| UER00029 |
L-alpha-aminoadipate from 2-oxoglutarate: step 2/5~1 (R)-homocitrate => 1 H(2)O + 1 homo-cis-aconitate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00037 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5~1 H(+) + 1 NADPH + 1 [LysW]-L-2-aminoadipyl 6-phosphate => 1 NADP(+) + 1 [LysW]-L-2-aminoadipate 6-semialdehyde + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER01027 |
L-alpha-aminoadipate from 2-oxoglutarate: step 3/5~1 H(2)O + 1 homo-cis-aconitate => 1 homoisocitrate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR03098 |
ATP + L-alpha-aminoadipate = alpha-aminoadipoyl-C6-AMP + diphosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00013 |
L-lysine from L-alpha-aminoadipate (fungal route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00039 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5~1 H(2)O + 1 [LysW]-L-lysine => 1 L-lysine + 1 [LysW]. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00033 |
L-lysine from L-alpha-aminoadipate (fungal route): step 2/3~1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00034 |
L-lysine from L-alpha-aminoadipate (fungal route): step 3/3~1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADH. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR01939 |
2-oxoglutarate + L-alpha-aminoadipate = 2-oxoadipate + L-glutamate |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR00715 |
H(2)O + NAD(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADH |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00028 |
L-alpha-aminoadipate from 2-oxoglutarate: step 1/5~1 2-oxoglutarate + 1 H(2)O + 1 acetyl-CoA => 1 (R)-homocitrate + 1 CoA. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00035 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5~1 ATP + 1 L-alpha-aminoadipate + 1 [LysW] => 1 ADP + 1 [LysW]-L-2-aminoadipate + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-1-UPA00033 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
| UCR00271 |
2-oxoglutarate + H(2)O + acetyl-CoA = (R)-homocitrate + CoA |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR02315 |
H(2)O + NADP(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADPH |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00014 |
L-lysine from L-alpha-aminoadipate (Thermus route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR09777 |
H(+) + NADPH + [LysW]-L-2-aminoadipyl 6-phosphate = NADP(+) + [LysW]-L-2-aminoadipate 6-semialdehyde + phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-2-UPA00033 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
| UCR04863 |
alpha-aminoadipoyl-C6-AMP + holo-Lys2 = AMP + alpha-aminoadipoyl-S-acyl enzyme |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04862 |
NAD(+) + homoisocitrate = 2-oxaloglutaric acid + H(+) + NADH |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR09779 |
H(2)O + [LysW]-L-lysine = L-lysine + [LysW] |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00012 |
L-alpha-aminoadipate from 2-oxoglutarate |
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
| UER00030 |
L-alpha-aminoadipate from 2-oxoglutarate: step 4/5~1 NAD(+) + 1 homoisocitrate => 1 2-oxoadipate + 1 CO(2) + 1 H(+) + 1 NADH. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04371 |
homoisocitrate = H(2)O + homo-cis-aconitate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR01936 |
2-oxaloglutaric acid = 2-oxoadipate + CO(2) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00038 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5~1 L-glutamate + 1 [LysW]-L-2-aminoadipate 6-semialdehyde => 1 2-oxoglutarate + 1 [LysW]-L-lysine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UPA00033 |
L-lysine biosynthesis via AAA pathway~Biosynthesis of L-lysine through the alpha-amino adipic acid (AAA) pathway. It was first believed that this pathway was a specific character of fungi. In 1998, a gene cluster of a thermophilic bacterium (Thermus thermophilus) was shown to synthesize L-lysine through the AAA pathway. This pathway is present in hyperthermophilic archaea too (P. horikoshii and P. abyssi). Hence, this pathway is distributed among the three super-kingdoms as proposed by Woese and Fox in 1997 [PMID:270744]. |
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
| UER00032 |
L-lysine from L-alpha-aminoadipate (fungal route): step 1/3~1 ATP + 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH => 1 AMP + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) + 1 diphosphate + 1 holo-Lys2. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00036 |
L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5~1 ATP + 1 [LysW]-L-2-aminoadipate => 1 ADP + 1 [LysW]-L-2-aminoadipyl 6-phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR09776 |
ATP + [LysW]-L-2-aminoadipate = ADP + [LysW]-L-2-aminoadipyl 6-phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR03444 |
(R)-homocitrate = H(2)O + homo-cis-aconitate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04390 |
H(+) + NADPH + alpha-aminoadipoyl-S-acyl enzyme = L-2-aminoadipate 6-semialdahyde + NADP(+) + holo-Lys2 |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR09775 |
ATP + L-alpha-aminoadipate + [LysW] = ADP + [LysW]-L-2-aminoadipate + phosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR09778 |
L-glutamate + [LysW]-L-2-aminoadipate 6-semialdehyde = 2-oxoglutarate + [LysW]-L-lysine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00031 |
L-alpha-aminoadipate from 2-oxoglutarate: step 5/5~1 2-oxoadipate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-alpha-aminoadipate. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|