| UPA00002 |
2-deoxy-D-ribose 1-phosphate degradation~This pathway provides a direct metabolic link between the deoxyribose moiety of nucleosides and central carbon metabolism, independent of the pentose phosphate cycle. Two enzymes provide this link: the phosphopentomutases (PPMs) and 2-deoxyribose 5-phosphate aldolases (DERAs). PPM isomerizes deoxyribose 1-phosphate to deoxyribose 5-phosphate. Subsequently, DERA cleaves the pentose phosphate to acetaldehyde and glyceraldehyde 3-phosphate, allowing further metabolism to obtain carbon and energy. The deoxyribose 1-phosphate is supplied by various nucleoside phosphorylases, such as thymidine phosphorylase, uridine phosphorylase and purine nucleoside phosphorylase, which release the pentose moiety from (deoxy)ribonucleosides, producing (deoxy)ribose 1-phosphate. . |
None - {{∅}} |
None - {{∅}} |
Unexplained |
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