BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: b89c945816be4efd3bdfca7bcae61d03.SwissProt.fasta
16 sequences; 4,958 total letters
Query= ACIAD3074
Length=292
Score E
Sequences producing significant alignments: (Bits) Value
P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str... 140 3e-43
Q9SZE1 Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitoch... 130 7e-39
O34948 Uncharacterized oxidoreductase YkwC [Bacillus subtilis (st... 127 4e-38
P0ABQ3 2-hydroxy-3-oxopropionate reductase [Escherichia coli O6:H... 123 1e-36
P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli (str... 123 1e-36
Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aerugino... 119 4e-35
Q55702 Uncharacterized oxidoreductase slr0229 [Synechocystis sp. ... 117 1e-34
F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplasti... 118 2e-34
Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial... 112 2e-32
Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium bark... 111 4e-32
Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Bos tau... 110 1e-31
Q9LSV0 Glyoxylate/succinic semialdehyde reductase 1 [Arabidopsis ... 106 3e-30
P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo sa... 105 1e-29
P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Rattus ... 104 2e-29
O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigi... 103 4e-29
P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa... 98.2 3e-27
>P77161 2-hydroxy-3-oxopropionate reductase [Escherichia coli
(strain K12)]
Length=292
Score = 140 bits (353), Expect = 3e-43
Identities = 89/284 (31%), Positives = 149/284 (52%), Gaps = 7/284 (2%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIADYP--VILM 66
+ FIG+G+MG+ MA L +AG + V D LL +GA ++ + +I +
Sbjct 3 LGFIGLGIMGTPMAINLARAGHQLHV-TTIGPVADELLSLGAVSVETARQVTEASDIIFI 61
Query 67 CLADDQAVNHVYEQVHHLVRPQ---QIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
+ D V V + + + IVD SS+S +TK A + + ++D+PVSG
Sbjct 62 MVPDTPQVEEVLFGENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSG 121
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
G GA +GTL I GG+E+ + + ++ +L + +T +G G GQ K+ NQ+IVA N
Sbjct 122 GEIGAREGTLSIMVGGDEAVFERVKPLFELLGKNITLVGGNGDGQTCKVANQIIVALNIE 181
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDLN 243
++EA+ A +AG D + AL GFA S+ ++ RM ++ F P +K+ KDLN
Sbjct 182 AVSEALLFASKAGADPVRVRQALMGGFASSRILEVHGERMIKRTFNP-GFKIALHQKDLN 240
Query 244 NAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVE 287
A++ A AL++P ++ NG +Q D + +++ +E
Sbjct 241 LALQSAKALALNLPNTATCQELFNTCAANGGSQLDHSALVQALE 284
>Q9SZE1 Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial
[Arabidopsis thaliana]
Length=334
Score = 130 bits (326), Expect = 7e-39
Identities = 87/297 (29%), Positives = 152/297 (51%), Gaps = 21/297 (7%)
Query 6 HTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQ-ALSLEKIADYPVI 64
+T I +IG G+MG M L++AG++V V+NRT S L+DMGA A S +A+ +
Sbjct 37 NTKIGWIGTGVMGRSMCGHLIKAGYTVTVFNRTISKAQTLIDMGANVADSPNSVAEQSDV 96
Query 65 LMCLADDQAVNHVYEQVHHLVRPQQ----------IIVDFSSLSVNQTKYLADRAQQQQA 114
+ + V + + H L+ P+ ++VD ++ + + +A A +
Sbjct 97 VFTI-----VGYPSDVRHVLLDPKSGALSGLRQGGVLVDMTTSEPSLAEEIAKAASFKNC 151
Query 115 IWIDSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICN 174
ID+PVSGG GA+ G L IFAGG+E+T++ L +++++ +V MG +G GQ K+ N
Sbjct 152 FSIDAPVSGGDLGAKNGKLSIFAGGDETTVKRLDPLFSLMG-KVNFMGTSGKGQFAKLAN 210
Query 175 QLIVAANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWK 234
Q+ +A+ + E + AH+AG+D A++ G A SK + R+ ++ F+P +
Sbjct 211 QITIASTMLGLVEGLIYAHKAGLDVKKFLEAISTGAAGSKSIDLYGDRILKRDFDP-GFY 269
Query 235 VQTLAKDLNNAVELATHYALDIP---VAHQALHQLHSHQQNGYAQSDLATMIKQVED 288
V KDL + L +P +A Q L +H + L ++++ +
Sbjct 270 VNHFVKDLGICLNECQRMGLALPGLALAQQLYLSLKAHGEGDLGTQALLLALERLNN 326
>O34948 Uncharacterized oxidoreductase YkwC [Bacillus subtilis
(strain 168)]
Length=288
Score = 127 bits (318), Expect = 4e-38
Identities = 80/256 (31%), Positives = 136/256 (53%), Gaps = 10/256 (4%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGA----QALSLEKIADYPVI 64
I FIG+G+MG MA+ ++ G V V+ RT+ + +L GA L K AD VI
Sbjct 5 IGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQKGAIWKDTVKDLSKEAD--VI 62
Query 65 LMCLADDQAVNHVYEQVHHLVRPQQ---IIVDFSSLSVNQTKYLADRAQQQQAIWIDSPV 121
+ + V VY + ++ + ++D ++ + K +A+ A+++ +D+PV
Sbjct 63 ITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSLAKKIAEAAKEKALFALDAPV 122
Query 122 SGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAAN 181
SGG GA+ GTL I GG + + I++++ + + G G+GQ TK+CNQ+ +AA
Sbjct 123 SGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQYQGPAGSGQHTKMCNQIAIAAG 182
Query 182 SALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKD 241
+AEA+A A ++G++ + ++ G A S LAPRM + FEP + V+ KD
Sbjct 183 MIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLSNLAPRMLQGNFEP-GFYVKHFIKD 241
Query 242 LNNAVELATHYALDIP 257
+ A+E A ++P
Sbjct 242 MGIALEEAELMGEEMP 257
Score = 19.6 bits (39), Expect = 1.3
Identities = 9/23 (39%), Positives = 14/23 (61%), Gaps = 0/23 (0%)
Query 237 TLAKDLNNAVELATHYALDIPVA 259
+LAK + A + +ALD PV+
Sbjct 101 SLAKKIAEAAKEKALFALDAPVS 123
>P0ABQ3 2-hydroxy-3-oxopropionate reductase [Escherichia coli
O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=294
Score = 123 bits (308), Expect = 1e-36
Identities = 78/275 (28%), Positives = 145/275 (53%), Gaps = 6/275 (2%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEK-IADY-PVILM 66
+ FIG+G+MG M+ L++AG+S+ V +R A ++ GA+ S K IA+ VI+
Sbjct 3 VGFIGLGIMGKPMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVIIT 62
Query 67 CLADDQAVNHVYEQVHHLV---RPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
L + V V + ++ +P +++D SS++ ++ +++ + + +D+PVSG
Sbjct 63 MLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSG 122
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
G A GTL + GG+++ + ++ V G+ G G TK+ NQ+IVA N A
Sbjct 123 GEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIA 182
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDLN 243
++EA+ LA +AGV+ L+ A+ G A S AP + + F+P +++ KDL
Sbjct 183 AMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKP-GFRIDLHIKDLA 241
Query 244 NAVELATHYALDIPVAHQALHQLHSHQQNGYAQSD 278
NA++ + +P+ + + + + +G +D
Sbjct 242 NALDTSHGVGAQLPLTAAVMEMMQALRADGLGTAD 276
>P0ABQ2 2-hydroxy-3-oxopropionate reductase [Escherichia coli
(strain K12)]
Length=294
Score = 123 bits (308), Expect = 1e-36
Identities = 78/275 (28%), Positives = 145/275 (53%), Gaps = 6/275 (2%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEK-IADY-PVILM 66
+ FIG+G+MG M+ L++AG+S+ V +R A ++ GA+ S K IA+ VI+
Sbjct 3 VGFIGLGIMGKPMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVIIT 62
Query 67 CLADDQAVNHVYEQVHHLV---RPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
L + V V + ++ +P +++D SS++ ++ +++ + + +D+PVSG
Sbjct 63 MLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSG 122
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
G A GTL + GG+++ + ++ V G+ G G TK+ NQ+IVA N A
Sbjct 123 GEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIA 182
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDLN 243
++EA+ LA +AGV+ L+ A+ G A S AP + + F+P +++ KDL
Sbjct 183 AMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKP-GFRIDLHIKDLA 241
Query 244 NAVELATHYALDIPVAHQALHQLHSHQQNGYAQSD 278
NA++ + +P+ + + + + +G +D
Sbjct 242 NALDTSHGVGAQLPLTAAVMEMMQALRADGLGTAD 276
>Q9I5I6 NAD-dependent L-serine dehydrogenase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298
Score = 119 bits (298), Expect = 4e-35
Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 11/287 (4%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQAL--SLEKIADYPVILM 66
IAFIG+G MG+ MAT L++AG+ + V++ QSA D L+ GA A + + + V++
Sbjct 4 IAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGASAARSARDAVQGADVVIS 63
Query 67 CLADDQAVNHVYEQVHHL---VRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
L Q V +Y L + P ++++ S+++ + + A+++ +D+PVSG
Sbjct 64 MLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAPVSG 123
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
GT+GA GTL GG+ ++ ++ + + + G G GQ K+CN ++A
Sbjct 124 GTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAVLMI 183
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQ------WKVQT 237
AEA+AL G++ +LA + + ++ P P + Q
Sbjct 184 GTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPWPGVMENAPASRDYSGGFMAQL 243
Query 238 LAKDLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIK 284
+AKDL A E A A P+ AL + GYA+ D + + K
Sbjct 244 MAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQK 290
>Q55702 Uncharacterized oxidoreductase slr0229 [Synechocystis
sp. (strain PCC 6803 / Kazusa)]
Length=290
Score = 117 bits (294), Expect = 1e-34
Identities = 77/248 (31%), Positives = 125/248 (50%), Gaps = 8/248 (3%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIA----DYPVI 64
IA G+G+MGS MA LV+ G+ +NRT V A + IA + +I
Sbjct 6 IAVFGLGVMGSPMAQNLVKNGYQTVGYNRTLERPSVQEAAKAGVKVVTSIAVAAANADII 65
Query 65 LMCLADDQAVNHVY---EQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPV 121
L C+ D++ V + + +PQ +I+D S++ LA + Q ++D+PV
Sbjct 66 LTCVGDEKDVQQLILGSGGIAEYAKPQALIIDCSTIGKTAAYELATNLKLQGLRFLDAPV 125
Query 122 SGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAAN 181
+GG GA GTL I GG+ S ++ + + +++ G +G+GQA K+CNQ++ +
Sbjct 126 TGGDVGAINGTLTIMVGGDISDFEEALPVLKSIGEKIVHCGPSGSGQAVKLCNQVLCGIH 185
Query 182 SALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKD 241
+ AEA+ L+ + G+ L+ +G A S LAP+M+ F P + V+ L KD
Sbjct 186 AIAAAEAIQLSEQLGIAPELVIDTCGSGAAGSWALTNLAPKMSEADFAP-GFMVKHLLKD 244
Query 242 LNNAVELA 249
L E A
Sbjct 245 LRLVREAA 252
>F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplastic
[Arabidopsis thaliana]
Length=358
Score = 118 bits (296), Expect = 2e-34
Identities = 74/284 (26%), Positives = 142/284 (50%), Gaps = 6/284 (2%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSL--EKIADYPVILM 66
I F+GMG+MGS MA L++AG V VWNRT+S CD L+ +GA+ S E A +
Sbjct 69 IGFLGMGIMGSPMAQNLIKAGCDVTVWNRTKSKCDPLVGLGAKYKSSPEEVTATCDLTFA 128
Query 67 CLADDQAVNHVYEQVHHLV---RPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
LAD ++ V + + + VD S++ V + ++ + + A+++++PVSG
Sbjct 129 MLADPESAIDVACGKNGAIFGISSGKGYVDVSTVDVASSILISKQIKDTGALFLEAPVSG 188
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
AE G L+ G++ + +++ + +G+ G G A K+ +I+ + A
Sbjct 189 SKKPAEDGQLIFLTAGDKPLYEKAAPFLDIMGKSKFYLGEVGNGAAMKLVVNMIMGSMMA 248
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDLN 243
AE + L+ + G+D +L ++ G ++ + + P M + ++ P + ++ KD+
Sbjct 249 SFAEGILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVY-PTAFPLKHQQKDMR 307
Query 244 NAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVE 287
A+ LA + P+A A + G + D + +I+ ++
Sbjct 308 LALGLAESVSQSTPIAAAANELYKVAKSYGLSDEDFSAVIEALK 351
>Q9V8M5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
[Drosophila melanogaster]
Length=324
Score = 112 bits (280), Expect = 2e-32
Identities = 66/200 (33%), Positives = 113/200 (57%), Gaps = 7/200 (4%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS----LEKIADYPVI 64
I F+G+G MG+ MA+ L++AG + V++ ++ ACD L GA + L K +D+ +
Sbjct 31 IGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYAKTSELAKNSDF--V 88
Query 65 LMCLADDQAVNHVYEQVH-HLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
+ L ++ V+ Y+++ V I +D S++S + K L + + A +ID+PVSG
Sbjct 89 ITMLPNNAIVDASYDEMTADGVNKDTIFIDSSTISPDLVKSLQKKISAKGARFIDAPVSG 148
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
G GAEQ TL GG E+ + + + +++T G G GQA K+CN +++A +
Sbjct 149 GVPGAEQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNMMLAISMI 208
Query 184 LIAEAVALAHRAGVDTTLLA 203
++EA+ LA R G+D + A
Sbjct 209 GVSEAMNLAVRQGLDANVFA 228
>Q0QLF5 2-(hydroxymethyl)glutarate dehydrogenase [Eubacterium
barkeri]
Length=301
Score = 111 bits (277), Expect = 4e-32
Identities = 77/286 (27%), Positives = 133/286 (47%), Gaps = 5/286 (2%)
Query 4 DRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEK--IADY 61
++ I FIG+G MG MA L++ G +V ++ ++ ++ GAQA + A
Sbjct 2 EKSIKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQACENNQKVAAAS 61
Query 62 PVILMCLADDQAVNHVYEQ---VHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWID 118
+I L + V V V + +IVD SS+S + T +A A ++ ++D
Sbjct 62 DIIFTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVD 121
Query 119 SPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIV 178
+PVSGGT GAE GTL I G +E+ + + + +V+ + + +GDTG G A KI N L++
Sbjct 122 APVSGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLL 181
Query 179 AANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTL 238
N A +AEA+ L + G+ + + S + + + +
Sbjct 182 GCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKFIMSGDFAGGFAMDLQ 241
Query 239 AKDLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIK 284
KDL A+E + +P+ A + G + D++ +IK
Sbjct 242 HKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIK 287
>Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Bos
taurus]
Length=336
Score = 110 bits (276), Expect = 1e-31
Identities = 85/300 (28%), Positives = 142/300 (47%), Gaps = 21/300 (7%)
Query 7 TPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS-----LEK---- 57
TP+ FIG+G MG+ MA L++ G+ + +++ AC LD G Q +S EK
Sbjct 40 TPVGFIGVGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFLDAGEQVVSSPADVAEKADRI 99
Query 58 IADYPVILMCLADDQAVNHVYEQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWI 117
I P + + N + ++V + +++D S++ +K LA ++ A+++
Sbjct 100 ITMLPTSINAIEAYSGANGILKKV----KKGSLLIDSSTIDPMVSKELAKEVEKMGAVFM 155
Query 118 DSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLI 177
D+PVSGG A G L GG E + + V G GTGQA KICN L+
Sbjct 156 DAPVSGGVGAARSGNLTFMVGGVEEEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNLL 215
Query 178 VAANSALIAEAVALAHRAGVDTTLLAPAL--ANGFADSKPFQILAPRMARQIFEPVQWK- 234
+A + AEA+ L R G+D LLA L ++G S P + + ++
Sbjct 216 LAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQG 275
Query 235 ---VQTLAKDLNNAVELATHYALDIPVAHQALHQLHSHQ-QNGYAQSDLATMIKQVEDQD 290
+AKDL A + AT I + QA HQ++ GY++ D +++ + + +++
Sbjct 276 GFGTTLMAKDLGLAQDSATSTKSPILLGSQA-HQIYRMMCAKGYSKKDFSSVFQFLREEE 334
>Q9LSV0 Glyoxylate/succinic semialdehyde reductase 1 [Arabidopsis
thaliana]
Length=289
Score = 106 bits (264), Expect = 3e-30
Identities = 73/284 (26%), Positives = 137/284 (48%), Gaps = 6/284 (2%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS--LEKIADYPVILM 66
+ F+G+G+MG M+ L++ GF V VWNRT S CD L++ GA E I +
Sbjct 3 VGFLGLGIMGKAMSMNLLKNGFKVTVWNRTLSKCDELVEHGASVCESPAEVIKKCKYTIA 62
Query 67 CLADD-QAVNHVYEQ--VHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
L+D A++ V+++ V + + +D S++ + + + + +++ PVSG
Sbjct 63 MLSDPCAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFVEGPVSG 122
Query 124 GTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANSA 183
AE G L+I A G+++ ++ ++VL +R +G G G K+ +I+ +
Sbjct 123 SKKPAEDGQLIILAAGDKALFEESIPAFDVLGKRSFYLGQVGNGAKMKLIVNMIMGSMMN 182
Query 184 LIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDLN 243
+E + LA ++G+ + L L G + F+ P M + + P + ++ KD+
Sbjct 183 AFSEGLVLADKSGLSSDTLLDILDLGAMTNPMFKGKGPSMNKSSYPPA-FPLKHQQKDMR 241
Query 244 NAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVE 287
A+ L A+ +PVA A + G D + +I+ V+
Sbjct 242 LALALGDENAVSMPVAAAANEAFKKARSLGLGDLDFSAVIEAVK 285
>P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Homo
sapiens]
Length=336
Score = 105 bits (262), Expect = 1e-29
Identities = 82/300 (27%), Positives = 140/300 (47%), Gaps = 21/300 (7%)
Query 7 TPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS-----LEK---- 57
TP+ FIG+G MG+ MA L++ G+ + +++ AC D G Q +S EK
Sbjct 40 TPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRI 99
Query 58 IADYPVILMCLADDQAVNHVYEQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWI 117
I P + + N + ++V + +++D S++ +K LA ++ A+++
Sbjct 100 ITMLPTSINAIEAYSGANGILKKV----KKGSLLIDSSTIDPAVSKELAKEVEKMGAVFM 155
Query 118 DSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLI 177
D+PVSGG A G L GG E + + V G GTGQA KICN ++
Sbjct 156 DAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNML 215
Query 178 VAANSALIAEAVALAHRAGVDTTLLAPAL--ANGFADSKPFQILAPRMARQIFEPVQWK- 234
+A + AEA+ L R G+D LLA L ++G S P + + ++
Sbjct 216 LAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQG 275
Query 235 ---VQTLAKDLNNAVELATHYALDIPVAHQALHQLHSHQ-QNGYAQSDLATMIKQVEDQD 290
+AKDL A + AT I + A HQ++ GY++ D +++ + + +++
Sbjct 276 GFGTTLMAKDLGLAQDSATSTKSPILLGSLA-HQIYRMMCAKGYSKKDFSSVFQFLREEE 334
>P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Rattus
norvegicus]
Length=335
Score = 104 bits (260), Expect = 2e-29
Identities = 81/300 (27%), Positives = 142/300 (47%), Gaps = 21/300 (7%)
Query 7 TPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS----LEKIADYP 62
TP+ FIG+G MG+ MA L++ G+ + +++ C + G Q S + + AD
Sbjct 39 TPVGFIGLGNMGNPMAKNLIKHGYPLILYDVFPDVCKEFKEAGEQVASSPADVAEKADR- 97
Query 63 VILMCLADDQAVNHVYEQVHHL---VRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDS 119
I+ L VY + + V+ +++D S++ + +K LA ++ A+++D+
Sbjct 98 -IITMLPSSMNSIEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDA 156
Query 120 PVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVA 179
PVSGG A G L GG E+ + + V G G+GQ+ KICN +++A
Sbjct 157 PVSGGVGAARSGNLTFMVGGVENEFAAAQELLGCMGSNVLYCGAVGSGQSAKICNNMLLA 216
Query 180 ANSALIAEAVALAHRAGVDTTLLAPAL--ANGFADSKPFQILAPRMARQIFEPVQWK--- 234
+ AEA+ L R+G+D LLA L ++G S P + + ++
Sbjct 217 ISMIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSSNNYQGGF 276
Query 235 -VQTLAKDLNNAVELATHYALDI---PVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQD 290
+AKDL A + AT I VAHQ + S GY++ D +++ + + +++
Sbjct 277 GTTLMAKDLGLAQDSATSTKTPILLGSVAHQIYRMMCS---KGYSKKDFSSVFQYLREEE 333
>O33730 Uncharacterized oxidoreductase Sfri_1503 [Shewanella frigidimarina
(strain NCIMB 400)]
Length=291
Score = 103 bits (256), Expect = 4e-29
Identities = 71/257 (28%), Positives = 125/257 (49%), Gaps = 7/257 (3%)
Query 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDM-GAQALSLEKIA--DYPVIL 65
+AFIG+G+MG MA LV+ G V V+NRT + ++ G + K A ++
Sbjct 4 VAFIGLGVMGFPMAGHLVKQGHDVTVYNRTGAKATQWVEQYGGKKADTPKDAAQGQDIVF 63
Query 66 MCLADDQAVNHVYEQVHHLVRPQQ---IIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVS 122
C+ +D + V H +V I+VD ++ S + + +A + ++D+PVS
Sbjct 64 TCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLDAPVS 123
Query 123 GGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAANS 182
GG +GAE G L + GG+++ + + + S+ +G G GQ TK+ NQ+ +A
Sbjct 124 GGQAGAENGALTVMMGGDQAHFDTVKPVISAYSRCAELLGPVGAGQLTKMVNQICIAGVV 183
Query 183 ALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAKDL 242
+AE + A AG+D + ++ G A S + M + ++ + + + KDL
Sbjct 184 QGLAEGLHFAKSAGLDGLKVIEVISKGAAQSWQMENRYKTMWQGQYD-FGFAIDWMRKDL 242
Query 243 NNAVELATHYALDIPVA 259
A++ A +PVA
Sbjct 243 GIALDEARRNGSHLPVA 259
>P28811 3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa
(strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847
/ LMG 12228 / 1C / PRS 101 / PAO1)]
Length=298
Score = 98.2 bits (243), Expect = 3e-27
Identities = 78/297 (26%), Positives = 135/297 (45%), Gaps = 13/297 (4%)
Query 7 TPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQAL--SLEKIADYPVI 64
T IAF+G+G MG MA L++AG V V++ A L++ GAQ +L+ V+
Sbjct 2 TDIAFLGLGNMGGPMAANLLKAGHRVNVFDLQPKAVLGLVEQGAQGADSALQCCEGAEVV 61
Query 65 LMCLADDQAVNHVY---EQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPV 121
+ L Q V +Y + + V + +++D S+++ + +A+ A + +D+PV
Sbjct 62 ISMLPAGQHVESLYLGDDGLLARVAGKPLLIDCSTIAPETARKVAEAAAAKGLTLLDAPV 121
Query 122 SGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAAN 181
SGG GA GTL GG + + + + GD G GQ KICN +++
Sbjct 122 SGGVGGARAGTLSFIVGGPAEGFARARPVLENMGRNIFHAGDHGAGQVAKICNNMLLGIL 181
Query 182 SALIAEAVALAHRAGVDTTLLAPALANGFADS------KPFQILAPRMARQIFEPVQWKV 235
A AEA+AL + G+D +L+ + + P+ + P+ ++V
Sbjct 182 MAGTAEALALGVKNGLDPAVLSEVMKQSSGGNWALNLYNPWPGVMPQAPASNGYAGGFQV 241
Query 236 QTLAKDLNNAVELATHYALDIPVAHQA--LHQLHSHQQNGYAQSDLATMIKQVEDQD 290
+ + KDL A+ A P+ A L LH+ + D +++ K +D
Sbjct 242 RLMNKDLGLALANAQAVQASTPLGALARNLFSLHAQADAEHEGLDFSSIQKLYRGKD 298
Lambda K H a alpha
0.322 0.133 0.386 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1046786
Database: b89c945816be4efd3bdfca7bcae61d03.SwissProt.fasta
Posted date: May 18, 2024 5:49 PM
Number of letters in database: 4,958
Number of sequences in database: 16
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
Loading
Data ...
