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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
ULS00026 O-acetyl-L-homoserine from L-homoserine True - {{t}} None - {{∅}} Missing
ULS00214 L-homocysteine from O-succinyl-L-homoserine True - {{t}} None - {{∅}} Missing
MUER16 Meta-UER 16~H(+) + L-aspartate 4-semialdehyde + [NADH or NADPH] => L-homoserine + [NAD(+) or NADP(+)]. True - {{t}} True - {{t}} Confirmed presence
UPA00051 L-methionine biosynthesis via de novo pathway~Sulfur-containing amino-acid L-methionine (2-amino-4-(methylthio)butanoic acid) is synthesized de novo by most microorganisms and plants after the initial steps of inorganic sulfate assimilation and synthesis of cysteine or homocysteine. There are two alternative pathways of methionine synthesis in microorganisms. The enterobacterial type trans-sulfuration pathway involves cystathionine as an intermediate and utilizes cysteine as the sulfur source. In contrast, the direct sulfhydrylation pathway found in yeast (Saccharomyces cerevisiae), spirochete (Leptospira meyeri) and actinomycetes (Corynebacterium glutamicum) bypasses cystathionine and uses inorganic sulfur instead. Although yeast, fungi and higher plants have both transsulfuration and direct sulfhydrylation pathways, only the bacteria C. glutamicum, B. subtilis, P. aeruginosa, P. putida and L. meyeri have been shown to have both pathways. Methionine biosynthesis is a central pathway, as it controls a large number of cellular processes such as translation of mRNA into proteins (not only as a substrate for protein elongation but also as the initiator of protein synthesis) and transmethylation reactions via the formation of S-adenosylmethionine (SAM) (cf activated methyl cycle pathway). True - {{t}} None - {{∅},{t}} Missing
ULS00025 L-homoserine from L-aspartate True - {{t}} True - {{t}} Confirmed presence
ULS00029 L-cystathionine from O-succinyl-L-homoserine True - {{t}} None - {{∅}} Missing
ULS00213 L-cystathionine from O-acetyl-L-homoserine True - {{t}} None - {{∅}} Missing
MUER12 Meta-UER 12~1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP. True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-9-UPA00051 True - {{t}} None - {{∅},{t}} Missing
UER00449 L-homocysteine from O-succinyl-L-homoserine: step 1/1~1 O-succinyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 succinate. True - {{t}} None - {{∅}} Missing
ULS00030 L-homocysteine from L-cystathionine True - {{t}} True - {{t}} Confirmed presence
VariantPath-6-UPA00051 True - {{t}} None - {{∅},{t}} Missing
ULS00035 L-methionine from L-homocysteine (BhmT route) True - {{t}} None - {{∅}} Missing
VariantPath-7-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-8-UPA00051 True - {{t}} None - {{∅},{t}} Missing
ULS00031 L-homocysteine from O-acetyl-L-homoserine True - {{t}} None - {{∅}} Missing
MUER7 Meta-UER 7~1 L-homocysteine + 1 betaine => 1 L-methionine + 1 N,N-dimethylglycine. True - {{∅},{t}} None - {{∅}} Missing
VariantPath-2-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-11-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-10-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-1-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-3-UPA00051 True - {{t}} None - {{∅},{t}} Missing
UER00950 None~1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADPH => 1 L-homoserine + 1 NADP(+). True - {{t}} None - {{∅}} Missing
VariantPath-12-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-5-UPA00051 True - {{t}} None - {{∅},{t}} Missing
VariantPath-4-UPA00051 True - {{t}} None - {{∅},{t}} Missing
UER00949 None~1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADH => 1 L-homoserine + 1 NAD(+). True - {{t}} None - {{∅}} Missing
ULS00027 O-succinyl-L-homoserine from L-homoserine True - {{t}} True - {{t}} Confirmed presence
UER00079 L-homocysteine from O-acetyl-L-homoserine: step 1/1~1 O-acetyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 acetate. True - {{t}} None - {{∅}} Missing
ULS00033 L-methionine from L-homocysteine (MetH route) True - {{t}} None - {{∅}} Missing
UER00075 O-succinyl-L-homoserine from L-homoserine: step 1/1~1 L-homoserine + 1 succinyl-CoA => 1 CoA + 1 O-succinyl-L-homoserine. True - {{t}} True - {{t}} Confirmed presence
UER00078 L-homocysteine from L-cystathionine: step 1/1~1 H(2)O + 1 L-cystathionine => 1 L-homocysteine + 1 NH(3) + 1 pyruvate. True - {{t}} True - {{t}} Confirmed presence
UER00082 L-methionine from L-homocysteine (MetE route): step 1/1~1 5-methyltetrahydropteroyltri-L-glutamate + 1 L-homocysteine => 1 L-methionine + 1 tetrahydropteroyltri-L-glutamate. True - {{t}} True - {{t}} Confirmed presence
UER00081 L-methionine from L-homocysteine (MetH route): step 1/1~1 5-methyl-THF + 1 L-homocysteine => 1 5,6,7,8-tetrahydrofolate + 1 L-methionine. True - {{t}} None - {{∅}} Missing
VariantPath-1-MUER16 True - {{t}} None - {{∅}} Missing
MUER21 Meta-UER 21~1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate. True - {{∅},{t}} True - {{t}} Confirmed presence
UER00074 O-acetyl-L-homoserine from L-homoserine: step 1/1~1 L-homoserine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-homoserine. True - {{t}} None - {{∅}} Missing
UER00077 L-cystathionine from O-succinyl-L-homoserine: step 1/1~1 L-cysteine + 1 O-succinyl-L-homoserine => 1 L-cystathionine + 1 succinate. True - {{t}} None - {{∅}} Missing
ULS00034 L-methionine from L-homocysteine (MetE route) True - {{t}} True - {{t}} Confirmed presence
VariantPath-2-MUER16 True - {{t}} None - {{∅}} Missing
UER00448 L-cystathionine from O-acetyl-L-homoserine: step 1/1~1 L-cysteine + 1 O-acetyl-L-homoserine => 1 L-cystathionine + 1 acetate. True - {{t}} None - {{∅}} Missing