| UPA00647 | coenzyme M-coenzyme B heterodisulfide reduction~All processes in methanogenesis lead to the formation of a mixed disulfide bond between coenzyme M and coenzyme B, by a reaction in which coenzyme B reduces methyl-coenzyme M , leading to formation of methane and a coenzyme M-coenzyme B heterodisulfide [PMID:12102556] . There are two different systems that are capable of reducing the coenzyme M-coenzyme B heterodisulfide, using either H2 or a reduced coenzyme F420 as electron donors [PMID:15168610]. . | None - {{∅}} | None - {{∅}} | Unexplained |  |