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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
Evidence_84522 TIGR03695 HMM None - {{∅}} None - {{∅}} Unexplained
Component_62872 prenyltransferase None - {{∅}} True - {{t}} Unconfirmed presence
Component_123 isochorismate synthase None - {{∅}} None - {{∅}} Unexplained
Component_121 SEPHCHC synthase None - {{∅}} None - {{∅}} Unexplained
Evidence_84462 TIGR01475 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_70 TIGR00751 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_84534 TIGR03699 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_2494 TIGR01923 HMM None - {{∅}} None - {{∅}} Unexplained
GenProp0058 menaquinone biosynthesis via SEPHCHC~Menaquinone (also known as Vitamin K2) is one of the quinone cofactors which play an essential role in hydrogen transfer reactions, particularly during anaerobic respiration. Menaquinone in E. coli and various other bacteria is synthesized from chorismate, 2-oxoglutarate, polyprenyl-pyrophosphate and S-adenosylmethionine. A very similar molecule (phylloquinone, vitamin K1) is found in cyanobacteria and plants which contains a shorter isoprenoid (phytyl) chain which in which three of the four double bonds are reduced. In animals, both vitamins K1 and K2 act as cofactors for gamma-carboxylation of glutamate (Glu -> Gla) which is critical for coagulation factors. Note that an alternative pathway to menaquinone biosynthesis operates in Helicobacter pylori, Campylobacter jejuni, Streptomyces, and other species (see PMID:18801996). That pathway is not described here. None - {{∅}} None - {{∅}} Unexplained
Component_126 demethylmenaquinone methyltransferase None - {{∅}} True - {{t}} Unconfirmed presence
Component_125 o-succinylbenzoate--CoA ligase None - {{∅}} None - {{∅}} Unexplained
Evidence_84458 PF02621 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_2564 TIGR01928 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_2614 TIGR01934 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_122 naphthoate synthase None - {{∅}} None - {{∅}} Unexplained
Evidence_55 TIGR00173 HMM None - {{∅}} None - {{∅}} Unexplained
Component_62866 futalosine hydrolase None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0829 menaquinone biosynthesis via futalosine~This pathway for the biosynthesis of menaquinone begins with chorismate, but otherwise is completely distinctive compared to the well-known E. coli pathway (GenProp0058). None - {{∅}} None - {{∅},{t}} Unexplained
Component_62867 de-hypoxanthine futalosine (DHFL) cyclase None - {{∅}} True - {{t}} Unconfirmed presence
Component_62868 1,4-dihydroxy-6-naphthoate (DHN) synthase None - {{∅}} None - {{∅}} Unexplained
Component_62929 SHCHC synthase None - {{∅}} None - {{∅}} Unexplained
Component_62865 futalosine synthase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_60 TIGR00543 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_84464 TIGR03701 HMM None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0836 menaquinone biosynthesis~Menaquinone may be synthesized by one of two independent pathways. The better known pathway, which includes MenA, MenB, etc., as found in Escherichia coli, passes through the intermediate SEPHCHC (see GenProp0058). An alternate pathway, found in both Helicobacter pylori and Streptomyces coelicolor, involves the intermediate futalosine (see GenProp0829). This property evaluates to YES is either menaquinone biosynthesis pathway is complete. None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_84535 TIGR03700 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_84459 PF02642 HMM None - {{∅}} None - {{∅}} Unexplained
Component_128 1,4-dihydroxy-2-naphthoate prenyl-transferase None - {{∅}} None - {{∅}} Unexplained
Evidence_84467 TIGR03664 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_2554 TIGR01927 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_2574 TIGR01929 HMM None - {{∅}} None - {{∅}} Unexplained
Component_62873 decarboxylase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_84523 GenProp0058 GENPROP None - {{∅}} None - {{∅}} Unexplained
Component_124 o-succinylbenzoate synthase None - {{∅}} None - {{∅}} Unexplained
Component_62930 menaquinone biosynthesis: SEPHCHC or futalosine None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_84524 GenProp0829 GENPROP None - {{∅}} None - {{∅},{t}} Unexplained
Component_62938 putative menaquinone biosynthesis protein, SCO4494 family None - {{∅}} True - {{t}} Unconfirmed presence