>P0ACS5 HTH-type transcriptional regulator ZntR [Escherichia coli 
(strain K12)]
Length=141

 Score = 50.4 bits (119),  Expect = 3e-12
 Identities = 28/107 (26%), Positives = 60/107 (56%), Gaps = 7/107 (7%)

Query  6    MSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSIQE  64
            + ELA+   +    IRYYEK++++ H +  +G  R+++   + +L  I  A+Q GFS++ 
Sbjct  4    IGELAKMAEVTPDTIRYYEKQQMMEHEVRTEGGFRLYTESDLQRLKFIRHARQLGFSLES  63

Query  65   IRSML------EKPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLRHV  105
            IR +L      E       K  ++++  ++E +I E++ + ++L+ +
Sbjct  64   IRELLSIRIDPEHHTCQESKGIVQERLQEVEARIAELQSMQRSLQRL  110


>Q55963 Uncharacterized HTH-type transcriptional regulator slr0701 
[Synechocystis sp. (strain PCC 6803 / Kazusa)]
Length=137

 Score = 48.1 bits (113),  Expect = 2e-11
 Identities = 35/108 (32%), Positives = 60/108 (56%), Gaps = 6/108 (6%)

Query  4    ITMSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQAGFSI  62
            +T+SE+AR+ GL    + +YE+  ++ HP   +   RV+  + +  L+ I  AK  GFS+
Sbjct  5    LTVSEVARKLGLNPQTLYFYERIGVVDHPQRNQSGYRVYQEKDLAILSFIRHAKDLGFSL  64

Query  63   QEIRSM--LEKPQS-PIDK--NQLKQKALQIEEKIVEMKVLSKTLRHV  105
            +EI  +  L+  QS   D+  ++L  K LQ+E  I EM+ +   L  +
Sbjct  65   EEIADILHLQSQQSLTCDEIYHKLTSKILQLESGIKEMEKMKDDLSKI  112


>P22896 Mercuric resistance operon regulatory protein [Acidithiobacillus 
ferrooxidans]
Length=122

 Score = 47.4 bits (111),  Expect = 3e-11
 Identities = 28/109 (26%), Positives = 57/109 (52%), Gaps = 6/109 (6%)

Query  5    TMSELARQTGLKSSAIRYYEKEKLIHPIGRKGL-QRVFSIQIIDQLALIHLAKQAGFSIQ  63
            T+ ++A   G+ +  +RYYEKE LI P  R     R+++ + + ++  I  A+  GFS+ 
Sbjct  7    TIGKVATLAGVSTDTLRYYEKEHLIEPASRTAAGYRLYNDEAVRRIRFIKTAQHCGFSLS  66

Query  64   EIRSMLEKPQSPID-----KNQLKQKALQIEEKIVEMKVLSKTLRHVAQ  107
            +I+ +L   ++        ++   +K L+I  K+  ++ +S  L  + Q
Sbjct  67   DIQELLTLKRTDSACCEDVRSVAIEKRLRIARKLRVLQAMSAALNDLIQ  115


>Q51506 Redox-sensitive transcriptional activator SoxR [Pseudomonas 
aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 
/ JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)]
Length=156

 Score = 45.4 bits (106),  Expect = 2e-10
 Identities = 23/69 (33%), Positives = 42/69 (61%), Gaps = 0/69 (0%)

Query  2   KEITMSELARQTGLKSSAIRYYEKEKLIHPIGRKGLQRVFSIQIIDQLALIHLAKQAGFS  61
           +E+++ ELAR+ G+  SA+ +YE + LI      G QR FS + + ++ +I +A++ G  
Sbjct  8   RELSVGELARRAGVAVSALHFYETKGLISSQRNAGNQRRFSRETLRRVVVIKVAQRVGIP  67

Query  62  IQEIRSMLE  70
           + EI   L+
Sbjct  68  LAEIARALQ  76


>P39842 Multidrug-efflux transporter 2 regulator [Bacillus subtilis 
(strain 168)]
Length=273

 Score = 42.0 bits (97),  Expect = 8e-09
 Identities = 26/103 (25%), Positives = 54/103 (52%), Gaps = 1/103 (1%)

Query  2    KEITMSELARQTGLKSSAIRYYEKEKLIHP-IGRKGLQRVFSIQIIDQLALIHLAKQAGF  60
            K  T  E ++   +K   + +Y++  L  P I ++   R +S    +   +I L K+ G 
Sbjct  7    KYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGYRYYSYHQFETFQVISLFKELGV  66

Query  61   SIQEIRSMLEKPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLR  103
             ++EI+ +++        + LK+K+++I++KI E+K L   L+
Sbjct  67   PLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELKQLQTILQ  109


>P50329 Nodulation protein NolA [Bradyrhizobium elkanii]
Length=219

 Score = 39.3 bits (90),  Expect = 6e-08
 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 3/99 (3%)

Query  6    MSELARQTGLKSSAIRYYEKEKLIHPIGRK-GLQRVFSIQIIDQLALIHLAKQAGFSIQE  64
            + ELA  TG+    + +YE   L+    R  G  R++  + + ++  I   ++ GFS+ E
Sbjct  13   IGELAEATGVTVRTLHHYEHTGLLAASERTDGGHRMYDRESVQRVHQIRALRELGFSLHE  72

Query  65   IRSMLEKPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLR  103
            IR  +E   S ID   L++   +IE ++    +L   LR
Sbjct  73   IRKAMEGTTSLID--LLRKHLERIELQVARATLLRDRLR  109


>O06474 HTH-type transcriptional regulator YfmP [Bacillus subtilis 
(strain 168)]
Length=140

 Score = 38.5 bits (88),  Expect = 6e-08
 Identities = 27/106 (25%), Positives = 58/106 (55%), Gaps = 2/106 (2%)

Query  1    MKEITMSELARQTGLKSSAIRYYEKEKLI-HPIGRKGLQRVFSIQIIDQLALIHLAKQA-  58
            M+ + + ++A+++GL    IR+YE+  LI  P    G  R++S   +++L  +   K+  
Sbjct  1    MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSEDDMEELEKVISTKEVL  60

Query  59   GFSIQEIRSMLEKPQSPIDKNQLKQKALQIEEKIVEMKVLSKTLRH  104
            GFS+QE++  +E  +      +    +L  +E+  +++ + +TL H
Sbjct  61   GFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQETLNH  106



Lambda      K        H        a         alpha
   0.322    0.135    0.374    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 226904


  Database: 039cfcfd897ee21500f4aae291ade56f.SwissProt.fasta
    Posted date:  May 20, 2024  8:45 AM
  Number of letters in database: 2,586
  Number of sequences in database:  17



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40