| UER00466 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 L-glutamate => 1 2-oxoglutarate + 1 LL-2,6-diaminopimelate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00020 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3~1 L-2-succinylamino-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-succinyl-LL-2,6-diaminopimelate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00023 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3~1 (S)-2-acetamido-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-acetyl-LL-2,6-diaminopimelate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00018 |
(S)-tetrahydrodipicolinate from L-aspartate: step 4/4~(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + [NADH or NADPH] => (S)-tetrahydrodipicolinate + H(2)O + [NAD(+) or NADP(+)]. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UER00024 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3~1 H(2)O + 1 N-acetyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 acetate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00032 |
L-lysine from L-alpha-aminoadipate (fungal route): step 1/3~1 ATP + 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH => 1 AMP + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) + 1 diphosphate + 1 holo-Lys2. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-2-UER00018 |
|
True - {{t}} |
None - {{∅}} |
Missing |
|
| UPA00404 |
L-lysine biosynthesis~This pathway represents the biosynthesis of the basic amino-acid L-lysine. L-lysine biosynthesis is peculiar because it has two different anabolic routes that evolved separately in organisms, the diaminopimelate (DAP) and aminoadipate (AAA) pathways. The DAP pathway synthesizes L-lysine from aspartate and pyruvate, and diaminopimelate is an intermediate. The DAP pathway is utilised by most bacteria, some archaea, some fungi, some algae, and plants. The AAA pathway synthesizes L-lysine from 2-oxoglutarate (alpha-ketoglutarate) and acetyl coenzyme A (acetyl-CoA), and L-alpha-aminoadipate is an intermediate. The AAA pathway is utilised by most fungi, some algae, the bacterium Thermus thermophilus, and probably some archaea, such as Sulfolobus, Thermoproteus, and Pyrococcus [source: InterPro]. No organism is known to possess both pathways [PMID:20418392]. L-lysine is one of the 10 essential amino-acids that mammals are unable to synthesize, and must therefore acquire in their diets. |
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| UER00017 |
(S)-tetrahydrodipicolinate from L-aspartate: step 3/4~1 L-aspartate 4-semialdehyde + 1 pyruvate => 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(2)O. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UER01028 |
None~1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NAD(+). |
True - {{t}} |
None - {{∅}} |
Missing |
|
| ULS00013 |
L-lysine from L-alpha-aminoadipate (fungal route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| MUER12 |
Meta-UER 12~1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UER00031 |
L-alpha-aminoadipate from 2-oxoglutarate: step 5/5~1 2-oxoadipate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-alpha-aminoadipate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00036 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5~1 ATP + 1 [LysW]-L-2-aminoadipate => 1 ADP + 1 [LysW]-L-2-aminoadipyl 6-phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00038 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5~1 L-glutamate + 1 [LysW]-L-2-aminoadipate 6-semialdehyde => 1 2-oxoglutarate + 1 [LysW]-L-lysine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00027 |
L-lysine from DL-2,6-diaminopimelate: step 1/1~1 DL-2,6-diaminopimelate => 1 CO(2) + 1 L-lysine. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00039 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5~1 H(2)O + 1 [LysW]-L-lysine => 1 L-lysine + 1 [LysW]. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00022 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 acetyl-CoA => 1 (S)-2-acetamido-6-oxopimelate + 1 CoA. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00030 |
L-alpha-aminoadipate from 2-oxoglutarate: step 4/5~1 NAD(+) + 1 homoisocitrate => 1 2-oxoadipate + 1 CO(2) + 1 H(+) + 1 NADH. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00014 |
L-lysine from L-alpha-aminoadipate (Thermus route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00025 |
DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1~1 LL-2,6-diaminopimelate => 1 DL-2,6-diaminopimelate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| VariantPath-4-UPA00034 |
|
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| UER00026 |
DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1~1 (S)-tetrahydrodipicolinate + 1 H(+) + 1 H(2)O + 1 NADPH + 1 NH(3) => 1 DL-2,6-diaminopimelate + 1 NADP(+). |
True - {{t}} |
None - {{∅}} |
Missing |
|
| VariantPath-3-UPA00034 |
|
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| UER00037 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5~1 H(+) + 1 NADPH + 1 [LysW]-L-2-aminoadipyl 6-phosphate => 1 NADP(+) + 1 [LysW]-L-2-aminoadipate 6-semialdehyde + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UPA00033 |
L-lysine biosynthesis via AAA pathway~Biosynthesis of L-lysine through the alpha-amino adipic acid (AAA) pathway. It was first believed that this pathway was a specific character of fungi. In 1998, a gene cluster of a thermophilic bacterium (Thermus thermophilus) was shown to synthesize L-lysine through the AAA pathway. This pathway is present in hyperthermophilic archaea too (P. horikoshii and P. abyssi). Hence, this pathway is distributed among the three super-kingdoms as proposed by Woese and Fox in 1997 [PMID:270744]. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-1-UPA00034 |
|
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| ULS00009 |
DL-2,6-diaminopimelate from LL-2,6-diaminopimelate |
True - {{t}} |
None - {{∅}} |
Missing |
|
| VariantPath-2-UPA00034 |
|
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| UPA00034 |
L-lysine biosynthesis via DAP pathway~Biosynthesis of L-lysine through the diaminopimelate (DAP) pathway. <br> The L-lysine is synthesized from L-aspartate and pyruvate through diaminopimelate via four variants. <br> This pathway is utilised by most bacteria, some archaea, some fungi, some algae, and higher plants.<br> In bacteria, DAP is not only a direct precursor of lysine, but it is also an important constituent of the cell wall peptidoglycan. <br> The DAP pathway is of special interest for pharmacology, since the absence of DAP in mammalian cells allows for the use of the DAP biosynthetic genes as a bacteria-specific drug target. <br> Most bacteria use only one of the four variants, although certain bacteria, such as <i>C. glutamicum </i> and <i>Bacillus macerans</i>, possess both the succinylase and dehydrogenase pathways. |
True - {{t}} |
None - {{∅},{t}} |
Missing |
|
| UER00021 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3~1 H(2)O + 1 N-succinyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 succinate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00035 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5~1 ATP + 1 L-alpha-aminoadipate + 1 [LysW] => 1 ADP + 1 [LysW]-L-2-aminoadipate + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER01027 |
L-alpha-aminoadipate from 2-oxoglutarate: step 3/5~1 H(2)O + 1 homo-cis-aconitate => 1 homoisocitrate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00008 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00029 |
L-alpha-aminoadipate from 2-oxoglutarate: step 2/5~1 (R)-homocitrate => 1 H(2)O + 1 homo-cis-aconitate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00227 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route) |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00033 |
L-lysine from L-alpha-aminoadipate (fungal route): step 2/3~1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| MUER21 |
Meta-UER 21~1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UER00028 |
L-alpha-aminoadipate from 2-oxoglutarate: step 1/5~1 2-oxoglutarate + 1 H(2)O + 1 acetyl-CoA => 1 (R)-homocitrate + 1 CoA. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00011 |
L-lysine from DL-2,6-diaminopimelate |
True - {{t}} |
None - {{∅}} |
Missing |
|
| ULS00006 |
(S)-tetrahydrodipicolinate from L-aspartate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| VariantPath-1-UER00018 |
|
True - {{t}} |
None - {{∅}} |
Missing |
|
| ULS00012 |
L-alpha-aminoadipate from 2-oxoglutarate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-2-UPA00033 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-1-UPA00033 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00019 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 succinyl-CoA => 1 CoA + 1 L-2-succinylamino-6-oxopimelate. |
True - {{t}} |
None - {{∅}} |
Missing |
|
| ULS00010 |
DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER01029 |
None~1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADPH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NADP(+). |
True - {{t}} |
None - {{∅}} |
Missing |
|
| UER00034 |
L-lysine from L-alpha-aminoadipate (fungal route): step 3/3~1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADH. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00007 |
LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) |
True - {{t}} |
None - {{∅}} |
Missing |
|