UER00223 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10~1 Co(2+) + 1 sirohydrochlorin => 2 H(+) + 1 cobalt-precorrin-2. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05181 |
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05218 |
FMNH(2) + 2 cob(II)yrinate a,c-diamide = FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR03948 |
S-adenosyl-L-methionine + precorrin-2 = H(+) + S-adenosyl-L-homocysteine + precorrin-3A |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00216 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10~1 H(2)O + 1 S-adenosyl-L-methionine + 1 precorrin-5 => 1 S-adenosyl-L-homocysteine + 1 acetate + 1 precorrin-6A. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05223 |
GMP + adenosylcobalamin = adenosylcobinamide-GDP + alpha-ribazole |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00227 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 5B => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin-6A. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05810 |
S-adenosyl-L-methionine + cobalt-precorrin 4 = S-adenosyl-L-homocysteine + cobalt-precorrin 5A |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00212 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10~1 S-adenosyl-L-methionine + 1 precorrin-2 => 1 H(+) + 1 S-adenosyl-L-homocysteine + 1 precorrin-3A. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR03194 |
2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UPA00148 |
adenosylcobalamin biosynthesis~Biosynthesis of adenosylcobalamin (vitamin B12), a modified tetrapyrrole cofactor. Adenosylcobalamin belongs to the same class of compounds as heme, chlorophyll, siroheme, and coenzyme F430. Most prokaryotic organisms as well as animals (including human) and protists have enzyme that require adenosylcobalamin as cofactor, whereas plants and fungi are thought not to use it. It is one of the most structurally complex protein cofactors ans its biosynthesis remains one of the most enigmatic and exigent metabolic pathways in nature, requiring around 30 enzymes. Two distinct yet similar route exist, known as the oxygene-dependent (aerobic route) and oxygen-independent (anaerobic route) pathways. These pathways diverge at precorrin-2 and merge again at adenosylcobyrate. The major difference between these two routes include the timing of cobalt insertion, the requirement for oxygen and the nature of the extruded carbon fragment which is lost during the ring construction process [McGoldrick et al, 2005]. |
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR05220 |
ATP + cob(I)yrinic acid a,c-diamide = adenosylcob(III)yrinic acid a,c-diamide + triphosphate |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UCR05217 |
H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05180 |
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00237 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7~1 GTP + 1 adenosylcobinamide phosphate => 1 adenosylcobinamide-GDP + 1 diphosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00238 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7~1 adenosylcobinamide-GDP + 1 alpha-ribazole => 1 GMP + 1 adenosylcobalamin. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00232 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7~1 FMNH(2) + 2 cob(II)yrinate a,c-diamide => 1 FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05225 |
4 ATP + 4 H(2)O + 4 L-glutamine + adenosylcob(III)yrinic acid a,c-diamide = 4 ADP + 4 L-glutamate + adenosylcobyrinic acid a,c-diamide + 4 phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR06558 |
GTP + adenosylcobinamide = GDP + adenosylcobinamide phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00218 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10~2 S-adenosyl-L-methionine + 1 precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 precorrin-8X. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00092 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05221 |
ATP + adenosylcobinamide = ADP + adenosylcobinamide phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05808 |
S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-factor III |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00230 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10~1 cobalt-precorrin 8 => 1 cob(III)yrinic acid. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05149 |
2 S-adenosyl-L-methionine + precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + precorrin-8X |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00091 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00173 |
sirohydrochlorin from precorrin-2 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00221 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10~1 ATP + 1 Co(2+) + 1 H(2)O + 1 hydrogenobyrinic acid a,c-diamide => 1 ADP + 1 H(+) + 1 cob(II)yrinate a,c-diamide + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05226 |
(R)-1-aminopropan-2-ol + adenosylcobyrinic acid a,c-diamide = H(2)O + adenosylcobinamide |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00235 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7~1 (R)-1-aminopropan-2-ol + 1 adenosylcobyrinic acid a,c-diamide => 1 H(2)O + 1 adenosylcobinamide. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00090 |
precorrin-2 from uroporphyrinogen III |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05177 |
precorrin-8X = hydrogenobyrinic acid |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00561 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10~1 H(2)O + 1 cobalt-precorrin 5A => 1 acetaldehyde + 1 cobalt-precorrin 5B. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05815 |
2 ATP + 2 H(2)O + 2 L-glutamine + cob(III)yrinic acid = 2 ADP + 2 L-glutamate + cob(II)yrinate a,c-diamide + 2 phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00233 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7~1 ATP + 1 cob(I)yrinic acid a,c-diamide => 1 adenosylcob(III)yrinic acid a,c-diamide + 1 triphosphate. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UER00226 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 4 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 5A. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR07772 |
H(2)O + cobalt-precorrin 5A = acetaldehyde + cobalt-precorrin 5B |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05227 |
ATP + Co(2+) + H(2)O + hydrogenobyrinic acid a,c-diamide = ADP + H(+) + cob(II)yrinate a,c-diamide + phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05150 |
NADP(+) + precorrin-6B = H(+) + NADPH + precorrin-6A |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00219 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10~1 precorrin-8X => 1 hydrogenobyrinic acid. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00225 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin 3 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 4. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00214 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10~1 S-adenosyl-L-methionine + 1 precorrin-3B => 1 S-adenosyl-L-homocysteine + 1 precorrin-4. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00229 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10~2 S-adenosyl-L-methionine + 1 cobalt-precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 8. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00093 |
adenosylcobalamin from cob(II)yrinate a,c-diamide |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UCR07773 |
S-adenosyl-L-methionine + cobalt-precorrin 5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR03947 |
NAD(+) + precorrin-2 = H(+) + NADH + sirohydrochlorin |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00217 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10~1 H(+) + 1 NADPH + 1 precorrin-6A => 1 NADP(+) + 1 precorrin-6B. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-2-UER00236 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00236 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7~adenosylcobinamide + [ATP or GTP] => adenosylcobinamide phosphate + [ADP or GDP]. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00211 |
precorrin-2 from uroporphyrinogen III: step 1/1~2 S-adenosyl-L-methionine + 1 uroporphyrinogen III => 2 S-adenosyl-L-homocysteine + 1 precorrin-2. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00954 |
None~1 GTP + 1 adenosylcobinamide => 1 GDP + 1 adenosylcobinamide phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-1-UER00236 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05813 |
2 S-adenosyl-L-methionine + cobalt-precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + cobalt-precorrin 8 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00234 |
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7~4 ATP + 4 H(2)O + 4 L-glutamine + 1 adenosylcob(III)yrinic acid a,c-diamide => 4 ADP + 4 L-glutamate + 1 adenosylcobyrinic acid a,c-diamide + 4 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00222 |
sirohydrochlorin from precorrin-2: step 1/1~1 NAD(+) + 1 precorrin-2 => 1 H(+) + 1 NADH + 1 sirohydrochlorin. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05807 |
Co(2+) + sirohydrochlorin = 2 H(+) + cobalt-precorrin-2 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR08716 |
cobalt-factor III = cobalt-precorrin 3 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00215 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10~1 S-adenosyl-L-methionine + 1 precorrin-4 => 1 S-adenosyl-L-homocysteine + 1 precorrin-5. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00231 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10~2 ATP + 2 H(2)O + 2 L-glutamine + 1 cob(III)yrinic acid => 2 ADP + 2 L-glutamate + 1 cob(II)yrinate a,c-diamide + 2 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00953 |
None~1 ATP + 1 adenosylcobinamide => 1 ADP + 1 adenosylcobinamide phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-1-UPA00148 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR05814 |
cobalt-precorrin 8 = cob(III)yrinic acid |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-2-UPA00148 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR05222 |
GTP + adenosylcobinamide phosphate = adenosylcobinamide-GDP + diphosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05219 |
S-adenosyl-L-homocysteine + acetate + precorrin-6A = H(2)O + S-adenosyl-L-methionine + precorrin-5 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05809 |
S-adenosyl-L-methionine + cobalt-precorrin 3 = S-adenosyl-L-homocysteine + cobalt-precorrin 4 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00224 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10~1 S-adenosyl-L-methionine + 1 cobalt-precorrin-2 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 3. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05224 |
2 ATP + 2 H(2)O + 2 L-glutamine + hydrogenobyrinic acid = 2 ADP + 2 L-glutamate + hydrogenobyrinic acid a,c-diamide + 2 phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00213 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10~1 H(+) + 1 NADH + 1 O(2) + 1 precorrin-3A => 1 H(2)O + 1 NAD(+) + 1 precorrin-3B. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00228 |
cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10~1 H(+) + 1 NADH + 1 cobalt-precorrin-6A => 1 NAD(+) + 1 cobalt-precorrin-6B. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00220 |
cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10~2 ATP + 2 H(2)O + 2 L-glutamine + 1 hydrogenobyrinic acid => 2 ADP + 2 L-glutamate + 1 hydrogenobyrinic acid a,c-diamide + 2 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05812 |
H(+) + NADH + cobalt-precorrin-6A = NAD(+) + cobalt-precorrin-6B |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|