| UPA00359 |
lipid IV(A) biosynthesis~Biosynthesis of lipid IV(A), the endotoxically inactive LPS lipid A precursor. Lipid A is one of the three components of lipopolysaccharide (LPS). It contains unusual fatty acids (e.g. hydroxy-myristic acid) and is inserted into the outer membrane while the rest of the LPS projects from the surface. Lipid A, the potent macrophage-activating component primarily responsible for LPS endotoxin activity, is a phosphorylated glucosamine disaccharide carrying long-chain saturated fatty acid (FA) substituents that anchor LPS in the outer membrane. Lipid A is similar for all Gram-negative Enterobacteriaceae, and synthetic lipid A produces effects identical to that isolated from Escherichia coli in both in vitro and in vivo endotoxin tests. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04606 |
UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + lipid X = 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + UDP |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00480 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6~1 H(2)O + 1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine => 1 UMP + 1 lipid X. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04550 |
UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + acyl-carrier protein = (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00229 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04657 |
2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + ATP = ADP + lipid IV(A) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00481 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6~1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + 1 lipid X => 1 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + 1 UDP. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-1-ULS00229 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-2-ULS00229 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00479 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6~1 (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + 1 UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine => 1 UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + 1 acyl-carrier protein. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00477 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6~1 (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + 1 UDP-N-acetyl-alpha-D-glucosamine => 1 UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + 1 acyl-carrier protein. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04567 |
(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + acyl-carrier protein |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04549 |
H(2)O + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = UMP + lipid X |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR04587 |
H(2)O + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + acetate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00482 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6~1 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + 1 ATP => 1 ADP + 1 lipid IV(A). |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00478 |
lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6~1 H(2)O + 1 UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine => 1 UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + 1 acetate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|