BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 2d729be6bb37d70ec25235d3835202fa.SwissProt.fasta
21 sequences; 15,223 total letters
Query= ACIAD2989
Length=712
Score E
Sequences producing significant alignments: (Bits) Value
Q8XCP2 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 413 2e-137
B5YXY4 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 410 2e-136
Q8FFG4 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 410 3e-136
B7N5V2 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 409 4e-136
Q1R972 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 409 5e-136
A1ADI8 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 409 5e-136
B7MY16 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 409 7e-136
B7UFZ8 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 408 1e-135
B7NP24 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 408 1e-135
B1IXA5 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 407 2e-135
B7MGV7 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 407 3e-135
P77399 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hyd... 405 2e-134
Q9AHY3 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA ... 358 1e-116
Q93Q12 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA ... 358 2e-116
P21177 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA ... 354 1e-114
P28793 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA ... 352 4e-114
Q9F0Y7 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA ... 350 4e-113
Q8BMS1 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-... 341 2e-109
P40939 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-... 337 5e-108
Q64428 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-... 337 7e-108
Q29554 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-... 335 5e-107
>Q8XCP2 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O157:H7]
Length=714
Score = 413 bits (1061), Expect = 2e-137
Identities = 260/710 (37%), Positives = 386/710 (54%), Gaps = 26/710 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEALARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + AQ+ +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKKDRPSSRPLPVRERILAGPLGR----AQLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K GIPV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGIPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG A I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVAHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKE 702
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVE 697
>B5YXY4 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O157:H7 (strain
EC4115 / EHEC)]
Length=714
Score = 410 bits (1054), Expect = 2e-136
Identities = 259/710 (36%), Positives = 385/710 (54%), Gaps = 26/710 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEALARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKKDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K GIPV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGIPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG A I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVAHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKE 702
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVE 697
>Q8FFG4 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O6:H1 (strain
CFT073 / ATCC 700928 / UPEC)]
Length=714
Score = 410 bits (1053), Expect = 3e-136
Identities = 257/714 (36%), Positives = 387/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI ++T+D G+ NT+ AEF + + ++L+ DL+G++F SAK
Sbjct 5 SAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKDLRGVVFISAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L VPV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIANCKTAQEAEALARQGQQLMAE---IHALPVPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA + I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EQKTQGNYPATKRILDVIETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIADIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMSKR 701
>B7N5V2 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O17:K52:H18
(strain UMN026 / ExPEC)]
Length=714
Score = 409 bits (1052), Expect = 4e-136
Identities = 258/714 (36%), Positives = 387/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI ++T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L VPV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEALARQGQQLMAE---IHALPVPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRMCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D Q LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVP-QSILLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDRQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGTQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMSKR 701
>Q1R972 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli (strain UTI89
/ UPEC)]
Length=714
Score = 409 bits (1051), Expect = 5e-136
Identities = 256/714 (36%), Positives = 386/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++++ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQIRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+ +
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTDVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIMPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSER 701
>A1ADI8 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O1:K1 / APEC]
Length=714
Score = 409 bits (1051), Expect = 5e-136
Identities = 256/714 (36%), Positives = 386/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++++ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQIRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+ +
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTDVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIMPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSER 701
>B7MY16 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O81 (strain
ED1a)]
Length=714
Score = 409 bits (1050), Expect = 7e-136
Identities = 257/714 (36%), Positives = 385/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSER 701
>B7UFZ8 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O127:H6 (strain
E2348/69 / EPEC)]
Length=714
Score = 408 bits (1049), Expect = 1e-135
Identities = 256/714 (36%), Positives = 385/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++++ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQIRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASSEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIMPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSER 701
>B7NP24 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O7:K1 (strain
IAI39 / ExPEC)]
Length=714
Score = 408 bits (1048), Expect = 1e-135
Identities = 258/714 (36%), Positives = 385/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFISAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L VPV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPVPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +D K+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDAKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D Q LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVP-QSILLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTEVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMSKR 701
>B1IXA5 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli (strain ATCC
8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)]
Length=714
Score = 407 bits (1047), Expect = 2e-135
Identities = 257/714 (36%), Positives = 388/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D + NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPDEKMNTLKAEFASQVRAIIKQLRENKELRGVVFISAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEALARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ VK + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELVKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+ +
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTDVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMSKR 701
>B7MGV7 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli O45:K1 (strain
S88 / ExPEC)]
Length=714
Score = 407 bits (1046), Expect = 3e-135
Identities = 256/714 (36%), Positives = 385/714 (54%), Gaps = 26/714 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI I+T+D G+ NT+ AEF + + ++++ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQIRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQPEHATEFF-KMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + E + ++L A+ I L +PV+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEVLARQGQQLMAE---IHALPIPVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQAVK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K + S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKQDRPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+ +
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRNIFFASTDVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K G+PV +KD++ YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPRGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYCGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CATHTIFASNTSSLPIGDIAAHAARPEQVIGLHFFSPVEKMPLVEIIPHASTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L EG I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERIEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIMPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G K Q L Q +S ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGCKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCLDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQ 706
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E +++
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCDRLVEMSER 701
>P77399 Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli (strain K12)]
Length=714
Score = 405 bits (1040), Expect = 2e-134
Identities = 256/710 (36%), Positives = 383/710 (54%), Gaps = 26/710 (4%)
Query 2 SAIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-T 60
SA DNI ++T+D G+ NT+ AEF + + ++L+ +L+G++F SAK
Sbjct 5 SAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDN 64
Query 61 FFAGGDLDELIQVQP-EHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELAL 119
F AG D++ + + + A + ++L A+ I L + V+AA++G LGGG ELAL
Sbjct 65 FIAGADINMIGNCKTAQEAEALARQGQQLMAE---IHALPIQVIAAIHGACLGGGLELAL 121
Query 120 GCHYRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKS 179
CH R+ +DPK+ GLPEV LGLLPG GG R+ RL+G+ A ++ GKQ QA
Sbjct 122 ACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALK 181
Query 180 LGLVHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAML 239
LGLV D + LL+ A+ K S +P V+ + G + A + +
Sbjct 182 LGLVDDVVPHSI-LLEAAVELAKKERPSSRPLPVRERILAGPLGR----ALLFKMVGKKT 236
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
KT+G YPA E I+ G + E+R F +LA+ ++ + F+ +
Sbjct 237 EHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTDVK 296
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIK-GIPVILKDVSVENAEKGKAYSQ 358
K S D VG+LG G+MG GIAY TA K GIPV +KD++ + YS
Sbjct 297 KDPGS---DAPPAPLNSVGILGGGLMGGGIAYVTACKAGIPVRIKDINPQGINHALKYSW 353
Query 359 KLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQY 418
L+ +V + + A +R++ LALI+ T D DLIIEAVFEN ELK ++ E EQ
Sbjct 354 DQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQN 413
Query 419 LAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKA 478
A IFASNTS+LPI +A + + IGLHFFSPV+KM LVEII TSA+T+A
Sbjct 414 CAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATT 473
Query 479 YDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPL 538
++ KTPIVV D GF+ +R+ +I E +R+L +G I+ A +K G PVGP+
Sbjct 474 VKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTQGERVEHIDAALVKFGFPVGPI 533
Query 539 AIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYP 598
+ DEV + ++ L+A + P + VV +++++ +RKG+ G GFY Y
Sbjct 534 QLLDEVGI----DTGTKIIPVLEAAYGERFSAPAN-VVSSILND-DRKGRKNGRGFYLYG 587
Query 599 EHGKKHLWQ------GLDRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANV 652
+ G+K Q L Q IS ++ +R + + + +RC +E V+ SV D ++
Sbjct 588 QKGRKSKKQVDPAIYPLIGTQGQGRISAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDI 647
Query 653 GSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKE 702
G++FGIGF P+ GG ++++ G + + LA +YG RF P L E
Sbjct 648 GAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVE 697
>Q9AHY3 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
isomerase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Pseudomonas putida]
Length=715
Score = 358 bits (920), Expect = 1e-116
Identities = 234/718 (33%), Positives = 370/718 (52%), Gaps = 25/718 (3%)
Query 3 AIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKKTFF 62
AI + IV L D G+S N N + L +KA+ +KG+I S K F
Sbjct 7 AITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSSGKDVFI 66
Query 63 AGGDLDELIQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCH 122
G D+ E + E + E L VP VAA+NG ALGGG E+ L
Sbjct 67 VGADITEFVDNFKLPEAELVAGNLEANRIFSAFEDLEVPTVAAINGIALGGGLEMCLAAD 126
Query 123 YRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGL 182
YR+ +K GLPEV LG+ PG GG VR+ RL+G NA ++ GK+ + A +G
Sbjct 127 YRVM--STSAKIGLPEVKLGIYPGFGGTVRLPRLIGSDNAVEWIASGKENRAEDALKVGA 184
Query 183 VHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDP-KTPAVAQVLAI--APAML 239
V D + L A+ +K + D K + P + K A+ Q++A A +
Sbjct 185 V-DAVVAPELLQAGALDLIKRAISGE--LDYKAKRQPKLEKLKLNAIEQMMAFETAKGFV 241
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
+ YPAP + + A D AL +E+ F +LA +A+++IG F + +
Sbjct 242 AGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFAKLAKTSVAESLIGLFLND-QEL 300
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGKAYSQK 359
K A ++A + VLGAG+MG GIAY +A+KG P+++KD+ E + G + K
Sbjct 301 KRKAKAHDEIAH-DVKQAAVLGAGIMGGGIAYQSAVKGTPILMKDIREEAIQLGLNEASK 359
Query 360 LLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQYL 419
LL RV +GR+T K + L I T D D+++EAV EN ++K V E E +
Sbjct 360 LLGNRVDKGRLTPAKMAEALNAIRPTLSYGDFANVDIVVEAVVENPKVKQAVLAEVEGQV 419
Query 420 AEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKAY 479
E I ASNTST+ I LA A K +NF+G+HFF+PV M LVE+I+G+++S +A
Sbjct 420 KEDAILASNTSTISINLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSEVAVATTV 479
Query 480 DFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPLA 539
+ +++ K PIVVND GF +RV + +L++ GV +I+ K G P+GP
Sbjct 480 AYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAY 539
Query 540 IQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEY-- 597
+ D V + H + KD ++ VD ++E NR G+ G GFY Y
Sbjct 540 LMDVVGIDTGHHGRDVMAEGFPDRMKDERRSAVD-----ALYEANRLGQKNGKGFYAYET 594
Query 598 PEHGK-KHLWQG--LDRWQ----KDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDA 650
+ GK K ++ LD + + +++++++I+ + L+T+RC E+G++E+ +A
Sbjct 595 DKRGKPKKVFDAAVLDVLKPIVFEQREVTDEDIINWMMVPLCLETVRCLEDGIVETAAEA 654
Query 651 NVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQKQ 708
++G ++GIGF P+ GGA+++++ G+ + +++ A G ++P L+E A+ Q
Sbjct 655 DMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADQYAD-LGPLYHPTAKLREMAKNGQ 711
>Q93Q12 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
isomerase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Pseudomonas oleovorans]
Length=715
Score = 358 bits (918), Expect = 2e-116
Identities = 230/718 (32%), Positives = 366/718 (51%), Gaps = 25/718 (3%)
Query 3 AIKYEKNADNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKKTFF 62
AI + IV L D G+S N N + L ++A+ +KG+I S K F
Sbjct 7 AITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIQADASVKGVIVSSGKDVFI 66
Query 63 AGGDLDELIQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCH 122
G D+ E + E + E L VP VAA++G ALGGG E+ L
Sbjct 67 VGADITEFVDNFKLPEAELVAGNLEANRIFNAFEDLEVPTVAAISGIALGGGLEMCLAAD 126
Query 123 YRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGL 182
YR+ +K GLPEV LG+ PG GG VR+ RL+G NA ++ GK+ + A +G
Sbjct 127 YRVM--STSAKIGLPEVKLGIYPGFGGTVRLPRLIGSDNAIEWIAAGKENRAEDALKVGA 184
Query 183 VHDTAENQQELLDKAIVWVKANPKSQQPFDVKGYKIPGGDP-KTPAVAQVLAI--APAML 239
V D + L+ A+ VK + D K + P + K A+ Q++A A +
Sbjct 185 V-DAVVAPELLMAGALDLVKRAISGE--LDYKAKRQPKLEKLKLNAIEQMMAFETAKGFV 241
Query 240 RDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAI 299
+ YPAP + + A D AL +E+ F +LA +A+++IG F + +
Sbjct 242 AGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFAKLAKTSVAESLIGLFLND-QEL 300
Query 300 KSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGKAYSQK 359
K A ++A A + VLGAG+MG GIAY +A+KG P+++KD+ E + G + K
Sbjct 301 KRKAKAHDEIAH-DAKQAAVLGAGIMGGGIAYQSAVKGTPILMKDIREEAIQLGLNEASK 359
Query 360 LLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQYL 419
LL RV +GR+T K + L I T D D+++EAV EN ++K V E E +
Sbjct 360 LLGNRVEKGRLTPAKMAEALNAIRPTLSYGDFANVDIVVEAVVENPKVKQAVLAEVETQV 419
Query 420 AEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKAY 479
+ I ASNTST+ I LA A K +NF+G+HFF+PV M LVE+I+G+++S +A
Sbjct 420 KDDAILASNTSTISINLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSEVAVATTV 479
Query 480 DFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPLA 539
+ +++ K PIVVND GF +RV + +L++ GV +I+ K G P+GP
Sbjct 480 AYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAY 539
Query 540 IQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYPE 599
+ D V + H + KD ++ VD ++E NR G+ G GFY Y
Sbjct 540 LMDVVGIDTGHHGRDVMAEGFPDRMKDERRSAVD-----ALYEANRLGQKNGKGFYAYET 594
Query 600 HGKKHLWQGLDRWQKD---------HDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDA 650
+ + D D +++++++I+ + L+T+RC E+G++E+ +A
Sbjct 595 DKRGKPKKVADASVLDVLKPIVFEQREVTDEDIINWMMIPLCLETVRCLEDGIVETAAEA 654
Query 651 NVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQKQ 708
++G ++GIGF P+ GGA+++++ G+ + +++ A G ++P L+E A+ Q
Sbjct 655 DMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADQYAD-LGPLYHPTAKLREMAKNGQ 711
>P21177 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
isomerase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Escherichia coli (strain K12)]
Length=729
Score = 354 bits (908), Expect = 1e-114
Identities = 232/713 (33%), Positives = 368/713 (52%), Gaps = 31/713 (4%)
Query 11 DNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKKTFFAGGDLDEL 70
D I L D+ G S N ++ +L + L+ ++DLKG++ RS K F G D+ E
Sbjct 15 DGIAELVFDAPG-SVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEF 73
Query 71 IQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRIAINDP 130
+ + + + + + +E L VP +AA+NG ALGGG E L YR+A P
Sbjct 74 LSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLAT--P 131
Query 131 KSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHDTAENQ 190
+ GLPE LG++PG GG VRM R+LG +A + GK G DQA +GLV D
Sbjct 132 DLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLV-DGVVKA 190
Query 191 QELLD--KAIVWVKANPKSQQPFDVKGYKIPGGDP-KTPAVAQVLA--IAPAMLRDKTKG 245
++L++ KA++ N D K + P +P K + ++ IA M+
Sbjct 191 EKLVEGAKAVLRQAINGD----LDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGK 246
Query 246 CYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAIKSGASR 305
YPAP + A+ + AL +E++ F LA A+ ++G F +
Sbjct 247 HYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKL 306
Query 306 PADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGKAYSQKLLDKRV 365
DV + VLGAG+MG GIAY +A KG+PV++KD++ ++ G + KLL+K++
Sbjct 307 TKDVET--PKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQL 364
Query 366 SQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQYLAEGGIF 425
+G++ K V++ I T D A D+++EAV EN ++K V E EQ + + +
Sbjct 365 ERGKIDGLKLAGVISTIHPTLDYAGFDRVDIVVEAVVENPKVKKAVLAETEQKVRQDTVL 424
Query 426 ASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKAYDFVQQI 485
ASNTST+PI+ LA A + +NF G+HFF+PV +M LVEII+G+++S ET+AK + ++
Sbjct 425 ASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKM 484
Query 486 AKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKA-GMPVGPLAIQDEV 544
KTPIVVND GFF +RV + +LL +G KI+ K G P+GP + D V
Sbjct 485 GKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVV 544
Query 545 SLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYPEHGKKH 604
+ H + + + +D + + NR G+ G GF+ Y E K
Sbjct 545 GIDTAHHAQAVMAAGFPQRMQKDYRDAID-----ALFDANRFGQKNGLGFWRYKEDSKGK 599
Query 605 LWQGLDRWQKD---------HDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANVGSI 655
+ D +D D SE+E+I R + + +RC EEG++ + +A++ +
Sbjct 600 PKKEEDAAVEDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALV 659
Query 656 FGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQKQ 708
+G+GF P+ GGA ++L+ G + L +++ Q G + P L+ KA+ +
Sbjct 660 YGLGFPPFHGGAFRWLDTLGSAKYLDMAQQY-QHLGPLYEVPEGLRNKARHNE 711
>P28793 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
isomerase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Pseudomonas fragi]
Length=715
Score = 352 bits (903), Expect = 4e-114
Identities = 227/708 (32%), Positives = 362/708 (51%), Gaps = 25/708 (4%)
Query 13 IVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKKTFFAGGDLDELIQ 72
IV L D G+S N N + L +KA+ +KG+I S K F G D+ E ++
Sbjct 17 IVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSSGKDVFIVGADITEFVE 76
Query 73 VQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRIAINDPKS 132
E + E L VP VAA+NG ALGGG E+ L +R+ + +
Sbjct 77 NFKLPDAELIAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLEMCLAADFRVMADS--A 134
Query 133 KFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHDTAENQQE 192
K GLPEV LG+ PG GG VR+ RL+G+ NA ++ GK+ + A + V D +
Sbjct 135 KIGLPEVKLGIYPGFGGTVRLPRLIGVDNAVEWIASGKENRAEDALKVSAV-DAVVTADK 193
Query 193 LLDKAIVWVKANPKSQQPFDVKGYKIPGGDP-KTPAVAQVLAI--APAMLRDKTKGCYPA 249
L A+ +K + D K + P + K A+ Q++A A + + YPA
Sbjct 194 LGAAALDLIKRAISGE--LDYKAKRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPA 251
Query 250 PEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAIKSGASRPADV 309
P + + A D AL +E+ F +LA + +IG F + K ++ D
Sbjct 252 PVEAIKTIQKAANFGRDKALEVEAAGFAKLAKTSASNCLIGLFLNDQELKKK--AKVYDK 309
Query 310 ARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQGR 369
+ VLGAG+MG GIAY +A KG P+++KD++ E+G A + KLL RV +GR
Sbjct 310 IAKDVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVGRVDKGR 369
Query 370 MTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQYLAEGGIFASNT 429
MT K +VL I T D DL++EAV EN ++K V E E ++ E I ASNT
Sbjct 370 MTPAKMAEVLNGIRPTLSYGDFGNVDLVVEAVVENPKVKQAVLAEVENHVREDAILASNT 429
Query 430 STLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKAYDFVQQIAKTP 489
ST+ I+ LA A K +NF+G+HFF+PV M LVE+I+G+++S +A + +++ K P
Sbjct 430 STISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSDLAVATTVAYAKKMGKNP 489
Query 490 IVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMPVGPLAIQDEVSLTLT 549
IVVND GF +RV + +L++ GV +I+ K G P+GP + D V +
Sbjct 490 IVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTG 549
Query 550 EHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYPEHGKKHLWQGL 609
H + KD ++ +D ++E R G+ G GFY Y K + +
Sbjct 550 HHGRDVMAEGFPDRMKDDRRSAID-----ALYEAKRLGQKNGKGFYAYEADKKGKQKKLV 604
Query 610 DR---------WQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANVGSIFGIGF 660
D + D++++++I+ + L+T+RC E+G++E+ +A++G ++GIGF
Sbjct 605 DSSVLEVLKPIVYEQRDVTDEDIINWMMIPLCLETVRCLEDGIVETAAEADMGLVYGIGF 664
Query 661 APWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQKQ 708
+ GGA+++++ G+ + +++ A+ G ++P L+E A+ Q
Sbjct 665 PLFRGGALRYIDSIGVAEFVALADQYAE-LGALYHPTAKLREMAKNGQ 711
>Q9F0Y7 Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
isomerase/3-hydroxybutyryl-CoA epimerase / 3-hydroxyacyl-CoA
dehydrogenase [Enterobacter cloacae]
Length=729
Score = 350 bits (897), Expect = 4e-113
Identities = 227/711 (32%), Positives = 367/711 (52%), Gaps = 27/711 (4%)
Query 11 DNIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKKTFFAGGDLDEL 70
D I L D+ G S N ++ +L L+ + +LKG++ RS K F G D+ E
Sbjct 15 DGIAELVFDAPG-SVNKLDTATVASLGQALDVLEKQPELKGMLLRSNKAAFIVGADITEF 73
Query 71 IQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRIAINDP 130
+ + + + + + +E L VP ++A+NG ALGGG E L YR+A P
Sbjct 74 LSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTISAVNGYALGGGCECVLATDYRLAT--P 131
Query 131 KSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHDTAENQ 190
+ GLPE LG++PG GG VRM R+LG +A + GK G +QA+ +GLV D
Sbjct 132 DLRIGLPETRLGIMPGFGGSVRMPRMLGADSAMEIIAAGKDVGAEQAQKIGLV-DGVVKP 190
Query 191 QELLDKAIVWVKANPKSQQPFDVKGYKIPGGDP-KTPAVAQVLA--IAPAMLRDKTKGCY 247
++L++ A+ ++ D K + P +P K + ++ IA M+ Y
Sbjct 191 EKLVEGALAILRQAINGD--LDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVMQTAGKHY 248
Query 248 PAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWHGLNAIKSGASRPA 307
PAP + A++ D AL++E++ F LA A+ ++G F + + G +R
Sbjct 249 PAPITAVKTIEAAARLGRDEALKLENQSFVPLAHTNEARALVGIFLN--DQFVKGKARQL 306
Query 308 DVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQ 367
VLGAG+MG GIAY +A KG+PV++KD+S ++ G + KLL+K++ +
Sbjct 307 TKNVETPKHAAVLGAGIMGGGIAYQSAWKGVPVVMKDISEKSLTLGMTEAAKLLNKQLER 366
Query 368 GRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQEAEQYLAEGGIFAS 427
G++ K V++ I + + D+++EAV EN ++K V E E + + AS
Sbjct 367 GKIDGLKLAGVISTIQPVLEYSGFDRVDVVVEAVVENPKVKKAVLAETEDKVRPETVLAS 426
Query 428 NTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAETLAKAYDFVQQIAK 487
NTST+PI+ LA+ K +NF G+HFF+PV +M LVE+I+G++TS ET+AK + ++ K
Sbjct 427 NTSTIPISELASVLKRPENFCGMHFFNPVHRMPLVEVIRGEKTSDETIAKVVAWASKMGK 486
Query 488 TPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKA-GMPVGPLAIQDEVSL 546
TPIVVND GFF +RV + +LL +G KI+ K G P+GP + D V +
Sbjct 487 TPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGI 546
Query 547 TLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGFYEYPEHGK---- 602
H + + + +D + + NR G+ G GF+ Y E+ K
Sbjct 547 DTAHHAQAVMAAGFPQRMQKDYRDAID-----ALFDANRFGQKNGLGFWRYKENSKGKPK 601
Query 603 ---KHLWQGL--DRWQKDHDISEQEMIDRFLFVQALDTLRCYEEGVLESVIDANVGSIFG 657
+ GL D Q D ++ E+I R + + +RC EEG++ S +A++ ++G
Sbjct 602 KEEDAVVDGLLADVSQPKRDFTDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYG 661
Query 658 IGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKAQQKQ 708
+GF P+ GGA ++L+ G R L +++ Q G + P L+ KA+ +
Sbjct 662 LGFPPFHGGAFRWLDTLGSARYLDMAQQY-QHLGPLYEVPEGLRNKARHNE 711
>Q8BMS1 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-CoA
dehydrogenase [Mus musculus]
Length=763
Score = 341 bits (874), Expect = 2e-109
Identities = 232/727 (32%), Positives = 367/727 (50%), Gaps = 54/727 (7%)
Query 12 NIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-TFFAGGDLDEL 70
++ ++ ++S NT+N E + +V ++ A ++ + S+K F AG D++ L
Sbjct 48 DVAVIRINSPNSKVNTLNKEVQSEFIEVMNEIWANDQIRSAVLISSKPGCFVAGADINML 107
Query 71 IQ-VQPEHAT----EFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRI 125
P+ AT E +M EKL+ + PVVAA++G+ LGGG ELA+ C YRI
Sbjct 108 SSCTTPQEATRISQEGQRMFEKLEKSPK-------PVVAAISGSCLGGGLELAIACQYRI 160
Query 126 AINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHD 185
A D K+ G+PEV LG+LPG GG R+ +++G+ AF ++ G+ D+AK +GLV
Sbjct 161 ATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQ 220
Query 186 TAE-------NQQELLDKAIVWVKAN-PKSQQPFDVKGYKIPGGDPKTPAVA-------- 229
E + +E + + V N K V + G K A
Sbjct 221 LVEPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLVEKLTTYAMTVPFVRQ 280
Query 230 QVLAIAPAMLRDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMI 289
QV ++ +TKG YPAP I+ A G + D ES+ F +LA+ + +K ++
Sbjct 281 QVYKTVEEKVKKQTKGLYPAPLKIIDAVKAGLEQGSDAGYLAESQKFGELALTKESKALM 340
Query 290 GTFWHGLNAIKSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVEN 349
G + + K+ P ++ +LGAG+MGAGIA + KG+ +LKD +V
Sbjct 341 GLYNGQVLCKKNKFGAPQK----NVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTG 396
Query 350 AEKGKAYSQKLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKA 409
+G+ K L+ +V + +T+ +R+ + + + D + D++IEAVFE+ +K
Sbjct 397 LGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLGVKH 456
Query 410 KVTQEAEQYLAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQ 469
KV +E E E IFASNTS LPI +A SK + IG+H+FSPVDKMQL+EII +
Sbjct 457 KVLKEVESVTPEHCIFASNTSALPINQIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTDK 516
Query 470 TSAETLAKAYDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAAL 529
TS +T A A + K IVV D GF+T+R + E MR+L EGV P K++
Sbjct 517 TSKDTTASAVAVGLRQGKVIIVVKDGPGFYTTRCLAPMMSEVMRILQEGVDPKKLDALTT 576
Query 530 KAGMPVGPLAIQDEVSLTLTEHVASETRKALQAE----AKDLAKTPVDEVVHTMIHELNR 585
G PVG + DEV + + +HVA + KA + +L K V +
Sbjct 577 GFGFPVGAATLADEVGVDVAQHVAEDLGKAFGERFGGGSVELLKQMVSK---------GF 627
Query 586 KGKAAGAGFYEYPEHGK-KHLWQGLD------RWQKDHDISEQEMIDRFLFVQAL-DTLR 637
G+ +G GFY Y E K K L +D R ++S E + + + + + +
Sbjct 628 LGRKSGKGFYIYQEGSKNKSLNSEMDNILANLRLPAKPEVSSDEDVQYRVITRFVNEAVL 687
Query 638 CYEEGVLESVIDANVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPP 697
C +EG+L + + ++G++FG+GF P GG +F++ G ++ + R + YG +F P
Sbjct 688 CLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPC 747
Query 698 PYLKEKA 704
L + A
Sbjct 748 QLLLDHA 754
>P40939 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-CoA
dehydrogenase [Homo sapiens]
Length=763
Score = 337 bits (865), Expect = 5e-108
Identities = 228/723 (32%), Positives = 372/723 (51%), Gaps = 46/723 (6%)
Query 12 NIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-TFFAGGDLDEL 70
++ ++ ++S NT++ E ++V ++ A ++ + S+K F AG D++ L
Sbjct 48 DVAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINML 107
Query 71 -----IQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRI 125
+Q + + E +++EKL+ + P+VAA+NG+ LGGG E+A+ C YRI
Sbjct 108 AACKTLQEVTQLSQEAQRIVEKLEKSTK-------PIVAAINGSCLGGGLEVAISCQYRI 160
Query 126 AINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHD 185
A D K+ G PEV LG LPG GG R+ +++G+ A ++ G+ D+AK +GLV
Sbjct 161 ATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQ 220
Query 186 TAE------------NQQELLDKAIVWVKA-NPKSQQPFDVKGY--KIPGGDPKTPAVAQ 230
E + L + AI + K K P KG K+ P V Q
Sbjct 221 LVEPLGPGLKPPEERTIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQ 280
Query 231 -VLAIAPAMLRDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMI 289
V +R +TKG YPAP I+ G + D ES+ F +L + + +K ++
Sbjct 281 QVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALM 340
Query 290 GTFWHGLNAIKSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVEN 349
G + + K+ P + A +LGAG+MGAGIA + KG+ ILKD ++
Sbjct 341 GLYHGQVLCKKNKFGAPQKDVKHLA----ILGAGLMGAGIAQVSVDKGLKTILKDATLTA 396
Query 350 AEKGKAYSQKLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKA 409
++G+ K L+ +V + +T+ +R+ + + +T D + D++IEAVFE+ LK
Sbjct 397 LDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKH 456
Query 410 KVTQEAEQYLAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQ 469
+V +E E + + IFASNTS LPI+ +A SK + IG+H+FSPVDKMQL+EII ++
Sbjct 457 RVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEK 516
Query 470 TSAETLAKAYDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAAL 529
TS +T A A + K IVV D GF+T+R + E +R+L EGV P K++
Sbjct 517 TSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTT 576
Query 530 KAGMPVGPLAIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKA 589
G PVG + DEV + + +HVA + K P E++ M+ + G+
Sbjct 577 SFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFG--GGNP--ELLTQMVSK-GFLGRK 631
Query 590 AGAGFYEYPEHGK-KHLWQGLD------RWQKDHDISEQEMIDRFLFVQAL-DTLRCYEE 641
+G GFY Y E K K L +D + ++S E I L + + + + C +E
Sbjct 632 SGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQE 691
Query 642 GVLESVIDANVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLK 701
G+L + + ++G++FG+GF P GG +F++ G ++ + R ++ YG++F P L
Sbjct 692 GILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQFTPCQLLA 751
Query 702 EKA 704
+ A
Sbjct 752 DHA 754
>Q64428 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-CoA
dehydrogenase [Rattus norvegicus]
Length=763
Score = 337 bits (864), Expect = 7e-108
Identities = 229/727 (31%), Positives = 368/727 (51%), Gaps = 54/727 (7%)
Query 12 NIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-TFFAGGDLDEL 70
++ ++ ++S NT+N E + +V ++ A ++ + S+K F AG D++ L
Sbjct 48 DVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADINML 107
Query 71 IQ-VQPEHAT----EFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRI 125
P+ A E KM EKL+ + PVVAA++G+ LGGG ELA+ C YRI
Sbjct 108 ASCTTPQEAARISQEGQKMFEKLEKSPK-------PVVAAISGSCLGGGLELAIACQYRI 160
Query 126 AINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHD 185
A D K+ G+PEV LG+LPG GG R+ +++G+ AF ++ G+ D+AK +GLV
Sbjct 161 ATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQ 220
Query 186 TAE-------NQQELLDKAIVWVKAN-PKSQQPFDVKGYKIPGGDPKTPAVA-------- 229
+ + +E + + V N K V + G K + A
Sbjct 221 LVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIPFVRQ 280
Query 230 QVLAIAPAMLRDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMI 289
QV ++ +TKG YPAP I+ A G + D ES F +LA+ + +K ++
Sbjct 281 QVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTKESKALM 340
Query 290 GTFWHGLNAIKSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVEN 349
G + + K+ P + ++ +LGAG+MGAGIA + KG+ +LKD +V
Sbjct 341 GLYNGQVLCKKNKFGAPQKTVQ----QLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTG 396
Query 350 AEKGKAYSQKLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKA 409
+G+ K L+ +V + +T+ +R+ + + + D + D++IEAVFE+ +K
Sbjct 397 LGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKH 456
Query 410 KVTQEAEQYLAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQ 469
KV +E E E IFASNTS LPI +A S+ + IG+H+FSPVDKMQL+EII +
Sbjct 457 KVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDK 516
Query 470 TSAETLAKAYDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAAL 529
TS +T A A + K IVV D GF+T+R + E +R+L EGV P K++
Sbjct 517 TSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTT 576
Query 530 KAGMPVGPLAIQDEVSLTLTEHVASETRKALQAE----AKDLAKTPVDEVVHTMIHELNR 585
G PVG + DEV + + +HVA + KA + +L K V +
Sbjct 577 GFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVSK---------GF 627
Query 586 KGKAAGAGFYEYPEHGK-KHLWQGLD------RWQKDHDISEQEMIDRFLFVQAL-DTLR 637
G+ +G GFY Y K K+L +D R ++S E I + + + + +
Sbjct 628 LGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFVNEAVL 687
Query 638 CYEEGVLESVIDANVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPP 697
C +EG+L + + ++G++FG+GF P GG +F++ G ++ + R + YG +F P
Sbjct 688 CLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPC 747
Query 698 PYLKEKA 704
L++ A
Sbjct 748 QLLRDLA 754
>Q29554 Long-chain enoyl-CoA hydratase / Long chain 3-hydroxyacyl-CoA
dehydrogenase [Sus scrofa]
Length=763
Score = 335 bits (858), Expect = 5e-107
Identities = 227/719 (32%), Positives = 365/719 (51%), Gaps = 38/719 (5%)
Query 12 NIVILTLDSSGQSANTMNAEFRDALNDVSQKLKAETDLKGIIFRSAKK-TFFAGGDLDEL 70
++ ++ ++S NT+ E +V ++ + + ++ + S+K F AG D++ L
Sbjct 48 DVAVIRINSPNSKVNTLGQELHSEFIEVMNEVWSSSQIRSAVLISSKPGCFIAGADINML 107
Query 71 IQVQPEHATEFFKMIEKLKADLRTIETLGVPVVAALNGTALGGGWELALGCHYRIAINDP 130
E ++ ++ + +E P+VAA+NGT LGGG ELA+ C YRIA D
Sbjct 108 SACTTSQ--EVTQISQEAQRTFEKLEKSTKPIVAAINGTCLGGGLELAISCQYRIATKDK 165
Query 131 KSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDQAKSLGLVHDTAE-- 188
K+ G PEV LG+LPG GG R+ +++G+ AF ++ G+ D+AK +GLV E
Sbjct 166 KTVLGAPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRGIRADKAKKMGLVDQLVEPL 225
Query 189 ----------NQQELLDKAIVWVKA-NPKSQQPFDVKGY--KIPGGDPKTPAVAQ-VLAI 234
+ L + A+ + K K P KG K+ P V Q +
Sbjct 226 GPGLKPPEERTIEYLEEVAVTFAKGLADKKISPKRDKGLVEKLTSYAMSIPFVRQQIYKK 285
Query 235 APAMLRDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLAIGQIAKNMIGTFWH 294
+R +TKG YPAP I+ G + D ES+ F +LA+ + +K ++G +
Sbjct 286 VEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLSESQKFGELAMTKESKALMGLYRG 345
Query 295 GLNAIKSGASRPADVARWQATKVGVLGAGMMGAGIAYSTAIKGIPVILKDVSVENAEKGK 354
K+ P + + +LGAG+MGAGIA + K + ILKD S+ +G+
Sbjct 346 QTLCKKNKFGAPQK----EVKHLAILGAGLMGAGIAQVSVDKHLKTILKDASLPALGRGQ 401
Query 355 AYSQKLLDKRVSQGRMTAEKRNQVLALITATADAADLQGCDLIIEAVFENQELKAKVTQE 414
K L+ +V + +T+ +R+ + + +T D + D++IEAVFE LK KV +E
Sbjct 402 QQVFKGLNDKVRKKALTSFERDSLFSNLTGQLDYQGFEKADMVIEAVFEELSLKHKVLKE 461
Query 415 AEQYLAEGGIFASNTSTLPITGLATASKDAKNFIGLHFFSPVDKMQLVEIIKGKQTSAET 474
E + + +FASNTS LPI+ +A SK + IG+H+FSPVDKMQL+EII ++TS ++
Sbjct 462 VEAVIPDHCVFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDS 521
Query 475 LAKAYDFVQQIAKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPAKIEMAALKAGMP 534
A A + + K IVV D GF+T+R + E +R+L EGV P K++ G P
Sbjct 522 TASAVEVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVLRILQEGVGPKKLDSLTTSFGFP 581
Query 535 VGPLAIQDEVSLTLTEHVASETRKALQAEAKDLAKTPVDEVVHTMIHELNRKGKAAGAGF 594
VG + DEV + + +HVA K + A +D V+ MI + G+ +G GF
Sbjct 582 VGAATLMDEVGMDVAKHVAENLGKIF---GERFAGGNLD-VLKQMISK-GFLGRKSGKGF 636
Query 595 YEYPEHGKKHLWQGLD--------RWQKDHDISEQEMIDRFLFVQAL-DTLRCYEEGVLE 645
Y Y E G K+ D + DIS E I L + + + + C +EG+L
Sbjct 637 YVYQE-GVKNRNVNSDTESILASLKIPSRPDISSDEDIQYRLVTRFVNEAVLCLQEGILA 695
Query 646 SVIDANVGSIFGIGFAPWTGGAIQFLNQNGIERSLQRSEELAQKYGERFNPPPYLKEKA 704
+ + ++G++FG+GF P GG +F++ G ++ + R + YG++F P L + A
Sbjct 696 TPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYEAIYGKQFTPCQLLIDHA 754
Lambda K H a alpha
0.318 0.134 0.385 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 9076242
Database: 2d729be6bb37d70ec25235d3835202fa.SwissProt.fasta
Posted date: May 19, 2024 5:17 AM
Number of letters in database: 15,223
Number of sequences in database: 21
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
