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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
UER00228 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10~1 H(+) + 1 NADH + 1 cobalt-precorrin-6A => 1 NAD(+) + 1 cobalt-precorrin-6B. None - {{∅}} True - {{t}} Unconfirmed presence
UER00233 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7~1 ATP + 1 cob(I)yrinic acid a,c-diamide => 1 adenosylcob(III)yrinic acid a,c-diamide + 1 triphosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UER00226 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 4 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 5A. None - {{∅}} True - {{t}} Unconfirmed presence
VariantPath-2-UER00236 None - {{∅}} None - {{∅}} Unexplained
VariantPath-1-UER00236 None - {{∅}} True - {{t}} Unconfirmed presence
UCR05227 ATP + Co(2+) + H(2)O + hydrogenobyrinic acid a,c-diamide = ADP + H(+) + cob(II)yrinate a,c-diamide + phosphate None - {{∅}} None - {{∅}} Unexplained
UCR05815 2 ATP + 2 H(2)O + 2 L-glutamine + cob(III)yrinic acid = 2 ADP + 2 L-glutamate + cob(II)yrinate a,c-diamide + 2 phosphate None - {{∅}} True - {{t}} Unconfirmed presence
ULS00093 adenosylcobalamin from cob(II)yrinate a,c-diamide None - {{∅}} None - {{∅},{t}} Unexplained
UER00230 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10~1 cobalt-precorrin 8 => 1 cob(III)yrinic acid. None - {{∅}} True - {{t}} Unconfirmed presence
UER00225 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 3 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 4. None - {{∅}} None - {{∅}} Unexplained
UER00229 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10~2 S-adenosyl-L-methionine + 1 cobalt-precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 8. None - {{∅}} None - {{∅}} Unexplained
UER00219 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10~1 precorrin-8X => 1 hydrogenobyrinic acid. None - {{∅}} None - {{∅}} Unexplained
ULS00173 sirohydrochlorin from precorrin-2 None - {{∅}} True - {{t}} Unconfirmed presence
UER00234 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7~4 ATP + 4 H(2)O + 4 L-glutamine + 1 adenosylcob(III)yrinic acid a,c-diamide => 4 ADP + 4 L-glutamate + 1 adenosylcobyrinic acid a,c-diamide + 4 phosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UCR07773 S-adenosyl-L-methionine + cobalt-precorrin 5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A None - {{∅}} None - {{∅}} Unexplained
UER00211 precorrin-2 from uroporphyrinogen III: step 1/1~2 S-adenosyl-L-methionine + 1 uroporphyrinogen III => 2 S-adenosyl-L-homocysteine + 1 precorrin-2. None - {{∅}} True - {{t}} Unconfirmed presence
VariantPath-2-UPA00148 None - {{∅}} None - {{∅},{t}} Unexplained
UER00214 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10~1 S-adenosyl-L-methionine + 1 precorrin-3B => 1 S-adenosyl-L-homocysteine + 1 precorrin-4. None - {{∅}} None - {{∅}} Unexplained
VariantPath-1-UPA00148 None - {{∅}} None - {{∅},{t}} Unexplained
UER00236 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7~adenosylcobinamide + [ATP or GTP] => adenosylcobinamide phosphate + [ADP or GDP]. None - {{∅}} True - {{t}} Unconfirmed presence
UCR03947 NAD(+) + precorrin-2 = H(+) + NADH + sirohydrochlorin None - {{∅}} True - {{t}} Unconfirmed presence
UCR05150 NADP(+) + precorrin-6B = H(+) + NADPH + precorrin-6A None - {{∅}} None - {{∅}} Unexplained
ULS00091 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) None - {{∅}} None - {{∅},{t}} Unexplained
UER00215 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10~1 S-adenosyl-L-methionine + 1 precorrin-4 => 1 S-adenosyl-L-homocysteine + 1 precorrin-5. None - {{∅}} None - {{∅}} Unexplained
UER00221 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10~1 ATP + 1 Co(2+) + 1 H(2)O + 1 hydrogenobyrinic acid a,c-diamide => 1 ADP + 1 H(+) + 1 cob(II)yrinate a,c-diamide + 1 phosphate. None - {{∅}} None - {{∅}} Unexplained
UCR05149 2 S-adenosyl-L-methionine + precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + precorrin-8X None - {{∅}} None - {{∅}} Unexplained
UER00222 sirohydrochlorin from precorrin-2: step 1/1~1 NAD(+) + 1 precorrin-2 => 1 H(+) + 1 NADH + 1 sirohydrochlorin. None - {{∅}} True - {{t}} Unconfirmed presence
UCR05226 (R)-1-aminopropan-2-ol + adenosylcobyrinic acid a,c-diamide = H(2)O + adenosylcobinamide None - {{∅}} None - {{∅}} Unexplained
UCR05813 2 S-adenosyl-L-methionine + cobalt-precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + cobalt-precorrin 8 None - {{∅}} None - {{∅}} Unexplained
UER00217 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10~1 H(+) + 1 NADPH + 1 precorrin-6A => 1 NADP(+) + 1 precorrin-6B. None - {{∅}} None - {{∅}} Unexplained
ULS00090 precorrin-2 from uroporphyrinogen III None - {{∅}} True - {{t}} Unconfirmed presence
UCR05808 S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-factor III None - {{∅}} True - {{t}} Unconfirmed presence
UER00561 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10~1 H(2)O + 1 cobalt-precorrin 5A => 1 acetaldehyde + 1 cobalt-precorrin 5B. None - {{∅}} None - {{∅}} Unexplained
UER00954 None~1 GTP + 1 adenosylcobinamide => 1 GDP + 1 adenosylcobinamide phosphate. None - {{∅}} None - {{∅}} Unexplained
UCR07772 H(2)O + cobalt-precorrin 5A = acetaldehyde + cobalt-precorrin 5B None - {{∅}} None - {{∅}} Unexplained
UCR05177 precorrin-8X = hydrogenobyrinic acid None - {{∅}} None - {{∅}} Unexplained
UCR03194 2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 None - {{∅}} None - {{∅}} Unexplained
UER00218 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10~2 S-adenosyl-L-methionine + 1 precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 precorrin-8X. None - {{∅}} None - {{∅}} Unexplained
UCR05218 FMNH(2) + 2 cob(II)yrinate a,c-diamide = FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide None - {{∅}} None - {{∅}} Unexplained
UER00235 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7~1 (R)-1-aminopropan-2-ol + 1 adenosylcobyrinic acid a,c-diamide => 1 H(2)O + 1 adenosylcobinamide. None - {{∅}} None - {{∅}} Unexplained
UER00227 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 5B => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin-6A. None - {{∅}} None - {{∅}} Unexplained
UER00232 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7~1 FMNH(2) + 2 cob(II)yrinate a,c-diamide => 1 FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide. None - {{∅}} None - {{∅}} Unexplained
UCR05217 H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B None - {{∅}} None - {{∅}} Unexplained
UCR05810 S-adenosyl-L-methionine + cobalt-precorrin 4 = S-adenosyl-L-homocysteine + cobalt-precorrin 5A None - {{∅}} True - {{t}} Unconfirmed presence
UCR05181 S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 None - {{∅}} None - {{∅}} Unexplained
UCR03948 S-adenosyl-L-methionine + precorrin-2 = H(+) + S-adenosyl-L-homocysteine + precorrin-3A None - {{∅}} None - {{∅}} Unexplained
UER00223 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10~1 Co(2+) + 1 sirohydrochlorin => 2 H(+) + 1 cobalt-precorrin-2. None - {{∅}} True - {{t}} Unconfirmed presence
UER00237 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7~1 GTP + 1 adenosylcobinamide phosphate => 1 adenosylcobinamide-GDP + 1 diphosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UER00220 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10~2 ATP + 2 H(2)O + 2 L-glutamine + 1 hydrogenobyrinic acid => 2 ADP + 2 L-glutamate + 1 hydrogenobyrinic acid a,c-diamide + 2 phosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UER00216 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10~1 H(2)O + 1 S-adenosyl-L-methionine + 1 precorrin-5 => 1 S-adenosyl-L-homocysteine + 1 acetate + 1 precorrin-6A. None - {{∅}} None - {{∅}} Unexplained
UCR05221 ATP + adenosylcobinamide = ADP + adenosylcobinamide phosphate None - {{∅}} True - {{t}} Unconfirmed presence
UER00238 adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7~1 adenosylcobinamide-GDP + 1 alpha-ribazole => 1 GMP + 1 adenosylcobalamin. None - {{∅}} True - {{t}} Unconfirmed presence
UCR05222 GTP + adenosylcobinamide phosphate = adenosylcobinamide-GDP + diphosphate None - {{∅}} True - {{t}} Unconfirmed presence
UCR05225 4 ATP + 4 H(2)O + 4 L-glutamine + adenosylcob(III)yrinic acid a,c-diamide = 4 ADP + 4 L-glutamate + adenosylcobyrinic acid a,c-diamide + 4 phosphate None - {{∅}} True - {{t}} Unconfirmed presence
UCR06558 GTP + adenosylcobinamide = GDP + adenosylcobinamide phosphate None - {{∅}} None - {{∅}} Unexplained
ULS00092 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) None - {{∅}} None - {{∅},{t}} Unexplained
UCR08716 cobalt-factor III = cobalt-precorrin 3 None - {{∅}} None - {{∅}} Unexplained
UCR05219 S-adenosyl-L-homocysteine + acetate + precorrin-6A = H(2)O + S-adenosyl-L-methionine + precorrin-5 None - {{∅}} None - {{∅}} Unexplained
UCR05220 ATP + cob(I)yrinic acid a,c-diamide = adenosylcob(III)yrinic acid a,c-diamide + triphosphate None - {{∅}} True - {{t}} Unconfirmed presence
UCR05814 cobalt-precorrin 8 = cob(III)yrinic acid None - {{∅}} True - {{t}} Unconfirmed presence
UER00953 None~1 ATP + 1 adenosylcobinamide => 1 ADP + 1 adenosylcobinamide phosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UER00231 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10~2 ATP + 2 H(2)O + 2 L-glutamine + 1 cob(III)yrinic acid => 2 ADP + 2 L-glutamate + 1 cob(II)yrinate a,c-diamide + 2 phosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UER00213 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10~1 H(+) + 1 NADH + 1 O(2) + 1 precorrin-3A => 1 H(2)O + 1 NAD(+) + 1 precorrin-3B. None - {{∅}} None - {{∅}} Unexplained
UCR05224 2 ATP + 2 H(2)O + 2 L-glutamine + hydrogenobyrinic acid = 2 ADP + 2 L-glutamate + hydrogenobyrinic acid a,c-diamide + 2 phosphate None - {{∅}} True - {{t}} Unconfirmed presence
UCR05807 Co(2+) + sirohydrochlorin = 2 H(+) + cobalt-precorrin-2 None - {{∅}} True - {{t}} Unconfirmed presence
UCR05180 S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 None - {{∅}} None - {{∅}} Unexplained
UCR05809 S-adenosyl-L-methionine + cobalt-precorrin 3 = S-adenosyl-L-homocysteine + cobalt-precorrin 4 None - {{∅}} None - {{∅}} Unexplained
UPA00148 adenosylcobalamin biosynthesis~Biosynthesis of adenosylcobalamin (vitamin B12), a modified tetrapyrrole cofactor. Adenosylcobalamin belongs to the same class of compounds as heme, chlorophyll, siroheme, and coenzyme F430. Most prokaryotic organisms as well as animals (including human) and protists have enzyme that require adenosylcobalamin as cofactor, whereas plants and fungi are thought not to use it. It is one of the most structurally complex protein cofactors ans its biosynthesis remains one of the most enigmatic and exigent metabolic pathways in nature, requiring around 30 enzymes. Two distinct yet similar route exist, known as the oxygene-dependent (aerobic route) and oxygen-independent (anaerobic route) pathways. These pathways diverge at precorrin-2 and merge again at adenosylcobyrate. The major difference between these two routes include the timing of cobalt insertion, the requirement for oxygen and the nature of the extruded carbon fragment which is lost during the ring construction process [McGoldrick et al, 2005]. None - {{∅}} None - {{∅},{t}} Unexplained
UCR05812 H(+) + NADH + cobalt-precorrin-6A = NAD(+) + cobalt-precorrin-6B None - {{∅}} True - {{t}} Unconfirmed presence
UER00212 cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10~1 S-adenosyl-L-methionine + 1 precorrin-2 => 1 H(+) + 1 S-adenosyl-L-homocysteine + 1 precorrin-3A. None - {{∅}} None - {{∅}} Unexplained
UER00224 cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin-2 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 3. None - {{∅}} True - {{t}} Unconfirmed presence
UCR05223 GMP + adenosylcobalamin = adenosylcobinamide-GDP + alpha-ribazole None - {{∅}} True - {{t}} Unconfirmed presence